532 results on '"Roscigno, M"'
Search Results
202. 696 COMPARISON PROSTATE CANCER DETECTION RATE BETWEEN PROSTATE BIOPSY PERFORMED WITH END-FIRE SINGLE-PLANE AND DUAL-PLANE TRANSRECTAL PROBE
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Raber, M., primary, Scattali, V., additional, Roscigno, M., additional, Dehò, F., additional, Abdollah, F., additional, Gallina, A., additional, Karakiewicz, P., additional, Suardi, N., additional, Rigatti, P., additional, and Montarsi, F., additional
- Published
- 2007
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203. V4 RENAL CELL CARCINOMA WITH CAVO-ATRIAL THROMBOSIS, PARTIALLY OBSTRUCTING THE TRICUSPID VALVE: SURGICAL TECHNIQUE
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Bertini, R., primary, Suardi, N., additional, Mazzoccoli, B., additional, Roscigno, M., additional, Strada, E., additional, Petralia, G., additional, Da Pozzo, L., additional, Colombo, R., additional, Bocciardi, A., additional, Moriggia, S., additional, and Rigatti, P., additional
- Published
- 2007
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204. 697 EXTENDED 24-SAMPLE TRUS PROSTATIC NEEDLE BIOPSY PROTOCOL FOR PROSTATE CANCER DETECTION AS INITIAL DIAGNOSTIC STRATEGY
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Raber, M., primary, Scattoni, V., additional, Roscigno, M., additional, Dehò, F., additional, Suardi, N., additional, Salonia, A., additional, Briganti, A., additional, Gallina, A., additional, Rigatti, P., additional, and Montorsi, F., additional
- Published
- 2007
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205. 250 SAFETY OF SURGERY FOR NODAL RECURRENCE OF PROSTATE CANCER AFTER RADICAL RETROPUBIC PROSTATECTOMY
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Suardi, N., primary, Scattarli, V., additional, Briganti, A., additional, Petralia, G., additional, Salonia, A., additional, Roscigno, M., additional, Bocciardi, A., additional, Da Pozzo, L.F., additional, Montarsi, F., additional, and Rigatti, P., additional
- Published
- 2007
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206. 911Renal cell carcinoma with neoplastic thrombosis of the intrahepatic, suprahepatic inferior vena cava and/or right atrium: Patient selection, surgical technique and oncological radicality
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Bertini, R., primary, Roscigno, M., additional, Pasta, A., additional, Sangalli, M., additional, Mazzoccoli, B., additional, Da Pozzo, L., additional, Colombo, R., additional, Lapenna, E., additional, and Rigatti, P., additional
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- 2005
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207. 297Vesico-urethral anastomosis biopsy in patients undergoing salvage radiation therapy in case of PSA failure after radical prostatectomy: When and why?
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Roscigno, M., primary, Cozzarini, C., additional, Scattoni, V., additional, Da Pozzo, L., additional, Sangalli, M., additional, Colombo, R., additional, Bocciardi, A., additional, Montorsi, F., additional, Villa, E., additional, and Rigatti, P., additional
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- 2005
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208. 289Is hormonal therapy indicated in addition to early adjuvant radiotherapy after radical prostatectomy? Results of an Italian, retrospective, mono-institutional trial on 198 patients
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Roscigno, M., primary, Cozzarini, C., additional, Bertivi, R., additional, Da Pozzo, L., additional, Scattoni, V., additional, Colombo, R., additional, Mazzoccoli, B., additional, Bocciardi, A., additional, Rosso, A., additional, Montorsi, F., additional, Villa, E., additional, and Rigatti, P., additional
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- 2005
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209. 294Impact of 3D conformal therapy on toxicity and clinical outcome in a single-institution series of 390 patients treated with adjuvant or salvage radiotherapy after radical prostatectomy
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Cozzarini, C., primary, Bolognesi, A., additional, Roscigno, M., additional, Bertini, R., additional, Da Pozzo, L., additional, Pasta, A., additional, Bocciardi, A., additional, Montorsi, F., additional, Villa, E., additional, and Rigatti, P., additional
- Published
- 2005
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210. Early adjuvant irradiation following radical surgery for PT3-PT4 pn0 adenocarcinoma of the prostate: Significant reduction of the risk of systemic failure with high doses and timely irradiation. A single institute experience on 175 cases
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COZZARINI, C, primary, FIORINO, C, additional, BOLOGNESI, A, additional, ROSSO, A, additional, BERTINI, R, additional, BUA, L, additional, COLOMBO, R, additional, DAPOZZO, L, additional, MONTORSI, F, additional, and ROSCIGNO, M, additional
- Published
- 2004
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211. 602 ‘Nerve and seminal sparing’ cystectomy and standard cystoprostatectomy with orthotopic neobladder: Clinical and functional outcomes in a cross sectional study
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Colombo, R., primary, Bertini, R., additional, Salonia, A., additional, Naspro, R., additional, Mazzoccoli, B., additional, Ghezzi, M., additional, Roscigno, M., additional, Pasta, A., additional, and Rigatti, P., additional
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- 2004
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212. 260 Isolated mono- and pluri-focal high grade prostatic intraepithelial neoplasia (HGPIN) on initial extended prostate needle biopsies: factors predicting cancer detection on extended re-biopsy
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Roscigno, M., primary, Scattoni, V., additional, Freschi, M., additional, Pasta, A., additional, Colombo, R., additional, Bertini, R., additional, Montorsi, F., additional, and Rigatti, P., additional
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- 2004
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213. 672 General vs. spinal anaesthesia with different types of sedation in patients undergoing radical retropubic prostatectomy: Results of a prospective randomized trial
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Salonia, A., primary, Suardi, N., additional, Crescenti, A., additional, Zanni, G., additional, Bertini, R., additional, Bocciardi, A.M., additional, Colombo, R., additional, Da Pozzo, L., additional, Di Girolamo, V., additional, Roscigno, M., additional, Rigatti, P., additional, and Montorsi, F., additional
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- 2004
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214. 814 Antimicrobial prophylaxis in patients undergoing clean- contaminated urologic-oncologic procedures
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Bertini, R., primary, Zanni, G., additional, Roscigno, M., additional, Ghezzi, M., additional, Da Pozzo, L., additional, Colombo, R., additional, Bocciardi, A., additional, Sangalli, M., additional, Montorsi, f., additional, and Rigatti, P., additional
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- 2004
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215. 262 Atypical small acinar proliferation on initial extended prostate biopsy: Cancer detection on second and third extended biopsy
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Scattoni, V., primary, Roscigno, M., additional, Freschi, M., additional, Dehò, F., additional, Raber, M., additional, Briganti, A., additional, Fantini, G., additional, Potenzoni, M., additional, Rigatti, P., additional, and Montorsi, F., additional
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- 2004
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216. 698 Extended lymph-node dissection in patients with muscle-invasive transitional cell carcinoma of the upper urinary tract: When and why?
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Bertini, R., primary, Cozzarini, C., additional, Roscigno, M., additional, Da Pozzo, L., additional, Pasta, A., additional, Mazzoccoli, B., additional, Colombo, R., additional, Villa, E., additional, and Rigatti, P., additional
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- 2004
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217. 255 The impact of prostate gland volume on prostate cancer detection by means of extended needle biopsy and re-biopsy
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Scattoni, V., primary, Roscigno, M., additional, Freschi, M., additional, Raber, M., additional, Dehò, F., additional, Montorsi, F., additional, Salonia, A., additional, Briganti, A., additional, Fantini, G., additional, and Rigatti, P., additional
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- 2004
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218. 783 Local anaesthesia in trans-rectal biopsy of prostate: EMLA® vs. placebo
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Raber, M., primary, Scattoni, V., additional, Roscigno, M., additional, Dehò, F., additional, Briganti, A., additional, Salonia, A., additional, Rigatti, P., additional, and Montorsi, F., additional
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- 2004
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219. Improved survival in patients with muscle-invasive transitional cell carcinoma of the upper urinary tract treated with lymph nodes dissection
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Bertini, R., primary, Cozzarini, C., additional, Roscigno, M., additional, Colombo, R., additional, Da Pozzo, L., additional, Di Girolamo, V., additional, Potenzoni, M., additional, Pasta, A., additional, Villa, E., additional, and Rigatti, P., additional
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- 2003
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220. Follow-up of patients with isolated mono and plurifocal High Grade Prostatic Intraepithelial Neoplasia (HGPIN) on initial prostate needle biopsy
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Roscigno, M., primary, Scattoni, V., additional, Freschi, M., additional, Raber, M., additional, Colombo, R., additional, Bertini, R., additional, Ghezzi, M., additional, Montorsi, F., additional, and Rigatti, P., additional
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- 2002
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221. Thermo–Chemotherapy and Electromotive Drug Administration of Mitomycin C in Superficial Bladder Cancer Eradication
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Colombo, R., primary, Colombo, R., additional, Brausi, M., additional, Da Pozzo, L.F., additional, Salonia, A., additional, Montorsi, F., additional, Scattoni, V., additional, Roscigno, M., additional, and Rigatti, P., additional
- Published
- 2001
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222. Lymphovascular invasion predicts clinical outcomes in patients with node-negative upper tract urothelial carcinoma.
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Kikuchi E, Margulis V, Karakiewicz PI, Roscigno M, Mikami S, Lotan Y, Remzi M, Bolenz C, Langner C, Weizer A, Montorsi F, Bensalah K, Koppie TM, Fernández MI, Raman JD, Kassouf W, Wood CG, Suardi N, Oya M, and Shariat SF
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- 2009
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223. [Diagnostic value of ultrasound-guided anastomotic biopsies in patients with high PSA (> or = 0,4 ng/ml) after radical prostatectomy]
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Scattoni V, Roscigno M, Raber M, Montorsi F, Bertini R, Bua L, Luigi Filippo Da Pozzo, Rigatti P, Scattoni, V, Roscigno, M, Raber, M, Montorsi, F, Bertini, R, Bua, L, Da Pozzo, L, and Rigatti, P
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prostate cancer, biopsy, radical prostatectomy, anastomosis - Abstract
OBJECTIVES: The authors report their experience on the use of a high number of biopsies for the diagnosis of a vesicourethral anastomosis tumor recurrence in patients who underwent radical prostatectomy with a PSA elevation. METHODS: Sixty-five patients with PSA > or = 0.4 ng/ml after radical prostatectomy received 6 to 8 transrectal ultrasound (TRUS) guided biopsies of the vesicourethral anastomosis. RESULTS: The biopsy scheme with 6 random anastomotic biopsies plus additional biopsies through TRUS detectable lesions was able to diagnose a local recurrence in more than 60% of the cases. In presence of a post-operative PSA < 1.0 ng/ml and in absence of ultrasound detectable or palpable lesions a local neoplastic recurrence was detected in 58% of the cases. In presence of a palpable or ultrasound visible lesions, the detection rate increases to 80% of the cases.
224. Detection and diagnosis of prostate cancer: what's new
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Scattoni, V., Sangalli, M., Roscigno, M., Raber, M., Andrea Gallina, Fabbri, F., Saccà, A., Salonia, A., Montorsi, F., Rigatti, P., Scattoni, V., Sangalli, M., Roscigno, M., Raber, M., Gallina, A., Fabbri, F., Saccà, A., Salonia, A., Montorsi, Francesco, and Rigatti, P.
225. TEN-YEAR OUTCOME OF PATIENTS RECEIVING THREE-PIECE PENILE IMPLANT FOR PEYRONIE'S DISEASE AND THEIR PARTNERS: RESULTS OF A PROSPECTIVE STUDY
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Montorsi, F., Dehò, F., Salonia, A., Briganti, A., Barbieri, L., Zanni, G., Scattoni, V., Roscigno, M., and Rigatti, P.
