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Objetivo: Determinar os benefícios da aplicação das bandas neuromusculares na reabilitação do pé nos doentes pós acidente vascular cerebral. Metodologia: Estudo de revisão sistemática da literatura segundo o modelo de Joanna Briggs Institute. Incluíram‐se estudos em adultos pós acidente vascular cerebral aos quais foram aplicadas bandas neuromusculares. Cinco revisores independentes realizaram a avaliação critica, extração e síntese dos dados. Apresentação e interpretação dos resultados: Os 4 estudos incluídos reportaram melhorias na postura corporal, deambulação e perceção sensorial. Conclusão: Os estudos analisados sugerem que as bandas neuromusculares podem ser um método promissor a ser utilizado como método complementar no tratamento do pé do doente pós acidente vascular cerebral, sendo que são necessários mais estudos neste âmbito. Palavras-chave: acidente vascular cerebral, bandas neuromusculares, Kinesio Taping, pé, reabilitação

Este estudo tem como objetivo descrever o perfil epidemiológico dos pacientes coinfectados por HTLV-1 e Strongyloides stercoralis, oriundos do Núcleo de Medicina Tropical (NMT) localizado na Universidade Federal do Pará (UFPA). Foi realizada uma análise quantitativa, retrospectiva e transversal, na qual foram utilizadas informações de pacientes com sorologia positiva para HTLV, confirmada pela Reação em Cadeia da Polimerase (PCR) para HTLV-1 ou HTLV-2, além de exames parasitológicos confirmados pelo método de Hoffman. Dos 4.679 pacientes examinados foram detectadas 538 amostras positivas, sendo 432 para HTLV-1 (80%) e 106 para HTLV-2 (20%). No exame parasitológico foram obtidas 14 amostras positivas para o S. stercoralis e 81 negativas de um total de 95 pacientes que levaram seu material para a análise, onde foi possível determinar uma prevalência de coinfecção de 14,7% entre os dois agentes infecciosos. Observou-se um predomínio de pacientes positivos para HTLV-1 do sexo feminino em relação ao masculino. Isso pode ocorrer devido à facilidade da transmissão através da relação sexual e também pelos efeitos hormonais das mulheres, deixando-as mais suscetíveis à infeção. A partir disso, verificou-se que pacientes com HTLV-1/2 podem também apresentar coinfecção com S. Stercoralis, sobretudo no estado do Pará.

This study aimed to bioprospect and select halotolerantes bacteria and promoting plant growth associated with the plant Atriplex nummularia L. in saline soils. For bioprospecting of bacteria, samples were collected in five niches and two field experiments located in Serra Talhada and Ibimirim, Pernambuco, Brazil. After collecting the material it was performed the isolation and selection of bacteria based on plant growth promotion mechanisms. 107 bacterial salt tolerant isolates were obtained in which the population density of bacteria was higher in the rhizosphere (107 CFU g-1 soil), the cultivated soil (106 CFU g-1 soil) and uncultivated soil (105 CFU g-1 soil). For the solubilization rate of inorganic phosphate was obtained 65 and 25% positives isolated in 0 to 5% NaCl concentration, respectively. For the characteristics of biological fixation nitrogen, indole acetic acid production, exopolysaccharides and quorum sensing molecule, reached up to 87 percent; 100; 83.33 and 96.66% of the bacteria, respectively. Therefore, the bacterial isolates UAGAt 89 and UAGAt 101 expressed greater tolerance to salinity when analyzed in relation to the characteristics that promote plant growth, making it promising for future studies in order to contribute to the development of Atriplex plants and rehabilitation of soil affected by salts. Key words: Halophytes, quorum sensing, exopolysaccharide, phytoremediation

