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Copyright © 2020 IJEHSS - International Journal of Education Humanities and Social Science, Self-harm behaviors have been increasing systematically, particularly in adolescents. The national HBSC study evaluated the prevalence of self-harm behaviors and associated risk factors in Portuguese adolescents. The sample consisted of 5695 adolescents, of whom 46.1% were boys, with a mean age of 15 years. The results showed that 18% reported having experienced self-harm behavior. Regarding the risk factors associated with "self- harm", it was found that young people, with more symptoms, more depression, more unhappy, with lower quality of life, worse relationship with their parents and absence of family support were more likely to have engaged in self-harm behaviors.

Mestrado em Engenharia Alimentar - Qualidade e Segurança Alimentar - Instituto Superior de Agronomia The spoilage yeast, Brettanomyces bruxellensis, can cause the formation of film in storage wine, sediments, gas production and the production of unpleasant tastes and flavors to the consumer. Chitosan is presented as a potential product to control the yeast that alter the wine. Under laboratory conditions the effect of chitosan at different concentrations was tested in the growth of various B. bruxellensis strains in synthetic medium and wine. Viability was followed in plate with GYP medium, by hemocytometer counting with vital staining. Production of 4-ethylphenol was also analyzed. In synthetic medium it was possible to control the growth with 1 g/L of chitosan. In wine the necessary concentrations were lower, because it is a more stressful environment. With lower concentrations and with poorly adapted cells it was possible to control, the growth of the strains tested with 0,1 g/L and 0,05 g/L. However, when chitosan is added after the exponential phase, it is only possible to control the growth with 0,5 g/L. The production of 4-ethiphenol only reached significant values, over 800μg/L, on the wine trial with well adapted cells. The results in this trial show that the effect of chitosan is dependent of the strain, cellular concentration, growth stage of the cells and that the production of 4-ethylphenol was significant only in wine with well adapted cells. The usage of chitosan has no effect on the VBNC stage of the cells.

© Associação Brasileira do Sono, The academic years are a period of vulnerability when considering sleep problems and mental health. Growing evidence suggests poor sleep patterns are related to impaired academic life and lower psychological well-being. The aim of this study was to explore the importance of sleep habits and report the associations of sleep problems with quality of academic life and different dimensions of mental health (e.g. worries, anxiety, self-regulation and resilience) in a large sample of college students. The HBSC/JUnP data base comprises a representative sample of 2991 college students (n=2203; 73.7% women), aged from 18 to 35 years old (22.43±3.83). Participants socio-demographic characteristics included sex and age. Besides, participants were inquired about sleep duration, characteristics of their sleep habits, questions about quality academic life, namely feeling bored in university, pressure from academic work and academic performance perception and mental health, namely worries, anxiety, self-regulation and resilience. Results showed most young people report an average value for sleep habits (M=4.41; SD=1.46) and that they sleep an average of 7 hours a night. More than half of the young people report either being affected by difficulty falling asleep, showing signs of sleep onset insomnia (67.7%). The conducted analyses indicated that the difficulty falling asleep (having insomnia) was associated with poor/reasonable academic performance perception, higher levels of concerns and anxiety, and lower levels of self-regulation and resilience, thus jeopardizing the mental health of college students. In turn, that characteristics of sleep was also associated with poor sleep habits. In conclusion, this study showed that poor sleep habits were associated with a worse level of academic performance perception and low levels of mental health among college students in Portugal. Universities offer enormous potential as settings to promote sleep-health programs since they can reach many young people who are future-oriented and willing to learn. There is then the need for academic researchers, teaching staff and health professionals working for college students health, to develop and test a wide array of sleep-promoting interventions (e.g., education classes, online programs, adjustment of class time), thus preventing negative secondary outcomes.

A entrada na Universidade é uma época de transição, onde os jovens enfrentam novos desafios (pessoais, sociais e académicos) com impacto no seu estilo de vida. Utilizando o questionário HBSC da OMS na sua versão online, inquiriram-se 3345 estudantes do 10º ano, 12º ano e universitários, com uma média de idades de 15,9 anos (DP=0,68), 18,1 anos (DP=0,71) e 22,1 anos (DP=3,94), respetivamente. Os resultados obtidos sugerem diferentes perfis no que diz respeito ao risco e à proteção na transição da escola para o ensino superior. Apesar de existirem alguns comportamentos que têm uma evolução positiva com o aumento da idade e que podem ser protetores para a saúde; destacam-se os comportamentos com uma evolução negativa, como são os relacionados com os hábitos de sono, o consumo de substâncias psicoativas, e o não uso de preservativo, sobretudo no ano anterior à entrada no ensino superior; comprometendo consequentemente a saúde e o bemestar dos jovens. Esta investigação vem reforçar a necessidade de dar maior atenção aos comportamentos de saúde dos adolescentes na sua transição para a universidade, enfatiza a importância do papel das escolas secundárias e das universidades enquanto instituições promotoras de saúde, e demonstra a urgência do reforço das políticas públicas neste sentido., Admission to university is considered a time of transition, in which young people face new challenges (personal, social and academic) which may cause impact in their lifestyle. An online version of the questionnaire HBSC/WHO was administered to 3 345 students enrolled in 10th grade, 12th grade, and university, with an average age of 15.9 years (SD = 0.68), 18.1 years (SD = 0.71) and 22.1 years (SD = 3.94), respectively. Results suggest different profiles with regard to risk and protection in the transition from high school to university. Although there are some behaviors that follow a positive trend with the increase in age and that can be protective for health; the majority of behaviors follow a negative trend, such as those related to sleeping habits, consumption of psychoactive substances, and the lack of condom use, especially in the year before admission to university, thus compromising the health and well-being of young people. This research reinforces the need for greater attention to health behaviors of adolescents that are enrolling in university, emphasizes the importance of both high schools and universities as institutions that can promote health, and demonstrates the urgency of reinforcing public policies in this matter.

