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204. Untersuchung der Cl-Leitfähigkeit in humanen primären nasalen Epithelzellen von Patienten mit chronischer Rhinosinusitis

Author

Albrecht, Tobias, Salomon, J. J., Baumann, I., and Mall, M. A.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die chronische Rhinosinusitis (CRS) ist eine der häufigsten chronischen Erkrankungen der oberen Atemwege, deren zugrunde liegenden Pathomechanismen noch nicht eindeutig identifiziert sind. Eine sinonasale Entzündung, Sekretüberproduktion oder eingeschränkter transepithelialer Ionentransport könnten eine Rolle spielen. Das Ziel dieser Studie war es, den Effekt von IL-13 auf epitheliale Chloridströme am kultivierten Nasenepithel von CRS Patienten zu untersuchen. Methoden: Polypöses Siebbeingewebe (hNEpC-SBB) wurde während eines Nasennebenhöhleneingriffs von Patienten gewonnen. Primäre nasale Epithelzellen (hNEpC) wurden isoliert und für 14 Tage kultiviert. Transepitheliale Cl-Ströme wurden in Ussing Kammer Messungen sowohl in unbehandelten sowie in mit IL-13, einem Schlüssel-Zytokin der Th2-vermittelten Entzündung, vorbehandelten Zellen gemessen. Ergebnisse: Stimulation mit IL-13 zeigte keinen Effekt auf den basalen Kurzschlussstrom (Isc) im Siebbeingewebe (18,9±1,7 vs. 20,6±2,0). Der Amilorid-sensitive Strom wurde unter IL-13 Stimulation signifikant gehemmt (2,4±0,3 vs. 1,5±0,2). Der Amilorid-insensitive Strom hingegen zeigte sich unverändert (16,3±1,6 vs. 18,9±2,0). UTP, als Agonist für Ca2+-vermittelten Cl-Sekretion erhöhte die Cl-Ströme in IL-13 stimulierten Nasalepithelzellen (0,0±0,3 vs. 2,2±0,6). Schlussfolgerung: Funktionelle Messungen der Cl-Ströme am Nasenepithel von CRS Patienten unter IL-13 Stimulation zeigten Veränderungen in der Na+ Absorption und der Cl-Sekretion, welche nun mit Messungen am Nasenepithel von gesunden Kontrollpatienten verglichen werden müssen. Eine Aufklärung einer potentiellen (dys-)Regulation des epithelialen Ionentransports in der Pathogenese der CRS könnte mit Ussing Kammer Messungen erfolgen. Der Erstautor gibt keinen Interessenkonflikt an., GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery; 12:Doc197

Published
2016
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205. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015

Author

Wang H, Bhutta Z, Coates M, Coggeshall M, Dandona L, Diallo K, Franca E, Fraser M, Fullman N, Gething P, Hay S, Kinfu Y, Kita M, Kulikoff X, Larson H, Liang J, Liang X, Lim S, Lind M, Lopez A, Lozano R, Mensah G, Mikesell J, Mokdad A, Mooney M, Naghavi M, Nguyen G, Rakovac I, Salomon J, Silpakit N, Sligar A, Sorensen R, Vos T, Zhu J, Abajobir A, Abate K, Abbas K, Abd-Allah F, Abdulle A, Abera S, Aboyans V, Abraham B, Abubakar I, Abu-Raddad L, Abu-Rmeileh N, Abyu G, Achoki T, Adebiyi A, Adedeji I, Adelekan A, Adou A, Agarwal A, Ajala O, Akinyemiju T, Akseer N, Alam K, Alam N, Alasfoor D, Aldridge R, Alegretti M, Alemu Z, Ali R, Alkerwi A, Alla F, Al-Raddadi R, Alsharif U, Altirkawi K, Martin E, Alvis-Guzman N, Amare A, Amberbir A, Amegah A, Ameh E, Ammar W, Amrock S, Andersen H, Anderson G, Antonio C, Arlov J, Artaman A, Asayesh H, Asghar R, Assadi R, Atique S, Avokpaho E, Awasthi A, Quintanilla B, Bacha U, Badawi A, Balakrishnan K, Banerjee A, Banigbe B, Barac A, Barber R, Barker-Collo S, Barnighausen T, Barrero L, Bayou T, Bayou Y, Bazargan-Hejazi S, Beardsley J, Bedi N, Bekele T, Bell M, Bello A, Bennett D, Bensenor I, Berhane A, Bernabe E, Betsu B, Beyene A, Bhatt S, Biadgilign S, Bikbov B, Birlik S, Bisanzio D, Bjertness E, Blore J, Bourne R, Brainin M, Brazinova A, Breitborde N, Brown A, Buckle G, Burch M, Butt Z, Campos-Nonato I, Campuzano J, Cardenas R, Carpenter D, Carrero J, Carter A, Casey D, Castaneda-Orjuela C, Rivas J, Castro R, Catala-Lopez F, Cercy K, Chang H, Chang J, Chibueze C, Chisumpa V, Choi J, Chowdhury R, Christopher D, Ciobanu L, Colquhoun S, Cooper C, Cornaby L, Damtew S, Danawi H, Dandona R, das Neves J, Davis A, de Jager P, De Leo D, Degenhardt L, Deribe K, Deribew A, Jarlais D, deVeber G, Dharmaratne S, Dhillon P, Ding E, Doshi P, Doyle K, Duan L, Dubey M, Ebrahimi H, Ellingsen C, Elyazar I, Endries A, Ermakov S, Eshrati B, Esteghamati A, Faraon E, Farid T, Farinha C, Faro A, Farvid M, Farzadfar F, Fereshtehnejad S, Fernandes J, Fischer F, Fitchett J, Foigt N, Franklin R, Friedman J, Furst T, Gambashidze K, Gamkrelidze A, Ganguly P, Gebre T, Gebrehiwot T, Gebremedhin A, Gebru A, Geleijnse J, Gessner B, Ginawi I, Giref A, Gishu M, Gomez-Dantes H, Gona P, Goodridge A, Gopalani S, Goto A, Gouda H, Gugnani H, Guo Y, Gupta R, Gupta V, Gyawali B, Haagsma J, Hafezi-Nejad N, Haile D, Hailu A, Hailu G, Hamadeh R, Hamidi S, Hancock J, Handal A, Hankey G, Harb H, Harikrishnan S, Harun K, Havmoeller R, Hay R, Heredia-Pi I, Hoek H, Horino M, Horita N, Hosgood H, Hotez P, Hoy D, Hsairi M, Hu G, Huang C, Huang J, Huang H, Huiart L, Huynh C, Iburg K, Idrisov B, Innos K, Jacobsen K, Jahanmehr N, Javanbakht M, Jayatilleke A, Jee S, Jeemon P, Jha V, Jiang G, Jiang Y, Jibat T, Jin Y, Jonas J, Kabir Z, Kalkonde Y, Kamal R, Kan H, Kang G, Karch A, Karema C, Kasaeian A, Kaul A, Kawakami N, Kayibanda J, Kazanjan K, Keiyoro P, Kemp A, Kengne A, Keren A, Kereselidze M, Kesavachandran C, Khader Y, Khalil I, Khan A, Khan E, Khang Y, Khonelidze I, Khubchandani J, Kim C, Kim D, Kim Y, Kissoon N, Kivipelto M, Knibbs L, Kokubo Y, Kosen S, Koul P, Koyanagi A, Defo B, Bicer B, Kudom A, Kumar G, Kutz M, Kyu H, Lal D, Lalloo R, Lam H, Lam J, Lansingh V, Larsson A, Leigh J, Leung R, Li Y, Lindsay M, Liu P, Liu S, Lloyd B, Lo W, Logroscino G, Low N, Lunevicius R, Lyons R, Ma S, Abd El Razek H, Abd El Razek M, Mahdavi M, Majdan M, Majeed A, Malekzadeh R, Mapoma C, Marcenes W, Martinez-Raga J, Marzan M, Masiye F, McGrath J, Meaney P, Mehari A, Mehndiratta M, Mekonnen A, Melaku Y, Memiah P, Memish Z, Mendoza W, Meretoja A, Meretoja T, Mhimbira F, Miller T, Mills E, Mirarefin M, Misganaw A, Mock C, Mohammad K, Mohammadi A, Mohammed S, Monasta L, Hernandez J, Montico M, Moore A, Moradi-Lakeh M, Morawska L, Mori R, Mueller U, Murphy G, Murthy S, Nachega J, Naheed A, Naidoo K, Naldi L, Nand D, Nangia V, Neupane S, Newton C, Newton J, Ng M, Ngalesoni F, Nguhiu P, Nguyen Q, Nisar M, Pete P, Norheim O, Norman R, Ogbo F, Oh I, Ojelabi F, Olivares P, Olusanya B, Olusanya J, Oren E, Ota E, Mahesh P, Park E, Park H, Parsaeian M, Caicedo A, Patten S, Pedro J, Pereira D, Perico N, Pesudovs K, Petzold M, Phillips M, Pillay J, Pishgar F, Polinder S, Pope D, Popova S, Pourmalek F, Qorbani M, Rabiee R, Rafay A, Rahimi-Movaghar V, Rahman M, Rahman S, Rai R, Raju M, Ram U, Rana S, Ranabhat C, Rao P, Refaat A, Remuzzi G, Resnikoff S, Reynolds A, Rojas-Rueda D, Ronfani L, Roshandel G, Roth G, Roy A, Ruhago G, Sagar R, Saleh M, Sanabria J, Sanchez-Nino M, Santos I, Santos J, Sarmiento-Suarez R, Sartorius B, Satpathy M, Savic M, Sawhney M, Schneider I, Schottker B, Schwebel D, Seedat S, Sepanlou S, Servan-Mori E, Setegn T, Shahraz S, Shaikh M, Shakh-Nazarova M, Sharma R, She J, Sheikhbahaei S, Shen J, Sheth K, Shibuya K, Shin H, Shin M, Shiri R, Shuie I, Sigfusdottir I, Silva D, Silverberg J, Simard E, Sindi S, Singh A, Singh J, Singh O, Singh P, Singh V, Soriano J, Soshnikov S, Sposato L, Sreeramareddy C, Stathopoulou V, Steel N, Stroumpoulis K, Sturua L, Sunguya B, Swaminathan S, Sykes B, Szoeke C, Tabares-Seisdedos R, Tavakkoli M, Taye B, Tedla B, Tefera W, Tekle T, Shifa G, Terkawi A, Tesfay F, Tessema G, Thapa K, Thomson A, Thorne-Lyman A, Tobe-Gai R, Tonelli M, Topor-Madry R, Topouzis F, Tran B, Troeger C, Truelsen T, Dimbuene Z, Tura A, Tyrovolas S, Ukwaja K, Uneke C, Uthman O, Vaezghasemi M, Vasankari T, Vasconcelos A, Venketasubramanian N, Verma R, Violante F, Vladimirov S, Vlassov V, Vollset S, Wang L, Wang Y, Weichenthal S, Weiderpass E, Weintraub R, Weiss D, Werdecker A, Westerman R, Widdowson M, Wijeratne T, Williams T, Wiysonge C, Wolfe C, Wolfe I, Won S, Wubshet M, Xiao Q, Xu G, Yadav A, Yakob B, Yano Y, Yaseri M, Ye P, Yebyo H, Yip P, Yonemoto N, Yoon S, Younis M, Yu C, Zaidi Z, Zaki M, Zeeb H, Zhang H, Zhao Y, Zheng Y, Zhou M, Zodpey S, Murray C, and GBD 2015 Child Mortality Collabora

Published
2016

206. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2015 : the Global Burden of Disease Study 2015

Author

GBD 2015 HIV Collaborators, Wang, H, Wolock, TM, Carter, A, Nguyen, G, Kyu, HH, Gakidou, E, Hay, SI, Mills, EJ, Trickey, A, Msemburi, W, Coates, MM, Mooney, MD, Fraser, MS, Sligar, A, Salomon, J, Larson, HJ, Friedman, J, Abajobir, AA, Abate, KH, Abbas, KM, Razek, MM, Abd-Allah, F, Abdulle, AM, Abera, SF, Abubakar, I, Abu-Raddad, LJ, Abu-Rmeileh, NM, Abyu, GY, Adebiyi, AO, Adedeji, IA, Adelekan, AL, Adofo, K, Adou, AK, Ajala, ON, Akinyemiju, TF, Akseer, N, Lami, FH, Al-Aly, Z, Alam, K, Alam, NK, Alasfoor, D, Aldhahri, SF, Aldridge, RW, Alegretti, MA, Aleman, AV, Alemu, ZA, Alfonso-Cristancho, R, Ali, R, Alkerwi, A, Alla, F, Mohammad, R, Al-Raddadi, S, Alsharif, U, Alvarez, E, Alvis-Guzman, N, Amare, AT, Amberbir, A, Amegah, AK, Ammar, W, Amrock, SM, Antonio, CA, Anwari, P, Ärnlöv, J, Artaman, A, Asayesh, H, Asghar, RJ, Assadi, R, Atique, S, Atkins, LS, Avokpaho, EF, Awasthi, A, Quintanilla, BP, Bacha, U, Badawi, A, Barac, A, Bärnighausen, T, Basu, A, Bayou, TA, Bayou, YT, Bazargan-Hejazi, S, Beardsley, J, Bedi, N, Bennett, DA, Bensenor, IM, Betsu, BD, Beyene, AS, Bhatia, E, Bhutta, ZA, Biadgilign, S, Bikbov, B, Birlik, SM, Bisanzio, D, Brainin, M, Brazinova, A, Breitborde, NJ, Brown, A, Burch, M, Butt, ZA, Campuzano, JC, Cárdenas, R, Carrero, JJ, Castañeda-Orjuela, CA, Rivas, JC, Catalá-López, F, Chang, HY, Chang, JC, Chavan, L, Chen, W, Chiang, PP, Chibalabala, M, Chisumpa, VH, Choi, JY, Christopher, DJ, Ciobanu, LG, Cooper, C, Dahiru, T, Damtew, SA, Dandona, L, Dandona, R, Das Neves, J, De Jager, P, De Leo, D, Degenhardt, L, Dellavalle, RP, Deribe, K, Deribew, A, Des Jarlais, DC, Dharmaratne, SD, Ding, EL, Doshi, PP, Driscoll, TR, Dubey, M, Elshrek, YM, Elyazar, I, Endries, AY, Ermakov, SP, Eshrati, B, Esteghamati, A, Faghmous, ID, Farinha, CS, Faro, A, Farvid, MS, Farzadfar, F, Fereshtehnejad, SM, Fernandes, JC, Fischer, F, Fitchett, JR, Foigt, N, Fullman, N, Fürst, T, Gankpé, FG, Gebre, T, Gebremedhin, AT, Gebru, AA, Geleijnse, JM, Gessner, BD, Gething, PW, Ghiwot, TT, Giroud, M, Gishu, MD, Glaser, E, Goenka, S, Goodridge, A, Gopalani, SV, Goto, A, Gugnani, HC, Guimaraes, MD, Gupta, R, Gupta, V, Haagsma, J, Hafezi-Nejad, N, Hagan, H, Hailu, GB, Hamadeh, RR, Hamidi, S, Hammami, M, Hankey, GJ, Hao, Y, Harb, HL, Harikrishnan, S, Haro, JM, Harun, KM, Havmoeller, R, Hedayati, MT, Heredia-Pi, IB, Hoek, HW, Horino, M, Horita, N, Hosgood, HD, Hoy, DG, Hsairi, M, Hu, G, Huang, H, Huang, JJ, Iburg, KM, Idrisov, BT, Innos, K, Iyer, VJ, Jacobsen, KH, Jahanmehr, N, Jakovljevic, MB, Javanbakht, M, Jayatilleke, AU, Jeemon, P, Jha, V, Jiang, G, Jiang, Y, Jibat, T, Jonas, JB, Kabir, Z, Kamal, R, Kan, H, Karch, A, Karema, CK, Karletsos, D, Kasaeian, A, Kaul, A, Kawakami, N, Kayibanda, JF, Keiyoro, PN, Kemp, AH, Kengne, AP, Kesavachandran, CN, Khader, YS, Khalil, I, Khan, AR, Khan, EA, Khang, YH, Khubchandani, J, Kim, YJ, Kinfu, Y, Kivipelto, M, Kokubo, Y, Kosen, S, Koul, PA, Koyanagi, A, Defo, BK, Bicer, BK, Kulkarni, VS, Kumar, GA, Lal, DK, Lam, H, Lam, JO, Langan, SM, Lansingh, VC, Larsson, A, Leigh, J, Leung, R, Li, Y, Lim, SS, Lipshultz, SE, Liu, S, Lloyd, BK, Logroscino, G, Lotufo, PA, Lunevicius, R, Razek, HM, Mahdavi, M, Majdan, M, Majeed, A, Makhlouf, C, Malekzadeh, R, Mapoma, CC, Marcenes, W, Martinez-Raga, J, Marzan, MB, Masiye, F, Mason-Jones, AJ, Mayosi, BM, McKee, M, Meaney, PA, Mehndiratta, MM, Mekonnen, AB, Melaku, YA, Memiah, P, Memish, ZA, Mendoza, W, Meretoja, A, Meretoja, TJ, Mhimbira, FA, Miller, TR, Mikesell, J, Mirarefin, M, Mohammad, KA, Mohammed, S, Mokdad, AH, Monasta, L, Moradi-Lakeh, M, Mori, R, Mueller, UO, Murimira, B, Murthy, GV, Naheed, A, Naldi, L, Nangia, V, Nash, D, Nawaz, H, Nejjari, C, Ngalesoni, FN, De Dieu Ngirabega, J, Nguyen, QL, Nisar, MI, Norheim, OF, Norman, RE, Nyakarahuka, L, Ogbo, FA, Oh, IH, Ojelabi, FA, Olusanya, BO, Olusanya, JO, Opio, JN, Oren, E, Ota, E, Padukudru, MA, Park, HY, Park, JH, Patil, ST, Patten, SB, Paul, VK, Pearson, K, Peprah, EK, Pereira, CC, Perico, N, Pesudovs, K, Petzold, M, Phillips, MR, Pillay, JD, Plass, D, Polinder, S, Pourmalek, F, Prokop, DM, Qorbani, M, Rafay, A, Rahimi, K, Rahimi-Movaghar, V, Rahman, M, Rahman, MH, Rahman, SU, Rai, RK, Rajsic, S, Ram, U, Rana, SM, Rao, PV, Remuzzi, G, Rojas-Rueda, D, Ronfani, L, Roshandel, G, Roy, A, Ruhago, GM, Saeedi, MY, Sagar, R, Saleh, MM, Sanabria, JR, Santos, IS, Sarmiento-Suarez, R, Sartorius, B, Sawhney, M, Schutte, AE, Schwebel, DC, Seedat, S, Sepanlou, SG, Servan-Mori, EE, Shaikh, MA, Sharma, R, She, J, Sheikhbahaei, S, Shen, J, Shibuya, K, Shin, HH, Sigfusdottir, ID, Silpakit, N, Silva, DA, Silveira, DG, Simard, EP, Sindi, S, Singh, JA, Singh, OP, Singh, PK, Skirbekk, V, Sliwa, K, Soneji, S, Sorensen, RJ, Soriano, JB, Soti, DO, Sreeramareddy, CT, Stathopoulou, V, Steel, N, Sunguya, BF, Swaminathan, S, Sykes, BL, Tabarés-Seisdedos, R, Talongwa, RT, Tavakkoli, M, Taye, B, Tedla, BA, Tekle, T, Shifa, GT, Temesgen, AM, Terkawi, AS, Tesfay, FH, Tessema, GA, Thapa, K, Thomson, AJ, Thorne-Lyman, AL, Tobe-Gai, R, Topor-Madry, R, Towbin, JA, Tran, BX, Dimbuene, ZT, Tsilimparis, N, Tura, AK, Ukwaja, KN, Uneke, CJ, Uthman, OA, Venketasubramanian, N, Vladimirov, SK, Vlassov, VV, Vollset, SE, Wang, L, Weiderpass, E, Weintraub, RG, Werdecker, A, Westerman, R, Wijeratne, T, Wilkinson, JD, Wiysonge, CS, Wolfe, CD, Won, S, Wong, JQ, Xu, G, Yadav, AK, Yakob, B, Yalew, AZ, Yano, Y, Yaseri, M, Yebyo, HG, Yip, P, Yonemoto, N, Yoon, SJ, Younis, MZ, Yu, C, Yu, S, Zaidi, Z, Zaki, MELS, Zeeb, H, Zhang, H, Zhao, Y, Zodpey, S, Zoeckler, L, Zuhlke, LJ, Lopez, AD, and Murray, CJ

Subjects
GBD 2015 HIV Collaborators
Abstract

BACKGROUND: Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015. METHODS: For countries without high-quality vital registration data, we estimated prevalence and incidence with data from antenatal care clinics and population-based seroprevalence surveys, and with assumptions by age and sex on initial CD4 distribution at infection, CD4 progression rates (probability of progression from higher to lower CD4 cell-count category), on and off antiretroviral therapy (ART) mortality, and mortality from all other causes. Our estimation strategy links the GBD 2015 assessment of all-cause mortality and estimation of incidence and prevalence so that for each draw from the uncertainty distribution all assumptions used in each step are internally consistent. We estimated incidence, prevalence, and death with GBD versions of the Estimation and Projection Package (EPP) and Spectrum software originally developed by the Joint United Nations Programme on HIV/AIDS (UNAIDS). We used an open-source version of EPP and recoded Spectrum for speed, and used updated assumptions from systematic reviews of the literature and GBD demographic data. For countries with high-quality vital registration data, we developed the cohort incidence bias adjustment model to estimate HIV incidence and prevalence largely from the number of deaths caused by HIV recorded in cause-of-death statistics. We corrected these statistics for garbage coding and HIV misclassification. FINDINGS: Global HIV incidence reached its peak in 1997, at 3·3 million new infections (95% uncertainty interval [UI] 3·1-3·4 million). Annual incidence has stayed relatively constant at about 2·6 million per year (range 2·5-2·8 million) since 2005, after a period of fast decline between 1997 and 2005. The number of people living with HIV/AIDS has been steadily increasing and reached 38·8 million (95% UI 37·6-40·4 million) in 2015. At the same time, HIV/AIDS mortality has been declining at a steady pace, from a peak of 1·8 million deaths (95% UI 1·7-1·9 million) in 2005, to 1·2 million deaths (1·1-1·3 million) in 2015. We recorded substantial heterogeneity in the levels and trends of HIV/AIDS across countries. Although many countries have experienced decreases in HIV/AIDS mortality and in annual new infections, other countries have had slowdowns or increases in rates of change in annual new infections. INTERPRETATION: Scale-up of ART and prevention of mother-to-child transmission has been one of the great successes of global health in the past two decades. However, in the past decade, progress in reducing new infections has been slow, development assistance for health devoted to HIV has stagnated, and resources for health in low-income countries have grown slowly. Achievement of the new ambitious goals for HIV enshrined in Sustainable Development Goal 3 and the 90-90-90 UNAIDS targets will be challenging, and will need continued efforts from governments and international agencies in the next 15 years to end AIDS by 2030. Funding: We thank the countless individuals who have contributed to the Global Burden of Disease (GBD) Study 2015 in various capacities. We specifically thank Jeffrey Eaton and John Stover. HW and CJLM received funding for this study from the Bill & Melinda Gates Foundation; the National Institute of Mental Health, National Institutes of Health (NIH; R01MH110163); and the National Institute on Aging, NIH (P30AG047845). LJAR acknowledges the support of Qatar National Research Fund (NPRP 04-924-3-251) who provided the main funding for generating the data provided to the GBD-Institute for Health Metrics and Evaluation effort. BPAQ acknowledges institutional support from PRONABEC (National Program of Scholarship and Educational Loan), provided by the Peruvian government. DB is supported by the Bill & Melinda Gates Foundation (grant number OPP1068048). JDN was supported in his contribution to this work by a Fellowship from Fundacao para a Ciencia e a Tecnologia, Portugal (SFRH/BPD/92934/2013). KD is supported by a Wellcome Trust Fellowship in Public Health and Tropical Medicine (grant number 099876). TF received financial support from the Swiss National Science Foundation (SNSF; project number P300P3-154634). AG acknowledges funding from Sistema Nacional de Investigadores de Panama-SNI. PJ is supported by Wellcome Trust-DBT India Alliance Clinical and Public Health Intermediate Fellowship. MK receives research support from the Academy of Finland, the Swedish Research Council, Alzheimerfonden, Alzheimer's Research & Prevention Foundation, Center for Innovative Medicine (CIMED) at Karolinska Institutet South Campus, AXA Research Fund, Wallenberg Clinical Scholars Award from the Knut och Alice Wallenbergs Foundation, and the Sheika Salama Bint Hamdan Al Nahyan Foundation. AK's work was supported by the Miguel Servet contract financed by the CP13/00150 and PI15/00862 projects, integrated into the National R&D&I and funded by the ISCIII (General Branch Evaluation and Promotion of Health Research), and the European Regional Development Fund (ERDF-FEDER). SML is funded by a National Institute for Health Research (NIHR) Clinician Scientist Fellowship (grant number NIHR/CS/010/014). HJL reports grants from the NIHR, EU Innovative Medicines Initiative, Centre for Strategic & International Studies, and WHO. WM is Program analyst, Population and Development, in the Peru Country Office of the United Nations Population Fund, which does not necessarily endorse this study. For UOM, funding from the German National Cohort Consortium (O1ER1511D) is gratefully acknowledged. KR reports grants from NIHR Oxford Biomedical Research Centre, NIHR Career Development Fellowship, and Oxford Martin School during the conduct of the study. GR acknowledges that work related to this paper has been done on the behalf of the GBD Genitourinary Disease Expert Group supported by the International Society of Nephrology (ISN). ISS reports grants from FAPESP (Brazilian public agency). RSS receives institutional support from Universidad de Ciencias Aplicadas y Ambientales, UDCA, Bogota Colombia. SS receives postdoctoral funding from the Fonds de la recherche en sante du Quebec (FRSQ), including its renewal. RTS was supported in part by grant number PROMETEOII/2015/021 from Generalitat Valenciana and the national grant PI14/00894 from ISCIII-FEDER. PY acknowledges support from Strategic Public Policy Research (HKU7003-SPPR-12).