This paper focuses on the ways our societies deal with non-central corporalities, that is, those corpo ralities that depart from the socially constructed standard model of what the body should be. It begins by taking the body as a privileged locus for the communication between the biological, the individual and the sociocultural, and defining the core concepts of the ensuing analysis: corporality, bodily centrality, natural symbol, and incorporation. It then moves on to question the rise of the body in the contemporary, hiperindividualistic societies, and highlights social processes that produce the norms about what the body should be. Such norms turn into metaphors the images of bodies on the examination table, the passerelle and the podium. We then present the notion of the peripheral body as that from which emanates signs that are deval ued by the standards of body centrality. Physical deformities and obesity are shown as examples of how the body can be a source of stigma and the locus of psychological suffering in common interaction processes. We attempt to provide elements for the analytical questions that run through the paper: what processes lead a given social object to become a part of the center or, on the contrary, be relegated to the periphery? How the peripheral is socially constructed? What are the social and psychological consequences of being seen as a peripheral body? Este artigo desenvolve o seu argumento em torno da forma como lidamos socialmente com corpora lidades que se afastam da centralidade corpórea, entendida aqui como o resultado da valorização de determinados aspetos do corpo, que passam a ser tomados como modelo do que este deve ser. Come çando por situar o corpo como objeto privilegiado para a comunicação entre o biológico, o individual e o sociocultural, esclarece os conceitos que servirão à nossa análise: corporalidade, centralidade corpórea, símbolo natural e incorporação. Interroga o porquê da ascensão do corpo nas sociedades do hiperindi vidualismo contemporâneo e procura evidenciar processos sociais em curso que produzem normas sobre o que o corpo deve ser, e que metaforizamos com as imagens dos corpos na marquesa, na pas serelle e no podium. Propõe-se em seguida a noção de corpo periférico como aquele do qual emanam signos desvalorizados pelos padrões constituintes da centralidade corpórea. Exemplificamos com as deformidades físicas e com a obesidade, analisando a partir delas como pode o corpo constituir-se como fonte de estigma e locus de sofrimento psicológico nos processos interativos correntes. O percurso que aqui empreendemos é suscetível de fornecer elementos para as seguintes questões analíticas que atravessam todo o texto: que processos conduzem um determinado objeto social a tornar-se central ou, pelo contrário, a ser deslocado para a periferia? Como construímos socialmente o periférico? Que consequências pode ter nas vivências psicológicas e na vida social daqueles que são olhados como corpos periféricos?

This work was supported by Fundacao para a Ciencia e a Tecnologia, Portugal, grants PTDC/BIA-EVF/118618/2010 (J.P.S., P.A., P.G.), PTDC/AGR-ALI/118590/2010 (J.P.S., P.A., P.G., R.B.), UID/Multi/04378/2013 (J.P.S., P.G.), and SFRH/BD/77390/2011 (P.A.), by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq (CAR, process numbers 560715/2010-2 and 457499/2014-1, PBM process number 457443/2012-0) and Fundacao de Amparo a Pesquisa de Minas Gerais FAPEMIG and VALE S.A (CAR, process number RCP-00094-10). Work of C.R.L. on this project was supported by a NSERC Discovery grant. C.R.L. holds the Canada Research Chair in Evolutionary Cell and Systems Biology. The authors thank Dr. Siu Mui Tsai, Universidade de Sao Paulo, Brazil, for making available strain UFMG-CM-Y640. The natural biology of Saccharomyces cerevisiae, the best known unicellular model eukaryote, remains poorly documented and understood although recent progress has started to change this situation. Studies carried out recently in the Northern Hemisphere revealed the existence of wild populations associated with oak trees in North America, Asia, and in the Mediterranean region. However, in spite of these advances, the global distribution of natural populations of S. cerevisiae, especially in regions were oaks and other members of the Fagaceae are absent, is not well understood. Here we investigate the occurrence of S. cerevisiae in Brazil, atropical region where oaks and other Fagaceae are absent. We report a candidate natural habitat of S. cerevisiae in South America and, using whole-genome data, we uncover new lineages that appear to have as closest relatives the wild populations found in North America and Japan. A population structure analysis revealed the penetration of the wine genotype into the wild Brazilian population, a first observation of the impact of domesticated microbe lineages on the genetic structure of wild populations. Unexpectedly, the Brazilian population shows conspicuous evidence of hybridization with an American population of Saccharomyces paradoxus. Introgressions from S. paradoxus were significantly enriched in genes encoding secondary active transmembrane transporters. We hypothesize that hybridization in tropical wild lineages may have facilitated the habitat transition accompanying the colonization of the tropical ecosystem. publishersversion published

