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201. Renal Resistive Index Predicts Postoperative Blood Pressure Outcome in Primary Aldosteronism

Author

Iwakura, Yoshitsugu, primary, Ito, Sadayoshi, additional, Morimoto, Ryo, additional, Kudo, Masataka, additional, Ono, Yoshikiyo, additional, Nezu, Masahiro, additional, Takase, Kei, additional, Seiji, Kazumasa, additional, Ishidoya, Shigeto, additional, Arai, Yoichi, additional, Funamizu, Yasuharu, additional, Miki, Takashi, additional, Nakamura, Yasuhiro, additional, Sasano, Hironobu, additional, and Satoh, Fumitoshi, additional

Published
2016
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202. Time course and factors predicting arterial stiffness reversal in patients with aldosterone-producing adenoma after adrenalectomy: prospective study of 102 patients

Author

Liao, Che-Wei, primary, Lin, Lian-Yu, additional, Hung, Chi-Sheng, additional, Lin, Yen-Tin, additional, Chang, Yi-Yao, additional, Wang, Shuo-Meng, additional, Wu, Vin-Cent, additional, Wu, Kwan-Dun, additional, Ho, Yi-Lwun, additional, Satoh, Fumitoshi, additional, and Lin, Yen-Hung, additional

Published
2016
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203. Intratumoral heterogeneity of steroidogenesis in aldosterone-producing adenoma revealed by intensive double- and triple-immunostaining for CYP11B2/B1 and CYP17

Author

Nakamura, Yasuhiro, primary, Kitada, Masaaki, additional, Satoh, Fumitoshi, additional, Maekawa, Takashi, additional, Morimoto, Ryo, additional, Yamazaki, Yuto, additional, Ise, Kazue, additional, Gomez-Sanchez, Celso E., additional, Ito, Sadayoshi, additional, Arai, Yoichi, additional, Dezawa, Mari, additional, and Sasano, Hironobu, additional

Published
2016
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206. Calibration and evaluation of routine methods by serum certified reference material for aldosterone measurement in blood

Author

Nishikawa, Tetsuo, primary, Omura, Masao, additional, Kawaguchi, Migaku, additional, Takatsu, Akiko, additional, Satoh, Fumitoshi, additional, Ito, Sadayoshi, additional, Kurihara, Isao, additional, Itoh, Hiroshi, additional, Yanase, Toshihiko, additional, Shibata, Hirotaka, additional, Oki, Yutaka, additional, Naruse, Mitsuhide, additional, Sakurai, Keiko, additional, Sasamoto, Hidehiko, additional, and Kuwa, Katsuhiko, additional

Published
2016
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208. Cellular and Genetic Causes of Idiopathic Hyperaldosteronism.

Author

Kei Omata, Fumitoshi Satoh, Ryo Morimoto, Sadayoshi Ito, Yuto Yamazaki, Yasuhiro Nakamura, Anand, Sharath K., Guo, Zeng, Stowasser, Michael, Sasano, Hironobu, Tomlins, Scott A., Rainey, William E., Omata, Kei, Satoh, Fumitoshi, Morimoto, Ryo, Ito, Sadayoshi, Yamazaki, Yuto, and Nakamura, Yasuhiro

Abstract

Primary aldosteronism affects ≈5% to 10% of hypertensive patients and has unilateral and bilateral forms. Most unilateral primary aldosteronism is caused by computed tomography-detectable aldosterone-producing adenomas, which express CYP11B2 (aldosterone synthase) and frequently harbor somatic mutations in aldosterone-regulating genes. The cause of the most common bilateral form of primary aldosteronism, idiopathic hyperaldosteronism (IHA), is believed to be diffuse hyperplasia of aldosterone-producing cells within the adrenal cortex. Herein, a multi-institution cohort of 15 IHA adrenals was examined with CYP11B2 immunohistochemistry and next-generation sequencing. CYP11B2 immunoreactivity in adrenal glomerulosa harboring non-nodular hyperplasia was only observed in 4/15 IHA adrenals suggesting that hyperplasia of CYP11B2-expressing cells may not be the major cause of IHA. However, the adrenal cortex of all IHA adrenals harbored at least 1 CYP11B2-positive aldosterone-producing cell cluster (APCC) or micro-aldosterone-producing adenomas. The number of APCCs per case (and individual APCC area) in IHA adrenals was significantly larger than in normotensive controls. Next-generation sequencing of DNA from 99 IHA APCCs demonstrated somatic mutations in genes encoding the L-type calcium voltage-gated channel subunit α 1-D ( CACNA1D, n=57; 58%) and potassium voltage-gated channel subfamily J-5 ( KCNJ5, n=1; 1%). These data suggest that IHA may result from not only hyperplasia but also the accumulation or enlargement of computed tomography-undetectable APCC harboring somatic aldosterone-driver gene mutations. The high prevalence of mutations in the CACNA1D L-type calcium channel provides a potential actionable therapeutic target that could complement mineralocorticoid blockade and inhibit aldosterone overproduction in some IHA patients. [ABSTRACT FROM AUTHOR]

