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4,801 results on '"Russo, F"'

202. P1239: TISLELIZUMAB, A PD-1 INHIBITOR FOR RELAPSED/REFRACTORY MATURE T- AND NK-CELL NEOPLASMS: RESULTS FROM A PHASE 2 STUDY

Author

Bachy, E., primary, Savage, K. J., additional, Huang, H., additional, Kwong, Y. L., additional, Gritti, G., additional, Zhang, Q., additional, Liberati, A. M., additional, Cao, J., additional, Yang, H., additional, Hao, S., additional, Hu, J., additional, Zhou, K., additional, Russo, F., additional, Zhang, H., additional, Sang, W., additional, Ji, J., additional, Ferreri, A. J. M., additional, Damaj, G. L., additional, Liu, H., additional, Zhang, W., additional, Ke, X., additional, Ghiggi, C., additional, Huang, S., additional, Li, X., additional, Yao, H., additional, Paik, J., additional, Novotny, W., additional, Zhou, W., additional, Zhu, H., additional, Huang, J., additional, and Zinzani, P. L., additional

Published
2022
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203. P764: RESPONSE AND SURVIVAL OUTCOMES WITH HYPOMETHYLATING AGENTS IN AN ARGENTINEAN COHORT OF 113 PATIENTS WITH CHRONIC MYELOMONOCITIC LEUKEMIA

Author

Gonzalez, J., primary, Perusini, A., additional, Russo, F., additional, Fuentes, L., additional, Deluca, T., additional, Basquiera, A. L., additional, Navickas, A., additional, Kornblihtt, L., additional, Pintos, N., additional, Nucifora, E., additional, Iastrebner, M., additional, Enrico, A., additional, Arbelbide, J., additional, and Belli, C., additional

Published
2022
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208. Haemodynamic characteristics of COVID-19 patients with acute respiratory distress syndrome requiring mechanical ventilation. An invasive assessment using right heart catheterization

Author

Caravita, S, Baratto, C, Di Marco, F, Calabrese, A, Balestrieri, G, Russo, F, Faini, A, Soranna, D, Perego, G, Badano, L, Grazioli, L, Lorini, F, Parati, G, Senni, M, Caravita S., Baratto C., Di Marco F., Calabrese A., Balestrieri G., Russo F., Faini A., Soranna D., Perego G. B., Badano L, Grazioli L., Lorini F. L., Parati G., Senni M., Caravita, S, Baratto, C, Di Marco, F, Calabrese, A, Balestrieri, G, Russo, F, Faini, A, Soranna, D, Perego, G, Badano, L, Grazioli, L, Lorini, F, Parati, G, Senni, M, Caravita S., Baratto C., Di Marco F., Calabrese A., Balestrieri G., Russo F., Faini A., Soranna D., Perego G. B., Badano L, Grazioli L., Lorini F. L., Parati G., and Senni M.

Abstract

Aims: Interstitial pneumonia due to coronavirus disease 2019 (COVID-19) is often complicated by severe respiratory failure. In addition to reduced lung compliance and ventilation/perfusion mismatch, a blunted hypoxic pulmonary vasoconstriction has been hypothesized, that could explain part of the peculiar pathophysiology of the COVID-19 cardiorespiratory syndrome. However, no invasive haemodynamic characterization of COVID-19 patients has been reported so far. Methods and results: Twenty-one mechanically-ventilated COVID-19 patients underwent right heart catheterization. Their data were compared both with those obtained from non-mechanically ventilated paired control subjects matched for age, sex and body mass index, and with pooled data of 1937 patients with ‘typical’ acute respiratory distress syndrome (ARDS) from a systematic literature review. Cardiac index was higher in COVID-19 patients than in controls [3.8 (2.7–4.5) vs. 2.4 (2.1–2.8) L/min/m2, P < 0.001], but slightly lower than in ARDS patients (P = 0.024). Intrapulmonary shunt and lung compliance were inversely related in COVID-19 patients (r = −0.57, P = 0.011) and did not differ from ARDS patients. Despite this, pulmonary vascular resistance of COVID-19 patients was normal, similar to that of control subjects [1.6 (1.1–2.5) vs. 1.6 (0.9–2.0) WU, P = 0.343], and lower than reported in ARDS patients (P < 0.01). Pulmonary hypertension was present in 76% of COVID-19 patients and in 19% of control subjects (P < 0.001), and it was always post-capillary. Pulmonary artery wedge pressure was higher in COVID-19 than in ARDS patients, and inversely related to lung compliance (r = −0.46, P = 0.038). Conclusions: The haemodynamic profile of COVID-19 patients needing mechanical ventilation is characterized by combined cardiopulmonary alterations. Low pulmonary vascular resistance, coherent with a blunted hypoxic vasoconstriction, is associated with high c

Published
2020

209. Children with special health care needs attending emergency department in Italy: analysis of 3479 cases

Author

Cianci, P, D'Apolito, V, Moretti, A, Barbagallo, M, Paci, S, Carbone, M, Lubrano, R, Urbino, A, Dionisi Vici, C, Memo, L, Zampino, G, La Marca, G, Villani, A, Corsello, G, Selicorni, A, Campania, A, Geremia, C, Castagno, E, Masi, S, Poggi, G, Vestri, M, Fossali, E, Rocchi, A, Dadalt, L, Arrighini, A, Chiappa, S, Renna, S, Piccotti, E, Borgna, C, Govoni, M, Biondi, A, Fossati, C, Iughetti, L, Bertolani, P, Salvatoni, A, Agosti, M, Fuca, F, Ilardi, A, Giuffrida, S, Diguardo, V, Boni, S, D'Antiga, L, Ruggeri, M, Chiaretti, A, Amarri, S, Peduto, A, Bernardi, F, Corsini, I, Deangelis, G, Ruberto, C, Zuccotti, G, Stringhi, C, Lombardi, G, Salladini, C, Dimichele, S, Parola, L, Porta, A, Biasucci, G, Bellini, M, Ortisi, M, Apuril, E, Midulla, F, Tarani, L, Parlapiano, G, Lietti, D, Sforzini, C, Marseglia, G, Savasta, S, Falsaperla, R, Vitaliti, M, Chiarelli, F, Rossi, N, Banderali, G, Giacchero, R, Bernardo, L, Pinto, F, Fabiani, E, Ficcadenti, A, Pellegrini, G, Giacoma, S, Biban, P, Spada, S, Tipo, V, Ghitti, C, Bolognini, S, Mariani, G, Russo, A, Colella, M, Verrico, A, Bruni, P, Poddighe, D, Cagnoli, G, Morandi, F, Gadaleta, A, Barbi, E, Bruno, I, Graziano, R, Sgaramella, P, Catalani, M, Baldoni, I, Colarusso, G, Galvagno, G, Barone, A, Longo, A, Nardella, G, Portale, G, Garigali, G, Bona, G, Erbela, M, Agostiniani, R, Nanni, L, Schieven, E, Dona, M, Varisco, T, Russo, F, Distefano, V, Dipietro, F, Tarallo, L, Imperato, L, Parisi, G, Salzano, R, Raiola, G, Talarico, V, Bellu, R, Cannone, A, Ferrante, P, Cianci P., D'Apolito V., Moretti A., Barbagallo M., Paci S., Carbone M. T., Lubrano R., Urbino A., Dionisi Vici C., Memo L., Zampino G., La Marca G., Villani A., Corsello G., Selicorni A., Campania A., Geremia C., Castagno E., Masi S., Poggi G., Vestri M., Fossali E., Rocchi A., DaDalt L., Arrighini A., Chiappa S., Renna S., Piccotti E., Borgna C., Govoni M. R., Biondi A., Fossati C., Iughetti L., Bertolani P., Salvatoni A., Agosti M., Fuca F., Ilardi A., Giuffrida S., DiGuardo V., Boni S., D'Antiga L., Ruggeri M., Chiaretti A., Amarri S., Peduto A., Bernardi F., Corsini I., DeAngelis G. L., Ruberto C., Zuccotti G. V., Stringhi C., Lombardi G., Salladini C., DiMichele S., Parola L., Porta A., Biasucci G., Bellini M., Ortisi M. T., Apuril E., Midulla F., Tarani L., Parlapiano G., Lietti D., Sforzini C., Marseglia G. L., Savasta S., Falsaperla R., Vitaliti M. C., Chiarelli F., Rossi N., Banderali G., Giacchero R., Bernardo L., Pinto F., Fabiani E., Ficcadenti A., Pellegrini G., Giacoma S., Biban P., Spada S., Tipo V., Ghitti C., Bolognini S., Mariani G., Russo A., Colella M. G., Verrico A., Bruni P., Poddighe D., Cagnoli G., Morandi F., Gadaleta A., Barbi E., Bruno I. I., Graziano R., Sgaramella P., Catalani M. P., Baldoni I., Colarusso G., Galvagno G., Barone A. P., Longo A., Nardella G., Portale G., Garigali G., Bona G., Erbela M., Agostiniani R., Nanni L., Schieven E., Dona M., Varisco T., Russo F., DiStefano V. A., DiPietro F., Tarallo L., Imperato L., Parisi G., Salzano R., Raiola G., Talarico V., Bellu R., Cannone A., Ferrante P., Cianci, P, D'Apolito, V, Moretti, A, Barbagallo, M, Paci, S, Carbone, M, Lubrano, R, Urbino, A, Dionisi Vici, C, Memo, L, Zampino, G, La Marca, G, Villani, A, Corsello, G, Selicorni, A, Campania, A, Geremia, C, Castagno, E, Masi, S, Poggi, G, Vestri, M, Fossali, E, Rocchi, A, Dadalt, L, Arrighini, A, Chiappa, S, Renna, S, Piccotti, E, Borgna, C, Govoni, M, Biondi, A, Fossati, C, Iughetti, L, Bertolani, P, Salvatoni, A, Agosti, M, Fuca, F, Ilardi, A, Giuffrida, S, Diguardo, V, Boni, S, D'Antiga, L, Ruggeri, M, Chiaretti, A, Amarri, S, Peduto, A, Bernardi, F, Corsini, I, Deangelis, G, Ruberto, C, Zuccotti, G, Stringhi, C, Lombardi, G, Salladini, C, Dimichele, S, Parola, L, Porta, A, Biasucci, G, Bellini, M, Ortisi, M, Apuril, E, Midulla, F, Tarani, L, Parlapiano, G, Lietti, D, Sforzini, C, Marseglia, G, Savasta, S, Falsaperla, R, Vitaliti, M, Chiarelli, F, Rossi, N, Banderali, G, Giacchero, R, Bernardo, L, Pinto, F, Fabiani, E, Ficcadenti, A, Pellegrini, G, Giacoma, S, Biban, P, Spada, S, Tipo, V, Ghitti, C, Bolognini, S, Mariani, G, Russo, A, Colella, M, Verrico, A, Bruni, P, Poddighe, D, Cagnoli, G, Morandi, F, Gadaleta, A, Barbi, E, Bruno, I, Graziano, R, Sgaramella, P, Catalani, M, Baldoni, I, Colarusso, G, Galvagno, G, Barone, A, Longo, A, Nardella, G, Portale, G, Garigali, G, Bona, G, Erbela, M, Agostiniani, R, Nanni, L, Schieven, E, Dona, M, Varisco, T, Russo, F, Distefano, V, Dipietro, F, Tarallo, L, Imperato, L, Parisi, G, Salzano, R, Raiola, G, Talarico, V, Bellu, R, Cannone, A, Ferrante, P, Cianci P., D'Apolito V., Moretti A., Barbagallo M., Paci S., Carbone M. T., Lubrano R., Urbino A., Dionisi Vici C., Memo L., Zampino G., La Marca G., Villani A., Corsello G., Selicorni A., Campania A., Geremia C., Castagno E., Masi S., Poggi G., Vestri M., Fossali E., Rocchi A., DaDalt L., Arrighini A., Chiappa S., Renna S., Piccotti E., Borgna C., Govoni M. R., Biondi A., Fossati C., Iughetti L., Bertolani P., Salvatoni A., Agosti M., Fuca F., Ilardi A., Giuffrida S., DiGuardo V., Boni S., D'Antiga L., Ruggeri M., Chiaretti A., Amarri S., Peduto A., Bernardi F., Corsini I., DeAngelis G. L., Ruberto C., Zuccotti G. V., Stringhi C., Lombardi G., Salladini C., DiMichele S., Parola L., Porta A., Biasucci G., Bellini M., Ortisi M. T., Apuril E., Midulla F., Tarani L., Parlapiano G., Lietti D., Sforzini C., Marseglia G. L., Savasta S., Falsaperla R., Vitaliti M. C., Chiarelli F., Rossi N., Banderali G., Giacchero R., Bernardo L., Pinto F., Fabiani E., Ficcadenti A., Pellegrini G., Giacoma S., Biban P., Spada S., Tipo V., Ghitti C., Bolognini S., Mariani G., Russo A., Colella M. G., Verrico A., Bruni P., Poddighe D., Cagnoli G., Morandi F., Gadaleta A., Barbi E., Bruno I. I., Graziano R., Sgaramella P., Catalani M. P., Baldoni I., Colarusso G., Galvagno G., Barone A. P., Longo A., Nardella G., Portale G., Garigali G., Bona G., Erbela M., Agostiniani R., Nanni L., Schieven E., Dona M., Varisco T., Russo F., DiStefano V. A., DiPietro F., Tarallo L., Imperato L., Parisi G., Salzano R., Raiola G., Talarico V., Bellu R., Cannone A., and Ferrante P.