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- 2006
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226. INTEGRATED 11C-CHOLINE PET/CT SCAN IN THE EVALUATION OF PATIENTS WITH BIOCHEMICAL FAILURE AFTER RADICAL RETROPUBIC PROSTATECTOMY: HYSTOLOGICAL CORRELATIONS AFTER PELVIC AND RETROPERITONEAL LYMPHO-NODE DISSECTION
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Scattoni, V., Suardi, N., Picchio, M., Messa, C., Freschi, M., Roscigno, M., Da Pozzo, L., Fazio, F., Montorsi, F., and Rigatti, P.
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- 2006
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227. ENUCLEORESECTION FOR RENAL CELL CARCINOMA: PROGNOSTIC FACTORS AND LONG-TERM RESULTS IN PATHOLOGICAL T1-STAGE PATIENTS
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Bertini, R., Roscigno, M., Cozzarini, C., Sangalli, M., Pasta, A., Mazzoccoli, B., Angiolilli, D., Da Pozzo, L., Colombo, R., Bocciardi, A., and Rigatti, P.
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- 2006
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228. Predicting positive surgical margins in partial nephrectomy: a prospective multicenter observational study ( the RECORD 2 project)
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Mari, A, Schiavina, R, Brunocilla, E, Gontero, P, Porpiglia, F, Fiori, C, Simeone, C, Antonelli, A, Capitanio, U, Longo, N, Roscigno, M, L imarzi V, Trombetta, C, Siracusano, S, Artibani, W, Ficarra, V, Schips, L, Costantini, E, Bove, P, Celia, A, Simonato, A, Terrone, C, Selli, C, Porreca, A, Carini, M, Bianchi, L, and Minervini, A
229. The role of transrectal ultrasound-guided prostatic biopsies of hypoechoic areas associated with systematic biopsies in patients with normal and elevated PSA values,II ruolo delle biopsie prostatiche mirate sulle aree ipoecogene associate alle biopsie a sestanti nei pazienti con PSA elevato e nella norma
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Scattoni, V., Roscigno, M., Raber, M., Consonni, P., Freschi, M., Montorsi, F., Pasta, A., Renzo Colombo, Nava, L., Bua, L., and Rigatti, P.
230. INDEPENDENT VALIDATION OF THE 2010 TNM STAGING SYSTEM FOR RENAL CELL CARCINOMA: DOES IT IMPROVES PREDICTIVE ACCURACY IN CANCER-SPECIFIC MORTALITY COMPARED TO 2002 TNM?
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Roscigno, M., Shariat, S. F., May, M., Novara, G., Zigeuner, R., Schips, L., OTTAVIO DE COBELLI, Rocco, B., Nunzio, C., Feciche, B., Truss, M., Pahernik, S., Wirth, M. P., Longo, N., Simonato, A., Serni, S., Siracusano, S., Volpe, A., Morgia, G., Martorana, G., Francesco, M., Ficarra, V., and Brookman-May, S.
231. The role of transrectal ultrasound of the prostatic fossa in the diagnosis of local recurrence after radical prostatectomy in case of PSA failure,Ii ruolo dell'ecografia della loggia prostatica nella diagnosi delle recidive locali dopo prostatectomia radicale in caso di rialzo del PSA
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Roscigno, M., Scattoni, V., Raber, M., Consonni, P., Montorsi, F., Pasta, A., Bertini, R., Renzo Colombo, Da Pozzo, L., Freschi, M., and Rigatti, P.
232. P208 - Ultrasound/MRI fusion prostate biopsies with Esaote Virtual Navigator System: A multicentric italian experience.
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Roscigno, M., La Croce, G., Dehò, F., Naselli, A., Marra, G., Stabile, A., Gontero, P., Montorsi, F., and Da Pozzo, L.
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ULTRASONIC imaging , *MAGNETIC resonance imaging , *BIOPSY , *TERTIARY care , *DESCRIPTIVE statistics - Published
- 2018
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233. P88 - Magnetic resonance imaging and ultrasound fusion biopsy in follow-up of patients in active surveillance protocol.
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Roscigno, M., Nicolai, M., Perugini, G., Querques, G., La Croce, G., Deiana, G., Chinaglia, D., Sironi, S., and Da Pozzo, L.
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MAGNETIC resonance imaging , *PROSTATE cancer , *BIOPSY , *SEXTANTS , *RECEIVER operating characteristic curves - Published
- 2018
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234. Herniation of the amniotic sac into the bladder through a vesico-uterine fistula in the 32nd week of pregnancy
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Bertini, R., Roscigno, M., Colombo, R., Spagnolo, D., Ferrari, A., and Rigatti, P.
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- 2001
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235. 999 PREOPERATIVE FACTORS PREDICTING LYMPH NODE INVASION IN PATIENTS WITH UPPER TRACT TRANSITIONAL CELL CARCINOMA
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Roscigno, M., Shariat, S.F., Bertini, R., Karakiewizc, P., Suardi, N., Wood, C.G., Guo, C.C., Margulis, V., Wheat, J., Weizer, A., Langner, C., Zigeuner, R., Rigatti, P., Murai, M., Kikuchi, E., Kabbani, W., Lotan, Y., Raman, J.D., Casey, K.Ng., and Strobel, P.
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- 2008
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236. 601 MORE EXTENSIVE LYMPHADENECTOMY IMPROVES THE PROGNOSIS OF PATIENTS WITH UPPER TRACT UROTHELIAL CARCINOMA WITHOUT NODAL METASTASES
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Roscigno, M., Shariat, S.F., Bertini, R., Freschi, M., Remzi, M., Haitel, A., Margulis, V., Guo, C.C., Wood, C.G., Kikuchi, E., Murai, M., Zigeuner, R., Langner, C., Weizer, A., Wheat, J., Bolenz, C., Strobel, P., Lotan, Y., Kabbani, W., and Koppie, T.M.
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- 2008
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237. Perioperative and Mid-term Oncological and Functional Outcomes After Partial Nephrectomy for Complex (PADUA Score ≥10) Renal Tumors: A Prospective Multicenter Observational Study (the RECORD2 Project)
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Francesco Porpiglia, Enrico Checcucci, Maria Furlan, Vincenzo Ficarra, Paolo Gontero, Umberto Capitanio, Marco Carini, Salvatore Siracusano, Alessandro Antonelli, Marco Roscigno, Eugenio Brunocilla, Fabrizio Di Maida, Riccardo Tellini, Claudio Simeone, Simone Francavilla, Cristian Fiori, Roberto Bertini, Daniele Amparore, Luigi F. Da Pozzo, Riccardo Schiavina, Andrea Minervini, Andrea Mari, Nicola Longo, Mari A., Tellini R., Porpiglia F., Antonelli A., Schiavina R., Amparore D., Bertini R., Brunocilla E., Capitanio U., Checcucci E., Da Pozzo L., Di Maida F., Fiori C., Francavilla S., Furlan M., Gontero P., Longo N., Roscigno M., Simeone C., Siracusano S., Ficarra V., Carini M., Minervini A., Mari, A., Tellini, R., Porpiglia, F., Antonelli, A., Schiavina, R., Amparore, D., Bertini, R., Brunocilla, E., Capitanio, U., Checcucci, E., Da Pozzo, L., Di Maida, F., Fiori, C., Francavilla, S., Furlan, M., Gontero, P., Longo, N., Roscigno, M., Simeone, C., Siracusano, S., Ficarra, V., Carini, M., and Minervini, A.
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medicine.medical_specialty ,Complications ,Urology ,medicine.medical_treatment ,Complexity ,Ischemia ,Nephron-sparing surgery ,Partial nephrectomy ,Renal cell carcinoma ,Robotics ,Trifecta ,030232 urology & nephrology ,Renal function ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Complexity, Complications, Ischemia, Nephron-sparing surgery, Partial nephrectomy, Renal cell carcinoma, Robotics, Trifecta ,Radical surgery ,business.industry ,Proportional hazards model ,Hazard ratio ,renal carcinoma ,Odds ratio ,Perioperative ,medicine.disease ,Nephrectomy ,Surgery ,Robotic ,030220 oncology & carcinogenesis ,business ,Complication - Abstract
Background: Partial nephrectomy (PN) for complex renal masses has a non-negligible risk of perioperative complications. Furthermore, late functional and oncological outcomes of patients submitted to these challenging surgeries still remain to be determined. Objectives: To report the perioperative and mid-term oncological and functional outcomes of PN for complex masses (Preoperative Aspects and Dimensions Used for an Anatomical [PADUA] score ≥ 10) in a large multicenter prospective observational study. Design, setting, and participants: We prospectively evaluated patients treated with PN for complex renal tumors at 26 urological centers (Registry of Conservative and Radical Surgery for Cortical Renal Tumor Disease [RECORD2] project). Outcome measurements and statistical analysis: Multivariate logistic regression analyses explored the predictors of surgical complications. Multivariable Cox regression analyses estimated the hazard of renal function loss and disease recurrence. Kaplan-Meier estimates assessed the probability of survival. Results and limitations: In total, 410 patients who underwent PN for complex masses were evaluated. Clinical T1b and T2 tumors accounted for 43.2% and 9.8% of the cases. Overall, 45.9%, 18.8%, and 35.4% of patients underwent open, laparoscopic, and robotic PN, respectively. Intraoperative complications occurred in 15 (3.6%) patients, while postoperative surgical complications were recorded in 76 (18.5%) patients. At multivariable analysis, preoperative hemoglobin (odds ratio [OR]: 0.67; p < 0.001) and open (OR: 3.91; p < 0.001) versus robotic surgical approach were found to be the only predictors of surgical complications. An estimated glomerular filtration rate drop of >25% from baseline was observed in 30.2% and 17.6% of patients at 1st month and 2 yr after surgery, respectively. Two-year recurrence-free survival was 97.1%; positive surgical margins (hazard ratio [HR]: 3.35; p = 0.009), nucleolar grading (HR: 5.61; p < 0.001), and tumor stage (HR: 2.62; p = 0.05) were associated with recurrence. Conclusions: In a large series, PN for complex renal masses was a safe technique with an acceptable rate of perioperative complications and excellent mid-term oncological and functional results. Patient summary: In this study, we evaluated peri- and postoperative outcomes of patients treated with partial nephrectomy for complex renal masses. Open surgery was associated with higher complications than the robotic approach. Some histological features were found to be associated with disease recurrence.
- Published
- 2021
238. P247 - Do incidental prostate cancer patients managed with active surveillance exhibit different disease features and outcomes compared to their biopsy-diagnosed counterparts? Results of a multi-institutional study.
- Author
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Leni, R., Stabile, A., Capitanio, U., Roscigno, M., La Croce, G., Da Pozzo, L.F., Olivier, J., Zattoni, F., Facco, M., Dal Moro, F., Van Den Bergh, R., Soeterik, T., Bianchi, L., Lampariello, L., Salonia, A., Montorsi, F., Briganti, A., Vickers, A., and Gandaglia, G.
