1,816 results on '"Schulze, Thomas"'
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202. TH22. IDENTIFICATION OF IMMUNE-RELATED SERUM PROTEINS ASSOCIATED WITH GENETIC RISK OF BIPOLAR DISORDER
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Kohshour, Mojtaba Oraki, primary, Papiol, Sergi, additional, Just, David, additional, Kannaiyan, Nirmal Raman, additional, Budde, Monika, additional, Heilbronner, Urs, additional, Kalman, Janos, additional, Schulte, Eva, additional, Rietschel, Marcella, additional, Nöthen, Markus, additional, Rossner, Moritz, additional, Falkai, Peter, additional, Nilsson, Peter, additional, and Schulze, Thomas G., additional
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- 2021
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203. W39. EVALUATION OF THE ASSOCIATION BETWEEN SERUM PROTEINS AND NEUROCOGNITIVE PERFORMANCE IN BIPOLAR DISORDER AND SCHIZOPHRENIA PATIENTS
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Kohshour, Mojtaba Oraki, primary, Papiol, Sergi, additional, Just, David, additional, Kannaiyan, Nirmal Raman, additional, Budde, Monika, additional, Heilbronner, Urs, additional, Kalman, Janos, additional, Schulte, Eva, additional, Rietschel, Marcella, additional, Nöthen, Markus, additional, Rossner, Moritz, additional, Falkai, Peter, additional, Nilsson, Peter, additional, and Schulze, Thomas G., additional
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- 2021
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204. TH69. COMBINING SCHIZOPHRENIA AND DEPRESSION POLYGENIC RISK SCORES (PRS) IMPROVES THE GENETIC PREDICTION OF LITHIUM RESPONSE IN BIPOLAR DISORDER PATIENTS
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Amare, Azmeraw, primary, Schubert, Klaus Oliver, additional, Thalamuthu, Anbupalam, additional, Clark, Scott, additional, Schulze, Thomas G., additional, Rietschel, Marcella, additional, and Baune, Bernhard, additional
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- 2021
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205. TU80. GENOME-WIDE ASSOCIATION META-ANALYSIS OF AGE AT ONSET IN SCHIZOPHRENIA IN EUROPEAN POPULATIONS
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Fuente, Ester Sada, primary, Cuadrada, Elisabet Vilella, additional, Papiol, Sergi, additional, Schulze, Thomas G., additional, Heilbronner, Urs, additional, Kalman, Janos, additional, and Medina, Gerard Muntané, additional
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- 2021
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206. Stability over time of psychiatric rating scales and questionnaires, but not cognitive tests, in healthy individuals of the PsyCourse Study
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Stahl, Katharina, Adorjan, Kristina, Anderson-Schmidt, Heike, Budde, Monika, Comes, Ashley L., Gade, Katrin, Heilbronner, Maria, Kalman, Janos L., Klöhn-Saghatolislam, Farahnaz, Oraki Kohshour, Mojtaba, Papiol, Sergi, Reich-Erkelenz, Daniela, Schaupp, Sabrina K., Schulte, Eva C., Senner, Fanny, Vogl, Thomas, Wiltfang, Jens, Reininghaus, Eva, Falkai, Peter, Schulze, Thomas G., Bickeböller, Heike, and Heilbronner, Urs
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schizophrenia ,bipolar disorder ,psychiatric rating ,ddc: 610 ,Medicine and health ,depression ,neuropsychology ,controls ,longitudinal course - Abstract
Introduction: Developing therapies for long-term alleviation of severe mental disorders is a major global task. The affected individuals experience a broad range of symptoms, oftentimes including cognitive impairments. To accurately evaluate changes in psychiatric symptoms and cognition in patients [for full text, please go to the a.m. URL]
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- 2021
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207. The “DGPPN-Cohort”: a national collaboration initiative by the German Association for Psychiatry and Psychotherapy (DGPPN) for establishing a large-scale cohort of psychiatric patients
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Anderson-Schmidt, Heike, Adler, Lothar, Aly, Chadiga, Anghelescu, Ion-George, Bauer, Michael, Baumgärtner, Jessica, Becker, Joachim, Bianco, Roswitha, Becker, Thomas, Bitter, Cosima, Bönsch, Dominikus, Buckow, Karoline, Budde, Monika, Bührig, Martin, Deckert, Jürgen, Demiroglu, Sara Y., Dietrich, Detlef, Dümpelmann, Michael, Engelhardt, Uta, Fallgatter, Andreas J., Feldhaus, Daniel, Figge, Christian, Folkerts, Here, Franz, Michael, Gade, Katrin, Gaebel, Wolfgang, Grabe, Hans-Jörgen, Gruber, Oliver, Gullatz, Verena, Gusky, Linda, Heilbronner, Urs, Helbing, Krister, Hegerl, Ulrich, Heinz, Andreas, Hensch, Tilman, Hiemke, Christoph, Jäger, Markus, Jahn-Brodmann, Anke, Juckel, Georg, Kandulski, Franz, Kaschka, Wolfgang P., Kircher, Tilo, Koller, Manfred, Konrad, Carsten, Kornhuber, Johannes, Krause, Marina, Krug, Axel, Lee, Mahsa, Leweke, Markus, Lieb, Klaus, Mammes, Mechthild, Meyer-Lindenberg, Andreas, Mühlbacher, Moritz, Müller, Matthias J., Nieratschker, Vanessa, Nierste, Barbara, Ohle, Jacqueline, Pfennig, Andrea, Pieper, Marlenna, Quade, Matthias, Reich-Erkelenz, Daniela, Reif, Andreas, Reitt, Markus, Reininghaus, Bernd, Reininghaus, Eva Z., Riemenschneider, Matthias, Rienhoff, Otto, Roser, Patrik, Rujescu, Dan, Schennach, Rebecca, Scherk, Harald, Schmauss, Max, Schneider, Frank, Schosser, Alexandra, Schott, Björn H., Schwab, Sybille G., Schwanke, Jens, Skrowny, Daniela, Spitzer, Carsten, Stierl, Sebastian, Stöckel, Judith, Stübner, Susanne, Thiel, Andreas, Volz, Hans-Peter, von Hagen, Martin, Walter, Henrik, Witt, Stephanie H., Wobrock, Thomas, Zielasek, Jürgen, Zimmermann, Jörg, Zitzelsberger, Antje, Maier, Wolfgang, Falkai, Peter G., Rietschel, Marcella, and Schulze, Thomas G.
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- 2013
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208. Green Specifications
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Schulze, Thomas, primary and Atkinson, Colin, additional
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- 2015
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209. Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function
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Luo, Xiong-Jian, Mattheisen, Manuel, Li, Ming, Huang, Liang, Rietschel, Marcella, Børglum, Anders D., Als, Thomas D., van den Oord, Edwin J., Aberg, Karolina A., Mors, Ole, Mortensen, Preben Bo, Luo, Zhenwu, Degenhardt, Franziska, Cichon, Sven, Schulze, Thomas G., Nöthen, Markus M., Su, Bing, Zhao, Zhongming, Gan, Lin, and Yao, Yong-Gang
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- 2015
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210. Introduction
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McMahon, Francis J., Schulze, Thomas G., and Gordon, Derek
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- 2004
211. Computer-Assisted Phenotype Characterization for Genetic Research in Psychiatry
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Fangerau, Heiner, Ohlraun, Stephanie, Granath, Ralf O., Nöthen, Markus M., Rietschel, Marcella, and Schulze, Thomas G.
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- 2004
212. Defining the Phenotype in Human Genetic Studies : Forward Genetics and Reverse Phenotyping
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Schulze, Thomas G. and McMahon, Francis J.
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- 2004
213. The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: Findings from a large German case-control and family-based sample
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Nieratschker, Vanessa, Frank, Josef, Mühleisen, Thomas W., Strohmaier, Jana, Wendland, Jens R., Schumacher, Johannes, Treutlein, Jens, Breuer, René, Jamra, Rami Abou, Mattheisen, Manuel, Herms, Stefan, Schmäl, Christine, Maier, Wolfgang, Nöthen, Markus M., Cichon, Sven, Rietschel, Marcella, and Schulze, Thomas G.
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- 2010
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214. A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case–control and family-based sample of German ancestry
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Strohmaier, Jana, Frank, Josef, Wendland, Jens R., Schumacher, Johannes, Jamra, Rami Abou, Treutlein, Jens, Nieratschker, Vanessa, Breuer, René, Mattheisen, Manuel, Herms, Stefan, Mühleisen, Thomas W., Maier, Wolfgang, Nöthen, Markus M., Cichon, Sven, Rietschel, Marcella, and Schulze, Thomas G.
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- 2010
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215. Genetic Research into Bipolar Disorder: The Need for a Research Framework that Integrates Sophisticated Molecular Biology and Clinically Informed Phenotype Characterization
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Schulze, Thomas G.
