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202. P1‐602: DUTCH ONLINE REGISTRY FOR RECRUITMENT OF PARTICIPANTS FOR DEMENTIA STUDIES: HERSENONDERZOEK.NL AND BRAIN HEALTH REGISTRY

Author

Zwan, Marissa D., primary, Flenniken, Derek, additional, Finley, Shannon, additional, Ulbricht, Aaron, additional, Nosheny, Rachel, additional, Van der Flier, Wiesje M., additional, Sikkes, Sietske A.M., additional, Scheltens, Philip, additional, Truran-Sacrey, Diana, additional, Weiner, Michael, additional, and Prins, Niels D., additional

Published
2018
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205. P3‐289: HARMONIZATION OF SCD OPERATIONALIZATION ACROSS DIFFERENT MEMORY CLINIC SETTINGS: THE EURO‐SCD STUDY

Author

Jessen, Frank, primary, Wolfsgruber, Steffen, additional, Daamen, Marcel, additional, Molinuevo, José Luis, additional, Teunissen, Charlotte E., additional, Rami, Lorena, additional, Coll-Padros, Nina, additional, Bouwman, Femke H., additional, Slot, Rosalinde E.R., additional, Sikkes, Sietske A.M., additional, Wesselman, Linda M.P., additional, Peters, Oliver, additional, Buerger, Katharina, additional, Priller, Josef, additional, Laske, Christoph, additional, Teipel, Stefan J., additional, Spottke, Annika, additional, Heneka, Michael T., additional, Düzel, Emrah, additional, Drzezga, Alexander, additional, Boecker, Henning, additional, Van der Flier, Wiesje M., additional, and Wagner, Michael, additional

Published
2018
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206. The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description

Author

Holstege, Henne, primary, Beker, Nina, additional, Dijkstra, Tjitske, additional, Pieterse, Karlijn, additional, Wemmenhove, Elizabeth, additional, Schouten, Kimja, additional, Thiessens, Linette, additional, Horsten, Debbie, additional, Rechtuijt, Sterre, additional, Sikkes, Sietske, additional, van Poppel, Frans W.A., additional, Meijers-Heijboer, Hanne, additional, Hulsman, Marc, additional, and Scheltens, Philip, additional

Published
2018
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207. Computer‐assisted prediction of clinical progression in the earliest stages of AD

Author

Rhodius‐Meester, Hanneke F.M., primary, Liedes, Hilkka, additional, Koikkalainen, Juha, additional, Wolfsgruber, Steffen, additional, Coll‐Padros, Nina, additional, Kornhuber, Johannes, additional, Peters, Oliver, additional, Jessen, Frank, additional, Kleineidam, Luca, additional, Molinuevo, José Luis, additional, Rami, Lorena, additional, Teunissen, Charlotte E., additional, Barkhof, Frederik, additional, Sikkes, Sietske A.M., additional, Wesselman, Linda M.P., additional, Slot, Rosalinde E.R., additional, Verfaillie, Sander C.J., additional, Scheltens, Philip, additional, Tijms, Betty M., additional, Lötjönen, Jyrki, additional, and van der Flier, Wiesje M., additional

Published
2018
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208. Measuring cognition and function in the preclinical stage of Alzheimer's disease

Author

Weintraub, Sandra, primary, Carrillo, Maria C., additional, Farias, Sarah Tomaszewski, additional, Goldberg, Terry E., additional, Hendrix, James A., additional, Jaeger, Judith, additional, Knopman, David S., additional, Langbaum, Jessica B., additional, Park, Denise C., additional, Ropacki, Michael T., additional, Sikkes, Sietske A.M., additional, Welsh‐Bohmer, Kathleen A., additional, Bain, Lisa J., additional, Brashear, Robert, additional, Budur, Kumar, additional, Graf, Ana, additional, Martenyi, Ferenc, additional, Storck, Marta Segardahl, additional, and Randolph, Christopher, additional

Published
2018
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209. The Diagnostic Challenge of the Late-Onset Frontal Lobe Syndrome

Author

Vijverberg, Everard G. B., primary, Gossink, Flora, additional, Krudop, Welmoed, additional, Sikkes, Sietske, additional, Kerssens, Cora, additional, Prins, Niels, additional, Stek, Max, additional, Scheltens, Philip, additional, Pijnenburg, Yolande, additional, and Dols, Annemiek, additional

