1,231 results on '"Renaud, F."'
Search Results
202. Preparation of Medical Cotton Textile Activated by Thymus leptobotrys Essential Oil Colloidal Particles: Evaluation of Antifungal Properties
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Asbahani, A. El, Addi, E., Miladi, K., Bitar, A., Casabianca, H., Mousadik, A. El, Hartmann, D., Jilale, A., Renaud, F., Elaissari, A., Laboratoire d'automatique et de génie des procédés (LAGEP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), COGEMA, Lab Biotechnol & Valorisat Nat Resources, and Université Ibn Zohr [Agadir]
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[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
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- 2014
203. Cysteine-conjugated metabolites of ginger components, shogaols, induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells
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Junsheng Fu, Huadong Chen, Shengmin Sang, Dominique N. Soroka, and Renaud F Warin
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ginger ,Catechols ,shogaols ,cysteine-conjugated metabolites ,Pharmacology ,medicine.disease_cause ,Inhibitor of apoptosis ,Article ,Proto-Oncogene Proteins ,medicine ,Humans ,Cysteine ,Caspase ,biology ,Cytochrome c ,Cell Cycle ,apoptosis ,Cytochromes c ,General Chemistry ,HCT116 Cells ,Antineoplastic Agents, Phytogenic ,Caspase 9 ,3. Good health ,XIAP ,Oxidative Stress ,colon cancer ,Apoptosis ,Cancer cell ,Colonic Neoplasms ,biology.protein ,Signal transduction ,Tumor Suppressor Protein p53 ,General Agricultural and Biological Sciences ,Apoptosis Regulatory Proteins ,HT29 Cells ,Oxidative stress ,Signal Transduction - Abstract
Shogaols, the major constituents of thermally processed ginger, have been proven to be highly effective anticancer agents. Our group has identified cysteine-conjugated shogaols (M2, M2', and M2″) as the major metabolites of [6]-, [8]-, and [10]-shogaol in human and found that M2 is a carrier of its parent molecule [6]-shogaol in cancer cells and in mice, while being less toxic to normal colon fibroblast cells. The objectives of this study are to determine whether M2' and M2″ behave in a similar manner to M2, in both metabolism and efficacy as anticancer agents, and to further explore the biological pro-apoptotic mechanisms of the cysteine-conjugated shogaols against human colon cancer cells HCT-116 and HT-29. Our results show that [8]- and [10]-shogaol have similar metabolic profiles to [6]-shogaol and exhibit similar toxicity toward human colon cancer cells. M2' and M2″ both show low toxicity against normal colon cells but retain potency against colon cancer cells, suggesting that they have similar activity to M2. We further demonstrate that the cysteine-conjugated shogaols can cause cancer cell death through the activation of the mitochondrial apoptotic pathway. Our results show that oxidative stress activates a p53 pathway that ultimately leads to p53 up-regulated modulator of apoptosis (PUMA) induction and down-regulation of B-cell lymphoma 2 (Bcl-2), followed by cytochrome c release, perturbation of inhibitory interactions of X-linked inhibitor of apoptosis protein (XIAP) with caspases, and finally caspase 9 and 3 activation and cleavage. A brief screen of the markers attenuated by the proapoptotic activity of M2 revealed similar results for [8]- and [10]-shogaol and their respective cysteine-conjugated metabolites M2' and M2″. This study highlights the cysteine-conjugated metabolites of shogaols as novel dietary colon cancer preventive agents.
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- 2014
204. Evolution of the mass, size, and star formation rate in high redshift merging galaxies
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Perret, V., Renaud, F., Epinat, B., Amram, P., Bournaud, F., Contini, T., Teyssier, R., Lambert, J.-C., Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Département d'Astrophysique (ex SAP) (DAP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institute for Theoretical Physics, Universität Zürich [Zürich] = University of Zurich (UZH), University of Zurich, Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)
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530 Physics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,methods: numerical ,1912 Space and Planetary Science ,galaxies: high-redshift ,10231 Institute for Computational Science ,galaxies: star formation ,galaxies: interactions ,3103 Astronomy and Astrophysics ,Astrophysics::Solar and Stellar Astrophysics ,galaxies: formation ,Astrophysics::Earth and Planetary Astrophysics ,galaxies: evolution ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,Astrophysics::Galaxy Astrophysics - Abstract
International audience; Context. In Λ-CDM models, galaxies are thought to grow both through continuous cold gas accretion coming from the cosmic web and episodic merger events. The relative importance of these different mechanisms at different cosmic epochs is nevertheless not yet understood well.Aims. We aim to address questions related to galaxy mass assembly through major and minor wet merging processes in the redshift range 1
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- 2014
205. Bioconcentration of the anionic surfactant linear alkylbenzene sulfonate (LAS) in the marine shrimp Palaemonetes varians: a radiotracer study
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Renaud, F, Warnau, M, Oberhansli, F, Teyssie, L, Temara, A., Rouleau, C, and Metian, M
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Uptake and depuration kinetics of dissolved [14C]C12-6-linear alkylbenzene sulfonate (LAS) were determined in the shrimp Palaemonetes varians using environmentally relevant exposure concentration. The shrimp concentrated LAS from seawater with a mean BCF value of 120 L kg-1 after a 7-day exposure. Uptake biokinetics were best described by a saturation model, with an estimated BCFss, of 159 ± 34 L kg-1, reached after 11.5 days. Shrimp weight influenced significantly BCF value with smaller individuals presenting higher affinity to LAS. To the light of a whole body autoradiography, major accumulation of LAS occurred in the cephalothorax circulatory system (gills, heart, hepatopancreas) and ocular peduncle, but not in the flesh, limiting potential transfer to human consumers. LAS depuration rate constant value of the shrimp was 1.18 ± 0.08 d-1 leading to less than 1% of remaining LAS in its tissues after 8 days of depuration.