Published
2018
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209. Computed Tomography and Adrenal Venous Sampling in the Diagnosis of Unilateral Primary Aldosteronism.

Author

Adolf, Christian, Heinrich, Daniel A., Reincke, Martin, Williams, Tracy A., Beuschlein, Felix, Fallo, Francesco, Giacchetti, Gilberta, Saint-Hilary, Gaëlle, Jansen, Pieter M., Stowasser, Michael, Januszewicz, Andrzej, Kocjan, Tomaz, Nishikawa, Tetsuo, Quinkler, Marcus, Satoh, Fumitoshi, Umakoshi, Hironobu, Burrello, Jacopo, Mulatero, Paolo, Widimský, Jiří, and Hahner, Stefanie

Abstract

Unilateral primary aldosteronism is the most common surgically correctable form of endocrine hypertension and is usually differentiated from bilateral forms by adrenal venous sampling (AVS) or computed tomography (CT). Our objective was to compare clinical and biochemical postsurgical outcomes of patients with unilateral primary aldosteronism diagnosed by CT or AVS and identify predictors of surgical outcomes. Patient data were obtained from 18 internationally distributed centers and retrospectively analyzed for clinical and biochemical outcomes of adrenalectomy of patients with surgical management based on CT (n=235 patients, diagnosed from 1994-2016) or AVS (526 patients, diagnosed from 1994-2015) using the standardized PASO (Primary Aldosteronism Surgical Outcome) criteria. Biochemical outcomes were highly different according to surgical management approach with a smaller proportion in the CT group achieving complete biochemical success (188 of 235 [80%] patients versus 491 of 526 [93%], P<0.001) and a greater proportion with absent biochemical success (29 of 235 [12%] versus 10 of 526 [2%], P<0.001). A diagnosis by CT was associated with a decreased likelihood of complete biochemical success compared with AVS (odds ratio, 0.28; 0.16-0.50; P<0.001). Clinical outcomes were not significantly different, but the absence of a postsurgical elevated aldosterone-to-renin ratio was a strong marker of complete clinical success (odds ratio, 14.81; 1.76-124.53; P=0.013) in the CT but not in the AVS group. In conclusion, patients diagnosed by CT have a decreased likelihood of achieving complete biochemical success compared with a diagnosis by AVS. [ABSTRACT FROM AUTHOR]

Published
2018
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210. UNILATERALLY SELECTIVE ADRENAL VEIN SAMPLING FOR IDENTIFICATION OF SURGICALLY CURABLE PRIMARY ALDOSTERONISM.

Author

Rossi, Gian Paolo, Bagordo, Domenico, Amar, Laurence, Azizi, Michel, Riester, Anna, Reincke, Martin, Degenhart, Christoph, Widimsky, Jiri, Naruse, Mitsuhide, Deinum, Jaap, Kocjan, Tomaz, Negro, Aurelio, Rossi, Ermanno, Kline, Gregory, Tanabe, Akiyo, Satoh, Fumitoshi, Rump, Lars Christian, Vonend, Oliver, Willenberg, Holger S., and Fuller, Peter J.

