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764 results on '"Sasaki, Tsutomu"'

201. FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and β-cell-specific FoxO1 knockout mice

Author

Kobayashi, Masaki, primary, Kikuchi, Osamu, additional, Sasaki, Tsutomu, additional, Kim, Hye-Jin, additional, Yokota-Hashimoto, Hiromi, additional, Lee, Yong-Soo, additional, Amano, Kosuke, additional, Kitazumi, Tomoya, additional, Susanti, Vina Yanti, additional, Kitamura, Yukari Ido, additional, and Kitamura, Tadahiro, additional

Published
2012
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204. Potential Application of 5-Aryl-Substituted 2-Aminobenzamide Type of HDAC1/2- Selective Inhibitors to Pharmaceuticals

Author

Uesato, Shinichi, Hirata, Yoshiyuki, and Sasaki, Tsutomu

Abstract

Diverse histone deacetylase (HDAC) inhibitors have been developed to date. They control not only histone modification but also gene expression of diverse proteins and thus are expected to provide useful therapeutic effects on various diseases, including cancers, psychiatric and cognitive disorders and neurodegenerative diseases, as well as cardiovascular and diabetic diseases. Some isoform-nonselective HDAC inhibitors have been successfully used for clinical treatments of the haematological malignancies, including advanced forms of cutaneous T-cell lymphoma, refractory peripheral T-cell lymphoma and multiple myeloma. However, the nonselective HDAC inhibitors threaten to cause adverse effects, such as thrombocytopenia, nausea, fatigue and cardiotoxicity, and their influence on the health care of patients is of concern. It is therefore anticipated that the development of isoform-selective HDAC inhibitors may offer more efficacy and less toxicity. Recently, a number of 5- aryl-substituted 2-aminobenzamide series of HDAC1/2-selective inhibitors have been synthesized, and their useful biological activities have been reported. In this review, we introduce the recent development of synthetic and biological studies on 5-aryl-substituted 2-aminobenzamide-type HDAC1/2 inhibitors, together with the latest research findings on biology of broad-spectrum HDAC inhibitors. In addition, we refer to the possibility of their application in clinical therapies.

Published
2017
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205. A Potent Inhibitor of SIK2, 3, 3′, 7-Trihydroxy-4′-Methoxyflavon (4′-O-Methylfisetin), Promotes Melanogenesis in B16F10 Melanoma Cells

Author

Kumagai, Ayako, primary, Horike, Nanao, additional, Satoh, Yudai, additional, Uebi, Tatsuya, additional, Sasaki, Tsutomu, additional, Itoh, Yumi, additional, Hirata, Yoshiyuki, additional, Uchio-Yamada, Kozue, additional, Kitagawa, Kazuo, additional, Uesato, Shinichi, additional, Kawahara, Hidehisa, additional, Takemori, Hiroshi, additional, and Nagaoka, Yasuo, additional

Published
2011
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208. SIK2 Is a Key Regulator for Neuronal Survival after Ischemia via TORC1-CREB

Author

Sasaki, Tsutomu, primary, Takemori, Hiroshi, additional, Yagita, Yoshiki, additional, Terasaki, Yasukazu, additional, Uebi, Tatsuya, additional, Horike, Nanao, additional, Takagi, Hiroaki, additional, Susumu, Teruo, additional, Teraoka, Hiroshi, additional, Kusano, Ken-ichi, additional, Hatano, Osamu, additional, Oyama, Naoki, additional, Sugiyama, Yukio, additional, Sakoda, Saburo, additional, and Kitagawa, Kazuo, additional

Published
2011
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227. Author Correction: Time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 2.

Author

Todo, Kenichi, Yoshimura, Shinichi, Uchida, Kazutaka, Yamagami, Hiroshi, Sakai, Nobuyuki, Kishima, Haruhiko, Mochizuki, Hideki, Ezura, Masayuki, Okada, Yasushi, Kitagawa, Kazuo, Kimura, Kazumi, Sasaki, Makoto, Tanahashi, Norio, Toyoda, Kazunori, Furui, Eisuke, Matsumaru, Yuji, Minematsu, Kazuo, Kitano, Takaya, Okazaki, Shuhei, and Sasaki, Tsutomu

Subjects
ARTERIAL occlusions, AGE groups
Published
2021
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228. Phosphorylation Regulates SIRT1 Function

Author

Sasaki, Tsutomu, primary, Maier, Bernhard, additional, Koclega, Katarzyna D., additional, Chruszcz, Maksymilian, additional, Gluba, Wendy, additional, Stukenberg, P. Todd, additional, Minor, Wladek, additional, and Scrable, Heidi, additional

Published
2008
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249. Adenovirus-Mediated Gene Transfer of Heparin-Binding Epidermal Growth Factor-Like Growth Factor Enhances Neurogenesis and Angiogenesis After Focal Cerebral Ischemia in Rats

Author

Sugiura, Shiro, primary, Kitagawa, Kazuo, additional, Tanaka, Shigeru, additional, Todo, Kenichi, additional, Omura-Matsuoka, Emi, additional, Sasaki, Tsutomu, additional, Mabuchi, Takuma, additional, Matsushita, Kohji, additional, Yagita, Yoshiki, additional, and Hori, Masatsugu, additional

Published
2005
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