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- 2014
206. Evaluation des performances environnementales de systèmes d’élevage deruminants en milieu tropical discriminés par l’espèce animale et le mode de conduite
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Wilfart-Monziols, Aurélie, Aubin, Joël, Boval, Maryline, Mahieu, Maurice, Naves, Michel, Renaud, F., Roussel, M., Fanchone, Audrey, Sol Agro et hydrosystème Spatialisation (SAS), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Unité de Recherches Zootechniques (URZ), Institut National de la Recherche Agronomique (INRA), École supérieure d'ingénieurs et de techniciens pour l'agriculture (ESITPA), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Institut National de Recherche Agronomique (INRA). UAR Département Physiologie Animale et Systèmes d'Elevage (0558)., AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA), and ProdInra, Archive Ouverte
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[SDV] Life Sciences [q-bio] ,[SDV]Life Sciences [q-bio] - Abstract
Faces aux nouveaux enjeux du développement durable, l’intensification raisonnée dessystèmes d’élevages est une voie allant vers l’augmentation de la production tout en minimisant leseffets négatifs sur l’environnement. Au pâturage, cette intensification prend la forme d’unaccroissement de la charge animale par hectare, ce qui n’est pas sans conséquences. En bovinsallaitants, la contrainte porte principalement sur l’augmentation du rendement des prairies. Lessolutions préconisées étaient l’augmentation de l’apport d’intrants (fertilisation, irrigation), et l’utilisationde fourrages à fort potentiel. Chez les petits ruminants, la principale contrainte est le parasitismegastro-intestinal. Une des solutions est l’association avec des bovins. Des systèmes contrastés visantà évaluer les performances de production de ces systèmes ont été mis en place en unitéexpérimentale. Pour les systèmes bovins allaitants, une base de données (BDD) a été construite àpartir du suivi d’un essaie conduit de 1999 à 2010 (Fanchone et al, 2012). Pour les systèmes mixtesbovins caprins, une autre BDD a été construite à partir d’un essaie conduit de 2007 à 2010 (Mahieu,2013). La promotion de tels systèmes auprès des éleveurs nécessite l’évaluation conjointe de leursperformances de production et de leurs performances environnementales. L’analyse de cycle de vie(ACV) a déjà été utilisée pour effectuer l’évaluation environnementale de tels systèmes en milieutempéré (Nguyen et al, 2012). Cependant, à notre connaissance, très peu de travaux sont disponiblesen milieu tropical. Par ailleurs, les données IPCC en milieu tropical proviennent pour la plupartd’adaptation de données mesurées en milieu tempérés. L’ACV a été appliqué à ces deux systèmes.Les analyses se sont limitées aux portes des systèmes, l’unité fonctionnelle était le kilogramme depoids vif. L’inventaire s’est basé sur les BDD ainsi que les nombreux travaux analytiques menéslocalement sur ces systèmes. Les équations locales ont été privilégiées relativement à celles issues dela bibliographie tropicale. Les données de l’IPCC ont été utilisées en dernier recours.
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- 2013
207. 537P - Assessment of local clinical practice for testing of mismatch repair deficiency in metastatic colorectal cancer: The need for new diagnostic guidelines prior to immunotherapy
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Cohen, R., Hain, E., Buhard, O., Guilloux, A., Bardier, A., Kaci, R., Bertheau, P., Renaud, F., Bibeau, F., Fléjou, J.-F., André, T., Svrcek, M., and Duval, A.
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- 2018
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208. The Role of Development Research Funders in Promoting Equity in Research Consortia
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Neupane, Sunisha, primary, Boulanger, Renaud F., additional, and Taylor, Peter, additional
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- 2016
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209. Erratum: Environmental regulation of cloud and star formation in galactic bars
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Renaud, F., primary, Bournaud, F., additional, Emsellem, E., additional, Agertz, O., additional, Athanassoula, E., additional, Combes, F., additional, Elmegreen, B., additional, Kraljic, K., additional, Motte, F., additional, and Teyssier, R., additional
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- 2016
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210. Multiple HABP2 variants in familial papillary thyroid carcinoma: A case-control study
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Pigny, P., primary, Crépin, M., additional, Cao, C. Do, additional, Wemeau, J.L., additional, Bauters, C. Cardot, additional, Renaud, F., additional, Leteurtre, E., additional, and Carnaille, B., additional
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- 2016
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211. The Challenge of Timely, Responsive and Rigorous Ethics Review of Disaster Research: Views of Research Ethics Committee Members
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Hunt, Matthew, primary, Tansey, Catherine M., additional, Anderson, James, additional, Boulanger, Renaud F., additional, Eckenwiler, Lisa, additional, Pringle, John, additional, and Schwartz, Lisa, additional
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- 2016
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212. FGF1 C-terminal domain and phosphorylation regulate intracrine FGF1 signaling for its neurotrophic and anti-apoptotic activities
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Delmas, E, primary, Jah, N, additional, Pirou, C, additional, Bouleau, S, additional, Le Floch, N, additional, Vayssière, J-L, additional, Mignotte, B, additional, and Renaud, F, additional
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- 2016
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213. Characterization and phylogenetic analysis of new bat astroviruses detected in Gabon, Central Africa
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ROUGERON, V., primary, SUQUET, E., additional, MAGANGA, G. D., additional, JIOLLE, D., additional, MOMBO, I. M., additional, BOURGAREL, M., additional, MOTSCH, P., additional, ARNATHAU, C., additional, DURAND, P., additional, DREXLER, F., additional, DROSTEN, C., additional, RENAUD, F., additional, PRUGNOLLE, F., additional, and LEROY, E. M., additional
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- 2016
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214. Environmental regulation of cloud and star formation in galactic bars
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Renaud, F., primary, Bournaud, F., additional, Emsellem, E., additional, Agertz, O., additional, Athanassoula, E., additional, Combes, F., additional, Elmegreen, B., additional, Kraljic, K., additional, Motte, F., additional, and Teyssier, R., additional
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- 2015
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215. DEGRADATION OF BODY ODORS AND BACTERIA BY PHOTOCATALYTIC INSOLES
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Rodriguez, C., Puzenat, E., HORVAIS, N., Renaud, F., Freney, J., BOREL, R., VETESSE, A., Guillard, C., EAU (EAU), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and IRCELYON, ProductionsScientifiques
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[CHIM.CATA] Chemical Sciences/Catalysis ,[SDE.ES] Environmental Sciences/Environmental and Society ,[CHIM.CATA]Chemical Sciences/Catalysis ,[SDE.ES]Environmental Sciences/Environmental and Society - Abstract
International @ EAU+CRL:EPU:CGU; International audience; Under the effect of physical activity human body activate the mechanism of thermoregulation by producing sweat. The incipient sweat is inherently odorless but moisture and warmth promotes the proliferation of microorganisms on the surface of the skin. In particular, sportswears and shoes are suited environments for the growth of several bacteria and fungus. These microorganisms are responsible for the degradation of the compounds present in sweat and on the skin surface, in malodorous molecules. To address this problem of odor associated with perspiration, it seems appropriate to confer to textiles a function against micro-organisms and odorant molecules. The way explored in this work is the use of photocatalysis [1] in order to inhibit the growth of bacteria and to directly destroy the malodorous compounds. During this project, various catalysts and impregnation methods of the textile with catalysts were investigated. Optimized the amount of catalyst was determined in term of adhesion and performances. Their photocatalytic activities were first evaluated in aqueous phase with their performances on the formic acid photocatalytic oxidation. Then, an experimental setup, including an electronic nose, was designed to evaluate the photocatalytic activity in gas phase. The performances of these materials have been studied under UV light on the degradation of isovaleric acid, a model smelly compound. The efficiency of these materials under UV-A lamp and LEDs centered at a wavelength of 365 nm were compared and the photonic flux optimized. Complemently, the adhesion of the catalyst is evaluated by mechanical tests such as leaching (ISO 6330) or abrasion tests (ISO 12947-2). In parallel, bacteriological tests on the strain S.epidermidis, responsible for foot malodor, was performed using the ISO 20743 standard with and without photocatalysis. The influence of the exposition time and UV-A irradiation flux were studied on the degradation of this bacteria. Photocatalytic textiles have clearly shown an ability to degrade isovaleric acid in air and formic acid in water with a rate increasing with the increase of the quantity of titania deposited on the textile. The optimal coverage of photocatalyst and degradation rate have been determined in each case. These textiles also present antimicrobial activity after a few time under UV-A light and no effect on these bacteria in darkness, that could be consider as a proof of undestroying cutaneous flora. Reference [1]S. Silver, L.T. Phung, G. Silver, Journal of Industrial Microbiology & Biotechnology, 33 (2006) 627-634.
