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793 results on '"Shi, Bing‐Feng"'

238. Synthesis of Bicyclo[ n.1.0]alkanes by a Cobalt-Catalyzed Multiple C(sp3)−H Activation Strategy.

Author

Zhang, Zhuo-Zhuo, Han, Ye-Qiang, Zhan, Bei-Bei, Wang, Sai, and Shi, Bing-Feng

Subjects
ALKANES, ORGANIC synthesis, COBALT catalysts, CARBON-hydrogen bonds, ACTIVATION (Chemistry), HEXANE
Abstract

A cobalt-catalyzed dual C(sp3)−H activation strategy has been developed and it provides a novel strategy for the synthesis of bicyclo[4.1.0]heptanes and bicyclo[3.1.0]hexanes. A key to the success of this reaction is the conformation-induced methylene C(sp3)−H activation of the resulting cobaltabicyclo[4.n.1] intermediate. In addition, the synthesis of bicyclo[3.1.0]hexane from pivalamide, by a triple C(sp3)−H activation, has also been demonstrated. [ABSTRACT FROM AUTHOR]

Published
2017
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239. Cobalt(III)-Catalyzed Alkylation of Primary C( sp3)-H Bonds with Diazo Compounds.

Author

Yan, Sheng ‐ Yi, Ling, Peng ‐ Xiang, and Shi, Bing ‐ Feng

Subjects
COBALT catalysts, ALKYLATION, HYDROGEN bomb, DIAZO compounds, QUINOLINE, FUNCTIONAL groups
Abstract

Chelation-assisted C( sp2)-H metalation/carbenoid insertion has been well investigated. However, the analogous carbene functionalization of C( sp3)-H bonds remains a great challenge. Here we report the first cobalt(III)-catalyzed alkylation of 8-methylquinolines with diazo compounds through primary C( sp3)-H cobaltation/carbenoid insertion. The reaction is highly efficient, scalable and tolerates a variety of functional groups. Furthermore, the unique protocol can be applied to the synthesis of azatricyclic antibiotic compounds. [ABSTRACT FROM AUTHOR]

Published
2017
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240. Palladium-catalyzed sequential monoarylation/amidation of C(sp3)–H bonds: stereoselective synthesis of α-amino-β-lactams and anti-α,β-diamino acid.

Author

Ling, Peng-Xiang, Fang, Sheng-Long, Yin, Xue-Song, Zhang, Qi, Chen, Kai, and Shi, Bing-Feng

Subjects
PALLADIUM catalysts, AMIDATION, AMINO acids
Abstract

Pd-Catalyzed sequential monoarylation/amidation of C(sp3)–H bonds of alanine enabled by a removable 5-methoxyquinolin-8-amine (MQ) auxiliary is described. This process is highly efficient and compatible with a variety of functional groups, providing a general and practical access to various α-amino-β-lactams. The synthetic potential of this protocol is further demonstrated by the stereoselective synthesis of orthogonally protected anti-α,β-diamino acids. [ABSTRACT FROM AUTHOR]

Published
2017
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