Abstract

Background: Although children with special health care needs (CSHCN) represent a minority of the population, they go through more hospitalizations, more admissions to the Emergency Department (ED), and receive a major number of medical prescriptions, in comparison to general pediatric population. Objectives of the study were to determine the reasons for admission to the ED in Italian CSHCN, and to describe the association between patient’s demographic data, clinical history, and health services requirements. Methods: Ad hoc web site was created to collect retrospective data of 3479 visits of CSHCN to the ED in 58 Italian Hospitals. Results: Seventy-two percent of patients admitted to ED were affected by a previously defined medical condition. Most of the ED admissions were children with syndromic conditions (54%). 44.2% of the ED admissions were registered during the night-time and/or at the weekends. The hospitalization rate was of 45.6% among patients admitted to the ED. The most common reason for admission to the ED was the presence of respiratory symptoms (26.6%), followed by gastrointestinal problems (21.3%) and neurological disorders (18.2%). 51.4% of the access were classified as ‘urgent’, with a red/yellow triage code. Considering the type of ED, 61.9% of the visits were conducted at the Pediatric EDs (PedEDs), 33.5% at the Functional EDs (FunEDs) and 4.6% at the Dedicated EDs (DedEDs). Patients with more complex clinical presentation were more likely to be evaluated at the PedEDs. CSHCN underwent to a higher number of medical procedures at the PedEDs, more in comparison to other EDs. Children with medical devices were directed to a PedED quite exclusively when in need for medical attention. Subjects under multiple anti-epileptic drug therapy attended to PedEDs or FunEDs generally. Patients affected by metabolic diseases were more likely to look for medical attention at FunEDs. Syndromic patients mostly required medical attention at the DedEDs. Conclusions

Published
2020

210. The identification problem for BSDEs driven by possibly non-quasi-left-continuous random measures

Author

Bandini, E, Russo, F, Bandini E., Russo F., Bandini, E, Russo, F, Bandini E., and Russo F.

Abstract

In this paper, we focus on the so-called identification problem for a BSDE driven by a continuous local martingale and a possibly non-quasi-left-continuous random measure. Supposing that a solution (Y,Z,U) of a BSDE is such that Yt = v(t,Xt), where X is an underlying process and v is a deterministic function, solving the identification problem consists in determining Z and U in terms of v. We study the over-mentioned identification problem under various sets of assumptions and we provide a family of examples including the case when X is a non-semimartingale jump process solution of an SDE with singular coefficients.

Published
2020

211. Long-term impact of preventive UDCA therapy after transplantation for primary biliary cholangitis

Author

Corpechot, C, Chazouilleres, O, Belnou, P, Montano-Loza, A, Mason, A, Ebadi, M, Eurich, D, Chopra, S, Jacob, D, Schramm, C, Sterneck, M, Bruns, T, Reuken, P, Rauchfuss, F, Roccarina, D, Thorburn, D, Gerussi, A, Trivedi, P, Hirschfield, G, Mcdowell, P, Nevens, F, Boillot, O, Bosch, A, Giostra, E, Conti, F, Poupon, R, Pares, A, Reig, A, Donato, M, Malinverno, F, Floreani, A, Russo, F, Cazzagon, N, Verhelst, X, Goet, J, Harms, M, van Buuren, H, Hansen, B, Carrat, F, Dumortier, J, Corpechot C., Chazouilleres O., Belnou P., Montano-Loza A. J., Mason A., Ebadi M., Eurich D., Chopra S., Jacob D., Schramm C., Sterneck M., Bruns T., Reuken P., Rauchfuss F., Roccarina D., Thorburn D., Gerussi A., Trivedi P., Hirschfield G., McDowell P., Nevens F., Boillot O., Bosch A., Giostra E., Conti F., Poupon R., Pares A., Reig A., Donato M. F., Malinverno F., Floreani A., Russo F. P., Cazzagon N., Verhelst X., Goet J., Harms M., van Buuren H., Hansen B., Carrat F., Dumortier J., Corpechot, C, Chazouilleres, O, Belnou, P, Montano-Loza, A, Mason, A, Ebadi, M, Eurich, D, Chopra, S, Jacob, D, Schramm, C, Sterneck, M, Bruns, T, Reuken, P, Rauchfuss, F, Roccarina, D, Thorburn, D, Gerussi, A, Trivedi, P, Hirschfield, G, Mcdowell, P, Nevens, F, Boillot, O, Bosch, A, Giostra, E, Conti, F, Poupon, R, Pares, A, Reig, A, Donato, M, Malinverno, F, Floreani, A, Russo, F, Cazzagon, N, Verhelst, X, Goet, J, Harms, M, van Buuren, H, Hansen, B, Carrat, F, Dumortier, J, Corpechot C., Chazouilleres O., Belnou P., Montano-Loza A. J., Mason A., Ebadi M., Eurich D., Chopra S., Jacob D., Schramm C., Sterneck M., Bruns T., Reuken P., Rauchfuss F., Roccarina D., Thorburn D., Gerussi A., Trivedi P., Hirschfield G., McDowell P., Nevens F., Boillot O., Bosch A., Giostra E., Conti F., Poupon R., Pares A., Reig A., Donato M. F., Malinverno F., Floreani A., Russo F. P., Cazzagon N., Verhelst X., Goet J., Harms M., van Buuren H., Hansen B., Carrat F., and Dumortier J.

Abstract

Background & Aims: Recurrence of primary biliary cholangitis (PBC) after liver transplantation (LT) is frequent and can impair graft and patient survival. Ursodeoxycholic acid (UDCA) is the current standard therapy for PBC. We investigated the effect of preventive exposure to UDCA on the incidence and long-term consequences of PBC recurrence after LT. Methods: We performed a retrospective cohort study in 780 patients transplanted for PBC, between 1983–2017 in 16 centers (9 countries), and followed-up for a median of 11 years. Among them, 190 received preventive UDCA (10–15 mg/kg/day). The primary outcome was histological evidence of PBC recurrence. The secondary outcomes were graft loss, liver-related death, and all-cause death. The association between preventive UDCA and outcomes was quantified using multivariable-adjusted Cox and restricted mean survival time (RMST) models. Results: While recurrence of PBC significantly shortened graft and patient survival, preventive exposure to UDCA was associated with reduced risk of PBC recurrence (adjusted hazard ratio [aHR] 0.41; 95% CI 0.28–0.61; p <0.0001), graft loss (aHR 0.33; 95% CI 0.13–0.82; p <0.05), liver-related death (aHR 0.46; 95% CI 0.22–0.98; p <0.05), and all-cause death (aHR 0.69; 95% CI 0.49–0.96; p <0.05). On RMST analysis, preventive UDCA led to a survival gain of 2.26 years (95% CI 1.28–3.25) over a period of 20 years. Exposure to cyclosporine rather than tacrolimus had a complementary protective effect alongside preventive UDCA, reducing the cumulative incidence of PBC recurrence and all-cause death. Conclusions: Preventive UDCA after LT for PBC is associated with a reduced risk of disease recurrence, graft loss, and death. A regimen combining cyclosporine and preventive UDCA is associated with the lowest risk of PBC recurrence and mortality. Lay summary: Recurrence of primary biliary cholangitis after liver transplantation is frequent and can impair graft and patient survival. We perform

Published
2020

212. Pearl and pitfalls in brain functional analysis by event-related potentials: a narrative review by the Italian Psychophysiology and Cognitive Neuroscience Society on methodological limits and clinical reliability—part II

Author

de Tommaso, M, Betti, V, Bocci, T, Bolognini, N, Di Russo, F, Fattapposta, F, Ferri, R, Invitto, S, Koch, G, Miniussi, C, Piccione, F, Ragazzoni, A, Sartucci, F, Rossi, S, Valeriani, M, de Tommaso M., Betti V., Bocci T., Bolognini N., Di Russo F., Fattapposta F., Ferri R., Invitto S., Koch G., Miniussi C., Piccione F., Ragazzoni A., Sartucci F., Rossi S., Valeriani M., de Tommaso, M, Betti, V, Bocci, T, Bolognini, N, Di Russo, F, Fattapposta, F, Ferri, R, Invitto, S, Koch, G, Miniussi, C, Piccione, F, Ragazzoni, A, Sartucci, F, Rossi, S, Valeriani, M, de Tommaso M., Betti V., Bocci T., Bolognini N., Di Russo F., Fattapposta F., Ferri R., Invitto S., Koch G., Miniussi C., Piccione F., Ragazzoni A., Sartucci F., Rossi S., and Valeriani M.

Abstract

This review focuses on new and/or less standardized event-related potentials methods, in order to improve their knowledge for future clinical applications. The olfactory event-related potentials (OERPs) assess the olfactory functions in time domain, with potential utility in anosmia and degenerative diseases. The transcranial magnetic stimulation-electroencephalography (TMS-EEG) could support the investigation of the intracerebral connections with very high temporal discrimination. Its application in the diagnosis of disorders of consciousness has achieved recent confirmation. Magnetoencephalography (MEG) and event-related fields (ERF) could improve spatial accuracy of scalp signals, with potential large application in pre-surgical study of epileptic patients. Although these techniques have methodological limits, such as high inter- and intraindividual variability and high costs, their diffusion among researchers and clinicians is hopeful, pending their standardization.