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- 2013
216. Engaging communities in tuberculosis research
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Alicia Y Chou, Stephanie Seidel, Lee Pyne-Mercier, Erica Lessem, Laia Ruiz Mingote, Renaud F. Boulanger, Sharon D. Williams, James V. Lavery, and Cherise Scott
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Clinical Trials as Topic ,Community-Based Participatory Research ,Tuberculosis ,Biomedical Research ,Consensus ,Community engagement ,business.industry ,Environmental resource management ,Human immunodeficiency virus (HIV) ,Antitubercular Agents ,Citizen journalism ,Public relations ,medicine.disease_cause ,medicine.disease ,Clinical trial ,Infectious Diseases ,Acquired immunodeficiency syndrome (AIDS) ,Conceptual framework ,Political science ,medicine ,Humans ,Cooperative Behavior ,business - Abstract
Summary According to a growing consensus among biomedical researchers, community engagement can improve the ethics and outcomes of clinical trials. Although successful efforts to develop community engagement practices in HIV/AIDS research have been reported, little attention has been given to engagement with the community in tuberculosis research. This article aims to draw attention to some existing community engagement initiatives in tuberculosis research and to resources that might help tuberculosis researchers to establish and implement community engagement programmes for their trials. One of these resources—the good participatory practice guidelines for tuberculosis drug trials—offers a conceptual framework and practical guidance for community engagement in tuberculosis research. To build momentum and to improve community engagement, lessons need to be shared, and formal assessment strategies for community engagement initiatives need to be developed. To build successfully on the promising activities described in this personal view, research funders and sponsors should show leadership in allocation of resources for the implementation and assessment of community engagement programmes in tuberculosis trials.
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- 2013
217. An ecosystem-based approach to evaluate the status of Mediterranean habitats
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Renaud, F, Personnic, S, Ruitton, S, Thibaut Botha, D, Boudouresque, Cf, David, R, Montefalcone, Monica, 64 scientists from the community of Mediterranean marine Sciences, and Féral, Jp
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- 2013
218. Of parasites and men
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Banuls, Anne-Laure, Thomas, F., and Renaud, F.
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Ecology ,Evolution ,Human biology ,Host-parasite interactions ,Pathogens - Abstract
The living world has evolved and is evolving through interspecific relationships between organisms. The diversity of these interactions is enormous going from mutualism to parasitism. Humans live with a multitude of microorganisms, essential for their biology. However, interactions are not always advantageous. Indeed, many organisms might become pathogens, such as the Plasmodium species, the causative agents of malaria. Like many other microorganisms, they are << Machiavellian >> in their capacity to elaborate a range of reproduction strategies, giving them a huge advantage in terms of adaptation. Here, we discuss the role played by parasites in the ecology and evolution of living organisms and particularly of humans. In the study of infectious diseases, humans are legitimately the focal point, although they represent only one ecosystem among many others and not taking this into account certainly biases our global view of the system. Indeed, we know only a minimal fraction of the microorganisms we live with. However, parasites have shaped and are still shaping the human genome. Several genetic signatures are the proofs of the selection pressures by parasites that humankind has endured during its evolution. But, ultimately, what are the solutions for living with pathogens? Should we eradicate them or should we learn how to control and manage them? (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
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- 2013
219. The Case for Local Ethics Oversight in International Development Research.
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Cochrane, Logan, Boulanger, Renaud F., Sheikheldin, Gussai H., and Song, Gloria
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ETHICS committees , *NONGOVERNMENTAL organization personnel , *DECOLONIZATION , *ACQUISITION of data , *SOCIAL sciences - Abstract
This paper argues that international development research should be submitted to the oversight of research ethics committees from the countries where data will be collected. This includes research conducted by individuals who may fall outside the jurisdictions of most ethics guidelines or policies, such as individuals contracted by nongovernmental organizations. The argument is grounded in an understanding of social justice that recognizes that not seeking local ethics approval can be an affront to the decolonization movement, and may lead to significant direct harms to participants. Local ethics oversight can help ensure projects appropriately take into consideration local laws, regulations, priorities and context. For example, a local research ethics committee may be in a better position than a foreign one to assess whether any given proposed project carries context-specific risks. In addition, submitting to a local research ethics committee is to acknowledge the legitimacy of local authorities, thereby taking a stance against the history of colonizing disempowerment. Local oversight is a mechanism to increase the accountability of researchers working abroad: if respect for local authority and tailoring to local context are to be upheld, there must be mechanisms to ensure that research that does not meet these requirements does not proceed. Objections based on the limited oversight capacity in some countries and on concerns related to the politicization of the review process are discussed. Finally, the roles and responsibilities of the various stakeholders in the implementation of greater local ethics oversight are laid out. [ABSTRACT FROM AUTHOR]
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- 2018
220. Morphology and enhanced star formation in a Cartwheel-like ring galaxy.
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Renaud, F., Athanassoula, E., Amram, P., Bosma, A., Bournaud, F., Duc, P. -A., Epinat, B., Fensch, J., Kraljic, K., Perret, V., and Struck, C.