Published
2023
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212. Liquid chromatography-tandem mass spectrometry analysis of human adrenal vein corticosteroids before and after ACTH stimulation

Author

Nakamura, Yasuhiro, Rege, Juilee, Satoh, Fumitoshi, Morimoto, Ryo, Kennedy, Michael R, Ahlem, Clarence N, Honma, Seijiro, Sasano, Hironobu, and Rainey, William E

Subjects
Male, Adrenocorticotropic Hormone, Adrenal Cortex Hormones, Tandem Mass Spectrometry, Humans, Female, Iliac Vein, Middle Aged, Article, Chromatography, Liquid
Abstract

Although steroid hormones produced by the adrenal gland play critical roles in human physiology, a detailed quantitative analysis of the steroid products has not been reported. The current study uses a single methodology (liquid chromatography-tandem mass spectrometry, LC-MS/MS) to quantify ten corticosteroids in adrenal vein (AV) samples pre- and post-adrenocorticotropic hormone (ACTH) stimulation.Three men and six women with a diagnosis of an adrenal aldosterone-producing adenoma (APA) were included in the study. Serum was collected from the iliac vein (IV) and the AV contralateral to the diseased adrenal. Samples were collected, before and after administration of ACTH. LC-MS/MS was then used to quantify serum concentrations of unconjugated corticosteroids and their precursors.Prior to ACTH stimulation, the four most abundant steroids in AV were cortisol (90%), cortisone (4%), corticosterone (3%) and 11-deoxycortisol (0.8%). Post-ACTH administration, cortisol remained the major adrenal product (79%); however, corticosterone became the second most abundantly produced adrenal steroid (11%) followed by pregnenolone (2.5%) and 17α-hydroxypregnenolone (2%). ACTH significantly increased the absolute adrenal output of all ten corticosteroids measured (P0.05). The four largest post-ACTH increases were pregnenolone (300-fold), progesterone (199-fold), 17α-hydroxypregnenolone (187-fold) and deoxycorticosterone (82-fold).Using LC-MS/MS, we successfully measured 10 corticosteroids in peripheral and AV serum samples under pre- and post-ACTH stimulation. This study demonstrates the primary adrenal steroid products and their response to ACTH.

Published
2012

213. Is there a role for segmental adrenal venous sampling and adrenal sparing surgery in patients with primary aldosteronism?

Author

Satoh, Fumitoshi, primary, Morimoto, Ryo, additional, Seiji, Kazumasa, additional, Satani, Nozomi, additional, Ota, Hideki, additional, Iwakura, Yoshitsugu, additional, Ono, Yoshikiyo, additional, Kudo, Masataka, additional, Nezu, Masahiro, additional, Omata, Kei, additional, Tezuka, Yuta, additional, Kawasaki, Yoshihide, additional, Ishidoya, Shigeto, additional, Arai, Yoichi, additional, Takase, Kei, additional, Nakamura, Yasuhiro, additional, McNamara, Keely, additional, Sasano, Hironobu, additional, and Ito, Sadayoshi, additional

Published
2015
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214. Abstract MP10: Nobelty and Significance of the Rapid Measurement of Plasma Aldosterone Concentration and Active Renin Concentration

Author

Satoh, Fumitoshi, primary, Ono, Yoshikiyo, additional, Morimoto, Ryo, additional, Iwakura, Yoshitsugu, additional, Nezu, Masahiro, additional, Omata, Kei, additional, Tezuka, Yuta, additional, Kudo, Masataka, additional, Seiji, Kazumasa, additional, Takase, Kei, additional, Nakamura, Yasuhiro, additional, Gomez-Sanchez, Celso E, additional, Sasano, Hironobu, additional, and Ito, Sadayoshi, additional

Published
2015
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217. Dynamic multidetector CT and non-contrast-enhanced MR for right adrenal vein imaging: comparison with catheter venography in adrenal venous sampling

Author

Ota, Hideki, primary, Seiji, Kazumasa, additional, Kawabata, Masahiro, additional, Satani, Nozomi, additional, Omata, Kei, additional, Ono, Yoshikiyo, additional, Iwakura, Yoshitsugu, additional, Morimoto, Ryo, additional, Matsuura, Tomonori, additional, Kudo, Masataka, additional, Tominaga, Junya, additional, Satoh, Fumitoshi, additional, Ito, Sadayoshi, additional, and Takase, Kei, additional

Published
2015
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218. Adrenocortical Carcinoma

Author

Nakamura, Yasuhiro, primary, Yamazaki, Yuto, additional, Felizola, Saulo J., additional, Ise, Kazue, additional, Morimoto, Ryo, additional, Satoh, Fumitoshi, additional, Arai, Yoichi, additional, and Sasano, Hironobu, additional

Published
2015
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220. Clinical significance of contralateral adrenal suppression during adrenal vein sampling in primary aldosteronism