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- 2010
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216. Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders
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Andlauer, Till F M, Guzman-Parra, Jose, Orozco Diaz, Guillermo, Freimer, Nelson B, Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartolomei, Claudia, Pedersen, Marianne Giørtz, Goldstein, Jaqueline, Gordon, Scott D, Gordon-Smith, Katherine, de Diego-Otero, Yolanda, Green, Elaine K, Green, Melissa J, Greenwood, Tiffany A, Grove, Jakob, Guan, Weihua, Parra, José Guzman, Hamshere, Marian L, Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Moreno-Küstner, Berta, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S, Juréus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L, Auburger, Georg, Kittel-Schneider, Sarah, Knowles, James A, Kogevinas, Manolis, Koller, Anna C, Kupka, Ralph, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B, Leber, Markus, Lee, Phil H, Degenhardt, Franziska, Levy, Shawn E, Li, Jun Z, Liu, Chunyu, Lucae, Susanne, Maaser, Anna, MacIntyre, Donald J, Mahon, Pamela B, Maier, Wolfgang, Martinsson, Lina, McCarroll, Steve, Heilmann-Heimbach, Stefanie, McGuffin, Peter, McInnis, Melvin G, McKay, James D, Medeiros, Helena, Medland, Sarah E, Meng, Fan, Milani, Lili, Montgomery, Grant W, Morris, Derek W, Mühleisen, Thomas W, Mullins, Niamh, Nguyen, Hoang, Nievergelt, Caroline M, Adolfsson, Annelie Nordin, Nwulia, Evaristus A, O'Donovan, Claire, Loohuis, Loes M Olde, Ori, Anil P S, Oruc, Lilijana, Ösby, Urban, Perlis, Roy H, Perry, Amy, Pfennig, Andrea, Potash, James B, Purcell, Shaun M, Regeer, Eline J, Reif, Andreas, Reinbold, Céline S, Rice, John P, Richards, Alexander L, Frank, Josef, Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M, Ryu, Euijung, Sánchez-Mora, Cristina, Schatzberg, Alan F, Scheftner, William A, Schork, Nicholas J, Weickert, Cynthia Shannon, Foo, Jerome C, Shehktman, Tatyana, Shilling, Paul D, Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav B, Sobell, Janet L, Hansen, Christine Søholm, Spijker, Anne T, Clair, David St, Steffens, Michael, Streit, Fabian, Treutlein, Jens, Strauss, John S, Strohmaier, Jana, Szelinger, Szabolcs, Thompson, Robert C, EThorgeirsson, Thorgeir, Vedde, Helmut, Wang, Weiqing, Watson, Stanley J, Witt, Stephanie H, Weickert, Thomas W, Xi, Simon, Xu, Wei, Young, Allan H, Zandi, Peter, Zhang, Peng, Zollner, Sebastian, Adolfsson, Rolf, Agartz, Ingrid, Cichon, Sven, Alda, Martin, Backlund, Lena, Baune, Bernhard T, Bellivier, Frank, Berrettini, Wade H, Biernacka, Joanna M, Blackwood, Douglas H R, Boehnke, Michael, Børglum, Anders D, Corvin, Aiden, Craddock, Nicholas, Daly, Mark J, Dannlowski, Udo, Esko, Tõnu, Etain, Bruno, Frye, Mark, Fullerton, Janice M, Gershon, Elliot S, Gill, Michael, Goes, Fernando, Grigoroiu-Serbanescu, Maria, Hauser, Joanna, Hougaard, David M, Hultman, Christina M, Jones, Ian, Jones, Lisa A, Kahn, René S, Kirov, George, Landén, Mikael, Leboyer, Marion, Mayoral, Fermín, Lewis, Cathryn M, Li, Qingqin S, Lissowska, Jolanta, Martin, Nicholas G, Mayoral, Fermin, McElroy, Susan L, McIntosh, Andrew M, McMahon, Francis J, Melle, Ingrid, Metspalu, Andres, Müller-Myhsok, Bertram, Mitchell, Philip B, Morken, Gunnar, Mors, Ole, Mortensen, Preben Bo, Myers, Richard M, Neale, Benjamin M, Nimgaonkar, Vishwajit, Nordentoft, Merete, Nöthen, Markus M, Forstner, Andreas J, O'Donovan, Michael C, Oedegaard, Ketil J, Owen, Michael J, Paciga, Sara A, Pato, Carlos, Pato, Michele T, Posthuma, Danielle, Ramos-Quiroga, Josep Antoni, Ribasés, Marta, Rietschel, Marcella, Rouleau, Guy A, Schalling, Martin, Schofield, Peter R, Schulze, Thomas G, Serretti, Alessandro, Smoller, Jordan W, Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Sullivan, Patrick F, Turecki, Gustavo, Vaaler, Arne E, Vieta, Eduard, Vincent, John B, Werge, Thomas, Nurnberger, John I, Wray, Naomi R, Florio, Arianna Di, Edenberg, Howard J, Stahl, Eli A, Ophoff, Roel A, Scott, Laura J, Andreassen, Ole A, Kelsoe, John, Sklar, Pamela, Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M, Breen, Gerome, Abdellaoui, Abdel, Adams, Mark J, Agerbo, Esben, Air, Tracy M, Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T F, Bigdeli, Tim B, Binder, Elisabeth B, Bryois, Julien, Buttenschøn, Henriette N, Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan R I, Colodro-Conde, Lucía, Couvy-Duchesne, Baptiste, McQuillin, Andrew, Craddock, Nick, Crawford, Gregory E, Davies, Gail, Deary, Ian J, Derks, Eske M, Direk, Nese, Dolan, Conor V, Dunn, Erin C, Eley, Thalia C, Escott-Price, Valentina, Kiadeh, Farnush Farhadi Hassan, Finucane, Hilary K, Gaspar, Héléna A, Goes, Fernando S, Trubetskoy, Vassily, Hall, Lynsey S, Hansen, Thomas F, Hickie, Ian B, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Howard, David M, Ising, Marcus, Jansen, Rick, Jorgenson, Eric, Kohane, Isaac S, Kraft, Julia, Wang, Yunpeng, Kretzschmar, Warren W, Kutalik, Zoltán, Li, Yihan, Lind, Penelope A, MacKinnon, Dean F, Maier, Robert M, Marchini, Jonathan, Mbarek, Hamdi, McGrath, Patrick, Mehta, Divya, Middeldorp, Christel M, Mihailov, Evelin, Milaneschi, Yuri, Mondimore, Francis M, Mostafavi, Sara, Nauck, Matthias, Ng, Bernard, Nivard, Michel G, Nyholt, Dale R, O'Reilly, Paul F, Oskarsson, Hogni, Painter, Jodie N, González, Maria José, de Leeuw, Christiaan A, Pedersen, Carsten Bøcker, Peterson, Roseann E, Pettersson, Erik, Peyrot, Wouter J, Pistis, Giorgio, Quiroz, Jorge A, Qvist, Per, Steinberg, Stacy, Riley, Brien P, Mirza, Saira Saeed, Schoevers, Robert, Schulte, Eva C, Shen, Ling, Shi, Jianxin, Shyn, Stanley I, Sinnamon, Grant C B, Pavlides, Jennifer M Whitehead, Smit, Johannes H, Smith, Daniel J, Tansey, Katherine E, Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A, Thorgeirsson, Thorgeir E, Traylor, Matthew, Uitterlinden, André G, Umbricht, Daniel, Van der Auwera, Sandra, van Hemert, Albert M, Viktorin, Alexander, Pers, Tune H, Visscher, Peter M, Webb, Bradley T, Weinsheimer, Shantel Marie, Wellmann, Jürgen, Willemsen, Gonneke, Wu, Yang, Xi, Hualin S, Yang, Jian, Holmans, Peter A, Zhang, Futao, Arolt, Volker, Berger, Klaus, Boomsma, Dorret I, de Geus, E. J. C., DePaulo, J Raymond, Domenici, Enrico, Abbott, Liam, Domschke, Katharina, Grabe, Hans J, Hamilton, Steven P, Hayward, Caroline, Heath, Andrew C, Kendler, Kenneth S, Kloiber, Stefan, Lewis, Glyn, Madden, Pamela A F, Magnusson, Patrik K, Akil, Huda, Pedersen, Nancy L, Penninx, Brenda W J H, Porteous, David J, Preisig, Martin, Albani, Diego, Schaefer, Catherine, Tiemeier, Henning, Uher, Rudolf, Völzke, Henry, Weissman, Myrna M, Gil Flores, Susana, Alliey-Rodriguez, Ney, Levinson, Douglas F, Als, Thomas D, Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A, Barchas, Jack D, Bass, Nicholas, Bauer, Michael, Cabaleiro Fabeiro, Francisco J, Belliveau, Richard, Bergen, Sarah E, Bøen, Erlend, Boks, Marco, Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Del Río Noriega, Francisco, Byerley, William, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alexander W, Chen, Danfeng, Churchhouse, Claire, Coryell, William, Perez, Fermin Perez, Craig, David W, Cruceanu, Cristiana, Czerski, Piotr M, Dale, Anders M, de Jong, Simone, Del-Favero, Jurgen, Djurovic, Srdjan, Dobbyn, Amanda L, Haro González, Jesus, Dumont, Ashley, Elvsåshagen, Torbjørn, Fan, Chun Chieh, Fischer, Sascha B, Flickinger, Matthew, Foroud, Tatiana M, Forty, Liz, Fraser, Christine, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Complex Trait Genetics, Epidemiology and Data Science, APH - Digital Health, Andlauer T.F.M., Guzman-Parra J., Streit F., Strohmaier J., Gonzalez M.J., Gil Flores S., Cabaleiro Fabeiro F.J., del Rio Noriega F., Perez F.P., Haro Gonzalez J., Orozco Diaz G., de Diego-Otero Y., Moreno-Kustner B., Auburger G., Degenhardt F., Heilmann-Heimbach S., Herms S., Hoffmann P., Frank J., Foo J.C., Treutlein J., Witt S.H., Cichon S., Kogevinas M., Stahl E.A., Breen G., Forstner A.J., McQuillin A., Ripke S., Trubetskoy V., Mattheisen M., Wang Y., Coleman J.R.I., Gaspar H.A., de Leeuw C.A., Steinberg S., Pavlides J.M.W., Trzaskowski M., Pers T.H., Holmans P.A., Abbott L., Agerbo E., Akil H., Albani D., Alliey-Rodriguez N., Als T.D., Anjorin A., Antilla V., Awasthi S., Badner J.A., Baekvad-Hansen M., Barchas J.D., Bass N., Bauer M., Belliveau R., Bergen S.E., Pedersen C.B., Boen E., Boks M., Boocock J., Budde M., Bunney W., Burmeister M., Bybjerg-Grauholm J., Byerley W., Casas M., Cerrato F., Cervantes P., Chambert K., Charney A.W., Chen D., Churchhouse C., Clarke T.