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2,366 results on '"Rice, Kenner"'

207. PHARMACOLOGICAL CHARACTERIZATION OF A GHRELIN RECEPTOR ANTAGONIST/ INVERSE AGONIST, PF-5190457, AND ITS MAJOR ACTIVE HYDROXY METABOLITE

Author

Deschaine, Sara L., Hedegaard, Morten A., Sulima, Agnieszka, Moose, Jacob, Stock, Ingrid A., Hougland, James L., Akhlaghi, Fatemeh, Rice, Kenner C., Holst, Birgitte, Leggio, Lorenzo, Deschaine, Sara L., Hedegaard, Morten A., Sulima, Agnieszka, Moose, Jacob, Stock, Ingrid A., Hougland, James L., Akhlaghi, Fatemeh, Rice, Kenner C., Holst, Birgitte, and Leggio, Lorenzo

Published
2021

231. Role of 5-HT2A receptors in the effects of ayahuasca on ethanol self-administration using a two-bottle choice paradigm in male mice.

Author

Serra, Yasmim A., Barros-Santos, Thaísa, Anjos-Santos, Alexia, Kisaki, Natali D., Jovita-Farias, Caio, Leite, João P. C., Santana, Maria C. E., Coimbra, João P. S. A., de Jesus, Nailton M. S., Sulima, Agnieszka, Barbosa, Paulo C. R., Malpezzi-Marinho, Elena L. A., Rice, Kenner C., Oliveira-Lima, Alexandre J., Berro, Laís F., and Marinho, Eduardo A. V.

Subjects
AYAHUASCA, ALCOHOL drinking, ETHANOL, SEROTONIN, MICE
Published
2022
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240. Salvinorin A: a potent naturally occurring nonnitrogenous [kappa] opioid selective agonist

Author

Roth, Bryan L., Baner, Karen, Westkaemper, Richard, Siebert, Daniel, Rice, Kenner C., Steinberg, SeAnna, Ernsberger, Paul, and Rothman, Richard B.

Subjects
Opioids -- Receptors, Terpenes -- Physiological aspects, Biochemistry -- Research, Cloning -- Genetic aspects, Ion channels -- Physiological aspects, Acids -- Physiological aspects, Schizophrenia -- Causes of, Science and technology
Abstract

Salvia divinorum, whose main active ingredient is the neoclerodane diterpene Salvinorin A, is a hallucinogenic plant in the mint family that has been used in traditional spiritual practices for its psychoactive properties by the Mazatecs of Oaxaca, Mexico. More recently, S. divinorum extracts and Salvinorin A have become more widely used in the U.S. as legal hallucinogens. We discovered that Salvinorin A potently and selectively inhibited [sup.3]H-bremazocine binding to cloned [kappa] opioid receptors. Salvinorin A had no significant activity against a battery of 50 receptors, transporters, and ion channels and showed a distinctive profile compared with the prototypic hallucinogen lysergic acid diethylamide. Functional studies demonstrated that Salvinorin A is a potent [kappa] opioid agonist at cloned [kappa] opioid receptors expressed in human embryonic kidney-293 cells and at native [kappa] opioid receptors expressed in guinea pig brain. Importantly, Salvinorin A had no actions at the 5-H[T.sub.2A] serotonin receptor, the principal molecular target responsible for the actions of classical hallucinogens. Salvinorin A thus represents, to our knowledge, the first naturally occurring nonnitrogenous opioid-receptor subtype-selective agonist. Because Salvinorin A is a psychotomimetic selective for [kappa] opioid receptors, [kappa] opioid-selective antagonists may represent novel psychotherapeutic compounds for diseases manifested by perceptual distortions (e.g., schizophrenia, dementia, and bipolar disorders). Additionally, these results suggest that [kappa] opioid receptors play a prominent role in the modulation of human perception.

Published
2002

244. Novel chimeric monoclonal antibodies that block fentanyl effects and alter fentanyl biodistribution in mice

Author

Ban, Bhupal, primary, Barrientos, Rodell C., additional, Oertel, Therese, additional, Komla, Essie, additional, Whalen, Connor, additional, Sopko, Megan, additional, You, Yingjian, additional, Banerjee, Partha, additional, Sulima, Agnieszka, additional, Jacobson, Arthur E., additional, Rice, Kenner C., additional, Matyas, Gary R., additional, and Yusibov, Vidadi, additional

Published
2021
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250. Morphine and Fentanyl Repeated Administration Induces Different Levels of NLRP3-Dependent Pyroptosis in the Dorsal Raphe Nucleus of Male Rats via Cell-Specific Activation of TLR4 and Opioid Receptors

Author

Carranza-Aguilar, César J., primary, Hernández-Mendoza, Araceli, additional, Mejias-Aponte, Carlos, additional, Rice, Kenner C., additional, Morales, Marisela, additional, González-Espinosa, Claudia, additional, and Cruz, Silvia L., additional

Published
2020
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