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PROSTATE cancer patients , *WATCHFUL waiting , *PROSTATE cancer - Published
- 2024
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239. Transperitoneal vs retroperitoneal minimally invasive partial nephrectomy: comparison of perioperative outcomes and functional follow-up in a large multi-institutional cohort (The RECORD 2 Project)
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Vincenzo Altieri, Daniele Amparore, Riccardo Rizzetto, Alessandro Larcher, Sergio Serni, G. Grosso, Cesare Selli, Matteo Ferro, Giuseppe Vespasiani, Bernardo Rocco, Alchiede Simonato, Nicola Longo, Luigi Schips, Marco Carini, Angelo Porreca, Francesco Berardinelli, Salvatore Siracusano, Carlo Terrone, Mario Falsaperla, A. Volpe, Antonio Celia, F. Di Maida, Umberto Capitanio, R. Tellini, Carlo Trombetta, Claudio Simeone, Alessandro Antonelli, A. Diminutto, V. Li Marzi, Francesco Porpiglia, Giancarlo Marra, P. Bove, Donata Villari, F. Montorsi, L. Da Pozzo, Eugenio Brunocilla, A. Polara, Andrea Minervini, Maria Furlan, Vincenzo Ficarra, M. Roscigno, P. Gontero, Elisabetta Costantini, Walter Artibani, Carla Fiori, Riccardo Schiavina, Andrea Mari, Porpiglia, F., Mari, A., Amparore, D., Fiori, C., Antonelli, A., Artibani, W., Bove, P., Brunocilla, E., Capitanio, U., Da Pozzo, L., Di Maida, F., Gontero, P., Longo, N., Marra, G., Rocco, B., Schiavina, R., Simeone, C., Siracusano, S., Tellini, R., Terrone, C., Villari, D., Ficarra, V., Carini, M., Minervini, A., Altieri, V., Berardinelli, F., Celia, A., Costantini, E., Diminutto, A., Falsaperla, M., Ferro, M., Furlan, M., Grosso, G., Larcher, A., Li Marzi, V., Montorsi, F., Polara, A., Porreca, A., Rizzetto, R., Roscigno, M., Schips, L., Selli, C., Serni, S., Simonato, A., Trombetta, C., Vespasiani, G., Volpe, A., Francesco Porpiglia, Andrea Mari, Daniele Amparore, Cristian Fiori, Alessandro Antonelli, Walter Artibani, Pierluigi Bove, Eugenio Brunocilla, Umberto Capitanio, Luigi Da Pozzo, Fabrizio Di Maida, Paolo Gontero, Nicola Longo, Giancarlo Marra, Bernardo Rocco, Riccardo Schiavina, Claudio Simeone, Salvatore Siracusano, Riccardo Tellini, Carlo Terrone, Donata Villari, Vincenzo Ficarra, Marco Carini, Andrea Minervini, Vincenzo Altieri, Francesco Berardinelli, Antonio Celia, Elisabetta Costantini, Alberto Diminutto, Mario Falsaperla, Matteo Ferro, Maria Furlan, Gaetano Grosso, Alessandro Larcher, Vincenzo Li Marzi, Francesco Montorsi, Andrea Polara, Angelo Porreca, Riccardo Rizzetto, Marco Roscigno, Luigi Schip, Cesare Selli, Sergio Serni, Alchiede Simonato, Carlo Trombetta, Giuseppe Vespasiani, Alessandro Volpe, Porpiglia F., Mari A., Amparore D., Fiori C., Antonelli A., Artibani W., Bove P., Brunocilla E., Capitanio U., Da Pozzo L., Di Maida F., Gontero P., Longo N., Marra G., Rocco B., Schiavina R., Simeone C., Siracusano S., Tellini R., Terrone C., Villari D., Ficarra V., Carini M., Minervini A., Altieri V., Berardinelli F., Celia A., Costantini E., Diminutto A., Falsaperla M., Ferro M., Furlan M., Grosso G., Larcher A., Li Marzi V., Montorsi F., Polara A., Porreca A., Rizzetto R., Roscigno M., Schips L., Selli C., Serni S., Simonato A., Trombetta C., Vespasiani G., and Volpe A.
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medicine.medical_specialty ,Intraoperative Complication ,Urology ,medicine.medical_treatment ,Operative Time ,Surgical approach ,030232 urology & nephrology ,Minimally invasive partial nephrectomy, Renal cell carcinoma, Retroperitoneal, Surgical approach, Transperitoneal ,lcsh:RC870-923 ,lcsh:RC254-282 ,Nephrectomy ,Article ,03 medical and health sciences ,0302 clinical medicine ,Renal cell carcinoma ,medicine ,Minimally invasive partial nephrectomy ,Retroperitoneal ,Transperitoneal ,Humans ,Retroperitoneal Space ,Retrospective Studies ,business.industry ,Perioperative ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Kidney Neoplasms ,Surgery ,Settore MED/24 ,Treatment Outcome ,030220 oncology & carcinogenesis ,Propensity score matching ,Cohort ,Laparoscopy ,Positive Surgical Margin ,Follow-Up Studies ,business ,Abdominal surgery - Abstract
Background Aim of this study was to evaluate and compare perioperative outcomes of transperitoneal (TP) and retroperitoneal (TR) approaches in a multi-institutional cohort of minimally invasive partial nephrectomy (MI-PN). Material and methods All consecutive patients undergone MI-PN for clinical T1 renal tumors at 26 Italian centers (RECORd2 project) between 01/2013 and 12/2016 were evaluated, collecting the pre-, intra-, and postoperative data. The patients were then stratified according to the surgical approach, TP or RP. A 1:1 propensity score (PS) matching was performed to obtain homogeneous cohorts, considering the age, gender, baseline eGFR, surgical indication, clinical diameter, and PADUA score. Results 1669 patients treated with MI-PN were included in the study, 1256 and 413 undergoing TP and RP, respectively. After 1:1 PS matching according to the surgical access, 413 patients were selected from TP group to be compared with the 413 RP patients. Concerning intraoperative variables, no differences were found between the two groups in terms of surgical approach (lap/robot), extirpative technique (enucleation vs standard PN), hilar clamping, and ischemia time. Conversely, the TP group recorded a shorter median operative time in comparison with the RP group (115 vs 150 min), with a higher occurrence of intraoperative overall, 21 (5.0%) vs 9 (2.1%); p = 0.03, and surgical complications, 18 (4.3%) vs 7 (1.7%); p = 0.04. Concerning postoperative variables, the two groups resulted comparable in terms of complications, positive surgical margins and renal function, even if the RP group recorded a shorter median drainage duration and hospital length of stay (3 vs 2 for both variables), p Conclusions The results of this study suggest that both TP and RP are feasible approaches when performing MI-PN, irrespectively from tumor location or surgical complexity. Notwithstanding longer operative times, RP seems to have a slighter intraoperative complication rate with earlier postoperative recovery when compared with TP.
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- 2020
240. Predicting positive surgical margins in partial nephrectomy: A prospective multicentre observational study (the RECORd 2 project)
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Riccardo Schiavina, Andrea Mari, Lorenzo Bianchi, Daniele Amparore, Alessandro Antonelli, Walter Artibani, Eugenio Brunocilla, Umberto Capitanio, Cristian Fiori, Fabrizio Di Maida, Paolo Gontero, Alessandro Larcher, Vincenzo Li Marzi, Nicola Longo, Giancarlo Marra, Emanuele Montanari, Francesco Porpiglia, Marco Roscigno, Claudio Simeone, Salvatore Siracusano, Riccardo Tellini, Carlo Terrone, Donata Villari, Vincenzo Ficarra, Marco Carini, Andrea Minervini, Vincenzo Altieri, Francesco Berardinelli, Marco Borghesi, Carlo Andrea Bravi, Pierluigi Bove, Giovanni Enrico Cacciamani, Riccardo Campi, Antonio Celia, Elisabetta Costantini, Luigi Da Pozzo, Mario Falsaperla, Matteo Ferro, Maria Furlan, Simone Sforza, Francesco Marson, Francesco Montorsi, Sebastiano Nazzani, Angelo Porreca, Giorgio Ivan Russo, Luigi Schips, Cesare Selli, Alchiede Simonato, Carlo Trombetta, Schiavina R, Mari A, Bianchi L, Amparore D, Antonelli A, Artibani W, Brunocilla E, Capitanio U, Fiori C, Di Maida F, Gontero P, Larcher A, Li Marzi V, Longo N, Marra G, Montanari E, Porpiglia F, Roscigno M, Simeone C, Siracusano S, Tellini R, Terrone C, Villari D, Ficarra V, Carini M, Minervini A, Collaborators, Schiavina R., Mari A., Bianchi L., Amparore D., Antonelli A., Artibani W., Brunocilla E., Capitanio U., Fiori C., Di Maida F., Gontero P., Larcher A., Li Marzi V., Longo N., Marra G., Montanari E., Porpiglia F., Roscigno M., Simeone C., Siracusano S., Tellini R., Terrone C., Villari D., Ficarra V., Carini M., Minervini A., Altieri V., Berardinelli F., Borghesi M., Bravi C.A., Bove P., Cacciamani G.E., Campi R., Celia A., Costantini E., Da Pozzo L., Falsaperla M., Ferro M., Furlan M., Marson F., Montorsi F., Nazzani S., Porreca A., Russo G.I., Schips L., Selli C., Simonato A., Trombetta C., Schiavina, R., Mari, A., Bianchi, L., Amparore, D., Antonelli, A., Artibani, W., Brunocilla, E., Capitanio, U., Fiori, C., Di Maida, F., Gontero, P., Larcher, A., Li Marzi, V., Longo, N., Marra, G., Montanari, E., Porpiglia, F., Roscigno, M., Simeone, C., Siracusano, S., Tellini, R., Terrone, C., Villari, D., Ficarra, V., Carini, M., Minervini, A., Altieri, V., Berardinelli, F., Borghesi, M., Bravi, C. A., Bove, P., Cacciamani, G. E., Campi, R., Celia, A., Costantini, E., Da Pozzo, L., Falsaperla, M., Ferro, M., Furlan, M., Sforza, S., Marson, F., Montorsi, F., Nazzani, S., Porreca, A., Russo, G. I., Schips, L., Selli, C., Simonato, A., Trombetta, C., Schiavina, Riccardo, Mari, Andrea, Bianchi, Lorenzo, Amparore, Daniele, Antonelli, Alessandro, Artibani, Walter, Brunocilla, Eugenio, Capitanio, Umberto, Fiori, Cristian, Di Maida, Fabrizio, Gontero, Paolo, Larcher, Alessandro, Li Marzi, Vincenzo, Longo, Nicola, Marra, Giancarlo, Montanari, Emanuele, Porpiglia, Francesco, Roscigno, Marco, Simeone, Claudio, Siracusano, Salvatore, Tellini, Riccardo, Terrone, Carlo, Villari, Donata, Ficarra, Vincenzo, Carini, Marco, Minervini, Andrea, and Trombetta, Carlo