-K., Coryell W., Craig D.W., Cruceanu C., Czerski P.M., Dale A.M., de Jong S., Del-Favero J., DePaulo J.R., Djurovic S., Dobbyn A.L., Dumont A., Elvsashagen T., Escott-Price V., Fan C.C., Fischer S.B., Flickinger M., Foroud T.M., Forty L., Fraser C., Freimer N.B., Frisen L., Gade K., Gage D., Garnham J., Giambartolomei C., Pedersen M.G., Goldstein J., Gordon S.D., Gordon-Smith K., Green E.K., Green M.J., Greenwood T.A., Grove J., Guan W., Parra J.G., Hamshere M.L., Hautzinger M., Heilbronner U., Hipolito M., Holland D., Huckins L., Jamain S., Johnson J.S., Jureus A., Kandaswamy R., Karlsson R., Kennedy J.L., Kittel-Schneider S., Knowles J.A., Koller A.C., Kupka R., Lavebratt C., Lawrence J., Lawson W.B., Leber M., Lee P.H., Levy S.E., Li J.Z., Liu C., Lucae S., Maaser A., MacIntyre D.J., Mahon P.B., Maier W., Martinsson L., McCarroll S., McGuffin P., McInnis M.G., McKay J.D., Medeiros H., Medland S.E., Meng F., Milani L., Montgomery G.W., Morris D.W., Muhleisen T.W., Mullins N., Nguyen H., Nievergelt C.M., Adolfsson A.N., Nwulia E.A., O'Donovan C., Loohuis L.M.O., Ori A.P.S., Oruc L., Osby U., Perlis R.H., Perry A., Pfennig A., Potash J.B., Purcell S.M., Regeer E.J., Reif A., Reinbold C.S., Rice J.P., Richards A.L., Rivas F., Rivera M., Roussos P., Ruderfer D.M., Ryu E., Sanchez-Mora C., Schatzberg A.F., Scheftner W.A., Schork N.J., Weickert C.S., Shehktman T., Shilling P.D., Sigurdsson E., Slaney C., Smeland O.B., Sobell J.L., Hansen C.S., Spijker A.T., Clair D.S., Steffens M., Strauss J.S., Szelinger S., Thompson R.C., EThorgeirsson T., Vedde H., Wang W., Watson S.J., Weickert T.W., Xi S., Xu W., Young A.H., Zandi P., Zhang P., Zollner S., Adolfsson R., Agartz I., Alda M., Backlund L., Baune B.T., Bellivier F., Berrettini W.H., Biernacka J.M., Blackwood D.H.R., Boehnke M., Borglum A.D., Corvin A., Craddock N., Daly M.J., Dannlowski U., Esko T., Etain B., Frye M., Fullerton J.M., Gershon E.S., Gill M., Goes F., Grigoroiu-Serbanescu M., Hauser J., Hougaard D.M., Hultman C.M., Jones I., Jones L.A., Kahn R.S., Kirov G., Landen M., Leboyer M., Lewis C.M., Li Q.S., Lissowska J., Martin N.G., Mayoral F., McElroy S.L., McIntosh A.M., McMahon F.J., Melle I., Metspalu A., Mitchell P.B., Morken G., Mors O., Mortensen P.B., Muller-Myhsok B., Myers R.M., Neale B.M., Nimgaonkar V., Nordentoft M., Nothen M.M., O'Donovan M.C., Oedegaard K.J., Owen M.J., Paciga S.A., Pato C., Pato M.T., Posthuma D., Ramos-Quiroga J.A., Ribases M., Rietschel M., Rouleau G.A., Schalling M., Schofield P.R., Schulze T.G., Serretti A., Smoller J.W., Stefansson H., Stefansson K., Stordal E., Sullivan P.F., Turecki G., Vaaler A.E., Vieta E., Vincent J.B., Werge T., Nurnberger J.I., Wray N.R., Florio A.D., Edenberg H.J., Ophoff R.A., Scott L.J., Andreassen O.A., Kelsoe J., Sklar P., Byrne E.M., Abdellaoui A., Adams M.J., Air T.M., Bacanu S.-A., Beekman A.T.F., Bigdeli T.B., Binder E.B., Bryois J., Buttenschon H.N., Cai N., Castelao E., Christensen J.H., Colodro-Conde L., Couvy-Duchesne B., Crawford G.E., Davies G., Deary I.J., Derks E.M., Direk N., Dolan C.V., Dunn E.C., Eley T.C., Kiadeh F.F.H., Finucane H.K., Goes F.S., Hall L.S., Hansen T.F., Hickie I.B., Homuth G., Horn C., Hottenga J.-J., Howard D.M., Ising M., Jansen R., Jorgenson E., Kohane I.S., Hill, Kraft J., Kretzschmar W.W., Kutalik Z., Li Y., Lind P.A., MacKinnon D.F., Maier R.M., Marchini J., Mbarek H., McGrath P., Mehta D., Middeldorp C.M., Mihailov E., Milaneschi Y., Mondimore F.M., Mostafavi S., Nauck M., Ng B., Nivard M.G., Nyholt D.R., O'Reilly P.F., Oskarsson H., Painter J.N., Peterson R.E., Pettersson E., Peyrot W.J., Pistis G., Quiroz J.A., Qvist P., Riley B.P., Mirza S.S., Schoevers R., Schulte E.C., Shen L., Shi J., Shyn S.I., Sinnamon G.C.B., Smit J.H., Smith D.J., Tansey K.E., Teismann H., Teumer A., Thompson W., Thomson P.A., Thorgeirsson T.E., Traylor M., Uitterlinden A.G., Umbricht D., Van der Auwera S., van Hemert A.M., Viktorin A., Visscher P.M., Webb B.T., Weinsheimer S.M., Wellmann J., Willemsen G., Wu Y., Xi H.S., Yang J., Zhang F., Arolt V., Berger K., Boomsma D.I., de Geus E.J.C., Domenici E., Domschke K., Grabe H.J., Hamilton S.P., Hayward C., Heath A.C., Kendler K.S., Kloiber S., Lewis G., Madden P.A.F., Magnusson P.K., Pedersen N.L., Penninx B.W.J.H., Porteous D.J., Preisig M., Schaefer C., Tiemeier H., Uher R., Volzke H., Weissman M.M., Levinson D.F., Child and Adolescent Psychiatry / Psychology, Epidemiology, Internal Medicine, Clinical Cognitive Neuropsychiatry Research Program (CCNP), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, APH - Methodology, Biological Psychology, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Complex Trait Genetics, and Adult Psychiatry
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Netherlands Twin Register (NTR) ,Genetic variants ,Bipolar Disorder ,Specific risk ,Disease ,0302 clinical medicine ,Multiplex ,Genetic risk ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,Depression (differential diagnoses) ,0303 health sciences ,Depression ,ddc ,3. Good health ,Geðraskanir ,Psychiatry and Mental health ,Schizophrenia ,Cohort ,Major depressive disorder ,Case-Control Studie ,Human ,medicine.medical_specialty ,Bipolar disorder ,Article ,Cellular and Molecular Neuroscience ,03 medical and health sciences ,Geðklofi ,SDG 3 - Good Health and Well-being ,medicine ,Humans ,Genetic Predisposition to Disease ,ddc:610 ,Psychiatry ,Þunglyndi ,Molecular Biology ,030304 developmental biology ,Depressive Disorder, Major ,Geðhvarfasýki ,business.industry ,Psychiatric disorder ,medicine.disease ,Genarannsóknir ,Case-Control Studies ,Multiple comparisons problem ,business ,030217 neurology & neurosurgery - Abstract
Publisher's version, Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development., The study was supported by the German Federal Ministry of Education and Research (BMBF), through the Integrated Network IntegraMent, under the auspices of the e:Med programme (grants 01ZX1314A to MMN and SC; 01ZX1314G to MR; 01ZX1614J to BMM) through grants 01EE1406C to MR and 01EE1409C to MR and SHW, and through ERA-NET NEURON, “SynSchiz—Linking synaptic dysfunction to disease mechanisms in schizophrenia—a multilevel investigation” (01EW1810 to MR) and BMBF grants 01EE1409C and 01EE1406C to MR and SHW; by the German Research Foundation (DFG grants FOR2107; RI908/11-2 to MR; NO246/10-2 to MMN; MU1315/8-2 to BMM; WI 3439/3-2 to SHW), by the Andalusian regional Health and Innovation Government (grants PI-0060-2017, RC-0006-2015 the Nicolas Monarde Programme for YDO and CTS-546) and by the Swiss National Science Foundation (SNSF grant 156791 to SC). MMN is a member of the DFG-funded cluster of excellence ImmunoSensation. The PGC has received major funding from the US National Institute of Mental Health and the US National Institute of Drug Abuse (U01 MH109528 and U01 MH1095320). We thank the research participants and employees of 23andMe, Inc. for their contribution to the MDD meta-analysis published in [14]. We thank the International Genomics of Alzheimer's Project (IGAP) for providing summary results data for the present analyses. See the Supplementary Data for extended Acknowledgements.
