201. Renal cell carcinomas with tubulopapillary architecture and oncocytic cells: Molecular analysis of 39 difficult tumors to classify
- Author
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Petr Grossmann, Kristyna Pivovarcikova, Veronika Hájková, Milan Hora, Michal Michal, Tomáš Pitra, Joanna Rogala, Ondrej Hes, Pavla Rotterova, Reza Alaghehbandan, Delia Perez Montiel, Peter Svajdler, Maryna Slisarenko, Adriena Bartos Vesela, Maris Sperga, and Kvetoslava Michalova
- Subjects
Adult ,Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,DNA Copy Number Variations ,Cell ,Pathology and Forensic Medicine ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Biomarkers, Tumor ,Genes, Overlapping ,medicine ,Adenoma, Oxyphilic ,Humans ,Oncocytoma ,Copy-number variation ,Diagnostic Errors ,Renal oncocytoma ,Carcinoma, Renal Cell ,In Situ Hybridization, Fluorescence ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Chromosome Aberrations ,Polysomy ,Kidney ,Oxyphil Cells ,Papillary renal cell carcinomas ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Kidney Neoplasms ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,Biopsy, Large-Core Needle ,business - Abstract
So-called oncocytic papillary renal cell carcinoma (OPRCC) is a poorly defined variant of papillary renal cell carcinoma. Since its first description, several studies were published with conflicting results, and thus precise definition is lacking. A cohort of 39 PRCCs composed of oncocytic cells were analyzed. Cases were divided into 3 groups based on copy number variation (CNV) pattern. The first group consisted of 23 cases with CNV equal to renal oncocytoma. The second group consisted of 7 cases with polysomy of chromosomes 7 and 17 and the last group of 9 cases included those with variable CNV. Epidemiologic, morphologic and immunohistochemical features varied among the groups. There were not any particular histomorphologic features correlating with any of the genetic subgroups. Further, a combination of morphologic, immunohistochemical, and molecular-genetic features did not allow to precisely predict biologic behavior. Owing to variable CNV pattern in OPRCC, strict adherence to morphology and immunohistochemical profile is recommended, particularly in limited samples (i.e., core biopsy). Applying CNV pattern as a part of a diagnostic algorithm can be potentially misleading. OPRCC is a highly variable group of tumors, which might be misdiagnosed as renal oncocytoma. Using the term OPRCC as a distinct diagnostic entity is, thanks to its high heterogeneity, questionable.
- Published
- 2021