Published
2020

213. Introducing the CTA concept

Author

Acharya, B.S., Actis, M., Aghajani, T., Agnetta, G., Aguilar, J., Aharonian, F., Ajello, M., Akhperjanian, A., Alcubierre, M., Aleksić, J., Alfaro, R., Aliu, E., Allafort, A.J., Allan, D., Allekotte, I., Amato, E., Anderson, J., Angüner, E.O., Antonelli, L.A., Antoranz, P., Aravantinos, A., Arlen, T., Armstrong, T., Arnaldi, H., Arrabito, L., Asano, K., Ashton, T., Asorey, H.G., Awane, Y., Baba, H., Babic, A., Baby, N., Bähr, J., Bais, A., Baixeras, C., Bajtlik, S., Balbo, M., Balis, D., Balkowski, C., Bamba, A., Bandiera, R., Barber, A., Barbier, C., Barceló, M., Barnacka, A., Barnstedt, J., Barres de Almeida, U., Barrio, J.A., Basili, A., Basso, S., Bastieri, D., Bauer, C., Baushev, A., Becerra, J., Becherini, Y., Bechtol, K.C., Becker Tjus, J., Beckmann, V., Bednarek, W., Behera, B., Belluso, M., Benbow, W., Berdugo, J., Berger, K., Bernard, F., Bernardino, T., Bernlöhr, K., Bhat, N., Bhattacharyya, S., Bigongiari, C., Biland, A., Billotta, S., Bird, T., Birsin, E., Bissaldi, E., Biteau, J., Bitossi, M., Blake, S., Blanch Bigas, O., Blasi, P., Bobkov, A., Boccone, V., Boettcher, M., Bogacz, L., Bogart, J., Bogdan, M., Boisson, C., Boix Gargallo, J., Bolmont, J., Bonanno, G., Bonardi, A., Bonev, T., Bonifacio, P., Bonnoli, G., Bordas, P., Borgland, A., Borkowski, J., Bose, R., Botner, O., Bottani, A., Bouchet, L., Bourgeat, M., Boutonnet, C., Bouvier, A., Brau-Nogué, S., Braun, I., Bretz, T., Briggs, M., Bringmann, T., Brook, P., Brun, P., Brunetti, L., Buanes, T., Buckley, J., Buehler, R., Bugaev, V., Bulgarelli, A., Bulik, T., Busetto, G., Buson, S., Byrum, K., Cailles, M., Cameron, R., Camprecios, J., Canestrari, R., Cantu, S., Capalbi, M., Caraveo, P., Carmona, E., Carosi, A., Carr, J., Carton, P.-H., Casanova, S., Casiraghi, M., Catalano, O., Cavazzani, S., Cazaux, S., Cerruti, M., Chabanne, E., Chadwick, P., Champion, C., Chen, A., Chiang, J., Chiappetti, L., Chikawa, M., Chitnis, V.R., Chollet, F., Chudoba, J., Cieślar, M., Cillis, A., Cohen-Tanugi, J., Colafrancesco, S., Colin, P., Colome, J., Colonges, S., Compin, M., Conconi, P., Conforti, V., Connaughton, V., Conrad, J., Contreras, J.L., Coppi, P., Corona, P., Corti, D., Cortina, J., Cossio, L., Costantini, H., Cotter, G., Courty, B., Couturier, S., Covino, S., Crimi, G., Criswell, S.J., Croston, J., Cusumano, G., Dafonseca, M., Dale, O., Daniel, M., Darling, J., Davids, I., Dazzi, F., De Angelis, A., De Caprio, V., De Frondat, F., de Gouveia Dal Pino, E.M., de la Calle, I., De La Vega, G.A., de los Reyes Lopez, R., De Lotto, B., De Luca, A., de Mello Neto, J.R.T., de Naurois, M., de Oliveira, Y., de Oña Wilhelmi, E., de Souza, V., Decerprit, G., Decock, G., Deil, C., Delagnes, E., Deleglise, G., Delgado, C., Della Volpe, D., Demange, P., Depaola, G., Dettlaff, A., Di Paola, A., Di Pierro, F., Díaz, C., Dick, J., Dickherber, R., Dickinson, H., Diez-Blanco, V., Digel, S., Dimitrov, D., Disset, G., Djannati-Ataï, A., Doert, M., Dohmke, M., Domainko, W., Dominis Prester, D., Donat, 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Y., Gámez-García, J., García, B., Garcia López, R., Gardiol, D., Garrido, D., Garrido, L., Gascon, D., Gaug, M., Gaweda, J., Gebremedhin, L., Geffroy, N., Gerard, L., Ghedina, A., Ghigo, M., Giannakaki, E., Gianotti, F., Giarrusso, S., Giavitto, G., Giebels, B., Gika, V., Giommi, P., Girard, N., Giro, E., Giuliani, A., Glanzman, T., Glicenstein, J.-F., Godinovic, N., Golev, V., Gomez Berisso, M., Gómez-Ortega, J., Gonzalez, M.M., González, A., González, F., González Muñoz, A., Gothe, K.S., Gougerot, M., Graciani, R., Grandi, P., Grañena, F., Granot, J., Grasseau, G., Gredig, R., Green, A., Greenshaw, T., Grégoire, T., Grimm, O., Grube, J., Grudzinska, M., Gruev, V., Grünewald, S., Grygorczuk, J., Guarino, V., Gunji, S., Gyuk, G., Hadasch, D., Hagiwara, R., Hahn, J., Hakansson, N., Hallgren, A., Hamer Heras, N., Hara, S., Hardcastle, M.J., Harris, J., Hassan, T., Hatanaka, K., Haubold, T., Haupt, A., Hayakawa, T., Hayashida, M., Heller, R., Henault, F., Henri, G., Hermann, G., Hermel, R., Herrero, A., Hidaka, N., Hinton, J., Hoffmann, D., Hofmann, W., Hofverberg, P., Holder, J., Horns, D., Horville, D., Houles, J., Hrabovsky, M., Hrupec, D., Huan, H., Huber, B., Huet, J.-M., Hughes, G., Humensky, T.B., Huovelin, J., Ibarra, A., Illa, J.M., Impiombato, D., Incorvaia, S., Inoue, S., Inoue, Y., Ioka, K., Ismailova, E., Jablonski, C., Jacholkowska, A., Jamrozy, M., Janiak, M., Jean, P., Jeanney, C., Jimenez, J.J., Jogler, T., Johnson, T., Journet, L., Juffroy, C., Jung, I., Kaaret, P., Kabuki, S., Kagaya, M., Kakuwa, J., Kalkuhl, C., Kankanyan, R., Karastergiou, A., Kärcher, K., Karczewski, M., Karkar, S., Kasperek, J., Kastana, D., Katagiri, H., Kataoka, J., Katarzyński, K., Katz, U., Kawanaka, N., Kellner-Leidel, B., Kelly, H., Kendziorra, E., Khélifi, B., Kieda, D.B., Kifune, T., Kihm, T., Kishimoto, T., Kitamoto, K., Kluźniak, W., Knapic, C., Knapp, J., Knödlseder, J., Köck, F., Kocot, J., Kodani, K., Köhne, J.-H., Kohri, K., Kokkotas, K., Kolitzus, D., Komin, N., Kominis, I., Konno, Y., Köppel, H., Korohoda, P., Kosack, K., Koss, G., Kossakowski, R., Kostka, P., Koul, R., Kowal, G., Koyama, S., Kozioł, J., Krähenbühl, T., Krause, J., Krawzcynski, H., Krennrich, F., Krepps, A., Kretzschmann, A., Krobot, R., Krueger, P., Kubo, H., Kudryavtsev, V.A., Kushida, J., Kuznetsov, A., La Barbera, A., La Palombara, N., La Parola, V., La Rosa, G., Lacombe, K., Lamanna, G., Lande, J., Languignon, D., Lapington, J., Laporte, P., Lavalley, C., Le Flour, T., Le Padellec, A., Lee, S.-H., Lee, W.H., Leigui de Oliveira, M.A., Lelas, D., Lenain, J.-P., Leopold, D.J., Lerch, T., Lessio, L., Lieunard, B., Lindfors, E., Liolios, A., Lipniacka, A., Lockart, H., Lohse, T., Lombardi, S., Lopatin, A., Lopez, M., López-Coto, R., López-Oramas, A., Lorca, A., Lorenz, E., Lubinski, P., Lucarelli, F., Lüdecke, H., Ludwin, J., Luque-Escamilla, P.L., Lustermann, W., Luz, O., Lyard, E., Maccarone, M.C., Maccarone, T.J., Madejski, G.M., Madhavan, A., Mahabir, M., Maier, G., Majumdar, P., Malaguti, G., Maltezos, S., Manalaysay, A., Mancilla, A., Mandat, D., Maneva, G., Mangano, A., Manigot, P., Mannheim, K., Manthos, I., Maragos, N., Marcowith, A., Mariotti, M., Marisaldi, M., Markoff, S., Marszałek, A., Martens, C., Martí, J., Martin, J.-M., Martin, P., Martínez, G., Martínez, F., Martínez, M., Masserot, A., Mastichiadis, A., Mathieu, A., Matsumoto, H., Mattana, F., Mattiazzo, S., Maurin, G., Maxfield, S., Maya, J., Mazin, D., Mc Comb, L., McCubbin, N., McHardy, I., McKay, R., Medina, C., Melioli, C., Melkumyan, D., Mereghetti, S., Mertsch, P., Meucci, M., Michałowski, J., Micolon, P., Mihailidis, A., Mineo, T., Minuti, M., Mirabal, N., Mirabel, F., Miranda, J.M., Mirzoyan, R., Mizuno, T., Moal, B., Moderski, R., Mognet, I., Molinari, E., Molinaro, M., Montaruli, T., Monteiro, I., Moore, P., Moralejo Olaizola, A., Mordalska, M., Morello, C., Mori, K., Mottez, F., Moudden, Y., Moulin, E., Mrusek, I., Mukherjee, R., Munar-Adrover, P., Muraishi, H., Murase, K., Murphy, A., Nagataki, S., Naito, T., Nakajima, D., Nakamori, T., Nakayama, K., Naumann, C., Naumann, D., Naumann-Godo, M., Nayman, P., Nedbal, D., Neise, D., Nellen, L., Neustroev, V., Neyroud, N., Nicastro, L., Nicolau-Kukliński, J., Niedźwiecki, A., Niemiec, J., Nieto, D., Nikolaidis, A., Nishijima, K., Nolan, S., Northrop, R., Nosek, D., Nowak, N., Nozato, A., O’Brien, P., Ohira, Y., Ohishi, M., Ohm, S., Ohoka, H., Okuda, T., Okumura, A., Olive, J.-F., Ong, R.A., Orito, R., Orr, M., Osborne, J., Ostrowski, M., Otero, L.A., Otte, N., Ovcharov, E., Oya, I., Ozieblo, A., Padilla, L., Paiano, S., Paillot, D., Paizis, A., Palanque, S., Palatka, M., Pallota, J., Panagiotidis, K., Panazol, J.-L., Paneque, D., Panter, M., Paoletti, R., Papayannis, A., Papyan, G., Paredes, J.M., Pareschi, G., Parks, G., Parraud, J.-M., Parsons, D., Paz Arribas, M., Pech, M., Pedaletti, G., Pelassa, V., Pelat, D., Perez, M.d.C., Persic, M., Petrucci, P.-O., Peyaud, B., Pichel, A., Pita, S., Pizzolato, F., Platos, Ł., Platzer, R., Pogosyan, L., Pohl, M., Pojmanski, G., Ponz, J.D., Potter, W., Poutanen, J., Prandini, E., Prast, J., Preece, R., Profeti, F., Prokoph, H., Prouza, M., Proyetti, M., Puerto-Gimenez, I., Pühlhofer, G., Puljak, I., Punch, M., Pyzioł, R., Quel, E.J., Quinn, J., Quirrenbach, A., Racero, E., Rajda, P.J., Ramon, P., Rando, R., Rannot, R.C., Rataj, M., Raue, M., Reardon, P., Reimann, O., Reimer, A., Reimer, O., Reitberger, K., Renaud, M., Renner, S., Reville, B., Rhode, W., Ribó, M., Ribordy, M., Richer, M.G., Rico, J., Ridky, J., Rieger, F., Ringegni, P., Ripken, J., Ristori, P.R., Riviére, A., Rivoire, S., Rob, L., Roeser, U., Rohlfs, R., Rojas, G., Romano, P., Romaszkan, W., Romero, G.E., Rosen, S., Rosier Lees, S., Ross, D., Rouaix, G., Rousselle, J., Rousselle, S., Rovero, A.C., Roy, F., Royer, S., Rudak, B., Rulten, C., Rupiński, M., Russo, F., Ryde, F., Sacco, B., Saemann, E.O., Saggion, A., Sahakian, V., Saito, K., Saito, T., Saito, Y., Sakaki, N., Sakonaka, R., Salini, A., Sanchez, F., Sanchez-Conde, M., Sandoval, A., Sandaker, H., Sant’Ambrogio, E., Santangelo, A., Santos, E.M., Sanuy, A., Sapozhnikov, L., Sarkar, S., Sartore, N., Sasaki, H., Satalecka, K., Sawada, M., Scalzotto, V., Scapin, V., Scarcioffolo, M., Schafer, J., Schanz, T., Schlenstedt, S., Schlickeiser, R., Schmidt, T., Schmoll, J., Schovanek, P., Schroedter, M., Schultz, C., Schultze, J., Schulz, A., Schure, K., Schwab, T., Schwanke, U., Schwarz, J., Schwarzburg, S., Schweizer, T., Schwemmer, S., Segreto, A., Seiradakis, J.-H., Sembroski, G.H., Seweryn, K., Sharma, M., Shayduk, M., Shellard, R.C., Shi, J., Shibata, T., Shibuya, A., Shum, E., Sidoli, L., Sidz, M., Sieiro, J., Sikora, M., Silk, J., Sillanpää, A., Singh, B.B., Sitarek, J., Skole, C., Smareglia, R., Smith, A., Smith, D., Smith, J., Smith, N., Sobczyńska, D., Sol, H., Sottile, G., Sowiński, M., Spanier, F., Spiga, D., Spyrou, S., Stamatescu, V., Stamerra, A., Starling, R., Stawarz, Ł., Steenkamp, R., Stegmann, C., Steiner, S., Stergioulas, N., Sternberger, R., Sterzel, M., Stinzing, F., Stodulski, M., Straumann, U., Strazzeri, E., Stringhetti, L., Suarez, A., Suchenek, M., Sugawara, R., Sulanke, K.-H., Sun, S., Supanitsky, A.D., Suric, T., Sutcliffe, P., Sykes, J., Szanecki, M., Szepieniec, T., Szostek, A., Tagliaferri, G., Tajima, H., Takahashi, H., Takahashi, K., Takalo, L., Takami, H., Talbot, G., Tammi, J., Tanaka, M., Tanaka, S., Tasan, J., Tavani, M., Tavernet, J.-P., Tejedor, L.A., Telezhinsky, I., Temnikov, P., Tenzer, C., Terada, Y., Terrier, R., Teshima, M., Testa, V., Tezier, D., Thuermann, D., Tibaldo, L., Tibolla, O., Tiengo, A., Tluczykont, M., Todero Peixoto, C.J., Tokanai, F., Tokarz, M., Toma, K., Torii, K., Tornikoski, M., Torres, D.F., Torres, M., Tosti, G., Totani, T., Toussenel, F., Tovmassian, G., Travnicek, P., Trifoglio, M., Troyano, I., Tsinganos, K., Ueno, H., Umehara, K., Upadhya, S.S., Usher, T., Uslenghi, M., Valdes-Galicia, J.F., Vallania, P., Vallejo, G., van Driel, W., van Eldik, C., Vandenbrouke, J., Vanderwalt, J., Vankov, H., Vasileiadis, G., Vassiliev, V., Veberic, D., Vegas, I., Vercellone, S., Vergani, S., Veyssiére, C., Vialle, J.P., Viana, A., Videla, M., Vincent, P., Vincent, S., Vink, J., Vlahakis, N., Vlahos, L., Vogler, P., Vollhardt, A., von Gunten, H.-P., Vorobiov, S., Vuerli, C., Waegebaert, V., Wagner, R., Wagner, R.G., Wagner, S., Wakely, S.P., Walter, R., Walther, T., Warda, K., Warwick, R., Wawer, P., Wawrzaszek, R., Webb, N., Wegner, P., Weinstein, A., Weitzel, Q., Welsing, R., Werner, M., Wetteskind, H., White, R., Wierzcholska, A., Wiesand, S., Wilkinson, M., Williams, D.A., Willingale, R., Winiarski, K., Wischnewski, R., Wiśniewski, Ł., Wood, M., Wörnlein, A., Xiong, Q., Yadav, K.K., Yamamoto, H., Yamamoto, T., Yamazaki, R., Yanagita, S., Yebras, J.M., Yelos, D., Yoshida, A., Yoshida, T., Yoshikoshi, T., Zabalza, V., Zacharias, M., Zajczyk, A., Zanin, R., Zdziarski, A., Zech, A., Zhao, A., Zhou, X., Ziętara, K., Ziolkowski, J., Ziółkowski, P., Zitelli, V., Zurbach, C., and Żychowski, P.

