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204. Cellular Cofactors Affecting Hepatitis C Virus Infection and Replication

Author

Randall, Glenn, Panis, Maryline, Cooper, Jacob D., Tellinghuisen, Timothy L., Sukhodolets, Karen E., Pfeffer, Sebastien, Landthaler, Markus, Landgraf, Pablo, Kan, Sherry, Lindenbach, Brett D., Chien, Minchen, Weir, David B., Russo, James J., Ju, Jingyue, Brownstein, Michael J., Sheridan, Robert, Sander, Chris, Zavolan, Mihaela, Tuschl, Thomas, and Rice, Charles M.

Published
2007
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208. Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins

Author

Wang, Zijun, primary, Muecksch, Frauke, additional, Cho, Alice, additional, Gaebler, Christian, additional, Hoffmann, Hans-Heinrich, additional, Ramos, Victor, additional, Zong, Shuai, additional, Cipolla, Melissa, additional, Johnson, Briana, additional, Schmidt, Fabian, additional, DaSilva, Justin, additional, Bednarski, Eva, additional, Tanfous, Tarek Ben, additional, Raspe, Raphael, additional, Yao, Kaihui, additional, Lee, Yu E., additional, Chen, Teresia, additional, Turroja, Martina, additional, Milard, Katrina G., additional, Dizon, Juan, additional, Kaczynska, Anna, additional, Gazumyan, Anna, additional, Oliveira, Thiago Y., additional, Rice, Charles M., additional, Caskey, Marina, additional, Bieniasz, Paul D., additional, Hatziioannou, Theodora, additional, Barnes, Christopher O., additional, and Nussenzweig, Michel C., additional

Published
2022
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209. System-wide transcriptome damage and tissue identity loss in COVID-19 patients

Author

Park, Jiwoon, primary, Foox, Jonathan, additional, Hether, Tyler, additional, Danko, David C., additional, Warren, Sarah, additional, Kim, Youngmi, additional, Reeves, Jason, additional, Butler, Daniel J., additional, Mozsary, Christopher, additional, Rosiene, Joel, additional, Shaiber, Alon, additional, Afshin, Evan E., additional, MacKay, Matthew, additional, Rendeiro, André F., additional, Bram, Yaron, additional, Chandar, Vasuretha, additional, Geiger, Heather, additional, Craney, Arryn, additional, Velu, Priya, additional, Melnick, Ari M., additional, Hajirasouliha, Iman, additional, Beheshti, Afshin, additional, Taylor, Deanne, additional, Saravia-Butler, Amanda, additional, Singh, Urminder, additional, Wurtele, Eve Syrkin, additional, Schisler, Jonathan, additional, Fennessey, Samantha, additional, Corvelo, André, additional, Zody, Michael C., additional, Germer, Soren, additional, Salvatore, Steven, additional, Levy, Shawn, additional, Wu, Shixiu, additional, Tatonetti, Nicholas P., additional, Shapira, Sagi, additional, Salvatore, Mirella, additional, Westblade, Lars F., additional, Cushing, Melissa, additional, Rennert, Hanna, additional, Kriegel, Alison J., additional, Elemento, Olivier, additional, Imielinski, Marcin, additional, Rice, Charles M., additional, Borczuk, Alain C., additional, Meydan, Cem, additional, Schwartz, Robert E., additional, and Mason, Christopher E., additional

Published
2022
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211. Hepatitis C Virus Polyprotein Processing

Author

Grakoui, Arash, McCourt, David W., Wychowski, Czeslaw, Lin, Chao, Feinstone, Stephen M., Rice, Charles M., Nishioka, K., editor, Suzuki, H., editor, Mishiro, S., editor, and Oda, T., editor

Published
1994
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215. Mouse characteristics that affect establishing xenografts from hepatocellular carcinoma patient biopsies in the United States