Published
2017
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211. The Pitfall of Behavioral Variant Frontotemporal Dementia Mimics Despite Multidisciplinary Application of the FTDC Criteria

Author

Krudop, Welmoed A., primary, Dols, Annemieke, additional, Kerssens, Cora J., additional, Eikelenboom, Piet, additional, Prins, Niels D., additional, Möller, Christiane, additional, Schouws, Sigfried, additional, Rhebergen, Didi, additional, van Exel, Eric, additional, van der Flier, Wiesje M., additional, Sikkes, Sietske, additional, Scheltens, Philip, additional, Stek, Max L., additional, and Pijnenburg, Yolande A.L., additional

Published
2017
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213. [P2-473]: THE EFFECTS OF AMYLOID ON SEMANTIC COMPLEXITY IN SPONTANEOUS SPEECH IN SUBJECTIVE COGNITIVE DECLINE

Author

Verfaillie, Sander C.J., primary, Witteman, Jurriaan, additional, Slot, Rosalinde E.R., additional, Pruis, Ilanah J., additional, Vermaat, Lieke E.W., additional, Mulder, Jacqueline, additional, Schiller, Niels O., additional, Scheltens, Philip, additional, van Berckel, Bart N.M., additional, van der Flier, Wiesje M., additional, and Sikkes, Sietske A.M., additional

Published
2017
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215. PROGNOSIS OF CLINICAL PROGRESSION IN SUBJECTIVE COGNITIVE DECLINE USING A CLINICAL DECISION SUPPORT SYSTEM

Author

Rhodius-Meester, Hanneke F.M., primary, Liedes, Hilkka, additional, Wolfsgruber, Steffen, additional, Coll-Padros, Nina, additional, Koikkalainen, Juha, additional, Kornhuber, Johannes, additional, Peters, Oliver, additional, Jessen, Frank, additional, Kleineidam, Luca, additional, Molinuevo, José Luis, additional, Rami, Lorena, additional, Teunissen, Charlotte E., additional, Barkhof, Frederik, additional, Sikkes, Sietske A.M., additional, Wesselman, Linda M.P., additional, Slot, Rosalinde E.R., additional, Scheltens, Philip, additional, Tijms, Betty M., additional, Lotjonen, Jyrki, additional, and van der Flier, Wiesje M., additional

Published
2017
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217. CHARACTERIZING INDIVIDUALS WITH SUBJECTIVE COGNITIVE DECLINE: THE SUBJECTIVE COGNITIVE IMPAIRMENT COHORT (SCIENCE)

Author

Slot, Rosalinde E.R., primary, Verfaillie, Sander C.J., additional, Overbeek, Jose M., additional, Timmers, Tessa, additional, Wesselman, Linda M.P., additional, Bouwman, Femke H., additional, Prins, Niels D., additional, Teunissen, Charlotte E., additional, Dols, Annemieke, additional, Barkhof, Frederik, additional, van Berckel, Bart N.M., additional, Scheltens, Philip, additional, Sikkes, Sietske A.M., additional, and van der Flier, Wiesje M., additional

Published
2017
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220. [P2-446]: ASSESSING EVERYDAY ACTIVITIES WITH THE SPANISH VERSION OF THE AMSTERDAM IADL QUESTIONNAIRE: GROUP DIFFERENCES AND RELATION WITH COGNITIVE AND PSYCHOSOCIAL MEASURES

Author

Facal, David, primary, Juncos-Rabadán, Onésimo, additional, Pereiro, Arturo X., additional, Ruiz-Carabias, Miguel Angel, additional, Campos-Magdaleno, Maria, additional, Lojo-Seoane, Cristina, additional, Mallo, Sabela C., additional, Santamaría, Pedro, additional, Jutten, Roos J., additional, and Sikkes, Sietske A.M., additional

Published
2017
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222. [P3-566]: IMPROVING BRAIN HEALTH THROUGH AN ONLINE LIFESTYLE PROGRAM: PREFERENCES OF INDIVIDUALS WITH SUBJECTIVE COGNITIVE DECLINE

