Search

Your search keyword '"Sato, Hirotaka"' showing total 994 results
Start Over Author "Sato, Hirotaka"
994 results on '"Sato, Hirotaka"'

204. Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions

Author

Watanabe, Satoru, primary, Fujino, Masayuki, additional, Saito, Yohei, additional, Ahmed, Nursarat, additional, Sato, Hirotaka, additional, Sugimoto, Chie, additional, Okamura, Tomotaka, additional, Hanaki, Kenichi, additional, Nakayama, Emi E., additional, Shioda, Tatsuo, additional, Matsushima, Kouji, additional, Ansari, Aftab A., additional, Villinger, Francois, additional, and Mori, Kazuyasu, additional

Published
2020
Full Text
View/download PDF

211. The energy-resolved neutron imaging system, RADEN

Author

Shinohara, Takenao, primary, Kai, Tetsuya, additional, Oikawa, Kenichi, additional, Nakatani, Takeshi, additional, Segawa, Mariko, additional, Hiroi, Kosuke, additional, Su, Yuhua, additional, Ooi, Motoki, additional, Harada, Masahide, additional, Iikura, Hiroshi, additional, Hayashida, Hirotoshi, additional, Parker, Joseph D., additional, Matsumoto, Yoshihiro, additional, Kamiyama, Takashi, additional, Sato, Hirotaka, additional, and Kiyanagi, Yoshiaki, additional

Published
2020
Full Text
View/download PDF

220. Cohort profile: Aichi regional sub-cohort of the Japan Environment and Children’s Study (JECS-A)

Author

Ebara, Takeshi, primary, Yamada, Yasuyuki, additional, Shoji, Naoto, additional, Ito, Yuki, additional, Nakagawa, Atsuko, additional, Miyachi, Taishi, additional, Ozaki, Yasuhiko, additional, Omori, Toyonori, additional, Suzuki, Sadao, additional, Kojima, Masayo, additional, Ueyama, Jun, additional, Tomizawa, Motohiro, additional, Kato, Sayaka, additional, Oguri, Tomoko, additional, Matsuki, Taro, additional, Sato, Hirotaka, additional, Oya, Naoko, additional, Sugiura-Ogasawara, Mayumi, additional, Saitoh, Shinji, additional, and Kamijima, Michihiro, additional

Published
2019
Full Text
View/download PDF

224. Construction of MR angiography using subtraction silent Ultra Short TE image

Author

Sato, Hirotaka

Subjects
Head and neck, Computer Applications-General, genetic structures, MR-Angiography, Vascular, Acute
Abstract

Aims and objectives Methods and materials Results Conclusion Personal information References, Aims and objectives: Minimizing acoustic noise utilizing Ultra Short TE (mUTE) is a 3D Gradient echo (GRE) sequence with T1 contrast that excels in silence.It has been shown that sound reduction can help reduce examination-related anxiety and allow patients to better...

Published
2019
Full Text
View/download PDF

227. Multicentric liposarcoma

Author

SATO, HIROTAKA, MINEI, SADATSUGU, SUGIMOTO, SHUJI, KISHIMOTO, YUICHI, YOSHIDA, TOSHIO, and TAKIMOTO, YUKIE

Published
2004

228. Characterization of Prototheca CYP51/ERG11 as a possible target for therapeutic drugs.

Author

Watanabe, Takahisa, Ishikawa, Tomohiro, Sato, Hirotaka, Hirose, Noriyuki, Nonaka, Lisa, Matsumura, Kaori, Masubuchi, Akira, Nishimura, Kazuko, and Masuda, Michiaki

Abstract

Prototheca spp. are achlorophyllous algae, ubiquitous in nature. An increasing number of human and animal cases of Prototheca infection (protothecosis) are reported, and antifungal azoles, which inhibit sterol 14α-demethylase (CYP51/ERG11) involved in ergosterol biosynthesis, have empirically been used for the treatment of protothecosis. Although Prototheca , like fungi, has ergosterol in the cell membrane, efficacy of the antifungal azoles in the treatment of protothecosis is controversial. For investigating the interaction of azole drugs with Prototheca CYP51/ERG11, the CYP51/ERG11 genomic genes of four strains of P. wickerhamii and one strain each of P. cutis and P. miyajii were isolated and characterized in this study. Compared with the CYP51/ERG11 gene of chlorophyllous Auxenochlorella Protothecoides , it is possible that ProtothecaCYP51/ERG11 gene, whose exon-intron structure appeared to be species-specific, lost introns associated with the loss of photosynthetic activity. Analysis of the deduced amino acid sequences revealed that Prototheca CYP51/ERG11 and fungal CYP51/ERG11 are phylogenetically distant from each other although their overall structures are similar. Our basic in silico studies predicted that antifungal azoles could bind to the catalytic pocket of Prototheca CYP51/ERG11. It was also suggested that amino acid residues away from the catalytic pocket might affect the drug susceptibility. The results of this study may provide useful insights into the phylogenetic taxonomy of Prototheca spp. in relationship to the CYP51/ERG11 structure and development of novel therapeutic drugs for the treatment of protothecosis. Lay Summary Cases of infection by microalgae of Prototheca species are increasing. However, effective treatment has not been established yet. In this study, gene and structure of Prototheca 's CYP51/ERG11, an enzyme which might serve as a target for therapeutic drugs, were characterized for the first time. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