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- 2021
217. Interplay between the Genetics of Personality Traits, severe Psychiatric Disorders, and COVID-19 Host Genetics in the Susceptibility to SARS-CoV-2 Infection
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Heilbronner, Urs, primary, Streit, Fabian, additional, Vogl, Thomas, additional, Senner, Fanny, additional, Schaupp, Sabrina K., additional, Reich-Erkelenz, Daniela, additional, Papiol, Sergi, additional, Kohshour, Mojtaba Oraki, additional, Klöhn-Saghatolislam, Farahnaz, additional, Kalman, Janos L., additional, Heilbronner, Maria, additional, Gade, Katrin, additional, Comes, Ashley L., additional, Budde, Monika, additional, Andlauer, Till F. M., additional, Anderson-Schmidt, Heike, additional, Adorjan, Kristina, additional, Stürmer, Til, additional, Loerbroks, Adrian, additional, Amelang, Manfred, additional, Poisel, Eric, additional, Foo, Jerome, additional, Heilmann-Heimbach, Stefanie, additional, Forstner, Andreas J., additional, Degenhardt, Franziska, additional, Zimmermann, Jörg, additional, Wiltfang, Jens, additional, von Hagen, Martin, additional, Spitzer, Carsten, additional, Schmauss, Max, additional, Reininghaus, Eva, additional, Reimer, Jens, additional, Konrad, Carsten, additional, Juckel, Georg, additional, Lang, Fabian U., additional, Jäger, Markus, additional, Figge, Christian, additional, Fallgatter, Andreas J., additional, Dietrich, Detlef E., additional, Dannlowski, Udo, additional, Baune, Bernhardt T., additional, Arolt, Volker, additional, Anghelescu, Ion-George, additional, Nöthen, Markus M., additional, Witt, Stephanie H., additional, Andreassen, Ole A., additional, Chen, Chi-Hua, additional, Falkai, Peter, additional, Rietschel, Marcella, additional, Schulze, Thomas G., additional, and Schulte, Eva C., additional
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- 2021
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218. F86. INTEGRATIVE ANALYSIS OF MICRORNA EXPRESSION PROFILES REVEALS POTENTIAL MOLECULAR MECHANISMS UNDERLYING BROAD DIAGNOSTIC GROUPS
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Poschmann, Jeremie, Solomon, Pierre, Heilbronner, Urs, Budde, Monika, Kaurani, Lalit, Guiné, Jean-Baptiste, Fischer, André, and Schulze, Thomas
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- 2023
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219. Effects of Endurance Training Combined With Cognitive Remediation on Everyday Functioning, Symptoms, and Cognition in Multiepisode Schizophrenia Patients
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Malchow, Berend, Keller, Katriona, Hasan, Alkomiet, Dörfler, Sebastian, Schneider-Axmann, Thomas, Hillmer-Vogel, Ursula, Honer, William G., Schulze, Thomas G., Niklas, Andree, Wobrock, Thomas, Schmitt, Andrea, and Falkai, Peter
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- 2015
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220. Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion
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Wüst, Stefan, Kumsta, Robert, Treutlein, Jens, Frank, Josef, Entringer, Sonja, Schulze, Thomas G., and Rietschel, Marcella
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- 2009
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221. Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 ( GRID1) gene promoter
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Treutlein, Jens, Mühleisen, Thomas W., Frank, Josef, Mattheisen, Manuel, Herms, Stefan, Ludwig, Kerstin U., Treutlein, Tsendsesmee, Schmael, Christine, Strohmaier, Jana, Böβhenz, Katja Veronika, Breuer, René, Paul, Torsten, Witt, Stephanie H., Schulze, Thomas G., Schlösser, Ralf G.M., Nenadic, Igor, Sauer, Heinrich, Becker, Tim, Maier, Wolfgang, Cichon, Sven, Nöthen, Markus M., and Rietschel, Marcella
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- 2009
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222. Premorbid adjustment: A phenotype highlighting a distinction rather than an overlap between schizophrenia and bipolar disorder
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Rietschel, Marcella, Georgi, Alexander, Schmael, Christine, Schirmbeck, Frederike, Strohmaier, Jana, Boesshenz, Katja V., Schwarz, Markus, Nöthen, Markus M., and Schulze, Thomas G.
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- 2009
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223. The Genetics of Response to and Side Effects of Lithium Treatment in Bipolar Disorder: Future Research Perspectives
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Senner, Fanny, Kohshour, Mojtaba Oraki, Abdalla, Safa, Papiol, Sergi, and Schulze, Thomas G.
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Pharmacology ,bipolar disorder ,candidate-gene association studies ,side effect ,lithium ,linkage and segregation studies ,GWAS ,treatment response ,Pharmacology (medical) ,Review ,pharmacogenetics - Abstract
Although the mood stabilizer lithium is a first-line treatment in bipolar disorder, a substantial number of patients do not benefit from it and experience side effects. No clinical tool is available for predicting lithium response or the occurrence of side effects in everyday clinical practice. Multiple genetic research efforts have been performed in this field because lithium response and side effects are considered to be multifactorial endophenotypes. Available results from linkage and segregation, candidate-gene, and genome-wide association studies indicate a role of genetic factors in determining response and side effects. For example, candidate-gene studies often report GSK3β, brain-derived neurotrophic factor, and SLC6A4 as being involved in lithium response, and the latest genome-wide association study found a genome-wide significant association of treatment response with a locus on chromosome 21 coding for two long non-coding RNAs. Although research results are promising, they are limited mainly by a lack of replicability and, despite the collaboration of consortia, insufficient sample sizes. The need for larger sample sizes and "multi-omics" approaches is apparent, and such approaches are crucial for choosing the best treatment options for patients with bipolar disorder. In this article, we delineate the mechanisms of action of lithium and summarize the results of genetic research on lithium response and side effects.
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- 2021
224. Association of ADHD and depression polygenic scores with lithium response: A Consortium for Lithium Genetics study