Published
2013
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217. [Italian Society of Interventional Cardiology (SICI-GISE) Position paper: Transcatheter left atrial appendage occlusion in patients with non-valvular atrial fibrillation]

Author

Berti, S., Tondo, C., Basso, C., Gaspardone, A., Golino, P., Meucci, F., Montorfano, M., Parodi, G., Russo, F., Saia, F., Cardaioli, F., Santoro, G., Rapacciuolo, A., Tondo, A., Esposito, G., and Tarantini, G.

Subjects
Stroke, Thromboembolism, Atrial Fibrillation, Cardiology, Humans, Atrial fibrillation, Left atrial appendage occlusion, Atrial Appendage
Abstract

Atrial fibrillation (AF) is the most common arrhythmia worldwide. Thromboembolism from the left atrial appendage (LAA) is the most feared complication in patients with AF. The cornerstone for the management of AF is oral anticoagulation to reduce the incidence of cardioembolic stroke. There is, however, a significant proportion of patients who cannot undergo long-term oral anticoagulation. Transcatheter LAA occlusion is an evolving technology with proven benefits in terms of AF-related stroke prevention, representing a valid alternative to anticoagulation for high-risk patients with contraindications for long-term oral anticoagulation. This has resulted in the development of a plethora of transcatheter devices to achieve endocardial occlusion or epicardial exclusion of the LAA.A panel of expert Italian cardiologists gathered under the aegis of the Italian Society of Interventional Cardiology (SICI-GISE) with the aim of reviewing the most relevant aspects of LAA occlusion, underlying anatomy and pathophysiology, summarizing current clinical knowledge, and discussing the practicalities of available devices and imaging techniques. Finally, the position paper highlights the importance of an adequate environment and of an appropriate organization in order to optimize all steps of the procedure.

Published
2022

218. Children with special health care needs attending emergency department in Italy: analysis of 3479 cases

Author

Cianci, P., D'Apolito, V., Moretti, A., Barbagallo, M., Paci, S., Carbone, M. T., Lubrano, R., Urbino, A., Dionisi Vici, C., Memo, L., Zampino, G., La Marca, G., Villani, A., Corsello, G., Selicorni, A., Campania, A., Geremia, C., Castagno, E., Masi, S., Poggi, G., Vestri, M., Fossali, E., Rocchi, A., Dadalt, L., Arrighini, A., Chiappa, S., Renna, S., Piccotti, E., Borgna, C., Govoni, M. R., Biondi, A., Fossati, C., Iughetti, L., Bertolani, P., Salvatoni, A., Agosti, M., Fuca, F., Ilardi, A., Giuffrida, S., Diguardo, V., Boni, S., D'Antiga, L., Ruggeri, M., Chiaretti, A., Amarri, S., Peduto, A., Bernardi, F., Corsini, I., Deangelis, G. L., Ruberto, C., Zuccotti, G. V., Stringhi, C., Lombardi, G., Salladini, C., Dimichele, S., Parola, L., Porta, A., Biasucci, G., Bellini, M., Ortisi, M. T., Apuril, E., Midulla, F., Tarani, L., Parlapiano, G., Lietti, D., Sforzini, C., Marseglia, G. L., Savasta, S., Falsaperla, R., Vitaliti, M. C., Chiarelli, F., Rossi, N., Banderali, G., Giacchero, R., Bernardo, L., Pinto, F., Fabiani, E., Ficcadenti, A., Pellegrini, G., Giacoma, S., Biban, P., Spada, S., Tipo, V., Ghitti, C., Bolognini, S., Mariani, G., Russo, A., Colella, M. G., Verrico, A., Bruni, P., Poddighe, D., Cagnoli, G., Morandi, F., Gadaleta, A., Barbi, E., Bruno, I. I., Graziano, R., Sgaramella, P., Catalani, M. P., Baldoni, I., Colarusso, G., Galvagno, G., Barone, A. P., Longo, A., Nardella, G., Portale, G., Garigali, G., Bona, G., Erbela, M., Agostiniani, R., Nanni, L., Schieven, E., Dona, M., Varisco, T., Russo, F., Distefano, V. A., Dipietro, F., Tarallo, L., Imperato, L., Parisi, G., Salzano, R., Raiola, G., Talarico, V., Bellu, R., Cannone, A., Ferrante, P., Cianci, P, D'Apolito, V, Moretti, A, Barbagallo, M, Paci, S, Carbone, M, Lubrano, R, Urbino, A, Dionisi Vici, C, Memo, L, Zampino, G, La Marca, G, Villani, A, Corsello, G, Selicorni, A, Campania, A, Geremia, C, Castagno, E, Masi, S, Poggi, G, Vestri, M, Fossali, E, Rocchi, A, Dadalt, L, Arrighini, A, Chiappa, S, Renna, S, Piccotti, E, Borgna, C, Govoni, M, Biondi, A, Fossati, C, Iughetti, L, Bertolani, P, Salvatoni, A, Agosti, M, Fuca, F, Ilardi, A, Giuffrida, S, Diguardo, V, Boni, S, D'Antiga, L, Ruggeri, M, Chiaretti, A, Amarri, S, Peduto, A, Bernardi, F, Corsini, I, Deangelis, G, Ruberto, C, Zuccotti, G, Stringhi, C, Lombardi, G, Salladini, C, Dimichele, S, Parola, L, Porta, A, Biasucci, G, Bellini, M, Ortisi, M, Apuril, E, Midulla, F, Tarani, L, Parlapiano, G, Lietti, D, Sforzini, C, Marseglia, G, Savasta, S, Falsaperla, R, Vitaliti, M, Chiarelli, F, Rossi, N, Banderali, G, Giacchero, R, Bernardo, L, Pinto, F, Fabiani, E, Ficcadenti, A, Pellegrini, G, Giacoma, S, Biban, P, Spada, S, Tipo, V, Ghitti, C, Bolognini, S, Mariani, G, Russo, A, Colella, M, Verrico, A, Bruni, P, Poddighe, D, Cagnoli, G, Morandi, F, Gadaleta, A, Barbi, E, Bruno, I, Graziano, R, Sgaramella, P, Catalani, M, Baldoni, I, Colarusso, G, Galvagno, G, Barone, A, Longo, A, Nardella, G, Portale, G, Garigali, G, Bona, G, Erbela, M, Agostiniani, R, Nanni, L, Schieven, E, Dona, M, Varisco, T, Russo, F, Distefano, V, Dipietro, F, Tarallo, L, Imperato, L, Parisi, G, Salzano, R, Raiola, G, Talarico, V, Bellu, R, Cannone, A, Ferrante, P, Paola Cianci, Valeria D'Apolito, Alex Moretti, Massimo Barbagallo, Sabrina Paci, Maria Teresa Carbone, Riccardo Lubrano, Antonio Urbino, Carlo Dionisi Vici, Luigi Memo, Giuseppe Zampino, Giancarlo La Marca, Alberto Villani, Giovanni Corsello, Angelo Selicorni, Cianci, P., D'Apolito, V., Moretti, A., Barbagallo, M., Paci, S., Carbone, M. T., Lubrano, R., Urbino, A., Dionisi Vici, C., Memo, L., Zampino, G., La Marca, G., Villani, A., Corsello, G., Selicorni, A., Campania, A., Geremia, C., Castagno, E., Masi, S., Poggi, G., Vestri, M., Fossali, E., Rocchi, A., Dadalt, L., Arrighini, A., Chiappa, S., Renna, S., Piccotti, E., Borgna, C., Govoni, M. R., Biondi, A., Fossati, C., Iughetti, L., Bertolani, P., Salvatoni, A., Agosti, M., Fuca, F., Ilardi, A., Giuffrida, S., Diguardo, V., Boni, S., D'Antiga, L., Ruggeri, M., Chiaretti, A., Amarri, S., Peduto, A., Bernardi, F., Corsini, I., Deangelis, G. L., Ruberto, C., Zuccotti, G. V., Stringhi, C., Lombardi, G., Salladini, C., Dimichele, S., Parola, L., Porta, A., Biasucci, G., Bellini, M., Ortisi, M. T., Apuril, E., Midulla, F., Tarani, L., Parlapiano, G., Lietti, D., Sforzini, C., Marseglia, G. L., Savasta, S., Falsaperla, R., Vitaliti, M. C., Chiarelli, F., Rossi, N., Banderali, G., Giacchero, R., Bernardo, L., Pinto, F., Fabiani, E., Ficcadenti, A., Pellegrini, G., Giacoma, S., Biban, P., Spada, S., Tipo, V., Ghitti, C., Bolognini, S., Mariani, G., Russo, A., Colella, M. G., Verrico, A., Bruni, P., Poddighe, D., Cagnoli, G., Morandi, F., Gadaleta, A., Barbi, E., Bruno, I. I., Graziano, R., Sgaramella, P., Catalani, M. P., Baldoni, I., Colarusso, G., Galvagno, G., Barone, A. P., Longo, A., Nardella, G., Portale, G., Garigali, G., Bona, G., Erbela, M., Agostiniani, R., Nanni, L., Schieven, E., Dona, M., Varisco, T., Russo, F., Distefano, V. A., Dipietro, F., Tarallo, L., Imperato, L., Parisi, G., Salzano, R., Raiola, G., Talarico, V., Bellu, R., Cannone, A., and Ferrante, P.

