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1,536 results on '"Seidman, Michael"'

201. Electrical Modulation of Tinnitus-Related Activity

Author

Zhang, Jinsheng, Guan, Zhenlong, Ramachandran, Virginia, Dunford, Jonathan, Hoa, Michael, Pace, Edward, Mao, Johnny, Seidman, Michael, Elisevich, Kost, Bowyer, Susan, and Jiang, Quan

Published
2008

203. EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2

Author

Nieminuszczy, Jadwiga, Broderick, Ronan, Bellani, Marina, Smethurst, Elizabeth, Schwab, Rebekka, Cherdyntseva, Veronica, Evmorfopoulou, Theodora, Lin, Yea-Lih, Minczuk, Michal, Pasero, Philippe, Gagos, Sarantis, Seidman, Michael, Niedzwiedz, Wojciech, The Institute of Cancer Research, London, UK., Minczuk, Michal [0000-0001-8242-1420], Apollo - University of Cambridge Repository, Institut de génétique humaine (IGH), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio], EXD2, DNA replication, fork regression, BRCA1, BRCA2, EXDL2, ComputingMilieux_MISCELLANEOUS
Abstract

Accurate DNA replication is essential to preserve genomic integrity and prevent chromosomal instability-associated diseases including cancer. Key to this process is the cells' ability to stabilize and restart stalled replication forks. Here, we show that the EXD2 nuclease is essential to this process. EXD2 recruitment to stressed forks suppresses their degradation by restraining excessive fork regression. Accordingly, EXD2 deficiency leads to fork collapse, hypersensitivity to replication inhibitors, and genomic instability. Impeding fork regression by inactivation of SMARCAL1 or removal of RECQ1's inhibition in EXD2-/- cells restores efficient fork restart and genome stability. Moreover, purified EXD2 efficiently processes substrates mimicking regressed forks. Thus, this work identifies a mechanism underpinned by EXD2's nuclease activity, by which cells balance fork regression with fork restoration to maintain genome stability. Interestingly, from a clinical perspective, we discover that EXD2's depletion is synthetic lethal with mutations in BRCA1/2, implying a non-redundant role in replication fork protection.

Published
2019

205. Transcatheter Aortic Heart Valves:Histological Analysis Providing Insight to Leaflet Thickening and Structural Valve Degeneration

Author

Sellers, Stephanie L, Turner, Christopher T, Sathananthan, Janarthanan, Cartlidge, Timothy R G, Sin, Frances, Bouchareb, Rihab, Mooney, John, Nørgaard, Bjarne L, Bax, Jeroen J, Bernatchez, Pascal N, Dweck, Marc R, Granville, David J, Newby, David E, Lauck, Sandra, Webb, John G, Payne, Geoffrey W, Pibarot, Philippe, Blanke, Philipp, Seidman, Michael A, and Leipsic, Jonathon A

Subjects
cardiovascular system
Abstract

OBJECTIVES: This study investigated processes causing leaflet thickening and structural valve degeneration (SVD).BACKGROUND: Although transcatheter aortic valve replacement (TAVR) has changed the treatment of aortic stenosis, concerns remain regarding SVD, potentially related to valve thrombosis and thickening, based on studies using computed tomography (CT). Detailed histological analyses are provided to help attain insights into these processes.METHODS: Explanted transcatheter heart valves (THVs) were evaluated for thrombosis, fibrosis, and calcification for quantification of leaflet thickness. Immunohistochemical and microscopy approaches were used to investigate SVD-associated mechanisms.RESULTS: THVs (n = 23) were obtained from 22 patients (median 81 years of age; 50% male) from 0 to 2,583 days post TAVR. Maximal leaflet thickness increased relative to implant duration (ρ = 0.427; p = 0.027). THVs explanted after >2 years were thicker than those explanted after CONCLUSIONS: There is a time-dependent degeneration of THVs consisting of thrombus formation, endothelial hyperplasia, fibrosis, tissue remodeling, proteinase expression, and calcification. Future investigation is needed to further understand these mechanisms contributing to leaflet thickening and SVD.

Published
2018

231. The unorwellian Barcelona

Author

Seidman, Michael

Subjects
Spanish Civil War, 1936-1939, in literature -- Criticism and interpretation, Labor unions -- Spain, History, Regional focus/area studies
Published
1990

233. Reviews of Books

Author

Clúa Serena, Josep Antoni, primary, Maura, Juan Francisco, additional, Beusterien, John, additional, Ruán, Felipe E., additional, Breden, Simon, additional, Fernández, Esther, additional, Harkema, Leslie J., additional, Longhurst, C. A., additional, Seidman, Michael, additional, Evans, Danny, additional, Grocott, Chris, additional, Laraway, David, additional, Fontes da Costa, Palmira, additional, Tavárez, David, additional, Cabrera, Eduardo, additional, Henighan, Stephen, additional, and Briggs, Ronald, additional

Published
2019
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234. Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy

Author

Park, Youngran, primary, Chui, M. Herman, additional, Suryo Rahmanto, Yohan, additional, Yu, Zheng-Cheng, additional, Shamanna, Raghavendra A., additional, Bellani, Marina A., additional, Gaillard, Stephanie, additional, Ayhan, Ayse, additional, Viswanathan, Akila, additional, Seidman, Michael M., additional, Franco, Sonia, additional, Leung, Anthony K.L., additional, Bohr, Vilhelm A., additional, Shih, Ie-Ming, additional, and Wang, Tian-Li, additional