This investigation of the national HBSC study evaluated the prevalence of self-harm behaviors in Portuguese adolescents. Were included 5695 adolescents, of which 46.1% were boys, with a mean age of 15 years. Most of the adolescents are Portuguese (91.7%), 48.6% attend the 8th year, 30.0% the 10th year and 21.4% the 12th year. The measures included asking the adolescent whether he or she had already had self-harm behavior and which part of the body he injured. The results showed that 18.0% reported having self-harm behavior, in which more than one third reported performing self-harm behavior once to three times time in life, and more than one fifth of adolescents mentioned doing it 4 times or more. Younger adolescents more often mentioned performing this behavior. The most frequently used body area was the arms. These results could have significant implications as to providing information and customizing future education programs. In terms of prevention, it emphasizes the need to teach about this issue, because it is crucial for the promotion of mental health., Esta investigação do estudo nacional HBSC avaliou a prevalência dos comportamentos autolesivos nos adolescentes portugueses. Participaram 5695 adolescentes, dos quais 46,1% são rapazes, com uma média de idades de 15 anos. A maioria dos adolescentes são portugueses (91,7%), 48,6% frequentam o 8º ano, 30,0% o 10º ano e 21,4% o 12º ano. As medidas incluíam perguntar ao jovem se ele já teve comportamentos de autolesão e que parte do corpo lesionou. Os resultados mostraram que 18,0% relataram ter tido comportamento de autolesão, dos quais mais de um terço relatou realizar o comportamento autolesivo entre 1 a 3 vezes e mais de um quinto dos adolescentes mencionaram tê-lo feito 4 vezes ou mais. Adolescentes mais novos com mais frequência mencionaram realizar este comportamento. A área corporal mais frequentemente lesionada foi os braços. Estes resultados podem ter implicações significativas no direcionamento de futuros programas educacionais. Em termos de prevenção, enfatiza a necessidade de educar formalmente sobre esta questão, porquanto é crucial para a promoção da saúde mental., Marta Reis é apoiada pela Bolsa FCT (SFRH/BPD/110905/2015). Susana Gaspar é apoiada pela Bolsa da ULisboa (BD2016/609).

Dissertação de mestrado, Psicologia Social e das Organizações, Faculdade de Ciências Humanas e Sociais, Universidade do Algarve, 2014 Há muito que se estuda a questão da multiculturalidade e o peso que variáveis pessoais apresentam no estilo de gestão de conflito. Nos últimos anos, têm ocorrido fortes movimentos populacionais em Portugal, tanto ao nível da emigração como da imigração. Por outro lado, o mundo está mais global, devido a recursos da internet e a formas de mobilidade mais acessíveis, permitindo aos indivíduos vivenciar uma maior experiência multicultural. O aumento destas interações potencia o aparecimento do conflito. Alguns estudos exploraram a relação entre a inteligência cultural, o self-interdependente e o self-monitoramento e os estilos de gestão de conflito, contudo esta relação continua pouco clara. O nosso objetivo consiste em testar um modelo que sugere que elevados níveis de inteligência cultural mediados por um elevado self-interdependente e self-monitoramento afetam positivamente e predizem a tendência que um individuo possui para utilizar estilos de resolução de conflito adequados ao background cultural daqueles envolvidos no conflito. Procurámos, ainda, compreender de que forma a quantidade e a qualidade de contacto multicultural afetam a Inteligência Cultural. Trezentos e noventa e nove participantes responderam aos instrumentos por via online. Os resultados demonstram que, o self-interdependente apresenta uma maior influência na inteligência cultural em vez da quantidade e qualidade do contacto, e o self-monitoramento apresenta um peso significativo na dimensão de estilo de conflito Dominação. Implicações práticas e teóricas são discutidas.

Silva, A.M.; Carnim, G.; Isidoro, J.; Reis, M.; Matos, V.; Marques, A.C. 2001. A necrópole do século XVI instalada na Villa romana do Rabaçal. In: M. Pessoa; L. Rodrigo; S. Santos (Eds.). Roteiro: Rabaçal - Aldeia Cultural. Penela: Câmara Municipal de Penela, pp. 20-22. ISBN: 972-97881-1-1