Published
2016

207. Severe Polycystic Liver Disease Is Not Caused by Large Deletions of the PRKCSH Gene

Author

Cnossen, W.R., Maurits, J.S., Salomon, J., Morsche, R.H. te, Waanders, E., and Drenth, J.P.H.

Subjects
Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14]
Abstract

Item does not contain fulltext BACKGROUND: Isolated polycystic liver disease (ADPLD) is an autosomal dominant Mendelian disorder. Heterozygous PRKCSH (where PRKCSH is protein kinase C substrate 80K-H (80 kDa protein, heavy chain; MIM*177060) mutations are the most frequent cause. Routine molecular testing using Sanger sequencing identifies pathogenic variants in the PRKCSH (15%) and SEC63 (where SEC63 is Saccharomyces cerevisiae homolog 63 (MIM*608648); 6%) genes, but about approximately 80% of patients meeting the clinical ADPLD criteria carry no PRKCSH or SEC63 mutation. Cyst tissue often shows somatic deletions with loss of heterozygosity that was recently recognized as a general mechanism in ADPLD. We hypothesized that germline deletions in the PRKCSH gene may be responsible for hepatic cystogenesis in a significant number of mutation-negative ADPLD patients. METHODS: In this study, we designed a multiplex ligation-dependent probe amplification (MLPA) assay to screen for deletions of PRKCSH exons. Genomic DNA from 60 patients with an ADPLD phenotype was included. RESULTS: MLPA analysis detected no exon deletions in mutation-negative ADPLD patients. CONCLUSION: Large copy number variations on germline level are not present in patients with a clinical diagnosis of ADPLD. MLPA analysis of the PRKCSH gene should not be considered as a diagnostic method to explain hepatic cystogenesis.

Published
2016

209. From invasion percolation to flow in rock fracture networks

Author

Nuno A. M. Araújo, Hans J. Herrmann, Salomon J. Wettstein, Falk K. Wittel, and Bill Lanyon

Subjects
Statistics and Probability, Condensed Matter - Materials Science, Statistical Mechanics (cond-mat.stat-mech), General distribution, Fluid Dynamics (physics.flu-dyn), Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, Physics - Fluid Dynamics, Mechanics, Computational Physics (physics.comp-ph), Condensed Matter Physics, Geophysics (physics.geo-ph), Physics - Geophysics, Permeability (earth sciences), Path length, Fracture (geology), Two-phase flow, Invasion percolation, Anisotropy, Saturation (chemistry), Physics - Computational Physics, Condensed Matter - Statistical Mechanics, Geology
Abstract

The main purpose of this work is to simulate two-phase flow in the form of immiscible displacement through anisotropic, three-dimensional (3D) discrete fracture networks (DFN). The considered DFNs are artificially generated, based on a general distribution function or are conditioned on measured data from deep geological investigations. We introduce several modifications to the invasion percolation (MIP) to incorporate fracture inclinations, intersection lines, as well as the hydraulic path length inside the fractures. Additionally a trapping algorithm is implemented that forbids any advance of the invading fluid into a region, where the defending fluid is completely encircled by the invader and has no escape route. We study invasion, saturation, and flow through artificial fracture networks, with varying anisotropy and size and finally compare our findings to well studied, conditioned fracture networks., 18 pages, 10 figures

Published
2012

210. Modern gold deportments and its application to industry

Author

Louis L. Coetzee, Juan-David van der Merwe, Gavin J. Martin, Tracey A. Stanek, and Salomon J. Theron

Subjects
Gold cyanidation, business.industry, Mechanical Engineering, QEMSCAN, Metallurgy, General Chemistry, engineering.material, Geotechnical Engineering and Engineering Geology, Characterization (materials science), Control and Systems Engineering, engineering, Marcasite, Gangue, Process optimization, Process engineering, business, Pyrrhotite, Gravity separation
Abstract

Modern gold deportment studies include physical, chemical and mineralogical assessments, combined to obtain a full understanding of the nature and variability of gold in a resource. The objective is to provide information which will allow cost effective and practical processing by informing decisions regarding resource evaluation, mining method and extraction process optimization. The distribution of gold, based on speciation, grain size and mode of occurrence (liberation, exposure, and mineral association) is quantitatively determined by means of automated Scanning Electron Microscopic Techniques (QEMSCAN/MLA). Furthermore, general mineralogical characterization is undertaken in order to characterize the gangue components; with special emphasis on deleterious characteristics of the ore (e.g. cyanide consumers such as secondary Cu-species, preg-robbers/borrowers, passivation due to Sb-minerals or As-minerals and oxygen consumers such as pyrrhotite/marcasite). Predictions based on the mineralogical observations are confirmed by physical and chemical testwork. These include grading analyses, gravity separation, direct cyanidation, and diagnostic (sequential) leach tests.

Published
2011

220. Is faecal microbiota transplantation an option to eradicate highly drug-resistant enteric bacteria carriage?

Author

Davido, B., primary, Batista, R., additional, Michelon, H., additional, Lepainteur, M., additional, Bouchand, F., additional, Lepeule, R., additional, Salomon, J., additional, Vittecoq, D., additional, Duran, C., additional, Escaut, L., additional, Sobhani, I., additional, Paul, M., additional, Lawrence, C., additional, Perronne, C., additional, Chast, F., additional, and Dinh, A., additional

Published
2017
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221. Implementation of a simple innovative system for postprescription antibiotic review based on computerized tools with shared access

Author

Bouchand, F., primary, Dinh, A., additional, Roux, A.L., additional, Davido, B., additional, Michelon, H., additional, Lepainteur, M., additional, Legendre, B., additional, El Sayed, F., additional, Pierre, I., additional, Salomon, J., additional, Lawrence, C., additional, Perronne, C., additional, Villart, M., additional, and Crémieux, A-C., additional

Published
2017
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224. Cricket and the Liberalist World-View

Author

Salomon J. Terreblanche

Subjects
Cultural Studies, Naivety, biology, media_common.quotation_subject, biology.organism_classification, Epistemology, Liberalism, Cricket, Law, Product (category theory), Sociology, Ideology, World view, media_common
Abstract

A philosophical study of the link between sport and culture, this essay investigates the extent to which the structure of cricket can be seen as a product of the liberalist world-view. Nineteenth-century Britain was the cradle of both cricket and liberalism. It should not be surprising if this aspect of British culture has influenced the evolution of cricket to the extent that the modern game embodies the ideological frame of mind of its birthplace. Dealing explicitly with the constitutive, rule-bound aspects of cricket, three formal aspects in particular are discussed: first, the toss as a necessary condition of equality of opportunity in cricket matches, secondly the role of the umpire as a bounded authority within the game and thirdly, the interplay of individual and collective interest. With regard to the history of cricket it is argued that an evolution from Lockean to Smithean liberalism can be noted. In the naivety of nineteenth-century (Lockean) liberalism, in which the game was founded, cricket p...

Published
2007

226. Accurate stellar masses for SB2 components: Interferometric observations for Gaia validation

Author

Halbwachs, J. -L, Boffin, H. M. J., Le Bouquin, J. -B, Famaey, B., Salomon, J. -B, Frédéric Arenou, Pourbaix, D., Anthonioz, F., Grellmann, R., Guieu, S., Guillout, P., Jorissen, A., Kiefer, F., Lebreton, Y., Mazeh, T., Nebot Gómez-Morán, A., Sana, H., Tal-Or, L., Observatoire astronomique de Strasbourg (ObAS), Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Université Libre de Bruxelles [Bruxelles] (ULB), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), University of Amsterdam [Amsterdam] (UvA), F. Martins, S. Boissier, V. Buat, L. Cambrésy, P. Petit, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG ), Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université libre de Bruxelles (ULB), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Lebreton, Yveline, and F. Martins, S. Boissier, V. Buat, L. Cambrésy, P. Petit

Subjects
[SDU] Sciences of the Universe [physics], [PHYS]Physics [physics], [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], [SDU]Sciences of the Universe [physics], [SDU.ASTR] Sciences of the Universe [physics]/Astrophysics [astro-ph], ComputingMilieux_MISCELLANEOUS, [PHYS] Physics [physics]
Abstract

National audience

Published
2015

227. Funktionelle Untersuchungen humaner primärer nasaler Epithelzellen von Patienten mit chronischer Rhinosinusitis

Author

Albrecht, T, Salomon, J, Baumann, I, and Mall, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die chronische Rhinosinusitis (CRS) ist eine der häufigsten chronischen Erkrankungen mit wesentlicher Auswirkung auf die Lebensqualität der Patienten. Die CRS ist ein äußerst heterogenes Krankheitsbild, dessen zugrunde liegenden pathophysiologischen Mechanismen noch nicht eindeutig identifiziert sind. Dabei spielt sicher die nasale Epithelbarriere eine wichtige Rolle bei der Regulierung der Homöostase. Das Ziel dieser Studie ist es, epitheliale Chloridströme von Patienten mit chronischer Sinusitis funktionell zu untersuchen. Methoden: Polypöses Gewebe wurde während eines Nasennebenhöhleneingriffs gewonnen und primäre nasale Epithelzellen (hNEpC) wurden isoliert und für 14 Tage auf Costar Snapwell-Filtern kultiviert. Die Funktionalität des Gewebes wurde in Ussing Kammern Messungen gemessen. Ergebnisse: Die transepithelialen Widerstandswerte (TEER) der hNEpC-Zellmonolayer betrugen zwischen 250–900 Ω/cm2. Bioelektrische Messungen wurden anhand eines von basolateral-zu-apikal angelegten Chloridgradienten etabliert. Unter diesen Bedingungen konnte der basale Kurzschlussstrom (Isc) durch die Gabe von IBMX/FSK signifikant stimuliert werden. Die Gabe von Chloridkanalinhibitoren wie CFTRinh führte zur Reduktion der cAMP (IBMX/FSK)-stimulierten Chloridsekretion. Differenzen in der Chloridleitfähigkeit von Nasengewebe aus unterschiedlichen Regionen wurden festgestellt. Schlussfolgerung: Ussing Kammer Messungen am Nasenepithel von Patienten mit chronischer Rhinosinusitis sind eine vielversprechende Methode zur weiteren Untersuchung des zugrunde liegenden Pathomechanismus und einer möglichen Korrelation mit dem Krankheitsbild. Der Erstautor gibt keinen Interessenkonflikt an., GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery; 11:Doc381; ISSN 1865-1038

Published
2015
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228. MLST reveals potentially high-risk international clones of Enterobacter cloacae

Author

Izdebski, R. Baraniak, A. Herda, M. Fiett, J. Bonten, M.J.M. Carmeli, Y. Goossens, H. Hryniewicz, W. Brun-buisson, C. Gniadkowski, M. Grabowska, A. Nikonorow, E. Derde, L.P.G. Dautzenberg, M.J. Adler, A. Kazma, M. Navon-venezia, S. Malhotra-kumar, S. Lammens, C. Dumpis, U. Giamarellou, H. Muzlovic, I. Nardi, G. Petrikkos, G.L. Stammet, P. Salomon, J. Lawrence, C. Legrand, P. Rossini, A. Salvia, A. Samso, J.V. Fierro, J. Paul, M. Lerman, Y. MOSAR WP2, WP3 WP5 study groups

Subjects
bacterial infections and mycoses
Abstract

Objectives: To perform the first multinational Enterobacter cloacae clonality study, using the MLST scheme newly developed in Japan. Methods: The analysis included 195 rectal carriage E. cloacae isolates resistant to expanded-spectrum cephalosporins (ESCs), collected from patients in 12 hospital units across Europe and Israel. All of the isolates were typed by PFGE and 173 isolates were subjected to MLST. ESC resistance was analysed phenotypically; genes encoding ESBLs and carbapenemases were identified by PCR and sequencing. Results: MLST distinguished 88 STs, which correlated with the PFGE data. PFGE was more discriminatory, producing 129 pulsotypes (169 patterns). Numerous STs were observed in several countries each. The most widespread were ST66, ST78, ST108 and ST114, each having at least 10 isolates from three to five countries, diversified into multiple pulsotypes, with clusters of related isolates in one or more centres. Analysis of the STs against the MLST database revealed several epidemic clonal complexes, such as those with central genotypes ST74 (including ST78) or ST114 (including ST66). ESC resistance was equally related to overexpression of the AmpC cephalosporinase and to ESBL production. Among ESBL producers some spreading subclones were identified, including specific ST66, ST78 and ST114 pulsotypes, associated with CTX-M-15 production. Several isolates produced carbapenemase VIM-1 or KPC-2. Conclusions: Together with the information available in the MLST database, our results suggest that, like Escherichia coli and Klebsiella pneumoniae, E. cloacae harbours clonal lineages of increased epidemic potential that may be associated with resistance spread. © The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.

Published
2015

229. Phylogenetic lineages, clones and β-lactamases in an international collection of Klebsiella oxytoca isolates non-susceptible to expanded-spectrum cephalosporins

Author

Izdebski, R. Fiett, J. Urbanowicz, P. Baraniak, A. Derde, L.P.G. Bonten, M.J.M. Carmeli, Y. Goossens, H. Hryniewicz, W. Brun-Buisson, C. Brisse, S. Gniadkowski, M. Herda, M. Dautzenberg, M.J. Adler, A. Kazma, M. Navon-Venezia, S. Malhotra-Kumar, S. Lammens, C. Legrand, P. Chalfine, A. Giamarellou, H. Petrikkos, G.L. Balode, A. Dumpis, U. Stammet, P. Aragăo, I. Esteves, F. Torres Martí, A. Lawrence, C. Salomon, J. Paul, M. Lerman, Y. Rossini, A. Salvia, A. Vidal Samso, J. Fierro, J. MOSAR WP2, WP3 WP5 Study Groups

Subjects
biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses
Abstract

Objectives: The objective of this study was to examine Klebsiella oxytoca clonal and phylogenetic diversity, based on an international collection of carriage isolates non-susceptible to expanded-spectrum cephalosporins (ESCs). Methods: The study material comprised 68 rectal carriage K. oxytoca isolates non-susceptible to ESCs recovered in 2008-11 from patients in 14 hospitals across Europe and Israel. ESC resistance was tested phenotypically; genes encoding ESBLs, AmpC cephalosporinases and carbapenemases were amplified and sequenced. The isolates were typed by PFGE and MLST, followed by sequencing of blaOXY genes. Results: MLSTand PFGE distinguished 34 STs and 47 pulsotypes among the isolates, respectively. Six STswere split into several pulsotypes each. Five STs were more prevalent (n=2-9) and occurred in several countries each, including ST2, ST9 and ST141, which belong to a growing international clonal complex (CC), CC2. Four phylogenetic lineages were distinguished, each with another type of chromosomal OXY-type β-lactamase. Three of these, with OXY-1/-5, OXY-2 types and OXY-4, corresponded to previously described phylogroups KoI, KoII and KoIV, respectively. A single isolate from Israel represented a distinct lineage with a newly defined OXY-7 type. The phylogroups showed interesting differences in mechanisms of ESC resistance; KoI strains rarely overexpressed the OXY enzymes but commonly produced ESBLs, whereas KoII strains often were OXY hyperproducers and carried ESBLs much less frequently. AmpCs (DHA-1) and carbapenemases (VIM-1) occurred sporadically. Conclusions: The study confirmed the high genetic diversity of the collection of K. oxytoca ESC-non-susceptible isolates, composed of phylogroups with distinct types of OXY-type β-lactamases, and revealed some STs of broad geographical distribution.

Published
2015

230. Survey of metallo-β-lactamase-producing Enterobacteriaceae colonizing patients in European ICUs and rehabilitation units, 2008-11

Author

Papagiannitsis, C.C. Izdebski, R. Baraniak, A. Fiett, J. Herda, M. Hrabák, J. Derde, L.P.G. Bonten, M.J.M. Carmeli, Y. Goossens, H. Hryniewicz, W. Brun-Buisson, C. Gniadkowski, M. Grabowska, A. Nikonorow, E. Dautzenberg, M.J. Adler, A. Kazma, M. Navon-Venezia, S. Malhotra-Kumar, S. Lammens, C. Legrand, P. Annane, D. Chalfine, A. Joseph, S. Giamarellou, H. Petrikkos, G.L. Nardi, G. Balode, A. Dumpis, U. Stammet, P. Aragâo, I. Esteves, F. Muzlovic, I. Tomic, V. Martí, A.T. Lawrence, C. Salomon, J. Paul, M. Lerman, Y. Rossini, A. Salvia, A. Samso, J.V. Fierro, J. MOSAR WP2, WP3 WP5 study groups

Subjects
biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses
Abstract

Objectives: The objective of this study was to perform a multinational survey of patients' colonization by metallo-β-lactamase (MBL)-producing Enterobacteriaceae, including their molecular characterization. Methods: Patients in 18 hospital units across Europe and Israel (n = 17 945) were screened between mid-2008 and mid-2011. MBL-producing isolates were typed by PFGE and MLST. MBL genes were amplified and sequenced within their integrons. Plasmids with MBL genes were analysed by nuclease S1 plus hybridization profiling, mating and transformation assays, and by PCR-based replicon typing. Results: Ninety-one patients in nine centres (six countries), including 62 patients in two Greek ICUs, carried 94 non-duplicate MBL-producing organisms. Klebsiella pneumoniae isolates from Greece dominated (n = 57) and belonged mainly to ST147, ST36 and ST383. All but one of the isolates expressed VIM-1-type MBLs. Isolates of Greek origins produced five enzymes, including new VIM-39, encoded by class 1 integrons of four types. In-e541-like elements prevailed, comprising six variants located on IncR, IncFIIK, IncR + FIIK, IncR + A/C or non-typeable plasmids. The other group were new In4873 and In4863, being the first In416-like elements identified in Greece, which were present on IncA/C or non-typeable plasmids. Isolates from other countries produced only VIM-1 and the major integron was In916, identified in 16 organisms from France, Italy and Spain. In916 was carried by four plasmid types, including IncA/C, IncFIIK and IncHI2. Other integrons included a new element, In3103, in Spain and In110 identified only in Latvia. Conclusions: This study provided fully comparable data on the occurrence and molecular characteristics of VIM-producing Enterobacteriaceae in a group of hospital units across Europe, documenting recent changes in their epidemiology. © The Author 2015. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.

Published
2015

231. CCDC115 Deficiency Causes a Disorder of Golgi Homeostasis with Abnormal Protein Glycosylation

Author

Jansen, J.C., Cirak, S., Scherpenzeel, M. van, Timal, S., Reunert, J., Rust, S., Perez, B., Vicogne, D., Krawitz, P., Wada, Y., Ashikov, A.M., Perez-Cerda, C., Medrano, C., Arnoldy, A., Hoischen, A., Huijben, K., Steenbergen, G., Quelhas, D., Diogo, L., Rymen, D., Jaeken, J., Guffon, N., Cheillan, D., Heuvel, B. van den, Maeda, Y., Kaiser, O., Schara, U., Gerner, P., Boogert, M.A. van den, Holleboom, A.G., Nassogne, M.C., Sokal, E., Salomon, J., Bogaart, G. van den, Drenth, J.P., Huynen, M.A., Veltman, J.A., Wevers, R.A., Morava, E., Matthijs, G., Foulquier, F., Marquardt, T., Lefeber, D.J., Jansen, J.C., Cirak, S., Scherpenzeel, M. van, Timal, S., Reunert, J., Rust, S., Perez, B., Vicogne, D., Krawitz, P., Wada, Y., Ashikov, A.M., Perez-Cerda, C., Medrano, C., Arnoldy, A., Hoischen, A., Huijben, K., Steenbergen, G., Quelhas, D., Diogo, L., Rymen, D., Jaeken, J., Guffon, N., Cheillan, D., Heuvel, B. van den, Maeda, Y., Kaiser, O., Schara, U., Gerner, P., Boogert, M.A. van den, Holleboom, A.G., Nassogne, M.C., Sokal, E., Salomon, J., Bogaart, G. van den, Drenth, J.P., Huynen, M.A., Veltman, J.A., Wevers, R.A., Morava, E., Matthijs, G., Foulquier, F., Marquardt, T., and Lefeber, D.J.