Published
2019
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238. Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2

Author

Huang, Jing, primary, Zhang, Jing, additional, Bellani, Marina A., additional, Pokharel, Durga, additional, Gichimu, Julia, additional, James, Ryan C., additional, Gali, Himabindu, additional, Ling, Chen, additional, Yan, Zhijiang, additional, Xu, Dongyi, additional, Chen, Junjie, additional, Meetei, Amom Ruhikanta, additional, Li, Lei, additional, Wang, Weidong, additional, and Seidman, Michael M., additional

Published
2019
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239. The Authors Reply

Author

Sellers, Stephanie L., primary, Payne, Geoffrey W., additional, Seidman, Michael A., additional, and Leipsic, Jonathon A., additional

Published
2019
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240. Interdisciplinary Approach to an Unusual Case of Myocarditis in Pregnancy

Author

Marceau, Aude, primary, McGinnis, Justin M., additional, Derakhshan, Fatemeh, additional, Liu, Yi Ariel, additional, Sathananthan, Gnalini, additional, Sosa Cazales, Ana Clara, additional, Grewal, Jasmine, additional, Ignaszewski, Andrew, additional, Joa, Elisabet, additional, Luong, Michael, additional, Toma, Mustafa, additional, Virani, Sean A., additional, and Seidman, Michael A., additional

Published
2019
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242. Transcatheter Aortic Heart Valves

Author

Sellers, Stephanie L., primary, Turner, Christopher T., additional, Sathananthan, Janarthanan, additional, Cartlidge, Timothy R.G., additional, Sin, Frances, additional, Bouchareb, Rihab, additional, Mooney, John, additional, Nørgaard, Bjarne L., additional, Bax, Jeroen J., additional, Bernatchez, Pascal N., additional, Dweck, Marc R., additional, Granville, David J., additional, Newby, David E., additional, Lauck, Sandra, additional, Webb, John G., additional, Payne, Geoffrey W., additional, Pibarot, Philippe, additional, Blanke, Philipp, additional, Seidman, Michael A., additional, and Leipsic, Jonathon A., additional

Published
2019
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243. IN MEMORIAM.

Author

Clark, Emily, Seidman, Michael, Kelley, Robin D. G., Pestana, Carla Gardina, and Godbold Jr., E. Stanly

Subjects
CITY dwellers, PARENTS, UNIVERSITY faculty, SOCIAL theory, LEGAL judgments, GRANDPARENTS
Published
2021

248. Recurrent Myocarditis Induced by Immune-Checkpoint Inhibitor Treatment Is Accompanied by Persistent Inflammatory Markers Despite Immunosuppressive Treatment.

Author

Aghel, Nazanin, Gustafson, Dakota, Di Meo, Ashley, Music, Milena, Prassas, Ioannis, Seidman, Michael A., Hansen, Aaron R., Thavendiranathan, Paaladinesh, Diamandis, Eleftherios P., Delgado, Diego, and Fish, Jason E.

Subjects
IMMUNE checkpoint inhibitors, MYOCARDITIS, AUTOIMMUNE diseases, PHYSICIANS, CHEST pain, IMMUNE checkpoint proteins, DRUG side effects
Abstract

Multiplex analysis of cytokines (Luminex, Austin, TX) in serum revealed remarkably high concentrations of T-cell-derived cytokines during recurrence despite withdrawal of ICI therapy and initiation of immunosuppressants. Serum autoantibody complexes were observed consistently in the programmed cell death protein-1 ligand 1-induced fulminant myocarditis patient compared to age- and sex-matched control patients (n = 7), and a patient with myocarditis from systemic lupus erythematosus (n = 1; D). Keywords: Immune related myocarditis; Immune checkpoint inhibitors; Autoantibodies; Recurrent disease; Presentations; Troponin; Programmed death ligand 1; heparin; prednisone; methylprednisolone; mycophenolic acid; interferon; fluorouracil; epirubicin; durvalumab; cyclophosphamide EN Immune related myocarditis Immune checkpoint inhibitors Autoantibodies Recurrent disease Presentations Troponin Programmed death ligand 1 heparin prednisone methylprednisolone mycophenolic acid interferon fluorouracil epirubicin durvalumab cyclophosphamide 485 491 7 11/03/21 20210510 NES 210510 INTRODUCTION Immune checkpoint inhibitors (ICIs) have significantly improved advanced cancer outcomes.[1],[2] Although ICIs unleash antitumor immune responses, negating natural immune inhibitory mechanisms can result in the development of self-reactive immune cells and an array of immune-related adverse events (irAEs).[3] Although reports of serious myocarditis have emerged,[4] [9] data on long-term outcomes following an episode of ICI-associated myocarditis are limited and molecular analyses on surviving patients are lacking. [Extracted from the article]

Published
2021
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250. Defective DNA Repair in Humans: Clinical and Molecular Studies of Xeroderma Pigmentosum

Author

Kraemer, Kenneth H., primary, Seetharam, Saraswathy, additional, Seidman, Michael M., additional, Bredberg, Anders, additional, Brash, Douglas, additional, Waters, Haywood L., additional, Protić-Sablijć, Miroslava, additional, Peck, Gary, additional, DiGiovanna, John, additional, Moshell, Alan, additional, Tarone, Robert E., additional, Jones, Gary, additional, Parshad, Ram, additional, and Sanford, Katherine, additional

Published
1990
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