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Your search keyword '"Schnaas, Lourdes"' showing total 668 results
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668 results on '"Schnaas, Lourdes"'

201. Urinary 3, 5, 6-trichloro-2-pyridinol in pregnant women from Mexico City: distribution, temporal variability, and relationship with child attention/hyperactivit

Author

Fortenberry, Gamola, primary, Meeker, John D., additional, Sánchez, Brisa N., additional, Barr, Dana Boyd, additional, Bellinger, David C., additional, Schnaas, Lourdes, additional, Solano-González, Maritsa, additional, Ettinger, Adrienne, additional, Hernández-Avila, Mauricio, additional, Hu, Howard, additional, and Tellez-Rojo Solis, Martha Maria, additional

Published
2013
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203. A pilot study of prenatal urinary bisphenol A concentrations and longitudinal measures of child growth through two years in a prospective Mexico City cohort.

Author

Allan, Just, primary, Braun, Joseph, additional, Barr, Dana Boyd, additional, Svensson, Katherine, additional, Schnaas, Lourdes, additional, Cantoral Preciado, Alejandra, additional, Tellez-Rojo Solis, Martha Maria, additional, Baccarelli, Andrea A, additional, and Wright, Robert O., additional

Published
2013
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209. Childhood Blood Lead Levels and Symptoms of Attention Deficit Hyperactivity Disorder (ADHD): A Cross-Sectional Study of Mexican Children.

Author

Siying Huang, Howard Hu, Sánchez, Brisa N., Peterson, Karen E., Ettinger, Adrienne S., Lamadrid-Figueroa, Héctor, Schnaas, Lourdes, Mercado-García, Adriana, Wright, Robert O., Basu, Niladri, Cantonwine, David E., Hernández-Avila, Mauricio, and Téllez-Rojo, Martha María

Subjects
RISK factors of attention-deficit hyperactivity disorder, CHILD behavior, CONFIDENCE intervals, STATISTICAL correlation, HISPANIC Americans, LEAD, MASS spectrometry, RESEARCH funding, STATISTICAL hypothesis testing, ENVIRONMENTAL exposure, CROSS-sectional method, DATA analysis software, DESCRIPTIVE statistics, CHILDREN
Abstract

BACKGROUND: Previous studies suggest that blood lead levels are positively associated with attention deficit/hyperactivity disorder (ADHD) and ADHD-symptoms in children. However, the associations between lead exposure and ADHD subtypes are inconsistent and understudied. OBJECTIVE: The objective of this study was to explore the association of low-level concurrent lead exposure with subtypes of ADHD symptoms in 578 Mexican children 6-13 years of age. METHODS: We measured concurrent blood lead levels using inductively coupled plasma mass spectrometry (ICPMS). We administered the Conners' Rating Scales-Revised (CRS-R) to mothers to evaluate their children's ADHD symptoms. We used imputation to fill missing values in blood lead levels and used segmented regression models adjusted for relevant covariates to model the nonlinear relationship between blood lead and ADHD symptoms. RESULTS: Mean ± SD blood lead levels were 3.4 ± 2.9 µg/dL. In adjusted models, a 1-µg/dL increase in blood lead was positively associated with Hyperactivity and Restless-Impulsivity scores on the CRS-R scale and Hyperactivity-Impulsivity scores on the CRS-R scale of the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, but only in children with blood lead level ≤ 5 µg/dL. Blood lead was not associated with Inattentive symptoms or overall ADHD behavior. CONCLUSIONS: In this population of Mexican children, current blood lead level among children with low exposure (≤ 5 µg/dL) was positively associated with hyperactive/impulsive behaviors, but not with inattentiveness. These results add to the existing evidence of lead-associated neurodevelopmental deficits at low levels of exposure. CITATION: Huang S, Hu H, Sánchez BN, Peterson KE, Ettinger AS, Lamadrid-Figueroa H, Schnaas L, Mercado-García A, Wright RO, Basu N, Cantonwine DE, Hernández-Avila M, Téllez-Rojo MM. 2016. Childhood blood lead levels and symptoms of attention deficit hyperactivity disorder (ADHD): a cross-sectional study of Mexican children. Environ Health Perspect 124:868-874; http://dx.doi.org/10.1289/ehp.1510067 [ABSTRACT FROM AUTHOR]

Published
2016
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210. Secondary Hyperparathyroidism Induced by Plateletpheresis in Donors As a Result of Divalent Cationic Chelation by Citrate.