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Coombes, Brandon J, Millischer, Vincent, Amare, Azmeraw T, Vieta, Eduard, Witt, Stephanie H, Zandi, Peter P, Fullerton, Janice M, Alda, Martin, Frye, Mark A, Schulze, Thomas G, McMahon, Francis J, Biernacka, Joanna M, Ardau, Raffaella, Arias, Barbara, Aubry, Jean-Michel, Backlund, Lena, Bauer, Michael, Baune, Bernhard T, Bellivier, Frank, Benabarre, Antoni, Bengesser, Susanne, Batzler, Anthony, Bhattacharjee, Abesh Kumar, Cervantes, Pablo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Clark, Scott R, Colom, Francesc, Cruceanu, Cristiana, Czerski, Piotr M, Dalkner, Nina, Larrabee, Beth, Degenhardt, Franziska, Zompo, Maria Del, DePaulo, J Raymond, Étain, Bruno, Falkai, Peter, Ferensztajn-Rochowiak, Ewa, Forstner, Andreas J, Frisen, Louise, Gard, Sébastien, Garnham, Julie S, Hou, Liping, Goes, Fernando S, Grigoroiu-Serbanescu, Maria, Grof, Paul, Hashimoto, Ryota, Hauser, Joanna, Herms, Stefan, Hoffmann, Per, Jamain, Stephane, Jiménez, Esther, Kahn, Jean-Pierre, Papiol, Sergi, Kassem, Layla, Kato, Tadafumi, Kelsoe, John R, Kittel-Schneider, Sarah, König, Barbara, Kuo, Po-Hsiu, Kusumi, Ichiro, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Heilbronner, Urs, Leboyer, Marion, Leckband, Susan G, Maj, Mario, Manchia, Mirko, Martinsson, Lina, McCarthy, Michael J, McElroy, Susan L, Mitchell, Philip B, Mitjans, Marina, Mondimore, Francis M, Adli, Mazda, Monteleone, Palmiero, Nievergelt, Caroline M, Nöthen, Markus M, Novák, Tomas, O'Donovan, Claire, Osby, Urban, Ozaki, Norio, Pfennig, Andrea, Pisanu, Claudia, Potash, James B, Akiyama, Kazufumi, Reif, Andreas, Reininghaus, Eva, Rietschel, Marcella, Rouleau, Guy A, Rybakowski, Janusz K, Schalling, Martin, Schofield, Peter R, Schubert, Klaus Oliver, Schweizer, Barbara W, Severino, Giovanni, Akula, Nirmala, Shekhtman, Tatyana, Shilling, Paul D, Shimoda, Katzutaka, Simhandl, Christian, Slaney, Claire M, Squassina, Alessio, Stamm, Thomas, Stopkova, Pavla, Tortorella, Alfonso, and Turecki, Gustavo
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ddc:150 - Published
- 2021
225. Characterisation of age and polarity at onset in bipolar disorder
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Kalman, Janos, Olde Loohuis, Loes, Vreeker, Annabel, Mcquillin, Andrew, Stahl, Eli, Ruderfer, Douglas, Grigoroiu-Serbanescu, Maria, Panagiotaropoulou, Georgia, Ripke, Stephan, Bigdeli, Tim, Stein, Frederike, Meller, Tina, Meinert, Susanne, Pelin, Helena, Streit, Fabian, Papiol, Sergi, Adams, Mark, Adolfsson, Rolf, Adorjan, Kristina, Agartz, Ingrid, Aminoff, Sofie, Anderson-Schmidt, Heike, Andreassen, Ole, Ardau, Raffaella, Aubry, Jean-Michel, Balaban, Ceylan, Bass, Nicholas, Baune, Bernhard, Bellivier, Frank, Benabarre, Antoni, Bengesser, Susanne, Berrettini, Wade, Boks, Marco, Bromet, Evelyn, Brosch, Katharina, Budde, Monika, Byerley, William, Cervantes, Pablo, Chillotti, Catina, Cichon, Sven, Clark, Scott, Comes, Ashley, Corvin, Aiden, Coryell, William, Craddock, Nick, Craig, David, Croarkin, Paul, Cruceanu, Cristiana, Czerski, Piotr, Dalkner, Nina, Dannlowski, Udo, Degenhardt, Franziska, del Zompo, Maria, Depaulo, J Raymond, Djurovic, Srdjan, Edenberg, Howard, Eissa, Mariam Al, Elvsåshagen, Torbjørn, Etain, Bruno, Fanous, Ayman, Fellendorf, Frederike, Fiorentino, Alessia, Forstner, Andreas, Frye, Mark, Fullerton, Janice, Gade, Katrin, Garnham, Julie, Gershon, Elliot, Gill, Michael, Goes, Fernando, Gordon-Smith, Katherine, Grof, Paul, Guzman-Parra, Jose, Hahn, Tim, Hasler, Roland, Heilbronner, Maria, Heilbronner, Urs, Jamain, Stephane, Jimenez, Esther, Jones, Ian, Jones, Lisa, Jonsson, Lina, Kahn, Rene, Kelsoe, John, Kennedy, James, Kircher, Tilo, Kirov, George, Kittel-Schneider, Sarah, Klöhn-Saghatolislam, Farah, Knowles, James, Kranz, Thorsten, Lagerberg, Trine Vik, Landen, Mikael, Lawson, William, Leboyer, Marion, Li, Qingqin, Maj, Mario, Malaspina, Dolores, Manchia, Mirko, Mayoral, Fermin, Mcelroy, Susan, Mcinnis, Melvin, McIntosh, Andrew, Medeiros, Helena, Melle, Ingrid, Milanova, Vihra, Mitchell, Philip, Monteleone, Palmiero, Monteleone, Alessio Maria, Nöthen, Markus, Novak, Tomas, Nurnberger, John, O'Brien, Niamh, O'Connell, Kevin, O'Donovan, Claire, O'Donovan, Michael, Opel, Nils, Ortiz, Abigail, Owen, Michael, Pålsson, Erik, Pato, Carlos, Pato, Michele, Pawlak, Joanna, Pfarr, Julia-Katharina, Pisanu, Claudia, Potash, James, Rapaport, Mark, Reich-Erkelenz, Daniela, Reif, Andreas, Reininghaus, Eva, Repple, Jonathan, Richard-Lepouriel, Hélène, Rietschel, Marcella, Ringwald, Kai, Roberts, Gloria, Rouleau, Guy, Schaupp, Sabrina, Scheftner, William, Schmitt, Simon, Schofield, Peter, Schubert, K Oliver, Schulte, Eva, Schweizer, Barbara, Senner, Fanny, Severino, Giovanni, Sharp, Sally, Slaney, Claire, Smeland, Olav, Sobell, Janet, Squassina, Alessio, Stopkova, Pavla, Strauss, John, Tortorella, Alfonso, Turecki, Gustavo, Twarowska-Hauser, Joanna, Veldic, Marin, Vieta, Eduard, Vincent, John, Xu, Wei, Zai, Clement, Zandi, Peter, Di Florio, Arianna, Smoller, Jordan, Biernacka, Joanna, Mcmahon, Francis, Alda, Martin, Müller-Myhsok, Bertram, Koutsouleris, Nikolaos, Falkai, Peter, Freimer, Nelson, Andlauer, Till, Schulze, Thomas, Ophoff, Roel, Depaulo, J. Raymond, Schubert, K. Oliver, Andlauer, Till F.M., Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), IMRB - 'Neuropsychiatrie translationnelle' [Créteil] (U955 Inserm - UPEC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Etain, Bruno, Child and Adolescent Psychiatry / Psychology, Psychiatry, Kalman, J. L., Loohuis, L. M. O., Vreeker, A., Mcquillin, A., Stahl, E. A., Ruderfer, D., Grigoroiu-Serbanescu, M., Panagiotaropoulou, G., Ripke, S., Bigdeli, T. B., Stein, F., Meller, T., Meinert, S., Pelin, H., Streit, F., Papiol, S., Adams, M. J., Adolfsson, R., Adorjan, K., Agartz, I., Aminoff, S. R., Anderson-Schmidt, H., Andreassen, O. A., Ardau, R., Aubry, J. -M., Balaban, C., Bass, N., Baune, B. T., Bellivier, F., Benabarre, A., Bengesser, S., Berrettini, W. H., Boks, M. P., Bromet, E. J., Brosch, K., Budde, M., Byerley, W., Cervantes, P., Chillotti, C., Cichon, S., Clark, S. R., Comes, A. L., Corvin, A., Coryell, W., Craddock, N., Craig, D. W., Croarkin, P. E., Cruceanu, C., Czerski, P. M., Dalkner, N., Dannlowski, U., Degenhardt, F., Del Zompo, M., Depaulo, J. R., Djurovic, S., Edenberg, H. J., Al Eissa, M., Elvsashagen, T., Etain, B., Fanous, A. H., Fellendorf, F., Fiorentino, A., Forstner, A. J., Frye, M. A., Fullerton, J. M., Gade, K., Garnham, J., Gershon, E., Gill, M., Goes, F. S., Gordon-Smith, K., Grof, P., Guzman-Parra, J., Hahn, T., Hasler, R., Heilbronner, M., Heilbronner, U., Jamain, S., Jimenez, E., Jones, I., Jones, L., Jonsson, L., Kahn, R. S., Kelsoe, J. R., Kennedy, J. L., Kircher, T., Kirov, G., Kittel-Schneider, S., Klohn-Saghatolislam, F., Knowles, J. A., Kranz, T. M., Lagerberg, T. V., Landen, M., Lawson, W. B., Leboyer, M., Li, Q. S., Maj, M., Malaspina, D., Manchia, M., Mayoral, F., Mcelroy, S. L., Mcinnis, M. G., Mcintosh, A. M., Medeiros, H., Melle, I., Milanova, V., Mitchell, P. B., Monteleone, P., Monteleone, A. M., Nothen, M. M., Novak, T., Nurnberger, J. I., O'Brien, N., O'Connell, K. S., O'Donovan, C., O'Donovan, M. C., Opel, N., Ortiz, A., Owen, M. J., Palsson, E., Pato, C., Pato, M. T., Pawlak, J., Pfarr, J. -K., Pisanu, C., Potash, J. B., Rapaport, M. H., Reich-Erkelenz, D., Reif, A., Reininghaus, E., Repple, J., Richard-Lepouriel, H., Rietschel, M., Ringwald, K., Roberts, G., Rouleau, G., Schaupp, S., Scheftner, W. A., Schmitt, S., Schofield, P. R., Schubert, K. O., Schulte, E. C., Schweizer, B., Senner, F., Severino, G., Sharp, S., Slaney, C., Smeland, O. B., Sobell, J. L., Squassina, A., Stopkova, P., Strauss, J., Tortorella, A., Turecki, G., Twarowska-Hauser, J., Veldic, M., Vieta, E., Vincent, J. B., Xu, W., Zai, C. C., Zandi, P. P., Di Florio, A., Smoller, J. W., Biernacka, J. M., Mcmahon, F. J., Alda, M., Muller-Myhsok, B., Koutsouleris, N., Falkai, P., Freimer, N. B., Andlauer, T. F. M., Schulze, T. G., and Ophoff, R. A.