Subjects
Male, Metabolic disease, Hospitalization rate, Congenital skeletal condition, Children with special health care needs, Emergency department, Isolated CNS malformation, Metabolic diseases, Multiple AED therapy, Neuromuscular diseases, Syndromic disorders, True isolated microcephaly, 0302 clinical medicine, Clinical history, Medicine, Child, education.field_of_study, Neuromuscular disease, Settore MED/38, Disabled Children, Hospitalization, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Italy, Child, Preschool, Female, Children with special health care need, Emergency Service, Hospital, medicine.medical_specialty, Adolescent, Population, Triage Code, 03 medical and health sciences, Pharmacotherapy, 030225 pediatrics, Humans, Medical prescription, education, Retrospective Studies, Health Services Needs and Demand, Syndromic disorder, business.industry, Research, Infant, Newborn, Infant, 030208 emergency & critical care medicine, Children with special health care needs, Congenital skeletal conditions,Emergency department, Hospitalization rate, Isolated CNS malformation, Metabolic diseases, Multiple AED therapy, Neuromuscular diseases, Syndromic disorders, True isolated microcephaly, Family medicine, Chronic Disease, business, Facilities and Services Utilization
Abstract

Background Although children with special health care needs (CSHCN) represent a minority of the population, they go through more hospitalizations, more admissions to the Emergency Department (ED), and receive a major number of medical prescriptions, in comparison to general pediatric population. Objectives of the study were to determine the reasons for admission to the ED in Italian CSHCN, and to describe the association between patient’s demographic data, clinical history, and health services requirements. Methods Ad hoc web site was created to collect retrospective data of 3479 visits of CSHCN to the ED in 58 Italian Hospitals. Results Seventy-two percent of patients admitted to ED were affected by a previously defined medical condition. Most of the ED admissions were children with syndromic conditions (54%). 44.2% of the ED admissions were registered during the night-time and/or at the weekends. The hospitalization rate was of 45.6% among patients admitted to the ED. The most common reason for admission to the ED was the presence of respiratory symptoms (26.6%), followed by gastrointestinal problems (21.3%) and neurological disorders (18.2%). 51.4% of the access were classified as ‘urgent’, with a red/yellow triage code. Considering the type of ED, 61.9% of the visits were conducted at the Pediatric EDs (PedEDs), 33.5% at the Functional EDs (FunEDs) and 4.6% at the Dedicated EDs (DedEDs). Patients with more complex clinical presentation were more likely to be evaluated at the PedEDs. CSHCN underwent to a higher number of medical procedures at the PedEDs, more in comparison to other EDs. Children with medical devices were directed to a PedED quite exclusively when in need for medical attention. Subjects under multiple anti-epileptic drug therapy attended to PedEDs or FunEDs generally. Patients affected by metabolic diseases were more likely to look for medical attention at FunEDs. Syndromic patients mostly required medical attention at the DedEDs. Conclusions Access of CSHCN to an ED is not infrequent. For this reason, it is fundamental for pediatricians working in any kind of ED to increase their general knowledge about CHSCN and to gain expertise in the management of such patients and their related medical complexity.

Published
2020

219. Liver stiffness measurement by vibration-controlled transient elastography improves outcome prediction in primary biliary cholangitis

Author

Corpechot, C, Carrat, F, Gaouar, F, Chau, F, Hirschfield, G, Gulamhusein, A, Montano-Loza, A, Lytvyak, E, Schramm, C, Pares, A, Olivas, I, Eaton, J, Osman, K, Dalekos, G, Gatselis, N, Nevens, F, Cazzagon, N, Zago, A, Russo, F, Abbas, N, Trivedi, P, Thorburn, D, Saffioti, F, Barkai, L, Roccarina, D, Calvaruso, V, Fichera, A, Delamarre, A, Medina-Morales, E, Bonder, A, Patwardhan, V, Rigamonti, C, Carbone, M, Invernizzi, P, Cristoferi, L, van der Meer, A, de Veer, R, Zigmond, E, Yehezkel, E, Kremer, A, Deibel, A, Dumortier, J, Bruns, T, Große, K, Pageaux, G, Wetten, A, Dyson, J, Jones, D, Chazouillères, O, Hansen, B, de Lédinghen, V, Corpechot, Christophe, Carrat, Fabrice, Gaouar, Farid, Chau, Frederic, Hirschfield, Gideon, Gulamhusein, Aliya, Montano-Loza, Aldo J, Lytvyak, Ellina, Schramm, Christoph, Pares, Albert, Olivas, Ignasi, Eaton, John E, Osman, Karim T, Dalekos, George, Gatselis, Nikolaos, Nevens, Frederik, Cazzagon, Nora, Zago, Alessandra, Russo, Francesco Paolo, Abbas, Nadir, Trivedi, Palak, Thorburn, Douglas, Saffioti, Francesca, Barkai, Laszlo, Roccarina, Davide, Calvaruso, Vicenza, Fichera, Anna, Delamarre, Adèle, Medina-Morales, Esli, Bonder, Alan, Patwardhan, Vilas, Rigamonti, Cristina, Carbone, Marco, Invernizzi, Pietro, Cristoferi, Laura, van der Meer, Adriaan, de Veer, Rozanne, Zigmond, Ehud, Yehezkel, Eyal, Kremer, Andreas E, Deibel, Ansgar, Dumortier, Jérôme, Bruns, Tony, Große, Karsten, Pageaux, Georges-Philippe, Wetten, Aaron, Dyson, Jessica, Jones, David, Chazouillères, Olivier, Hansen, Bettina, de Lédinghen, Victor, Corpechot, C, Carrat, F, Gaouar, F, Chau, F, Hirschfield, G, Gulamhusein, A, Montano-Loza, A, Lytvyak, E, Schramm, C, Pares, A, Olivas, I, Eaton, J, Osman, K, Dalekos, G, Gatselis, N, Nevens, F, Cazzagon, N, Zago, A, Russo, F, Abbas, N, Trivedi, P, Thorburn, D, Saffioti, F, Barkai, L, Roccarina, D, Calvaruso, V, Fichera, A, Delamarre, A, Medina-Morales, E, Bonder, A, Patwardhan, V, Rigamonti, C, Carbone, M, Invernizzi, P, Cristoferi, L, van der Meer, A, de Veer, R, Zigmond, E, Yehezkel, E, Kremer, A, Deibel, A, Dumortier, J, Bruns, T, Große, K, Pageaux, G, Wetten, A, Dyson, J, Jones, D, Chazouillères, O, Hansen, B, de Lédinghen, V, Corpechot, Christophe, Carrat, Fabrice, Gaouar, Farid, Chau, Frederic, Hirschfield, Gideon, Gulamhusein, Aliya, Montano-Loza, Aldo J, Lytvyak, Ellina, Schramm, Christoph, Pares, Albert, Olivas, Ignasi, Eaton, John E, Osman, Karim T, Dalekos, George, Gatselis, Nikolaos, Nevens, Frederik, Cazzagon, Nora, Zago, Alessandra, Russo, Francesco Paolo, Abbas, Nadir, Trivedi, Palak, Thorburn, Douglas, Saffioti, Francesca, Barkai, Laszlo, Roccarina, Davide, Calvaruso, Vicenza, Fichera, Anna, Delamarre, Adèle, Medina-Morales, Esli, Bonder, Alan, Patwardhan, Vilas, Rigamonti, Cristina, Carbone, Marco, Invernizzi, Pietro, Cristoferi, Laura, van der Meer, Adriaan, de Veer, Rozanne, Zigmond, Ehud, Yehezkel, Eyal, Kremer, Andreas E, Deibel, Ansgar, Dumortier, Jérôme, Bruns, Tony, Große, Karsten, Pageaux, Georges-Philippe, Wetten, Aaron, Dyson, Jessica, Jones, David, Chazouillères, Olivier, Hansen, Bettina, and de Lédinghen, Victor

Abstract

Background & Aims: Liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE) has been shown to predict outcomes of patients with primary biliary cholangitis (PBC) in small-size studies. We aimed to validate the prognostic value of LSM in a large cohort study. Methods: We performed an international, multicentre, retrospective follow-up study of 3,985 patients with PBC seen at 23 centres in 12 countries. Eligibility criteria included at least 1 reliable LSM by VCTE and a follow-up ≥ 1 year. Independent derivation (n = 2,740) and validation (n = 568) cohorts were built. The primary endpoint was time to poor clinical outcomes defined as liver-related complications, liver transplantation, or death. Hazard ratios (HRs) with CIs were determined using a time-dependent multivariable Cox regression analysis. Results: LSM was independently associated with poor clinical outcomes in the derivation (5,324 LSMs, mean follow-up 5.0 ± 3.1 years) and validation (1,470 LSMs, mean follow-up 5.0 ± 2.8 years) cohorts: adjusted HRs (95% CI) per additional kPa were 1.040 (1.026–1.054) and 1.042 (1.029–1.056), respectively (p <0.0001 for both). Adjusted C-statistics (95% CI) at baseline were 0.83 (0.79–0.87) and 0.92 (0.89–0.95), respectively. Between 5 and 30 kPa, the log-HR increased as a monotonic function of LSM. The predictive value of LSM was stable in time. LSM improved the prognostic ability of biochemical response criteria, fibrosis scores, and prognostic scores. The 8 kPa and 15 kPa cut-offs optimally separated low-, medium-, and high-risk groups. Forty percent of patients were at medium to high risk according to LSM. Conclusions: LSM by VCTE is a major, independent, validated predictor of PBC outcome. Its value as a surrogate endpoint for clinical benefit in PBC should be considered. Lay summary: Primary biliary cholangitis (PBC) is a chronic autoimmune disease, wherein the body's immune system mistakenly attacks the bile ducts. PBC progresses

Published
2022

220. Moderate-to-severe atopic dermatitis in adolescents treated with dupilumab: A multicentre Italian real-world experience

Author

Stingeni, L, Bianchi, L, Antonelli, E, Caroppo, E S, Ferrucci, S M, Ortoncelli, M, Fabbrocini, G, Nettis, E, Schena, D, Napolitano, M, Gola, M, Bonzano, L, Rossi, M, Belloni Fortina, A, Balato, A, Peris, Ketty, Foti, C, Guarneri, F, Romanelli, M, Patruno, C, Savoia, P, Fargnoli, M C, Russo, F, Errichetti, E, Bianchelli, T, Pellacani, G, Feliciani, C, Offidani, A, Corazza, M, Micali, G, Milanesi, N, Malara, G, Chiricozzi, Andrea, Tramontana, M, Hansel, K, Peris, K (ORCID:0000-0002-5237-0463), Chiricozzi, A (ORCID:0000-0002-6739-0387), Stingeni, L, Bianchi, L, Antonelli, E, Caroppo, E S, Ferrucci, S M, Ortoncelli, M, Fabbrocini, G, Nettis, E, Schena, D, Napolitano, M, Gola, M, Bonzano, L, Rossi, M, Belloni Fortina, A, Balato, A, Peris, Ketty, Foti, C, Guarneri, F, Romanelli, M, Patruno, C, Savoia, P, Fargnoli, M C, Russo, F, Errichetti, E, Bianchelli, T, Pellacani, G, Feliciani, C, Offidani, A, Corazza, M, Micali, G, Milanesi, N, Malara, G, Chiricozzi, Andrea, Tramontana, M, Hansel, K, Peris, K (ORCID:0000-0002-5237-0463), and Chiricozzi, A (ORCID:0000-0002-6739-0387)

Abstract

Background Moderate-to-severe atopic dermatitis (AD) in the adolescence is a high burden disease, and its treatment can be very challenging due to paucity of approved systemic drugs for this age and their side-effects. Dupilumab was recently approved for treatment of adolescent AD. Objectives A multicentre, prospective, real-world study on the effectiveness and safety of dupilumab in adolescents (aged from >= 12 to <18 years) with moderate-to-severe AD was conducted. The main AD clinical phenotypes were also examined. Methods Data of adolescents with moderate-to-severe AD treated with dupilumab at label dosage for 16 weeks were collected. Treatment outcome was assessed by EASI, NRS itch, NRS sleep loss and CDLQI scores at baseline and after 16 weeks of treatment. The clinical scores were also evaluated according to clinical phenotypes. Results One hundred and thirty-nine adolescents were enrolled in the study. Flexural eczema and head and neck eczema were the most frequent clinical phenotypes, followed by hand eczema and portrait-like dermatitis. Coexistence of more than 1 phenotype was documented in 126/139 (88.5%) adolescents. Three patients (2.1%) contracted asymptomatic SARS-CoV-2 infection and 1 of the discontinued dupilumab treatment before the target treatment period. A significant improvement in EASI, NRS itch, NRS sleep loss and CDLQI was observed after 16 weeks of treatment with dupilumab. This outcome was better than that observed in clinical trials. Dupilumab resulted effective in all AD phenotypes, especially in diffuse eczema. Twenty-eight (20.1%) patients reported adverse events, conjunctivitis and flushing being the most frequent. None of patients discontinued dupilumab due to adverse event. Conclusions Dupilumab in adolescent AD showed excellent effectiveness at week 16 with consistent improvement of all clinical scores. Moreover, dupilumab showed a good safety profile also in this COVID-19 pandemic era.

