201. CT Radiomic Features for Predicting Resectability and TNM Staging in Thymic Epithelial Tumors
- Author
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Maria Mayoral, Gregory J. Riely, James Huang, Andreas Rimner, Junting Zheng, Jose de Arimateia Batista Araujo-Filho, Charles B. Simone, Kay See Tan, Peter Gibbs, Michelle S. Ginsberg, and Annemarie F. Shepherd
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Thymoma ,Population ,Computed tomography ,Article ,Radiomics ,medicine ,Humans ,Neoplasms, Glandular and Epithelial ,Stage (cooking) ,education ,Neoplasm Staging ,Retrospective Studies ,education.field_of_study ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Advanced stage ,Area under the curve ,Thymus Neoplasms ,TNM Staging ,Surgery ,Radiology ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business - Abstract
To explore the performance of a computed tomography based radiomics model in the preoperative prediction of resectability status and TNM staging in thymic epithelial tumors.We reviewed the last preoperative computed tomography scan of patients with thymic epithelial tumors prior to resection and pathology evaluation at our institution between February 2008 and June 2019. A total of 101 quantitative features were extracted and a radiomics model was trained using elastic net penalized logistic regressions for each aim. In the set-aside testing sets, discriminating performance of each model was assessed with area under receiver operating characteristic curve.Our final population consisted of 243 patients with: 153 (87%) thymomas, 23 (9%) thymic carcinomas, and 9 (4%) thymic carcinoids. Incomplete resections (R1 or R2) occurred in 38 (16%) patients, and 67 (28%) patients had more advanced stage tumors (stage III or IV). In the set-aside testing sets, the radiomics model achieved good performance in preoperatively predicting incomplete resections (area under receiver operating characteristic curve: 0.80) and advanced stage tumors (area under receiver operating characteristic curve: 0.70).Our computed tomography radiomics model achieved good performance to predict resectability status and staging in thymic epithelial tumors, suggesting a potential value for the evaluation of radiomic features in the preoperative prediction of surgical outcomes in thymic malignancies.
- Published
- 2022