229. Relationship between delivery with anesthesia and postpartum depression: The Japan Environment and Children's Study (JECS).

Author

Suzumori, Nobuhiro, Ebara, Takeshi, Tamada, Hazuki, Matsuki, Taro, Sato, Hirotaka, Kato, Sayaka, Saitoh, Shinji, Kamijima, Michihiro, Sugiura-Ogasawara, Mayumi, the Japan Environment, Children's Study Group, Yamazaki, Shin, Ohya, Yukihiro, Kishi, Reiko, Yaegashi, Nobuo, Hashimoto, Koichi, Mori, Chisato, Ito, Shuichi, Yamagata, Zentaro, Inadera, Hidekuni, and Nakayama, Takeo

Subjects
ANESTHESIA, POSTPARTUM depression, ANALGESIA, LOGISTIC regression analysis, PREGNANT women
Abstract

Background: Postpartum depression is one of the most commonly experienced psychological disorders for women after childbirth, usually occurring within one year. This study aimed to clarify whether women with delivery with anesthesia, including epidural analgesia, spinal-epidural analgesia, and paracervical block, had a decreased risk of postpartum depression after giving birth in Japan.Methods: The Japan Environment and Children's Study (JECS) was a prospective cohort study that enrolled registered fetal records (n = 104,065) in 15 regions nationwide in Japan. Binomial logistic regression analyses were performed to calculate the adjusted odd ratios (aORs) for the association between mode of delivery with or without anesthesia and postpartum depression at one-, six- and twelve-months after childbirth.Results: At six months after childbirth, vaginal delivery with anesthesia was associated with a higher risk of postpartum depression (aOR: 1.233, 95% confidence interval: 1.079-1.409), compared with vaginal delivery without analgesia. Nevertheless, the risk dropped off one year after delivery. Among the pregnant women who requested delivery with anesthesia, 5.1% had a positive Kessler-6 scale (K6) score for depression before the first trimester (p < 0.001), which was significantly higher than the proportions in the vaginal delivery without analgesia (3.5%).Conclusions: Our data suggested that the risk of postpartum depression at six months after childbirth tended to be increased after vaginal delivery with anesthesia, compared with vaginal delivery without analgesia. Requests for delivery with anesthesia continue to be relatively uncommon in Japan, and women who make such requests might be more likely to experience postpartum depressive symptoms because of underlying maternal environmental statuses. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

231. Association of Maternal Total Cholesterol With SGA or LGA Birth at Term: the Japan Environment and Children’s Study

Author

Kaneko, Kayo, Ito, Yuki, Ebara, Takeshi, Kato, Sayaka, Matsuki, Taro, Tamada, Hazuki, Sato, Hirotaka, Saitoh, Shinji, Sugiura-Ogasawara, Mayumi, Yamazaki, Shin, Ohya, Yukihiro, Kishi, Reiko, Yaegashi, Nobuo, Hashimoto, Koichi, Mori, Chisato, Ito, Shuichi, Yamagata, Zentaro, Inadera, Hidekuni, Nakayama, Takeo, Iso, Hiroyasu, Shima, Masayuki, Kurozawa, Youichi, Suganuma, Narufumi, Kusuhara, Koichi, Katoh, Takahiko, and Kamijima, Michihiro

Published
2022
Full Text
View/download PDF

246. Within-individual and interlaboratory variability analyses of urinary metabolites measurements of organophosphorus insecticides

Author

Ito, Yuki, primary, Ueyama, Jun, additional, Nakayama, Shoji F, additional, Isobe, Tomohiko, additional, Oya, Naoko, additional, Sato, Hirotaka, additional, Ebara, Takeshi, additional, Yoshimasu, Kouichi, additional, Tsuno, Kanami, additional, Tatsuta, Nozomi, additional, Nakai, Kunihiko, additional, and Kamijima, Michihiro, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results