Author

Wesselman, Linda M.P., primary, Schild, Ann-Katrin, additional, Coll-Padros, Nina, additional, van der Borg, Wieke, additional, Slot, Rosalinde E.R., additional, Sannemann, Lena, additional, Rami, Lorena, additional, Molinuevo, José Luis, additional, Bouwman, Femke H., additional, Jessen, Frank, additional, van der Flier, Wiesje M., additional, and Sikkes, Sietske A.M., additional

Published
2017
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224. IMPROVING BRAIN HEALTH THROUGH AN ONLINE LIFESTYLE PROGRAM: PREFERENCES OF INDIVIDUALS WITH SUBJECTIVE COGNITIVE DECLINE

Author

Wesselman, Linda M.P., primary, Schild, Ann-Katrin, additional, Coll-Padros, Nina, additional, van der Borg, Wieke, additional, Slot, Rosalinde E.R., additional, Sannemann, Lena, additional, Rami, Lorena, additional, Molinuevo, José Luis, additional, Bouwman, Femke H., additional, Jessen, Frank, additional, van der Flier, Wiesje M., additional, and Sikkes, Sietske A.M., additional

Published
2017
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225. [P4-302]: DOES BRAIN AMYLOID DEPOSITION IMPACT EVERYDAY FUNCTIONING IN SUBJECTS WITH COGNITIVE COMPLAINTS? RESULTS FROM THE INSIGHT COHORT

Author

Sikkes, Sietske A.M., primary, Gehrels, Anne, additional, Tijms, Betty M., additional, Habert, Marie-Odile, additional, Hampel, Harald, additional, Epelbaum, Stéphane, additional, Tandetnik, Caroline, additional, Bakardjian, Hovagim, additional, Scheltens, Philip, additional, and Dubois, Bruno, additional

Published
2017
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226. The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group

Author

Costa, Alberto, primary, Bak, Thomas, additional, Caffarra, Paolo, additional, Caltagirone, Carlo, additional, Ceccaldi, Mathieu, additional, Collette, Fabienne, additional, Crutch, Sebastian, additional, Della Sala, Sergio, additional, Démonet, Jean François, additional, Dubois, Bruno, additional, Duzel, Emrah, additional, Nestor, Peter, additional, Papageorgiou, Sokratis G., additional, Salmon, Eric, additional, Sikkes, Sietske, additional, Tiraboschi, Pietro, additional, van der Flier, Wiesje M., additional, Visser, Pieter Jelle, additional, and Cappa, Stefano F., additional

Published
2017
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227. Evaluation of the content coverage of questionnaires containing basic and instrumental activities of daily living (ADL) used in adult patients with brain tumors.

Author

Oort, Quirien, Taphoorn, Martin J. B., Sikkes, Sietske A. M., Uitdehaag, Bernard M. J., Reijneveld, Jaap C., and Dirven, Linda

Abstract

Background: Everyday functioning can be assessed using measures of basic activities of daily living (BADL) or instrumental activities of daily living (IADL). The aim of this review was to provide an overview of the scope and specific content of BADL and/or IADL covered by currently used questionnaires in adult brain tumor patient studies. Methods: Electronic databases were searched up to April 2017 to identify all eligible questionnaires with items regarding BADL/IADL in studies with adult brain tumor patients. Articles were selected using predetermined in- and exclusion criteria. Items with similar content were clustered into domains based on type of activity. Results: Thirty-one unique questionnaires containing at least one BADL and/or IADL item were identified; 21 and 29 questionnaires containing ≥ 1 BADL or IADL item, respectively. The percentage of ADL items in these questionnaires ranged from 4 to 100%. Only two questionnaires were specifically developed to measure BADL (Barthel Index and Katz-ADL) and two specifically for IADL (Lawton-Brody IADL and preliminary IADL-BN). Content clustering revealed that IADL had a larger variation in content (31 domains, e.g. work or leisure time activities) compared to BADL (15 domains, e.g. mobility or bathing/washing). Conclusion: Thirty-one questionnaires previously used in brain tumor studies contained items on BADL and/or IADL and covered a wide range of content, in particular for IADL. It is currently unclear which BADL/IADL are most relevant for brain tumor patients, and this should therefore be evaluated. Next, existing questionnaires could be adapted or validated, or new measures can be developed to meet these needs. [ABSTRACT FROM AUTHOR]

Published
2019
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228. Neuropsychological Test Performance of Cognitively Healthy Centenarians: Normative Data From the Dutch 100‐Plus Study.