Two strains of a novel cactophilic yeast species were isolated from the columnar cactus Pilosocereus arrabidae in a sand dune ecosystem in Rio de Janeiro, Brazil. Phylogenetic analysis of sequences of the large subunit rRNA gene D1/D2 domains showed that the strains represent a sister species to Starmera caribaea, from which it differs by 21 nt substitutions and two indels. The novel species is heterothallic and the asci are deliquescent with the formation of two to four hat-shaped ascospores. The name Starmera pilosocereana sp. nov. is proposed for the species. The type strain is UFMG-CM-Y316T ( = CBS 13266T) and the allotype is UFMG-CM-Y346a ( = CBS 13265). The Mycobank number is MB 810683. In addition, Candida stellimalicola belonging to the Starmera clade, is reassigned to Starmera as a new combination.

ResumoEste artigo apresenta o Emotion Regulation Profile(ERP) como um instrumento para medir diferenças individuais na regulação de emoções. O ERP é constituído por 15 cenários que apresentam situações características de eventos da vida cotidiana desprazerosos (nove cenários) ou prazerosos (seis cenários). Cada cenário avalia a quantidade de respostas adaptativas/funcionais e desadaptativas/disfuncionais dos participantes. O instrumento foi aplicado a uma amostra de 686 pessoas entre 18 e 51 anos de idade. A amostra foi sudividida em dois grupos de 343 participantes para procedimentos de análises fatoriais exploratórias e confirmatórias. Os resultados da análise de componentes principais (primeira amostra) corroborou a estrutura bifatorial identificada no estudo original da medida, isto é, um fator de regulação das emoções negativas (down regulation) e um fator de regulação das emoções positivas (up regulation). Além disso, um conjunto de análises fatoriais confirmatórias (segunda amostra) mostrou que a estrutura bifatorial proposta teve um bom ajustamento aos dados. Por fim, foi possível propor uma versão reduzida do ERP com seis cenários (três que descrevem situações desprazerosas e três prazerosas) para avaliar adequadamente as diferentes estratégias usadas pelas pessoas na regulação de suas emoções. AbstractThis article presents the Emotion Regulation Profile (ERP) as an instrument for measuring individual differences in the regulation of emotions. The ERP consists of 15 vignettes that portray everyday life situations describing pleasant (nine vignettes) and unpleasant (six vignettes) events. Each vignette assesses the number of adaptive/functional and maladaptive/dysfunctional responses chosen by the participants. The instrument was administered to a sample of 686 people between the ages of 18 and 51. The sample was divided into two groups of 343 participants each so that exploratory and confirmatory factor analysis could be conducted. Results from the principal component analysis (first sample) corroborated the bifactorial structure identified in the original study of the measure, that is, a regulation of negative emotion factor (down regulation) and a regulation of positive emotion factor (up regulation). Furthermore, a set of confirmatory factor analysis (second sample) revealed that the proposed bifactorial structure showed good fit indices. Finally, it was possible to propose a reduced version of the ERP with six vignettes (three describing pleasant events and three describing unpleasant events) to adequately assess the different strategies people use when regulating their emotions.

O projeto de extensão “Psicologia na Comunidade” é desenvolvido pelos discentes de psicologia da Universidade Federal de Catalão e supervisionado pelo professor-orientador em reuniões que acontecem semanalmente. O projeto consiste em atender à comunidade externa de zona periférica da cidade de Catalão-GO com o objetivo de proporcionar à comunidade saúde e bem-estar, além de promover reflexões sobre aspectos da vida cotidiana. O trabalho é realizado semanalmente por três estudantes em horário fixo. Esses encontros se dão em um salão, comumente, chamado “Casa da Sopa”. Após esta prática os relatos são registrados em Diários de Campo para posterior discussão durante a supervisão com o professor, as quais são embasadas em textos correspondentes à Psicologia Social Comunitária. Assim, o presente ensaio possui como objetivo realizar um relato de experiência do trabalho desenvolvido na comunidade em um bairro da cidade supracitada, bem como realizar a integração entre a teoria e prática do psicólogo neste contexto. Até o presente momento foi possível observar o benefício deste trabalho para as pessoas que participam do grupo, no que tange ao acolhimento de seus sofrimentos psíquicos e assuntos da vida cotidiana que causam angústia e dor. Destarte, é notória a importância do psicólogo na comunidade atendendo a demanda e atuando conjuntamente com os demais profissionais da equipe de saúde do bairro. Em se tratando de uma cidade do interior de Goiás, onde a profissão do psicólogo é pouco enaltecida, faz-se necessário levar esse saber psicológico à comunidade ratificando o trabalho profícuo que a psicologia, tem a oferecer.