Author

Monticone, Silvia, primary, Satoh, Fumitoshi, additional, Viola, Andrea, additional, Fischer, Eveline, additional, Vonend, Oliver, additional, Bernini, Giampaolo, additional, Quinkler, Marcus, additional, Giacchetti, Gilberta, additional, Morimoto, Ryo, additional, Willemberg, Holger, additional, Maccario, Mauro, additional, Veglio, Franco, additional, Ito, Sadayoshi, additional, Reincke, Martin, additional, and Mulatero, Paolo, additional

Published
2015
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221. Measurement of Peripheral Plasma 18-Oxocortisol Can Discriminate Unilateral Adenoma From Bilateral Diseases in Patients With Primary Aldosteronism

Author

Satoh, Fumitoshi, primary, Morimoto, Ryo, additional, Ono, Yoshikiyo, additional, Iwakura, Yoshitsugu, additional, Omata, Kei, additional, Kudo, Masataka, additional, Takase, Kei, additional, Seiji, Kazumasa, additional, Sasamoto, Hidehiko, additional, Honma, Seijiro, additional, Okuyama, Mitsunobu, additional, Yamashita, Kouwa, additional, Gomez-Sanchez, Celso E., additional, Rainey, William E., additional, Arai, Yoichi, additional, Sasano, Hironobu, additional, Nakamura, Yasuhiro, additional, and Ito, Sadayoshi, additional

Published
2015
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222. Relationship of Ocular Microcirculation, Measured by Laser Speckle Flowgraphy, and Silent Brain Infarction in Primary Aldosteronism

Author

Kunikata, Hiroshi, primary, Aizawa, Naoko, additional, Kudo, Masataka, additional, Mugikura, Shunji, additional, Nitta, Fumihiko, additional, Morimoto, Ryo, additional, Iwakura, Yoshitsugu, additional, Ono, Yoshikiyo, additional, Satoh, Fumitoshi, additional, Takahashi, Hidetoshi, additional, Ito, Sadayoshi, additional, Takahashi, Shoki, additional, and Nakazawa, Toru, additional

Published
2015
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223. Rapid Screening of Primary Aldosteronism by a Novel Chemiluminescent Immunoassay.

Author

Ryo Morimoto, Yoshikiyo Ono, Masataka Kudo, Sadayoshi Ito, Yuta Tezuka, Fumitoshi Satoh, Sachiko Yamamoto, Toshiaki Arai, Gomez-Sanchez, Celso E., Hironobu Sasano, Morimoto, Ryo, Ono, Yoshikiyo, Tezuka, Yuta, Kudo, Masataka, Yamamoto, Sachiko, Arai, Toshiaki, Sasano, Hironobu, Ito, Sadayoshi, and Satoh, Fumitoshi

Abstract

Measurement of plasma aldosterone and renin concentration, or activity, is useful for selecting antihypertensive agents and detecting hyperaldosteronism in hypertensive patients. However, it takes several days to get results when measured by radioimmunoassay and development of more rapid assays has been long expected. We have developed chemiluminescent enzyme immunoassays enabling the simultaneous measurement of both aldosterone and renin concentrations in 10 minutes by a fully automated assay using antibody-immobilized magnetic particles with quick aggregation and dispersion. We performed clinical validation of diagnostic ability of this newly developed assay-based screening of 125 patients with primary aldosteronism from 97 patients with essential hypertension. Results of this novel assay significantly correlated with the results of radioimmunoassay (aldosterone, active renin concentration, and renin activity) and liquid chromatography-tandem mass spectrometry (aldosterone). The analytic sensitivity of this particularly novel active renin assay was 0.1 pg/mL, which was better than that of radioimmunoassay (2.0 pg/mL). The ratio of aldosterone-to-renin concentrations of 6.0 (ng/dL per pg/mL) provided 92.0% sensitivity and 76.3% specificity as a cutoff for differentiating primary aldosteronism from essential hypertension. This novel measurement is expected to be a clinically reliable alternative for conventional radioimmunoassay and to provide better throughput and cost effectiveness in diagnosis of hyperaldosteronism from larger numbers of hypertensive patients in clinical settings. [ABSTRACT FROM AUTHOR]

Published
2017
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224. Aldosterone-Producing Adenomas: Genotypes and Phenotypes.

Author

Fumitoshi Satoh, Hironobu Sasano, Yuto Yamazaki, Sadayoshi Ito, Satoh, Fumitoshi, Sasano, Hironobu, Yamazaki, Yuto, and Ito, Sadayoshi

Abstract

The article discusses a study by T.G. Chin and others published within the periodical related to origin of aldosterone-producing adenomas (APAs) and relevance of APA genotypes and phenotypes and kinds of ion channels involved in aldosterone biosynthesis such as ATP1A1, CACNA1D and KCNJ5.