Published
2022

221. Evaluation of air quality forecasting system FORAIR-IT over Europe and Italy at high resolution for year 2017

Author

Adani, M, D'Isidoro, M, Mircea, M, Guarnieri, G, Vitali, L, D'Elia, I, Ciancarella, L, Gualtieri, M, Briganti, G, Cappelletti, A, Piersanti, A, Stracquadanio, M, Righini, G, Russo, F, Cremona, G, Villani, M, Zanini, G, Adani, M, D'Isidoro, M, Mircea, M, Guarnieri, G, Vitali, L, D'Elia, I, Ciancarella, L, Gualtieri, M, Briganti, G, Cappelletti, A, Piersanti, A, Stracquadanio, M, Righini, G, Russo, F, Cremona, G, Villani, M, and Zanini, G

Abstract

Air pollution represents a global threat leading to large impacts on health and ecosystems and many European areas still show a poor air quality. Air quality forecasts are instruments, which may support authorities and citizens in reducing these impacts. This work presents the development and the performance evaluation of an air quality forecast system for Italy: FORAIR- IT. It operates at both European and Italian scales at 20 km and 4 km resolution, respectively. The forecasts' performances are evaluated against measurements, through a comparison with CAMS_50 validated reanalysis ensemble and by an in depth evaluation during a long lasting PM10 episode, which occurred in Emilia Romagna region in October 2017. The results show similar skill scores between FORAIT-IT and CAMS_50 for PM10, PM2.5, NO2 and O-3 concentrations. The increase of model resolution over Italy and the use of the national emission inventory lead to a better reproduction of pollutant concentrations at urban and suburban sites for PM10, PM(2.5 )and NO2. The analysis of the pollution episode shows that the correct forecast of the meteorological forcing is fundamental in capturing both the timing and the occurrence of the exceedances, while the poor performance of the model in reproducing the magnitude of the exceedances may be due to the lack of information on some emissions sources such as agricultural biomass burning.

Published
2022

222. Long‐term outcomes of direct acting antivirals in post‐transplant advanced hepatitis C virus recurrence and fibrosing cholestatic hepatitis

Author

Vukotic, R., Conti, F., Fagiuoli, S., Morelli, M. C., Pasulo, L., Colpani, M., Foschi, F. G., Berardi, S., Pianta, P., Mangano, M., Donato, M. F., Malinverno, F., Monico, S., Tamè, M., Mazzella, G., Belli, L. S., Viganò, R., Carrai, P., Burra, P., Russo, F. P., Lenci, I., Toniutto, P., Merli, M., Loiacono, L., Iemmolo, R., Degli Antoni, A. M., Romano, A., Picciotto, A., Rendina, M., and Andreone, P.

Published
2017
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223. Responding to a school SARS-CoV-2 outbreak: Insights and policy implications emerging from the pandemic.

Author

Marrero, M. C., Petraccone, J. Bonfini, Guida, S., Montesi, A., Fanti, A., Gigliola, G., Scalingi, S., Aucone, R., Russo, F. T., Lovetro, D., Facente, F., Germini, F., Del Prete, J., Ierardi, T., Zagaria, N., Gerbasi, G., Brandimarte, M. A., Parente, P., Di Rosa, E., and Paglione, L.

Subjects
SARS-CoV-2, SCHOOL environment, CONTACT tracing, COVID-19 pandemic, QUARANTINE, HEALTH promotion
Abstract

Copyright of Annali di Igiene, Medicina Preventiva e di Comunità is the property of Societa Editrice Universo s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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233. The AISHa ion source at INFN-LNS

Author

Castro, G., primary, Celona, L., additional, Chines, F., additional, Costanzo, G., additional, Gammino, S., additional, Leonardi, O., additional, Malferrari, L., additional, Massara, A., additional, Maugeri, C., additional, Neri, L., additional, Odorici, F., additional, Passarello, S., additional, Reitano, R., additional, Russo, F., additional, and Siliato, D., additional

Published
2022
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235. Contributors

Author

Abdolghaffari, Amir Hossein, primary, Abdollahi, Mohammad, additional, Ahanchian, Hamid, additional, Ahmad, Farah N., additional, Akbarzadeh, Fariborz, additional, Alighieri, Giovanni, additional, Amini, Amir, additional, Anadón, Arturo, additional, Anania, Caterina, additional, Annibale, Bruno, additional, Arena, Mattia Pia, additional, Arena, Angela, additional, Arés, Irma, additional, Argyri, Anthoula A., additional, Aslim, Belma, additional, Aydaş, Selcen Babaoğlu, additional, Azimi, Amirreza, additional, Ballesteros, Antonio O., additional, Barbosa, Joana, additional, Bastani, Parvin, additional, Bedani, Raquel, additional, Betta, Pasqua, additional, Biglu, Mohammad-Hossein, additional, Borges, Sandra, additional, Bucci, C., additional, Buriti, Flávia C.A., additional, Camacho-Ruiz, R.M., additional, Capozzi, Vittorio, additional, Catenazzi, Piero, additional, Celani, Camilla, additional, Chaluvadi, Saikiran, additional, Champagne, Claude P., additional, Chiesa, Claudio, additional, Clark, Eva H., additional, Collier, Robert J., additional, Colombo, Jacopo, additional, de Moreno de LeBlanc, Alejandra, additional, de Morais, Elisa Carvalho, additional, Dekker, M., additional, Di Venere, D., additional, Drago, Lorenzo, additional, Farnworth, Edward R., additional, Feleszko, Wojciech, additional, Fernandez-Arrojo, Lucia, additional, Fernández-López, J., additional, Finamore, Alberto, additional, Fiocco, Daniela, additional, Gatesoupe, F.J., additional, Ghasemi-Niri, Farnaz, additional, Giacchi, Valentina, additional, Golkhalkhali, Babak, additional, Gomez-Zavaglia, A., additional, Gooshe, Maziar, additional, Gundogdu, Zuhal, additional, Hanning, Irene, additional, Hashemi, Seyed Mohammad Bagher, additional, Hemalatha, Rajkumar, additional, Homayouni, Aziz, additional, Hotchkiss, Arland T., additional, Iovino, P., additional, Saad, Susana Marta Isay, additional, Jafarabadi, Mohammad Asghari, additional, Jafari, Seyed Ali, additional, Jamaluddin, Rosita, additional, Jeong, Ji-Kang, additional, Jirillo, Felicita, additional, Jirillo, Emilio, additional, Jones, Rheinallt M., additional, Kaur, Baljinder, additional, Kaur, Gaganjot, additional, Keshtiban, Ata K., additional, Khalili, Mohammad, additional, Khalili, Leyla, additional, Khalili, Leila, additional, Kirmiz, Nina, additional, Kumar, Manoj, additional, Lahner, Edith, additional, Lavermicocca, P., additional, LeBlanc, Jean Guy, additional, Likotrafiti, Eleni, additional, Lim, Ying-Jye, additional, Lingbeck, Jody, additional, López, Paloma, additional, Mohedano, Mª Luz, additional, Magrone, Thea, additional, Mahdavi, Reza, additional, Maleki, Davood, additional, Mallah, Fatemeh, additional, Marathe, Shreesh J., additional, Marotta, Francesco, additional, Martínez, María Aránzazu, additional, Martinez-Augustin, O., additional, Martínez-Larrañaga, María Rosa, additional, Mehrabany, Elnaz Vaghef, additional, Mills, David A., additional, Stover, Mitchel Graham, additional, Mobili, P., additional, Mohammad, Diya, additional, Mohammad-Alizadeh-Charandabi, Sakineh, additional, Redzwan, S. Mohd, additional, Monedero, Vicente, additional, Moreno Villares, Jose M., additional, Moreno-Vilet, L., additional, Morrow, Lee E., additional, Motoori, Masaaki, additional, Murthy, Jayasimha N., additional, Nácher-Vázquez, Montserrat, additional, Nagpal, Ravinder, additional, Nielsen, Dennis Sandris, additional, Nikniaz, Hossein, additional, Nikniaz, Leila, additional, Nikniaz, Zeinab, additional, Notararigo, Sara, additional, Nunes, Vânia dos Santos, additional, Orel, Rok, additional, Osman, Ali, additional, Ouwehand, Arthur C., additional, Pacifico, Lucia, additional, Panagou, Efstathios Z., additional, Park, Kun-Young, additional, Payahoo, Laleh, additional, Peluso, Ilaria, additional, Pérez-Alvarez, J.A., additional, Pérez-Ramos, Adrian, additional, Plou, Francisco J., additional, Poorbaghi, Seyedeh Leila, additional, Portales-Pérez, D.P., additional, Quigley, Eamonn M.M., additional, Ranjbar, Fatemeh, additional, Reberšak, Lea Vodušek, additional, Rhoades, Jonathan, additional, Ricke, Steven C., additional, Rodriguez-Colinas, Barbara, additional, Rodríguez-Díaz, Jesús, additional, Romano, N., additional, Russo, Pasquale, additional, Russo, F., additional, Ruszczyński, Marek, additional, Saad, Susana M.I., additional, de Medina, F. Sánchez, additional, Santonicola, A., additional, Sayas-Barberá, M.E., additional, Sciacca, Pietro, additional, Scorrano, Antonio, additional, Sendra, E., additional, Sepehrimanesh, Masood, additional, Serafini, Mauro, additional, Shek, Lynette Pei-Chi, additional, Shokrvash, Behjat, additional, Sisto, A., additional, Sivieri, Katia, additional, Skalkam, Maria Lena, additional, Soh, Shu-E, additional, Spano, Giuseppe, additional, Sugimura, Keijiro, additional, Tanaka, Koji, additional, Tassou, Chrysoula C., additional, Teixeira, Paula, additional, Tennilä, Julia, additional, Toscano, Marco, additional, Tripathi, Alok S., additional, Tymczyszyn, E., additional, Valerio, F., additional, van Zanten, Gabriella, additional, Villas Boas, Paulo José Fortes, additional, Wachholz, Patrick Alexander, additional, Watson, Ronald Ross, additional, Wiese, Maria, additional, Yadav, Hariom, additional, Yam, Kit L., additional, Yano, Masahiko, additional, Zeng, Hongliang, additional, Zhang, Yi, additional, Zheng, Baodong, additional, Ziyadi, Somayeh, additional, and Zuppa, Antonio Alberto, additional

Published
2016
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236. ST-Elevation Myocardial Infarction in Patients With COVID-19

Author

Stefanini, G. G., Montorfano, M., Trabattoni, D., Andreini, D., Ferrante, G., Ancona, M., Metra, M., Curello, S., Maffeo, D., Pero, G., Cacucci, M., Assanelli, E., Bellini, B., Russo, F., Ielasi, A., Tespili, M., Danzi, G. B., Vandoni, P., Bollati, M., Barbieri, L., Oreglia, J., Lettieri, C., Cremonesi, A., Carugo, S., Reimers, B., Condorelli, G., and Chieffo, A.