Author

Zou, Chenhui, primary, El Dika, Imane, additional, Vercauteren, Koen O. A., additional, Capanu, Marinela, additional, Chou, Joanne, additional, Shia, Jinru, additional, Pilet, Jill, additional, Quirk, Corrine, additional, Lalazar, Gadi, additional, Andrus, Linda, additional, Kabbani, Mohammad, additional, Yaqubie, Amin, additional, Khalil, Danny, additional, Mergoub, Taha, additional, Chiriboga, Luis, additional, Rice, Charles M., additional, Abou‐Alfa, Ghassan K., additional, and de Jong, Ype P., additional

Published
2021
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218. Replication and single-cycle delivery of SARS-CoV-2 replicons

Author

Ricardo-Lax, Inna, primary, Luna, Joseph M., additional, Thao, Tran Thi Nhu, additional, Le Pen, Jérémie, additional, Yu, Yingpu, additional, Hoffmann, H.-Heinrich, additional, Schneider, William M., additional, Razooky, Brandon S., additional, Fernandez-Martinez, Javier, additional, Schmidt, Fabian, additional, Weisblum, Yiska, additional, Trüeb, Bettina Salome, additional, Berenguer Veiga, Inês, additional, Schmied, Kimberly, additional, Ebert, Nadine, additional, Michailidis, Eleftherios, additional, Peace, Avery, additional, Sánchez-Rivera, Francisco J., additional, Lowe, Scott W., additional, Rout, Michael P., additional, Hatziioannou, Theodora, additional, Bieniasz, Paul D., additional, Poirier, John T., additional, MacDonald, Margaret R., additional, Thiel, Volker, additional, and Rice, Charles M., additional

Published
2021
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219. Intratumoral delivery of engineered recombinant modified vaccinia virus Ankara expressing Flt3L and OX40L generates potent antitumor immunity through activating the cGAS/STING pathway and depleting tumor-infiltrating regulatory T cells

Author

Yang, Ning, primary, Wang, Yi, additional, Liu, Shuaitong, additional, Luna, Joseph M., additional, Mazo, Gregory, additional, Tan, Adrian Y., additional, Zhang, Tuo, additional, Wang, Jiahu, additional, Yan, Wei, additional, Choi, John, additional, Rossi, Anthony, additional, Xiang, Jenny Zhaoying, additional, Rice, Charles M., additional, Merghoub, Taha, additional, Wolchok, Jedd D., additional, and Deng, Liang, additional

Published
2021
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220. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

Author

Schoggins, John W., MacDuff, Donna A., Imanaka, Naoko, Gainey, Maria D., Shrestha, Bimmi, Eitson, Jennifer L., Mar, Katrina B., Richardson, R. Blake, Ratushny, Alexander V., Litvak, Vladimir, Dabelic, Rea, Manicassamy, Balaji, Aitchison, John D., Aderem, Alan, Elliott, Richard M., Garcia-Sastre, Adolfo, Racaniello, Vincent, Snijder, Eric J., Yokoyama, Wayne M., Diamond, Michael S., Virgin, Herbert W., and Rice, Charles M.

Subjects
Adenylic acid -- Physiological aspects, Cyclic guanylic acid -- Physiological aspects, Genetic research, Biological response modifiers -- Research, Immune response -- Regulation, Immunosuppression -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The type I interferon (IFN) response protects cells from viral infection by inducing hundreds of interferon-stimulated genes (ISGs), some of which encode direct antiviral effectors (1-3). Recent screening studies have [...]

Published
2014

221. Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Author

Liehl, Peter, Zuzarte-Luis, Vanessa, Chan, Jennie, Zillinger, Thomas, Baptista, Fernanda, Carapau, Daniel, Konert, Madlen, Hanson, Kirsten K., Carret, Celine, Lassnig, Caroline, Muller, Mathias, Kalinke, Ulrich, Saeed, Mohsan, Chora, Angelo Ferreira, Golenbock, Douglas T., Strobl, Birgit, Prudencio, Miguel, Coelho, Luis P., Kappe, Stefan H., Superti-Furga, Giulio, Pichlmair, Andreas, Vigario, Ana M., Rice, Charles M., Fitzgerald, Katherine A., Barchet, Winfried, and Mota, Maria M.