Author

Sanchez-Guerrero, Sergio, primary, Zapata-Canto, Nidia, additional, Tolentino-Dolores, Maricruz, additional, Barbosa-Ibarra, Arlette, additional, Volkow-Fernandez, Patricia, additional, Juan, Labardini, additional, Zamora-Sanchez, Lizbeth, additional, Alonso-Lopez, Alma, additional, Rivas-Pichon, Eloisa, additional, Buendia-Gomez, Leticia, additional, Damian-Yañez, Delfina, additional, Ortiz, Claudia Angel, additional, Samano-Samano, Reyna, additional, Morales, Rosa M, additional, and Schnaas, Lourdes, additional

Published
2012
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211. E-023

Author

XU, Jian, primary, Jian, Xu, additional, Cao, Sirui, additional, Sánchez, Brisa N., additional, Schnaas, Lourdes, additional, Bellinger, David, additional, Park, Sung Kyun, additional, Wright, Robert O., additional, Lamadrid-Figueroa, Hector, additional, Hernandez-Avila, Mauricio, additional, Hu, Howard, additional, Tellez-Rojo, Martha Maria, additional, and Martisa, Solano-González, additional

Published
2012
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212. P-273

Author

Vazquez-Salas, Ruth Argelia, primary, Torres-Sanchez, Luisa, additional, Menezes-Filho, Jose Antonio, additional, López Carrillo, Lizbeth, additional, Rothenberg, Stephen J, additional, Schnaas, Lourdes, additional, and Cebrian, Mariano E, additional

Published
2012
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213. P-072

Author

Osorio, Erika, primary, Torres-Sánchez, Luisa, additional, del Carmen Hernández, María, additional, López-Carrillo, Lizbeth, additional, Schnaas, Lourdes, additional, and Cebriàn, Mariano, additional

Published
2012
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214. P-411

Author

Zhang, Aimin, primary, Hu, Howard, additional, Sanchez, Brisa N, additional, Ettinger, Adrienne S, additional, Park, Sung Kyun, additional, Cantonwine, David, additional, Schnaas, Lourdes, additional, Wright, Robert O., additional, Lamadrid-Figueroa, Hector, additional, and Tellez-Rojo, Martha Maria, additional

Published
2012
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215. ENVIRONMENTAL LEAD EXPOSURE AND ODDS OF EARLIER PUBERTAL ONSET

Author

Afeiche, Myriam, primary, Peterson, Karen E, additional, Cantonwine, David, additional, Sánchez, Brisa N, additional, Ettinger, Adrienne S, additional, Sagiv, Sharon, additional, Rueda, Gabriela, additional, Chavarro, Jorge, additional, Schnaas, Lourdes, additional, Lamadrid-Figueroa, Hector, additional, Hu, Howard, additional, Hernández-Avila, Mauricio, additional, and Téllez-Rojo, Martha María, additional

Published
2011
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218. INFLUENCE OF IN UTERO AND CHILDHOOD LEAD EXPOSURE ON BODY MASS INDEX AND WAIST CIRCUMFERENCE AT AGES 7-15 YR

Author

Peterson, Karen E., primary, Weber, Kat, additional, Sánchez, Brisa N., additional, Afeiche, Myriam, additional, Ettinger, Adrienne, additional, Schnaas, Lourdes, additional, Cantonwine, David, additional, Mercado-García, Adrianna, additional, Hernández-Avila, Mauricio, additional, Hu, Howard, additional, and Téllez-Rojo, Martha M., additional

Published
2011
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224. Early Postnatal Blood Manganese Levels and Children's Neurodevelopment

Author

Claus Henn, Birgit, primary, Ettinger, Adrienne S., additional, Schwartz, Joel, additional, Téllez-Rojo, Martha María, additional, Lamadrid-Figueroa, Héctor, additional, Hernández-Avila, Mauricio, additional, Schnaas, Lourdes, additional, Amarasiriwardena, Chitra, additional, Bellinger, David C., additional, Hu, Howard, additional, and Wright, Robert O., additional

Published
2010
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232. Prenatal Lead Exposure Modifies the Impact of Maternal Self-Esteem on Children's Inattention Behavior.

Author

Xu, Jian, Hu, Howard, Wright, Rosalind, Sánchez, Brisa N., Schnaas, Lourdes, Bellinger, David C., Park, Sung Kyun, Martínez, Sandra, Hernández-Avila, Mauricio, Téllez-Rojo, Martha Maria, and Wright, Robert O.