O presente estudo tem como objetivo mostrar os efeitos de uma intervenção dietoterápica na diabetes mellitus tipo 1 e 2, através de uma revisão bibliográfica. Como uma revisão qualitativa este trabalho utilizou como fontes bibliográficas artigos científicos foram exploradas nas bases de dados (PubMed), (SciELO), (LILACS) e (ScienceDirect) utilizando-se os Descritores em Ciências da Saúde (DeCS): “Diabetes Mellitus”, “Dietoterapia”, “Necessidades Nutricionais” ou seus equivalentes na língua inglesa. No total, 14 artigos atenderam aos critérios metodológicos e tiveram seus resultados tabulados para melhor análise e compreensão. Em sua maioria os artigos mostraram que a melhora do quadro de paciente portadores da diabetes esta associado a uma dieta saudável em que os macronutrientes estão divididos de forma equilibrada. Foi possível concluir que pacientes portadores da diabetes mellitus tem uma variedade de opções de dietas que contam com boas fontes carboidratos, lipídios e proteínas, assim podendo adequa-las aos seus gostos pessoais para uma melhor adesão a dieta.

Background: Hormonal variations are known to influence the course of multiple sclerosis (MS). Objectives: We aimed to evaluate the impact of menopause in MS course, including disease activity and disability progression. Methods: We conducted a retrospective longitudinal cohort study including all women, older than 44, post-menopausal, with a diagnosis of MS at least 1 year before menopause. We evaluated the impact of menopause in MS course comparing clinical and radiologic outcomes within 5 years before and after menopause. We repeated the analysis in subgroups of patients without disease-modifying treatment (DMT) change or co-morbidities diagnosed during the observation period, considering that those factors might also impact MS outcomes. Results: Thirty-seven women, with a mean age at the time of menopause of 49.8 (±4.06) years were included in the analysis. Within 5 years following menopause, we observed a decrease in the annualized relapse rate (0.37 ± 0.35 pre-menopause vs. 0.08 ± 0.18 post-menopause, p < 0.001) compared with the same period before menopause, while the EDSS progression rate remained stable (0.13 ± 0.24 EDSS point/year pre-menopausal vs. 0.13 ± 0.18 post-menopause, p = 0.935). EDSS progression events frequency was similar before and after the menopause (37.8 vs. 48.6%, respectively, p = 0.424). These observations persisted in patients’ subgroups without DMT switch or co-morbidities. Conclusions: Following menopause, we observed a reduction in the relapse rate, but the disability progression continued at a similar rate, compared to the pre-menopausal period. These observations persisted in the subgroup of patients without changes in DMT or co-morbidities diagnosed during the observation period.

The course of epicardial coronary arteries into a muscular tunnel under a bridge of myocardium is known as myocardial bridging (MB). This could be a benign anomaly, nevertheless, it could have a great impact on the quality of life in the setting of severe anginal symptoms. The clinical presentation and diagnosis could be challenging in those patients. The treatment options start from simple medical therapy to surgical intervention in refractory cases, the role of percutaneous coronary intervention (PCI) is limited in MB. We are describing a case of severe MB presenting as Wellens pattern with underlying left ventricular hypertrophy (LVH).

Heart rate variability, a marker of autonomic function modulation, is known to be blunted in Parkinson disease, although data remains conflicting and a putative modifying role of REM sleep behavior disorder persists unclarified. We assessed ten patients with idiopathic REM sleep behavior disorder patients, 18 patients with Parkinson disease and REM behavior disorder and eight patients with Parkinson disease without REM sleep behavior disorder. Heart rate variability analysis was performed in 5-min epochs selected from wake, Non-REM and REM polysomnography records. We compared heart rate variability measures by stage between two sets of groups: Parkinson disease vs. idiopathic RBD and patients with vs. without RBD, by using repeated measures ANOVA. There were no heart rate variability differences between Parkinson disease and idiopathic REM sleep behavior disorder groups. There were significant stage vs. group interactions (p = 0.045) regarding the high frequencies components when comparing patients with and without REM sleep behavior disorder, with the former presenting lower values and attenuation of sleep stage variations. Our study suggests that RBD is related with reduction in parasympathetic modulation of heart rate variability and blunting of sleep stage related variations.