© 2016 Apex Journal International, A self-administered questionnaire was carried out among university students in Portugal, with the aim to have better knowledge of students’ (a) sexual behaviours and contraception use and identify trajectories that lead to pregnancy or voluntary interruption of pregnancy (VIP). The study provided national representative data of 3.278 university students in Portugal, between 18 and 35 years old. The sample included 70% women and 30% men. The mean age was 21 years old. The majority of students are Portuguese, single, catholic, heterosexual and have had sexual intercourse. The majority had their first sexual intercourse at the age of 16 or later, used condom as their first contraceptive method and usually used the pill and condom. Concerning unintended pregnancies and abortions, it was found that a minority of students reported having had at least one of them. Therefore, there was a minority, but worthy of concern, group of students at risk, which may suggest that protective behaviours are not consistent or they are abandoned over time. Based on this study and its results, inconsistent contraceptive use is identified. Nine trajectories were identified; seven of which leading to pregnancy or VIP. Findings from the current research have practical implications for both contraceptive education and STI prevention among college students. University students in particular face new challenges in sexual health and need more comprehensive education aimed at promoting healthy decision-making about family planning and STI prevention., The first author has a grant supported by the Foundation for Science and Technology (SFRH/BPD/110905/2015).

Libro de Resumos da II Xuntanza de Investigador@s Nov@s no ámbito da química (XINQ_2). A XINQ é un espazo de encontro no que as investigadoras e investigadores novos que desenvolven o seu traballo no ámbito da química poden dalo a coñecer ao resto da comunidade universitaria, e potenciar ao tempo as súas capacidades de comunicación en público en lingua galega. Isto desenvólvese a través de sesións abertas de comunicacións orais nas que esta mocidade investigadora presenta, en lingua galega e cun enfoque divulgativo, algúns aspectos máis ou menos específicos do traballo que realiza ou da súa área de investigación. Nesta segunda edición, a XINQ presentou como maior novidade a concesión de premios ás mellores comunicacións nas modalidades de máster e de doutoramento, segundo a valoración dos comités organizador e científico, e a do público asistente.

Submitted by Mariangela CEH/A (marianfig@gmail.com) on 2021-09-16T17:16:03Z No. of bitstreams: 2 Dissertação - Emília Delesderrier Franco - 2019 - Completa.pdf: 1334406 bytes, checksum: 7668f906374d577cb8d82fd2fdeabf1c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Made available in DSpace on 2021-09-16T17:16:03Z (GMT). No. of bitstreams: 2 Dissertação - Emília Delesderrier Franco - 2019 - Completa.pdf: 1334406 bytes, checksum: 7668f906374d577cb8d82fd2fdeabf1c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2019-06-20 Sickle cell disease is characterized by the presence of sickle cells in the blood, due to deoxygenation of hemoglobin. The effects of falcization, such as intravascular hemolysis and vaso-occlusion with ischemia-reperfusion injury, occur cyclically and trigger excessive production of reactive oxygen species. The increase of these reactive species can result in depletion of the antioxidant systems and cause oxidative imbalance intra and extracellular. In this way, it is possible to induce the instability of membranes of red blood cells, contributing to the increase of hemolysis. The main objective of the present study was to evaluate the relationship between plasma concentrations of antioxidant micronutrients (retinol, α-tocopherol, selenium and zinc) with hemolysis and inflammation indicators in individuals with sickle cell disease. The study consisted of 51 adults with sickle cell disease, who were followed up at two Reference Centers in Hematology in the State of Rio de Janeiro. Serum concentrations of vitamins were determined by high performance liquid chromatography and minerals by atomic absorption spectrometry. The markers of hemolysis by automatic analyzer, and those of inflammation by nephelometry. For the statistical analysis, multivariate linear regression models were used, using SPSS® software.Most patients presented selenium deficiency and consumption. Linear regression analysis showed that selenium is the main determinant of hemolysis among the antioxidant nutrients analyzed. Thus, data from this study suggest that the nutritional care protocols for patients with SCD should include dietary sources of selenium in order to reduce the risk of hemolysis A doença falciforme caracteriza-se pela presença de hemácias falcizadas no sangue, em decorrência da desoxigenação da hemoglobina. Os efeitos da falcização, como a hemólise intravascular e a vaso-oclusão com lesão de isquemia-reperfusão, ocorrem de forma cíclica e desencadeiam produção excessiva de espécies reativas de oxigênio. O aumento destas espécies reativas pode resultar em depleção dos sistemas antioxidantes e causar desequilíbrio oxidativointra e extracelular. Desta forma, pode-se induzir à instabilidade de membranas de hemácias, contribuindo para o aumento da hemólise. O principal objetivo do presente estudo foi avaliar a relação entre as concentrações plasmáticas de micronutrientes antioxidantes (retinol, α-tocoferol, selênio e zinco) com indicadores de hemólise e de inflamação em indivíduos com doença falciforme. Partificaparam51 adultos com doença falciforme, acompanhados em dois Centros de Referência em Hematologia do Estado do Rio de Janeiro. As concentrações séricas das vitaminas foram determinadas por cromatografia líquida de alta eficiência e a dos minerais por espectrometria de absorção atômica. Os marcadores de hemólise por analisador automático, e os de inflamação por nefelometria. Para a análise estatística foram utilizados modelos de regressão linear multivariada, por meio do software SPSS®. A maioria dos pacientes apresentou deficiencia de selênio sérico. A análise de regressão linear demostrou que o selênio foi o principal determinante da hemólise, dentre os nutrientes antioxidantes analisados. Dessa forma, os dados desse estudo sugerem que deve ser incluído fontes dietéticas de selênio nos protocolos de cuidado nutricional para pacientes com doença falciforme, a fim de reduzir o risco de hemólise nesses indivíduos