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STAR formation , *DISK galaxies , *STAR clusters , *SUPERGIANT stars ,CARTWHEEL (Galaxy) - Abstract
We use hydrodynamical simulations of a Cartwheel-like ring galaxy, modelled as a nearly head-on collision of a small companion with a larger disc galaxy, to probe the evolution of the gaseous structures and flows, and to explore the physical conditions setting the star formation activity. Star formation is first quenched by tides as the companion approaches, before being enhanced shortly after the collision. The ring ploughs the disc material as it radially extends, and almost simultaneously depletes its stellar and gaseous reservoir into the central region, through the spokes, and finally dissolve 200 Myr after the collision. Most of star formation first occurs in the ring before this activity is transferred to the spokes and then the nucleus.We thus propose that the location of star formation traces the dynamical stage of ring galaxies, and could help constrain their star formation histories. The ring hosts tidal compression associated with strong turbulence. This compression yields an azimuthal asymmetry, with maxima reached in the side furthest away from the nucleus, which matches the star formation activity distribution in our models and in observed ring systems. The interaction triggers the formation of star clusters significantly more massive than before the collision, but less numerous than in more classical galaxy interactions. The peculiar geometry of Cartwheel-like objects thus yields a star (cluster) formation activity comparable to other interacting objects, but with notable second order differences in the nature of turbulence, the enhancement of the star formation rate, and the number of massive clusters formed. [ABSTRACT FROM AUTHOR]
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- 2018
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221. Ethical implications of diversity in disaster research
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James A Anderson, Matthew Hunt, and Renaud F. Boulanger
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Male ,Biomedical Research ,Attitude of Health Personnel ,Poison control ,Disaster Planning ,Principle-Based Ethics ,Political science ,Cultural diversity ,Humans ,ComputingMilieux_MISCELLANEOUS ,Ethical code ,Research ethics ,Operationalization ,Emergency management ,business.industry ,Health Priorities ,Disaster research ,General Medicine ,Cultural Diversity ,Health Planning ,Emergency Medicine ,Engineering ethics ,Female ,business ,Attitude to Health - Abstract
Enhancing the effectiveness, efficiency, and fairness of interventions is an increasing source of concern in the field of disaster response. As a result, the expansion of the disaster relief evidence base has been identified as a pressing need. There has been a corresponding increase in discussions of ethical standards and procedures for disaster research. In general, these discussions have focused on elucidating how traditional research ethics concerns can be operationalized in disaster settings. Less attention has been given to the exploration of the ethical implications of heterogeneity within the field of disaster research. Hence, while current efforts to discuss the ethics of disaster research in low-resource settings are very encouraging, it is clear that further initiatives will be crucial to promote the ethical conduct of disaster research. In this article, we explore how the ethical review of disaster research conducted in low-resource settings should account for this diversity. More specifically, we consider how the nature of the project (what?), sociopolitical and physical environment of research sites (where?), temporal proximity to the disaster event (when?), objectives motivating the research (why?), and identity of the stakeholders involved in the research process (who?) all relate to the ethics of disaster research.
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- 2012
222. Volume Rendering of AMR Simulations
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Labadens, M., Pomarède, D., Chapon, D., Romain Teyssier, Bournaud, F., Renaud, F., and Grandjouan, N.
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FOS: Computer and information sciences ,Computer Science - Data Structures and Algorithms ,Data Structures and Algorithms (cs.DS) - Abstract
High-resolution simulations often rely on the Adaptive Mesh Resolution (AMR) technique to optimize memory consumption versus attainable precision. While this technique allows for dramatic improvements in terms of computing performance, the analysis and visualization of its data outputs remain challenging. The lack of effective volume renderers for the octree-based AMR used by the RAMSES simulation program has led to the development of the solutions presented in this paper. Two custom algorithms are discussed, based on the splatting and the ray-casting techniques. Their usage is illustrated in the context of the visualization of a high-resolution, 6000-processor simulation of a Milky Way-like galaxy. Performance obtained in terms of memory management and parallelism speedup are presented.
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- 2012
223. Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation
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Renaud F Warin, Huadong Chen, Yingdong Zhu, Dominique N. Soroka, and Shengmin Sang
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Phytochemistry ,Metabolite ,Phytopharmacology ,Phytochemicals ,Catechols ,lcsh:Medicine ,Antineoplastic Agents ,Apoptosis ,Pharmacology ,Biology ,Ginger ,Cell Line ,03 medical and health sciences ,chemistry.chemical_compound ,Synthesis ,0302 clinical medicine ,Molecular Cell Biology ,Basic Cancer Research ,Humans ,lcsh:Science ,030304 developmental biology ,0303 health sciences ,Multidisciplinary ,TUNEL assay ,Cell Death ,lcsh:R ,Chemical Reactions ,Shogaol ,HCT116 Cells ,3. Good health ,Chemistry ,chemistry ,Biochemistry ,Terminal deoxynucleotidyl transferase ,Oncology ,Cell culture ,030220 oncology & carcinogenesis ,Cancer cell ,Medicine ,lcsh:Q ,Growth inhibition ,Synthetic Chemistry ,Drug metabolism ,Research Article - Abstract
Our previous study found that [6]-shogaol, a major bioactive component in ginger, is extensively metabolized in cancer cells and in mice. It is unclear whether these metabolites retain bioactivity. The aim of the current study is to synthesize the major metabolites of [6]-shogaol and evaluate their inhibition of growth and induction of apoptosis in human cancer cells. Twelve metabolites of [6]-shogaol (M1, M2, and M4-M13) were successfully synthesized using simple and easily accessible chemical methods. Growth inhibition assays showed that most metabolites of [6]-shogaol had measurable activities against human cancer cells HCT-116 and H-1299. In particular, metabolite M2 greatly retained the biological activities of [6]-shogaol, with an IC(50) of 24.43 µM in HCT-116 human colon cancer cells and an IC(50) of 25.82 µM in H-1299 human lung cancer cells. Also exhibiting a relatively high potency was thiol-conjugate M13, with IC(50) values of 45.47 and 47.77 µM toward HCT-116 and H-1299 cells, respectively. The toxicity evaluation of the synthetic metabolites (M1, M2, and M4-M13) against human normal fibroblast colon cells CCD-18Co and human normal lung cells IMR-90 demonstrated a detoxifying metabolic biotransformation of [6]-shogaol. The most active metabolite M2 had almost no toxicity to CCD-18Co and IMR-90 normal cells with IC(50)s of 99.18 and 98.30 µM, respectively. TUNEL (Terminal deoxynucleotidyl transferase dUTP nick end labeling) assay indicated that apoptosis was triggered by metabolites M2, M13, and its two diastereomers M13-1 and M13-2. There was no significant difference between the apoptotic effect of [6]-shogaol and the effect of M2 and M13 after 6 hour treatment.