CAPES No Brasil muitas espécies vegertais são utilizadas na alimentação e em diversos setores industriais. Neste contexto encontramos espécies da família Arecaceae. Dentro da família, o gênero Acrocomia vem se destacando por apresentar espécies com grande potencial, como por exemplo, Acrocomia intumescens Drude, que, de acordo com estudos prévios, é uma espécie promissora para o mercado alimentício e tecnológico. O objetivo deste trabalho foi caracterizar física e quimicamente o os frutos e o óleo de polpa e amêndoa de Acrocomia intumescens oriundos de nove populações localizadas em três municípios do estado de Pernambuco, nordeste do Brasil. Para condução da pesquisa, metodologias usuais de composição centesimal, carotenoides totais, perfil de ácidos graxos e características físicoquimicas do óleo foram utilizadas. As análises constataram que os frutos de Acrocomia intumescens é uma fonte rica de lipídios (≅ 40% para polpa e 50% para amêndoa, respectivamente), proteínas (≅ 8% e 19% para polpa e amêndoa, respectivamente) e carboidratos (com valores que variam entre ≅ 4 e 12% entre as populações), principalmente na sua amêndoa, com teores superiores aos alimentos convencionais. A polpa dos frutos de Acrocomia intumescens é rica em carotenoides (≅ 200µg/g) e o óleo é rico em ácidos graxos benéficos a saúde, como o ácido oleico (≅ 70%). Ainda sobre o óleo, este apresenta propriedades físico-químicas interessantes para diversos setores da indústria e dentro dos parâmetros determinados pela legislação vigente, porém por ser caracteristicamente insaturado é de fácil oxidação e necessita de estudos que melhorem sua estabilidade. Análises de similaridade mostraram que as populações estudadas podem ser agrupadas de acordo com o perfil de ácidos graxos, principalmente na amêndoa, cujo ácido láurico se mostra como marcador de população. Por fim, sendo A. intumescens uma espécie com uso alimentício tradicional e com propriedades nutricionais interessantes, uma maior divulgação da mesma se faz necessário, visto que esta pode auxiliar na complementação alimentar das comunidades do entorno onde ocorre. Além disso, o perfil de ácidos graxos e as propriedades físico-químicas dos seus óleos são excelentes para uso nas indústrias alimentícia, de sabões, cosmética e energética. In Brazil, many species of the flora are used in food and in various industrial sectors. In this context we find species of the family Arecaceae. Within the family, the genus Acrocomia has been outstanding for presenting species with great potential, such as Acrocomia intumescens Drude, which, according to previous studies, is a promising species for the food and technology market. The objective of this work was to characterize physically and chemically the fruits and oil of pulp and almond of Acrocomia intumescens from nine populations located in three municipalities of the state of Pernambuco, northeastern Brazil. To conduct the research, usual methodologies of centesimal composition, total carotenoids, fatty acid profile and physicochemical characteristics of the oil were used. The results showed that Acrocomia intumescens is a rich source of lipids (≅ 40% for pulp and 50% for almond, respectively), proteins (≅ 8% and 19% for pulp and almond, respectively) and carbohydrates which vary between ≅4 and 12% among populations), especially in their almond, with higher levels than conventional foods. The fruit pulp of Acrocomia intumescens is rich in carotenoids (≅ 200μg / g) and the oil is rich in health fatty acids, such as oleic acid (≅ 70%). Still on the oil, this presents interesting physicochemical properties for several sectors of the industry and within the parameters determined by the current legislation, but being characteristically unsaturated is of easy oxidation and needs studies that improve its stability. Similarity analyzes showed that the studied populations can be grouped according to the profile of fatty acids, mainly in the almond, whose lauric acid is shown as population marker. Finally, A. intumescens being a species with traditional food use and with interesting nutritional properties, a greater diffusion of the same is necessary, since this one can help in the alimentary complementation of the communities of the surroundings where it occurs. In addition, the fatty acid profile and physicochemical properties of its oils are excellent for use in the food, soap, cosmetics and energy industries.