Submitted by Boris Flegr (boris@uerj.br) on 2021-01-06T20:57:19Z No. of bitstreams: 1 Matheus Henrique Romao Dissertacao completa.pdf: 1860600 bytes, checksum: cde66f9a8ad7c8d61919f96eb0052b88 (MD5) Made available in DSpace on 2021-01-06T20:57:19Z (GMT). No. of bitstreams: 1 Matheus Henrique Romao Dissertacao completa.pdf: 1860600 bytes, checksum: cde66f9a8ad7c8d61919f96eb0052b88 (MD5) Previous issue date: 2019-02-18 Conselho Nacional de Desenvolvimento Científico e Tecnológico Obesity is associated with the development of several metabolic alterations, such as hypertension. The elevation of the renin angiotensin system (RAS) observed in obesity is related to the development of insulin resistance, which can lead to hepatic steatosis, which is the accumulation of fat in the liver. Previous studies have demonstrated that the hydroalcoholic extract of the açaí stone (ASE) acts in an experimental model of obesity, preventing hypertension, dyslipidemia, weight gain and hyperglycemia. In addition to these effects, ASE demonstrated in the renovascular hypertension model the ability to modulate RAS components, reducing plasma renin levels. The aim of this study was to evaluate the preventive effect of ASE treatment on hepatic alterations in an obesity animal model, comparing it with the effects of RAS inhibitors: enalapril (ENA) and telmisartan (TEL). 30 day old male C57BL / 6 mice were separated into five control groups (diet 10% lipids); HF (60% lipid diet); HF + ASE (300 mg / kg-1), HF + ENA (30 mg / kg-1) and HF + TEL (10 mg / kg-1). The diet was administered concomitantly with these treatments, which were performed by intragastric gavage for 12 weeks. Body mass and glycemia were evaluated during the treatment period. At the end of treatment and after euthanasia, liver weight, visceral adipose tissue weight, Lee index, caloric intake, liver lipid profile, antioxidant enzyme activity and oxidative damage in liver homogenate were evaluated. In addition, the protein expression of the components of the RAS and factor NF-kB was evaluated by western blotting in liver homogenate. Hepatic steatosis was evaluated histologically. In the HF group there was an increase in body weight and blood glucose, changes that were prevented by the treatment with ASE and ENA. The HF group also showed an increase in visceral adipose tissue weight, caloric intake and Lee's index. Treatment with ASE prevented the increase of adipose tissue weight and Lee's index, treatment with ENA prevented all these increases and the TEL was not able to prevent these changes. All treatments prevented the increase of hepatic levels of cholesterol and triglycerides observed in the HF group. Increased liver weight and steatosis were prevented by ASE and ENA treatments. All treatments prevented the reduction of the antioxidant activity observed in the HF group. The HF group showed increased expression of renin and AT1. All treatments decreased renin expression, only treatment with TEL decreased AT1 expression. Treatment with ASE increased the expression of ECA-2 and Mas. These results indicate that the ASE prevented the deleterious effects of the HF diet on the liver and could be effective compared to the ENA. The beneficial effects of ASE involve the reduction of weight gain, the antioxidant effect and also the modulation of RAS, proving to be an important tool in the treatment of hepatic steatosis A obesidade está associada ao desenvolvimento de diversas alterações metabólicas. A elevação do Sistema renina-angiotensina (SRA) observada na obesidade se relaciona o desenvolvimento da resistência insulínica, que por sua vez pode levar a esteatose hepática, que é o acúmulo de gordura no fígado. Estudos prévios demonstram que o extrato hidroalcoólico do caroço do açaí (ASE) atua em modelo experimental de obesidade prevenindo a hipertensão arterial, dislipidemia, ganho de peso e hiperglicemia. Além destes efeitos, o ASE demonstrou em modelo de hipertensão renovascular a capacidade de modular componentes do SRA, reduzindo os níveis de renina plasmática. Sendo assim, buscou-se avaliar o efeito preventivo do tratamento com o ASE sobre as alterações hepáticas em modelo animal de obesidade, comparando-o com os efeitos de fármacos inibidores do SRA: enalapril (ENA) e o telmisartan (TEL). Camundongos machos C57BL/6 com 30 dias de idade foram separados em cinco grupos: controle (dieta 10% lipídeos); HF (dieta 60% lipídeos); HF+ASE (300 mg/kg-1), HF+ENA (30 mg/kg-1) e HF+TEL (10 mg/kg-1). A dieta foi administrada concomitantemente com estes tratamentos, os quais foram realizados por gavagem intragástrica durante 12 semanas. A massa corporal e a glicemia foram avaliadas durante o período de tratamento. Ao fim do tratamento e posteriormente à eutanásia foram avaliados o peso do fígado, o peso do tecido adiposo visceral, o índice de Lee, o consumo calórico, o perfil lipídico hepático, a atividade das enzimas antioxidantes e o dano oxidativo em homogenato de fígado. Além disso, a expressão proteica dos componentes do SRA e do fator NF-kB foi avaliada por western blotting em homogenato de fígado. A esteatose hepática foi avaliada histologicamente. No grupo HF houve um aumento do peso corporal e da glicemia, alterações que foram prevenidas pelo tratamento com ASE e ENA. O grupo HF também apresentou um aumento do peso do tecido adiposo visceral, do consumo calórico e do índice de Lee. O tratamento com ASE preveniu o aumento do peso do tecido adiposo e do índice de Lee, o tratamento com ENA preveniu todos estes aumentos e o TEL não foi capaz de prevenir essas alterações. Todos os tratamentos preveniram o aumento dos níveis hepáticos de colesterol e triglicerídeos observados no grupo HF. O aumento do peso do fígado e a esteatose foram prevenidos pelos tratamentos com ASE e ENA. Todos os tratamentos preveniram a redução da atividade antioxidante observada no grupo HF. O grupo HF apresentou expressão aumentada de renina e AT1. Todos os tratamentos diminuíram a expressão de renina, somente o tratamento com TEL diminuiu a expressão de AT1. O tratamento com ASE aumentou a expressão de ECA-2 e Mas. Estes resultados indicam que o ASE preveniu os efeitos deletérios da dieta HF sobre o fígado, podendo ter sua eficácia comparada ao ENA. Os efeitos benéficos do ASE envolvem a redução do ganho de peso, o efeito antioxidante e também a modulação do SRA, demonstrando-se uma ferramenta importante no tratamento da esteatose hepática.

