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202. Buchbesprechungen

Author

Epprecht, W., primary, Henrici, P., additional, Haller, P., additional, Baldinger, E., additional, Gränacher, I., additional, Weber, H., additional, Saxer, W., additional, Schmid, P., additional, and Schumann, W., additional

Published
1965
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204. Besprechungen

Author

Hopf, L., primary, Wieselsberger, C., additional, Schumann, W. O., additional, Siebel, E., additional, Seeliger, R., additional, and Funk, W., additional

Published
1934
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229. Buchbesprechungen

Author

Stiefel, E., primary, Saxer, W., additional, Gerber, W., additional, Rutishauser, H., additional, Junod, P., additional, Hochstrasser, U., additional, Furrer, W., additional, Epprecht, G., additional, Clavuot, Ch., additional, and Schumann, W., additional

Published
1963
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230. Besprechungen

Author

Schumann, W. O., primary, Pringsheim, Peter, additional, Glocker, R., additional, Rogowski, W., additional, Mahnkopf, H., additional, Meissner, A., additional, Blumenthal, O., additional, Funk, W., additional, Hopf, L., additional, Kneser, H., additional, Hertz, P., additional, Drenckhahn, Friedrich, additional, and Baur, Emil, additional

Published
1924
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232. Buchbesprechungen

Author

Roth-Desmeules, E., primary, Waldmeier, M., additional, Grassmann, P., additional, Rossel, J., additional, Schmid, P., additional, Weber, H., additional, Künzi, H. P., additional, Wallertshauser, H. R., additional, Baldinger, E., additional, Ziegler, H., additional, Haller, P., additional, Bas, E., additional, Wilhelm, R., additional, Kupper, J., additional, and Schumann, W., additional

Published
1962
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238. BESPRECHUNGEN

Author

Schmeidler, F., primary, Waldmann, L., additional, Schumann, W. O., additional, and Menzel, Erich, additional

Published
1950
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242. Besprechungen

Author

Touton, K., primary, Müller, Rolf, additional, Baschin, O., additional, Glocker, R., additional, Ewald, P. P., additional, Schumann, W. O., additional, Kolhörster, Werner, additional, Prandtl, L., additional, Eitel, W., additional, v. Bubnoff, S., additional, Kramers, H. A., additional, and Pöschl, Th., additional

Published
1927
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250. Gluconeogenesis and glucuronidation in liver in vivo and the heterogeneity of hepatocyte function.

Author

Ekberg, K, Chandramouli, V, Kumaran, K, Schumann, W C, Wahren, J, and Landau, B R

Abstract

In order to examine metabolic zonation in human liver, [2-14C]glycerol, which labels carbons 2 and 5 of glucose-6-P, and [1-14C]lactate, which labels carbons 3 and 4 of glucose-6-P, in the process of gluconeogenesis, were infused intravenously into healthy subjects who ingested acetaminophen and had fasted 36 h. Distributions of 14C were determined in glucose in blood and in the glucuronic acid moiety of acetaminophen glucuronide excreted in urine. Ratios of 14C in carbons 2 and 5 to 14C in carbons 3 and 4 were significantly higher in blood glucose than in glucuronide. Since glucose and glucuronic acid are formed from glucose-6-P in liver without randomization of carbon, the differences in the ratios indicate that the pool of glucose-6-P in liver is not homogeneous. The glucuronide sampled glucose-6-P with more label from lactate than glycerol compared to the glucose-6-P sampled by the glucose. The apparent explanation is the greater decrease in glycerol compared with lactate concentration as blood streams from the periportal to the perivenous zones of the liver lobule. Glucuronidation is then expressed in humans relatively more in the perivenous than periportal zones and gluconeogenesis from glycerol more in the periportal than perivenous zones.

Published
1995

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