Background: In recent years, gender-based domestic violence has gained significant visibility and is currently considered a priority in the field of public health. Research objective: To explore how professional and social norms and regulations impact the attitudes and practices of health and criminal justice professionals regarding domestic violence against women in Brazil and Norway. Methods: I selected a qualitative approach and gathered data through individual, semi-structured interviews with professionals from the health and criminal justice departments. I conducted 16 in-depth interviews (eight in Brazil and eight in Norway, with four health professionals and four criminal justice professionals in each country). I focused on their perceptions of existing workflows between identifying cases of violence and dealing with these cases. I analyzed the transcribed interviews using a focused open coding process. I assigned codes to statements through a line-by-line, cross-interview analysis of the raw data. Findings: The participants ranged in age from 32 to 59. All of them work with domestic violence victims both with and without supervision. According to the opinions of some participants, violence against women is a historical problem rooted in: a society that accepts the superiority of men and imposes a submissive role for women; the subordination of women; and the domination of men over decision-making and women’s lives. This problem is aggravated by women’s social, cultural, and economic dependence. Some respondents recognized and linked patriarchy to violence against women, while others seemed unaware of the concept. Both countries have regulations to provide professionals with guidance on navigating services related to domestic violence cases; and their governments try to give professionals some rules to follow when helping domestic violence victims. For many reasons, professionals do not always follow these regulations, but the situation is more complicated in Brazil, where service providers face several challenges in comparison to the circumstances in Norway. Conclusion: Personal beliefs and observed norms concerning the acceptability of domestic violence are critical risk factors for women. Individual characteristics, family, the environment, and even one’s professional profile can affect the way health or criminal justice workers perceive and deal with domestic violence cases. GLODE360

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Resumo Violência doméstica é o tipo mais comum de violência contra a mulher e resulta em sequelas nas esferas física, emocional, familiar e econômica, constituindo problema de saúde pública. Porém, a questão é tratada de maneira negligente pelos profissionais de saúde, o que contribui para sua invisibilidade. Baseado em revisão da literatura, este estudo objetivou identificar as principais dificuldades, incluindo conflitos éticos, encontradas pelos médicos na abordagem de pacientes vítimas desse tipo de violência. Os obstáculos elementares foram agrupados em três grandes eixos: questões relacionadas ao profissional de saúde; estrutura do sistema de saúde; e aspectos das vítimas de violência. Concluiu-se que o maior entrave advém do próprio profissional de saúde e envolve fatores que variam desde formação inadequada até a ocorrência de conflitos morais e éticos que culminam na culpabilização e responsabilização das vítimas pela situação de violência em que se encontram. Abstract Domestic violence is the most common type of violence against women, resulting in sequelae in the physical, emotional, family, and economic domains, constituting a public health problem. However, the issue is treated negligently by health professionals, which contributes to its invisibility. Based on a review of the literature, the objective of this study was to identify the main difficulties, including ethical conflicts, found by physicians in the approach to patients who are victims of this type of violence. The basic obstacles are grouped in 3 main axes: issues related to the health professional, to the structure of the health system and to the victims of violence. It is concluded that the greatest obstacle comes from the health professionals themselves, and involves factors ranging from inadequate training to the occurrence of moral and ethical conflicts that culminate in blaming and accountability of the victims for the situation of violence in which they were found. Resumen La violencia doméstica es el tipo de violencia más común contra la mujer y da lugar a secuelas en la esfera física, emocional, familiar y económica, constituyéndose en un problema de salud pública. Sin embargo, la cuestión es tratada de manera descuidada por parte de los profesionales de la salud, lo que contribuye a su invisibilidad. Basado en una revisión bibliográfica, este estudio tuvo como objetivo identificar las principales dificultades, incluyendo los conflictos éticos, encontradas por los médicos en el abordaje de pacientes víctimas de este tipo de violencia. Los obstáculos principales fueron agrupados en tres grandes ejes: cuestiones relacionadas con el profesional de la salud; estructura del sistema de salud; y aspectos de las víctimas de violencia. Se concluye que el mayor obstáculo adviene del propio profesional de salud e involucra factores que van desde la formación inadecuada hasta la presencia de conflictos morales y éticos que culminan en la culpabilización y la responsabilización de las víctimas por la situación de violencia en la que se encuentran.