Abstract

Contains fulltext : 167630.pdf (publisher's version ) (Closed access), Disorders of Golgi homeostasis form an emerging group of genetic defects. The highly heterogeneous clinical spectrum is not explained by our current understanding of the underlying cell-biological processes in the Golgi. Therefore, uncovering genetic defects and annotating gene function are challenging. Exome sequencing in a family with three siblings affected by abnormal Golgi glycosylation revealed a homozygous missense mutation, c.92T>C (p.Leu31Ser), in coiled-coil domain containing 115 (CCDC115), the function of which is unknown. The same mutation was identified in three unrelated families, and in one family it was compound heterozygous in combination with a heterozygous deletion of CCDC115. An additional homozygous missense mutation, c.31G>T (p.Asp11Tyr), was found in a family with two affected siblings. All individuals displayed a storage-disease-like phenotype involving hepatosplenomegaly, which regressed with age, highly elevated bone-derived alkaline phosphatase, elevated aminotransferases, and elevated cholesterol, in combination with abnormal copper metabolism and neurological symptoms. Two individuals died of liver failure, and one individual was successfully treated by liver transplantation. Abnormal N- and mucin type O-glycosylation was found on serum proteins, and reduced metabolic labeling of sialic acids was found in fibroblasts, which was restored after complementation with wild-type CCDC115. PSI-BLAST homology detection revealed reciprocal homology with Vma22p, the yeast V-ATPase assembly factor located in the endoplasmic reticulum (ER). Human CCDC115 mainly localized to the ERGIC and to COPI vesicles, but not to the ER. These data, in combination with the phenotypic spectrum, which is distinct from that associated with defects in V-ATPase core subunits, suggest a more general role for CCDC115 in Golgi trafficking. Our study reveals CCDC115 deficiency as a disorder of Golgi homeostasis that can be readily identified via screening for abnormal glyc

Published
2016

232. Chromosomal abnormalities in hepatic cysts point to novel polycystic liver disease genes

Author

Wills, E.S., Cnossen, W.R., Veltman, J.A., Woestenenk, R.M., Steehouwer, M., Salomon, J., Morsche, R.H.M. te, Huch, M., Hehir-Kwa, J.Y., Banning, M.J., Pfundt, R.P., Roepman, R., Hoischen, A., Drenth, J.P.H., Wills, E.S., Cnossen, W.R., Veltman, J.A., Woestenenk, R.M., Steehouwer, M., Salomon, J., Morsche, R.H.M. te, Huch, M., Hehir-Kwa, J.Y., Banning, M.J., Pfundt, R.P., Roepman, R., Hoischen, A., and Drenth, J.P.H.

Abstract

Contains fulltext : 167652.pdf (publisher's version ) (Closed access), Autosomal dominant polycystic liver disease (ADPLD) is caused by variants in PRKCSH, SEC63, and LRP5, whereas autosomal dominant polycystic kidney disease is caused by variants in PKD1 and PKD2. Liver cyst development in these disorders is explained by somatic loss-of-heterozygosity (LOH) of the wild-type allele in the developing cyst. We hypothesize that we can use this mechanism to identify novel disease genes that reside in LOH regions. In this study, we aim to map abnormal genomic regions using high-density SNP microarrays to find novel PLD genes. We collected 46 cysts from 23 patients with polycystic or sporadic hepatic cysts, and analyzed DNA from those cysts using high-resolution microarray (n=24) or Sanger sequencing (n=22). We here focused on regions of homozygosity on the autosomes (>3.0 Mb) and large CNVs (>1.0 Mb). We found frequent LOH in PRKCSH (22/29) and PKD1/PKD2 (2/3) cysts of patients with known heterozygous germline variants in the respective genes. In the total cohort, 12/23 patients harbored abnormalities outside of familiar areas. In individual ADPLD cases, we identified germline events: a 2q13 complex rearrangement resulting in BUB1 haploinsufficiency, a 47XXX karyotype, chromosome 9q copy-number loss, and LOH on chromosome 3p. The latter region was overlapping with an LOH region identified in two other cysts. Unique germline and somatic abnormalities occur frequently in and outside of known genes underlying cysts. Each liver cyst has a unique genetic makeup. LOH driver gene BUB1 may imply germline causes of genetic instability in PLD.

Published
2016

233. TMEM199 Deficiency Is a Disorder of Golgi Homeostasis Characterized by Elevated Aminotransferases, Alkaline Phosphatase, and Cholesterol and Abnormal Glycosylation

Author

Jansen, J.C., Timal, S., Scherpenzeel, M. van, Michelakakis, H., Vicogne, D., Ashikov, A.M., Moraitou, M., Hoischen, A., Huijben, K., Steenbergen, G.C., Boogert, M.A.W. van den, Porta, F., Calvo, P.L., Mavrikou, M., Cenacchi, G., Bogaart, G. van den, Salomon, J., Holleboom, A.G., Rodenburg, R.J., Drenth, J.P., Huynen, M.A., Wevers, R.A., Morava, E., Foulquier, F., Veltman, J.A., Lefeber, D.J., Jansen, J.C., Timal, S., Scherpenzeel, M. van, Michelakakis, H., Vicogne, D., Ashikov, A.M., Moraitou, M., Hoischen, A., Huijben, K., Steenbergen, G.C., Boogert, M.A.W. van den, Porta, F., Calvo, P.L., Mavrikou, M., Cenacchi, G., Bogaart, G. van den, Salomon, J., Holleboom, A.G., Rodenburg, R.J., Drenth, J.P., Huynen, M.A., Wevers, R.A., Morava, E., Foulquier, F., Veltman, J.A., and Lefeber, D.J.

Abstract

Contains fulltext : 168169.pdf (publisher's version ) (Closed access), Congenital disorders of glycosylation (CDGs) form a genetically and clinically heterogeneous group of diseases with aberrant protein glycosylation as a hallmark. A subgroup of CDGs can be attributed to disturbed Golgi homeostasis. However, identification of pathogenic variants is seriously complicated by the large number of proteins involved. As part of a strategy to identify human homologs of yeast proteins that are known to be involved in Golgi homeostasis, we identified uncharacterized transmembrane protein 199 (TMEM199, previously called C17orf32) as a human homolog of yeast V-ATPase assembly factor Vph2p (also known as Vma12p). Subsequently, we analyzed raw exome-sequencing data from families affected by genetically unsolved CDGs and identified four individuals with different mutations in TMEM199. The adolescent individuals presented with a mild phenotype of hepatic steatosis, elevated aminotransferases and alkaline phosphatase, and hypercholesterolemia, as well as low serum ceruloplasmin. Affected individuals showed abnormal N- and mucin-type O-glycosylation, and mass spectrometry indicated reduced incorporation of galactose and sialic acid, as seen in other Golgi homeostasis defects. Metabolic labeling of sialic acids in fibroblasts confirmed deficient Golgi glycosylation, which was restored by lentiviral transduction with wild-type TMEM199. V5-tagged TMEM199 localized with ERGIC and COPI markers in HeLa cells, and electron microscopy of a liver biopsy showed dilated organelles suggestive of the endoplasmic reticulum and Golgi apparatus. In conclusion, we have identified TMEM199 as a protein involved in Golgi homeostasis and show that TMEM199 deficiency results in a hepatic phenotype with abnormal glycosylation.

Published
2016

234. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015

Author

Wang, H, Wolock, TM, Carter, A, Nguyen, G, Kyu, HH, Gakidou, E, Hay, SI, Msemburi, W, Coates, MM, Mooney, MD, Fraser, MS, Sligar, A, Larson, HJ, Friedman, J, Brown, A, Dandona, L, Fullman, N, Haagsma, J, Khalil, I, Lim, SS, Mikesell, J, Mokdad, AH, Moradi-Lakeh, M, Pearson, K, Silpakit, B, Sorensen, MJD, Temesgen, AM, Vollset, SE, Zoeckler, L, Murray, CJL, Alfonso-Cristancho, R, Harun, KM, Prokop, DM, Mills, EJ, Trickey, A, Ajala, ON, Bärnighausen, T, Ding, EL, Farvid, MS, Thorne-Lyman, AL, Won, S, Fitchett, JRA, Salomon, J, Abajobir, AA, Hoy, DG, Alam, NKM, Abate, KH, Ghiwot, TT, Gebremedhin, AT, Abbas, KM, Abd El Razek, MM, Abd-Allah, F, Abdulle, AM, Abera, SF, Melaku, YA, Tesfay, Fisaha, Abyu, GY, Bayou, TA, Betsu, BD, Gebru, AA, Hailu, GB, Tekle, T, Yalew, AZ, Yebyo, HG, Abubakar, I, Aldridge, RW, Abu-Raddad, LJ, Abu-Rmeileh, NME, Adebiyi, AO, Adedeji, IA, Adelekan, AL, Ojelabi, FA, Adofo, K, Adou, AK, Akinyemiju, TF, Schwebel, DC, Singh, JA, Akseer, N, Al Lami, FH, Al-Aly, Z, Alam, K, Weintraub, RG, Chiang, PP, Meretoja, A, Lopez, AD, Wijeratne, T, Driscoll, TR, Kemp, AH, Leigh, J, Mekonnen, Alemayehu, Karema, CK, Alasfoor, D, Aldhahri, SFS, Terkawi, AS, Alegretti, MA, Aleman, AV, Alemu, ZA, Cooper, C, Deribew, A, Wang, H, Wolock, TM, Carter, A, Nguyen, G, Kyu, HH, Gakidou, E, Hay, SI, Msemburi, W, Coates, MM, Mooney, MD, Fraser, MS, Sligar, A, Larson, HJ, Friedman, J, Brown, A, Dandona, L, Fullman, N, Haagsma, J, Khalil, I, Lim, SS, Mikesell, J, Mokdad, AH, Moradi-Lakeh, M, Pearson, K, Silpakit, B, Sorensen, MJD, Temesgen, AM, Vollset, SE, Zoeckler, L, Murray, CJL, Alfonso-Cristancho, R, Harun, KM, Prokop, DM, Mills, EJ, Trickey, A, Ajala, ON, Bärnighausen, T, Ding, EL, Farvid, MS, Thorne-Lyman, AL, Won, S, Fitchett, JRA, Salomon, J, Abajobir, AA, Hoy, DG, Alam, NKM, Abate, KH, Ghiwot, TT, Gebremedhin, AT, Abbas, KM, Abd El Razek, MM, Abd-Allah, F, Abdulle, AM, Abera, SF, Melaku, YA, Tesfay, Fisaha, Abyu, GY, Bayou, TA, Betsu, BD, Gebru, AA, Hailu, GB, Tekle, T, Yalew, AZ, Yebyo, HG, Abubakar, I, Aldridge, RW, Abu-Raddad, LJ, Abu-Rmeileh, NME, Adebiyi, AO, Adedeji, IA, Adelekan, AL, Ojelabi, FA, Adofo, K, Adou, AK, Akinyemiju, TF, Schwebel, DC, Singh, JA, Akseer, N, Al Lami, FH, Al-Aly, Z, Alam, K, Weintraub, RG, Chiang, PP, Meretoja, A, Lopez, AD, Wijeratne, T, Driscoll, TR, Kemp, AH, Leigh, J, Mekonnen, Alemayehu, Karema, CK, Alasfoor, D, Aldhahri, SFS, Terkawi, AS, Alegretti, MA, Aleman, AV, Alemu, ZA, Cooper, C, and Deribew, A

Abstract

Background Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015. Methods For countries without high-quality vital registration data, we estimated prevalence and incidence with data from antenatal care clinics and population-based seroprevalence surveys, and with assumptions by age and sex on initial CD4 distribution at infection, CD4 progression rates (probability of progression from higher to lower CD4 cell-count category), on and off antiretroviral therapy (ART) mortality, and mortality from all other causes. Our estimation strategy links the GBD 2015 assessment of all-cause mortality and estimation of incidence and prevalence so that for each draw from the uncertainty distribution all assumptions used in each step are internally consistent. We estimated incidence, prevalence, and death with GBD versions of the Estimation and Projection Package (EPP) and Spectrum software originally developed by the Joint United Nations Programme on HIV/AIDS (UNAIDS). We used an open-source version of EPP and recoded Spectrum for speed, and used updated assumptions from systematic reviews of the literature and GBD demographic data. For countries with high-quality vital registration data, we developed the cohort incidence bias adjustment model to estimate HIV incidence and prevalence largely from the number of deaths caused by HIV recorded in cause-of-death statistics. We corrected these statistics for garbage coding and HIV misclassification. Findings Global HIV incidence reached its peak in 1997, at 3·3 million new infections (95% uncertainty interval [UI] 3·1–3·4 million). Annual incidence has stayed relatively constant at about 2·6 mil

Published
2016

235. Masses of the components of SB2s observed with Gaia - II. Masses derived from PIONIER interferometric observations for Gaia validation

Author

Halbwachs, J. -L., Boffin, H. M. J., Le Bouquin, J. -B., Kiefer, F., Famaey, B., Salomon, J. -B., Arenou, F., Pourbaix, D., Anthonioz, F., Grellmann, R., Guieu, S., Sana, H., Guillout, P., Jorissen, A., Lebreton, Y., Mazeh, T., Tal-Or, L., Gomez-Moran, A. Nebot, Halbwachs, J. -L., Boffin, H. M. J., Le Bouquin, J. -B., Kiefer, F., Famaey, B., Salomon, J. -B., Arenou, F., Pourbaix, D., Anthonioz, F., Grellmann, R., Guieu, S., Sana, H., Guillout, P., Jorissen, A., Lebreton, Y., Mazeh, T., Tal-Or, L., and Gomez-Moran, A. Nebot

Abstract

In anticipation of the Gaia astrometric mission, a sample of spectroscopic binaries is being observed since 2010 with the Spectrograph pour l'Observation des PHenomenes des Interieurs stellaires et des Exoplanetes (SOPHIE) spectrograph at the Haute-Provence Observatory. Our aim is to derive the orbital elements of double-lined spectroscopic binaries (SB2s) with an accuracy sufficient to finally obtain the masses of the components with relative errors as small as 1 per cent when combined with Gaia astrometric measurements. In order to validate the masses derived from Gaia, interferometric observations are obtained for three SB2s in our sample with F-K components: HIP 14157, HIP 20601 and HIP 117186. The masses of the six stellar components are derived. Due to its edge-on orientation, HIP 14157 is probably an eclipsing binary. We note that almost all the derived masses are a few per cent larger than the expectations from the standard spectral type-mass calibration and mass-luminosity relation. Our calculation also leads to accurate parallaxes for the three binaries, and the Hipparcos parallaxes are confirmed.

Published
2016

236. Masses of the components of SB2 binaries observed with Gaia - III. Accurate SB2 orbits for 10 binaries and masses of HIP 87895

Author

Kiefer, F., Halbwachs, Jean-Louis, Arenou, Frédéric, Pourbaix, Dimitri, Famaey, Benoît, Guillout, Patrick, Lebreton, Yveline, Nebot Gómez-Morán, A., Mazeh, Tsevi, Salomon, J.-B., Soubiran, Caroline, Tal-Or, Lev, Kiefer, F., Halbwachs, Jean-Louis, Arenou, Frédéric, Pourbaix, Dimitri, Famaey, Benoît, Guillout, Patrick, Lebreton, Yveline, Nebot Gómez-Morán, A., Mazeh, Tsevi, Salomon, J.-B., Soubiran, Caroline, and Tal-Or, Lev

Abstract

In anticipation of the Gaia astrometric mission, a large sample of spectroscopic binaries has been observed since 2010 with the Spectrographe pour l'Observation des PHénomènes des Intérieurs Stellaires et des Exoplanètes spectrograph at the Haute-Provence Observatory. Our aim is to derive the orbital elements of double-lined spectroscopic binaries (SB2s) with an accuracy sufficient to finally obtain the masses of the components with relative errors as small as 1 per cent when the astrometric measurements of Gaia are taken into account. In this paper, we present the results from five years of observations of 10 SB2 systems with periods ranging from 37 to 881 d. Using the todmor algorithm, we computed radial velocities from the spectra, and then derived the orbital elements of these binary systems. The minimum masses of the components are then obtained with an accuracy better than 1.2 per cent for the 10 binaries. Combining the radial velocities with existing interferometric measurements, we derived the masses of the primary and secondary components of HIP 87895 with an accuracy of 0.98 and 1.2 per cent, respectively., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2016

237. Global, regional, and national levels of maternal mortality, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

Author

Kassebaum, N., Barber, R., Bhutta, Z., Dandona, L., Gething, P., Hay, S., Kinfu, Y., Larson, H., Liang, X., Lim, S., Lopez, A., Lozano, R., Mensah, G., Mokdad, A., Naghavi, M., Pinho, C., Salomon, J., Steiner, C., Vos, T., Wang, H., Abajobir, A., Abate, K., Abbas, K., Abd-Allah, F., Abdallat, M., Abdulle, A., Abera, S., Aboyans, V., Abubakar, I., Abu-Rmeileh, N., Achoki, T., Adebiyi, A., Adedeji, I., Adelekan, A., Adou, A., Afanvi, K., Agarwal, A., Kiadaliri, A., Ajala, O., Akinyemiju, T., Akseer, N., Al-Aly, Z., Alam, K., Alam, N., Alasfoor, D., Aldhahri, S., Aldridge, R., Alhabib, S., Ali, R., Alkerwi, A., Alla, F., Al-Raddadi, R., Alsharif, U., Martin, E., Alvis-Guzman, N., Amare, A., Amberbir, A., Amegah, A., Ammar, W., Amrock, S., Andersen, H., Anderson, G., Antoine, R., Antonio, C., Aregay, A., Arnlov, J., Arora, M., Arsenijevic, V., Al, A., Asayesh, H., Atique, S., Avokpaho, E., Awasthi, A., Quintanilla, B., Azzopardi, P., Bacha, U., Badawi, A., Bahit, M., Balakrishnan, K., Banerjee, A., Barac, A., Barker-Collo, S., Barnighausen, T., Basu, S., Bayou, T., Bayou, Y., Bazargan-Hejazi, S., Beardsley, J., Bedi, N., Bekele, T., Bell, M., Bennett, D., Bensenor, I., Berhane, A., Bernabe, E., Betsu, B., Beyene, A., Biadgilign, S., Bikbov, B., Bin Abdulhak, A., Biroscak, B., Biryukov, S., Bisanzio, D., Bjertness, E., Blore, J., Brainin, M., Brazinova, A., Breitborde, N., Brugha, T., Butt, Z., Campos-Nonato, I., Campuzano, J., Cardenas, R., Carrero, J., Carter, A., Casey, D., Castaneda-Oquela, C., Castro, R., Catala-Lopez, F., Cavalleri, F., Chang, H., Chang, J., Chavan, L., Chibueze, C., Chisumpa, V., Choi, J., Chowdhury, R., Christopher, D., Ciobanu, L., Cirillo, M., Coates, M., Coggeshall, M., Colistro, V., Colquhoun, S., Cooper, C., Cooper, L., Cortinovis, M., Dahiru, T., Damasceno, A., Danawi, H., Dandona, R., Das Neves, J., De Leo, D., Dellavalle, R., Deribe, K., Deribew, A., Jarlais, D., Dharmaratne, S., Dicker, D., Ding, E., Dossou, E., Dubey, M., Ebel, B., Ellingsen, C., Elyazar, I., Endries, A., Ermakov, S., Eshrati, B., Esteghamati, A., Faraon, E., Farid, T., Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Fereshtehnejad, S., Fernandes, J., Fischer, F., Fitchett, J., Fleming, T., Gt, N., Franca, E., Franklin, R., Fraser, M., Friedman, J., Pullman, N., Furst, T., Futran, N., Gambashidze, K., Gamkrelidze, A., Gebre, T., Gebrehiwot, T., Gebremedhin, A., Gebremedhin, M., Gebru, A., Geleijnse, J., Gibney, K., Giref, A., Giroud, M., Gishu, M., Glaser, E., Goenka, S., Gomez-Dantes, H., Gona, P., Goodridge, A., Gopalani, S., Goto, A., Graetz, N., Gugnani, H., Guo, Y., Gupta, R., Gupta, V., Hafezi-Nejad, N., Hailu, A., Hailu, G., Hamadeh, R., Hamidi, S., Hancock, J., Handal, A., Hankey, G., Harb, H., Harikrishnan, S., Harun, K., Havmoeller, R., Hoek, H., Horino, M., Horita, N., Hosgood, H., Hoy, D., Htet, A., Hu, G., Huang, H., Huang, J., Huybrechts, I., Huynh, C., Iannarone, M., Iburg, K., Idrisov, B., Iyer, V., Jacobsen, K., Jahanmehr, N., Jakovljevic, M., Javanbakht, M., Jayatilleke, A., Jee, S., Jeemon, P., Jha, V., Jiang, G., Jiang, Y., Jibat, T., Jonas, J., Kabir, Z., Kamal, R., Kan, H., Karch, A., Karletsos, D., Kasaeian, A., Kaul, A., Kawakami, N., Kayibanda, J., Kazanjan, K., Kazi, D., Keiyoro, P., Kemmer, L., Kemp, A., Kengne, A., Keren, A., Kereselidze, M., Kesavachandran, C., Khader, Y., Khan, A., Khan, E., Khang, Y., Khonelidze, I., Khosravi, A., Khubchandani, J., Kim, Y., Kivipelto, M., Knibbs, L., Kokubo, Y., Kosen, S., Koul, P., Koyanagi, A., Krishnaswami, S., Defo, B., Bicer, B., Kudom, A., Kulikoff, X., Kulkarni, C., Kumar, G., Kutz, M., Lal, D., Lalloo, R., Lam, H., Lamadrid-Figueroa, H., Lan, Q., Larsson, A., Laryea, D., Leigh, J., Leung, R., Li, Y., Lipshultz, S., Liu, P., Liu, S., Liu, Y., Lloyd, B., Lotufo, P., Lunevicius, R., Ma, S., El Razek, H., El Razek, M., Majdan, M., Majeed, A., Malekzadeh, R., Mapoma, C., Marcenes, W., Margolis, D., Marquez, N., Masiye, F., Marzan, M., Mason-Jones, A., Mazorodze, T., Meaney, P., Mehari, A., Mehndiratta, M., Mena-Rodriguez, F., Mekonnen, A., Melaku, Y., Memish, Z., Mendoza, W., Meretoja, A., Meretoja, T., Mhimbira, F., Miller, Ted, Mills, E., Mirarefin, M., Misganaw, A., Ibrahim, N., Mohammad, K., Mohammadi, A., Mohammed, S., Mola, G., Monasta, L., Monis, J., Hernandez, J., Montero, P., Montico, M., Mooney, M., Moore, A., Moradi-Lakeh, M., Morawska, L., Mori, R., Mueller, U., Murthy, G., Murthy, S., Nachega, J., Naheed, A., Naldi, L., Nand, D., Nangia, V., Nash, D., Neupane, S., Newton, J., Ng, M., Ngalesoni, F., Nguhiu, P., Nguyen, G., Le Nguyen, Q., Nisar, M., Nomura, M., Norheim, O., Norman, R., Nyakarahuka, L., Obermeyer, C., Ogbo, F., Oh, I., Ojelabi, F., Olivares, P., Olusanya, B., Olusanya, J., Opio, J., Oren, E., Ota, E., Oyekale, A., Pa, M., Pain, A., Papantoniou, N., Park, E., Park, H., Caicedo, A., Patten, S., Paul, V., Pereira, D., Perico, N., Pesudovs, K., Petzold, M., Phillips, M., Pillay, J., Pishgar, F., Polinder, S., Pope, D., Pourmalek, F., Qorbani, M., Rafay, A., Rahimi, K., Rahimi-Movaghar, V., Rahman, M., Rahman, S., Rai, R., Ram, U., Ranabhat, C., Rangaswamy, T., Rao, P., Refaat, A., Remuzzi, G., Kassebaum, N., Barber, R., Bhutta, Z., Dandona, L., Gething, P., Hay, S., Kinfu, Y., Larson, H., Liang, X., Lim, S., Lopez, A., Lozano, R., Mensah, G., Mokdad, A., Naghavi, M., Pinho, C., Salomon, J., Steiner, C., Vos, T., Wang, H., Abajobir, A., Abate, K., Abbas, K., Abd-Allah, F., Abdallat, M., Abdulle, A., Abera, S., Aboyans, V., Abubakar, I., Abu-Rmeileh, N., Achoki, T., Adebiyi, A., Adedeji, I., Adelekan, A., Adou, A., Afanvi, K., Agarwal, A., Kiadaliri, A., Ajala, O., Akinyemiju, T., Akseer, N., Al-Aly, Z., Alam, K., Alam, N., Alasfoor, D., Aldhahri, S., Aldridge, R., Alhabib, S., Ali, R., Alkerwi, A., Alla, F., Al-Raddadi, R., Alsharif, U., Martin, E., Alvis-Guzman, N., Amare, A., Amberbir, A., Amegah, A., Ammar, W., Amrock, S., Andersen, H., Anderson, G., Antoine, R., Antonio, C., Aregay, A., Arnlov, J., Arora, M., Arsenijevic, V., Al, A., Asayesh, H., Atique, S., Avokpaho, E., Awasthi, A., Quintanilla, B., Azzopardi, P., Bacha, U., Badawi, A., Bahit, M., Balakrishnan, K., Banerjee, A., Barac, A., Barker-Collo, S., Barnighausen, T., Basu, S., Bayou, T., Bayou, Y., Bazargan-Hejazi, S., Beardsley, J., Bedi, N., Bekele, T., Bell, M., Bennett, D., Bensenor, I., Berhane, A., Bernabe, E., Betsu, B., Beyene, A., Biadgilign, S., Bikbov, B., Bin Abdulhak, A., Biroscak, B., Biryukov, S., Bisanzio, D., Bjertness, E., Blore, J., Brainin, M., Brazinova, A., Breitborde, N., Brugha, T., Butt, Z., Campos-Nonato, I., Campuzano, J., Cardenas, R., Carrero, J., Carter, A., Casey, D., Castaneda-Oquela, C., Castro, R., Catala-Lopez, F., Cavalleri, F., Chang, H., Chang, J., Chavan, L., Chibueze, C., Chisumpa, V., Choi, J., Chowdhury, R., Christopher, D., Ciobanu, L., Cirillo, M., Coates, M., Coggeshall, M., Colistro, V., Colquhoun, S., Cooper, C., Cooper, L., Cortinovis, M., Dahiru, T., Damasceno, A., Danawi, H., Dandona, R., Das Neves, J., De Leo, D., Dellavalle, R., Deribe, K., Deribew, A., Jarlais, D., Dharmaratne, S., Dicker, D., Ding, E., Dossou, E., Dubey, M., Ebel, B., Ellingsen, C., Elyazar, I., Endries, A., Ermakov, S., Eshrati, B., Esteghamati, A., Faraon, E., Farid, T., Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Fereshtehnejad, S., Fernandes, J., Fischer, F., Fitchett, J., Fleming, T., Gt, N., Franca, E., Franklin, R., Fraser, M., Friedman, J., Pullman, N., Furst, T., Futran, N., Gambashidze, K., Gamkrelidze, A., Gebre, T., Gebrehiwot, T., Gebremedhin, A., Gebremedhin, M., Gebru, A., Geleijnse, J., Gibney, K., Giref, A., Giroud, M., Gishu, M., Glaser, E., Goenka, S., Gomez-Dantes, H., Gona, P., Goodridge, A., Gopalani, S., Goto, A., Graetz, N., Gugnani, H., Guo, Y., Gupta, R., Gupta, V., Hafezi-Nejad, N., Hailu, A., Hailu, G., Hamadeh, R., Hamidi, S., Hancock, J., Handal, A., Hankey, G., Harb, H., Harikrishnan, S., Harun, K., Havmoeller, R., Hoek, H., Horino, M., Horita, N., Hosgood, H., Hoy, D., Htet, A., Hu, G., Huang, H., Huang, J., Huybrechts, I., Huynh, C., Iannarone, M., Iburg, K., Idrisov, B., Iyer, V., Jacobsen, K., Jahanmehr, N., Jakovljevic, M., Javanbakht, M., Jayatilleke, A., Jee, S., Jeemon, P., Jha, V., Jiang, G., Jiang, Y., Jibat, T., Jonas, J., Kabir, Z., Kamal, R., Kan, H., Karch, A., Karletsos, D., Kasaeian, A., Kaul, A., Kawakami, N., Kayibanda, J., Kazanjan, K., Kazi, D., Keiyoro, P., Kemmer, L., Kemp, A., Kengne, A., Keren, A., Kereselidze, M., Kesavachandran, C., Khader, Y., Khan, A., Khan, E., Khang, Y., Khonelidze, I., Khosravi, A., Khubchandani, J., Kim, Y., Kivipelto, M., Knibbs, L., Kokubo, Y., Kosen, S., Koul, P., Koyanagi, A., Krishnaswami, S., Defo, B., Bicer, B., Kudom, A., Kulikoff, X., Kulkarni, C., Kumar, G., Kutz, M., Lal, D., Lalloo, R., Lam, H., Lamadrid-Figueroa, H., Lan, Q., Larsson, A., Laryea, D., Leigh, J., Leung, R., Li, Y., Lipshultz, S., Liu, P., Liu, S., Liu, Y., Lloyd, B., Lotufo, P., Lunevicius, R., Ma, S., El Razek, H., El Razek, M., Majdan, M., Majeed, A., Malekzadeh, R., Mapoma, C., Marcenes, W., Margolis, D., Marquez, N., Masiye, F., Marzan, M., Mason-Jones, A., Mazorodze, T., Meaney, P., Mehari, A., Mehndiratta, M., Mena-Rodriguez, F., Mekonnen, A., Melaku, Y., Memish, Z., Mendoza, W., Meretoja, A., Meretoja, T., Mhimbira, F., Miller, Ted, Mills, E., Mirarefin, M., Misganaw, A., Ibrahim, N., Mohammad, K., Mohammadi, A., Mohammed, S., Mola, G., Monasta, L., Monis, J., Hernandez, J., Montero, P., Montico, M., Mooney, M., Moore, A., Moradi-Lakeh, M., Morawska, L., Mori, R., Mueller, U., Murthy, G., Murthy, S., Nachega, J., Naheed, A., Naldi, L., Nand, D., Nangia, V., Nash, D., Neupane, S., Newton, J., Ng, M., Ngalesoni, F., Nguhiu, P., Nguyen, G., Le Nguyen, Q., Nisar, M., Nomura, M., Norheim, O., Norman, R., Nyakarahuka, L., Obermeyer, C., Ogbo, F., Oh, I., Ojelabi, F., Olivares, P., Olusanya, B., Olusanya, J., Opio, J., Oren, E., Ota, E., Oyekale, A., Pa, M., Pain, A., Papantoniou, N., Park, E., Park, H., Caicedo, A., Patten, S., Paul, V., Pereira, D., Perico, N., Pesudovs, K., Petzold, M., Phillips, M., Pillay, J., Pishgar, F., Polinder, S., Pope, D., Pourmalek, F., Qorbani, M., Rafay, A., Rahimi, K., Rahimi-Movaghar, V., Rahman, M., Rahman, S., Rai, R., Ram, U., Ranabhat, C., Rangaswamy, T., Rao, P., Refaat, A., and Remuzzi, G.

