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1,535 results on '"Shinoda, M."'

212. INCORPORATING II-I RECEPTOR ANTAGONIST SECRETING HEPA-TOCYTES IN A BIOARTIFICIAL LIVER DEVICE FOR THE TREATMENT OF FULMINANT HEPATIC FAILURE

Author

Shinoda, M, primary, Tilles, A W, additional, Wakabayashi, G, additional, Kobayashi, N, additional, Berthia-ume, F, additional, Takayanagi, A, additional, Shimazu, M, additional, Shimizu, N, additional, Tanaka, N, additional, Kitajima, M, additional, Tompkins, R G, additional, Toner, M, additional, and Yarmush, M L, additional

Published
2004
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224. Functional Construction of the Anti--Mucin Core Protein (MUC1) Antibody MUSE11 Variable Regions in a Bacterial Expression System

Author

Asano, R., primary, Takemura, S.-i., additional, Tsumoto, K., additional, Sakurai, N., additional, Teramae, A., additional, Ebara, S., additional, Katayose, Y., additional, Shinoda, M., additional, Suzuki, M., additional, Imai, K., additional, Matsuno, S., additional, Kudo, T., additional, and Kumagai, I., additional

Published
2000
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230. Hemoadsorption of High-Mobility Group Box Chromosomal Protein 1 Using a Column for Large Animals.

Author

Nishiyama, R., Shinoda, M., Tanabe, M., Oshima, G., Takano, K., Miyasho, T., Fuchimoto, Y., Yamada, S., Inoue, T., Shimada, K., Suda, K., Tanaka, M., Hayashida, T., Yagi, H., Kitago, M., Obara, H., Itano, O., Takeuchi, H., Kawachi, S., and Maruyama, I.

Subjects
*INFLAMMATION, *POLYSTYRENE, *LABORATORY swine, *LIVER failure, *HEMOPERFUSION, *THERAPEUTICS
Abstract

Background: High-mobility group box chromosomal protein 1 (HMGB1) has recently been identified as an important mediator of various kinds of acute and chronic inflammation. A method for efficiently removing HMGB1 from thesystemic circulation could be a promising therapy for HMGB1-mediated inflammatory diseases. Materials and Methods: In this study, we produced a new adsorbent material by chemicallytreating polystyrene fiber. We first determined whether the adsorbent material efficiently adsorbed HMGB1 in vitro using a bovine HMGB1 solution and a plasma sample from a swine model of acute liver failure. We then constructed a column by embedding fabric sheets of the newly developed fibers into a cartridge and tested the ability of the column to reduce plasma HMGB1 levels during a 4-hour extracorporeal hemoperfusion in a swine model of acute liver failure. Results: The in vitro adsorption test of the new fiber showed high performance for HMGB1 adsorption (96% adsorption in the bovine HMGB1 solution and 94% in the acute liver failure swine plasma, 2 h incubation at 37°C; p < 0.05 vs. incubation with no adsorbent). In the in vivo study, the ratio of the HMGB1 concentration at the outlet versus the inlet of the column was significantly lower in swine hemoperfused with the newlydeveloped column (53 and 61% at the beginning and end of perfusion, respectively) than in those animals hemoperfused with the control column (94 and 93% at the beginning and end of perfusion, respectively; p < 0.05). Moreover, the normalized plasma level of HMGB1 was significantly lower during perfusion with the new column than with the control column (p < 0.05 at 1, 2, and 3 h after initiation of perfusion). Conclusion: These data suggest that the newly developed column has the potential to effectively adsorb HMGB1 during hemoperfusion in swine. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2014
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243. ChemInform Abstract: Structure‐Activity Relationships of (E)‐3‐(1,4‐Benzoquinonyl)‐2‐((3‐ pyridyl)alkyl)‐2‐propenoic Acid Derivatives That Inhibit Both 5‐ Lipoxygenase and Thromboxane A2 Synthetase.

Author

HIBI, S., primary, OKAMOTO, Y., additional, TAGAMI, K., additional, NUMATA, H., additional, KOBAYASHI, N., additional, SHINODA, M., additional, KAWAHARA, T., additional, HARADA, K., additional, MIYAMOTO, K., additional, and YAMATSU, I., additional

Published
1996
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244. Drug sensitivity testing for clinical samples from oesophageal cancer using adhesive tumour cell culture system

Author

Terashima, M, primary, Hayashi, K, additional, Fukushima, M, additional, Ide, H, additional, Iizuka, T, additional, Kakegawa, T, additional, Ando, N, additional, Tanaka, O, additional, Shinoda, M, additional, Isono, K, additional, Ishida, K, additional, Ikeuchi, S, additional, Endo, M, additional, Takiyama, W, additional, and Yanagawa, T, additional

Published
1996
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249. Optical pick-up for DVD

Author

Shinoda, M., primary, Nakamura, K., additional, Yabe, M., additional, Watanabe, N., additional, Satoh, T., additional, Hirai, N., additional, Fujita, T., additional, Kime, K., additional, and Ishida, Y., additional

Published
1996
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