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Twenty multiple sclerosis patients (14 female, 6 male) were involved in the study, their ages ranging rom 29 to 47 years. Ten participants formed the therapy group, and 10 the control group. The groups were comparable on the standard neurological classification scheme Expanded Disability Status Scale (EDSS). Exclusion criteria were pregnancy and mental disorders requiring medication. Measurements were taken before therapy began (T1), and subsequently every 3 months (T2-T4). This battery included indicators of clinical depression and anxiety (Beck Depression Inventory and Hospital Anxiety and Depression Scale), a self-acceptance scale (SESA) and a life quality assessment (Hamburg Quality of Life Questionnaire in Multiple Sclerosis). In addition, data were collected on cognitive (MSFC) and functional (EDSS) parameters. Patients in the therapy group received 3 blocks of music therapy in single sessions over the course of the one year project (8 to 10 sessions respectively). The music therapy approach used for this study is based on the Nordoff Robbins approach (Nordoff & Robbins, 1977). There was no significant difference between the music therapy treatment group and the control group. However, the effect size statistics comparing both groups show a medium effect size on the scales measuring self esteem (d = 0.5423, r = .026), depression HAD-D (d = 0.63, r = 0.310) and anxiety HAD-A (d = 0.63, r = 0.310). Significant improvements were found for the therapy group over time (T1-T4) in the scale values of self esteem, depression, and anxiety. Given the stigmatizing effect of a chronic degenerative disease, the positive benefits of music therapy point to a realm of aesthetic considerations in assessing clinical improvement.