Subjects
Interferon -- Health aspects, RNA -- Health aspects -- Analysis, Malaria -- Health aspects, Genetic transcription -- Health aspects -- Analysis, Biological sciences, Health
Abstract

Before they infect red blood cells and cause malaria, Plasmodium parasites undergo an obligate and clinically silent expansion phase in the liver that is supposedly undetected by the host. Here, [...]

Published
2014
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223. Hepatitis C virus infects rhesus macaque hepatocytes and simianized mice

Author

Scull, Margaret A., Shi, Chao, de Jong, Ype P., Gerold, Gisa, Ries, Moritz, von Schaewen, Markus, Donovan, Bridget M., Labitt, Rachael N., Horwitz, Joshua A., Gaska, Jenna M., Hrebikova, Gabriela, Xiao, Jing W., Flatley, Brenna, Fung, Canny, Chiriboga, Luis, Walker, Christopher M., Evans, David T., Rice, Charles M., and Ploss, Alexander

Published
2015
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224. Polymorphisms in melanoma differentiation-associated gene 5 link protein function to clearance of hepatitis C virus

Author

Hoffmann, Franziska S., Schmidt, Andreas, Chevillotte, Meike Dittmann, Wisskirchen, Christian, Hellmuth, Johannes, Willms, Simone, Gilmore, Rachel H., Glas, Jürgen, Folwaczny, Matthias, Müller, Tobias, Berg, Thomas, Spengler, Ulrich, Fitzmaurice, Karen, Kelleher, Dermot, Reisch, Nicole, Rice, Charles M., Endres, Stefan, and Rothenfusser, Simon

Published
2015
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226. Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

Author

Legrand, Nicolas, Ploss, Alexander, Balling, Rudi, Becker, Pablo D., Borsotti, Chiara, Brezillon, Nicolas, Debarry, Jennifer, de Jong, Ype, Deng, Hongkui, Di Santo, James P., Eisenbarth, Stephanie, Eynon, Elizabeth, Flavell, Richard A., Guzman, Carlos A., Huntington, Nicholas D., Kremsdorf, Dina, Manns, Michael P., Manz, Markus G., Mention, Jean-Jacques, Ott, Michael, Rathinam, Chozhavendan, Rice, Charles M., Rongvaux, Anthony, Stevens, Sean, Spits, Hergen, Strick-Marchand, Hélène, Takizawa, Hitoshi, van Lent, Anja U., Wang, Chengyan, Weijer, Kees, Willinger, Tim, and Ziegler, Patrick

Published
2009
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239. MX2 is an interferon-induced inhibitor of HIV-1 infection

Author

Kane, Melissa, Yadav, Shalini S., Bitzegeio, Julia, Kutluay, Sebla B., Zang, Trinity, Wilson, Sam J., Schoggins, John W., Rice, Charles M., Yamashita, Masahiro, Hatziioannou, Theodora, and Bieniasz, Paul D.

Subjects
Interferon -- Physiological aspects -- Health aspects, Host-parasite relationships -- Research, HIV infection -- Physiological aspects -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

HIV-1 replication can be inhibited by type I interferon (IFN), and the expression of a number of gene products with anti-HIV-1 activity is induced by type I IFN (1,2). However, none of the known antiretroviral proteins can account for the ability of type I IFN to inhibit early, preintegration phases of the HIV-1 replication cycle in human cells (3,4). Here, by comparing gene expression profiles in cell lines that differ in their ability to support the inhibitory action of IFN-α at early steps of the HIV-1 replication cycle, we identify myxovirus resistance 2 (MX2) as an interferon-induced inhibitor of HIV-1 infection. Expression of MX2 reduces permissiveness to a variety of lentiviruses, whereas depletion of MX2 using RNA interference reduces the anti-HIV-1 potency of IFN-α. HIV-1 reverse transcription proceeds normally in MX2-expressing cells, but 2-long terminal repeat circular forms of HIV-1 DNA are less abundant, suggesting that MX2 inhibits HIV-1 nuclear import, or destabilizes nuclear HIV-1 DNA. Consistent with this notion, mutations in the HIV-1 capsid protein that are known, or suspected, to alter the nuclear import pathways used by HIV-1 confer resistance to MX2, whereas preventing cell division increases MX2 potency. Overall, these findings indicate that MX2 is an effector of the anti-HIV-1 activity of type-I IFN, and suggest that MX2 inhibits HIV-1 infection by inhibiting capsid-dependent nuclear import of subviral complexes., We and others have previously identified proteins with antiretroviral activity on the basis of their differential expression in cells that are permissive or non-permissive with respect to particular steps in [...]