Published
2016

238. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

Author

Vos, T., Allen, C., Arora, M., Barber, R., Bhutta, Z., Brown, A., Carter, A., Casey, D., Charlson, F., Chen, A., Coggeshall, M., Cornaby, L., Dandona, L., Dicker, D., Dilegge, T., Erskine, H., Ferrari, A., Fitzmaurice, C., Fleming, T., Forouzanfar, M., Fullman, N., Gething, P., Goldberg, E., Graetz, N., Haagsma, J., Johnson, C., Kassebaum, N., Kawashima, T., Kemmer, L., Khalil, I., Kinfu, Y., Kyu, H., Leung, J., Liang, X., Lim, S., Lopez, A., Lozano, R., Marczak, L., Mensah, G., Mokdad, A., Naghavi, M., Nguyen, G., Nsoesie, E., Olsen, H., Pigott, D., Pinho, C., Rankin, Z., Reinig, N., Salomon, J., Sandar, L., Smith, A., Stanaway, J., Steiner, C., Teeple, S., Thomas, B., Troeger, C., Wagner, J., Wang, H., Wanga, V., Whiteford, H., Zoeckler, L., Abajobir, A., Abate, K., Abbafati, C., Abbas, K., Abd-Allah, F., Abraham, B., Abubakar, I., Abu-Raddad, L., Abu-Rmeileh, N., Ackerman, I., Adebiyi, A., Ademi, Z., Adou, A., Afanvi, K., Agardh, E., Agarwal, A., Kiadaliri, A., Ahmadieh, H., Ajala, O., Akinyemi, R., Akseer, N., Al-Aly, Z., Alam, K., Alam, N., Aldhahri, S., Alegretti, M., Alemu, Z., Alexander, L., Alhabib, S., Ali, R., Alkerwi, A., Alla, F., Allebeck, P., Al-Raddadi, R., Alsharif, U., Altirkawi, K., Alvis-Guzman, N., Amare, A., Amberbir, A., Amini, H., Ammar, W., Amrock, S., Andersen, H., Anderson, G., Anderson, B., Antonio, C., Aregay, A., Arnlov, J., Al, A., Asayesh, H., Assadi, R., Atique, S., Avokpaho, E., Awasthi, A., Quintanilla, B., Azzopardi, P., Bacha, U., Badawi, A., Balakrishnan, K., Banerjee, A., Barac, A., Barker-Collo, S., Barnighausen, T., Barregard, L., Barrero, L., Basu, A., Bazargan-Hejazi, S., Bell, B., Bell, M., Bennett, D., Bensenor, I., Benzian, H., Berhane, A., Bernabe, E., Betsu, B., Beyene, A., Bhala, N., Bhatt, S., Biadgilign, S., Bienhofff, K., Bikbov, B., Biryukov, S., Bisanzio, D., Bjertness, E., Blore, J., Borschmann, R., Boufous, S., Brainin, M., Brazinova, A., Breitborde, N., Brown, J., Buchbinder, R., Buckle, G., Butt, Z., Calabria, B., Ricardo Campos-Nonato, I., Cesar Campuzano, J., Carabin, H., Cardenas, R., Carpenter, D., Carrero, J., Castaneda-Orjuela, C., Castillo Rivas, J., Catala-Lopez, F., Chang, J., Chiang, P., Chibueze, C., Chisumpa, V., Choi, J., Chowdhury, R., Christensen, H., Christopher, D., Ciobanu, L., Cirillo, M., Coates, M., Colquhoun, S., Cooper, C., Cortinovis, M., Crump, J., Damtew, S., Dandona, R., Daoud, F., Dargan, P., das Neves, J., Davey, G., Davis, A., De Leo, D., Degenhardt, L., Del Gobbo, L., Dellavalle, R., Deribe, K., Deribew, A., Derrett, S., Des Jarlais, D., Dharmaratne, S., Dhillon, P., Diaz-Torne, C., Ding, E., Driscoll, T., Duan, L., Dubey, M., Duncan, B., Ebrahimi, H., Ellenbogen, R., Elyazar, I., Endres, M., Endries, A., Ermakov, S., Eshrati, B., Estep, K., Farid, T., Sofia e Sa Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Feigin, V., Felson, D., Fereshtehnejad, S., Fernandes, J., Fischer, F., Fitchett, J., Foreman, K., Fowkes, G., Fox, J., Franklin, R., Friedman, J., Frostad, J., Furst, T., Futran, N., Gabbe, B., Ganguly, P., Gankpe, F., Gebre, T., Gebrehiwot, T., Gebremedhin, A., Geleijnse, J., Gessner, B., Gibney, K., Ginawi, I., Giref, A., Giroud, M., Gishu, M., Glaser, E., Godwin, W., Gomez-Dantes, H., Gona, P., Goodridge, A., Gopalani, S., Gotay, C., Goto, A., Gouda, H., Grainger, R., Greaves, F., Guillemin, F., Guo, Y., Gupta, R., Gupta, V., Gutierrez, R., Haile, D., Hailu, A., Hailu, G., Halasa, Y., Hamadeh, R., Hamidi, S., Hammami, M., Hancock, J., Handal, A., Hankey, G., Hao, Y., Harb, H., Harikrishnan, S., Maria Haro, J., Havmoeller, R., Hay, R., Beatriz Heredia-Pi, I., Heydarpour, P., Hoek, H., Horino, M., Horita, N., Hosgood, H., Hoy, D., Htet, A., Huang, H., Huang, J., Huynh, C., Iannarone, M., Iburg, K., Innos, K., Inoue, M., Iyer, V., Jacobsen, K., Jahanmehr, N., Jakovljevic, M., Javanbakht, M., Jayatilleke, A., Jee, S., Jeemon, P., Jensen, P., Jiang, Y., Jibat, T., Jimenez-Corona, A., Jin, Y., Jonas, J., Kabir, Z., Kalkonde, Y., Kamal, R., Kan, H., Karch, A., Karema, C., Karimkhani, C., Kasaeian, A., Kaul, A., Kawakami, N., Keiyoro, P., Kemp, A., Keren, A., Kesavachandran, C., Khader, Y., Khaiff, A., Khaiff, E., Khang, Y., Khera, S., Khoja, T., Khubchandani, J., Kieling, C., Kim, P., Kim, C., Kim, D., Kim, Y., Kissoon, N., Knibbs, L., Knudsen, A., Kokubo, Y., Kolte, D., Kopec, J., Kosen, S., Kotsakis, G., Koul, P., Koyanagi, A., Kravchenko, M., Defo, B., Bicer, B., Kudom, A., Kuipers, E., Kumar, G., Kutz, M., Kwan, G., Lal, A., Lalloo, R., Lallukka, T., Lam, H., Lam, J., Langan, S., Larsson, A., Lavados, P., Leasher, J., Leigh, J., Leung, R., Levi, M., Li, Y., Liang, J., Liu, S., Liu, Y., Lloyd, B., Lo, W., Logroscino, G., Looker, K., Lotufo, P., Lunevicius, R., Lyons, R., Mackay, M., Abd El Razek, M., Mahdavi, M., Majdan, M., Majeed, A., Malekzadeh, R., Marcenes, W., Margolis, D., Martinez-Raga, J., Masiye, F., Massano, J., McGarvey, S., McGrath, J., McKee, M., McMahon, B., Meaney, P., Mehari, A., Meija-Rodriguez, F., Mekonnen, A., Melaku, Y., Memiah, P., Memish, Z., Mendoza, W., Meretoja, A., Meretoja, T., Mhimbira, F., Miller, Ted, Mills, E., Mirarefin, M., Mitchell, P., Mock, C., Mohammadi, A., Mohammed, S., Monasta, L., Montanez Hernandez, J., Montico, M., Mooney, M., Moradi-Lakeh, M., Morawska, L., Mueller, U., Mullany, E., Mumford, J., Murdoch, M., Nachega, J., Nagel, G., Naheed, A., Naldi, L., Nangia, V., Newton, J., Ng, M., Ngalesoni, F., Quyen, L., Nisar, M., Nkamedjie Pete, P., Nona, J., Norheim, O., Norman, R., Norrving, B., Nunes, B., Ogbo, F., Oh, I., Ohkubo, T., Olivares, P., Olusanya, B., Olusanya, J., Ortiz, A., Osman, M., Ota, E., Mahesh, P., Park, E., Parsaeian, M., de Azeredo Passos, V., Paternina Caicedo, A., Patten, S., Patton, G., Pereira, D., Perez-Padilla, R., Perico, N., Pesudovs, K., Petzold, M., Phillips, M., Piel, F., Pillay, J., Pishgar, F., Plass, D., Platts-Mills, J., Polinder, S., Pond, C., Popova, S., Poulton, R., Pourmalek, F., Prabhakaran, D., Prasad, N., Qorbani, M., Rabiee, R., Radfar, A., Rafay, A., Rahimi, K., Rahimi-Movaghar, V., Rahman, M., Rahman, S., Rai, R., Rajsic, S., Ram, U., Rao, P., Refaat, A., Reitsma, M., Remuzzi, G., Resnikofff, S., Reynolds, A., Ribeiro, A., Rios Blancas, M., Rolm, H., Rojas-Rueda, D., Ronfani, L., Roshandel, G., Roth, G., Rothenbacher, D., Roy, A., Sagar, R., Sahathevan, R., Sanabria, J., Dolores Sanchez-Nino, M., Santos, I., Santos, J., Sarmiento-Suarez, R., Sartorius, B., Satpathy, M., Savic, M., Sawhney, M., Schaub, M., Schmidt, M., Schneider, I., Schottker, B., Schwebel, D., Scott, J., Seedat, S., Sepanlou, S., Servan-Mori, E., Shackelford, K., Shaheen, A., Shaikh, M., Sharma, R., Sharma, U., Shen, J., Shepard, D., Sheth, K., Shibuya, K., Shin, M., Shiri, R., Shiue, I., Shrime, M., Sigfusdottir, I., Silva, D., Alves Silveira, D., Singh, A., Singh, J., Singh, O., Singh, P., Sivonda, A., Skirbekk, V., Skogen, J., Sligar, A., Silwa, K., Soljak, M., Soreide, K., Soriano, J., Sposato, L., Sreeramareddy, C., Stathopoulou, V., Steel, N., Stein, D., Steiner, T., Steinke, S., Stovner, L., Stroumpoulis, K., Sunguya, B., Sur, P., Swaminathan, S., Sykes, B., Szoeke, C., Tabares-Seisdedos, R., Takala, J., Landon, N., Tanne, D., Tavakkoli, M., Taye, B., Taylor, H., Te Ao, B., Tedla, B., Terkawi, A., Thomson, A., Thorne-Lyman, A., Thrift, A., Thurston, G., Tobe-Gai, R., Tonelli, M., Topor-Madry, R., Topouzis, F., Tran, B., Dimbuene, Z., Tsilimbaris, M., Tura, A., Tuzcu, E., Tyrovolas, S., Ukwaja, K., Undurraga, E., Uneke, C., Uthman, O., van Gool, C., Varakin, Y., Vasankari, T., Venketasubramanian, N., Verma, R., Violante, F., Vladimirov, S., Vlassov, V., Vollset, S., Wagner, G., Waller, S., Wang, L., Watkins, D., Weichenthal, S., Weiderpass, E., Weintraub, R., Werdecker, A., Westerman, R., White, R., Williams, H., Wiysonge, C., Wolfe, C., Won, S., Woodbrook, R., Wubshet, M., Xavier, D., Xu, G., Yadav, A., Yan, L., Yano, Y., Yaseri, M., Ye, P., Yebyo, H., Yip, P., Yonemoto, N., Yoon, S., Younis, M., Yu, C., Zaidi, Z., Zaki, M., Zeeb, H., Zhou, M., Zodpey, S., Zuhlke, L., Murray, C., Vos, T., Allen, C., Arora, M., Barber, R., Bhutta, Z., Brown, A., Carter, A., Casey, D., Charlson, F., Chen, A., Coggeshall, M., Cornaby, L., Dandona, L., Dicker, D., Dilegge, T., Erskine, H., Ferrari, A., Fitzmaurice, C., Fleming, T., Forouzanfar, M., Fullman, N., Gething, P., Goldberg, E., Graetz, N., Haagsma, J., Johnson, C., Kassebaum, N., Kawashima, T., Kemmer, L., Khalil, I., Kinfu, Y., Kyu, H., Leung, J., Liang, X., Lim, S., Lopez, A., Lozano, R., Marczak, L., Mensah, G., Mokdad, A., Naghavi, M., Nguyen, G., Nsoesie, E., Olsen, H., Pigott, D., Pinho, C., Rankin, Z., Reinig, N., Salomon, J., Sandar, L., Smith, A., Stanaway, J., Steiner, C., Teeple, S., Thomas, B., Troeger, C., Wagner, J., Wang, H., Wanga, V., Whiteford, H., Zoeckler, L., Abajobir, A., Abate, K., Abbafati, C., Abbas, K., Abd-Allah, F., Abraham, B., Abubakar, I., Abu-Raddad, L., Abu-Rmeileh, N., Ackerman, I., Adebiyi, A., Ademi, Z., Adou, A., Afanvi, K., Agardh, E., Agarwal, A., Kiadaliri, A., Ahmadieh, H., Ajala, O., Akinyemi, R., Akseer, N., Al-Aly, Z., Alam, K., Alam, N., Aldhahri, S., Alegretti, M., Alemu, Z., Alexander, L., Alhabib, S., Ali, R., Alkerwi, A., Alla, F., Allebeck, P., Al-Raddadi, R., Alsharif, U., Altirkawi, K., Alvis-Guzman, N., Amare, A., Amberbir, A., Amini, H., Ammar, W., Amrock, S., Andersen, H., Anderson, G., Anderson, B., Antonio, C., Aregay, A., Arnlov, J., Al, A., Asayesh, H., Assadi, R., Atique, S., Avokpaho, E., Awasthi, A., Quintanilla, B., Azzopardi, P., Bacha, U., Badawi, A., Balakrishnan, K., Banerjee, A., Barac, A., Barker-Collo, S., Barnighausen, T., Barregard, L., Barrero, L., Basu, A., Bazargan-Hejazi, S., Bell, B., Bell, M., Bennett, D., Bensenor, I., Benzian, H., Berhane, A., Bernabe, E., Betsu, B., Beyene, A., Bhala, N., Bhatt, S., Biadgilign, S., Bienhofff, K., Bikbov, B., Biryukov, S., Bisanzio, D., Bjertness, E., Blore, J., Borschmann, R., Boufous, S., Brainin, M., Brazinova, A., Breitborde, N., Brown, J., Buchbinder, R., Buckle, G., Butt, Z., Calabria, B., Ricardo Campos-Nonato, I., Cesar Campuzano, J., Carabin, H., Cardenas, R., Carpenter, D., Carrero, J., Castaneda-Orjuela, C., Castillo Rivas, J., Catala-Lopez, F., Chang, J., Chiang, P., Chibueze, C., Chisumpa, V., Choi, J., Chowdhury, R., Christensen, H., Christopher, D., Ciobanu, L., Cirillo, M., Coates, M., Colquhoun, S., Cooper, C., Cortinovis, M., Crump, J., Damtew, S., Dandona, R., Daoud, F., Dargan, P., das Neves, J., Davey, G., Davis, A., De Leo, D., Degenhardt, L., Del Gobbo, L., Dellavalle, R., Deribe, K., Deribew, A., Derrett, S., Des Jarlais, D., Dharmaratne, S., Dhillon, P., Diaz-Torne, C., Ding, E., Driscoll, T., Duan, L., Dubey, M., Duncan, B., Ebrahimi, H., Ellenbogen, R., Elyazar, I., Endres, M., Endries, A., Ermakov, S., Eshrati, B., Estep, K., Farid, T., Sofia e Sa Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Feigin, V., Felson, D., Fereshtehnejad, S., Fernandes, J., Fischer, F., Fitchett, J., Foreman, K., Fowkes, G., Fox, J., Franklin, R., Friedman, J., Frostad, J., Furst, T., Futran, N., Gabbe, B., Ganguly, P., Gankpe, F., Gebre, T., Gebrehiwot, T., Gebremedhin, A., Geleijnse, J., Gessner, B., Gibney, K., Ginawi, I., Giref, A., Giroud, M., Gishu, M., Glaser, E., Godwin, W., Gomez-Dantes, H., Gona, P., Goodridge, A., Gopalani, S., Gotay, C., Goto, A., Gouda, H., Grainger, R., Greaves, F., Guillemin, F., Guo, Y., Gupta, R., Gupta, V., Gutierrez, R., Haile, D., Hailu, A., Hailu, G., Halasa, Y., Hamadeh, R., Hamidi, S., Hammami, M., Hancock, J., Handal, A., Hankey, G., Hao, Y., Harb, H., Harikrishnan, S., Maria Haro, J., Havmoeller, R., Hay, R., Beatriz Heredia-Pi, I., Heydarpour, P., Hoek, H., Horino, M., Horita, N., Hosgood, H., Hoy, D., Htet, A., Huang, H., Huang, J., Huynh, C., Iannarone, M., Iburg, K., Innos, K., Inoue, M., Iyer, V., Jacobsen, K., Jahanmehr, N., Jakovljevic, M., Javanbakht, M., Jayatilleke, A., Jee, S., Jeemon, P., Jensen, P., Jiang, Y., Jibat, T., Jimenez-Corona, A., Jin, Y., Jonas, J., Kabir, Z., Kalkonde, Y., Kamal, R., Kan, H., Karch, A., Karema, C., Karimkhani, C., Kasaeian, A., Kaul, A., Kawakami, N., Keiyoro, P., Kemp, A., Keren, A., Kesavachandran, C., Khader, Y., Khaiff, A., Khaiff, E., Khang, Y., Khera, S., Khoja, T., Khubchandani, J., Kieling, C., Kim, P., Kim, C., Kim, D., Kim, Y., Kissoon, N., Knibbs, L., Knudsen, A., Kokubo, Y., Kolte, D., Kopec, J., Kosen, S., Kotsakis, G., Koul, P., Koyanagi, A., Kravchenko, M., Defo, B., Bicer, B., Kudom, A., Kuipers, E., Kumar, G., Kutz, M., Kwan, G., Lal, A., Lalloo, R., Lallukka, T., Lam, H., Lam, J., Langan, S., Larsson, A., Lavados, P., Leasher, J., Leigh, J., Leung, R., Levi, M., Li, Y., Liang, J., Liu, S., Liu, Y., Lloyd, B., Lo, W., Logroscino, G., Looker, K., Lotufo, P., Lunevicius, R., Lyons, R., Mackay, M., Abd El Razek, M., Mahdavi, M., Majdan, M., Majeed, A., Malekzadeh, R., Marcenes, W., Margolis, D., Martinez-Raga, J., Masiye, F., Massano, J., McGarvey, S., McGrath, J., McKee, M., McMahon, B., Meaney, P., Mehari, A., Meija-Rodriguez, F., Mekonnen, A., Melaku, Y., Memiah, P., Memish, Z., Mendoza, W., Meretoja, A., Meretoja, T., Mhimbira, F., Miller, Ted, Mills, E., Mirarefin, M., Mitchell, P., Mock, C., Mohammadi, A., Mohammed, S., Monasta, L., Montanez Hernandez, J., Montico, M., Mooney, M., Moradi-Lakeh, M., Morawska, L., Mueller, U., Mullany, E., Mumford, J., Murdoch, M., Nachega, J., Nagel, G., Naheed, A., Naldi, L., Nangia, V., Newton, J., Ng, M., Ngalesoni, F., Quyen, L., Nisar, M., Nkamedjie Pete, P., Nona, J., Norheim, O., Norman, R., Norrving, B., Nunes, B., Ogbo, F., Oh, I., Ohkubo, T., Olivares, P., Olusanya, B., Olusanya, J., Ortiz, A., Osman, M., Ota, E., Mahesh, P., Park, E., Parsaeian, M., de Azeredo Passos, V., Paternina Caicedo, A., Patten, S., Patton, G., Pereira, D., Perez-Padilla, R., Perico, N., Pesudovs, K., Petzold, M., Phillips, M., Piel, F., Pillay, J., Pishgar, F., Plass, D., Platts-Mills, J., Polinder, S., Pond, C., Popova, S., Poulton, R., Pourmalek, F., Prabhakaran, D., Prasad, N., Qorbani, M., Rabiee, R., Radfar, A., Rafay, A., Rahimi, K., Rahimi-Movaghar, V., Rahman, M., Rahman, S., Rai, R., Rajsic, S., Ram, U., Rao, P., Refaat, A., Reitsma, M., Remuzzi, G., Resnikofff, S., Reynolds, A., Ribeiro, A., Rios Blancas, M., Rolm, H., Rojas-Rueda, D., Ronfani, L., Roshandel, G., Roth, G., Rothenbacher, D., Roy, A., Sagar, R., Sahathevan, R., Sanabria, J., Dolores Sanchez-Nino, M., Santos, I., Santos, J., Sarmiento-Suarez, R., Sartorius, B., Satpathy, M., Savic, M., Sawhney, M., Schaub, M., Schmidt, M., Schneider, I., Schottker, B., Schwebel, D., Scott, J., Seedat, S., Sepanlou, S., Servan-Mori, E., Shackelford, K., Shaheen, A., Shaikh, M., Sharma, R., Sharma, U., Shen, J., Shepard, D., Sheth, K., Shibuya, K., Shin, M., Shiri, R., Shiue, I., Shrime, M., Sigfusdottir, I., Silva, D., Alves Silveira, D., Singh, A., Singh, J., Singh, O., Singh, P., Sivonda, A., Skirbekk, V., Skogen, J., Sligar, A., Silwa, K., Soljak, M., Soreide, K., Soriano, J., Sposato, L., Sreeramareddy, C., Stathopoulou, V., Steel, N., Stein, D., Steiner, T., Steinke, S., Stovner, L., Stroumpoulis, K., Sunguya, B., Sur, P., Swaminathan, S., Sykes, B., Szoeke, C., Tabares-Seisdedos, R., Takala, J., Landon, N., Tanne, D., Tavakkoli, M., Taye, B., Taylor, H., Te Ao, B., Tedla, B., Terkawi, A., Thomson, A., Thorne-Lyman, A., Thrift, A., Thurston, G., Tobe-Gai, R., Tonelli, M., Topor-Madry, R., Topouzis, F., Tran, B., Dimbuene, Z., Tsilimbaris, M., Tura, A., Tuzcu, E., Tyrovolas, S., Ukwaja, K., Undurraga, E., Uneke, C., Uthman, O., van Gool, C., Varakin, Y., Vasankari, T., Venketasubramanian, N., Verma, R., Violante, F., Vladimirov, S., Vlassov, V., Vollset, S., Wagner, G., Waller, S., Wang, L., Watkins, D., Weichenthal, S., Weiderpass, E., Weintraub, R., Werdecker, A., Westerman, R., White, R., Williams, H., Wiysonge, C., Wolfe, C., Won, S., Woodbrook, R., Wubshet, M., Xavier, D., Xu, G., Yadav, A., Yan, L., Yano, Y., Yaseri, M., Ye, P., Yebyo, H., Yip, P., Yonemoto, N., Yoon, S., Younis, M., Yu, C., Zaidi, Z., Zaki, M., Zeeb, H., Zhou, M., Zodpey, S., Zuhlke, L., and Murray, C.