Subjects
Male, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Pneumonia, Viral, coronavirus, Coronary Angiography, medicine.disease_cause, Betacoronavirus, Risk Factors, St elevation myocardial infarction, Physiology (medical), Internal medicine, Correspondence, Pandemic, Research Letter, 80 and over, Humans, Medicine, In patient, Viral, Pandemics, Aged, Coronavirus, Aged, 80 and over, biology, SARS-CoV-2, business.industry, COVID-19, Pneumonia, Middle Aged, biology.organism_classification, ST elevation myocardial infarction, Echocardiography, Cardiology, Female, Coronavirus Infections, ST Elevation Myocardial Infarction, Cardiology and Cardiovascular Medicine, business
Published
2020

237. Pulmonary hypertension in congenital diaphragmatic hernia: ANTENATAL PREDICTION AND IMPACT ON NEONATAL MORTALITY

Author

Basurto D, Maria Russo F, Papastefanou I, Bredaki E, Allegaert K, Pertierra-Cortada A, Debeer A, Catte L, Lewi L, Devlieger R, Coppi P, Gratacós E, Gómez-Domínguez O, and Deprest J

Abstract

OBJECTIVE: To determine the prevalence of pulmonary hypertension(PAH) in left-sided congenital diaphragmatic hernia(CDH); how we could predict it; and how PAH contributed to the model for mortality prediction.; STUDY DESIGN: Retrospective analysis in three European centers. The primary outcome was the presence of PAH on postnatal day(d)1,7, and at discharge. Studied predictors of PAH were: observed/expected-lung/head-ratio(o/e LHR), liver-herniation, FETO, and gestational age(GA) at delivery. The combined effect of pre-and postnatal variables on mortality was modeled by Cox regression.; RESULTS: Of the 197 neonates, 56(28.4%) died. At d1, 67.5%(133/197) had PAH and 61.9% (101/163) by d7. Overall, 6.4% (9/141) had PAH at discharge.At d1, o/eLHR(OR 0.96) and FETO(OR 2.99) independently correlated to PAH(AUC:0.74). At d7, PAH significantly correlated only with the use of FETO (OR 3.9;AUC:0.65). None were significant for PAH at discharge.Combining the occurrence of PAH with antenatal biomarkers improved mortality prediction(p=0.02), in a model including o/eLHR(HR:0.94), FETO(HR:0.35), liver herniation(HR:16.78), and PAH(HR:15.95).; CONCLUSIONS: Antenatal prediction of PAH was only moderate. The postnatal occurrence of PAH further increases the risk of death. Whereas this may be used to counsel parents in the postnatal period, our study demonstrates there is a need to find more accurate antenatal predictors for PAH. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Published
2022

238. Digestive diseases. 2022-2025 edition

Author

Abenavoli Monteblanco, L., Aghemo, A. M., Alvaro, D., Annibale, B., Arcidiacono, P. G., Ardizzone, S., Armuzzi, A., Azzaroli, F., Badiali, D., Baiocchi, L., Baldoni, M., Barone, M., Bassotti, G., Bellini, M., Benedetti, A., Bertino, G., Biagi, F., Biancone, L., Brilanti, S., Bugianesi, E., Burra, P., Calabrese, E., Calvaruso, V., Cammarata, G., Caprioli, F. A., Carbone, M., Cardinale, V., Castiglione, F., Catanzaro, R., Cavestro, G. M., Cazzagon, N., Ciancio, A., Consolo, P., Corleto, V. D., Crocè, S. L., Cuomo, R., de Bortoli, N., Del Vecchio Blanco, G., Dell'Era, A., Di Leo, A., Di Marco, V., Dore, P. M., Eusebi, L. H. U., Fabris, L., Facciorusso, A., Fantini, M. C., Federico, A., Fries, W., Fuccio, L., Fusaroli, P., Gabrielli, A., Galli, A., Giannini, E. G., Corradini, S. G., Gravina, A. G., Grassi, L., Guarino, M. P., Invernizzi, P., Iovino, P., Lahner, E., Lampertico, P., Larussa, T., Latella, G., Luzza, F., Maconi, G. E., Marabotto, E., Marchi, S., Marzioni, M., Merli, M., Milani, S., Montagnani, M., Morelli, O., Morisco, F., Nardone, G. A. P., Pallotta, N., Papa, A., Penagini, R., Petta, S., Picarelli, A., Principi, M., Rapaccini, G. L., Pepici, A., Ricci, C., Ricciardiello, L., Ridola, L., Rispo, A., Romano, M., Rumi, M. G., Russo, F. P., Saracco, G. M., Sarnelli, G., Savarino, E. V., Severi, C., Svegliati Baroni, G., Tarocchi, M., Vecchi, M., Viscido, A., Zagari, R. M., and Zingone, F.

Subjects
colon, liver diseases, diseases of the esophagus, stomach, duodenum, liver diseases, diseases of the biliary tract , pancreas, small intestine, colon, duodenum, diseases of the biliary tract, pancreas, small intestine, diseases of the esophagus, stomach
Published
2022

239. Argument-Checking: A Critical Pedagogy Approach to Digital Literacy

Author

Brave, R., Russo, F., Wagemans, J., Ciracì, F., Miglietta, G., Gatto, C., ILLC (FGw), and ACLC (FGw)

Abstract

The digital revolution brought about unprecedented changes in people’s daily lives as well as in techno-scientific contexts. In this paper, we address the problem of information overload people experience in online media, news outlets, and social media. The problem is well-known for its negative influence on the quality of online information, with abundant discussion on the promise of fact-checking and the potential role of censorship and moderation by social media. We instead discuss the issue from the perspective of digital literacy; specifically, we advance the view that our procedure of argument-checking can enhance such literacy, as a form of critical pedagogy, thereby contributing to improving the quality of online information.

Published
2022

240. Rapid spread of a new West Nile virus lineage 1 associated with increased risk of neuroinvasive disease during a large outbreak in northern Italy, 2022: One Health analysis

Author

Barzon L, Pacenti M, Montarsi F, Fornasiero D, Gobbo F, Quaranta E, Monne I, Fusaro A, Volpe A, Sinigaglia A, Riccetti S, Molin ED, Satto S, Lisi V, Gobbi F, Galante S, Feltrin G, Valeriano V, Favero L, Russo F, Mazzucato M, Bortolami A, Mulatti P, Terregino C, Capelli G.

Published
2022
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241. Correction to: Long-term safety, discontinuation and mortality in an Italian cohort with advanced Parkinson’s disease on levodopa/carbidopa intestinal gel infusion (Journal of Neurology, (2022), 269, 10, (5606-5614), 10.1007/s00415-022-11269-7)

Author

Garri, F., Russo, F. P., Carrer, T., Weis, L., Pistonesi, F., Mainardi, M., Sandre, M., Savarino, E., Farinati, F., Del Sorbo, F., Soliveri, P., Calandrella, D., Biundo, R., Carecchio, M., Zecchinelli, A. L., Pezzoli, G., and Antonini, A.

Published
2022

242. Techno-Scientific Practices: An Informational Approach

Author

Russo, F. and ILLC (FGw)

Abstract

In scholarly debates, as well as in everyday parlance, we tend to pull science and technology apart: science gives us theory, and technology applies it. In practice, however, science and technologies are highly intertwined. In Techno-Scientific Practices: An Informational Approach, Federica Russo looks at the practice of science and elucidates the role of technologies and instruments in the process of knowledge production. In this exercise, it becomes evident that technologies cannot be analyzed on their own, but always in relation to epistemic agents. Thus, Techno-Scientific Practices emphasizes the importance of analyzing the process of knowledge production in techno-scientific contexts, in which there is a triad of relations to look at: us, the instruments, and the world. The book thus builds bridges between the philosophy of science, philosophy of technology, and science and technology studies in an unprecedent way.

Published
2022

243. Antenatal management of congenital diaphragmatic hernia: What's next ?

Author

Russo F, Benachi A, Gratacós E, Zani A, Keijzer R, Partridge E, Sananes N, De Coppi P, Aertsen M, Nicolaides KH, and Deprest J

Abstract

Congenital diaphragmatic hernia can be diagnosed in the prenatal period and its severity can be measured by fetal imaging. There is now level I evidence that, in selected cases, Fetoscopic Endoluminal Tracheal Occlusion with a balloon increases survival to discharge from the neonatal unit as well as the risk for prematurity. Both effects are dependent on the time point of tracheal occlusion. Fetoscopic Endoluminal Tracheal Occlusion may also lead to iatrogenic death when the balloon cannot be timely retrieved. The implementation of the findings from our clinical studies, may also vary based on local conditions. These may be different in terms of available skill set, access to fetal therapy, as well as outcome based on local neonatal management. We encourage prior benchmarking of local outcomes with optimal postnatal management, based on large enough numbers and using identical criteria as in the recent trials. We propose to work further on prenatal prediction methods, and the improvement of fetal intervention. In this manuscript, we describe a research agenda from a fetal medicine perspective. This research should be in parallel with innovation in neonatal and pediatric (surgical) management of this condition.

Published
2022

248. Inflammatory bowel diseases and work disability: A systematic review of predictive factors

Author

LESO V., GERVETTI P., MACRINI M. C., RUSSO F., IAVICOLI I., Leso, V., Gervetti, P., Macrini, M. C., Russo, F., and Iavicoli, I.

Subjects
Crohn's disease, Disability pension, Ulcerative coliti, Work disability, Predictive factor, Inflammatory bowel disease
Abstract

OBJECTIVE: Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and Ulcerative Colitis (UC), are chronic, relapsing intestinal disorders that may severely compromise patients' labour force participation. In this context, the present review aims to provide an overview on possible IBD pathological, socio- demographic, and treatment-related factors predictive for work disability with the purpose to provide guidance for a successful clinical and occupational management. MATERIALS AND METHODS: A systematic review of PubMed, Scopus, and ISI Web of Science databases was performed to retrieve all the studies addressing IBD-related predictors for work disability. RESULTS: Several factors have been suggested to predict work disability in the 15 revised investigations, although with not homogeneous results. Having CD was reported as a significantly better predictor for permanent work disability compared to UC, maybe in relation to the generally more serious disease course. Activity and severity of IBD, also indicated by the need for surgical treatment and comorbidities, was related to a significantly greater risk for work disability, although the exact role of other variables, i.e., specific symptoms, disease pattern and inflammatory parameters are still unclear. Among demographic factors, a significant predictive role has been suggested for female gender. CONCLUSIONS: Further research seems necessary to confirm the role of IBD related factors on work disability, and on other parameters of work impairment, i.e., absenteeism, presenteeism, activity and productivity loss. Additionally, work disability should be evaluated in relation to specific occupational risk factors. Overall, this may require a multidisciplinary approach aimed to achieve an adequate IBD clinical evaluation and management, an improvement of patients' psychosocial and professional well-being, while appropriately assessing and managing risks in the workplace.

Published
2021

250. Risk factors and action thresholds for the novel coronavirus pandemic. Insights from the Italian Society of Nephrology COVID-19 Survey