Submitted by Boris INFORMAT (boris@uerj.br) on 2021-04-26T01:14:53Z No. of bitstreams: 1 Thamiris de Souza Dissertacao completa.pdf: 1295645 bytes, checksum: d02a9de8958dab35057294925d09e4ab (MD5) Made available in DSpace on 2021-04-26T01:14:53Z (GMT). No. of bitstreams: 1 Thamiris de Souza Dissertacao completa.pdf: 1295645 bytes, checksum: d02a9de8958dab35057294925d09e4ab (MD5) Previous issue date: 2017-07-26 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Functional changes in different types of adipose tissue are commonly present in obesity and have been referred as remodeling. Some fatty acids, such as polyunsaturated omega-3, were related to the consequences of obesity. The objective of the present study was to evaluate the effect of dietary supplementation with chia (Salvia hispanica L.) oil on the subcutaneous and visceral adipose tissue of obese animals at different stages of life. Male Swiss mice were divided into 4 groups at 21 days of age, fed diets up to 135 days: EU: control diet; H: high fat diet (45% Kcal of lipids); HC: animals of group H with supplementation of chia oil from 90 days; HCD:high fat diet with chia oil supplementation since weaning. Glucose tolerance; inflammatory markers; morphometry of epididymal adipose tissue; expression of genes and proteins involved in the remodeling of adipose tissue by qRT-PCR, western blotting and immunohistochemistry were evaluated. Chia oil supplementation caused changes in both groups. In HCD, food intake and serum leptin concentrations were reduced. In epididymal adipose tissue, supplementation promoted less adipocyte hypertrophy. In addition, it resulted in improved glycemic response and animals from the HCD group increased the mitochondrial load markers in the subcutaneous adipose tissue, suggesting the browning process. Obesity and supplementation did not promote changes related to angiogenesis or the presence of macrophages in epididymal adipose tissue. Thus, the results suggest that supplementation with chia oil may minimize the changes caused by obesity, mainly in the HCD group. Alterações funcionais nos diferentes tipos de tecido adiposo estão comumente presentes na obesidade e têm sido referidas como remodelamento. Alguns ácidos graxos, como poliinsaturados ômega-3, foram relacionados às consequências da obesidade. O objetivo do presente estudo foi avaliar o efeito da suplementação dietética com óleo de chia (Salvia hispanica L.) no tecido adiposo subcutâneo e visceral de animais obesos em diferentes fases da vida. Camundongos machos Swiss foram divididos em 4 grupos aos 21 dias de idade, sendo alimentados com as dietas até os 135 dias: EU: dieta controle; H: dieta hiperlipídica(45% Kcal de lipídeos); HC: animais do grupo H com suplementação do óleo de chia a partir dos 90 dias; HCDdieta hiperlipídica com suplementação desde o desmame. Foram avaliados tolerância à glicose; marcadores inflamatórios; morfometria do tecido adiposo epididimal; expressão de genes e proteínas envolvidos no remodelamento de tecido adiposo por qRT-PCR, western blotting e imunohistoquímica. A suplementação com óleo de chia ocasionou alterações em ambos os grupos. No HCD, a ingestão alimentar e a concentração sérica de leptina foram reduzidas. No tecido adiposo epididimal, a suplementação promoveu menor hipertrofia dos adipócitos. Além disso, resultou na melhorada resposta glicêmica e os animais do grupo HCD aumentaram os marcadores de carga mitocondrial no tecido adiposo subcutâneo, sugerindo a ocorrência do processo de browning. A obesidade e a suplementação não promoveram mudanças relacionadas à angiogênese ou à presença de macrófagos no tecido adiposo epididimal. Dessa forma, os resultados sugerem que a suplementação com óleo de chia pode minimizar as alterações causadas pela obesidade, principalmente no grupo HCD.