Abstract

© 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY licenseBackground Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015. Methods We estimated incidence and prevalence by age, sex, cause, year, and geography with a wide range of updated and standardised analytical procedures. Improvements from GBD 2013 included the addition of new data sources, updates to literature reviews for 85 causes, and the identification and inclusion of additional studies published up to November, 2015, to expand the database used for estimation of non-fatal outcomes to 60?900 unique data sources. Prevalence and incidence by cause and sequelae were determined with DisMod-MR 2.1, an improved version of the DisMod-MR Bayesian meta-regression tool first developed for GBD 2010 and GBD 2013. For some causes, we used alternative modelling strategies where the complexity of the disease was not suited to DisMod-MR 2.1 or where incidence and prevalence needed to be determined from other data. For GBD 2015 we created a summary indicator that combines measures of income per capita, educational attainment, and fertility (the Socio-demographic Index [SDI]) and used it to compare observed patterns of health loss to the expected pattern for countries or locations with similar SDI scores. Findings We generated 9·3 billion estimates from the various combinations of prevalence, incidence, and YLDs for causes, sequelae, and impairments by age, sex, geography, and year.

Published
2016

239. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015

Author

Wang, H., Naghavi, M., Allen, C., Barber, R., Bhutta, Z., Carter, A., Casey, D., Charlson, F., Chen, A., Coates, M., Coggeshall, M., Dandona, L., Dicker, D., Erskine, H., Ferrari, A., Fitzmaurice, C., Foreman, K., Forouzanfar, M., Fraser, M., Pullman, N., Gething, P., Goldberg, E., Graetz, N., Haagsma, J., Hay, S., Huynh, C., Johnson, C., Kassebaum, N., Kinfu, Y., Kulikoff, X., Kutz, M., Kyu, H., Larson, H., Leung, J., Liang, X., Lim, S., Lind, M., Lozano, R., Marquez, N., Mensah, G., Mikesell, J., Mokdad, A., Mooney, M., Nguyen, G., Nsoesie, E., Pigott, D., Pinho, C., Roth, G., Salomon, J., Sandar, L., Silpakit, N., Sligar, A., Sorensen, R., Stanaway, J., Steiner, C., Teeple, S., Thomas, B., Troeger, C., VanderZanden, A., Vollset, S., Wanga, V., Whiteford, H., Wolock, T., Zoeckler, L., Abate, K., Abbafati, C., Abbas, K., Abd-Allah, F., Abera, S., Abreu, D., Abu-Raddad, L., Abyu, G., Achoki, T., Adelekan, A., Ademi, Z., Adou, A., Adsuar, J., Afanvi, K., Afshin, A., Agardh, E., Agarwal, A., Agrawal, A., Kiadaliri, A., Ajala, O., Akanda, A., Akinyemi, R., Akinyemiju, T., Akseer, N., Al Lami, F., Alabed, S., Al-Aly, Z., Alam, K., Alam, N., Alasfoor, D., Aldhahri, S., Aldridge, R., Alegretti, M., Aleman, A., Alemu, Z., Alexander, L., Alhabib, S., Ali, R., Alkerwi, A., Alla, F., Allebeck, P., Al-Raddadi, R., Alsharif, U., Altirkawi, K., Martin, E., Alvis-Guzman, N., Amare, A., Amegah, A., Ameh, E., Amini, H., Ammar, W., Amrock, S., Andersen, H., Anderson, B., Anderson, G., Antonio, C., Aregay, A., Arnlov, J., Arsenijevic, V., Al, A., Asayesh, H., Asghar, R., Atique, S., Arthur Avokpaho, E., Awasthi, A., Azzopardi, P., Bacha, U., Badawi, A., Bahit, M., Balakrishnan, K., Banerjee, A., Barac, A., Barker-Collo, S., Barnighausen, T., Barregard, L., Barrero, L., Basu, A., Basu, S., Bayou, Y., Bazargan-Hejazi, S., Beardsley, J., Bedi, N., Beghi, E., Belay, H., Bell, B., Bell, M., Bello, A., Bennett, D., Bensenor, I., Berhane, A., Bernabe, E., Betsu, B., Beyene, A., Bhala, N., Bhalla, A., Biadgilign, S., Bikbov, B., Bin Abdulhak, A., Biroscak, B., Biryukov, S., Bjertness, E., Blore, J., Blosser, C., Bohensky, M., Borschmann, R., Bose, D., Bourne, R., Brainin, M., Brayne, C., Brazinova, A., Breitborde, N., Brenner, H., Brewer, J., Brown, A., Brown, J., Brugha, T., Buckle, G., Butt, Z., Calabria, B., Campos-Novato, I., Campuzano, J., Carapetis, J., Cardenas, R., Carpenter, D., Carrero, J., Castaneda-Oquela, C., Rivas, J., Catala-Lopez, F., Cavalleri, F., Cercy, K., Cerda, J., Chen, W., Chew, A., Chiang, P., Chibalabala, M., Chibueze, C., Chimed-Ochir, O., Chisumpa, V., Choi, J., Chowdhury, R., Christensen, H., Christopher, D., Ciobanu, L., Cirillo, M., Cohen, A., Colistro, V., Colomar, M., Colquhoun, S., Cooper, C., Cooper, L., Cortinovis, M., Cowie, B., Crump, J., Damsere-Derry, J., Danawi, H., Dandona, R., Daoud, F., Darby, S., Dargan, P., das Neves, J., Davey, G., Davis, A., Davitoiu, D., de Castro, E., de Jager, P., De Leo, D., Degenhardt, L., Dellavalle, R., Deribe, K., Deribew, A., Dharmaratne, S., Dhillon, P., Diaz-Torne, C., Ding, E., dos Santos, K., Dossou, E., Driscoll, T., Duan, L., Dubey, M., Bartholow, B., Ellenbogen, R., Lycke, C., Elyazar, I., Endries, A., Ermakov, S., Eshrati, B., Esteghamati, A., Estep, K., Faghmous, I., Fahimi, S., Jose, E., Farid, T., Sa Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Feigin, V., Fereshtehnejad, S., Fernandes, J., Fischer, F., Fitchett, J., Flaxman, A., Foigt, N., Fowkes, F., Franca, E., Franklin, R., Friedman, J., Frostad, J., Hirst, T., Futran, N., Gall, S., Gambashidze, K., Gamkrelidze, A., Ganguly, P., Gankpe, F., Gebre, T., Gebrehiwot, T., Gebremedhin, A., Gebru, A., Geleijnse, J., Gessner, B., Ghoshal, A., Gibney, K., Gillum, R., Gilmour, S., Giref, A., Giroud, M., Gishu, M., Giussani, G., Glaser, E., Godwin, W., Gomez-Dantes, H., Gona, P., Goodridge, A., Gopalani, S., Gosselin, R., Gotay, C., Goto, A., Gouda, H., Greaves, F., Gugnani, H., Gupta, R., Gupta, V., Gutierrez, R., Hafezi-Nejad, N., Haile, D., Hailu, A., Hailu, G., Halasa, Y., Hamadeh, R., Hamidi, S., Hancock, J., Handal, A., Hankey, G., Hao, Y., Harb, H., Harikrishnan, S., Haro, J., Havmoeller, R., Heckbert, S., Heredia-Pi, I., Heydarpour, P., Hilderink, H., Hoek, H., Hogg, R., Horino, M., Horita, N., Hosgood, H., Hotez, P., Hoy, D., Hsairi, M., Htet, A., Than Htike, M., Hu, G., Huang, C., Huang, H., Huiart, L., Husseini, A., Huybrechts, I., Huynh, G., Iburg, K., Innos, K., Inoue, M., Iyer, V., Jacobs, T., Jacobsen, K., Jahanmehr, N., Jakovljevic, M., James, P., Javanbakht, M., Jayaraman, S., Jayatilleke, A., Jeemon, P., Jensen, P., Jha, V., Jiang, G., Jiang, Y., Jibat, T., Jimenez-Corona, A., Jonas, J., Joshi, T., Kabir, Z., Karnak, R., Kan, H., Kant, S., Karch, A., Karema, C., Karimkhani, C., Karletsos, D., Karthikeyan, G., Kasaeian, A., Katibeh, M., Kaul, A., Kawakami, N., Kayibanda, J., Keiyoro, P., Kemmer, L., Kemp, A., Kengne, A., Keren, A., Kereselidze, M., Kesavachandran, C., Khader, Y., Khalil, I., Khan, A., Khan, E., Khang, Y., Khera, S., Muthafer Khoja, T., Kieling, C., Kim, D., Kim, Y., Kissela, B., Kissoon, N., Knibbs, L., Knudsen, A., Kokubo, Y., Kolte, D., Kopec, J., Kosen, S., Koul, P., Koyanagi, A., Krog, N., Defo, B., Bicer, B., Kudom, A., Kuipers, E., Kulkarni, V., Kumar, G., Kwan, G., Lal, A., Lal, D., Lalloo, R., Lam, H., Lam, J., Langan, S., Lansingh, V., Larsson, A., Laryea, D., Latif, A., Lawrynowicz, A., Leigh, J., Levi, M., Li, Y., Lindsay, M., Lipshultz, S., Liu, P., Liu, S., Liu, Y., Lo, L., Logroscino, G., Lotufo, P., Lucas, R., Lunevicius, R., Lyons, R., Ma, S., Pedro Machado, V., Mackay, M., MacLachlan, J., Abd El Razek, H., Abd El Razek, M., Majdan, M., Majeed, A., Malekzadeh, R., Ayele Manamo, W., Mandisarisa, J., Mangalam, S., Mapoma, C., Marcenes, W., Margolis, D., Martin, G., Martinez-Raga, J., Marzan, M., Masiye, F., Mason-Jones, A., Massano, J., Matzopoulos, R., Mayosi, B., McGarvey, S., McGrath, J., Mckee, M., McMahon, B., Meaney, P., Mehari, A., Mehndiratta, M., Mena-Rodriguez, F., Mekonnen, A., Melaku, Y., Memiah, P., Memish, Z., Mendoza, W., Meretoja, A., Meretoja, T., Mhimbira, F., Micha, R., Miller, Ted, Mirarefin, M., Misganaw, A., Mock, C., Abdulmuhsin Mohammad, K., Mohammadi, A., Mohammed, S., Mohan, V., Mola, G., Monasta, L., Montanez Hernandez, J., Montero, P., Montico, M., Montine, T., Moradi-Lakeh, M., Morawska, L., Morgan, K., Mori, R., Mozaffarian, D., Mueller, U., Satyanarayana Murthy, G., Murthy, S., Musa, K., Nachega, J., Nagel, G., Naidoo, K., Naik, N., Naldi, L., Nangia, V., Nash, D., Nejjari, C., Neupane, S., Newton, C., Newton, J., Ng, M., Ngalesoni, F., Ngirabega, J., Quyen, L., Nisar, M., Nkamedjie Pete, P., Nomura, M., Norheim, O., Norman, P., Norrving, B., Nyakarahuka, L., Ogbo, F., Ohkubo, T., Ojelabi, F., Olivares, P., Olusanya, B., Olusanya, J., Opio, J., Oren, E., Ortiz, A., Osman, M., Ota, E., Ozdemir, R., Pa, M., Pandian, J., Pant, P., Papachristou, C., Park, E., Park, J., Parry, C., Parsaeian, M., Caicedo, A., Patten, S., Patton, G., Paul, V., Pearce, N., Pedro, J., Stokic, L., Pereira, D., Perico, N., Pesudovs, K., Petzold, M., Phillips, M., Piel, F., Pillay, J., Plass, D., Platts-Mills, J., Polinder, S., Pope, C., Popova, S., Poulton, R., Pourmalek, F., Prabhakaran, D., Qorbani, M., Quame-Amaglo, J., Quistberg, D., Rafay, A., Rahimi, K., Rahimi-Movaghar, V., Rahman, M., Rahman, S., Rai, R., Rajavi, Z., Rajsic, S., Raju, M., Rakovac, I., Rana, S., Ranabhat, C., Rangaswamy, T., Rao, P., Rao, S., Refaat, A., Rehm, J., Reitsma, M., Remuzzi, G., Resnikofff, S., Ribeiro, A., Ricci, S., Blancas, M., Roberts, B., Roca, A., Rojas-Rueda, D., Ronfani, L., Roshandel, G., Rothenbacher, D., Roy, A., Roy, N., Ruhago, G., Sagar, R., Saha, S., Sahathevan, R., Saleh, M., Sanabria, J., Sanchez-Nino, M., Sanchez-Riera, L., Santos, I., Sarmiento-Suarez, R., Sartorius, B., Satpathy, M., Savic, M., Sawhney, M., Schaub, M., Schmidt, M., Schneider, I., Schottker, B., Schutte, A., Schwebel, D., Seedat, S., Sepanlou, S., Servan-Mori, E., Shackelford, K., Shaddick, G., Shaheen, A., Shahraz, S., Shaikh, M., Shakh-Nazarova, M., Sharma, R., She, J., Sheikhbahaei, S., Shen, J., Shen, Z., Shepard, D., Sheth, K., Shetty, B., Shi, P., Shibuya, K., Shin, M., Shiri, R., Shiue, I., Shrime, M., Sigfusdottir, I., Silberberg, D., Silva, D., Silveira, D., Silverberg, J., Simard, E., Singh, A., Singh, G., Singh, J., Singh, O., Singh, P., Singh, V., Soneji, S., Soreide, K., Soriano, J., Sposato, L., Sreeramareddy, C., Stathopoulou, V., Stein, D., Stein, M., Stranges, S., Stroumpoulis, K., Sunguya, B., Sur, P., Swaminathan, S., Sykes, B., Szoeke, C., Tabares-Seisdedos, R., Tabb, K., Takahashi, K., Takala, J., Talongwa, R., Tandon, N., Tavakkoli, M., Taye, B., Taylor, H., Ao, B., Tedla, B., Tefera, W., Ten Have, M., Terkawi, A., Tesfay, F., Tessema, G., Thomson, A., Thorne-Lyman, A., Thrift, A., Thurston, G., Tillmann, T., Tirschwell, D., Tonelli, M., Topor-Madry, R., Topouzis, F., Nx, J., Traebert, J., Tran, B., Truelsen, T., Trujillo, U., Tura, A., Tuzcu, E., Uchendu, U., Ukwaja, K., Undurraga, E., Uthman, O., Van Dingenen, R., Van Donkelaar, A., Vasankari, T., Vasconcelos, A., Venketasubramanian, N., Vidavalur, R., Vijayakumar, L., Villalpando, S., Violante, F., Vlassov, V., Wagner, J., Wagner, G., Wallin, M., Wang, L., Watkins, D., Weichenthal, S., Weiderpass, E., Weintraub, R., Werdecker, A., Westerman, R., White, R., Wijeratne, T., Wilkinson, J., Williams, H., Wiysonge, C., Woldeyohannes, S., Wolfe, C., Won, S., Wong, J., Woolf, A., Xavier, D., Xiao, Q., Xu, G., Yakob, B., Yalew, A., Yan, L., Yano, Y., Yaseri, M., Ye, P., Yebyo, H., Yip, P., Yirsaw, B., Yonemoto, N., Yonga, G., Younis, M., Yu, S., Zaidi, Z., Zaki, M., Zannad, F., Zavala, D., Zeeb, H., Zeleke, B., Zhang, H., Zodpey, S., Zonies, D., Zuhlke, L., Vos, T., Lopez, A., Murray, C., Wang, H., Naghavi, M., Allen, C., Barber, R., Bhutta, Z., Carter, A., Casey, D., Charlson, F., Chen, A., Coates, M., Coggeshall, M., Dandona, L., Dicker, D., Erskine, H., Ferrari, A., Fitzmaurice, C., Foreman, K., Forouzanfar, M., Fraser, M., Pullman, N., Gething, P., Goldberg, E., Graetz, N., Haagsma, J., Hay, S., Huynh, C., Johnson, C., Kassebaum, N., Kinfu, Y., Kulikoff, X., Kutz, M., Kyu, H., Larson, H., Leung, J., Liang, X., Lim, S., Lind, M., Lozano, R., Marquez, N., Mensah, G., Mikesell, J., Mokdad, A., Mooney, M., Nguyen, G., Nsoesie, E., Pigott, D., Pinho, C., Roth, G., Salomon, J., Sandar, L., Silpakit, N., Sligar, A., Sorensen, R., Stanaway, J., Steiner, C., Teeple, S., Thomas, B., Troeger, C., VanderZanden, A., Vollset, S., Wanga, V., Whiteford, H., Wolock, T., Zoeckler, L., Abate, K., Abbafati, C., Abbas, K., Abd-Allah, F., Abera, S., Abreu, D., Abu-Raddad, L., Abyu, G., Achoki, T., Adelekan, A., Ademi, Z., Adou, A., Adsuar, J., Afanvi, K., Afshin, A., Agardh, E., Agarwal, A., Agrawal, A., Kiadaliri, A., Ajala, O., Akanda, A., Akinyemi, R., Akinyemiju, T., Akseer, N., Al Lami, F., Alabed, S., Al-Aly, Z., Alam, K., Alam, N., Alasfoor, D., Aldhahri, S., Aldridge, R., Alegretti, M., Aleman, A., Alemu, Z., Alexander, L., Alhabib, S., Ali, R., Alkerwi, A., Alla, F., Allebeck, P., Al-Raddadi, R., Alsharif, U., Altirkawi, K., Martin, E., Alvis-Guzman, N., Amare, A., Amegah, A., Ameh, E., Amini, H., Ammar, W., Amrock, S., Andersen, H., Anderson, B., Anderson, G., Antonio, C., Aregay, A., Arnlov, J., Arsenijevic, V., Al, A., Asayesh, H., Asghar, R., Atique, S., Arthur Avokpaho, E., Awasthi, A., Azzopardi, P., Bacha, U., Badawi, A., Bahit, M., Balakrishnan, K., Banerjee, A., Barac, A., Barker-Collo, S., Barnighausen, T., Barregard, L., Barrero, L., Basu, A., Basu, S., Bayou, Y., Bazargan-Hejazi, S., Beardsley, J., Bedi, N., Beghi, E., Belay, H., Bell, B., Bell, M., Bello, A., Bennett, D., Bensenor, I., Berhane, A., Bernabe, E., Betsu, B., Beyene, A., Bhala, N., Bhalla, A., Biadgilign, S., Bikbov, B., Bin Abdulhak, A., Biroscak, B., Biryukov, S., Bjertness, E., Blore, J., Blosser, C., Bohensky, M., Borschmann, R., Bose, D., Bourne, R., Brainin, M., Brayne, C., Brazinova, A., Breitborde, N., Brenner, H., Brewer, J., Brown, A., Brown, J., Brugha, T., Buckle, G., Butt, Z., Calabria, B., Campos-Novato, I., Campuzano, J., Carapetis, J., Cardenas, R., Carpenter, D., Carrero, J., Castaneda-Oquela, C., Rivas, J., Catala-Lopez, F., Cavalleri, F., Cercy, K., Cerda, J., Chen, W., Chew, A., Chiang, P., Chibalabala, M., Chibueze, C., Chimed-Ochir, O., Chisumpa, V., Choi, J., Chowdhury, R., Christensen, H., Christopher, D., Ciobanu, L., Cirillo, M., Cohen, A., Colistro, V., Colomar, M., Colquhoun, S., Cooper, C., Cooper, L., Cortinovis, M., Cowie, B., Crump, J., Damsere-Derry, J., Danawi, H., Dandona, R., Daoud, F., Darby, S., Dargan, P., das Neves, J., Davey, G., Davis, A., Davitoiu, D., de Castro, E., de Jager, P., De Leo, D., Degenhardt, L., Dellavalle, R., Deribe, K., Deribew, A., Dharmaratne, S., Dhillon, P., Diaz-Torne, C., Ding, E., dos Santos, K., Dossou, E., Driscoll, T., Duan, L., Dubey, M., Bartholow, B., Ellenbogen, R., Lycke, C., Elyazar, I., Endries, A., Ermakov, S., Eshrati, B., Esteghamati, A., Estep, K., Faghmous, I., Fahimi, S., Jose, E., Farid, T., Sa Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Feigin, V., Fereshtehnejad, S., Fernandes, J., Fischer, F., Fitchett, J., Flaxman, A., Foigt, N., Fowkes, F., Franca, E., Franklin, R., Friedman, J., Frostad, J., Hirst, T., Futran, N., Gall, S., Gambashidze, K., Gamkrelidze, A., Ganguly, P., Gankpe, F., Gebre, T., Gebrehiwot, T., Gebremedhin, A., Gebru, A., Geleijnse, J., Gessner, B., Ghoshal, A., Gibney, K., Gillum, R., Gilmour, S., Giref, A., Giroud, M., Gishu, M., Giussani, G., Glaser, E., Godwin, W., Gomez-Dantes, H., Gona, P., Goodridge, A., Gopalani, S., Gosselin, R., Gotay, C., Goto, A., Gouda, H., Greaves, F., Gugnani, H., Gupta, R., Gupta, V., Gutierrez, R., Hafezi-Nejad, N., Haile, D., Hailu, A., Hailu, G., Halasa, Y., Hamadeh, R., Hamidi, S., Hancock, J., Handal, A., Hankey, G., Hao, Y., Harb, H., Harikrishnan, S., Haro, J., Havmoeller, R., Heckbert, S., Heredia-Pi, I., Heydarpour, P., Hilderink, H., Hoek, H., Hogg, R., Horino, M., Horita, N., Hosgood, H., Hotez, P., Hoy, D., Hsairi, M., Htet, A., Than Htike, M., Hu, G., Huang, C., Huang, H., Huiart, L., Husseini, A., Huybrechts, I., Huynh, G., Iburg, K., Innos, K., Inoue, M., Iyer, V., Jacobs, T., Jacobsen, K., Jahanmehr, N., Jakovljevic, M., James, P., Javanbakht, M., Jayaraman, S., Jayatilleke, A., Jeemon, P., Jensen, P., Jha, V., Jiang, G., Jiang, Y., Jibat, T., Jimenez-Corona, A., Jonas, J., Joshi, T., Kabir, Z., Karnak, R., Kan, H., Kant, S., Karch, A., Karema, C., Karimkhani, C., Karletsos, D., Karthikeyan, G., Kasaeian, A., Katibeh, M., Kaul, A., Kawakami, N., Kayibanda, J., Keiyoro, P., Kemmer, L., Kemp, A., Kengne, A., Keren, A., Kereselidze, M., Kesavachandran, C., Khader, Y., Khalil, I., Khan, A., Khan, E., Khang, Y., Khera, S., Muthafer Khoja, T., Kieling, C., Kim, D., Kim, Y., Kissela, B., Kissoon, N., Knibbs, L., Knudsen, A., Kokubo, Y., Kolte, D., Kopec, J., Kosen, S., Koul, P., Koyanagi, A., Krog, N., Defo, B., Bicer, B., Kudom, A., Kuipers, E., Kulkarni, V., Kumar, G., Kwan, G., Lal, A., Lal, D., Lalloo, R., Lam, H., Lam, J., Langan, S., Lansingh, V., Larsson, A., Laryea, D., Latif, A., Lawrynowicz, A., Leigh, J., Levi, M., Li, Y., Lindsay, M., Lipshultz, S., Liu, P., Liu, S., Liu, Y., Lo, L., Logroscino, G., Lotufo, P., Lucas, R., Lunevicius, R., Lyons, R., Ma, S., Pedro Machado, V., Mackay, M., MacLachlan, J., Abd El Razek, H., Abd El Razek, M., Majdan, M., Majeed, A., Malekzadeh, R., Ayele Manamo, W., Mandisarisa, J., Mangalam, S., Mapoma, C., Marcenes, W., Margolis, D., Martin, G., Martinez-Raga, J., Marzan, M., Masiye, F., Mason-Jones, A., Massano, J., Matzopoulos, R., Mayosi, B., McGarvey, S., McGrath, J., Mckee, M., McMahon, B., Meaney, P., Mehari, A., Mehndiratta, M., Mena-Rodriguez, F., Mekonnen, A., Melaku, Y., Memiah, P., Memish, Z., Mendoza, W., Meretoja, A., Meretoja, T., Mhimbira, F., Micha, R., Miller, Ted, Mirarefin, M., Misganaw, A., Mock, C., Abdulmuhsin Mohammad, K., Mohammadi, A., Mohammed, S., Mohan, V., Mola, G., Monasta, L., Montanez Hernandez, J., Montero, P., Montico, M., Montine, T., Moradi-Lakeh, M., Morawska, L., Morgan, K., Mori, R., Mozaffarian, D., Mueller, U., Satyanarayana Murthy, G., Murthy, S., Musa, K., Nachega, J., Nagel, G., Naidoo, K., Naik, N., Naldi, L., Nangia, V., Nash, D., Nejjari, C., Neupane, S., Newton, C., Newton, J., Ng, M., Ngalesoni, F., Ngirabega, J., Quyen, L., Nisar, M., Nkamedjie Pete, P., Nomura, M., Norheim, O., Norman, P., Norrving, B., Nyakarahuka, L., Ogbo, F., Ohkubo, T., Ojelabi, F., Olivares, P., Olusanya, B., Olusanya, J., Opio, J., Oren, E., Ortiz, A., Osman, M., Ota, E., Ozdemir, R., Pa, M., Pandian, J., Pant, P., Papachristou, C., Park, E., Park, J., Parry, C., Parsaeian, M., Caicedo, A., Patten, S., Patton, G., Paul, V., Pearce, N., Pedro, J., Stokic, L., Pereira, D., Perico, N., Pesudovs, K., Petzold, M., Phillips, M., Piel, F., Pillay, J., Plass, D., Platts-Mills, J., Polinder, S., Pope, C., Popova, S., Poulton, R., Pourmalek, F., Prabhakaran, D., Qorbani, M., Quame-Amaglo, J., Quistberg, D., Rafay, A., Rahimi, K., Rahimi-Movaghar, V., Rahman, M., Rahman, S., Rai, R., Rajavi, Z., Rajsic, S., Raju, M., Rakovac, I., Rana, S., Ranabhat, C., Rangaswamy, T., Rao, P., Rao, S., Refaat, A., Rehm, J., Reitsma, M., Remuzzi, G., Resnikofff, S., Ribeiro, A., Ricci, S., Blancas, M., Roberts, B., Roca, A., Rojas-Rueda, D., Ronfani, L., Roshandel, G., Rothenbacher, D., Roy, A., Roy, N., Ruhago, G., Sagar, R., Saha, S., Sahathevan, R., Saleh, M., Sanabria, J., Sanchez-Nino, M., Sanchez-Riera, L., Santos, I., Sarmiento-Suarez, R., Sartorius, B., Satpathy, M., Savic, M., Sawhney, M., Schaub, M., Schmidt, M., Schneider, I., Schottker, B., Schutte, A., Schwebel, D., Seedat, S., Sepanlou, S., Servan-Mori, E., Shackelford, K., Shaddick, G., Shaheen, A., Shahraz, S., Shaikh, M., Shakh-Nazarova, M., Sharma, R., She, J., Sheikhbahaei, S., Shen, J., Shen, Z., Shepard, D., Sheth, K., Shetty, B., Shi, P., Shibuya, K., Shin, M., Shiri, R., Shiue, I., Shrime, M., Sigfusdottir, I., Silberberg, D., Silva, D., Silveira, D., Silverberg, J., Simard, E., Singh, A., Singh, G., Singh, J., Singh, O., Singh, P., Singh, V., Soneji, S., Soreide, K., Soriano, J., Sposato, L., Sreeramareddy, C., Stathopoulou, V., Stein, D., Stein, M., Stranges, S., Stroumpoulis, K., Sunguya, B., Sur, P., Swaminathan, S., Sykes, B., Szoeke, C., Tabares-Seisdedos, R., Tabb, K., Takahashi, K., Takala, J., Talongwa, R., Tandon, N., Tavakkoli, M., Taye, B., Taylor, H., Ao, B., Tedla, B., Tefera, W., Ten Have, M., Terkawi, A., Tesfay, F., Tessema, G., Thomson, A., Thorne-Lyman, A., Thrift, A., Thurston, G., Tillmann, T., Tirschwell, D., Tonelli, M., Topor-Madry, R., Topouzis, F., Nx, J., Traebert, J., Tran, B., Truelsen, T., Trujillo, U., Tura, A., Tuzcu, E., Uchendu, U., Ukwaja, K., Undurraga, E., Uthman, O., Van Dingenen, R., Van Donkelaar, A., Vasankari, T., Vasconcelos, A., Venketasubramanian, N., Vidavalur, R., Vijayakumar, L., Villalpando, S., Violante, F., Vlassov, V., Wagner, J., Wagner, G., Wallin, M., Wang, L., Watkins, D., Weichenthal, S., Weiderpass, E., Weintraub, R., Werdecker, A., Westerman, R., White, R., Wijeratne, T., Wilkinson, J., Williams, H., Wiysonge, C., Woldeyohannes, S., Wolfe, C., Won, S., Wong, J., Woolf, A., Xavier, D., Xiao, Q., Xu, G., Yakob, B., Yalew, A., Yan, L., Yano, Y., Yaseri, M., Ye, P., Yebyo, H., Yip, P., Yirsaw, B., Yonemoto, N., Yonga, G., Younis, M., Yu, S., Zaidi, Z., Zaki, M., Zannad, F., Zavala, D., Zeeb, H., Zeleke, B., Zhang, H., Zodpey, S., Zonies, D., Zuhlke, L., Vos, T., Lopez, A., and Murray, C.