Published
2017
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225. Anatomical Variations of the Right Adrenal Vein: Concordance Between Multidetector Computed Tomography and Catheter Venography.

Author

Kensuke Omura, Hideki Ota, Yuuki Takahashi, Tomonori Matsuura, Kazumasa Seiji, Yoichi Arai, Ryo Morimoto, Fumitoshi Satoh, Kei Takase, Omura, Kensuke, Ota, Hideki, Takahashi, Yuuki, Matsuura, Tomonori, Seiji, Kazumasa, Arai, Yoichi, Morimoto, Ryo, Satoh, Fumitoshi, and Takase, Kei

Abstract

Adrenal venous sampling is the most reliable diagnostic procedure to determine surgical indications in primary aldosteronism. Because guidelines recommend multidetector computed tomography (CT) to evaluate the adrenal gland, some past reports used multidetector CT as a guide for adrenal venous sampling. However, the detailed anatomy of the right adrenal vein and its relationship with an accessory hepatic vein remains uncertain. The purpose of this study was to describe detailed anatomical variations of the right adrenal vein and to determine the concordance between CT and catheter venography in patients with primary aldosteronism. In total, 440 consecutive patients who underwent adrenal venous sampling were included. Four-phase dynamic CT was performed. Anatomical locations and variations of the right adrenal vein and its relationship with the accessory hepatic vein were compared with catheter venographic findings. Successful catheterization was achieved in 437 patients (99%). The right adrenal vein was visualized in the late arterial phase with CT in 420 patients (95%). The right adrenal vein formed a common trunk with the accessory hepatic vein in 87 patients (20%). CT identified the correct craniocaudal level of the orifice in 354 patients (84%). Anatomical variations, location, and angle of inflow of the right adrenal vein based on CT demonstrated high concordance with catheter venography. CT may provide useful information for preparation before adrenal venous sampling. [ABSTRACT FROM AUTHOR]

Published
2017
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227. Abstract 008: Novel Pathological Diagnosis Between Aldosterone Producing Adenoma And Idiopathic Hyperaldosteronism

Author

Satoh, Fumitoshi, primary, Ono, Yoshikiyo, additional, Morimoto, Ryo, additional, Kudo, Masataka, additional, Iwakura, Yoshitsugu, additional, Omata, Kei, additional, Seiji, Kazumasa, additional, Takase, Kei, additional, Nakamura, Yasuhiro, additional, Doi, Masao, additional, Okamura, Hitoshi, additional, Gomez-Sanchez, Celso, additional, Sasano, Hironobu, additional, and Ito, Sadayoshi, additional

Published
2014
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229. Different Expression of 11β-Hydroxylase and Aldosterone Synthase Between Aldosterone-Producing Microadenomas and Macroadenomas

Author

Ono, Yoshikiyo, primary, Nakamura, Yasuhiro, additional, Maekawa, Takashi, additional, Felizola, Saulo J.A., additional, Morimoto, Ryo, additional, Iwakura, Yoshitsugu, additional, Kudo, Masataka, additional, Seiji, Kazumasa, additional, Takase, Kei, additional, Arai, Yoichi, additional, Gomez-Sanchez, Celso E., additional, Ito, Sadayoshi, additional, Sasano, Hironobu, additional, and Satoh, Fumitoshi, additional

Published
2014
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230. Adrenal CYP11B1/2 expression in primary aldosteronism: Immunohistochemical analysis using novel monoclonal antibodies

Author

Nakamura, Yasuhiro, primary, Maekawa, Takashi, additional, Felizola, Saulo J.A., additional, Satoh, Fumitoshi, additional, Qi, Xin, additional, Velarde-Miranda, Carolina, additional, Plonczynski, Maria W., additional, Ise, Kazue, additional, Kikuchi, Kumi, additional, Rainey, William E., additional, Gomez-Sanchez, Elise P., additional, Gomez-Sanchez, Celso E., additional, and Sasano, Hironobu, additional

Published
2014
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231. The pathophysiology of aldosterone-producing adenomas associated with their tumor size: the smaller, the higher expression of CYP11B2