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Male ,Neoplasm, Residual ,Databases, Factual ,multicenter prospective observational study ,medicine.medical_treatment ,030232 urology & nephrology ,Nephron-sparing surgery ,Nephrectomy ,Nomogram ,0302 clinical medicine ,Renal cell carcinoma ,Risk Factors ,clinical predictor ,Partial nephrectomy ,Prospective Studies ,Stage (cooking) ,Prospective cohort study ,Surgical margins, Nephron-sparing surgery, Nomogram, Partial nephrectomy, Renal cell carcinoma, Robot-assisted partial nephrectomy ,Surgical margins ,Robot-assisted partial nephrectomy ,Margins of Excision ,General Medicine ,Middle Aged ,Kidney Neoplasms ,Hospitals ,Oncology ,Elective Surgical Procedures ,030220 oncology & carcinogenesis ,Area Under Curve ,Residual ,Female ,positive surgical margin ,Positive Surgical Margin ,Elective Surgical Procedure ,medicine.medical_specialty ,Hospitals, Low-Volume ,High-Volume ,03 medical and health sciences ,Databases ,Internal medicine ,Low-Volume ,medicine ,Humans ,Neoplasm Invasiveness ,Carcinoma, Renal Cell ,Factual ,Aged ,Neoplasm Staging ,business.industry ,Carcinoma ,Renal Cell ,medicine.disease ,Nomograms ,Settore MED/24 ,Logistic Models ,ROC Curve ,Neoplasm ,Surgery ,Observational study ,business ,Hospitals, High-Volume - Abstract
PURPOSE: to evaluate clinical predictors of positive surgical margins (PSMs) in a large multicenter prospective observational study and to develop a clinic nomogram to predict the likelihood of PSMs after partial nephrectomy (PN). MATERIALS AND METHODS: We prospectively evaluated 4308 patients who had surgical treatment for renal tumors between January 2013 and December 2016 at 26 urological Italian Centers (RECORd 2 project). Two multivariable logistic models were evaluated to predict the likelihood of PSMs. Center caseload was dichotomized using a visual assessment adjusted for several predictors of PSMs. A nomogram predicting PSMs was developed. RESULTS: Overall, 2076 patients treated with PN were evaluated. pT1a, pT1b, pT2 and pT3a were recorded in 68.7%, 22.6%, 2.1% and 6.6% of the patients, respectively. PSMs were recorded in 342 (16.5%) patients. From a null multivariable model against number of PN/year, 60 PN/year were identified as the best cut-off to define a high-volume centre. At multivariable analysis, clinical stage (cT1a vs. cT2 [OR 1.94]; p = 0.03), volume centre (≤60 PN/year) (OR 2.22; p
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- 2020
241. Impact of Surgical Approach on Patient-Reported Outcomes after Radical Prostatectomy: A Propensity Score-Weighted Analysis from a Multicenter, Prospective, Observational Study (The Pros-IT CNR Study)
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Antonelli, A., Palumbo, C., Noale, M., Porreca, A., Maggi, S., Simeone, C., Bassi, P., Bertoni, F., Bracarda, S., Buglione, M., Conti, G. N., Corvò, R., Gacci, M., Mirone, V., Montironi, R., Triggiani, L., Tubaro, A., Artibani, W., Crepaldi, G., Graziotti, P., Russi, E., Magrini, Stefano, Muto, M., Pecoraro, G., Ricardi, S., Zagonel, U., Alitto, Anna, Ambrosi, R., Aristei, E., Barbieri, C., Bardari, M., Bardoscia, F., Barra, L., Bartoncini, S., Basso, S., Becherini, U., Bellavita, C., Bergamaschi, R., Berlingheri, F., Berruti, S., Borghesi, M., Bortolus, R., Borzillo, V., Bosetti, D., Bove, G., Bove, P., Brausi, M., Bruni, A., Bruno, G., Brunocilla, E., Buffoli, A., Buttigliero, C., Cacciamani, G., Caldiroli, M., Cardo, G., Carmignani, G., Carrieri, G., Castelli, E., Castrezzati, E., Catalano, G., Cattarino, S., Catucci, F., Cavallini, F. D., Ceccarini, O., Celia, A., Chiancone, F., Chini, T., Cianci, C., Cisternino, A., Collura, D., Corbella, F., Corinti, M., Corsi, P., Cortese, F., Corti, L., Cosimo, De, Cristiano, N., D'Angelillo, O., Pozzo, Da, D'Agostino, L., D'Elia, D., Dandrea, C., Angelis, De, Cobelli, De, Concilio, De, Lisa, De, Luca, De, Stefani, De, Deantoni, A., C. L., Degli, Esposti, Destito, C., Detti, A., Muzio, Di, Stasio, Di, Stefano, Di, Trapani, Di, Difino, D., Falivene, G., Farullo, S., Fedelini, G., Ferrari, P., Ferraù, I., Ferro, F., Fodor, M., Fontana, A., Francesca, F., Francolini, F., Frata, G., Frezza, P., Gabriele, G., Galeandro, P., Garibaldi, M., Gennari, Pietro, Gentilucci, G., Giacobbe, A., Giussani, A., Giusti, L., Gontero, G., Guarneri, P., Guida, A., Gurioli, C., Huqi, A., Imbimbo, D., Ingrosso, C., Iotti, G., Italia, C., Mattina, La, Lamanna, P., Lastrucci, E., Lazzari, L., Liberale, G., Liguori, F., Lisi, G., Lohr, R., Lombardo, F., Lovisolo, R., J. A. J., Ludovico, Giuseppe, Macchione, M., Maggio, N., Malizia, F., Manasse, M., Mandoliti, G., Mantini, G., Marafioti, G., Marciello, L., Marconi, Alberto, Martilotta, M., Marzano, A., Masciullo, S., Maso, S., Massenzo, G., Mazzeo, A., Mearini, E., Medoro, L., Molè, S., Monesi, R., Montanari, G., Montefiore, E., Montesi, F., Morgia, G., Moro, G., Muscas, G., Musio, G., Muto, D., Muzzonigro, P., Napodano, G., Negro, G., Nidini, C. L. A., Ntreta, M., Orsatti, M., Palazzolo, M., Parisi, I., Parma, A., Pavan, P., Pericolini, N., Pinto, M., Pistone, F., Pizzuti, A., Platania, V., Polli, A., Pomara, C., Ponti, G., Porcaro, E., Porpiglia, A. B., Pugliese, F., Pycha, D., Raguso, A., Rampini, G., Randone, Donato, Roboldi, F., Roscigno, V., Ruggieri, M., Ruoppo, M. P., Sanseverino, G., Santacaterina, R., Santarsieri, A., Santoni, M., Scagliarini, R., Scagliotti, Giorgio, Scanzi, V., Scarcia, M., Schiavina, M., Sciarra, R., Sciorio, A., Scolaro, C., Scuzzarella, T., Selvaggio, S., Serao, O., Serni, A., Signor, S., Silvani, M. A., Silvano, M., Silvestris, G., Simone, F., Spagnoletti, V., Spinelli, Matteo, Squillace, G., Tombolini, L., Toninelli, V., Trinchieri, M., Trodella, A., Trodella, L. E., Trombetta, L., Tronnolone, C., Tucci, L., Urzì, M., Valdagni, D., Valeriani, R., Vanoli, M., Vitali, M., Volpe, E., Zaramella, A., Zeccolini, S., Zini, G., Antonelli, A., Palumbo, C., Noale, M., Porreca, A., Maggi, S., Simeone, C., Bassi, P., Bertoni, F., Bracarda, S., Buglione, M., Conti, G. N., Corvo, R., Gacci, M., Mirone, V., Montironi, R., Triggiani, L., Tubaro, A., Artibani, W., Crepaldi, G., Graziotti, P., Russi, E., Magrini Stefano, M., Muto, G., Pecoraro, S., Ricardi, U., Zagonel, V., Alitto Anna, R., Ambrosi, E., Aristei, C., Barbieri, M., Bardari, F., Bardoscia, L., Barra, S., Bartoncini, S., Basso, U., Becherini, C., Bellavita, R., Bergamaschi, F., Berlingheri, S., Berruti, A., Borghesi, M., Bortolus, R., Borzillo, V., Bosetti, D., Bove, G., Bove, P., Brausi, M., Bruni, A., Bruno, G., Brunocilla, E., Buffoli, A., Buttigliero, C., Cacciamani, G., Caldiroli, M., Cardo, G., Carmignani, G., Carrieri, G., Castelli, E., Castrezzati, E., Catalano, G., Cattarino, S., Catucci, F., Cavallini, F. D., Ceccarini, O., Celia, A., Chiancone, F., Chini, T., Cianci, C., Cisternino, A., Collura, D., Corbella, F., Corinti, M., Corsi, P., Cortese, F., Corti, L., de Cosimo, N., Cristiano, O., D'Angelillo, R., Da Pozzo, L., D'Agostino, D., D'Elia, C., Dandrea, M., De Angelis, M., De Angelis, P., De Cobelli, O., De Concilio, B., De Lisa, A., De Luca, S., De Stefani, A., Deantoni, C. L., Degli Esposti, C., Destito, A., Detti, B., Di Muzio, N., Di Stasio, A., Di Stefano, C., Di Trapani, D., Difino, G., Falivene, S., Farullo, G., Fedelini, P., Ferrari, I., Ferrau, F., Ferro, M., Fodor, A., Fontana, F., Francesca, F., Francolini, G., Frata, P., Frezza, G., Gabriele, P., Galeandro, M., Garibaldi, E., Gennari Pietro, G., Gentilucci, A., Giacobbe, A., Giussani, L., Giusti, G., Gontero, P., Guarneri, A., Guida, C., Gurioli, A., Huqi, D., Imbimbo, C., Ingrosso, G., Iotti, C., Italia, C., La Mattina, P., Lamanna, E., Lastrucci, L., Lazzari, G., Liberale, F., Liguori, G., Lisi, R., Lohr, F., Lombardo, R., Lovisolo, J. A. J., Ludovico Giuseppe, M., Macchione, N., Maggio, F., Malizia, M., Manasse, G., Mandoliti, G., Mantini, G., Marafioti, L., Marciello, L., Marconi Alberto, M., Martilotta, A., Marzano, S., Masciullo, S., Maso, G., Massenzo, A., Mazzeo, E., Mearini, L., Medoro, S., Mole, R., Monesi, G., Montanari, E., Montefiore, F., Montesi, G., Morgia, G., Moro, G., Muscas, G., Musio, D., Muto, P., Muzzonigro, G., Napodano, G., Negro, C. L. A., Nidini, M., Ntreta, M., Orsatti, M., Palazzolo, C., Palumbo, I., Parisi, A., Parma, P., Pavan, N., Pericolini, M., Pinto, F., Pistone, A., Pizzuti, V., Platania, A., Polli, C., Pomara, G., Ponti, E., Porcaro, A. B., Porpiglia, F., Pugliese, D., Pycha, A., Raguso, G., Rampini, A., Randone Donato, F., Roboldi, V., Roscigno, M., Ruggieri, M. P., Ruoppo, G., Sanseverino, R., Santacaterina, A., Santarsieri, M., Santoni, R., Scagliarini, S., Scagliotti Giorgio, V., Scanzi, M., Scarcia, M., Schiavina, R., Sciarra, A., Sciorio, C., Scolaro, T., Scuzzarella, S., Selvaggio, O., Serao, A., Serni, S., Signor, M. A., Silvani, M., Silvano, G., Silvestris, F., Simone, V., Spagnoletti, G., Spinelli Matteo, G., Squillace, L., Tombolini, V., Toninelli, M., Trinchieri, A., Trodella, L. E., Trodella, L., Trombetta, C., Tronnolone, L., Tucci, M., Urzi, D., Valdagni, R., Valeriani, M., Vanoli, M., Vitali, E., Volpe, A., Zaramella, S., Zeccolini, G., Zini, G., Antonelli, A, Palumbo, C, Noale, M, Porreca, A, Maggi, S, Simeone, C, Bassi, P, Bertoni, F, Bracarda, S, Buglione, M, Conti, G, Corvo, R, Gacci, M, Mirone, V, Montironi, R, Triggiani, L, Tubaro, A, Artibani, W, Crepaldi, G, Graziotti, P, Russi, E, Magrini Stefano, M, Muto, G, Pecoraro, S, Ricardi, U, Zagonel, V, Alitto