Published
2016

240. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

Author

Kassebaum, N., Arora, M., Barber, R., Bhutta, Z., Carter, A., Casey, D., Charlson, F., Coates, M., Coggeshall, M., Cornaby, L., Dandona, L., Dicker, D., Erskine, H., Ferrari, A., Fitzmaurice, C., Foreman, K., Forouzanfar, M., Fullman, N., Gething, P., Goldberg, E., Graetz, N., Haagsma, J., Johnson, C., Kemmer, L., Khalil, I., Kinfu, Y., Kutz, M., Kyu, H., Leung, J., Liang, X., Lim, S., Lozano, R., Mensah, G., Mikesell, J., Mokdad, A., Mooney, M., Naghavi, M., Nguyen, G., Nsoesie, E., Pigott, D., Pinho, C., Rankin, Z., Reinig, N., Salomon, J., Sandar, L., Smith, A., Sorensen, R., Stanaway, J., Steiner, C., Teeple, S., Thomas, B., Troeger, C., VanderZanden, A., Wagner, J., Wanga, V., Whiteford, H., Zhou, M., Zoeckler, L., Abajobir, A., Abate, K., Abbafati, C., Abbas, K., Abd-Allah, F., Abraham, B., Abubakar, I., Abu-Raddad, L., Abu-Rmeileh, N., Achoki, T., Ackerman, I., Adebiyi, A., Adedeji, I., Adsuar, J., Afanvi, K., Afshin, A., Agardh, E., Agarwal, A., Kumar, S., Ahmed, M., Kiadaliri, A., Ahmadieh, H., Akseer, N., Al-Aly, Z., Alam, K., Alam, N., Aldhahri, S., Alegretti, M., Aleman, A., Alemu, Z., Alexander, L., Raghib, A., Alkerwi, A., Alla, F., Allebeck, P., Alsharif, U., Altirkawi, K., Martin, E., Alvis-Guzman, N., Amare, A., Amberbir, A., Amegah, A., Amini, H., Ammar, W., Amrock, S., Anderson, G., Anderson, B., Antonio, C., Anwari, P., Arnlov, J., Arsenijevic, V., Artaman, A., Asayesh, H., Asghar, R., Avokpaho, E., Awasthi, A., Quintanilla, B., Azzopardi, P., Bacha, U., Badawi, A., Balakrishnan, K., Banerjee, A., Barac, A., Barker-Collo, S., Barnighausen, T., Barregard, L., Barrero, L., Basu, S., Bayou, T., Beardsley, J., Bedi, N., Beghi, E., Bell, B., Bell, M., Benjet, C., Bennett, D., Bensenor, I., Berhane, A., Bernabe, E., Betsu, B., Beyene, A., Bhala, N., Bhansali, A., Bhatt, S., Biadgilign, S., Bienhofff, K., Bikbov, B., Bin Abdulhak, A., Bisanzio, D., Bjertness, E., Blore, J., Borschmann, R., Boufous, S., Bourne, R., Brainin, M., Brazinova, A., Breitborde, N., Brugha, T., Buchbinder, R., Buckle, G., Butt, Z., Calabria, B., Campos-Nonato, I., Campuzano, J., Carabin, H., Carapetis, J., Cardenas, R., Carrero, J., Castaneda-Orjuela, C., Rivas, J., Catala-Lopez, F., Cavalleri, F., Chang, J., Chiang, P., Chibalabala, M., Chibueze, C., Chisumpa, V., Choi, J., Choudhury, L., Christensen, H., Ciobanu, L., Colistro, V., Colomar, M., Colquhoun, S., Cortinovis, M., Crump, J., Damasceno, A., Dandona, R., Dargan, P., Das Neves, J., Davey, G., Davis, A., De Leo, D., Degenhardt, L., Del Gobbo, L., Derrett, S., Des Jarlais, D., Deveber, G., Dharmaratne, S., Dhillon, P., Ding, E., Doyle, K., Driscoll, T., Duan, L., Dubey, M., Duncan, B., Ebrahimi, H., Ellenbogen, R., Elyazar, I., Endries, A., Ermakov, S., Eshrati, B., Esteghamati, A., Estep, K., Fahimi, S., Farid, T., Sa Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Feigin, V., Fereshtehnejad, S., Fernandes, J., Fischer, F., Fitchett, J., Foigt, N., Fowkes, F., Franklin, R., Friedman, J., Frostad, J., Furst, T., Futran, N., Gabbe, B., Gankpe, F., Garcia-Basteiro, A., Gebrehiwot, T., Gebremedhin, A., Geleijnse, J., Gibney, K., Gillum, R., Ginawi, I., Giref, A., Giroud, M., Gishu, M., Godwin, W., Gomez-Dantes, H., Gona, P., Goodridge, A., Gopalani, S., Gotay, C., Goto, A., Gouda, H., Guo, Y., Gupta, R., Gupta, V., Gutierrez, R., Hafezi-Nejad, N., Haile, D., Hailu, A., Hailu, G., Halasa, Y., Ribhi, R., Hamadeh, Hamidi, S., Hammami, M., Handal, A., Hankey, G., Harb, H., Harikrishnan, S., Haro, J., Hassanvand, M., Hassen, T., Havmoeller, R., Hay, R., Hedayati, M., Heredia-Pi, I., Heydarpour, P., Hoek, H., Hoffman, D., Horino, M., Horita, N., Hosgood, H., Hoy, D., Hsairi, M., Huang, H., Huang, J., Iburg, K., Idrisov, B., Innos, K., Inoue, M., Jacobsen, K., Jauregui, A., Jayatilleke, A., Jeemon, P., Jha, V., Jiang, G., Jiang, Y., Jibat, T., Jimenez-Corona, A., Jin, Y., Jonas, J., Kabir, Z., Kajungu, D., Kalkonde, Y., Kamal, R., Kan, H., Kandel, A., Karch, A., Karema, C., Karimkhani, C., Kasaeian, A., Katibeh, M., Kaul, A., Kawakami, N., Kazi, D., Keiyoro, P., Kemp, A., Kengne, A., Keren, A., Kesavachandran, C., Khader, Y., Khan, A., Khan, E., Khang, Y., Khoja, T., Khubchandani, J., Kieling, C., Kim, C., Kim, D., Kim, Y., Kissoon, N., Kivipelto, M., Knibbs, L., Knudsen, A., Kokubo, Y., Kolte, D., Kopec, J., Koul, P., Koyanagi, A., Defo, B., Kuchenbecker, R., Bicer, B., Kuipers, E., Kumar, G., Kwan, G., Lalloo, R., Lallukka, T., Larsson, A., Latif, A., Lavados, P., Lawrynowicz, A., Leasher, J., Leigh, J., Leung, R., Li, Y., Lipshultz, S., Liu, P., Liu, Y., Lloyd, B., Logroscino, G., Looker, K., Lotufo, P., Lucas, R., Lunevicius, R., Lyons, R., El Razek, H., Mandavi, M., Majdan, M., Majeed, A., Malekzadeh, R., Malta, D., Marcenes, W., Martinez-Raga, J., Masiye, F., Mason-Jones, A., Matzopoulos, R., Mayosi, B., McGrath, J., Mckee, M., Meaney, P., Mehari, A., Melaku, Y., Memiah, P., Memish, Z., Mendoza, W., Meretoja, A., Meretoja, T., Mesfin, Y., Mhimbira, F., Miller, Ted, Mills, E., Mirarefin, M., Mirrakhimov, E., Mitchell, P., Mock, C., Mohammad, K., Mohammadi, A., Mohammed, S., Monasta, L., Montanez Hernandez, J., Montico, M., Moradi-Lakeh, M., Mori, R., Mueller, U., Mumford, J., Murdoch, M., Murthy, G., Nachega, J., Naheed, A., Naldi, L., Nangia, V., Newton, J., Ng, M., Ngalesoni, F., Le Nguyen, Q., Nisar, M., Pete, P., Nolla, J., Norheim, O., Norman, R., Norrving, B., Obermeyer, C., Ogbo, F., Oh, I., Oladimeji, O., Olivares, P., Olusanya, B., Olusanya, J., Oren, E., Ortiz, A., Ota, E., Oyekale, A., Pa, M., Park, E., Parsaeian, M., Patten, S., Patton, G., Pedro, J., Pereira, D., Perico, N., Pesudovs, K., Petzold, M., Phillips, M., Piel, F., Pillay, J., Pishgar, F., Plass, D., Polinder, S., Popova, S., Poulton, R., Pourmalek, F., Prasad, N., Qorbani, M., Rabiee, R., Radfar, A., Rafay, A., Rahimi, K., Rahimi-Movaghar, V., Rahman, M., Rahman, S., Rai, D., Rai, R., Rajsic, S., Raju, M., Ram, U., Ranganathan, K., Refaat, A., Reitsma, M., Remuzzi, G., Resnikoff, S., Reynolds, A., Ribeiro, A., Ricci, S., Roba, H., Rojas-Rueda, D., Ronfani, L., Roshandel, G., Roth, G., Roy, A., Sackey, B., Sagar, R., Sanabria, J., Dolores Sanchez-Nino, M., Santos, I., Santos, J., Sarmiento-Suarez, R., Sartorius, B., Satpathy, M., Savic, M., Sawhney, M., Schmidt, M., Schneider, I., Schutte, A., Schwebel, D., Seedat, S., Sepanlou, S., Servan-Mori, E., Shahraz, S., Shaikh, M., Sharma, R., She, J., Sheikhbahaei, S., Shen, J., Sheth, K., Shibuya, K., Shigematsu, M., Shin, M., Shin, R., Sigfusdottir, I., Santos Silva, D., Silverberg, J., Simard, E., Singh, A., Singh, J., Singh, P., Skirbekk, V., Skogen, J., Soljak, M., Soreide, K., Sreeramareddy, C., Stathopoulou, V., Steel, N., Stein, D., Stein, M., Steiner, T., Stovner, L., Stranges, S., Stroumpoulis, K., Sunguya, B., Sur, P., Swaminathan, S., Sykes, B., Szoeke, C., Tabares-Seisdedos, R., Landon, N., Tanne, D., Tavakkoli, M., Taye, B., Taylor, H., Ao, B., Tegegne, T., Tekle, D., Terkawi, A., Tessema, G., Thakur, J., Thomson, A., Thorne-Lyman, A., Thrift, A., Thurston, G., Tobe-Gai, R., Tonelli, M., Topor-Madry, R., Topouzis, F., Tran, B., Dimbuene, Z., Tsilimbaris, M., Tura, A., Tuzcu, E., Tyrovolas, S., Ukwaja, K., Undurraga, E., Uneke, C., Uthman, O., van Gool, C., van Os, J., Vasankari, T., Vasconcelos, A., Venketasubramanian, N., Violante, F., Vlassov, V., Vollset, S., Wagner, G., Wallin, M., Wang, L., Weichenthal, S., Weiderpass, E., Weintraub, R., Werdecker, A., WestermaM, R., Wijeratne, T., Wilkinson, J., Williams, H., Wiysonge, C., Woldeyohannes, S., Wolfe, C., Won, S., Xu, G., Yadav, A., Yakob, B., Yan, L., Yan, Y., Yaseri, M., Ye, P., Yip, P., Yonemoto, N., Yoon, S., Younis, M., Yu, C., Zaidi, Z., Zaki, M., Zeeb, H., Zodpey, S., Zonies, D., Zuhlke, L., Vos, T., Lopez, A., Murray, C., Kassebaum, N., Arora, M., Barber, R., Bhutta, Z., Carter, A., Casey, D., Charlson, F., Coates, M., Coggeshall, M., Cornaby, L., Dandona, L., Dicker, D., Erskine, H., Ferrari, A., Fitzmaurice, C., Foreman, K., Forouzanfar, M., Fullman, N., Gething, P., Goldberg, E., Graetz, N., Haagsma, J., Johnson, C., Kemmer, L., Khalil, I., Kinfu, Y., Kutz, M., Kyu, H., Leung, J., Liang, X., Lim, S., Lozano, R., Mensah, G., Mikesell, J., Mokdad, A., Mooney, M., Naghavi, M., Nguyen, G., Nsoesie, E., Pigott, D., Pinho, C., Rankin, Z., Reinig, N., Salomon, J., Sandar, L., Smith, A., Sorensen, R., Stanaway, J., Steiner, C., Teeple, S., Thomas, B., Troeger, C., VanderZanden, A., Wagner, J., Wanga, V., Whiteford, H., Zhou, M., Zoeckler, L., Abajobir, A., Abate, K., Abbafati, C., Abbas, K., Abd-Allah, F., Abraham, B., Abubakar, I., Abu-Raddad, L., Abu-Rmeileh, N., Achoki, T., Ackerman, I., Adebiyi, A., Adedeji, I., Adsuar, J., Afanvi, K., Afshin, A., Agardh, E., Agarwal, A., Kumar, S., Ahmed, M., Kiadaliri, A., Ahmadieh, H., Akseer, N., Al-Aly, Z., Alam, K., Alam, N., Aldhahri, S., Alegretti, M., Aleman, A., Alemu, Z., Alexander, L., Raghib, A., Alkerwi, A., Alla, F., Allebeck, P., Alsharif, U., Altirkawi, K., Martin, E., Alvis-Guzman, N., Amare, A., Amberbir, A., Amegah, A., Amini, H., Ammar, W., Amrock, S., Anderson, G., Anderson, B., Antonio, C., Anwari, P., Arnlov, J., Arsenijevic, V., Artaman, A., Asayesh, H., Asghar, R., Avokpaho, E., Awasthi, A., Quintanilla, B., Azzopardi, P., Bacha, U., Badawi, A., Balakrishnan, K., Banerjee, A., Barac, A., Barker-Collo, S., Barnighausen, T., Barregard, L., Barrero, L., Basu, S., Bayou, T., Beardsley, J., Bedi, N., Beghi, E., Bell, B., Bell, M., Benjet, C., Bennett, D., Bensenor, I., Berhane, A., Bernabe, E., Betsu, B., Beyene, A., Bhala, N., Bhansali, A., Bhatt, S., Biadgilign, S., Bienhofff, K., Bikbov, B., Bin Abdulhak, A., Bisanzio, D., Bjertness, E., Blore, J., Borschmann, R., Boufous, S., Bourne, R., Brainin, M., Brazinova, A., Breitborde, N., Brugha, T., Buchbinder, R., Buckle, G., Butt, Z., Calabria, B., Campos-Nonato, I., Campuzano, J., Carabin, H., Carapetis, J., Cardenas, R., Carrero, J., Castaneda-Orjuela, C., Rivas, J., Catala-Lopez, F., Cavalleri, F., Chang, J., Chiang, P., Chibalabala, M., Chibueze, C., Chisumpa, V., Choi, J., Choudhury, L., Christensen, H., Ciobanu, L., Colistro, V., Colomar, M., Colquhoun, S., Cortinovis, M., Crump, J., Damasceno, A., Dandona, R., Dargan, P., Das Neves, J., Davey, G., Davis, A., De Leo, D., Degenhardt, L., Del Gobbo, L., Derrett, S., Des Jarlais, D., Deveber, G., Dharmaratne, S., Dhillon, P., Ding, E., Doyle, K., Driscoll, T., Duan, L., Dubey, M., Duncan, B., Ebrahimi, H., Ellenbogen, R., Elyazar, I., Endries, A., Ermakov, S., Eshrati, B., Esteghamati, A., Estep, K., Fahimi, S., Farid, T., Sa Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Feigin, V., Fereshtehnejad, S., Fernandes, J., Fischer, F., Fitchett, J., Foigt, N., Fowkes, F., Franklin, R., Friedman, J., Frostad, J., Furst, T., Futran, N., Gabbe, B., Gankpe, F., Garcia-Basteiro, A., Gebrehiwot, T., Gebremedhin, A., Geleijnse, J., Gibney, K., Gillum, R., Ginawi, I., Giref, A., Giroud, M., Gishu, M., Godwin, W., Gomez-Dantes, H., Gona, P., Goodridge, A., Gopalani, S., Gotay, C., Goto, A., Gouda, H., Guo, Y., Gupta, R., Gupta, V., Gutierrez, R., Hafezi-Nejad, N., Haile, D., Hailu, A., Hailu, G., Halasa, Y., Ribhi, R., Hamadeh, Hamidi, S., Hammami, M., Handal, A., Hankey, G., Harb, H., Harikrishnan, S., Haro, J., Hassanvand, M., Hassen, T., Havmoeller, R., Hay, R., Hedayati, M., Heredia-Pi, I., Heydarpour, P., Hoek, H., Hoffman, D., Horino, M., Horita, N., Hosgood, H., Hoy, D., Hsairi, M., Huang, H., Huang, J., Iburg, K., Idrisov, B., Innos, K., Inoue, M., Jacobsen, K., Jauregui, A., Jayatilleke, A., Jeemon, P., Jha, V., Jiang, G., Jiang, Y., Jibat, T., Jimenez-Corona, A., Jin, Y., Jonas, J., Kabir, Z., Kajungu, D., Kalkonde, Y., Kamal, R., Kan, H., Kandel, A., Karch, A., Karema, C., Karimkhani, C., Kasaeian, A., Katibeh, M., Kaul, A., Kawakami, N., Kazi, D., Keiyoro, P., Kemp, A., Kengne, A., Keren, A., Kesavachandran, C., Khader, Y., Khan, A., Khan, E., Khang, Y., Khoja, T., Khubchandani, J., Kieling, C., Kim, C., Kim, D., Kim, Y., Kissoon, N., Kivipelto, M., Knibbs, L., Knudsen, A., Kokubo, Y., Kolte, D., Kopec, J., Koul, P., Koyanagi, A., Defo, B., Kuchenbecker, R., Bicer, B., Kuipers, E., Kumar, G., Kwan, G., Lalloo, R., Lallukka, T., Larsson, A., Latif, A., Lavados, P., Lawrynowicz, A., Leasher, J., Leigh, J., Leung, R., Li, Y., Lipshultz, S., Liu, P., Liu, Y., Lloyd, B., Logroscino, G., Looker, K., Lotufo, P., Lucas, R., Lunevicius, R., Lyons, R., El Razek, H., Mandavi, M., Majdan, M., Majeed, A., Malekzadeh, R., Malta, D., Marcenes, W., Martinez-Raga, J., Masiye, F., Mason-Jones, A., Matzopoulos, R., Mayosi, B., McGrath, J., Mckee, M., Meaney, P., Mehari, A., Melaku, Y., Memiah, P., Memish, Z., Mendoza, W., Meretoja, A., Meretoja, T., Mesfin, Y., Mhimbira, F., Miller, Ted, Mills, E., Mirarefin, M., Mirrakhimov, E., Mitchell, P., Mock, C., Mohammad, K., Mohammadi, A., Mohammed, S., Monasta, L., Montanez Hernandez, J., Montico, M., Moradi-Lakeh, M., Mori, R., Mueller, U., Mumford, J., Murdoch, M., Murthy, G., Nachega, J., Naheed, A., Naldi, L., Nangia, V., Newton, J., Ng, M., Ngalesoni, F., Le Nguyen, Q., Nisar, M., Pete, P., Nolla, J., Norheim, O., Norman, R., Norrving, B., Obermeyer, C., Ogbo, F., Oh, I., Oladimeji, O., Olivares, P., Olusanya, B., Olusanya, J., Oren, E., Ortiz, A., Ota, E., Oyekale, A., Pa, M., Park, E., Parsaeian, M., Patten, S., Patton, G., Pedro, J., Pereira, D., Perico, N., Pesudovs, K., Petzold, M., Phillips, M., Piel, F., Pillay, J., Pishgar, F., Plass, D., Polinder, S., Popova, S., Poulton, R., Pourmalek, F., Prasad, N., Qorbani, M., Rabiee, R., Radfar, A., Rafay, A., Rahimi, K., Rahimi-Movaghar, V., Rahman, M., Rahman, S., Rai, D., Rai, R., Rajsic, S., Raju, M., Ram, U., Ranganathan, K., Refaat, A., Reitsma, M., Remuzzi, G., Resnikoff, S., Reynolds, A., Ribeiro, A., Ricci, S., Roba, H., Rojas-Rueda, D., Ronfani, L., Roshandel, G., Roth, G., Roy, A., Sackey, B., Sagar, R., Sanabria, J., Dolores Sanchez-Nino, M., Santos, I., Santos, J., Sarmiento-Suarez, R., Sartorius, B., Satpathy, M., Savic, M., Sawhney, M., Schmidt, M., Schneider, I., Schutte, A., Schwebel, D., Seedat, S., Sepanlou, S., Servan-Mori, E., Shahraz, S., Shaikh, M., Sharma, R., She, J., Sheikhbahaei, S., Shen, J., Sheth, K., Shibuya, K., Shigematsu, M., Shin, M., Shin, R., Sigfusdottir, I., Santos Silva, D., Silverberg, J., Simard, E., Singh, A., Singh, J., Singh, P., Skirbekk, V., Skogen, J., Soljak, M., Soreide, K., Sreeramareddy, C., Stathopoulou, V., Steel, N., Stein, D., Stein, M., Steiner, T., Stovner, L., Stranges, S., Stroumpoulis, K., Sunguya, B., Sur, P., Swaminathan, S., Sykes, B., Szoeke, C., Tabares-Seisdedos, R., Landon, N., Tanne, D., Tavakkoli, M., Taye, B., Taylor, H., Ao, B., Tegegne, T., Tekle, D., Terkawi, A., Tessema, G., Thakur, J., Thomson, A., Thorne-Lyman, A., Thrift, A., Thurston, G., Tobe-Gai, R., Tonelli, M., Topor-Madry, R., Topouzis, F., Tran, B., Dimbuene, Z., Tsilimbaris, M., Tura, A., Tuzcu, E., Tyrovolas, S., Ukwaja, K., Undurraga, E., Uneke, C., Uthman, O., van Gool, C., van Os, J., Vasankari, T., Vasconcelos, A., Venketasubramanian, N., Violante, F., Vlassov, V., Vollset, S., Wagner, G., Wallin, M., Wang, L., Weichenthal, S., Weiderpass, E., Weintraub, R., Werdecker, A., WestermaM, R., Wijeratne, T., Wilkinson, J., Williams, H., Wiysonge, C., Woldeyohannes, S., Wolfe, C., Won, S., Xu, G., Yadav, A., Yakob, B., Yan, L., Yan, Y., Yaseri, M., Ye, P., Yip, P., Yonemoto, N., Yoon, S., Younis, M., Yu, C., Zaidi, Z., Zaki, M., Zeeb, H., Zodpey, S., Zonies, D., Zuhlke, L., Vos, T., Lopez, A., and Murray, C.