POTENCIAL ALELOPÁTICO DE EXTRATOS DE Cyperus rotundus L. NA GERMINAÇÃO E ESTABELECIMENTO DE PLÂNTULAS DE FEIJÃO-CAUPI Este trabalho investigou os efeitos alelopáticos de extratos de Cyperus rotundus L. na germinação de sementes e crescimento inicial das plântulas de Vigna unguiculata L. Walp. Extratos alcoólicos nas concentrações 0; 1,5%; 3,0%; 4,5%; 6,0%; 7,5% e 9,0%, obtidos a partir da trituração de folhas de C. rotundus L. foram utilizados para umedecimento das folhas de papel toalha “germitest”. Os dados foram submetidos a análise de variância pelo F e as médias comparadas pelos testes de Tukey e Kruscal-Wallis, ambos a 5% de probabilidade. A primeira contagem de germinação, índice de velocidade de germinação, comprimento de raiz, comprimento da parte aérea e massa seca da raiz do feijão-caupi foram analisados de forma paramétrica, sendo constatado que apenas houve significância na variável primeira contagem e uma redução na germinação em relação ao tratamento controle em torno de 10%. Nas condições em que essa pesquisa foi realizada, os extratos alcoólicos de C. rotundus L. não afetam a germinação de sementes e crescimento inicial das plântulas de feijão-caupi.Palavras-chave: tiririca, alelopatia, interferência, plantas daninhas. ABSTRACT:This study aimed to investigate the allelopathic effects of Cyperus rotundus L. extracts on seed germination and early development of seedlings of Vigna unguiculata L. Walp. Alcoholic extracts at concentrations of 0, 1.5%, 3%, 4.5%, 6.0%, 7.5%, and 9.0% were obtained by crushing C. rotundus L. leaves used to moisten the “germitest” paper sheets. The data were subjected to analysis of variance and also both Tukey and Kruscal-Wallis tests were carried out at 5% for the data means. The first germination count, germination speed index, root length, shoot length, and dry root weight of cowpea were parametrically analyzed. The only variable with significance was first germination count. The germination reducted in relation to the control treatment around 10%. Thus, in the conditions used in this research, alcoholic extracts of C. rotundus L. did not affect either seed germination or early growth of cowpea seedlings.Keywords: nut grass, allelopathy, interference, weeds. DOI

KPC carbapenemase-producing Klebsiella pneumoniae (KPC-KP) has become a major public health challenge. Accordingly, this study sought to use a systematic review of the scientific literature to ascertain the mortality of KPC-KP infection, and analyze such mortality by country, year of publication, hospital ward, and type of interpretation used to define carbapenem resistance.A search without language restrictions was made of the MEDLINE, CENTRAL, EBSCO, LILACS and EMBASE databases from 1996 through June 2017, to locate all studies which had determined the existence of KPC-KP infection. We then performed a meta-analysis of all studies that reported KPC-KP infection-related mortality, and analyzed mortality by subgroup in accordance with standard methodology.A total of 51 papers were included in the systematic review. From 2005 through 2017, data on KPC-KP infection were reported in 5124 patients, with an average of 465 patients per year. The most widely studied type of infection was bacteremia (28∙0%). The meta-analysis showed that overall mortality for the 37 studies was 41.0% (95%CI 37.0-44.0), with the highest mortality rates being observed in oncology patients, 56.0% (95%CI 38.1-73.0), and Brazil, 51.3% (95%CI 43.0-60.0).KPC-KP infection-related mortality is high, is manifested differently in some countries, and is highest among oncology patients.