Anna, R, Ambrosi, E, Aristei, C, Barbieri, M, Bardari, F, Bardoscia, L, Barra, S, Bartoncini, S, Basso, U, Becherini, C, Bellavita, R, Bergamaschi, F, Berlingheri, S, Berruti, A, Borghesi, M, Bortolus, R, Borzillo, V, Bosetti, D, Bove, G, Bove, P, Brausi, M, Bruni, A, Bruno, G, Brunocilla, E, Buffoli, A, Buttigliero, C, Cacciamani, G, Caldiroli, M, Cardo, G, Carmignani, G, Carrieri, G, Castelli, E, Castrezzati, E, Catalano, G, Cattarino, S, Catucci, F, Cavallini, F, Ceccarini, O, Celia, A, Chiancone, F, Chini, T, Cianci, C, Cisternino, A, Collura, D, Corbella, F, Corinti, M, Corsi, P, Cortese, F, Corti, L, de Cosimo, N, Cristiano, O, D'Angelillo, R, Da Pozzo, L, D'Agostino, D, D'Elia, C, Dandrea, M, De Angelis, M, De Angelis, P, De Cobelli, O, De Concilio, B, De Lisa, A, De Luca, S, De Stefani, A, Deantoni, C, Degli Esposti, C, Destito, A, Detti, B, Di Muzio, N, Di Stasio, A, Di Stefano, C, Di Trapani, D, Difino, G, Falivene, S, Farullo, G, Fedelini, P, Ferrari, I, Ferrau, F, Ferro, M, Fodor, A, Fontana, F, Francesca, F, Francolini, G, Frata, P, Frezza, G, Gabriele, P, Galeandro, M, Garibaldi, E, Gennari Pietro, G, Gentilucci, A, Giacobbe, A, Giussani, L, Giusti, G, Gontero, P, Guarneri, A, Guida, C, Gurioli, A, Huqi, D, Imbimbo, C, Ingrosso, G, Iotti, C, Italia, C, La Mattina, P, Lamanna, E, Lastrucci, L, Lazzari, G, Liberale, F, Liguori, G, Lisi, R, Lohr, F, Lombardo, R, Lovisolo, J, Ludovico Giuseppe, M, Macchione, N, Maggio, F, Malizia, M, Manasse, G, Mandoliti, G, Mantini, G, Marafioti, L, Marciello, L, Marconi Alberto, M, Martilotta, A, Marzano, S, Masciullo, S, Maso, G, Massenzo, A, Mazzeo, E, Mearini, L, Medoro, S, Mole, R, Monesi, G, Montanari, E, Montefiore, F, Montesi, G, Morgia, G, Moro, G, Muscas, G, Musio, D, Muto, P, Muzzonigro, G, Napodano, G, Negro, C, Nidini, M, Ntreta, M, Orsatti, M, Palazzolo, C, Palumbo, I, Parisi, A, Parma, P, Pavan, N, Pericolini, M, Pinto, F, Pistone, A, Pizzuti, V, Platania, A, Polli, C, Pomara, G, Ponti, E, Porcaro, A, Porpiglia, F, Pugliese, D, Pycha, A, Raguso, G, Rampini, A, Randone Donato, F, Roboldi, V, Roscigno, M, Ruggieri, M, Ruoppo, G, Sanseverino, R, Santacaterina, A, Santarsieri, M, Santoni, R, Scagliarini, S, Scagliotti Giorgio, V, Scanzi, M, Scarcia, M, Schiavina, R, Sciarra, A, Sciorio, C, Scolaro, T, Scuzzarella, S, Selvaggio, O, Serao, A, Serni, S, Signor, M, Silvani, M, Silvano, G, Silvestris, F, Simone, V, Spagnoletti, G, Spinelli Matteo, G, Squillace, L, Tombolini, V, Toninelli, M, Trinchieri, A, Trodella, L, Trombetta, C, Tronnolone, L, Tucci, M, Urzi, D, Valdagni, R, Valeriani, M, Vanoli, M, Vitali, E, Volpe, A, Zaramella, S, Zeccolini, G, and Zini, G
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Male ,Patient-reported outcome measures ,Prostate cancer ,Quality of life ,Radical prostatectomy ,Sexual function ,Urinary function ,Patient Reported Outcome Measure ,medicine.medical_treatment ,030232 urology & nephrology ,Longitudinal Studie ,Aged ,Data Collection ,Humans ,Italy ,Longitudinal Studies ,Middle Aged ,Patient Reported Outcome Measures ,Prospective Studies ,Prostate ,Prostatectomy ,Prostatic Neoplasms ,Quality of Life ,Retrospective Studies ,Robotic Surgical Procedures ,Surveys and Questionnaires ,Treatment Outcome ,Propensity Score ,0302 clinical medicine ,Retrospective Studie ,Medicine ,Surveys and Questionnaire ,Prospective cohort study ,Patient-reported outcome measure ,030220 oncology & carcinogenesis ,Human ,medicine.medical_specialty ,Robotic Surgical Procedure ,Urology ,03 medical and health sciences ,Clinical significance ,business.industry ,Retrospective cohort study ,Prospective Studie ,Propensity score matching ,Prostatic Neoplasm ,Observational study ,business - Abstract
Background: To report health-related quality of life outcomes as assessed by validated patient-reported outcome measures (PROMs) after radical prostatectomy (RP). Methods: This study analyzed patients treated with RP within The PROState cancer monitoring in Italy, from the National Research Council (Pros-IT CNR). Italian versions of Short-Form Heath Survey and university of California los Angeles-prostate cancer index questionnaires were administered. PROMs were physical composite scores, mental composite scores and urinary, bowel, sexual functions and bothers (UF/B, BF/B, SF/B). Baseline unbalances were controlled with propensity scores and stabilized inverse weights; differences in PROMs between different RP approaches were estimated by mixed models. Results: Of 541 patients treated with RP, 115 (21%) received open RP (ORP), 90 (17%) laparoscopic RP (LRP) and 336 (61%) robot-assisted RP (RARP). At head-to-head comparisons, RARP showed higher 12-month UF vs. LRP (interaction treatment * time p = 0.03) and 6-month SF vs. ORP (p < 0.001). At 12-month from surgery, 67, 73 and 79% of patients used no pad for urinary loss in ORP, LRP and RARP respectively (no differences for each comparison). Conversely, 16, 27 and 40% of patients declared erections firm enough for sexual intercourse in ORP, LRP and RARP respectively (only significant difference for ORP vs. RARP, p = 0.0004). Conclusions: Different RP approaches lead to significant variations in urinary and sexual PROMs, with a general trend in favour of RARP. However, their clinical significance seems limited.
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- 2019
242. Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients: The Pros-IT CNR study
- Author
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Angelo, Porreca, Marianna, Noale, Walter, Artibani, Pier Francesco Bassi, Filippo, Bertoni, Sergio, Bracarda, Giario Natale Conti, Renzo, Corvò, Mauro, Gacci, Pierpaolo, Graziotti, Magrini, STEFANO MARIA, Vincenzo, Mirone, Rodolfo, Montironi, Giovanni, Muto, Stefano, Pecoraro, Umberto, Ricardi, Elvio, Russi, Andrea, Tubaro, Vittorina, Zagonel, Gaetano, Crepaldi, Stefania, Maggi, Pierfrancesco, Bassi, Stefano Maria Magrini, Anna Rita Alitto, Enrica, Ambrosi, Alessandro, Antonelli, Cynthia, Aristei, Michele, Barbieri, Franco, Bardari, Lilia, Bardoscia, Salvina, Barra, Sara, Bartoncini, Umberto, Basso, Carlotta, Becherini, Rita, Bellavita, Franco, Bergamaschi, Stefania, Berlingheri, Berruti, Alfredo, Marco, Borghesi, Roberto, Bortolus, Valentina, Borzillo, Davide, Bosetti, Giuseppe, Bove, Pierluigi, Bove, Maurizio, Brausi, Alessio, Bruni, Giorgio, Bruno, Eugenio, Brunocilla, Alberto, Buffoli, BUGLIONE DI MONALE E BASTIA, Michela, Consuelo, Buttigliero, Giovanni, Cacciamani, Michela, Caldiroli, Giuseppe, Cardo, Giorgio, Carmignani, Giuseppe, Carrieri, Emanuele, Castelli, Elisabetta, Castrezzati, Gianpiero, Catalano, Susanna, Cattarino, Francesco, Catucci, Francolini Dario Cavallini, Ofelia, Ceccarini, Antonio, Celia, Francesco, Chiancone, Tommaso, Chini, Claudia, Cianci, Antonio, Cisternino, Devis, Collura, Franco, Corbella, Matteo, Corinti, Paolo, Corsi, Fiorenza, Cortese, Luigi, Corti, Cosimo de Nunzio, Olga, Cristiano, Rolando, M D'Angelillo, Luigi Da Pozzo, Daniele, D'Agostino, Carolina, D'Elia, Matteo, Dandrea, Michele De Angelis, Paolo De Angelis, Ottavio De Cobelli, Bernardino De Concilio, Antonello De Lisa, Stefano De Luca, Agostina De Stefani, Chiara Lucrezia Deantoni, Esposti Claudio Degli, Anna, Destito, Beatrice, Detti, Nadia Di Muzio, Andrea Di Stasio, Calogero Di Stefano, Danilo Di Trapani, Giuseppe, Difino, Sara, Falivene, Giuseppe, Farullo, Paolo, Fedelini, Ilaria, Ferrari, Francesco, Ferrau, Matteo, Ferro, Andrei, Fodor, Francesco, Fontanta, Francesco, Francesca, Giulio, Francolini, Paolo, Frata, Giovanni, Frezza, Pietro, Gabriele, Maria, Galeandro, Elisabetta, Garibaldi, Pietro Giovanni Gennari, Alessandro, Gentilucci, Alessandro, Giacobbe, Laura, Giussani, Giuseppe, Giusti, Paolo, Gontero, Alessia, Guarneri, Cesare, Guida, Alberto, Gurioli, Dorijan, Huqi, Ciro, Imbimbo, Gianluca, Ingrosso, Cinzia, Iotti, Corrado, Italia, Pierdaniele La Mattina, Enza, Lamanna, Luciana, Lastrucci, Grazia, Lazzari, Fabiola, Liberale, Giovanni, Liguori, Roberto, Lisi, Frank, Lohr, Riccardo, Lombardo, Jon A, J Lovisolo, Giuseppe Mario Ludovico, Nicola, Macchione, Francesca, Maggio, Michele, Malizia, Gianluca, Manasse, Giovanni, Mandoliti, Giovanna, Mantini, Luigi, Marafioti, Luisa, Marciello, Alberto Mario Marconi, Antonietta, Martilotta, Salvino, Marzano, Stefano, Masciullo, Gloria, Maso, Adele, Massenzo, Ercole, Mazzeo, Luigi, Mearini, Serena, Medoro, Rosa, Molè, Giorgio, Monesi, Emanuele, Montanari, Franco, Montefiore, Giampaolo, Montesi, Giuseppe, Morgia, Gregorio, Moro, Giorgio, Muscas, Daniela, Musio, Paolo, Muto, Giovanni, Muzzonigro, Giorgio, Napodano, Carlo Luigi Augusto Negro, Mattia, Nidini, Maria, Ntreta, Marco, Orsatti, Carmela, Palazzolo, Isabella, Palumbo, Alessandro, Parisi, Paolo, Parma, Nicola, Pavan, Martina, Pericolini, Francesco, Pinto, Antonio, Pistone, Valerio, Pizzuti, Angelo, Platania, Caterina, Polli, Giorgio, Pomara, Elisabetta, Ponti, Antonio Benito Porcaro, Francesco, Porpiglia, Dario, Pugliese, Armin, Pycha, Giuseppe, Raguso, Andrea, Rampini, Donato Franco Randone, Valentina, Roboldi, Marco, Roscigno, Maria Paola Ruggieri, Giuseppe, Ruoppo, Roberto, Sanseverino, Anna, Santacaterina, Michele, Santarsieri, Riccardo, Santoni, Sarah, Scagliarini, Giorgio Vittorio Scagliotti, Mauro, Scanzi, Marcello, Scarcia, Riccardo, Schiavina, Alessandro, Sciarra, Carmine, Sciorio, Tindaro, Scolaro, Salvatore, Scuzzarella, Oscar, Selvaggio, Armando, Serao, Sergio, Serni, Marco Andrea Signor, Mauro, Silvani, Giovanni, Silvano, Franco, Silvestris, Simeone, Claudio, Valeria, Simone, Girolamo, Spagnoletti, Matteo Giulio Spinelli, Luigi, Squillace, Vincenzo, Tombolini, Mariastella, Toninelli, Triggiani, Luca, Alberto, Trinchieri, Luca Eolo