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Paper ,Multifactorial Inheritance ,medicine.medical_specialty ,Autism Spectrum Disorder ,Bipolar disorder ,MESH: Age of Onset ,[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Medizin ,GWAS ,age at onset ,polarity at onset ,polygenic score ,MESH: Depressive Disorder, Major ,BF ,Genome-wide association study ,Disease ,Psykiatri ,SDG 3 - Good Health and Well-being ,ddc:150 ,Polarity at onset ,Internal medicine ,MESH: Bipolar Disorder ,Polygenic score ,medicine ,Humans ,Academic Psychiatry ,Age of Onset ,Genetic association ,Psychiatry ,MESH: Autism Spectrum Disorder ,Depressive Disorder, Major ,MESH: Humans ,business.industry ,Age at onset ,Heritability ,medicine.disease ,Genetic architecture ,ddc ,Psychiatry and Mental health ,Schizophrenia ,Autism spectrum disorder ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,MESH: Genome-Wide Association Study ,RC0321 ,MESH: Multifactorial Inheritance ,business ,Genome-Wide Association Study - Abstract
BackgroundStudying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.AimsTo examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.MethodGenome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.ResultsEarlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.ConclusionsAAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
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- 2021
226. Increased afterload induces pathological cardiac hypertrophy: a new in vitro model
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Hirt, Marc N., Sörensen, Nils A., Bartholdt, Lena M., Boeddinghaus, Jasper, Schaaf, Sebastian, Eder, Alexandra, Vollert, Ingra, Stöhr, Andrea, Schulze, Thomas, Witten, Anika, Stoll, Monika, Hansen, Arne, and Eschenhagen, Thomas
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- 2012
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227. Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation
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Cuello, Friederike, primary, Knaust, Anika E, additional, Saleem, Umber, additional, Loos, Malte, additional, Raabe, Janice, additional, Mosqueira, Diogo, additional, Laufer, Sandra, additional, Schweizer, Michaela, additional, Kraak, Petra, additional, Flenner, Frederik, additional, Ulmer, Bärbel M, additional, Braren, Ingke, additional, Yin, Xiaoke, additional, Theofilatos, Konstantinos, additional, Ruiz‐Orera, Jorge, additional, Patone, Giannino, additional, Klampe, Birgit, additional, Schulze, Thomas, additional, Piasecki, Angelika, additional, Pinto, Yigal, additional, Vink, Aryan, additional, Hübner, Norbert, additional, Harding, Sian, additional, Mayr, Manuel, additional, Denning, Chris, additional, Eschenhagen, Thomas, additional, and Hansen, Arne, additional
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- 2021
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228. Contribution of Rare Variants to Bipolar Disorder Susceptibility
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Forstner, Andreas J., primary, Karhoff, Katharina, additional, Maaser-Hecker, Anna, additional, Streit, Fabian, additional, Sivalingam, Sugirthan, additional, Ludwig, Kerstin U., additional, Degenhardt, Franziska, additional, Herms, Stefan, additional, Hoffmann, Per, additional, Witt, Stephanie H., additional, Maier, Wolfgang, additional, Schulze, Thomas G., additional, Albus, Margot, additional, Borrmann-Hassenbach, Margitta, additional, Bauer, Michael, additional, Reif, Andreas, additional, Moebus, Susanne, additional, Dannlowski, Udo, additional, Kircher, Tilo, additional, Cichon, Sven, additional, Rietschel, Marcella, additional, and Nöthen, Markus M., additional
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- 2021
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229. Association Between Physical Activity and Schizophrenia
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Papiol, Sergi, primary, Schmitt, Andrea, additional, Maurus, Isabel, additional, Rossner, Moritz J., additional, Schulze, Thomas G., additional, and Falkai, Peter, additional
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- 2021
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230. Being a strong voice for mental health parity, human rights, and community‐based psychiatric care in challenging times: developing the WPAAction Plan 2026‐2029
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Schulze, Thomas G.
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- 2024
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231. A genome-wide association study of the longitudinal course of executive functions
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Wendel, Bernadette, Papiol, Sergi, Repple, Jonathan, Reininghaus, Eva, Reimer, Jens, Reich-Erkelenz, Daniela, Opel, Nils, Nenadić, Igor, Meinert, Susanne, Konrad, Carsten, Klöhn-Saghatolislam, Farahnaz, Kircher, Tilo, Andlauer, Till F M, Kalman, Janos L, Juckel, Georg, Jansen, Andreas, Jäger, Markus, Heilbronner, Maria, von Hagen, Martin, Gade, Katrin, Figge, Christian, Fallgatter, Andreas, Dietrich, Detlef E, Zimmermann, Jörg, Dannlowski, Udo, Comes, Ashley L, Budde, Monika, Baune, Bernhard T, Arolt, Volker, Anghelescu, Ion-George, Anderson-Schmidt, Heike, Adorjan, Kristina, Falkai, Peter, Schulze, Thomas G, Wiltfang, Jens, Bickeböller, Heike, Heilbronner, Urs, Spitzer, Carsten, Senner, Fanny, Schulte, Eva C, Schmauß, Max, and Schaupp, Sabrina K
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Executive Function ,Genotype ,Humans ,Psychology ,Neurosciences. Biological psychiatry. Neuropsychiatry ,ddc:610 ,Genomics ,Polymorphism, Single Nucleotide ,Linkage Disequilibrium ,Article ,RC321-571 ,Genome-Wide Association Study - Abstract
Executive functions are metacognitive capabilities that control and coordinate mental processes. In the transdiagnostic PsyCourse Study, comprising patients of the affective-to-psychotic spectrum and controls, we investigated the genetic basis of the time course of two core executive subfunctions: set-shifting (Trail Making Test, part B (TMT-B)) and updating (Verbal Digit Span backwards) in 1338 genotyped individuals. Time course was assessed with four measurement points, each 6 months apart. Compared to the initial assessment, executive performance improved across diagnostic groups. We performed a genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with performance change over time by testing for SNP-by-time interactions using linear mixed models. We identified nine genome-wide significant SNPs for TMT-B in strong linkage disequilibrium with each other on chromosome 5. These were associated with decreased performance on the continuous TMT-B score across time. Variant rs150547358 had the lowest P value = 7.2 × 10−10 with effect estimate beta = 1.16 (95% c.i.: 1.11, 1.22). Implementing data of the FOR2107 consortium (1795 individuals), we replicated these findings for the SNP rs150547358 (P value = 0.015), analyzing the difference of the two available measurement points two years apart. In the replication study, rs150547358 exhibited a similar effect estimate beta = 0.85 (95% c.i.: 0.74, 0.97). Our study demonstrates that longitudinally measured phenotypes have the potential to unmask novel associations, adding time as a dimension to the effects of genomics.
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- 2020
232. A novel longitudinal clustering approach to psychopathology across diagnostic entities in the hospital-based PsyCourse study
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Schulte, Eva C, Kondofersky, Ivan, Hake, Maria, Comes, Ashley L, Anderson-Schmidt, Heike, Adorjan, Kristina, Juckel, Georg, Schmauß, Max, Zimmermann, Jörg, Reimer, Jens, Wiltfang, Jens, Reininghaus, Eva Z, Budde, Monika, Anghelescu, Ion-George, Konrad, Carsten, Figge, Christian, von Hagen, Martin, Jäger, Markus, Dietrich, Detlef E, Spitzer, Carsten, Witt, Stephanie H, Forstner, Andreas J, Rietschel, Marcella, Papiol, Sergi, Nöthen, Markus M., Falkai, Peter, Heilbronner, Urs, Mueller, Nikola S, Schulze, Thomas G, Senner, Fanny, Schaupp, Sabrina K, Reich-Erkelenz, Daniela, Klöhn-Saghatolislam, Farahnaz, Kalman, Janos L, and Gade, Katrin
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Bipolar Disorder ,Psychopathology ,Bipolar disorder ,Mental Disorders ,diagnosis [Mental Disorders] ,epidemiology [Mental Disorders] ,Hospitals ,Psychiatry and Mental health ,Cluster analysis ,epidemiology [Bipolar Disorder] ,Machine learning ,Schizophrenia ,Cluster Analysis ,Humans ,ddc:610 ,diagnosis [Bipolar Disorder] ,psychology [Bipolar Disorder] ,Biological Psychiatry - Abstract
Biological research and clinical management in psychiatry face two major impediments: the high degree of overlap in psychopathology between diagnoses and the inherent heterogeneity with regard to severity. Here, we aim to stratify cases into homogeneous transdiagnostic subgroups using psychometric information with the ultimate aim of identifying individuals with higher risk for severe illness. 397 participants of the PsyCourse study with schizophrenia- or bipolar-spectrum diagnoses were prospectively phenotyped over 18 months. Factor analysis of mixed data of different rating scales and subsequent longitudinal clustering were used to cluster disease trajectories. Five clusters of longitudinal trajectories were identified in the psychopathologic dimensions. Clusters differed significantly with regard to Global Assessment of Functioning, disease course, and-in some cases-diagnosis while there were no significant differences regarding sex, age at baseline or onset, duration of illness, or polygenic burden for schizophrenia. Longitudinal clustering may aid in identifying transdiagnostic homogeneous subgroups of individuals with severe psychiatric disease.
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- 2020
233. Risk stratification for bipolar disorder using polygenic risk scores among young high-risk adults
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Biere, Silvia, Kranz, Thorsten M., Matura, Silke, Petrova, Kristiyana, Streit, Fabian, Chiocchetti, Andreas G., Grimm, Oliver, Brum, Murielle, Brunkhorst-Kanaan, Natalie, Oertel, Viola, Malyshau, Aliaksandr, Pfennig, Andrea, Bauer, Michael, Schulze, Thomas G., Kittel-Schneider, Sarah, and Reif, Andreas
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ddc:150 ,ddc:610 - Abstract
Objective: Identifying high-risk groups with an increased genetic liability for bipolar disorder (BD) will provide insights into the etiology of BD and contribute to early detection of BD. We used the BD polygenic risk score (PRS) derived from BD genome-wide association studies (GWAS) to explore how such genetic risk manifests in young, high-risk adults. We postulated that BD-PRS would be associated with risk factors for BD. Methods: A final sample of 185 young, high-risk German adults (aged 18–35 years) were grouped into three risk groups and compared to a healthy control group (n = 1,100). The risk groups comprised 117 cases with attention deficit hyperactivity disorder (ADHD), 45 with major depressive disorder (MDD), and 23 help-seeking adults with early recognition symptoms [ER: positive family history for BD, (sub)threshold affective symptomatology and/or mood swings, sleeping disorder]. BD-PRS was computed for each participant. Logistic regression models (controlling for sex, age, and the first five ancestry principal components) were used to assess associations of BD-PRS and the high-risk phenotypes. Results: We observed an association between BD-PRS and combined risk group status (OR = 1.48, p < 0.001), ADHD diagnosis (OR = 1.32, p = 0.009), MDD diagnosis (OR = 1.96, p < 0.001), and ER group status (OR = 1.7, p = 0.025; not significant after correction for multiple testing) compared to healthy controls. Conclusions: In the present study, increased genetic risk for BD was a significant predictor for MDD and ADHD status, but not for ER. These findings support an underlying shared risk for both MDD and BD as well as ADHD and BD. Improving our understanding of the underlying genetic architecture of these phenotypes may aid in early identification and risk stratification.