- Published
- 2012
224. The Challenge of Timely, Responsive and Rigorous Ethics Review of Disaster Research: Views of Research Ethics Committee Members
- Author
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Catherine M. Tansey, Lisa Schwartz, Lisa Eckenwiler, James Anderson, Renaud F. Boulanger, Matthew Hunt, and John Pringle
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Male ,Critical Care and Emergency Medicine ,Time Factors ,Science Policy ,Natural Disasters ,Culture ,Psychological intervention ,lcsh:Medicine ,Social Sciences ,Poison control ,Research and Analysis Methods ,0603 philosophy, ethics and religion ,Ethics, Research ,Disasters ,03 medical and health sciences ,0302 clinical medicine ,Sociology ,Medicine and Health Sciences ,Humans ,Medicine ,Public and Occupational Health ,030212 general & internal medicine ,lcsh:Science ,Natural disaster ,Research ethics ,Social Research ,Multidisciplinary ,business.industry ,lcsh:R ,Health services research ,Disaster research ,06 humanities and the arts ,Research Assessment ,Social research ,Health Care ,Earth Sciences ,lcsh:Q ,Female ,Science policy ,Engineering ethics ,Health Services Research ,060301 applied ethics ,business ,Research Article ,Ethics Committees, Research - Abstract
BACKGROUND: Research conducted following natural disasters such as earthquakes, floods or hurricanes is crucial for improving relief interventions. Such research, however, poses ethical, methodological and logistical challenges for researchers. Oversight of disaster research also poses challenges for research ethics committees (RECs), in part due to the rapid turnaround needed to initiate research after a disaster. Currently, there is limited knowledge available about how RECs respond to and appraise disaster research. To address this knowledge gap, we investigated the experiences of REC members who had reviewed disaster research conducted in low- or middle-income countries. METHODS: We used interpretive description methodology and conducted in-depth interviews with 15 respondents. Respondents were chairs, members, advisors, or coordinators from 13 RECs, including RECs affiliated with universities, governments, international organizations, a for-profit REC, and an ad hoc committee established during a disaster. Interviews were analyzed inductively using constant comparative techniques. RESULTS: Through this process, three elements were identified as characterizing effective and high-quality review: timeliness, responsiveness and rigorousness. To ensure timeliness, many RECs rely on adaptations of review procedures for urgent protocols. Respondents emphasized that responsive review requires awareness of and sensitivity to the particularities of disaster settings and disaster research. Rigorous review was linked with providing careful assessment of ethical considerations related to the research, as well as ensuring independence of the review process. CONCLUSION: Both the frequency of disasters and the conduct of disaster research are on the rise. Ensuring effective and high quality review of disaster research is crucial, yet challenges, including time pressures for urgent protocols, exist for achieving this goal. Adapting standard REC procedures may be necessary. However, steps should be taken to ensure that ethics review of disaster research remains diligent and thorough. Language: en
- Published
- 2016
225. Epidemiology of Tick-Borne Borreliosis in Morocco
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Diatta, G., Souidi, Y., Granjon, Laurent, Arnathau, C., Durand, P., Chauvancy, Gilles, Mane, Y., Sarih, M., Belghyti, D., Renaud, F., Trape, Jean-François, Unité de Pathogénie Afro-Tropicale, Institut de Recherche pour le Développement (IRD [France-Sud]), Faculté des Sciences [Kenitra], Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Institut Pasteur du Maroc, Réseau International des Instituts Pasteur (RIIP), Université Ibn Tofaïl (UIT), Health, Emergence, Adaptation and Transmission (MIVEGEC-HEAT), Processus Écologiques et Évolutifs au sein des Communautés (PEEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)
- Subjects
DNA, Bacterial ,Male ,lcsh:Arctic medicine. Tropical medicine ,Adolescent ,lcsh:RC955-962 ,Molecular Sequence Data ,Rodentia ,Disease Vectors ,In Vitro Techniques ,Rodents ,Polymerase Chain Reaction ,Rodent Diseases ,Ticks ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,parasitic diseases ,Animals ,Humans ,Borrelia infection ,Child ,Ornithodoros ,Biology ,Mammals ,lcsh:Public aspects of medicine ,Borrelia ,Infant ,lcsh:RA1-1270 ,Sequence Analysis, DNA ,bacterial infections and mycoses ,Morocco ,Child, Preschool ,Africa ,Medicine ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Female ,Borrelia Infections ,Research Article - Abstract
Background The presence in Morocco of Argasid ticks of the Ornithodoros erraticus complex, the vector of tick-borne relapsing fever (TBRF) in North Africa, has been known since 1919, but the disease is rarely diagnosed and few epidemiological data are available. Methodology/Principal Findings Between 2006 and 2011, we investigated the presence of Ornithodoros ticks in rodent burrows in 34 sites distributed across Morocco. We also collected small mammals in 10 sites and we investigated TBRF in febrile patients in Kenitra district. The prevalence of Borrelia infections was assessed by nested PCR amplification in ticks and the brain tissue of small mammals, and by evaluation of thick blood films in patients. A high proportion of burrows were infested with ticks of the O. erraticus complex in all regions of Morocco, with a mean of 39.5% for the whole country. Borrelia infections were found in 39/382 (10.2%) of the ticks and 12/140 (8.6%) of the rodents and insectivores studied by PCR amplification, and 102 patients tested positive by thick blood film. Five small mammalian species were found infected: Dipodillus campestris, Meriones shawi, Gerbillus hoogstrali, Gerbillus occiduus and Atelerix algirus. Three Borrelia species were identified in ticks and/or rodents: B. hispanica, B. crocidurae and B. merionesi. Conclusions/Significance Tick populations belonging to O. erraticus complex are widely distributed in Morocco and a high proportion of ticks and small mammals are infected by Borrelia species. Although rarely diagnosed, TBRF may be a common cause of morbidity in all regions of Morocco., Author Summary In North Africa, Argasid ticks of the Ornithodoros erraticus complex are the only known vector of Borrelia infections causing tick-borne relapsing fever (TBRF) in humans. There is limited data on vector distribution, the animal reservoir of the disease has never been investigated, and there is no published data on TBRF patients. Our aim was to systematically investigate the distribution of O. erraticus s.l. in most regions of Morocco, to measure the proportion of infected ticks, to identify small mammalian species that act as potential reservoir, and to analyze data on TBRF patients fortuitously collected during a malaria eradication program. Our study shows that a high proportion of rodent burrows are colonized by vector ticks in all regions of Morocco from the Atlantic Sahara to the Mediterranean coast. We identified three Borrelia species in ticks and/or small mammals: B. hispanica, B. crocidurae and B. merionesi. We report five species of small mammals found infected for the first time. Our analysis of 102 TBRF patients shows that the disease is strictly seasonal in northwestern Morocco with a maximum incidence during summer. We believe that TBRF, although rarely diagnosed, is a common cause of morbidity in all regions of Morocco.
