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(1) Background: Liver metastases (LM) are the leading cause of death in colorectal cancer (CRC) patients. Despite advancements, relapse rates remain high and current prognostic nomograms lack accuracy. Our objective is to develop an interpretable neoadjuvant algorithm based on mathematical models to accurately predict individual risk, ensuring mathematical transparency and auditability. (2) Methods: We retrospectively evaluated 86 CRC patients with LM treated with neoadjuvant systemic therapy followed by complete surgical resection. A comprehensive analysis of 155 individual patient variables was performed. Logistic regression (LR) was utilized to develop the predictive model for relapse risk through significance testing and ANOVA analysis. Due to data limitations, gradient boosting machine (GBM) and synthetic data were also used. (3) Results: The model was based on data from 74 patients (12 were excluded). After a median follow-up of 58 months, 5-year relapse-free survival (RFS) rate was 33% and 5-year overall survival (OS) rate was 60.7%. Fifteen key variables were used to train the GBM model, which showed promising accuracy (0.82), sensitivity (0.59), and specificity (0.96) in predicting relapse. Similar results were obtained when external validation was performed as well. (4) Conclusions: This model offers an alternative for predicting individual relapse risk, aiding in personalized adjuvant therapy and follow-up strategies. [ABSTRACT FROM AUTHOR]

Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), was declared a pandemic by the World Health Organization in March 2020. Since then, viral spread from humans to animals has occurred worldwide. Nonhuman primates (NHPs) have been found to be susceptible to reverse‐zoonosis transmission of SARS‐CoV‐2, but initial research suggested that platyrrhine primates are less susceptible than catarrhine primates. Here we report the natural SARS‐CoV‐2 infection of a common woolly monkey (Lagothrix lagothricha) from a wildlife rehabilitation center in Ecuador. The course of the disease, the eventual death of the specimen, and the pathological findings are described. Our results show the susceptibility of a new platyrrhine species to SARS‐CoV‐2 and provide evidence for the first time of a COVID‐19‐associated death in a naturally infected NHP. The putative route of transmission from humans, and implications for captive NHPs management, are also discussed. Given that common woolly monkeys are at risk of extinction in Ecuador, further understanding of the potential threat of SARS‐CoV‐2 to their health should be a conservation priority. A One Health approach is the best way to protect NHPs from a new virus in the same way that we would protect the human population. Research Highlights: The reverse‐zoonosis transmission of severe acute respiratory syndrome coronavirus 2 is a life‐threatening challenge for the common woolly monkey (Lagothrix lagothricha).Based on the initial gastrointestinal manifestations and post‐mortem findings, we hypothesize a foodborne infection.It is necessary to reinforce the training of animal keepers on the transmission of the virus to prevent its possible spread to nonhuman primates.Together with nonpharmaceutical measures, vaccination of susceptible species could be the best way to prevent future reverse‐zoonosis transmissions. [ABSTRACT FROM AUTHOR]

Introduction: cancer and cardiovascular diseases (CVD) are among the main causes of mortality worldwide. In CVD patients, continuous moderate-intensity training and High-Intensity Interval Training (HIIT) are safe, effective, and may be a strategy to improve cardiovascular health. Material and methods: a prospective experimental study was performed with a sample of 275 cancer survivors recently diagnosed with CVD and low functional capacity, less than 4 METs (metabolic equivalent of task). A training program lasting 36 weeks was applied with assistance three times a week of 70 minutes per intervention and with pre and post-measurements of anthropometry by bioimpedance, New York Heart Association (NYHA) Scale, stress test, echocardiogram, sarcopenia (Anthropometry, muscular strength, and functionality), lipid profile, quality of life European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTG-C30), questionnaire for fatigue (FACT-Fatigue scale), 6 minutes walk test for distance traveled and estimated VO2. Results: significant improvement was reported in ejection fraction (40 ± 4.8 vs 47 ± 5.6; p ≤ 0.05), functional capacity reported in METs (2.1 ± 1.6 vs 3.9 ± 0.9), quality of life (108 ± 14 vs 121 ±7.6; p = 0.002) and improvement in estimated VO2max, strength, muscle percentage, and post-intervention blood pressure (p ≤ 0.05). In addition, the lipid profile, glucose, abdominal circumference, fat percentage (p ≤ 0.05). 0.05), and sarcopenia (32 vs 13%; p = 0.012) decreased after HIIT training without any adverse events during the interventions in the study population. Conclusions: the use of HIIT training is an efficient and safe way to improve physical capacity, quality of life, anthropometric parameters, and control cardiovascular risk factors (CVRF) in cancer survivors with a recent diagnosis of CVD. [ABSTRACT FROM AUTHOR]

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Simple Summary: To ensure long-term sustainability, the meat industry seeks to apply more sustainable practices like replacing imported traditional feedstuff (i.e., cereals) with low-cost local resources. In this sense, carob pulp (Cp), a Mediterranean by-product rich in polyphenols, represents a potential alternative to feed pigs. Polyphenols exhibit antioxidant properties comparable to vitamin E (Vit E) but may impair animal growth in high doses. This study evaluated the influence of supplementing fattening pig diets with 20% Cp and high doses of Vit E (300 IU/kg) on growth performance, economic results, physiological parameters, nutrient digestibility, and animal behaviour. While no synergistic effect between Cp and Vit E was observed, incorporating 20% Cp in pig diets during the last 40 days of the fattening period is feasible without compromising growth performance, physiology, or behaviour. However, crude protein digestibility and the feeding cost were negatively affected by Cp inclusion. Supplementation with Vit E, although not improving pig performance, increased α-tocopherol deposition in blood, potentially enhancing the antioxidant tissue profile and meat quality. This study aimed to assess the impact on growth, economic results, apparent nutrient digestibility (CTTAD), physiological variables, and animal behaviour when 214 fattening pigs (78 ± 8.5 kg of initial body weight and 130 ± 4.5 days of age) of both sexes (gilts and boars) were fed two levels of carob pulp (Cp, 0 vs. 20%) and two doses of vitamin E (Vit E, 30 vs. 300 IU/kg) for 40 days. No interaction effects between factors studied (Cp, Vit E, and sex) were observed on the variables. Most productive traits were unaffected by Cp or Vit E inclusion. However, the Cp increased the feed conversion ratio during the first 20 days. The Cp group showed a higher CTTAD of ether extract and hemicellulose but lower CTTAD of crude protein. Pigs fed Cp had a lower plasmatic urea content than the control group. The high Vit E doses increased the CTTAD of every nutrient and the plasmatic α-tocopherol content. The pigs fed Cp tended to spend more time eating in the early morning, likely to mitigate tannins' astringent effects. Dietary inclusion of 20% Cp in finishing high-conformation pigs is possible without affecting overall performance though it reduces nutrient CTTAD and increases feeding cost. Supra-nutritional doses of Vit E do not affect pig performance but increase the α-tocopherol deposition with potential antioxidant effects. [ABSTRACT FROM AUTHOR]