Author

Beker, Nina, Sikkes, Sietske A.M., Hulsman, Marc, Schmand, Ben, Scheltens, Philip, and Holstege, Henne

Subjects
*NEUROPSYCHOLOGICAL tests, *ATTENTION, *CENTENARIANS, *COGNITION, *FATIGUE (Physiology), *INTELLECT, *MEMORY, *SENSORY disorders
Abstract

Objectives: The fraction of the population that reaches the age of 100 years is growing. At this age, dementia incidence is high and cognitive functioning is highly variable across individuals. Normative data for neuropsychological tests are lacking in centenarians, which hampers the ability to evaluate their cognitive functioning for both research and clinical practice. Here, we generated norms for neuropsychological tests in a sample of cognitively healthy centenarians while taking sensory impairments into account. Design: Cross‐sectional cohort study. Setting: Centenarians who participate in the prospective 100‐plus Study. Participants: A total of 235 centenarians (71.5% female), who self‐reported to be cognitively healthy, which was confirmed by an informant and a trained researcher. Measurements: We generated normative data for 15 cognitive tests, measuring global cognition (Mini‐Mental State Examination [MMSE]), premorbid intelligence, attention, language, memory, executive function, and visuospatial function by multiple linear regressions and/or by reporting percentiles. Results: Normative data for global cognition resulted in a mean MMSE score of 25.6 ± 3.1 (range = 17‐30; interquartile range = 24‐28). Vision problems and fatigue often complicated the ability to complete tests, and these problems explained 41% and 22% of the missing test scores, respectively. In contrast, hearing problems (4%) and task incomprehension (6%) rarely complicated test performance. While educational level was associated with performance on the majority of the tests, sex and age were only weakly associated with test performance. Conclusions: We generated normative data for 15 common neuropsychological tests in a large sample of cognitively healthy centenarians, while taking age‐related sensory impairments into consideration. These normative data allow the detection of deficits across a wide range of cognitive domains. Our results suggest that, next to education level, vision ability and the level of fatigue should be taken into account when evaluating cognitive functioning in centenarians. J Am Geriatr Soc 67:759–767, 2019. [ABSTRACT FROM AUTHOR]

Published
2019
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229. Implementation of subjective cognitive decline criteria in research studies

Author

Molinuevo, Jose L., Rabin, Laura A., Amariglio, Rebecca, Buckley, Rachel, Dubois, Bruno, Ellis, Kathryn A., Ewers, Michael, Hampel, Harald, Kloeppel, Stefan, Rami, Lorena, Reisberg, Barry, Saykin, Andrew J., Sikkes, Sietske, Smart, Colette M., Snitz, Beth E., Sperling, Reisa, van der Flier, Wiesje M., Wagner, Michael, Jessen, Frank, Molinuevo, Jose L., Rabin, Laura A., Amariglio, Rebecca, Buckley, Rachel, Dubois, Bruno, Ellis, Kathryn A., Ewers, Michael, Hampel, Harald, Kloeppel, Stefan, Rami, Lorena, Reisberg, Barry, Saykin, Andrew J., Sikkes, Sietske, Smart, Colette M., Snitz, Beth E., Sperling, Reisa, van der Flier, Wiesje M., Wagner, Michael, and Jessen, Frank

Abstract

Introduction: Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods: Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results: Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion: Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are propcised, to enhance comparability and generalizability across studies. (C) 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Published
2017

230. Non-Pharmacologic Interventions for Older Adults with Subjective Cognitive Decline: Systematic Review, Meta-Analysis, and Preliminary Recommendations

Author

Smart, Colette M., Karr, Justin E., Areshenkoff, Corson N., Rabin, Laura A., Hudon, Carol, Gates, Nicola, Ali, Jordan I., Arenaza-Urquijo, Eider M., Buckley, Rachel F., Chetelat, Gael, Hampel, Harald, Jessen, Frank, Marchant, Natalie L., Sikkes, Sietske A. M., Tales, Andrea, van der Flier, Wiesje M., Wesselman, Linda, Smart, Colette M., Karr, Justin E., Areshenkoff, Corson N., Rabin, Laura A., Hudon, Carol, Gates, Nicola, Ali, Jordan I., Arenaza-Urquijo, Eider M., Buckley, Rachel F., Chetelat, Gael, Hampel, Harald, Jessen, Frank, Marchant, Natalie L., Sikkes, Sietske A. M., Tales, Andrea, van der Flier, Wiesje M., and Wesselman, Linda