Trodella, Lucio, Trodella, Carlo, Trombetta, Lidia, Tronnolone, Marcello, Tucci, Daniele, Urzì, Riccardo, Valdagni, Maurizio, Valeriani, Maurizio, Vanoli, Elisabetta, Vitali, Alessandro, Volpe, Stefano, Zaramella, Guglielmo, Zeccolini, Giampaolo, Zini, Porreca, Angelo, Noale, Marianna, Artibani, Walter, Bassi, Pier Francesco, Bertoni, Filippo, Bracarda, Sergio, Conti, Giario Natale, Corvò, Renzo, Gacci, Mauro, Graziotti, Pierpaolo, Magrini, Stefano Maria, Mirone, Vincenzo, Montironi, Rodolfo, Muto, Giovanni, Pecoraro, Stefano, Ricardi, Umberto, Russi, Elvio, Tubaro, Andrea, Zagonel, Vittorina, Crepaldi, Gaetano, Maggi, Stefania, Gaetano, Crepaldi, Umberto, Basso, Luigi, Corti, D'Agostino, Daniele, Matteo, Dandrea, Davide, Bosetti, Gianpiero, Catalano, Ottavio, De Cobelli, Lucrezia, Deantoni Chiara, Nadia, Di Muzio, Ferro, Matteo, Andrei, Fodor, Pierdaniele, La Mattina, Emanuele, Montanari, Barbieri, Michele, Valentina, Borzillo, Chiancone, Francesco, Sara, Falivene, Paolo, Fedelini, Imbimbo, Ciro, Paolo, Muto, Sarah, Scagliarini, Giovanni, Muzzonigro, Enrica, Ambrosi, Alessandro, Antonelli, Lilia, Bardoscia, Stefania, Berlingheri, Alfredo, Berruti, Alberto, Buffoli, Michela, Buglione, Mauro, Scanzi, Elisabetta, Castrezzati, Paolo, Frata, Giulio, Francolini, Beatrice, Detti, Tommaso, Chini, Carlotta, Becherini, Olga, Cristiano, Cesare, Guida, Sara, Bartoncini, Consuelo, Buttigliero, Emanuele, Castelli, Devis, Collura, Stefano, De Luca, Pietro, Gabriele, Elisabetta, Garibaldi, Alessandro, Giacobbe, Paolo, Gontero, Alessia, Guarneri, Alberto, Gurioli, Francesco, Porpiglia, Franco, Randone Donato, Vittorio, Scagliotti Giorgio, Cynthia, Aristei, Rita, Bellavita, Isabella, Palumbo, Franco, Bardari, Augusto, Negro Carlo Luigi, Franco, Bergamaschi, Maria, Galeandro, Cinzia, Iotti, Giuseppe, Raguso, Paola, Ruggieri Maria, Giuseppe, Ruoppo, Marco, Borghesi, Eugenio, Brunocilla, Claudio, Degli Esposti, Giovanni, Frezza, Michele, Malizia, Maria, Ntreta, Alessandro, Parisi, Riccardo, Schiavina, Roberto, Bortolu, Giuseppe, Bove, Antonio, Cisternino, Carrieri, Giuseppe, Giuseppe, Difino, Oscar, Selvaggio, Maurizio, Brausi, Alessio, Bruni, Frank, Lohr, Ercole, Mazzeo, Enza, Lamanna, Calogero, Di Stefano, Giorgio, Bruno, Michela, Caldiroli, Ilaria, Ferrari, Laura, Giussani, Lovisolo Jon, A. J., Mario, Marconi Alberto, Giuseppe, Cardo, Mario, Ludovico Giuseppe, Marcello, Scarcia, Giorgio, Carmignani, Salvina, Barra, Dario, Cavallini Francolini, Franco, Corbella, Ofelia, Ceccarini, Luigi, Da Pozzo, Agostina, De Stefani, Corrado, Italia, Stefano, Masciullo, Valentina, Roboldi, Marco, Roscigno, Antonio, Celia, Bernardino, De Concilio, Claudia, Cianci, Francesco, Francesca, Giorgio, Pomara, Michele, Santarsieri, Fiorenza, Cortese, Andrea, Di Stasio, Franco, Montefiore, Armando, Serao, D'Elia, Carolina, Armin, Pycha, Dorijan, Huqi, Paolo, De Angeli, Nicola, Macchione, Francesco, Fontanta, Giorgio, Monesi, Antonello, De Lisa, Giuseppe, Giusti, Giorgio, Musca, Anna, Destito, Rosa, Molè, Danilo, Di Trapani, Francesco, Ferrau, Carmela, Palazzolo, Angelo, Platania, Anna, Santacaterina, Grazia, Lazzari, Fabiola, Liberale, Gregorio, Moro, Giovanni, Liguori, Nicola, Pavan, Francesca, Maggio, Marco, Orsatti, Giovanni, Mandoliti, Giampaolo, Montesi, Luigi, Marafioti, Antonietta, Martilotta, Adele, Massenzo, Luisa, Marciello, Salvino, Marzano, Caterina, Polli, Gloria, Maso, Serena, Medoro, Giuseppe, Morgia, Napodano, Giorgio, Pistone, Antonio, Roberto, Sanseverino, Mattia, Nidini, Paolo, Parma, Valerio, Pizzuti, Sciorio, Carmine, Scuzzarella, Salvatore, Tindaro, Scolaro, Porreca A, Noale M, Artibani W, Bassi PF, Bertoni F, Bracarda S, Conti GN, Corvò R, Gacci M, Graziotti P, Magrini SM, Mirone V, Montironi R, Muto G, Pecoraro S, Ricardi U, Russi E, Tubaro A, Zagonel V, Crepaldi G, Maggi S, Crepaldi G, Maggi S, Noale M, Porreca A, Artibani W, Bassi P, Bracarda S, Conti GN, Corvò R, Graziotti P, Russi E, Mirone V, Montironi R, Bertoni F, Gacci M, Magrini SM, Muto G, Pecoraro S, Ricardi U, Tubaro A, Zagonel V, Alitto AR, Ambrosi E, Antonelli A, Aristei C, Barbieri M, Bardari F, Bardoscia L, Barra S, Bartoncini S, Basso U, Becherini C, Bellavita R, Bergamaschi F, Berlingheri S, Berruti A, Borghesi M, Bortolus R, Borzillo V, Bosetti D, Bove G, Bove P, Brausi M, Bruni A, Bruno G, Brunocilla E, Buffoli A, Buglione M, Buttigliero C, Cacciamani G, Caldiroli M, Cardo G, Carmignani G, Carrieri G, Castelli E, Castrezzati E, Catalano G, Cattarino S, Catucci F, Cavallini FD, Ceccarini O, Celia A, Chiancone F, Chini T, Cianci C, Cisternino A, Collura D, Corbella F, Corinti M, Corsi P, Cortese F, Corti L, de Nunzio C, Cristiano O, D'Angelillo RM, Da Pozzo L, D'agostino D, D'Elia C, Dandrea M, De Angelis M, De Angelis P, De Cobelli O, De Concilio B, De Lisa A, De Luca S, De Stefani A, Deantoni CL, Degli EC, Destito A, Detti B, Di Muzio N, Di Stasio A, Di Stefano C, Di Trapani D, Difino G, Falivene S, Farullo G, Fedelini P, Ferrari I, Ferrau F, Ferro M, Fodor A, Fontanta F, Francesca F, Francolini G, Frata P, Frezza G, Gabriele P, Galeandro M, Garibaldi E, Gennari PG, Gentilucci A, Giacobbe A, Giussani L, Giusti G, Gontero P, Guarneri A, Guida C, Gurioli A, Huqi D, Imbimbo C, Ingrosso G, Iotti C, Italia C, La Mattina P, Lamanna E, Lastrucci L, Lazzari G, Liberale F, Liguori G, Lisi R, Lohr F, Lombardo R, Lovisolo JAJ, Ludovico GM, Macchione N, Maggio F, Malizia M, Manasse G, Mandoliti G, Mantini G, Marafioti L, Marciello L, Marconi AM, Martilotta A, Marzano S, Masciullo S, Maso G, Massenzo A, Mazzeo E, Mearini L, Medoro S, Molè R, Monesi G, Montanari E, Montefiore F, Montesi G, Morgia G, Moro G, Muscas G, Musio D, Muto P, Muzzonigro G, Napodano G, Negro CLA, Nidini M, Ntreta M, Orsatti M, Palazzolo C, Palumbo I, Parisi A, Parma P, Pavan N, Pericolini M, Pinto F, Pistone A, Pizzuti V, Platania A, Polli C, Pomara G, Ponti E, Porcaro AB, Porpiglia F, Pugliese D, Pycha A, Raguso G, Rampini A, Randone DF, Roboldi V, Roscigno M, Ruggieri MP, Ruoppo G, Sanseverino R, Santacaterina A, Santarsieri M, Santoni R, Scagliarini S, Scagliotti GV, Scanzi M, Scarcia M, Schiavina R, Sciarra A, Sciorio C, Scolaro T, Scuzzarella S, Selvaggio O, Serao A, Serni S, Signor MA, Silvani M, Silvano G, Silvestris F, Simeone C, Simone V, Spagnoletti G, Spinelli MG, Squillace L, Tombolini V, Toninelli M, Triggiani L, Trinchieri A, Trodella LE, Trodella L, Trombetta C, Tronnolone L, Tucci M, Urzì D, Valdagni R, Valeriani M, Vanoli M, Vitali E, Volpe A, Zaramella S, Zeccolini G, Zini G, Porreca, A., Noale, M., Artibani, W., Bassi, P. F., Bertoni, F., Bracarda, S., Conti, G. N., Corvo, R., Gacci, M., Graziotti, P., Magrini, S. M., Mirone, V., Montironi, R., Muto, G., Pecoraro, S., Ricardi, U., Russi, E., Tubaro, A., Zagonel, V., Crepaldi, G., Maggi, S., Alitto, A. R., Ambrosi, E., Antonelli, A., Aristei, C., Barbieri, M., Bardari, F., Bardoscia, L., Barra, S., Bartoncini, S., Basso, U., Becherini, C., Bellavita, R., Bergamaschi, F., Berlingheri, S., Berruti, A., Borghesi, M., Bortolus, R., Borzillo, V., Bosetti, D., Bove, G., Bove, P., Maurizio, B., Alessio, B., Giorgio, B., Eugenio, B., Alberto, B., Michela, B., Consuelo, B., Giovanni, C., Michela, C., Giuseppe, C., Giorgio, C., Emanuele, C., Elisabetta, C., Gianpiero, C., Susanna, C., Catucci, F., Dario, C. F., Ofelia, C., Antonio, C., Francesco, C., Tommaso, C., Claudia, C., Devis, C., Franco, C., Matteo, C., Paolo, C., Fiorenza, C., Luigi, C., Cosimo, N., Cristiano, O., D'Angelillo, R. M., Da Pozzo, L., D'Agostino, D., D'Elia, C., Dandrea, M., De Angelis, M., De Angelis, P., De Cobelli, O., De Concilio, B., De Lisa, A., De Luca, S., De Stefani, A., Deantoni, C. L., Degli, E. C., Destito, A., Detti, B., Di Muzio, N., Di Stasio, A., Di Stefano, C., Di Trapani, D., Difino, G., Falivene, S., Farullo, G., Fedelini, P., Ferrari, I., Ferrau, F., Ferro, M., Fodor, A., Fontanta, F., Francesca, F., Francolini, G., Frata, P., Frezza, G., Gabriele, P., Galeandro, M., Garibaldi, E., Gennari, P. G., Gentilucci, A., Giacobbe, A., Giussani, L., Giusti, G., Gontero, P., Guarneri, A., Guida, C., Gurioli, A., Huqi, D., Imbimbo, C., Ingrosso, G., Iotti, C., Italia, C., La Mattina, P., Lamanna, E., Lastrucci, L., Lazzari, G., Liberale, F., Liguori, G., Lisi, R., Lohr, F., Lombardo, R., Lovisolo, J. A. J., Ludovico, G. M., Macchione, N., Maggio, F., Malizia, M., Manasse, G., Mandoliti, G., Mantini, G., Marafioti, L., Marciello, L., Marconi, A. M., Martilotta, A., Marzano, S., Masciullo, S., Maso, G., Massenzo, A., Mazzeo, E., Mearini, L., Medoro, S., Mole, R., Monesi, G., Montanari, E., Montefiore, F., Montesi, G., Morgia, G., Moro, G., Muscas, G., Musio, D., Muto, P., Muzzonigro, G., Napodano, G., Negro, C. L. A., Nidini, M., Ntreta, M., Orsatti, M., Palazzolo, C., Palumbo, I., Parisi, A., Parma, P., Pavan, N., Pericolini, M., Pinto, F., Pistone, A., Pizzuti, V., Platania, A., Polli, C., Pomara, G., Ponti, E., Porcaro, A. B., Porpiglia, F., Pugliese, D., Pycha, A., Raguso, G., Rampini, A., Randone, D. F., Roboldi, V., Roscigno, M., Ruggieri, M. P., Ruoppo, G., Sanseverino, R., Santacaterina, A., Santarsieri, M., Santoni, R., Scagliarini, S., Scagliotti, G. V., Scanzi, M., Scarcia, M., Schiavina, R., Sciarra, A., Sciorio, C., Scolaro, T., Scuzzarella, S., Selvaggio, O., Serao, A., Serni, S., Signor, M. A., Silvani, M., Silvano, G., Silvestris, F., Simeone, C., Simone, V., Spagnoletti, G., Spinelli, M. G., Squillace, L., Tombolini, V., Toninelli, M., Triggiani, L., Trinchieri, A., Trodella, L. E., Trodella, L., Trombetta, C., Tronnolone, L., Tucci, M., Urzi, D., Valdagni, R., Valeriani, M., Vanoli, M., Vitali, E., Volpe, A., Zaramella, S., Zeccolini, G., Zini, G., Porreca, A, Noale, M, Artibani, W, Bassi, P, Bertoni, F, Bracarda, S, Conti, G, Corvò, R, Gacci, M, Graziotti, P, Magrini, S, Mirone, V, Montironi, R, Muto, G, Pecoraro, S, Ricardi, U, Russi, E, Tubaro, A, Zagonel, V, Crepaldi, G, Maggi, S, and Da Pozzo, L