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- 2012
226. Evaluation of antimicrobial activity of a polyhexamethylène biguanide-coated textile by monitoring both baterial growth (ISO 20743/2005 Standard) and viability (live/dead baclight kit)
- Author
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Chadeau, Elise, Brunon, Céline, Degraeve, Pascal, Léonard, Didier, Grossiord, Carol, Bessueille, François, Cottaz, A., Renaud, F., Ferreira, I., Darroux, C., Simon, F., Oulahal, N., Bioingénierie et Dynamique Microbienne aux Interfaces Alimentaires (BIODYMIA), Isara-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, SIMS - Surfaces-(bio)Interfaces - Micro & Nano Systèmes (2011-2014), Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Science et Surface, Régénération tissulaire, interactions biologiques et biomatériaux (RTI2B), Université Claude Bernard Lyon 1 (UCBL), Institut Français du Textile et de l'Habillement (IFTH), Institut Français du Textile et de l'Habillement - IFTH, TDV Industrie, TDV, 'Actiprotex' research program supported by 'Fonds Unique Interministeriel' (competitivity cluster Techtera), and Région Rhône-Alpes (PhD grants - Elise Chadeau, Céline Brunon)
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[SDV.BIO]Life Sciences [q-bio]/Biotechnology ,[CHIM.ANAL]Chemical Sciences/Analytical chemistry ,NONCULTURABLE STATE ,CELLS ,WATER ,IN-VITRO ,ENUMERATION ,BIOFILM ,[INFO.INFO-BT]Computer Science [cs]/Biotechnology ,LISTERIA-MONOCYTOGENES ,EFFICACY ,ANTISEPTICS ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
International audience; Antimicrobial textiles (65% cotton - 35% polyester) were functionalized using a patented technology that combines an antimicrobial molecule - polyhexamethylene biguanide (PHMB) and a precipitating agent - sodium laurylsulphate. Surface characterization was performed by x-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry, and both techniques made clear signatures of PHMB at the top surface of treated textiles. Washing led to a strong decrease of PHMB concentration at the surface. Comparison of textile surface analysis and antimicrobial tests indicated that the amount of PHMB at its extreme surface of textiles after five or 10 industrial washings was sufficient to inhibit Listeria innocua but not Pseudomonas aeruginosa growth. The viability of L. innocua cells after contact with PHMB-treated textile after one industrial washing was estimated using the Live/Dead BacLight kit (Molecular Probes, Eugene, OR): the combination of epifluorescence microscopy observations coupled with classic enumeration allowed detection of the presence of viable but nonculturable cells.
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- 2012
227. Metabolism of [6]-Shogaol in Mice and in Cancer Cells
- Author
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Tiffany A. Parks, Dominique N. Soroka, Shengmin Sang, Yingdong Zhu, Lishuang Lv, Huadong Chen, Xiaoxin Chen, Yuhui Hu, and Renaud F Warin
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Spectrometry, Mass, Electrospray Ionization ,Magnetic Resonance Spectroscopy ,Metabolite ,Catechols ,Pharmaceutical Science ,Apoptosis ,Ginger ,chemistry.chemical_compound ,Feces ,Mice ,Cell Line, Tumor ,Animals ,Anticarcinogenic Agents ,Humans ,Mercapturic acid ,Biotransformation ,Chromatography, High Pressure Liquid ,Cell Proliferation ,Pharmacology ,Molecular Structure ,Cell growth ,Plant Extracts ,Metabolism ,Shogaol ,Articles ,Mice, Inbred C57BL ,chemistry ,Biochemistry ,Cell culture ,Cancer cell ,Female - Abstract
Ginger has received extensive attention because of its antioxidant, anti-inflammatory, and antitumor activities. However, the metabolic fate of its major components is still unclear. In the present study, the metabolism of [6]-shogaol, one of the major active components in ginger, was examined for the first time in mice and in cancer cells. Thirteen metabolites were detected and identified, seven of which were purified from fecal samples collected from [6]-shogaol-treated mice. Their structures were elucidated as 1-(4'-hydroxy-3'-methoxyphenyl)-4-decen-3-ol (M6), 5-methoxy-1-(4'-hydroxy-3'-methoxyphenyl)-decan-3-one (M7), 3',4'-dihydroxyphenyl-decan-3-one (M8), 1-(4'-hydroxy-3'-methoxyphenyl)-decan-3-ol (M9), 5-methylthio-1-(4'-hydroxy-3'-methoxyphenyl)-decan-3-one (M10), 1-(4'-hydroxy-3'-methoxyphenyl)-decan-3-one (M11), and 5-methylthio-1-(4'-hydroxy-3'-methoxyphenyl)-decan-3-ol (M12) on the basis of detailed analysis of their (1)H, (13)C, and two-dimensional NMR data. The rest of the metabolites were identified as 5-cysteinyl-M6 (M1), 5-cysteinyl-[6]-shogaol (M2), 5-cysteinylglycinyl-M6 (M3), 5-N-acetylcysteinyl-M6 (M4), 5-N-acetylcysteinyl-[6]-shogaol (M5), and 5-glutathiol-[6]-shogaol (M13) by analysis of the MS(n) (n = 1-3) spectra and comparison to authentic standards. Among the metabolites, M1 through M5, M10, M12, and M13 were identified as the thiol conjugates of [6]-shogaol and its metabolite M6. M9 and M11 were identified as the major metabolites in four different cancer cell lines (HCT-116, HT-29, H-1299, and CL-13), and M13 was detected as a major metabolite in HCT-116 human colon cancer cells. We further showed that M9 and M11 are bioactive compounds that can inhibit cancer cell growth and induce apoptosis in human cancer cells. Our results suggest that 1) [6]-shogaol is extensively metabolized in these two models, 2) its metabolites are bioactive compounds, and 3) the mercapturic acid pathway is one of the major biotransformation pathways of [6]-shogaol.