Abstract

Objective: To prospectively evaluate the association of maternal self-esteem measured when their offspring were toddlers with the subsequent development of attention deficit hyperactivity disorder (ADHD)-like behavior in their school-age offspring and the potential modifying effects of prenatal lead exposure. Study Design: We evaluated a subsample of 192 mother-child pairs from a long-running birth-cohort project that enrolled mothers in Mexico from 1994-2011. Prenatal lead exposure was assessed using cord blood lead and maternal bone lead around delivery (tibia and patella lead, measured by K-x-ray-fluorescence). When children were 2 years old, maternal self-esteem was measured using the Coopersmith Self-Esteem Inventory. When children were 7-15 years old, children's blood lead levels and ADHD symptoms were assessed, and Conners' Parent Rating Scale-Revised and Behavior Rating Inventory of Executive Function-Parent Form were used as measures of ADHD-like behavior. Results: Adjusting for family economic status, marital status, maternal education and age, child's age and sex, and children's current blood lead levels, increased maternal self-esteem was associated with reduced child inattention behavior. Compared with those among high prenatal lead exposure (P25-P100), this association was stronger among low prenatal lead exposure groups (P1-P25, P values for the interaction effects between prenatal lead exposure and maternal self-esteem levels of <.10). Each 1-point increase in maternal self-esteem scores was associated with 0.6- to 1.3-point decrease in Conners' Parent Rating Scale-Revised and Behavior Rating Inventory of Executive Function-Parent Form T-scores among groups with low cord blood lead and patella lead (P1-P25). Conclusions: Children experiencing high maternal self-esteem during toddlerhood were less likely to develop inattention behavior at school age. Prenatal lead exposure may play a role in attenuating this protective effect. [ABSTRACT FROM AUTHOR]

Published
2015
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237. Low-Level Environmental Lead Exposure and Children’s Intellectual Function: An International Pooled Analysis

Author

Lanphear, Bruce P., primary, Hornung, Richard, additional, Khoury, Jane, additional, Yolton, Kimberly, additional, Baghurst, Peter, additional, Bellinger, David C., additional, Canfield, Richard L., additional, Dietrich, Kim N., additional, Bornschein, Robert, additional, Greene, Tom, additional, Rothenberg, Stephen J., additional, Needleman, Herbert L., additional, Schnaas, Lourdes, additional, Wasserman, Gail, additional, Graziano, Joseph, additional, and Roberts, Russell, additional

Published
2005
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242. Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment

Author

Wang, Zhaoxi, Henn, Birgit Claus, Wang, Chaolong, Wei, Yongyue, Su, Li, Sun, Ryan, Chen, Han, Wagner, Peter J., Lu, Quan, Lin, Xihong, Wright, Robert, Bellinger, David, Kile, Molly, Mazumdar, Maitreyi, Tellez-Rojo, Martha Maria, Schnaas, Lourdes, and Christiani, David C.

Subjects
Genome-wide association study, Gene-environment interactions, Child development, Lead poisoning, Single nucleotide polymorphism, UNC5D, SLC1A5, Environmental health
Abstract

Background: Neurodevelopment is a complex process involving both genetic and environmental factors. Prenatal exposure to lead (Pb) has been associated with lower performance on neurodevelopmental tests. Adverse neurodevelopmental outcomes are more frequent and/or more severe when toxic exposures interact with genetic susceptibility. Methods: To explore possible loci associated with increased susceptibility to prenatal Pb exposure, we performed a genome-wide gene-environment interaction study (GWIS) in young children from Mexico (n = 390) and Bangladesh (n = 497). Prenatal Pb exposure was estimated by cord blood Pb concentration. Neurodevelopment was assessed using the Bayley Scales of Infant Development. Results: We identified a locus on chromosome 8, containing UNC5D, and demonstrated evidence of its genome-wide significance with mental composite scores (rs9642758, p meta = 4.35 × 10−6). Within this locus, the joint effects of two independent single nucleotide polymorphisms (SNPs, rs9642758 and rs10503970) had a p-value of 4.38 × 10−9 for mental composite scores. Correlating GWIS results with in vitro transcriptomic profiles identified one common gene, SLC1A5, which is involved in synaptic function, neuronal development, and excitotoxicity. Further analysis revealed interconnected interactions that formed a large network of 52 genes enriched with oxidative stress genes and neurodevelopmental genes. Conclusions: Our findings suggest that certain genetic polymorphisms within/near genes relevant to neurodevelopment might modify the toxic effects of Pb exposure via oxidative stress. Electronic supplementary material The online version of this article (doi:10.1186/s12940-017-0288-3) contains supplementary material, which is available to authorized users.

Published
2017
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