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Male ,030232 urology & nephrology ,Severity of Illness Index ,Prostate cancer ,0302 clinical medicine ,Quality of life ,Activities of Daily Living ,Diagnosis ,Medicine ,Age Factor ,Prospective Studies ,Prospective cohort study ,Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA ,Age Factors ,Pros-IT CNR study ,General Medicine ,Health Survey ,Middle Aged ,Neoadjuvant Therapy ,3. Good health ,Italy ,030220 oncology & carcinogenesis ,lcsh:R858-859.7 ,Regression Analysis ,Public Health ,Human ,Diagnosi ,prostate cancer, survival, quality of life ,medicine.medical_specialty ,lcsh:Computer applications to medicine. Medical informatics ,Regression Analysi ,03 medical and health sciences ,Percutaneous Coronary Intervention ,Internal medicine ,Severity of illness ,Humans ,Aged ,Cancer staging ,business.industry ,Research ,Environmental and Occupational Health ,Public Health, Environmental and Occupational Health ,Prostatic Neoplasms ,Cancer ,medicine.disease ,Health Surveys ,Comorbidity ,Quality of Life ,Prospective Studie ,Settore MED/24 ,Prostatic Neoplasm ,business ,Sexual function - Abstract
Background The National Research Council (CNR) prostate cancer monitoring project in Italy (Pros-IT CNR) is an observational, prospective, ongoing, multicentre study aiming to monitor a sample of Italian males diagnosed as new cases of prostate cancer. The present study aims to present data on the quality of life at time prostate cancer is diagnosed. Methods One thousand seven hundred five patients were enrolled. Quality of life is evaluated at the time cancer was diagnosed and at subsequent assessments via the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and the Short Form Health Survey (SF-12). Results At diagnosis, lower scores on the physical component of the SF-12 were associated to older ages, obesity and the presence of 3+ moderate/severe comorbidities. Lower scores on the mental component were associated to younger ages, the presence of 3+ moderate/severe comorbidities and a T-score higher than one. Urinary and bowel functions according to UCLA-PCI were generally good. Almost 5% of the sample reported using at least one safety pad daily to control urinary loss; less than 3% reported moderate/severe problems attributable to bowel functions, and sexual function was a moderate/severe problem for 26.7%. Diabetes, 3+ moderate/severe comorbidities, T2 or T3-T4 categories and a Gleason score of eight or more were significantly associated with lower sexual function scores at diagnosis. Conclusions Data collected by the Pros-IT CNR study have clarified the baseline status of newly diagnosed prostate cancer patients. A comprehensive assessment of quality of life will allow to objectively evaluate outcomes of different profile of care.
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- 2018
243. Radiomics in PI-RADS 3 Multiparametric MRI for Prostate Cancer Identification: Literature Models Re-Implementation and Proposal of a Clinical–Radiological Model
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Andrea Corsi, Elisabetta De Bernardi, Pietro Andrea Bonaffini, Paolo Niccolò Franco, Dario Nicoletta, Roberto Simonini, Davide Ippolito, Giovanna Perugini, Mariaelena Occhipinti, Luigi Filippo Da Pozzo, Marco Roscigno, Sandro Sironi, Corsi, A, De Bernardi, E, Bonaffini, P, Franco, P, Nicoletta, D, Simonini, R, Ippolito, D, Perugini, G, Occhipinti, M, Da Pozzo, L, Roscigno, M, and Sironi, S
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radiomic ,texture analysi ,PI-RADS 3 ,prostate cancer ,MRI ,radiomics ,texture analysis ,General Medicine - Abstract
PI-RADS 3 prostate lesions clinical management is still debated, with high variability among different centers. Identifying clinically significant tumors among PI-RADS 3 is crucial. Radiomics applied to multiparametric MR (mpMR) seems promising. Nevertheless, reproducibility assessment by external validation is required. We retrospectively included all patients with at least one PI-RADS 3 lesion (PI-RADS v2.1) detected on a 3T prostate MRI scan at our Institution (June 2016–March 2021). An MRI-targeted biopsy was used as ground truth. We assessed reproducible mpMRI radiomic features found in the literature. Then, we proposed a new model combining PSA density and two radiomic features (texture regularity (T2) and size zone heterogeneity (ADC)). All models were trained/assessed through 100-repetitions 5-fold cross-validation. Eighty patients were included (26 with GS ≥ 7). In total, 9/20 T2 features (Hector’s model) and 1 T2 feature (Jin’s model) significantly correlated to biopsy on our dataset. PSA density alone predicted clinically significant tumors (sensitivity: 66%; specificity: 71%). Our model obtained a sensitivity of 80% and a specificity of 76%. Standard-compliant works with detailed methodologies achieve comparable radiomic feature sets. Therefore, efforts to facilitate reproducibility are needed, while complex models and imaging protocols seem not, since our model combining PSA density and two radiomic features from routinely performed sequences appeared to differentiate clinically significant cancers.
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- 2022
244. A Nomogram for the Prediction of Intermediate Significant Renal Function Loss After Robot-assisted Partial Nephrectomy for Localized Renal Tumors: A Prospective Multicenter Observational Study (RECORd2 Project)
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Alessandro Antonelli, Andrea Minervini, Roberto Bertini, Marco Roscigno, Paolo Gontero, Eugenio Brunocilla, Francesco Porpiglia, Enrico Checcucci, Marco Carini, Salvatore Siracusano, Cristian Fiori, Andrea Mari, Daniele Amparore, Nicola Longo, Riccardo Tellini, Claudio Simeone, Maria Furlan, Vincenzo Ficarra, Luigi F. Da Pozzo, Fabrizio Di Maida, Umberto Capitanio, Riccardo Schiavina, Mari A., Tellini R., Antonelli A., Porpiglia F., Schiavina R., Amparore D., Bertini R., Brunocilla E., Capitanio U., Checcucci E., Da Pozzo L., Di Maida F., Fiori C., Furlan M., Gontero P., Longo N., Roscigno M., Simeone C., Siracusano S., Ficarra V., Carini M., and Minervini A.
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Male ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,Renal function ,Nephron-sparing surgery ,Logistic regression ,Kidney ,Nephrectomy ,Robotic Surgical Procedures ,Ischemia ,Interquartile range ,Renal cell carcinoma ,Chronic kidney disease ,Diabetes mellitus ,medicine ,Partial nephrectomy ,Humans ,Prospective Studies ,Vascular disease ,business.industry ,Robotics ,Functional outcome ,Nomogram ,medicine.disease ,Kidney Neoplasms ,Nomograms ,Treatment Outcome ,Female ,business - Abstract
Background: Robot-assisted partial nephrectomy (RAPN) is increasingly adopted for the treatment of localized renal tumors; however, rates and predictors of significant renal function (RF) loss after RAPN are still poorly investigated, especially at a long-term evaluation. Objective: To analyze the predictive factors and develop a clinical nomogram for predicting the likelihood of ultimate RF loss after RAPN. Design, setting, and participants: We prospectively evaluated all patients treated with RAPN in a multicenter series (RECORd2 project). Outcome measurements and statistical analysis: Significant RF loss was defined as >25% reduction in estimated glomerular filtration rate (eGFR) from preoperative assessment at 48th month follow-up after surgery. Uni- and multivariable logistic regression analyses for RF loss were performed. The area under the receiving operator characteristic curve (AUC) was used to quantify predictive discrimination. A nomogram was created from the multivariable model. Results and limitations: A total of 981 patients were included. The median age at surgery was 64.2 (interquartile range [IQR] 54.3–71.4) yr, and 62.4% of patients were male. The median Charlson Comorbidity Index (CCI) was 1 (IQR 0–2), 12.9% of patients suffered from diabetes mellitus, and 18.6% of patients showed peripheral vascular disease (PVD). The median Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) score was 7 (IQR 7–9). Imperative indications to partial nephrectomy were present in 3.6% of patients. Significant RF loss at 48th month postoperative evaluation was registered in 108 (11%) patients. At multivariable analysis, age (p = 0.04), female gender (p < 0.0001), CCI (p < 0.0001), CCI (p < 0.0001), diabetes (p < 0.0001), PVD (p < 0.0001), eGFR (p = 0.02), imperative (p = 0.001) surgical indication, and PADUA score (p < 0.0001) were found to be predictors of RF loss. The developed nomogram including these variables showed an AUC of 0.816. Conclusions: We developed a clinical nomogram for the prediction of late RF loss after RAPN using preoperative and surgical variables from a large multicenter dataset. Patient summary: We developed a nomogram that could represent a clinical tool for early detection of patients at the highest risk of significant renal function impairment after robotic conservative surgery for renal tumors.
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- 2021
245. Does the Unexpected Presence of Non-organ-confined Disease at Final Pathology Undermine Cancer Control in Patients with Clinical T1N0M0 Renal Cell Carcinoma Who Underwent Partial Nephrectomy?