Published
2013
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240. Completion of the entire hepatitis C virus life cycle in genetically humanized mice

Author

Dorner, Marcus, Horwitz, Joshua A., Donovan, Bridget M., Labitt, Rachael N., Budell, William C., Friling, Tamar, Vogt, Alexander, Catanese, Maria Teresa, Satoh, Takashi, Kawai, Taro, Akira, Shizuo, Law, Mansun, Rice, Charles M., and Ploss, Alexander

Subjects
Nucleotide sequencing -- Methods, DNA sequencing -- Methods, Hepatitis C virus -- Genetic aspects, Mice -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

More than 130 million people worldwide chronically infected with hepatitis C virus (HCV) are at risk of developing severe liver disease. Antiviral treatments are only partially effective against HCV infection, and a vaccine is not available. Development of more efficient therapies has been hampered by the lack of a small animal model. Building on the observation that CD81 and occludin (OCLN) comprise the minimal set of human factors required to render mouse cells permissive to HCV entry (1), we previously showed that transient expression of these two human genes is sufficient to allow viral uptake into fully immunocompetent inbred mice (2). Here we demonstrate that transgenic mice stably expressing human CD81 and OCLN also support HCV entry, but innate and adaptive immune responses restrict HCV infection in vivo. Blunting antiviral immunity in genetically humanized mice infected with HCV results in measurable viraemia over several weeks. In mice lacking the essential cellular cofactor cyclophilin A (CypA), HCV RNA replication is markedly diminished, providing genetic evidence that this process is faithfully recapitulated. Using a cell-based fluorescent reporter activated by the NS3-4A protease we visualize HCV infection in single hepatocytes invivo. Persistently infected mice produce denovoinfectious particles, which can be inhibited with directly acting antiviral drug treatment, thereby providing evidence for the completion of the entire HCV life cycle in inbred mice. This genetically humanized mouse model opens new opportunities to dissect genetically HCV infection invivoand provides an important preclinical platform for testing and prioritizing drug candidates and may also have utility for evaluating vaccine efficacy., The narrow species tropism of HCV is incompletely understood. Mouse cells do not support viral entry and inefficiently replicate HCV RNA, but do support virion assembly and release. HCV uses [...]

Published
2013

241. Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

Author

Scheel, Troels K.H. and Rice, Charles M.

Subjects
Cell lines -- Research -- Physiological aspects, Life cycles (Biology) -- Research -- Genetic aspects, Hepatitis C virus -- Care and treatment -- Demographic aspects -- Research -- Genetic aspects, Biological sciences, Health
Abstract

More than two decades of intense research has provided a detailed understanding of hepatitis C virus (HCV), which chronically infects 2% of the world's population. This effort has paved the [...]

Published
2013
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242. Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection

Author

Guermonprez, Pierre, Helft, Julie, Claser, Carla, Deroubaix, Stephanie, Karanje, Henry, Gazumyan, Anna, Darasse-Jeze, Guillaume, Telerman, Stephanie B., Breton, Gaelle, Schreiber, Heidi A., Frias-Staheli, Natalia, Billerbeck, Eva, Dorner, Marcus, Rice, Charles M., Ploss, Alexander, Klein, Florian, Swiecki, Melissa, Colonna, Marco, Kamphorst, Alice O., Meredith, Matthew, Niec, Rachel, Takacs, Constantin, Mikhail, Fadi, Hari, Aswin, Bosque, David, Eisenreich, Tom, Merad, Miriam, Shi, Yan, Ginhoux, Florent, Renia, Laurent, Urban, Britta C., and Nussenzweig, Michel C.