Published
2016

241. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

Author

Forouzanfar, M., Afshin, A., Alexander, L., Anderson, H., Bhutta, Z., Biryukov, S., Brauer, M., Burnett, R., Cercy, K., Charlson, F., Cohen, A., Dandona, L., Estep, K., Ferrari, A., Frostad, J., Fullman, N., Gething, P., Godwin, W., Griswold, M., Kinfu, Y., Kyu, H., Larson, H., Liang, X., Lim, S., Liu, P., Lopez, A., Lozano, R., Marczak, L., Mensah, G., Mokdad, A., Moradi-Lakeh, M., Naghavi, M., Neal, B., Reitsma, M., Roth, G., Salomon, J., Sur, P., Vos, T., Wagner, J., Wang, H., Zhao, Y., Zhou, M., Aasvang, G., Abajobir, A., Abate, K., Abbafati, C., Abbas, K., Abd-Allah, F., Abdulle, A., Abera, S., Abraham, B., Abu-Raddad, L., Abyu, G., Adebiyi, A., Adedeji, I., Ademi, Z., Adou, A., Adsuar, J., Agardh, E., Agarwal, A., Agrawal, A., Kiadaliri, A., Ajala, O., Akinyemiju, T., Al-Aly, Z., Alam, K., Alam, N., Aldhahri, S., Aldridge, R., Alemu, Z., Ali, R., Alkerwi, A., Alla, F., Allebeck, P., Alsharif, U., Altirkawi, K., Alvarez Martin, E., Alvis-Guzman, N., Amare, A., Amberbir, A., Amegah, A., Amini, H., Ammar, W., Amrock, S., Andersen, H., Anderson, B., Antonio, C., Anwar, P., Arnlov, J., Al, A., Asayesh, H., Asghar, R., Assadi, R., Atique, S., Avokpaho, E., Awasthi, A., Quintanilla, B., Azzopardi, P., Bacha, U., Badawi, A., Bahit, M., Balakrishnan, K., Barac, A., Barber, R., Barker-Collo, S., Baernighausen, T., Barquera, S., Barregard, L., Barrero, L., Basu, S., Bans, C., Bazargan-Hejazi, S., Beardsley, J., Bedi, N., Beghi, E., Bell, M., Bello, A., Bennett, D., Bensenor, I., Berhane, A., Bernabe, E., Betsu, B., Beyene, A., Bhala, N., Bhansali, A., Bhatt, S., Biadgilign, S., Bikbov, B., Bisanzio, D., Bjertness, E., Blore, J., Borschmann, R., Boufous, S., Bourne, R., Brainin, M., Brazinova, A., Breitborde, N., Brenner, H., Broday, D., Brugha, T., Brunekreef, B., Butt, Z., Cahill, L., Calabria, B., Ricardo Campos-Nonato, I., Cardenas, R., Carpenter, D., Casey, D., Castaneda-Oquela, C., Castillo Rivas, J., Estanislao Castro, R., Catala-Lopez, F., Chang, J., Chiang, P., Chibalabala, M., Chimed-Ochir, O., Chisumpa, V., Chitheer, A., Choi, J., Christensen, H., Christopher, D., Ciobanu, L., Coates, M., Colquhoun, S., Cooper, L., Cooperrider, K., Cornaby, L., Cortinovis, M., Crump, J., Cuevas-Nasu, L., Damasceno, A., Dandona, R., Darby, S., Dargan, P., das Neves, J., Davis, A., Davletov, K., Filipa de Castro, E., De la Cruz-Gongora, V., De Leo, D., Degenhardt, L., Del Gobbo, L., del Pozo-Cruz, B., Dellavalle, R., Deribew, A., Des Jarlais, D., Dharmaratne, S., Dhillon, P., Diaz-Tome, C., Dicker, D., Ding, E., Dorsey, E., Doyle, K., Driscoll, T., Duan, L., Dubey, M., Duncan, B., Elyazar, I., Endries, A., Ermakov, S., Erskine, H., Eshrati, B., Esteghamati, A., Fahimi, S., Aquino Faraon, E., Farid, T., Sofia E Sa Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Feigin, V., Fereshtehnejad, S., Fernandes, J., Fischer, F., Fitchett, J., Fleming, T., Foigt, N., Foreman, K., Fowkes, F., Franklin, R., Fuerst, T., Futran, N., Gakidou, E., Garcia-Basteiro, A., Gebrehiwot, T., Gebremedhin, A., Geleijnse, J., Gessner, B., Giref, A., Giroud, M., Gishu, M., Goenka, S., Carmen Gomez-Cabrera, M., Gomez-Dantes, H., Gona, P., Goodridge, A., Gopalani, S., Gotay, C., Goto, A., Gouda, H., Gugnani, H., Guillemin, F., Guo, Y., Gupta, R., Gutierrez, R., Haagsma, J., Hafezi-Nejad, N., Haile, D., Hailu, G., Halasa, Y., Hamadeh, R., Hamidi, S., Handal, A., Hankey, G., Hao, Y., Harb, H., Harikrishnan, S., Maria Haro, J., Hassanvand, M., Hassen, T., Havmoeller, R., Beatriz Heredia-Pi, I., Francisco Hernandez-Llanes, N., Heydarpour, P., Hoek, H., Hoffman, H., Horino, M., Horita, N., Hosgood, H., Hoy, D., Hsairi, M., Htet, A., Hu, G., Huang, J., Husseini, A., Hutchings, S., Huybrechts, I., Iburg, K., Idrisov, B., Ileanu, B., Inoue, M., Jacobs, T., Jacobsen, K., Jahanmehr, N., Jakovljevic, M., Jansen, H., Jassal, S., Javanbakht, M., Jayatilleke, A., Jee, S., Jeemon, P., Jha, V., Jiang, Y., Jibat, T., Jin, Y., Johnson, C., Jonas, J., Kabir, Z., Kalkonde, Y., Kamal, R., Kan, H., Karch, A., Karema, C., Karimkhani, C., Kasaeian, A., Kaul, A., Kawakami, N., Kazi, D., Keiyoro, P., Kemp, A., Kengne, A., Keren, A., Kesavachandran, C., Khader, Y., Khan, A., Khan, E., Khan, G., Khang, Y., Khatibzadeh, S., Khera, S., Khoja, T., Khubchandani, J., Kieling, C., Kim, C., Kim, D., Kimokoti, R., Kissoon, N., Kivipelto, M., Knibbs, L., Kokubo, Y., Kopec, J., Koul, P., Koyanagi, A., Kravchenko, M., Kromhout, H., Krueger, H., Ku, T., Defo, B., Kuchenbecker, R., Bicer, B., Kuipers, E., Kumar, G., Kwan, G., Lal, D., Lalloo, R., Lallukka, T., Lan, Q., Larsson, A., Latif, A., Beatriz Lawrynowicz, A., Leasher, J., Leigh, J., Leung, J., Levi, M., Li, X., Li, Y., Liang, J., Liu, S., Lloyd, B., Logroscino, G., Lotufo, P., Lunevicius, R., Maclntyre, M., Mahdavi, M., Majdan, M., Majeed, A., Malekzadeh, R., Malta, D., Manamo, W., Mapoma, C., Marcenes, W., Martin, R., Martinez-Raga, J., Masiye, F., Matsushita, K., Matzopoulos, R., Mayosi, B., McGrath, J., McKee, M., Meaney, P., Medina, C., Mehari, A., Mena-Rodriguez, F., Mekonnen, A., Melaku, Y., Memish, Z., Mendoza, W., Mensink, G., Meretoja, A., Meretoja, T., Mesfin, Y., Mhimbira, F., Miller, Ted, Mills, E., Mirarefin, M., Misganaw, A., Mock, C., Mohammadi, A., Mohammed, S., Mola, G., Monasta, L., Montanez Hernandez, J., Montico, M., Morawska, L., Mori, R., Mozaffarian, D., Mueller, U., Mullany, E., Mumford, J., Murthy, G., Nachega, J., Naheed, A., Nangia, V., Nassiri, N., Newton, J., Ng, M., Quyen, L., Nisar, M., Pete, P., Norheim, O., Norman, R., Norrving, B., Nyakarahuka, L., Obermeyer, C., Ogbo, F., Oh, I., Oladimeji, O., Olivares, P., Olsen, H., Olusanya, B., Olusanya, J., Opio, J., Oren, E., Orozco, R., Ortiz, A., Ota, E., Mahesh, P., Pana, A., Park, E., Parry, C., Parsaeian, M., Patel, T., Caicedo, A., Patil, S., Patten, S., Patton, G., Pearce, N., Pereira, D., Perico, N., Pesudovs, K., Petzold, M., Phillips, M., Piel, F., Pillay, J., Plass, D., Polinder, S., Pond, C., Pope, C., Pope, D., Popova, S., Poulton, R., Pourmalek, F., Prasad, N., Qorbani, M., Rabiee, R., Radfar, A., Rafay, A., Rahimi-Movaghar, V., Rahman, M., Rahman, S., Rai, R., Rajsic, S., Raju, M., Ram, U., Rana, S., Ranganathan, K., Rao, P., Razo Garcia, C., Refaat, A., Rehm, C., Rehm, J., Reinig, N., Remuzzi, G., Resnikoff, S., Ribeiro, A., Rivera, J., Rolm, H., Rodriguez, A., Rodriguez-Ramirez, S., Rojas-Rueda, D., Roman, Y., Ronfani, L., Roshandel, G., Rothenbacher, D., Roy, A., Saleh, M., Sanabria, J., Dolores Sanchez-Nino, M., Sanchez-Pimienta, T., Sandar, L., Santomauro, D., Santos, I., Sarmiento-Suarez, R., Sartorius, B., Satpathy, M., Savic, M., Sawhney, M., Schmidhuber, J., Schmidt, M., Schneider, I., Schoettker, B., Schutte, A., Schwebel, D., Scott, J., Seedat, S., Sepanlou, S., Servan-Mori, E., Shaheen, A., Shahraz, S., Shaikh, M., Levy, T., Sharma, R., She, J., Sheikhbahaei, S., Shen, J., Sheth, K., Shi, P., Shibuya, K., Shigematsu, M., Shin, M., Shiri, R., Shishani, K., Shiue, I., Shrime, M., Sigfusdottir, I., Silva, D., Alves Silveira, D., Silverberg, J., Simard, E., Sindi, S., Singh, A., Singh, J., Singh, P., Slepak, E., Soljak, M., Soneji, S., Sorensen, R., Sposato, L., Sreeramareddy, C., Stathopoulou, V., Steckling, N., Steel, N., Stein, D., Stein, M., Stockl, H., Stranges, S., Stroumpoulis, K., Sunguya, B., Swaminathan, S., Sykes, B., Szoeke, C., Tabares-Seisdedos, R., Takahashi, K., Talongwa, R., Landon, N., Tanne, D., Tavakkoli, M., Taye, B., Taylor, H., Tedla, B., Tefera, W., Tegegne, T., Tekle, D., Terkawi, A., Thakur, J., Thomas, B., Thomas, M., Thomson, A., Thorne-Lyman, A., Thrift, A., Thurston, G., Tillmann, T., Tobe-Gai, R., Tobollik, M., Topor-Madry, R., Topouzis, F., Towbin, J., Bach, X., Dimbuene, Z., Tsilimparis, N., Tura, A., Tuzcu, E., Tyrovolas, S., Ukwaja, K., Undurraga, E., Uneke, C., Uthman, O., van Donkelaar, A., van Os, J., Varakin, Y., Vasankari, T., Veerman, J., Venketasubramanian, N., Violante, F., Vollset, S., Wagner, G., Waller, S., Wang, J., Wang, L., Wang, Y., Weichenthal, S., Weiderpass, E., Weintraub, R., Werdecker, A., Westerman, R., Whiteford, H., Wijeratne, T., Wiysonge, C., Wolfe, C., Won, S., Woolf, A., Wubshet, M., Xavier, D., Xu, G., Yadav, A., Yakob, B., Yalew, A., Yano, Y., Yaseri, M., Ye, P., Yip, P., Yonemoto, N., Yoon, S., Younis, M., Yu, C., Zaidi, Z., Zaki, M., Zhu, J., Zipkin, B., Zodpey, S., Zuhlke, L., Murray, C., Forouzanfar, M., Afshin, A., Alexander, L., Anderson, H., Bhutta, Z., Biryukov, S., Brauer, M., Burnett, R., Cercy, K., Charlson, F., Cohen, A., Dandona, L., Estep, K., Ferrari, A., Frostad, J., Fullman, N., Gething, P., Godwin, W., Griswold, M., Kinfu, Y., Kyu, H., Larson, H., Liang, X., Lim, S., Liu, P., Lopez, A., Lozano, R., Marczak, L., Mensah, G., Mokdad, A., Moradi-Lakeh, M., Naghavi, M., Neal, B., Reitsma, M., Roth, G., Salomon, J., Sur, P., Vos, T., Wagner, J., Wang, H., Zhao, Y., Zhou, M., Aasvang, G., Abajobir, A., Abate, K., Abbafati, C., Abbas, K., Abd-Allah, F., Abdulle, A., Abera, S., Abraham, B., Abu-Raddad, L., Abyu, G., Adebiyi, A., Adedeji, I., Ademi, Z., Adou, A., Adsuar, J., Agardh, E., Agarwal, A., Agrawal, A., Kiadaliri, A., Ajala, O., Akinyemiju, T., Al-Aly, Z., Alam, K., Alam, N., Aldhahri, S., Aldridge, R., Alemu, Z., Ali, R., Alkerwi, A., Alla, F., Allebeck, P., Alsharif, U., Altirkawi, K., Alvarez Martin, E., Alvis-Guzman, N., Amare, A., Amberbir, A., Amegah, A., Amini, H., Ammar, W., Amrock, S., Andersen, H., Anderson, B., Antonio, C., Anwar, P., Arnlov, J., Al, A., Asayesh, H., Asghar, R., Assadi, R., Atique, S., Avokpaho, E., Awasthi, A., Quintanilla, B., Azzopardi, P., Bacha, U., Badawi, A., Bahit, M., Balakrishnan, K., Barac, A., Barber, R., Barker-Collo, S., Baernighausen, T., Barquera, S., Barregard, L., Barrero, L., Basu, S., Bans, C., Bazargan-Hejazi, S., Beardsley, J., Bedi, N., Beghi, E., Bell, M., Bello, A., Bennett, D., Bensenor, I., Berhane, A., Bernabe, E., Betsu, B., Beyene, A., Bhala, N., Bhansali, A., Bhatt, S., Biadgilign, S., Bikbov, B., Bisanzio, D., Bjertness, E., Blore, J., Borschmann, R., Boufous, S., Bourne, R., Brainin, M., Brazinova, A., Breitborde, N., Brenner, H., Broday, D., Brugha, T., Brunekreef, B., Butt, Z., Cahill, L., Calabria, B., Ricardo Campos-Nonato, I., Cardenas, R., Carpenter, D., Casey, D., Castaneda-Oquela, C., Castillo Rivas, J., Estanislao Castro, R., Catala-Lopez, F., Chang, J., Chiang, P., Chibalabala, M., Chimed-Ochir, O., Chisumpa, V., Chitheer, A., Choi, J., Christensen, H., Christopher, D., Ciobanu, L., Coates, M., Colquhoun, S., Cooper, L., Cooperrider, K., Cornaby, L., Cortinovis, M., Crump, J., Cuevas-Nasu, L., Damasceno, A., Dandona, R., Darby, S., Dargan, P., das Neves, J., Davis, A., Davletov, K., Filipa de Castro, E., De la Cruz-Gongora, V., De Leo, D., Degenhardt, L., Del Gobbo, L., del Pozo-Cruz, B., Dellavalle, R., Deribew, A., Des Jarlais, D., Dharmaratne, S., Dhillon, P., Diaz-Tome, C., Dicker, D., Ding, E., Dorsey, E., Doyle, K., Driscoll, T., Duan, L., Dubey, M., Duncan, B., Elyazar, I., Endries, A., Ermakov, S., Erskine, H., Eshrati, B., Esteghamati, A., Fahimi, S., Aquino Faraon, E., Farid, T., Sofia E Sa Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Feigin, V., Fereshtehnejad, S., Fernandes, J., Fischer, F., Fitchett, J., Fleming, T., Foigt, N., Foreman, K., Fowkes, F., Franklin, R., Fuerst, T., Futran, N., Gakidou, E., Garcia-Basteiro, A., Gebrehiwot, T., Gebremedhin, A., Geleijnse, J., Gessner, B., Giref, A., Giroud, M., Gishu, M., Goenka, S., Carmen Gomez-Cabrera, M., Gomez-Dantes, H., Gona, P., Goodridge, A., Gopalani, S., Gotay, C., Goto, A., Gouda, H., Gugnani, H., Guillemin, F., Guo, Y., Gupta, R., Gutierrez, R., Haagsma, J., Hafezi-Nejad, N., Haile, D., Hailu, G., Halasa, Y., Hamadeh, R., Hamidi, S., Handal, A., Hankey, G., Hao, Y., Harb, H., Harikrishnan, S., Maria Haro, J., Hassanvand, M., Hassen, T., Havmoeller, R., Beatriz Heredia-Pi, I., Francisco Hernandez-Llanes, N., Heydarpour, P., Hoek, H., Hoffman, H., Horino, M., Horita, N., Hosgood, H., Hoy, D., Hsairi, M., Htet, A., Hu, G., Huang, J., Husseini, A., Hutchings, S., Huybrechts, I., Iburg, K., Idrisov, B., Ileanu, B., Inoue, M., Jacobs, T., Jacobsen, K., Jahanmehr, N., Jakovljevic, M., Jansen, H., Jassal, S., Javanbakht, M., Jayatilleke, A., Jee, S., Jeemon, P., Jha, V., Jiang, Y., Jibat, T., Jin, Y., Johnson, C., Jonas, J., Kabir, Z., Kalkonde, Y., Kamal, R., Kan, H., Karch, A., Karema, C., Karimkhani, C., Kasaeian, A., Kaul, A., Kawakami, N., Kazi, D., Keiyoro, P., Kemp, A., Kengne, A., Keren, A., Kesavachandran, C., Khader, Y., Khan, A., Khan, E., Khan, G., Khang, Y., Khatibzadeh, S., Khera, S., Khoja, T., Khubchandani, J., Kieling, C., Kim, C., Kim, D., Kimokoti, R., Kissoon, N., Kivipelto, M., Knibbs, L., Kokubo, Y., Kopec, J., Koul, P., Koyanagi, A., Kravchenko, M., Kromhout, H., Krueger, H., Ku, T., Defo, B., Kuchenbecker, R., Bicer, B., Kuipers, E., Kumar, G., Kwan, G., Lal, D., Lalloo, R., Lallukka, T., Lan, Q., Larsson, A., Latif, A., Beatriz