Author

Nordio, M., Reboldi, G., Di Napoli, A., Quintaliani, G., Alberici, F., Postorino, M., Aucella, F., Messa, P., Brunori, G., Bosco, M., Malberti, F., Mandreoli, M., Mazzaferro, S., Movilli, E., Ravera, M., Salomone, M., Santoro, D., Postorinolimido, M. A., Bonomini, M., Stingone, A., Maccarone, M., Di Loreto, E., Stacchiotti, L., Malandra, R., Chiarella, S., D'Agostino, F., Fuiano, G., Nicodemo, L., Bonofiglio, R., Greco, S., Mallamaci, F., Barreca, E., Caserta, C., Bruzzese, V., Galati, D., Tramontana, D., Viscione, M., Chiuchiolo, L., Tuccillo, S., Sepe, M., Vitale, F., Ciriana, E., Martignetti, V., Caserta, D., Stizzo, A., Romano, A., Iulianiello, G., Cascone, E., Minicone, P., Chiricone, D., Delgado, G., Barbato, A., Celentano, S., Molfino, I., Coppola, S., Raiola, I., Abategiovanni, M., Borrelli, S., Margherita, C., Bruno, F., Ida, M., Aliperti, E., Potito, D., Cuomo, G., De Luca, M., Merola, M., Botta, C., Garofalo, G., Alinei, P., Paglionico, C., Roano, M., Vitale, S., Ierardi, R., Fimiani, V., Conte, G., Di Natale, G., Romano, M., Di Marino, V., Scafarto, A., Meccariello, S., Pecoraro, C., Di Stazio, E., Di Meglio, E., Cuomo, A., Maresca, B., Rotaia, E., Capasso, G., Auricchio, M., Pluvio, C., Maddalena, L., De Maio, A., Palladino, G., Buono, F., Gigliotti, G., Mancini, E., La Manna, G., Storari, A., Mosconi, G., Cappelli, G., Scarpioni, R., Gregorini, M., Rigotti, A., Mancini, W., Bianco, F., Boscutti, G., Amici, G., Tosto, M., Fini, R., Pace, G., Cioffi, A., Boccia, E., Di Lullo, L., Di Zazzo, G., Simonelli, R., Bondatti, F., Miglio, L., Rifici, N., Treglia, A., Muci, M., Baldinelli, G., Rizzi, E., Lonzi, M., De Cicco, C., Forte, F., De Paolis, P., Grandaliano, Giuseppe, Cuzziol, C., Torre, V. M., Sfregola, P., Rossi, V., Fabio, G., Flammini, A., Filippini, A., Onorato, L., Vendola, F., Di Daniela, N., Alfarone, C., Scabbia, L., Ferrazzano, M., Grotta, B. D., Gamberini, M., Fazzari, L., Mene, P., Morgia, A., Catucci, A., Palumbo, R., Puliti, M., Marinelli, R., Polito, P., Marrocco, F., Morabito, S., Rocca, R., Nazzaro, L., Lavini, R., Iamundo, V., Chiappini, M., Casarci, M., Morosetti, M., Hassan, S., Firmi, G., Galliani, M., Serraiocco, M., Feriozzi, S., Valentini, W., Sacco, P., Garibotto, G., Cappelli, V., Saffioti, C., Repetto, M., Rolla, D., Lorenz, M., Pedrini, L., Polonioli, D., Galli, E., Ruggenenti, P., Scolari, F., Bove, S., Costantino, E., Bracchi, M., Mangano, S., Depetri, G., La Milia, V., Farina, M., Zecchini, S., Savino, R., Melandri, M., Guastoni, C., Paparella, M., Gallieni, M., Minetti, E., Bisegna, S., Righetti, M., Badalamenti, S., Alberghini, E., Bertoli, S., Fabbrini, P., Albrizio, P., Rampino, T., Colturi, C., Rombola, G., Lucatello, A., Guerrini, E., Ranghino, A., Lenci, F., Fanciulli, E., Santarelli, S., Damiani, C., Garofalo, D., Sopranzi, F., Santoferrara, A., Di Luca, M., Galiotta, P., Brigante, M., Manganaro, M., Maffei, S., Berto, I., Besso, L., Viglino, G., Cusinato, S., Chiarinottichiappero, D. F., Tognarelli, G., Gianoglio, B., Forneris, G., Biancone, L., Savoldi, S., Vitale, C., Boero, R., Filiberti, O., Borzumati, M., Gesualdo, L., Lomonte, C., Gernone, G., Pallotta, G., Di Paolo, S., Vernaglione, L., Specchio, A., Stallone, G., Dell'Aquila, R., Sandri, G., Russo, F., Napoli, M., Marangi, A., Morrone, L., Di Stratis, C., Fresu, A., Cicu, F., Murtas, S., Manca, O., Pani, A., Pilloni, M., Pistis, R., Cadoni, M., Contu, B., Logias, F., Ivaldi, R., Fancello, S., Cossu, M., Lepori, G., Vittoria, S., Battiati, E., Arnone, M., Rome, M., Barbera, A., Granata, A., Collura, G., Dico, C. L., Pugliese, G., Di Natale, E., Rizzari, G., Cottone, L., Longo, N., Battaglia, G., Marcantoni, C., Giannetto, G., Tumino, G., Randazzo, F., Bellissimo, L., Faro, F. L., Grippaldi, F., Urso, S., Quattrone, G., Todaro, I., Vincenzo, D., Murgo, A., Masuzzo, M., Pisacane, A., Monardo, P., Pontorierro, M., Quari, C., Bauro, A., Chimenz, R. R., Alfio, D., Girasole, F., Cascio, A. L., Caviglia, A., Tornese, F., Sirna, F., Altieri, C., Cusumano, R., Saveriano, V., La Corte, A., Locascio, G., Rotolo, U., Musso, S., Risuglia, L., Blanco, G., Minardo, G., Castellino, S., Zappulla, Z., Randone, S., Di Francesca, M., Cassetti, C. C., Oddo, G., Buscaino, G., Mucaria, F., Barraco, V. I., Di Martino, A., Rallo, D., Dani, L., Campolo, G., Manescalchi, F., Biagini, M., Agate, M., Panichi, V., Casani, A., Traversari, L., Garosi, G., Tabbi, M., Selvi, A., Cencioni, L., Fagugli, R., Timio, F., Leveque, A., Manes, M., Mennella, G., Calo, L., Fiorini, F., Abaterusso, C., Calzavara, P., Meneghel, G., Bonesso, C., Gambaro, G., Gammaro, L., Rugiu, C., Ronco, C., Nordio M., Reboldi G., Di Napoli A., Quintaliani G., Alberici F., Postorino M., Aucella F., Messa P., Brunori G., Bosco M., Malberti F., Mandreoli M., Mazzaferro S., Movilli E., Ravera M., Salomone M., Santoro D., PostorinoLimido M.A., Bonomini M., Stingone A., Maccarone M., Di Loreto E., Stacchiotti L., Malandra R., Chiarella S., D'Agostino F., Fuiano G., Nicodemo L., Bonofiglio R., Greco S., Mallamaci F., Barreca E., Caserta C., Bruzzese V., Galati D., Tramontana D., Viscione M., Chiuchiolo L., Tuccillo S., Sepe M., Vitale F., Ciriana E., Martignetti V., Caserta D., Stizzo A., Romano A., Iulianiello G., Cascone E., Minicone P., Chiricone D., Delgado G., Barbato A., Celentano S., Molfino I., Coppola S., Raiola I., Abategiovanni M., Borrelli S., Margherita C., Bruno F., Ida M., Aliperti E., Potito D., Cuomo G., De Luca M., Merola M., Botta C., Garofalo G., Alinei P., Paglionico C., Roano M., Vitale S., Ierardi R., Fimiani V., Conte G., Di Natale G., Romano M., Di Marino V., Scafarto A., Meccariello S., Pecoraro C., Di Stazio E., Di Meglio E., Cuomo A., Maresca B., Rotaia E., Capasso G., Auricchio M., Pluvio C., Maddalena L., De Maio A., Palladino G., Buono F., Gigliotti G., Mancini E., La Manna G., Storari A., Mosconi G., Cappelli G., Scarpioni R., Gregorini M., Rigotti A., Mancini W., Bianco F., Boscutti G., Amici G., Tosto M., Fini R., Pace G., Cioffi A., Boccia E., Di Lullo L., Di Zazzo G., Simonelli R., Bondatti F., Miglio L., Rifici N., Treglia A., Muci M., Baldinelli G., Rizzi E., Lonzi M., De Cicco C., Forte F., De Paolis P., Grandaliano G., Cuzziol C., Torre V.M., Sfregola P., Rossi V., Fabio G., Flammini A., Filippini A., Onorato L., Vendola F., Di Daniela N., Alfarone C., Scabbia L., Ferrazzano M., Grotta B.D., Gamberini M., Fazzari L., Mene P., Morgia A., Catucci A., Palumbo R., Puliti M., Marinelli R., Polito P., Marrocco F., Morabito S., Rocca R., Nazzaro L., Lavini R., Iamundo V., Chiappini M., Casarci M., Morosetti M., Hassan S., Firmi G., Galliani M., Serraiocco M., Feriozzi S., Valentini W., Sacco P., Garibotto G., Cappelli V., Saffioti C., Repetto M., Rolla D., Lorenz M., Pedrini L., Polonioli D., Galli E., Ruggenenti P., Scolari F., Bove S., Costantino E., Bracchi M., Mangano S., Depetri G., La Milia V., Farina M., Zecchini S., Savino R., Melandri M., Guastoni C., Paparella M., Gallieni M., Minetti E., Bisegna S., Righetti M., Badalamenti S., Alberghini E., Bertoli S., Fabbrini P., Albrizio P., Rampino T., Colturi C., Rombola G., Lucatello A., Guerrini E., Ranghino A., Lenci F., Fanciulli E., Santarelli S., Damiani C., Garofalo D., Sopranzi F., Santoferrara A., Di Luca M., Galiotta P., Brigante M., Manganaro M., Maffei S., Berto I., Besso L., Viglino G., Cusinato S., ChiarinottiChiappero D.F., Tognarelli G., Gianoglio B., Forneris G., Biancone L., Savoldi S., Vitale C., Boero R., Filiberti O., Borzumati M., Gesualdo L., Lomonte C., Gernone G., Pallotta G., Di Paolo S., Vernaglione L., Specchio A., Stallone G., Dell'Aquila R., Sandri G., Russo F., Napoli M., Marangi A., Morrone L., Di Stratis C., Fresu A., Cicu F., Murtas S., Manca O., Pani A., Pilloni M., Pistis R., Cadoni M., Contu B., Logias F., Ivaldi R., Fancello S., Cossu M., Lepori G., Vittoria S., Battiati E., Arnone M., Rome M., Barbera A., Granata A., Collura G., Dico C.L., Pugliese G., Di Natale E., Rizzari G., Cottone L., Longo N., Battaglia G., Marcantoni C., Giannetto G., Tumino G., Randazzo F., Bellissimo L., Faro F.L., Grippaldi F., Urso S., Quattrone G., Todaro I., Vincenzo D., Murgo A., Masuzzo M., Pisacane A., Monardo P., Pontorierro M., Quari C., Bauro A., Chimenz R.R., Alfio D., Girasole F., Cascio A.L., Caviglia A., Tornese F., Sirna F., Altieri C., Cusumano R., Saveriano V., La Corte A., Locascio G., Rotolo U., Musso S., Risuglia L., Blanco G., Minardo G., Castellino S., Zappulla Z., Randone S., Di Francesca M., Cassetti C.C., Oddo G., Buscaino G., Mucaria F., Barraco V.I., Di Martino A., Rallo D., Dani L., Campolo G., Manescalchi F., Biagini M., Agate M., Panichi V., Casani A., Traversari L., Garosi G., Tabbi M., Selvi A., Cencioni L., Fagugli R., Timio F., Leveque A., Manes M., Mennella G., Calo L., Fiorini F., Abaterusso C., Calzavara P., Meneghel G., Bonesso C., Gambaro G., Gammaro L., Rugiu C., and Ronco C.

Subjects
Male, Contextual analysis, medicine.medical_treatment, Population, 030232 urology & nephrology, Recursive partitioning, 030204 cardiovascular system & hematology, Rate ratio, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Classification tree, COVID-19, Renal replacement therapy, Risk Factors, Medical, Surveys and Questionnaires, Health care, medicine, Settore MED/14 - NEFROLOGIA, Humans, education, Pandemics, Societies, Medical, Female, Italy, Nephrology, education.field_of_study, business.industry, Multilevel model, Decision rule, Confidence interval, Original Article, Hemodialysis, business, Contextual analysi, Societies, Demography
Abstract

Background and aim: Over 80% (365/454) of the nation’s centers participated in the Italian Society of Nephrology COVID-19 Survey. Out of 60,441 surveyed patients, 1368 were infected as of April 23rd, 2020. However, center-specific proportions showed substantial heterogeneity. We therefore undertook new analyses to identify explanatory factors, contextual effects, and decision rules for infection containment. Methods: We investigated fixed factors and contextual effects by multilevel modeling. Classification and Regression Tree (CART) analysis was used to develop decision rules. Results: Increased positivity among hemodialysis patients was predicted by center location [incidence rate ratio (IRR) 1.34, 95% confidence interval (CI) 1.20–1.51], positive healthcare workers (IRR 1.09, 95% CI 1.02–1.17), test-all policy (IRR 5.94, 95% CI 3.36–10.45), and infected proportion in the general population (IRR 1.002, 95% CI 1.001–1.003) (all p < 0.01). Conversely, lockdown duration exerted a protective effect (IRR 0.95, 95% CI 0.94–0.98) (p < 0.01). The province-contextual effects accounted for 10% of the total variability. Predictive factors for peritoneal dialysis and transplant cases were center location and infected proportion in the general population. Using recursive partitioning, we identified decision thresholds at general population incidence ≥ 229 per 100,000 and at ≥ 3 positive healthcare workers. Conclusions: Beyond fixed risk factors, shared with the general population, the increased and heterogeneous proportion of positive patients is related to the center’s testing policy, the number of positive patients and healthcare workers, and to contextual effects at the province level. Nephrology centers may adopt simple decision rules to strengthen containment measures timely.

Published
2021

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