Author

Ono, Yoshikiyo, primary, Nakamura, Yasuhiro, additional, Maekawa, Takashi, additional, Felizola, Saulo J A, additional, Morimoto, Ryo, additional, Iwakura, Yoshitsugu, additional, Kudo, Masataka, additional, Seiji, Kazumasa, additional, Takase, Kei, additional, Gomez-Sanchez, Celso E, additional, Ito, Sadayoshi, additional, Sasano, Hironobu, additional, and Satoh, Fumitoshi, additional

Published
2014
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233. Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells

Author

Matsuda, Ken, primary, Uruno, Akira, additional, Kogure, Naotaka, additional, Sugawara, Kaori, additional, Shimada, Hiroki, additional, Nezu, Masahiro, additional, Saito-Ito, Takako, additional, Iki, Yuko, additional, Kudo, Masataka, additional, Shimizu, Kyoko, additional, Sato, Ikuko, additional, Yoshikawa, Takeo, additional, Satoh, Fumitoshi, additional, Ito, Ryo, additional, Yokoyama, Atsushi, additional, Rainey, William E., additional, Saito-Hakoda, Akiko, additional, Ito, Sadayoshi, additional, and Sugawara, Akira, additional

Published
2014
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234. Aberrant gonadotropin-releasing hormone receptor (GnRHR) expression and its regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma (APA)

Author

Nakamura, Yasuhiro, primary, Hattangady, Namita G., additional, Ye, Ping, additional, Satoh, Fumitoshi, additional, Morimoto, Ryo, additional, Ito-Saito, Takako, additional, Sugawara, Akira, additional, Ohba, Koji, additional, Takahashi, Kazuhiro, additional, Rainey, William E., additional, and Sasano, Hironobu, additional

Published
2014
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235. Development of monoclonal antibodies against human CYP11B1 and CYP11B2

Author

Gomez-Sanchez, Celso E., primary, Qi, Xin, additional, Velarde-Miranda, Carolina, additional, Plonczynski, Maria W., additional, Parker, C. Richard, additional, Rainey, William, additional, Satoh, Fumitoshi, additional, Maekawa, Takashi, additional, Nakamura, Yasuhiro, additional, Sasano, Hironobu, additional, and Gomez-Sanchez, Elise P., additional

Published
2014
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236. PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues

Author

Felizola, Saulo J A, primary, Nakamura, Yasuhiro, additional, Ono, Yoshikiyo, additional, Kitamura, Kanako, additional, Kikuchi, Kumi, additional, Onodera, Yoshiaki, additional, Ise, Kazue, additional, Takase, Kei, additional, Sugawara, Akira, additional, Hattangady, Namita, additional, Rainey, William E, additional, Satoh, Fumitoshi, additional, and Sasano, Hironobu, additional

Published
2014
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239. Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: The metabotropic pathway

Author

Felizola, Saulo J.A., primary, Nakamura, Yasuhiro, additional, Satoh, Fumitoshi, additional, Morimoto, Ryo, additional, Kikuchi, Kumi, additional, Nakamura, Tomohiro, additional, Hozawa, Atsushi, additional, Wang, Lin, additional, Onodera, Yoshiaki, additional, Ise, Kazue, additional, McNamara, Keely M., additional, Midorikawa, Sanae, additional, Suzuki, Shinichi, additional, and Sasano, Hironobu, additional

Published
2014
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241. Prognosis of primary aldosteronism in Japan: results from a nationwide epidemiological study

Author

Miyake, Yoshihiro, primary, Tanaka, Keiko, additional, Nishikawa, Tetsuo, additional, Naruse, Mitsuhide, additional, Takayanagi, Ryoichi, additional, Sasano, Hironobu, additional, Takeda, Yoshiyu, additional, Shibata, Hirotaka, additional, Sone, Masakatsu, additional, Satoh, Fumitoshi, additional, Yamada, Masanobu, additional, Ueshiba, Hajime, additional, Katabami, Takuyuki, additional, Iwasaki, Yasumasa, additional, Tanaka, Hirotoshi, additional, Tanahashi, Yusuke, additional, Suzuki, Shigeru, additional, Hasegawa, Tomonobu, additional, Katsumata, Noriyuki, additional, Tajima, Toshihiro, additional, and Yanase, Toshihiko, additional

Published
2014
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246. Characterization and distribution of prolactin releasing peptide (PrRP) binding sites in the rat – evidence for a novel binding site subtype in cardiac and skeletal muscle