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- 2020
234. The hippocampus in families with schizophrenia in relation to obstetric complications
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Ebner, Florian, Tepest, Ralf, Dani, Indra, Pfeiffer, Ute, Schulze, Thomas G., Rietschel, Marcella, Maier, Wolfgang, Träber, Frank, Block, Wolfgang, Schild, Hans H., Wagner, Michael, Steinmetz, Helmuth, Gaebel, Wolfgang, Honer, William G., Schneider-Axmann, Thomas, and Falkai, Peter
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- 2008
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235. High-resolution 3D non-contrast-enhanced, ECG-gated, multi-step MR angiography of the lower extremities: Comparison with contrast-enhanced MR angiography
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Mohrs, Oliver K., Petersen, Steffen E., Heidt, Martin C., Schulze, Thomas, Schmitt, Peter, Bergemann, Sabine, and Kauczor, Hans-Ulrich
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- 2011
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236. How the green alga Chlamydomonas reinhardtii keeps time
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Schulze, Thomas, Prager, Katja, Dathe, Hannes, Kelm, Juliane, Kießling, Peter, and Mittag, Maria
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- 2010
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237. Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia
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Schmitt, Andrea, Koschel, Jiri, Zink, Mathias, Bauer, Manfred, Sommer, Clemens, Frank, Josef, Treutlein, Jens, Schulze, Thomas, Schneider-Axmann, Thomas, Parlapani, Eleni, Rietschel, Marcella, Falkai, Peter, and Henn, Fritz A.
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- 2010
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238. Molecular actions and clinical pharmacogenetics of lithium therapy
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Can, Adem, Schulze, Thomas G., and Gould, Todd D.
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- 2014
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239. Need exists for genetic predictors of lithium response
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Potash, James B and Schulze, Thomas G
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- 2014
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240. Biological insights from 108 schizophrenia-associated genetic loci
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Ripke, Stephan, Neale, Benjamin M., Corvin, Aiden, Walters, James T. R., Farh, Kai-How, Holmans, Peter A., Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Jr, Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Byerley, William, Cahn, Wiepke, Cai, Guiqing, Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa, Catts, Stanley V., Chambert, Kimberly D., Chan, Raymond C. K., Chen, Ronald Y. L., Chen, Eric Y. H., Cheng, Wei, Cheung, Eric F. C., Chong, Siow Ann, Cloninger, Robert C., Cohen, David, Cohen, Nadine, Cormican, Paul, Craddock, Nick, Crowley, James J., Curtis, David, Davidson, Michael, Davis, Kenneth L., Degenhardt, Franziska, Del Favero, Jurgen, Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Dudbridge, Frank, Durmishi, Naser, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Fanous, Ayman H., Farrell, Martilias S., Frank, Josef, Franke, Lude, Freedman, Robert, Freimer, Nelson B., Friedl, Marion, Friedman, Joseph I., Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., Golimbet, Vera, Gopal, Srihari, Gratten, Jacob, de Haan, Lieuwe, Hammer, Christian, Hamshere, Marian L., Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M., Henskens, Frans A., Herms, Stefan, Hirschhorn, Joel N., Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V., Hougaard, David M., Ikeda, Masashi, Joa, Inge, Julià, Antonio, Kahn, René S., Kalaydjieva, Luba, Karachanak-Yankova, Sena, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C., Kennedy, James L., Khrunin, Andrey, Kim, Yunjung, Klovins, Janis, Knowles, James A., Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova-Ptackova, Hana, Kähler, Anna K., Laurent, Claudine, Lee Chee Keong, Jimmy, Lee, Hong S., Legge, Sophie E., Lerer, Bernard, Li, Miaoxin, Li, Tao, Liang, Kung-Yee, Lieberman, Jeffrey, Limborska, Svetlana, Loughland, Carmel M., Lubinski, Jan, Lönnqvist, Jouko, Macek, Milan, Jr, Magnusson, Patrik K. E., Maher, Brion S., Maier, Wolfgang, Mallet, Jacques, Marsal, Sara, Mattheisen, Manuel, Mattingsdal, Morten, McCarley, Robert W., McDonald, Colm, McIntosh, Andrew M., Meier, Sandra, Meijer, Carin J., Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mokrab, Younes, Morris, Derek W., Mors, Ole, Murphy, Kieran C., Murray, Robin M., Myin-Germeys, Inez, Müller-Myhsok, Bertram, Nelis, Mari, Nenadic, Igor, Nertney, Deborah A., Nestadt, Gerald, Nicodemus, Kristin K., Nikitina-Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, OʼCallaghan, Eadbhard, OʼDushlaine, Colm, OʼNeill, Anthony F., Oh, Sang-Yun, Olincy, Ann, Olsen, Line, Van Os, Jim, Pantelis, Christos, Papadimitriou, George N., Papiol, Sergi, Parkhomenko, Elena, Pato, Michele T., Paunio, Tiina, Pejovic-Milovancevic, Milica, Perkins, Diana O., Pietiläinen, Olli, Pimm, Jonathan, Pocklington, Andrew J., Powell, John, Price, Alkes, Pulver, Ann E., Purcell, Shaun M., Quested, Digby, Rasmussen, Henrik B., Reichenberg, Abraham, Reimers, Mark A., Richards, Alexander L., Roffman, Joshua L., Roussos, Panos, Ruderfer, Douglas M., Salomaa, Veikko, Sanders, Alan R., Schall, Ulrich, Schubert, Christian R., Schulze, Thomas G., Schwab, Sibylle G., Scolnick, Edward M., Scott, Rodney J., Seidman, Larry J., Shi, Jianxin, Sigurdsson, Engilbert, Silagadze, Teimuraz, Silverman, Jeremy M., Sim, Kang, Slominsky, Petr, Smoller, Jordan W., So, Hon-Cheong, Spencer, ChrisC. A., Stahl, Eli A., Stefansson, Hreinn, Steinberg, Stacy, Stogmann, Elisabeth, Straub, Richard E., Strengman, Eric, Strohmaier, Jana, Stroup, Scott T., Subramaniam, Mythily, Suvisaari, Jaana, Svrakic, Dragan M., Szatkiewicz, Jin P., Söderman, Erik, Thirumalai, Srinivas, Toncheva, Draga, Tosato, Sarah, Veijola, Juha, Waddington, John, Walsh, Dermot, Wang, Dai, Wang, Qiang, Webb, Bradley T., Weiser, Mark, Wildenauer, Dieter B., Williams, Nigel M., Williams, Stephanie, Witt, Stephanie H., Wolen, Aaron R., Wong, Emily H. M., Wormley, Brandon K., Xi, Hualin Simon, Zai, Clement C., Zheng, Xuebin, Zimprich, Fritz, Wray, Naomi R., Stefansson, Kari, Visscher, Peter M., Adolfsson, Rolf, Andreassen, Ole A., Blackwood, Douglas H. R., Bramon, Elvira, Buxbaum, Joseph D., Børglum, Anders D., Cichon, Sven, Darvasi, Ariel, Domenici, Enrico, Ehrenreich, Hannelore, Esko, Tõnu, Gejman, Pablo V., Gill, Michael, Gurling, Hugh, Hultman, Christina M., Iwata, Nakao, Jablensky, Assen V., Jönsson, Erik G., Kendler, Kenneth S., Kirov, George, Knight, Jo, Lencz, Todd, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., McCarroll, Steven A., McQuillin, Andrew, Moran, Jennifer L., Mortensen, Preben B., Mowry, Bryan J., Nöthen, Markus M., Ophoff, Roel A., Owen, Michael J., Palotie, Aarno, Pato, Carlos N., Petryshen, Tracey L., Posthuma, Danielle, Rietschel, Marcella, Riley, Brien P., Rujescu, Dan, Sham, Pak C., Sklar, Pamela, St Clair, David, Weinberger, Daniel R., Wendland, Jens R., Werge, Thomas, Daly, Mark J., Sullivan, Patrick F., and OʼDonovan, Michael C.
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- 2014
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241. Genetic predictors of response to antidepressants in the GENDEP project
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Uher, Rudolf, Huezo-Diaz, Patricia, Perroud, Nader, Smith, Rebecca, Rietschel, Marcella, Mors, Ole, Hauser, Joanna, Maier, Wolfgang, Kozel, Dejan, Henigsberg, Neven, Barreto, Mara, Placentino, Anna, Dernovsek, Mojca Zvezdana, Schulze, Thomas G, Kalember, Petra, Zobel, Astrid, Czerski, Piotr M, Larsen, Erik Roj, Souery, Daniel, Giovannini, Caterina, Gray, Joanna M, Lewis, Cathryn M, Farmer, Anne, Aitchison, Katherine J, McGuffin, Peter, and Craig, Ian
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- 2009
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242. Induction and quantification of prefrontal cortical network plasticity using 5 Hz rTMS and fMRI
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Esslinger, Christine, Schüler, Nadja, Sauer, Carina, Gass, Dagmar, Mier, Daniela, Braun, Urs, Ochs, Elisabeth, Schulze, Thomas G., Rietschel, Marcella, Kirsch, Peter, and Meyer-Lindenberg, Andreas
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- 2014
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243. Brief Report: No Association Between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin
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Schirmbeck, Frederike, Georgi, Alexander, Strohmaier, Jana, Schmael, Christine, Boesshenz, Katja V., Mühleisen, Thomas W., Herms, Stefan, Hoffmann, Per, Jamra, Rami Abou, Schumacher, Johannes, Maier, Wolfgang, Propping, Peter, Nöthen, Markus M., Cichon, Sven, Rietschel, Marcella, and Schulze, Thomas G.