Lawrynowicz, A., Leasher, J., Leigh, J., Leung, J., Levi, M., Li, X., Li, Y., Liang, J., Liu, S., Lloyd, B., Logroscino, G., Lotufo, P., Lunevicius, R., Maclntyre, M., Mahdavi, M., Majdan, M., Majeed, A., Malekzadeh, R., Malta, D., Manamo, W., Mapoma, C., Marcenes, W., Martin, R., Martinez-Raga, J., Masiye, F., Matsushita, K., Matzopoulos, R., Mayosi, B., McGrath, J., McKee, M., Meaney, P., Medina, C., Mehari, A., Mena-Rodriguez, F., Mekonnen, A., Melaku, Y., Memish, Z., Mendoza, W., Mensink, G., Meretoja, A., Meretoja, T., Mesfin, Y., Mhimbira, F., Miller, Ted, Mills, E., Mirarefin, M., Misganaw, A., Mock, C., Mohammadi, A., Mohammed, S., Mola, G., Monasta, L., Montanez Hernandez, J., Montico, M., Morawska, L., Mori, R., Mozaffarian, D., Mueller, U., Mullany, E., Mumford, J., Murthy, G., Nachega, J., Naheed, A., Nangia, V., Nassiri, N., Newton, J., Ng, M., Quyen, L., Nisar, M., Pete, P., Norheim, O., Norman, R., Norrving, B., Nyakarahuka, L., Obermeyer, C., Ogbo, F., Oh, I., Oladimeji, O., Olivares, P., Olsen, H., Olusanya, B., Olusanya, J., Opio, J., Oren, E., Orozco, R., Ortiz, A., Ota, E., Mahesh, P., Pana, A., Park, E., Parry, C., Parsaeian, M., Patel, T., Caicedo, A., Patil, S., Patten, S., Patton, G., Pearce, N., Pereira, D., Perico, N., Pesudovs, K., Petzold, M., Phillips, M., Piel, F., Pillay, J., Plass, D., Polinder, S., Pond, C., Pope, C., Pope, D., Popova, S., Poulton, R., Pourmalek, F., Prasad, N., Qorbani, M., Rabiee, R., Radfar, A., Rafay, A., Rahimi-Movaghar, V., Rahman, M., Rahman, S., Rai, R., Rajsic, S., Raju, M., Ram, U., Rana, S., Ranganathan, K., Rao, P., Razo Garcia, C., Refaat, A., Rehm, C., Rehm, J., Reinig, N., Remuzzi, G., Resnikoff, S., Ribeiro, A., Rivera, J., Rolm, H., Rodriguez, A., Rodriguez-Ramirez, S., Rojas-Rueda, D., Roman, Y., Ronfani, L., Roshandel, G., Rothenbacher, D., Roy, A., Saleh, M., Sanabria, J., Dolores Sanchez-Nino, M., Sanchez-Pimienta, T., Sandar, L., Santomauro, D., Santos, I., Sarmiento-Suarez, R., Sartorius, B., Satpathy, M., Savic, M., Sawhney, M., Schmidhuber, J., Schmidt, M., Schneider, I., Schoettker, B., Schutte, A., Schwebel, D., Scott, J., Seedat, S., Sepanlou, S., Servan-Mori, E., Shaheen, A., Shahraz, S., Shaikh, M., Levy, T., Sharma, R., She, J., Sheikhbahaei, S., Shen, J., Sheth, K., Shi, P., Shibuya, K., Shigematsu, M., Shin, M., Shiri, R., Shishani, K., Shiue, I., Shrime, M., Sigfusdottir, I., Silva, D., Alves Silveira, D., Silverberg, J., Simard, E., Sindi, S., Singh, A., Singh, J., Singh, P., Slepak, E., Soljak, M., Soneji, S., Sorensen, R., Sposato, L., Sreeramareddy, C., Stathopoulou, V., Steckling, N., Steel, N., Stein, D., Stein, M., Stockl, H., Stranges, S., Stroumpoulis, K., Sunguya, B., Swaminathan, S., Sykes, B., Szoeke, C., Tabares-Seisdedos, R., Takahashi, K., Talongwa, R., Landon, N., Tanne, D., Tavakkoli, M., Taye, B., Taylor, H., Tedla, B., Tefera, W., Tegegne, T., Tekle, D., Terkawi, A., Thakur, J., Thomas, B., Thomas, M., Thomson, A., Thorne-Lyman, A., Thrift, A., Thurston, G., Tillmann, T., Tobe-Gai, R., Tobollik, M., Topor-Madry, R., Topouzis, F., Towbin, J., Bach, X., Dimbuene, Z., Tsilimparis, N., Tura, A., Tuzcu, E., Tyrovolas, S., Ukwaja, K., Undurraga, E., Uneke, C., Uthman, O., van Donkelaar, A., van Os, J., Varakin, Y., Vasankari, T., Veerman, J., Venketasubramanian, N., Violante, F., Vollset, S., Wagner, G., Waller, S., Wang, J., Wang, L., Wang, Y., Weichenthal, S., Weiderpass, E., Weintraub, R., Werdecker, A., Westerman, R., Whiteford, H., Wijeratne, T., Wiysonge, C., Wolfe, C., Won, S., Woolf, A., Wubshet, M., Xavier, D., Xu, G., Yadav, A., Yakob, B., Yalew, A., Yano, Y., Yaseri, M., Ye, P., Yip, P., Yonemoto, N., Yoon, S., Younis, M., Yu, C., Zaidi, Z., Zaki, M., Zhu, J., Zipkin, B., Zodpey, S., Zuhlke, L., and Murray, C.

Published
2016

242. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015

Author

Miller, Ted, GBD 2015 HIV Collaborators, Wang, H., Wolock, T., Carter, A., Nguyen, G., Kyu, H., Gakidou, E., Hay, S., Mills, E., Trickey, A., Msemburi, W., Coates, M., Mooney, M., Fraser, M., Sligar, A., Salomon, J., Larson, H., Friedman, J., Abajobir, A., Abate, K., Abbas, K., El Razek, M., Abd-Allah, F., Abdulle, A., Abera, S., Abubakr, I., Abu-Raddad, L., Abu-Rmeileh, N., Abyu, G., Adebiyi, A., Adedeji, I., Adelekan, A., Adofo, K., Adou, A., Ajala, O., Akinyemiju, T., Akseer, N., Al Lami, F., Al-Aly, Z., Alam, K., Alam, N., Alsfoor, D., Aldhari, S., Aldridge, R., Alegretti, M., Aleman, A., Alemu, Z., Alfonso-Cristancho, R., Ali, R., Alkerwi, A., Alla, F., Mohammad, R., Al-Raddadi, S., Alsharif, U., Alvarez, E., Alvis-Guzman, N., Amare, A., Amberbir, A., Amegah, A., Ammar, W., Amrock, S., Antonio, C., Anwari, P., Arnlov, J., Artaman, A., Asayesh, H., Asghar, R., Assadi, R., Atique, S., Atkins, L., Avokpaho, E., Aswathi, A., Quintanilla, B., Bacha, U., Badawi, A., Barac, A., Barnighausen, T., Basu, A., Bayou, T., Bayou, Y., Bazargan-Hejazi, S., Beardsley, J., Bedi, N., Bennett, D., Bensenor, I., Betsu, B., Beyene, A., Brainin, M., Brazinova, A., Bretborde, N., Brown, A., Burch, M., Butt, Z., Campuzano, J., Cardenas, R., Carrero, J., Castaneda-Orjuela, C., Rivas, J., Catala-Lopez, F., Chang, H., Chang, J., Chavan, L., Chen, W., Chiang, P., Chibalabala, M., Chisumpa, V., Choi, J., Christopher, D., Ciobanu, L., Cooper, C., Dahiru, T., Damtew, S., Dandona, L., Dandona, R., Neves, J., Jager, P., Leo, D., Degenhardt, L., Deribe, K., Deribew, A., Jarlais, D., Dharmaratne, S., Ding, E., Doshi, P., Driscoll, T., Dubey, M., Elshrek, Y., Elyazar, I., Endries, A., Ermakov, S., Eshrati, B., Esteghamati, A., Faghmous, I., Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Fereshtehnejad, S., Fernandes, J., Fischer, F., Fitchett, J., Foigt, N., Fullman, N., Furst, T., Gankpe, F., Gebre, T., Gebremedhin, A., Gebru, A., Geleijnse, J., Gessner, B., Gething, P., Ghiwot, T., Giroud, M., Gishu, M., Glaser, E., Geonka, S., Goodridge, A., Gopalani, S., Goto, A., Gugnani, H., Guimaraes, M., Gupta, R., Gupta, V., Haagsma, J., Hafezi-Nejad, N., Hagan, H., Hailu, G., Hamadeh, R., Hamidi, S., Hammami, M., Hankey, G., Hao, Y., Harb, H., Harikrishnan, S., Haro, J., Harun, K., Havmoeller, R., Hedayati, M., Heredia-Pi, I., Hoek, H., Horino, M., Horita, N., Hosgood, H., Hoy, D., Hsairi, M., Hu, G., Huang, H., Huang, J., Iburg, K., Idrisov, B., Innos, K., Iyer, V., Miller, Ted, GBD 2015 HIV Collaborators, Wang, H., Wolock, T., Carter, A., Nguyen, G., Kyu, H., Gakidou, E., Hay, S., Mills, E., Trickey, A., Msemburi, W., Coates, M., Mooney, M., Fraser, M., Sligar, A., Salomon, J., Larson, H., Friedman, J., Abajobir, A., Abate, K., Abbas, K., El Razek, M., Abd-Allah, F., Abdulle, A., Abera, S., Abubakr, I., Abu-Raddad, L., Abu-Rmeileh, N., Abyu, G., Adebiyi, A., Adedeji, I., Adelekan, A., Adofo, K., Adou, A., Ajala, O., Akinyemiju, T., Akseer, N., Al Lami, F., Al-Aly, Z., Alam, K., Alam, N., Alsfoor, D., Aldhari, S., Aldridge, R., Alegretti, M., Aleman, A., Alemu, Z., Alfonso-Cristancho, R., Ali, R., Alkerwi, A., Alla, F., Mohammad, R., Al-Raddadi, S., Alsharif, U., Alvarez, E., Alvis-Guzman, N., Amare, A., Amberbir, A., Amegah, A., Ammar, W., Amrock, S., Antonio, C., Anwari, P., Arnlov, J., Artaman, A., Asayesh, H., Asghar, R., Assadi, R., Atique, S., Atkins, L., Avokpaho, E., Aswathi, A., Quintanilla, B., Bacha, U., Badawi, A., Barac, A., Barnighausen, T., Basu, A., Bayou, T., Bayou, Y., Bazargan-Hejazi, S., Beardsley, J., Bedi, N., Bennett, D., Bensenor, I., Betsu, B., Beyene, A., Brainin, M., Brazinova, A., Bretborde, N., Brown, A., Burch, M., Butt, Z., Campuzano, J., Cardenas, R., Carrero, J., Castaneda-Orjuela, C., Rivas, J., Catala-Lopez, F., Chang, H., Chang, J., Chavan, L., Chen, W., Chiang, P., Chibalabala, M., Chisumpa, V., Choi, J., Christopher, D., Ciobanu, L., Cooper, C., Dahiru, T., Damtew, S., Dandona, L., Dandona, R., Neves, J., Jager, P., Leo, D., Degenhardt, L., Deribe, K., Deribew, A., Jarlais, D., Dharmaratne, S., Ding, E., Doshi, P., Driscoll, T., Dubey, M., Elshrek, Y., Elyazar, I., Endries, A., Ermakov, S., Eshrati, B., Esteghamati, A., Faghmous, I., Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Fereshtehnejad, S., Fernandes, J., Fischer, F., Fitchett, J., Foigt, N., Fullman, N., Furst, T., Gankpe, F., Gebre, T., Gebremedhin, A., Gebru, A., Geleijnse, J., Gessner, B., Gething, P., Ghiwot, T., Giroud, M., Gishu, M., Glaser, E., Geonka, S., Goodridge, A., Gopalani, S., Goto, A., Gugnani, H., Guimaraes, M., Gupta, R., Gupta, V., Haagsma, J., Hafezi-Nejad, N., Hagan, H., Hailu, G., Hamadeh, R., Hamidi, S., Hammami, M., Hankey, G., Hao, Y., Harb, H., Harikrishnan, S., Haro, J., Harun, K., Havmoeller, R., Hedayati, M., Heredia-Pi, I., Hoek, H., Horino, M., Horita, N., Hosgood, H., Hoy, D., Hsairi, M., Hu, G., Huang, H., Huang, J., Iburg, K., Idrisov, B., Innos, K., and Iyer, V.

Abstract

Background: Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015. Methods: For countries without high-quality vital registration data, we estimated prevalence and incidence with data from antenatal care clinics and population-based seroprevalence surveys, and with assumptions by age and sex on initial CD4 distribution at infection, CD4 progression rates (probability of progression from higher to lower CD4 cell-count category), on and off antiretroviral therapy (ART) mortality, and mortality from all other causes. Our estimation strategy links the GBD 2015 assessment of all-cause mortality and estimation of incidence and prevalence so that for each draw from the uncertainty distribution all assumptions used in each step are internally consistent. We estimated incidence, prevalence, and death with GBD versions of the Estimation and Projection Package (EPP) and Spectrum software originally developed by the Joint United Nations Programme on HIV/AIDS (UNAIDS). We used an open-source version of EPP and recoded Spectrum for speed, and used updated assumptions from systematic reviews of the literature and GBD demographic data. For countries with high-quality vital registration data, we developed the cohort incidence bias adjustment model to estimate HIV incidence and prevalence largely from the number of deaths caused by HIV recorded in cause-of-death statistics. We corrected these statistics for garbage coding and HIV misclassification.Findings: Global HIV incidence reached its peak in 1997, at 3·3 million new infections (95% uncertainty interval [UI] 3·1–3·4 million). Annual incidence has stayed relatively constant at about 2·6 million per year (range 2·5–2·8 mil

Published
2016

243. Derivation of the mass ratios of 20 new double-lined spectroscopic binaries

Author

Halbwachs, J. -L, Arenou, F., Pourbaix, D., Benoit Famaey, Guillout, P., Lebreton, Y., Salomon, J. -B, Tal-Or, L., Ibata, R., Mazeh, T., Observatoire astronomique de Strasbourg (ObAS), Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université libre de Bruxelles (ULB), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Lebreton, Yveline, and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], [SDU.ASTR] Sciences of the Universe [physics]/Astrophysics [astro-ph], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

247. Masses of the components of SB2 binaries observed withGaia– III. Accurate SB2 orbits for 10 binaries and masses of HIP 87895

Author

Kiefer, F., primary, Halbwachs, J.-L., additional, Arenou, F., additional, Pourbaix, D., additional, Famaey, B., additional, Guillout, P., additional, Lebreton, Y., additional, Nebot Gómez-Morán, A., additional, Mazeh, T., additional, Salomon, J.-B., additional, Soubiran, C., additional, and Tal-Or, L., additional

Published
2016
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250. MLST reveals potentially high-risk international clones of Enterobacter cloacae

Author

Izdebski, R., Baraniak, A., Herda, M., Fiett, J., Bonten, M. J M, Carmeli, Y., Goossens, H., Hryniewicz, W., Brun-buisson, C., Gniadkowski, M., Grabowska, A., Nikonorow, E., Derde, L. P G, Dautzenberg, M. J., Adler, A., Kazma, M., Navon-venezia, S., Malhotra-kumar, S., Lammens, C., Dumpis, U., Giamarellou, H., Muzlovic, I., Nardi, G., Petrikkos, G. L., Stammet, P., Salomon, J., Lawrence, C., Legrand, P., Rossini, A., Salvia, A., Samso, J. Vidal, Fierro, J., Paul, M., Lerman, Y., Izdebski, R., Baraniak, A., Herda, M., Fiett, J., Bonten, M. J M, Carmeli, Y., Goossens, H., Hryniewicz, W., Brun-buisson, C., Gniadkowski, M., Grabowska, A., Nikonorow, E., Derde, L. P G, Dautzenberg, M. J., Adler, A., Kazma, M., Navon-venezia, S., Malhotra-kumar, S., Lammens, C., Dumpis, U., Giamarellou, H., Muzlovic, I., Nardi, G., Petrikkos, G. L., Stammet, P., Salomon, J., Lawrence, C., Legrand, P., Rossini, A., Salvia, A., Samso, J. Vidal, Fierro, J., Paul, M., and Lerman, Y.

Published
2015

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