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- 2012
228. Metabolism of [6]‐shogaol in mice and in cancer cells
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Renaud F Warin, Huadong Chen, and Shengmin Sang
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chemistry.chemical_compound ,Chemistry ,Cancer cell ,Genetics ,Cancer research ,Metabolism ,Shogaol ,Molecular Biology ,Biochemistry ,Biotechnology - Published
- 2012
229. Les espèces du genre Scedosporium : des pathogènes émergents
- Author
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Symoens, Françoise, Bouchara, Jean-Philippe, Favennec, Loïc, Freney, J., Grillot, R., Leclercq, R., Lepargneur, J.P., Paugam, A., Pozzetto, Bruno, Renaud, F., Riegel, P., Public Health and Surveillance [Brussels], Institut Scientifique de Santé Publique [Belgique] - Scientific Institute of Public Health [Belgium] (WIV-ISP), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Appareil Digestif Environnement Nutrition (ADEN ), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Laboratoire d'Ecologie Microbienne - UMR 5557 (LEM), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Ecole Nationale Vétérinaire de Lyon (ENVL), Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Groupe Immunité des Muqueuses et Agents Pathogènes (GIMAP), Université Jean Monnet [Saint-Étienne] (UJM), Régénération tissulaire, interactions biologiques et biomatériaux (RTI2B), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Les Hôpitaux Universitaires de Strasbourg (HUS), Institut de bactériologie, and Fédération de Médecine Translationelle de Strasbourg (FMTS)
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[SDV]Life Sciences [q-bio] - Published
- 2012
230. Aligning community engagement with traditional authority structures in global health research: a case study from northern Ghana
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Sunita V S Bandewar, Paulina Tindana, Renaud F. Boulanger, Raymond A. Aborigo, James V. Lavery, Pamela Kolopack, Linda Rozmovits, and Abraham Hodgson
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Biomedical Research ,Local Government ,Community building ,Community engagement ,business.industry ,Community organization ,Public Health, Environmental and Occupational Health ,Community Participation ,Public relations ,Focus Groups ,Traditional authority ,Social engagement ,Focus group ,Ghana ,Organizational Case Studies ,Humans ,Sociology ,Public engagement ,business ,Social disruption ,Health Policy and Ethics ,State Government - Abstract
Despite the recognition of its importance, guidance on community engagement practices for researchers remains underdeveloped, and there is little empirical evidence of what makes community engagement effective in biomedical research. We chose to study the Navrongo Health Research Centre in northern Ghana because of its well-established community engagement practices and because of the opportunity it afforded to examine community engagement in a traditional African setting. Our findings suggest that specific preexisting features of the community have greatly facilitated community engagement and that using traditional community engagement mechanisms limits the social disruption associated with research conducted by outsiders. Finally, even in seemingly ideal, small, and homogeneous communities, cultural issues exist, such as gender inequities, that may not be effectively addressed by traditional practices alone.
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- 2011
231. Insulin a survival factor for olfactory mucosa
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Lacroix, Marie-Christine, Rodriguez-Enfedaque, A., Laziz, Iman, Monnerie, Regine, Grebert, Denise, Rivière, Sébastien, Caillol, Monique, Renaud, F., ProdInra, Migration, Neurobiologie de l'Olfaction et Modélisation en Imagerie (NOeMI), Institut National de la Recherche Agronomique (INRA), Institut Fédératif de Recherche 144 (NeuroSud Paris) (IFR 144), Laboratoire de génétique et biologie cellulaire (LGBC), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)
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insulin ,[CHIM.OTHE] Chemical Sciences/Other ,olfactory mucosa ,[CHIM.OTHE]Chemical Sciences/Other ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 2011
232. Plasmodium falciparum is not as lonely as previously considered
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Prugnolle, F, Ayala, FJ, Ollomo, B, Arnathau, C, Durand, P, and Renaud, F
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Great apes ,virulence ,Plasmodium ,speciation ,parasitic diseases ,origin ,Laverania ,diversity - Abstract
Until very recently, only one species (P. reichenowi) was known to be a phylogenetic sister lineage of P. falciparum, the main malignant agent of human malaria. In 2009 and 2010, new studies have revealed the existence of several new phylogenetic species related to this deadly parasite and infecting chimpanzees and gorillas in Africa. These discoveries invite us to explore a whole set of new questions, which we briefly do in this article.
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- 2011
233. Sorption-desorption kinetics and toxic cell concentration in marine phytoplankton microalgae exposed to Linear Alkylbenzene Sulfonate
- Author
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Renaud, F., Oberhansli, F., Teyssie, J.L., Miramand, P., Temara, A., and Warnau, M.
- Abstract
Linear Alkylbenzene Sulfonates (LAS) are ubiquitous surfactants. Traces can be found in coastal environments. Sorption and toxicity of C12-LAS congeners were studied in controlled conditions (2-3500 µg C12LAs/L) in five marine phytoplanktonic species, using standardized methods. IC50 values ranged from 0.5 to 2 mg LAS/L. Sorption of 14C12-6 LAS isomer was measured at environmentally relevant trace levels (4 µg/L) using liquid scintillation counting. Steady-state sorption on algae was reached within 5 h in the order dinoflagellate > diatoms > green algae. The sorption data, fitted a L-type Freundlich isotherm, indicating saturation. Desorption was rapid but a low LAS fraction was still sorbed after 24 h. Toxic cell concentration was 0.38 +/- 0.09 mg/g for the studied species. LAS toxicity results from sorption on biological membranes leading to non-specific disturbance of algal growth. Results indicate that LAS concentrations in coastal environments do not represent a risk for these organisms.