Abstract

In subjective cognitive decline (SCD), older adults present with concerns about self-perceived cognitive decline but are found to have clinically normal function. However, a significant proportion of those adults are subsequently found to develop mild cognitive impairment, Alzheimer's dementia or other neurocognitive disorder. In other cases, SCD may be associated with mood, personality, and physical health concerns. Regardless of etiology, adults with SCD may benefit from interventions that could enhance current function or slow incipient cognitive decline. The objective of this systematic review and meta-analysis, conducted in accordance with the PRISMA guidelines, is to examine the benefits of non-pharmacologic intervention (NPI) in persons with SCD. Inclusion criteria were studies of adults aged 55 + with SCD defined using published criteria, receiving NPI or any control condition, with cognitive, behavioural, or psychological outcomes in controlled trails. Published empirical studies were obtained through a standardized search of CINAHL Complete, Cochrane Central Register of Controlled Trials, MEDLINE with Full Text, PsycINFO, and PsycARTICLES, supplemented by a manual retrieval of relevant articles. Study quality and bias was determined using PEDro. Nine studies were included in the review and meta-analysis. A wide range of study quality was observed. Overall, a small effect size was found on cognitive outcomes, greater for cognitive versus other intervention types. The available evidence suggests that NPI may benefit current cognitive function in persons with SCD. Recommendations are provided to improve future trials of NPI in SCD.

Published
2017

234. FREQUENCY OF SUBJECTIVE COGNITIVE DECLINE CRITERIA IN STAGE 2 OF THE NEW NIA-AA FRAMEWORK: A MULTI-COHORT STUDY FROM THE SUBJECTIVE COGNITIVE DECLINE PROFESSIONAL INTEREST AREA

Author

Buckley, Rachel F., Sikkes, Sietske A.M., Wolfsgruber, Steffen, Ebenau, Jarith, Sánchez-Benavides, Gonzalo, Rami, Lorena, Rentz, Dorene M., Gifford, Katherine A., Wagner, Michael, Sperling, Reisa A., Molinuevo, Jose Luis, Jessen, Frank, van der Flier, Wiesje M., and Amariglio, Rebecca

Published
2019
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235. ATN BIOMARKER MODEL AS A DETERMINANT OF COGNITIVE DECLINE AND INCIDENT CLINICAL PROGRESSION IN SUBJECTIVE COGNITIVE DECLINE: THE SCIENCE PROJECT

Author

Ebenau, Jarith, Timmers, Tessa, Wesselman, Linda M.P., Verberk, Inge M.W., Verfaillie, Sander C.J., Slot, Rosalinde E.R., Teunissen, Charlotte E., Barkhof, Frederik, van den Bosch, Karlijn, van Leeuwenstijn, Mardou, Prins, Niels D., Sikkes, Sietske A.M., Scheltens, Philip, Van Berckel, Bart N.M., and van der Flier, Wiesje M.

Published
2019
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250. P4-153: Subjective Cognitive Decline and Progression to Dementia Due to AD and Non-AD in Memory Clinic and Community-Based Cohorts

Author

Slot, Rosalinde E.R., primary, Sikkes, Sietske A.M., additional, Verfaillie, Sander C.J., additional, Wolfsgruber, Steffen, additional, Brodaty, Henry, additional, Buckley, Rachel F., additional, Hampel, Harald, additional, Kochan, Nicole A., additional, Luck, Tobias, additional, Maruff, Paul, additional, Molinuevo, Jose Luis, additional, Kornhuber, Johannes, additional, Reisberg, Barry, additional, Riedel-Heller, Steffi G., additional, Roehr, Susanne, additional, Sachdev, Perminder S., additional, Scarmeas, Nikolaos, additional, Scheltens, Philip, additional, Visser, Pieter Jelle, additional, Vos, Stephanie J.B., additional, Wagner, Michael, additional, Jessen, Frank, additional, and van der Flier, Wiesje M., additional

Published
2016
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