Tese de mestrado, Saúde do Adolescente, Universidade de Lisboa, Faculdade de Medicina, 2017 Submitted by Fernando João Machado (fjmachado@fm.ul.pt) on 2018-06-20T14:38:41Z No. of bitstreams: 1 11583_Tese.pdf: 1468959 bytes, checksum: a800d00e7fc39fab29147b2eea3fb5b6 (MD5) Made available in DSpace on 2018-06-20T14:38:51Z (GMT). No. of bitstreams: 1 11583_Tese.pdf: 1468959 bytes, checksum: a800d00e7fc39fab29147b2eea3fb5b6 (MD5) Previous issue date: 2017

Submitted by Boris Flegr (boris@uerj.br) on 2021-01-05T16:44:21Z No. of bitstreams: 1 Dissert_Juliana Omena Braga de Mendonca.pdf: 643132 bytes, checksum: e96fc78c2f89a445bb95cb0a9951466f (MD5) Made available in DSpace on 2021-01-05T16:44:21Z (GMT). No. of bitstreams: 1 Dissert_Juliana Omena Braga de Mendonca.pdf: 643132 bytes, checksum: e96fc78c2f89a445bb95cb0a9951466f (MD5) Previous issue date: 2016-07-22 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Introduction: Sickle cell disease (SCD) is a type of hemoglobinopathy characterized by inflammation and chronic hemolysis. Intense erythropoiesis and inherent anemia may suggest that hepcidin reduction, which is the key regulator of iron metabolism, may result in increased iron absorption. In contrast, inflammatory condition and the iron overload due to chronic blood transfusions experienced by sickle cell patients would be able to induce the transcription of this hormone, leading to reduced absorption of this micronutrient. The lack of knowledge about hepcidin behavior on SCD impairs the development of a specific nutritional protocol for these people. The aim of this study was to evaluate the hepcidin behavior in people with SCD. Methods: Cross-sectional study with 115 adults divided into groups with SCD and iron overload (n=13; 41.0±11.6 years); SCD without iron burden (n=59; 30.9±10.7); and adults without SCD (n=43; 29.4±8.9). Blood samples were collected for evaluation of the following parameters: hematocrit, hemoglobin, hemoglobin S and fetal, serum hepcidin, ferritin, serum iron, total iron-binding capacity (TIBC) and lactate dehydrogenase (LDH). Results: Hepcidin was significantly higher in subjects with SCD with iron overload than SCD without iron burden group (12.0 ng/mL versus 4.2 ng/mL, respectively) and adults without SCD (12.0 ng/mL versus 7.2 ng/mL, respectively). In contrast, patients with SCD without iron burden has presented lower hepcidin concentration than other groups. Except in the SCD with iron overload group, ferritin was strong and positively correlated with serum hepcidin, appearing also as the main variable able to influence the variation of hepcidin levels; hemoglobin S, LDH, female gender and age also appear as variables able to influence the variability of this hormone, but with less intensity. Conclusion: Serum hepcidin is increased in individuals with SCD and iron overload, suggesting that high hepcidin concentration could decrease the iron absorption and, therefore, it would not be necessary to restrict iron rich foods from the diets of SCD individuals Introdução: A doença falciforme (DF) é uma hemoglobinopatia caracterizada por inflamação e hemólise crônicas. A intensa eritropoiese e anemia inerentes à doença são fatores que potencialmente ocasionariam a redução da produção de hepcidina hormônio responsável pela homeostase de ferro acarretando o aumento da absorção intestinal deste micronutriente. Em contrapartida, o quadro inflamatório característico, bem como a sobrecarga de ferro observada em alguns pacientes, seriam capazes de induzir a transcrição deste hormônio, reduzindo a absorção de ferro. A lacuna no conhecimento a respeito do comportamento da hepcidina gera dificuldades para a elaboração de um protocolo nutricional específico para estas pessoas. Assim, o objetivo deste trabalho foi avaliar o comportamento da hepcidina sérica em indivíduos com doença falciforme. Métodos: Estudo transversal realizado com 115 adultos, divididos nos grupos com DF e presença de sobrecarga de ferro (n=13; 41,0 ±11,6 anos); com DF sem sobrecarga (n=59; 30,9±10,7 anos); e indivíduos sem a doença (n=43; 29,4±8,9 anos). Amostras de sangue foram coletadas para a avaliação dos seguintes parâmetros: hematócrito, hemoglobina, hemoglobinas S e fetal, hepcidina sérica, ferritina, ferro sérico, capacidade total de ligação de ferro (CTLF) e lactato desidrogenase (LDH). Resultados: A concentração de hepcidina sérica apresentou-se significativamente maior nos participantes com doença falciforme e sobrecarga de ferro em relação ao grupo com DF sem sobrecarga (12,0 ng/mL versus 4,2 ng/mL, respectivamente) e também ao grupo sem a referida doença (12,0 ng/mL versus 7,2 ng/mL, respectivamente). Em contrapartida, o grupo com DF sem sobrecarga de ferro apresentou menores concentrações de hepcidina sérica se comparado aos outros grupos estudados. Exceto no grupo com DF e sobrecarga de ferro, a ferritina correlacionou-se fortemente com a hepcidina, apresentando-se também como a principal variável capaz de influenciar na variabilidade deste hormônio nos demais grupos; hemoglobina S, LDH, sexo feminino e idade também apareceram como variáveis capazes de influenciar na variabilidade da concentração de hepcidina, porém com menor intensidade. Conclusão: A hepcidina sérica apresentou-se elevada nos indivíduos com doença falciforme e sobrecarga de ferro, sugerindo que o aumento da concentração deste hormônio poderia diminuir a absorção deste micronutriente, não havendo, então, a necessidade de restrição de alimentos ricos em ferro neste grupo