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Idir Ouzaid, Paolo Dell'Oglio, Andrea Minervini, James Lingard, Maciej Salagierski, Grant D. Stewart, Sabine Brookman-May, Maria Carmen Mir, Marco Carini, Oscar Rodriguez Faba, Bulent Akdogan, Francesco Montorsi, Marco Roscigno, Luigi F. Da Pozzo, Tobias Klatte, Emanuele Zaffuto, Christian G. Stief, Martin Marszalek, Umberto Capitanio, Capitanio, Umberto, Stewart, Grant D., Klatte, Tobia, Akdogan, Bulent, Roscigno, Marco, Marszalek, Martin, Dell'Oglio, Paolo, Zaffuto, Emanuele, Rodriguez Faba, Oscar, Salagierski, Maciej, Lingard, Jame, Carini, Marco, Ouzaid, Idir, Mir, Maria Carmen, Montorsi, Francesco, Da Pozzo, Luigi Filippo, Stief, Christian, Minervini, Andrea, Brookman-May, Sabine D., Stewart, Grant [0000-0003-3188-9140], Apollo - University of Cambridge Repository, Capitanio, U, Stewart, G, Klatte, T, Akdogan, B, Roscigno, M, Marszalek, M, Dell'Oglio, P, Zaffuto, E, Rodriguez Faba, O, Salagierski, M, Lingard, J, Carini, M, Ouzaid, I, Mir, M, Montorsi, F, Da Pozzo, L, Stief, C, Minervini, A, and Brookman-May, S
- Subjects
Male ,Pathology ,medicine.medical_treatment ,030232 urology & nephrology ,Kaplan-Meier Estimate ,Disease ,Nephrectomy ,0302 clinical medicine ,Retrospective Studie ,cancer control ,Renal cell carcinoma ,Partial nephrectomy ,Medicine ,Neoplasm Metastasis ,Multivariate Analysi ,Upstaging ,Kidney ,Cancer control ,Kidney cancer ,Radical nephrectomy ,Renal cancer ,Kidney Neoplasm ,kidney cancer ,Middle Aged ,Kidney Neoplasms ,Neoplasm Metastasi ,Treatment Outcome ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Disease Progression ,Female ,Human ,radical nephrectomy ,medicine.medical_specialty ,partial nephrectomy ,Urology ,renal cancer ,03 medical and health sciences ,Humans ,Propensity Score ,Carcinoma, Renal Cell ,Proportional Hazards Models ,Retrospective Studies ,Aged ,Neoplasm Staging ,business.industry ,Proportional hazards model ,Retrospective cohort study ,medicine.disease ,upstaging ,Multivariate Analysis ,Propensity score matching ,Proportional Hazards Model ,business - Abstract
Background: A non-negligible proportion of individuals diagnosed with cT1 renal cell carcinoma (RCC) are upstaged to pT3a at final pathology. Few data on oncological outcomes for these patients are available to determine whether partial nephrectomy (PN) might jeopardise cancer control. Objective: To assess, within an international multi-institutional collaboration, whether PN might undermine cancer control relative to radical nephrectomy (RN) in RCC patients with unexpected pT3a disease. Design, setting, and participants: International multi-institutional collaboration including patients with cT1abN0M0-pT3a RCC. Intervention: PN or RN. Outcome measurements and statistical analysis: We used Kaplan-Meier analyses, before and after propensity-score matching, to evaluate differences in metastatic progression (MP) and cancer-specific mortality (CSM) rates during follow-up. Univariable and multivariable Cox regression analyses were used to assess predictors of MP and CSM. Results and limitations: Overall, 309 patients with cT1abN0M0 RCC (cT1aN0M0, n = 107, 34.6%; cT1bN0M0, n = 202, 65.4%) had pT3a disease according to final pathology. Patients were treated with either PN (n = 71, 23%) or RN (n = 238, 77%). MP at 1, 2, and 5 yr was detected in 9.1%, 13.3%, and 24.1% of patients, respectively. CSM was 3.5%, 10.7%, and 18.4% at 1, 2, and 5 yr, respectively. After matching, no difference in terms of MP or CSM was observed between the PN and RN cohorts (both p>0.3). On multivariable analysis, type of surgery (PN vs RN) was not an independent predictor of either MP (p = 0.3) or CSM (p = 0.4). Limitations include the retrospective design. Conclusions: In patients with unexpected pT3a RCC at final pathology, PN does not appear to jeopardise cancer control with regard to MP and CSM. Patient summary: Cancer control is similar between patients treated with removal of the entire kidney and those with only partial removal, even if the final histology examination demonstrates a tumour that is unexpectedly not confined within the kidney. Partial nephrectomy does not undermine cancer control when unexpected pT3a renal cancer is identified at final pathology.
- Published
- 2018
246. Increased Use of Blood Transfusions to Manage Urological Conditions during the COVID-19 Pandemic
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Piercarlo Rossi, Cristian Guarasci, Luigi F. Da Pozzo, Marco Roscigno, Andrea Salonia, Luca Santoleri, Rosa Chianese, Fabio Muttin, P. Capogrosso, Giulio Carcano, M. Tassara, Richard Naspro, Luigi Candela, Federico Dehò, Francesco Montorsi, Capogrosso, P., Candela, L., Rossi, P., Guarasci, C., Muttin, F., Roscigno, M., Chianese, R., Santoleri, L., Tassara, M., Carcano, G., Naspro, R., Da Pozzo, L., Montorsi, F., Salonia, A., and Deho, F.
- Subjects
Urologic Diseases ,Transfusion rate ,medicine.medical_specialty ,Blood transfusion ,Coronavirus disease 2019 (COVID-19) ,Bleeding ,COVID-19 ,Hematuria ,Blood Transfusion ,Comorbidity ,Coronavirus Infections ,Humans ,Pandemics ,Pneumonia, Viral ,SARS-CoV-2 ,Betacoronavirus ,Urology ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,medicine.medical_treatment ,Delayed diagnosis ,Pandemic ,medicine ,Viral ,Original Paper ,business.industry ,Pneumonia ,medicine.disease ,Emergency medicine ,Urologic disease ,business - Abstract
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to an extensive reorganization of the healthcare system in Italy, with significant deferment of the treatment of urology patients. We aimed to assess the impact of deferred treatment during the SARS-CoV-2 pandemic on the need for blood transfusions in 3 Italian urology departments. Methods: We reviewed hospital chart data on blood transfusions at the urology units of 3 academic centers in the north of Italy from March to April 2020. Data were compared with values from the same time frame in 2019 (March to April 2019). Results: We observed significant reductions of the number of patients admitted to the urology units from March to April 2020 (373 vs. 119) and the number of performed surgeries (242 vs. 938) compared to 2019. Though, the number of transfused blood units was comparable between the 2 years (182 vs. 252), we found a greater mean number of blood units transfused per admission in 2020 (0.49 vs. 0.22; p < 0.0001). As a whole, the transfusion rate for hematuria was higher in 2020 than in 2019 (36 vs. 7.9%; p < 0.0001). Discussion/Conclusion: The observed increased number of blood transfusions needed throughout the SARS-CoV-2 era could have had a negative impact on both patients and the healthcare system. It is possible to speculate that this is the consequence of a delayed diagnosis and deferred treatment of acute conditions.
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- 2020
247. Diagnostic accuracy of multiparametric magnetic resonance imaging combined with clinical parameters in the detection of clinically significant prostate cancer: A novel diagnostic model
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Sandro Sironi, Luigi F. Da Pozzo, Giovanna Perugini, Giulia Querques, Davide Ippolito, Cesare Maino, Marco Roscigno, Anna Pecorelli, Ippolito, D, Querques, G, Pecorelli, A, Perugini, G, Roscigno, M, Da Pozzo, L, Maino, C, and Sironi, S
- Subjects
Image-Guided Biopsy ,Male ,Prostate Imaging Reporting and Data System ,medicine.medical_specialty ,Multivariate analysis ,Urology ,030232 urology & nephrology ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Prostate ,Biopsy ,medicine ,transrectal ultrasound ,Humans ,biopsy ,Multiparametric Magnetic Resonance Imaging ,Aged ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Prostatic Neoplasms ,Magnetic resonance imaging ,medicine.disease ,multiparametric magnetic resonance imaging ,prostate cancer ,Magnetic Resonance Imaging ,Confidence interval ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Radiology ,business - Abstract
Objectives: To evaluate the diagnostic accuracy of multiparametric magnetic resonance imaging in the detection of prostate cancer, according to Prostate Imaging Reporting and Data System, and the usefulness of combining clinical parameters to improve patients’ risk assessment. Methods: Overall, 201 patients underwent multiparametric magnetic resonance imaging investigation with a 3-T magnet and a 32-channel body coil based on triplanar high-resolution T2-weighted, diffusion-weighted and T1-weighted dynamic contrast-enhanced imaging before, during and after intravenous administration of paramagnetic contrast agent. Random transrectal ultrasound-guided biopsy was carried out for all eligible patients. If a Prostate Imaging Reporting and Data System ≥3 lesion was present, a targeted biopsy with magnetic resonance imaging-transrectal ultrasound fusion-guided system was carried out. Results: Sensitivity, specificity, positive predictive value and negative predictive value of Prostate Imaging Reporting and Data System ≥3 lesions for the detection of prostate cancer were 65.1%, 54.9%, 43.1% and 75.0% respectively, with an accuracy of 64.2% (55.1–72.7%). At uni- and multivariate analysis, age ≥70years and prostate-specific antigen density ≥0.15ng/mL/mL were significantly associated with prostate cancer. A new risk model named “modified Prostate Imaging Reporting and Data System” was created considering age and prostate-specific antigen density in addition to the Prostate Imaging Reporting and Data System score showing an improved correlation with prostate cancer compared with the Prostate Imaging Reporting and Data System alone (area under curve 71.4%, 95% confidence interval 62.2–80.5 vs area under curve 62.6%, 95% confidence interval 52.1–73; P≤0.0001). Conclusions: The accuracy of Prostate Imaging Reporting and Data System alone in the diagnosis of prostate cancer might be suboptimal, whereas a novel risk model based on the combination of multiparametric magnetic resonance imaging data with clinical parameters could offer higher discrimination and improve the ability of diagnosing clinically significant disease.
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- 2020
248. Concomitant carcinoma in situ is a feature of aggressive disease in patients with organ confined urothelial carcinoma following radical nephroureterectomy.
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Wheat JC, Weizer AZ, Wolf JS Jr, Lotan Y, Remzi M, Margulis V, Wood CG, Montorsi F, Roscigno M, Kikuchi E, Zigeuner R, Langner C, Bolenz C, Koppie TM, Raman JD, Fernández M, Karakiewizc P, Capitanio U, Bensalah K, and Patard JJ
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- 2012
249. Does preoperative symptom classification impact prognosis in patients with clinically localized upper-tract urothelial carcinoma managed by radical nephroureterectomy?
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Raman JD, Shariat SF, Karakiewicz PI, Lotan Y, Sagalowsky AI, Roscigno M, Montorsi F, Bolenz C, Weizer AZ, Wheat JC, Ng CK, Scherr DS, Remzi M, Waldert M, Wood CG, Margulis V, and Upper-Tract Urothelial Carcinoma Collaborative Group
- Published
- 2011
250. Need for high radiation dose (>/=70 gy) in early postoperative irradiation after radical prostatectomy: a single-institution analysis of 334 high-risk, node-negative patients.
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Cozzarini C, Montorsi F, Fiorino C, Alongi F, Bolognesi A, Da Pozzo LF, Guazzoni G, Freschi M, Roscigno M, Scattoni V, Rigatti P, and Di Muzio N
- Published
- 2009
- Full Text
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