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- 2011
234. An extremely young massive clump forming by gravitational collapse in a primordial galaxy
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Zanella, A., primary, Daddi, E., additional, Le Floc’h, E., additional, Bournaud, F., additional, Gobat, R., additional, Valentino, F., additional, Strazzullo, V., additional, Cibinel, A., additional, Onodera, M., additional, Perret, V., additional, Renaud, F., additional, and Vignali, C., additional
- Published
- 2015
- Full Text
- View/download PDF
235. Large and small-scale structures and the dust energy balance problem in spiral galaxies
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Saftly, W., primary, Baes, M., additional, De Geyter, G., additional, Camps, P., additional, Renaud, F., additional, Guedes, J., additional, and De Looze, I., additional
- Published
- 2015
- Full Text
- View/download PDF
236. Animal behaviour and cancer
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Vittecoq, M., primary, Ducasse, H., additional, Arnal, A., additional, Møller, A.P., additional, Ujvari, B., additional, Jacqueline, C.B., additional, Tissot, T., additional, Missé, D., additional, Bernex, F., additional, Pirot, N., additional, Lemberger, K., additional, Abadie, J., additional, Labrut, S., additional, Bonhomme, F., additional, Renaud, F., additional, Roche, B., additional, and Thomas, F., additional
- Published
- 2015
- Full Text
- View/download PDF
237. Antimicrobial Activity of Nano-Encapsulated Essential Oils: Comparison to Non-Encapsulated Essential Oils
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Asbahani, A. El, primary, Miladi, K., additional, Addi, E. H. Aït, additional, Bitar, A., additional, Casabianca, H., additional, Mousadik, A. El, additional, Hartmann, D. J., additional, Jilale, A., additional, Renaud, F. N. R., additional, and Elaissari, A., additional
- Published
- 2015
- Full Text
- View/download PDF
238. Modeling CO emission from hydrodynamic simulations of nearby spirals, starbursting mergers, and high-redshift galaxies
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Bournaud, F., primary, Daddi, E., additional, Weiß, A., additional, Renaud, F., additional, Mastropietro, C., additional, and Teyssier, R., additional
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- 2015
- Full Text
- View/download PDF
239. Pesticide pollution of multiple drinking water sources in the Mekong Delta, Vietnam: evidence from two provinces
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Chau, N. D. G., primary, Sebesvari, Z., additional, Amelung, W., additional, and Renaud, F. G., additional
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- 2015
- Full Text
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240. The interplay between a galactic bar and a supermassive black hole: nuclear fuelling in a subparsec resolution galaxy simulation
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Emsellem, E., primary, Renaud, F., additional, Bournaud, F., additional, Elmegreen, B., additional, Combes, F., additional, and Gabor, J. M., additional
- Published
- 2014
- Full Text
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241. Performance of a Non Linear Dynamic Vibration Absorbers
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Djemal, F., primary, Chaari, F., additional, Dion, J.-L., additional, Renaud, F., additional, Tawfiq, I., additional, and Haddar, M., additional
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- 2014
- Full Text
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242. 'Anomalous' velocity dispersion in trabecular bone : influence of viscous absorption and of multiple scattering
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Haïat, G., Lhemery, A., Renaud, F., Padilla, F., Laugier, P., Naili, S., Laboratoire de Modélisation et Simulation Multi Echelle (MSME), Université Paris-Est Marne-la-Vallée (UPEM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Génétique et évolution des maladies infectieuses (GEMI), Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD [France-Sud]), Laboratoire de Modélisation et Simulation Multi Echelle ( MSME ), Université Paris-Est Marne-la-Vallée ( UPEM ) -Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ) -Centre National de la Recherche Scientifique ( CNRS ), Génétique et évolution des maladies infectieuses ( GEMI ), Centre National de la Recherche Scientifique ( CNRS ), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Université Paris-Est Marne-la-Vallée (UPEM), Haiat, Guillaume, and Université Montpellier 1 (UM1)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])
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[SPI.MECA.BIOM] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,[PHYS.MECA.BIOM] Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,[ SPI.MECA.BIOM ] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,[PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] ,ComputingMilieux_MISCELLANEOUS ,[ PHYS.MECA.BIOM ] Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] - Abstract
International audience
- Published
- 2009
243. Spread of Avian Influenza Viruses by Common Teal textit(Anas crecca) in Europe
- Author
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Lebarbenchon, Camille, Albespy, F., Brochet, A.L., Grandhomme, V., Renaud, F., Fritz, H., Green, A.J., Thomas, F., Van Der Werf, S., Aubry, P., Guillemain, M., Gauthier-Clerc, M., Ecologie quantitative et évolutive des communautés, Département écologie évolutive [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), and Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] - Published
- 2009
244. FGF1 nuclear translocation is required for its neurotrophic activity and for its p53-dependent apoptosis protection
- Author
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Rodriguez-Enfedaque, A., Bouleau, S., Laurent, M., Courtois, Y., Bernard Mignotte, Jl Vayssiere, Renaud, F., Laboratoire de génétique et biologie cellulaire (LGBC), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), and Begue, Angelique
- Subjects
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM] ,[SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM] ,ComputingMilieux_MISCELLANEOUS ,[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM] - Abstract
International audience
- Published
- 2009
245. Influence of multiple scattering and of absorption on the frequency dependence of phase velocity in trabecular bone
- Author
-
Haïat, G., Lhemery, F., Renaud, F., Padilla, F., Laugier, P., Naili, S., Laboratoire de Modélisation et Simulation Multi Echelle (MSME), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Université Paris-Est Marne-la-Vallée (UPEM), Génétique et évolution des maladies infectieuses (GEMI), Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD [France-Sud]), Laboratoire de Modélisation et Simulation Multi Echelle ( MSME ), Université Paris-Est Marne-la-Vallée ( UPEM ) -Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ) -Centre National de la Recherche Scientifique ( CNRS ), Génétique et évolution des maladies infectieuses ( GEMI ), Centre National de la Recherche Scientifique ( CNRS ), Université Paris-Est Marne-la-Vallée (UPEM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), and Haiat, Guillaume
- Subjects
[SPI.MECA.BIOM] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,[PHYS.MECA.BIOM] Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,[ SPI.MECA.BIOM ] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,[PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] ,ComputingMilieux_MISCELLANEOUS ,[ PHYS.MECA.BIOM ] Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] - Abstract
International audience
- Published
- 2008
246. Application Of Multi-Criteria Methodology For Planning An Electric Transmission Line
- Author
-
Armani, G. V., Roberto Benato, Di Mario, C., Lorenzoni, A., Rebolini, M., and Renaud, F.
- Published
- 2008
247. Application of Long High CapacityGas-Insulated Lines in Structures
- Author
-
Koch, H., Benato, Roberto, Laußegger, M., Köhler, M., Leung, K. K., Mirebeau, P., Kindersberger, J., Kunze, D., Di Mario, C., Renaud, F., and Bowmann, G.
- Published
- 2008
248. APPLICATION OF LONG HIGH CAPACITY GAS-INSULATED LINES IN STRUCTURES
- Author
-
Koch, H., Benato, Roberto, Laußegger, M., Köhler, M., Leung, K. K., Mirebeau, P., Kindersberger, J., Kunze, D., Di Mario, C., Renaud, F., and Bowmann, G.
- Published
- 2008
249. Sequence-specific Methyltransferase-Induced Labelling (SMILing) of plasmid DNA for studying cell transfection
- Author
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Schmidt, F., Hüben, M., Renaud, F., Teulade-Fichou, Marie-Paule, Weinhold, E., Conception, synthèse et vectorisation de biomolécules. (CSVB), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], and Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)
- Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry - Published
- 2008
250. A METHOD TO DETERMINE THE APPROPRIATE NETWORK MODEL FOR AN ON-LINE SECURITY ANALYSIS CALCULATION
- Author
-
Burri, P., primary, Renaud, F., additional, Chautems, A., additional, and Germond, A., additional
- Published
- 1984
- Full Text
- View/download PDF
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