Author

Satoh, Fumitoshi, Smith, David M, Gardiner, James V, Mahmoodi, Mehdi, Murphy, Kevin G, Ghatei, Mohammad A, and Bloom, Stephen R

Subjects
Male, Binding Sites, Myocardium, Cell Membrane, Brain, Receptors, Cell Surface, Blotting, Northern, Rats, Receptors, G-Protein-Coupled, Iodine Radioisotopes, Molecular Weight, Papers, Animals, Humans, Cattle, Female, Tissue Distribution, RNA, Messenger, Rats, Wistar, Muscle, Skeletal, Poly A, Thyrotropin-Releasing Hormone
Abstract

Prolactin releasing peptide (PrRP) was recently purified from bovine hypothalamus and binds to the orphan receptor, UHR-1. We examined the distribution and kinetics of (125)I-PrRP binding in rat tissues together with molecular characterization by chemical cross-linking and Northern blotting. In this study (125)I-PrRP binding showed specificity and rapid association and dissociation. Specific binding was found in membranes from rat tissues including brain (hypothalamus, medulla oblongata and cerebellum), pituitary, heart, soleus muscle, adipose tissue, kidney, adrenal gland, testis and small intestine. In hypothalamus, pituitary, heart and soleus competition analysis indicated only one class of binding site in each tissue. Binding affinity for PrRP (IC(50)) and binding site density (B(max)) respectively were 5.2+/-0.9 nM and 674+/-97 fmol mg protein(-1) in hypothalamus (n = 5), 1.4+/-0.6 nM and 541+/-126 fmol mg protein(-1) in pituitary (n = 3), 6.6+/-0.7 nM and 628+/-74 fmol mg protein(-1) in heart (n = 4) and 9.8+/-0.9 nM and 677+/-121 fmol mg protein(-1) in soleus muscle (n = 4). Analysis of (125)I-PrRP-binding site complexes by chemical cross-linking showed a binding site M(r) of 69,000 in hypothalamus and 41,000 in heart and soleus. Northern analysis of polyA(+) RNA from hypothalamus showed a 4.2 kb band as expected for UHR-1, but heart and soleus showed a 4.8 kb band. Taken together these results indicate that there may be different subtypes of PrRP binding sites in rat tissues which may differ from UHR-1.

Published
2000

247. 原発性アルドステロン症診断のクリニカルパスとACTH負荷両側副腎静脈血同時採血法(原発性アルドステロン症におけるACTH負荷副腎静脈サンプリングの意義,第2回副腎静脈サンプリング研究会,プロシーディングス)

Author

SATOH, Fumitoshi, ABE, Takaaki, TANEMOTO, Masayuki, NAKAMURA, Masahiro, ABE, Michiaki, SUZUKI, Saya, MORIMOTO, Rei, CHIAKI, Tatsuji, SATO, Akihiro, TAKASE, Kei, ISHIDOYA, Shigeto, SUZUKI, Takashi, ARAI, Yoichi, SASANO, Hironobu, ISHIBASHI, Tadashi, ITO, Sadayoshi, 佐藤, 文俊, 阿部, 高明, 種本, 雅之, 中村, 匡宏, 阿部, 倫明, 鈴木, 恵綾, 森本, 玲, 茶木, 辰治, 佐藤, 明弘, 高瀬, 圭, 石戸谷, 滋人, 鈴木, 貴, 荒井, 陽一, 笹野, 公伸, 石橋, 忠司, 伊藤, 貞嘉, SATOH, Fumitoshi, ABE, Takaaki, TANEMOTO, Masayuki, NAKAMURA, Masahiro, ABE, Michiaki, SUZUKI, Saya, MORIMOTO, Rei, CHIAKI, Tatsuji, SATO, Akihiro, TAKASE, Kei, ISHIDOYA, Shigeto, SUZUKI, Takashi, ARAI, Yoichi, SASANO, Hironobu, ISHIBASHI, Tadashi, ITO, Sadayoshi, 佐藤, 文俊, 阿部, 高明, 種本, 雅之, 中村, 匡宏, 阿部, 倫明, 鈴木, 恵綾, 森本, 玲, 茶木, 辰治, 佐藤, 明弘, 高瀬, 圭, 石戸谷, 滋人, 鈴木, 貴, 荒井, 陽一, 笹野, 公伸, 石橋, 忠司, and 伊藤, 貞嘉

Published
2010

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