Submitted by Boris Flegr (boris@uerj.br) on 2021-01-05T16:43:02Z No. of bitstreams: 1 Dissert_Thaisa Mattos.pdf: 1147784 bytes, checksum: 79902cb24e8fe6730c0a2ae4a6e3436b (MD5) Made available in DSpace on 2021-01-05T16:43:02Z (GMT). No. of bitstreams: 1 Dissert_Thaisa Mattos.pdf: 1147784 bytes, checksum: 79902cb24e8fe6730c0a2ae4a6e3436b (MD5) Previous issue date: 2015-07-30 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior High plasma concentrations of leptin have been related to increased formation of reactive oxygen species (ROS) that can play a central regulatory role in inflammatory and cardiovascular events. Recent studies have shown that vitamin D is able to reduce oxidative stress markers, as well as interfere with the production of inflammatory cytokines. The aim of this study was to evaluate the effect of pre-treatment with physiological (10-10 M) and supraphysiological (10-7 M) concentrations of 1,25(OH)2D3 in the production of superoxide anion (O2) and transcription factors NF-κB and Nrf2 in human endothelial cells stimulated with different leptin concentrations (1 and 10 ng/mL). When cells were pre-treated with 1,25(OH)2D3, and were stimulated with leptin (1 and 10 ng/mL), 1,25(OH)2D3 reduced (p

Submitted by Boris Flegr (boris@uerj.br) on 2021-01-05T16:44:20Z No. of bitstreams: 1 Dissert_Carolyne Pimentel Rosado.pdf: 692059 bytes, checksum: 4f80ddbc58174730d801dc96131af9ff (MD5) Made available in DSpace on 2021-01-05T16:44:20Z (GMT). No. of bitstreams: 1 Dissert_Carolyne Pimentel Rosado.pdf: 692059 bytes, checksum: 4f80ddbc58174730d801dc96131af9ff (MD5) Previous issue date: 2015-07-22 Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro The boiled green banana pulp mass (Musa spp.) is a food matrix that has been arousing interest in the domestic market by reason of its low technological sophistication and its benefits to the human health, mainly due to the presence of bioactive compounds and resistant starch. Besides, the development of a food product derived from green bananas appears as a sustainable approach to minimize the waste of the fruit. In spite of its economical, social and physiological importance, the boiled green banana pulp mass (GBPm) has been scarcely investigated. The aim of this study was to determine and compare the chemical composition and functional properties of GBPm from the three most consumed cultivars in Brazil: Nanica (Musa cavendishii, AAA group), Nanicão (Musa cavendishii, AAA group) and Prata (Musa sapientum, AAB group). The degree of maturation of green bananas was determined by colorimetric analysis through a digital colorimeter. The chemical parameters - titratable acidity (TA), pH, moisture, ash, fat, protein, total carbohydrates, dietary fiber (DF) and its fractions, resistant starch (RS), total carotenoids (TC), lutein, α-carotene, β-carotene and cis isomers - and the functional properties - water-holding capacity (WHC) and oil retention capacity (ORC) - of GBPm were determined by validated methods, and the results of the three cultivars were compared. The comparison was conducted by one-way ANOVA with Tukey post-test, using the software SPSS 17.0 3.5. Regarding the chemical composition, the lipid content was not statistically different among cultivars (0.2 to 0.4%), while water contents (74.8 to 79.6%), ash (2.6 to 3.3%), protein (4.6 to 5.7%) and carbohydrates (90.9 to 92.0%) varied statistically (p ≤ 0.05). There was no statistical difference between the TA values, in % of malic acid (average 0.2 ± 0.03), pH (4.7 to 4.8), WHC (1.6 to 1.8 g of water / g of GBPm) and ORC (0.5 to 0.7 g of oil / g of GBPm). The GBPm of Nanica and Nanicão showed higher RS contents (66.2 ± 11.5 and 65.9 ± 5.7 %, respectively; p = 0.346) than Prata (51.6 ± 5.8%; p = 0.001). The DF content was below 3% of the product (wet basis) in the GBPm of the three cultivars, therefore, it cannot be considered as source of this food component. It was observed a high content of indigestible carbohydrates in the GBPm of the three cultivars, justifying the low caloric value of matrices (16-38 kcal; on a wet basis). The GBPm of Nanica and Nanicão cultivars showed, respectively, higher concentrations of TC (16.4 ± 0.23 and 13.3 ± 0.31 µg/g), lutein (1.1 ± 0.06 and 1.3 ± 0.14 µg/g), α-carotene (4.8 ± 0.06 and 4.1 ± 0.04 µg/g), β-carotene (5.7 ± 0.04 and 4.2 ± 0.01 µg/g), 13-cis-β-carotene (1.3 ± 0.01 and 1.0 ± 0.03 µg/g) and 9-cis-β-carotene (0.4 ± 0.03 and 0.3 ± 0.0 µg/g), than the Prata cultivar (4.7 ± 0.14 µg/g, 0.8 ± 0.06 µg/g, 1.1 ± 0.01 µg/g, 1.5 ± 0.01 µg/g, 0.3 ± 0.0 µg/g and 0.2 ± 0.02 µg/g, respectively). When comparing the equivalent retinol values of GBPm with other foods of plant origin, it was observed lower levels of these compounds in the three cultivars. Thus, this food matrix is not a natural source of provitamin A. The GBPm of Nanica and Nanicão are the most interesting raw materials from a nutritional and functional point of view due to the high concentration of RS A massa de polpa de banana verde (Musa spp.) cozida é uma matriz alimentar que vem despertando interesse no mercado nacional devido à sua baixa sofisticação tecnológica e seus benefícios à saúde humana, principalmente devido à presença de compostos bioativos e amido resistente. Além disso, o desenvolvimento de um produto alimentício oriundo da banana verde surge como uma abordagem sustentável para minimizar o desperdício do fruto. Apesar da sua importância econômica, social e fisiológica, a massa de polpa de banana verde cozida (PBVm) tem sido pouco investigada. O objetivo do presente estudo foi determinar e comparar a composição química e as propriedades funcionais, das PBVm obtidas a partir dos três cultivares mais consumidos no Brasil: Nanica (Musa cavendishii, grupo AAA), Nanicão (Musa cavendishii, grupo AAA) e Prata (Musa sapientum, grupo AAB). O grau de maturação das bananas verdes foi verificado por análise colorimétrica através do colorímetro digital. Os parâmetros químicos - acidez titulável (AT), pH, umidade, cinzas, lipídios, proteínas, carboidratos totais, fibras dietéticas (FD) e suas frações, amido resistente (AR), carotenoides totais (CT), luteína, α-caroteno, β-caroteno e cis-isômeros - e as propriedades funcionais - capacidade de retenção de água (CRA) e capacidade de retenção de óleo (CRO) - das PBVm foram determinados por metodologias validadas, e os resultados dos três cultivares foram comparados. A comparação entre as variedades foi realizada por ANOVA one-way com post-teste de Tukey. Em relação à composição centesimal, não foi observada diferença entre os teores, em base seca, de lipídios (0,2 a 0,4%), enquanto os valores de cinzas (2,6 a 3,3%), proteínas (4,6 a 5,7%) e carboidratos (90,9 a 92,0%) variaram (p

