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215. The Hexane Fraction of Bursera microphylla A. Gray Induces p21-Mediated Anti-Proliferative and Pro-Apoptotic Effects in Human Cancer-Derived Cell Lines.

Author

Adorisio, Sabrina, Fierabracci, Alessandra, Gigliarelli, Giulia, Muscari, Isabella, Cannarile, Lorenza, Liberati, Anna Marina, Marcotullio, Maria Carla, Riccardi, Carlo, Curini, Massimo, Robles Zepeda, Ramon Enrique, and Delfino, Domenico V.

Abstract

Bursera microphylla (BM), one of the common elephant trees, is widely distributed in the Sonoran Desert in Mexico. The Seri ethnic group in the Sonoran Desert uses BM as an anti-inflammatory and painkiller drug for the treatment of sore throat, herpes labialis, abscessed tooth, and wound healing. Dried stems and leaves of BM are used in a tea to relieve painful urination and to stimulate bronchial secretion. Furthermore, BM is used for fighting venereal diseases. To investigate the effects of the hexane fraction of resin methanol extract (BM-H) on cell growth, the acute myeloid cell line (OCI-AML3) was treated with 250, 25, or 2.5 µg/mL of BM-H. The first 2 concentrations were able to significantly decrease OCI-AML3 cell number. This reduced cell number was associated with decreased S-phase, blockade of the G2/M phase of the cell cycle, and increased cell death. Similar results were obtained on all tested tumor cell lines of different origins. We found that blockade of the cell cycle was due to upregulation of p21 protein in a p53-independent way. Increase of p21 was possibly due to upstream upregulation of p-ERK (which stabilizes p21 protein) and downregulation of p-38 (which promotes its degradation). Regarding cell death, activation of caspase-3, but not of caspase-8 or -9, was detectable after BM-H treatment. In conclusion, these data suggest that the BM’s hexane fraction inhibited proliferation of cell lines mainly by a p21-dependent, p53-independent mechanism and promoted apoptosis through activation of caspase-3, but not caspase-8 or -9. [ABSTRACT FROM AUTHOR]

Published
2018
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216. Comitato Scientifico

Author

Canonico, Pl, Catapano, Al, De Crescenzo, G, Riccardi, Carlo, Rossi, F, and Scatigna, M.

Published
2012

223. Moderatore

Author

Riccardi, Carlo and Berrino, L.

Published
2012

224. CD8+ T Cells: GITR Matters

Author

Ronchetti, Simona, Nocentini, Giuseppe, Petrillo, Maria Grazia, and Riccardi, Carlo

Subjects
Article Subject
Abstract

As many members of the tumor necrosis factor receptor superfamily, glucocorticoid-induced TNFR-related gene (GITR) plays multiple roles mostly in the cells of immune system. CD8+ T cells are key players in the immunity against viruses and tumors, and GITR has been demonstrated to be an essential molecule for these cells to mount an immune response. The aim of this paper is to focus on GITR function in CD8+ cells, paying particular attention to numerous and recent studies that suggest its crucial role in mouse disease models.

Published
2012
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228. Prefazione

Author

Rossi, F., Cuomo, V., and Riccardi, Carlo

Published
2011

229. Immunosoppressori

Author

Migliorati, Graziella, Nocentini, Giuseppe, and Riccardi, Carlo

Published
2011

245. Maesopsin 4-O-D-glucoside, a natural compound isolated from the leaves of Artocarpus tonkinensis, inhibits proliferation and up-regulates HMOX1, SRXN! and BCAS3 in acute myeloid leukemia

Author

Pozzesi, Nicola, Pierangeli, Sara, Vacca, Carmine, Falchi, L., Pettirossi, Valentina, Martelli, Maria Paola, Thuy, T. T., Ninh, P. T., Liberati, Anna Marina, Riccardi, Carlo, Sung, T. V., and Delfino, Domenico Vittorio

Subjects
HMOX1, proliferation, SRXN1, Maesopsin 4-O-β-D-glucoside, BCAS3, acute myeloid leukemia, Artocarpus tonkinensis
Published
2011

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