Subjects
T cells -- Health aspects -- Physiological aspects -- Genetic aspects -- Research, Biological response modifiers -- Health aspects -- Physiological aspects -- Genetic aspects -- Research, Dendritic cells -- Health aspects -- Physiological aspects -- Genetic aspects -- Research, Malaria -- Development and progression -- Genetic aspects -- Research, Biological sciences, Health
Abstract

Innate sensing mechanisms trigger a variety of humoral and cellular events that are essential to adaptive immune responses. Here we describe an innate sensing pathway triggered by Plasmodium infection that [...]

Published
2013
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244. A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry

Author

Luu, Anh Phuong, primary, Yao, Zhenlan, additional, Ramachandran, Sangeetha, additional, Azzopardi, Stephanie A., additional, Miles, Linde A., additional, Schneider, William M., additional, Hoffmann, H.-Heinrich, additional, Bozzacco, Leonia, additional, Garcia, Gustavo, additional, Gong, Danyang, additional, Damoiseaux, Robert, additional, Tang, Hengli, additional, Morizono, Kouki, additional, Rudin, Charles M., additional, Sun, Ren, additional, Arumugaswami, Vaithilingaraja, additional, Poirier, John T., additional, MacDonald, Margaret R., additional, Rice, Charles M., additional, and Li, Melody M. H., additional

Published
2021
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248. A diverse range of gene products are effectors of the type I interferon antiviral response

Author

Schoggins, John W., Wilson, Sam J., Panis, Maryline, Murphy, Mary Y., Jones, Christopher T., Bieniasz, Paul, and Rice, Charles M.

Subjects
Interferon -- Health aspects -- Research -- Physiological aspects, Gene expression -- Physiological aspects -- Genetic aspects -- Health aspects -- Research, Viral genetics -- Research -- Genetic aspects -- Health aspects -- Physiological aspects, Antiviral agents -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The type I interferon response protects cells against invading viral pathogens. The cellular factors that mediate this defence are the products of interferon-stimulated genes (ISGs). Although hundreds of ISGs have [...]

Published
2011
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249. New horizons for studying human hepatotropic infections

Author

Jong, Ype P. de, Rice, Charles M., and Ploss, Alexander

Subjects
Hepatitis -- Causes of -- Care and treatment -- Research, Animal models in research -- Usage, Health care industry
Abstract

The liver serves as a target organ for several important pathogens, including hepatitis B and C viruses (HBV and HCV, respectively) and the human malaria parasites, all of which represent serious global health problems. Because these pathogens are restricted to human hepatocytes, research in small animals has been compromised by the frailty of the current mouse xenotransplantation models. In this issue of the JCI, Bissig et al. demonstrate robust HBV and HCV infection in a novel xenotransplantation model in which large numbers of immunodeficient mice with liver injury were engrafted with significant quantities of human hepatocytes. This technical advance paves the way for more widespread use of human liver chimeric mice and forms the basis for creating increasingly complex humanized mouse models that could prove useful for studying immunopathogenesis and vaccine development against hepatotropic pathogens., More than 800 million people are chronically infected with hepatitis B and C viruses (HBV and HCV, respectively) and malaria, causing over 1.5 million deaths annually (1), (2). Persistent HBV [...]

Published
2010
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250. Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents

Author

Vercauteren, Koen, Van Den Eede, Naomi, Mesalam, Ahmed Atef, Belouzard, Sandrine, Catanese, Maria Teresa, Bankwitz, Dorothea, Wong-Staal, Flossie, Cortese, Riccardo, Dubuisson, Jean, Rice, Charles M., Pietschmann, Thomas, Leroux-Roels, Geert, Nicosia, Alfredo, and Meuleman, Philip

Published
2014
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