Relatório de estágio realizado no âmbito do mestrado em Psicologia Clínica, Universidade Lusíada de Lisboa, 2015. Exame público realizado em 30 de Novembro de 2015. O presente relatório final descreve a experiência de um estágio curricular realizado no Projeto Aventura Social. Este estágio foi complementado pelo acompanhamento psicológico e individual de casos clínicos, através da psicoterapia de apoio e aconselhamento, tendo por base o modelo cognitivo-comportamental na terapêutica de problemáticas relacionadas com a baixa autoestima e desmotivação em diversas faixas etárias. Reúne ainda, uma intervenção ao nível da promoção de saúde da alimentação saudável e um projeto de investigação sobre a temática mais abordada desde os anos setenta, a homossexualidade e homoparentalidade.

Submitted by Boris Flegr (boris@uerj.br) on 2021-01-05T16:43:49Z No. of bitstreams: 1 Dissert_Pilar Silva Raphael Mataratzis.pdf: 2840713 bytes, checksum: 90ce61a504f31c4718e20a7aee79e396 (MD5) Made available in DSpace on 2021-01-05T16:43:49Z (GMT). No. of bitstreams: 1 Dissert_Pilar Silva Raphael Mataratzis.pdf: 2840713 bytes, checksum: 90ce61a504f31c4718e20a7aee79e396 (MD5) Previous issue date: 2013-10-31 Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro Sickle cell disease (SCD) is the most common hereditary disorder in Brazil and in the world and is characterized by the presence of S hemoglobin in homozigosis. Chronic hemolytic anemia and vaso-occlusion commonly occur and probably contribute to impairment of nutritional status which, in turn, are frequently accompanied by changes in body composition and delayed skeletal maturation. The aim of the present study was to compare nutritional status and bone mass in 2 to 5 years children with and without sickle cell disease. Nutritional status was evaluated by using the following indices: body mass index for age (BMI/age), weight for age (W/A), height for age (H/A) and weight for height (W/H) evaluated as z-scores and adequacies for midupper arm circumference (MUAC), triciptal skinfold thickness (TST) and upper arm muscle circumference (UAMC). Laboratorial analyses included hemoglobin, hematocrit, reticulocyte count, lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), serum iron and transferrin. Bone age was assessed by a left hand and wrist radiograph and bone mass was evaluated by dual energy X-ray absorptiometry (DXA). Fifty two children with SCD and 47 control children were enrolled. In the group of SCD children, considering BMI/age, the prevalence of overweight (7,7% overweight risk and 3,9% overweight) was higher than the prevalence of under nutrition (1,9%). It was observed a higher prevalence of height deficit (13,5%) than weight deficit (3,9%) in the SCD children. Body composition results from DXA showed that total body mass, body fat and percent of body fat were significantly higher in the control group than in the group with SCD (p < 0,001). Based on relative bone age, deficits in skeletal maturation were significantly higher (p