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- 2008
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244. First experiences with contrast-enhanced first-pass MR perfusion imaging in patients with primary, benign cardiac masses and tumour-like lesions
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Mohrs, Oliver K., Voigtlaender, Thomas, Petersen, Steffen E., Zander, Matthias, Schulze, Thomas, Pottmeyer, Anselm, and Kauczor, Hans-Ulrich
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- 2008
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245. Corrigendum to “Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action [European Neuropsychopharmacology (2020) 36, 121–136]”
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Manchia, Mirko, primary, Vieta, Eduard, additional, Smeland, Olav B., additional, Altimus, Cara, additional, Bechdolf, Andreas, additional, Bellivier, Frank, additional, Bergink, Veerle, additional, Fagiolini, Andrea, additional, Geddes, John R., additional, Hajek, Tomas, additional, Henry, Chantal, additional, Kupka, Ralph, additional, Lagerberg, Trine V., additional, Licht, Rasmus W., additional, Martinez-Cengotitabengoa, Monica, additional, Morken, Gunnar, additional, Nielsen, René E., additional, González-Pinto, Ana, additional, Reif, Andreas, additional, Rietschel, Marcella, additional, Ritter, Phillip, additional, Schulze, Thomas G., additional, Scott, Jan, additional, Severus, Emanuel, additional, Yildiz, Aysegul, additional, Kessing, Lars Vedel, additional, Bauer, Michael, additional, Goodwin, Guy M., additional, and Andreassen, Ole A., additional
- Published
- 2021
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246. In Vitro Selection Implicates ROP1 as a Resistance Gene for an Experimental Therapeutic Benzoquinone Acyl Hydrazone in Toxoplasma gondii
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Martens, Matthew C., primary, Won, Madalyn M., additional, Won, Harim I., additional, Schulze, Thomas T., additional, Judge, Abigail K., additional, Neville, Andrew J., additional, Vennerstrom, Jonathan L., additional, and Davis, Paul H., additional
- Published
- 2021
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247. “The Heidelberg Five” personality dimensions: Genome‐wide associations, polygenic risk for neuroticism, and psychopathology 20 years after assessment
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Heilbronner, Urs, primary, Papiol, Sergi, additional, Budde, Monika, additional, Andlauer, Till F. M., additional, Strohmaier, Jana, additional, Streit, Fabian, additional, Frank, Josef, additional, Degenhardt, Franziska, additional, Heilmann‐Heimbach, Stefanie, additional, Witt, Stephanie H., additional, Forstner, Andreas J., additional, Loerbroks, Adrian, additional, Amelang, Manfred, additional, Stürmer, Til, additional, Müller‐Myhsok, Bertram, additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, and Schulze, Thomas G., additional
- Published
- 2021
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248. Role of psychiatric hospitals during a pandemic: introducing the Munich Psychiatric COVID-19 Pandemic Contingency Plan
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Adorjan, Kristina, primary, Pogarell, Oliver, additional, Streb, Dorothee, additional, Padberg, Frank, additional, Erdmann, Christian, additional, Koller, Gabriele, additional, Raabe, Florian, additional, Reich-Erkelenz, Daniela, additional, de Jonge, Sylvia, additional, Neumeier, Karin, additional, Zill, Peter, additional, Jauch, Karl-Walter, additional, Schulze, Thomas G., additional, and Falkai, Peter, additional
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- 2021
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249. Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study
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Coombes, Brandon J., primary, Millischer, Vincent, additional, Batzler, Anthony, additional, Larrabee, Beth, additional, Hou, Liping, additional, Papiol, Sergi, additional, Heilbronner, Urs, additional, Adli, Mazda, additional, Akiyama, Kazufumi, additional, Akula, Nirmala, additional, Amare, Azmeraw T., additional, Ardau, Raffaella, additional, Arias, Barbara, additional, Aubry, Jean-Michel, additional, Backlund, Lena, additional, Bauer, Michael, additional, Baune, Bernhard T., additional, Bellivier, Frank, additional, Benabarre, Antoni, additional, Bengesser, Susanne, additional, Bhattacharjee, Abesh Kumar, additional, Cervantes, Pablo, additional, Chen, Hsi-Chung, additional, Chillotti, Caterina, additional, Cichon, Sven, additional, Clark, Scott R., additional, Colom, Francesc, additional, Cruceanu, Cristiana, additional, Czerski, Piotr M., additional, Dalkner, Nina, additional, Degenhardt, Franziska, additional, Del Zompo, Maria, additional, DePaulo, J. Raymond, additional, Étain, Bruno, additional, Falkai, Peter, additional, Ferensztajn-Rochowiak, Ewa, additional, Forstner, Andreas J., additional, Frisen, Louise, additional, Gard, Sébastien, additional, Garnham, Julie S., additional, Goes, Fernando S., additional, Grigoroiu-Serbanescu, Maria, additional, Grof, Paul, additional, Hashimoto, Ryota, additional, Hauser, Joanna, additional, Herms, Stefan, additional, Hoffmann, Per, additional, Jamain, Stephane, additional, Jiménez, Esther, additional, Kahn, Jean-Pierre, additional, Kassem, Layla, additional, Kato, Tadafumi, additional, Kelsoe, John R., additional, Kittel-Schneider, Sarah, additional, König, Barbara, additional, Kuo, Po-Hsiu, additional, Kusumi, Ichiro, additional, Laje, Gonzalo, additional, Landén, Mikael, additional, Lavebratt, Catharina, additional, Leboyer, Marion, additional, Leckband, Susan G., additional, Maj, Mario, additional, Manchia, Mirko, additional, Martinsson, Lina, additional, McCarthy, Michael J., additional, McElroy, Susan L., additional, Mitchell, Philip B., additional, Mitjans, Marina, additional, Mondimore, Francis M., additional, Monteleone, Palmiero, additional, Nievergelt, Caroline M., additional, Nöthen, Markus M., additional, Novák, Tomas, additional, O’Donovan, Claire, additional, Osby, Urban, additional, Ozaki, Norio, additional, Pfennig, Andrea, additional, Pisanu, Claudia, additional, Potash, James B., additional, Reif, Andreas, additional, Reininghaus, Eva, additional, Rietschel, Marcella, additional, Rouleau, Guy A., additional, Rybakowski, Janusz K., additional, Schalling, Martin, additional, Schofield, Peter R., additional, Schubert, Klaus Oliver, additional, Schweizer, Barbara W., additional, Severino, Giovanni, additional, Shekhtman, Tatyana, additional, Shilling, Paul D., additional, Shimoda, Katzutaka, additional, Simhandl, Christian, additional, Slaney, Claire M., additional, Squassina, Alessio, additional, Stamm, Thomas, additional, Stopkova, Pavla, additional, Tortorella, Alfonso, additional, Turecki, Gustavo, additional, Vieta, Eduard, additional, Witt, Stephanie H., additional, Zandi, Peter P., additional, Fullerton, Janice M., additional, Alda, Martin, additional, Frye, Mark A., additional, Schulze, Thomas G., additional, McMahon, Francis J., additional, and Biernacka, Joanna M., additional
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- 2021
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250. Lithium's antiviral effects:a potential drug for CoViD-19 disease?
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Murru, Andrea, Manchia, Mirko, Hajek, Tomas, Nielsen, René E, Rybakowski, Janusz K, Sani, Gabriele, Schulze, Thomas G, Tondo, Leonardo, and Bauer, Michael
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Coronavirus ,CoViD-19 ,Bipolar disorder ,GSK-3β ,Inositol ,Virus - Abstract
BACKGROUND: Since its introduction in modern medicine, naturalistic observations emerged about possible uses of lithium treatment for conditions different from recurring affective disorders, for which it is still a first-line treatment option. Some evidence about the antiviral properties of lithium began in the early 1970s, when some reports found a reduction of labial-herpetic recurrences. The present review aims to present most of the pre-clinical and clinical evidence about lithium's ability to inhibit DNA and RNA viruses, including Coronaviridae, as well as the possible pathways and mechanisms involved in such antiviral activity.MAIN BODY: Despite a broad number of in vitro studies, the rationale for the antiviral activity of lithium failed to translate into methodologically sound clinical studies demonstrating its antiviral efficacy. In addition, the tolerability of lithium as an antiviral agent should be addressed. In fact, treatment with lithium requires continuous monitoring of its serum levels in order to prevent acute toxicity and long-term side effects, most notably affecting the kidney and thyroid. Yet lithium reaches heterogeneous but bioequivalent concentrations in different tissues, and the anatomical compartment of the viral infection might underpin a different, lower need for tolerability concerns which need to be addressed.CONCLUSIONS: Lithium presents a clear antiviral activity demonstrated at preclinical level, but that remains to be confirmed in clinical settings. In addition, the pleiotropic mechanisms of action of lithium may provide an insight for its possible use as antiviral agent targeting specific pathways.
- Published
- 2020
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