Resumen Fundamento y objetivo El radon residencial es la segunda causa de cancer de pulmon y la primera en sujetos que nunca han fumado. Galicia es un area de alta emision de radon. El objetivo de este estudio es analizar la correlacion entre mortalidad por cancer de pulmon y exposicion a radon residencial en los municipios gallegos. Material y metodo Se realizo un estudio ecologico en el que se incluyeron 192 municipios con al menos 3 mediciones de radon residencial cada uno. El numero de muertes observadas se obtuvo del Registro de Mortalidad de Galicia, calculandose posteriormente las razones de mortalidad estandarizadas (RME) de cancer de pulmon para ambos sexos durante el periodo 1980-2009. Las concentraciones medianas de radon residencial para cada municipio se correlacionaron con las RME por cancer pulmonar. Resultados La concentracion mediana de radon residencial en los municipios analizados fue de 75 Bq/m 3 , con un rango intercuartilico de 40,7 a 154 Bq/m 3 . La correlacion entre las RME por cancer de pulmon y la concentracion de radon es significativa para los varones (p = 0,023), mientras que para las mujeres la asociacion no alcanza la significacion estadistica (p = 0,087.) Conclusion Existe asociacion entre el radon residencial y la mortalidad municipal por cancer de pulmon en Galicia en varones, aunque en las mujeres esta asociacion no es estadisticamente significativa. Estos datos evidencian que el radon residencial puede aumentar el riesgo de cancer de pulmon en varones, aunque en las mujeres no se puede establecer ninguna conclusion.

O presente estudo objetivou descrever as características dos óbitos que tiveram como causa básica a hanseníase, registrados no Sistema de Informações sobre Mortalidade (SIM), e comparar estas características entre os grupos de óbitos cujos casos foram notificados e não notificados no Sistema de Informação sobre Agravos de Notificação (Sinan). Foram incluídos os óbitos com causa básica hanseníase, ocorridos no Brasil no período 2004-2009, e os casos registrados de hanseníase entre 1975-2010. Realizou-se o relacionamento probabilístico das bases do SIM e Sinan. Dos 1.463 óbitos por hanseníase registrados no SIM, 44,2% não foram encontrados no Sinan. Do total dos óbitos, a maioria foi de homens (72,5%), com 60 ou mais anos de idade (56,6%), ocorridos em hospitais (65,3%) e com assistência (45,8%). Dos 820 óbitos identificados no Sinan, 92% foram multibacilares, 45,2% tinham alta por cura no Sinan e 38,9%, óbito. Foram encontrados óbitos por hanseníase que estão registrados no SIM, mas não foram notificados no Sinan. O relacionamento das bases permitiu identificação de subregistros e inconsistências entre os sistemas. This study sought to describe the characteristics of deaths with leprosy as the underlying cause recorded in the Mortality Information System (SIM) and compare these characteristics with the groups of cases where the cause of death was reported, or failed to be reported, in the National Case Registration Database (Sinan). Deaths with leprosy as the underlying cause occurring in Brazil in the 2004-2009 period, and cases of leprosy from 1975 to 2010 were included. The probabilistic bases of SIM and Sinan were compared. Of the 1,463 deaths from leprosy recorded in SIM, 44.2% were not recorded in Sinan. Of the total number of deaths, the majority were men (72.5%), aged 60 or older (56.6%), occurring in hospitals (65.3%) and with due care (45.8%). Of the 820 deaths identified in Sinan, 92% were patients with multibacillary disease, 45.2% were discharged as cured by Sinan and 38.9% died. Deaths due to leprosy were found on SIM that were not notified to Sinan. The data base linkage enabled identification of ancillary records and inconsistencies between the systems.

Background and objective Residential radon is the second cause of lung cancer and the first in never smokers. Galicia is a high radon emission area. The objective of this study is to analyse the relationship between municipal lung cancer mortality and residential radon in Galician municipalities. Material and method We performed an ecologic study including 192 municipalities with at least 3 residential radon measurements. The observed number of lung cancer deaths was obtained from the Galician Mortality Registry. Afterwards, we calculated the standardised mortality ratios (SMRs) of lung cancer for males and females for the period comprising 1980–2009. Median municipal residential radon concentrations were correlated with lung cancer SMRs. Results Median residential radon concentration for the included municipalities was 75 Bq/m3, with an interquartile range of 40.7–154 Bq/m3. The correlation between lung cancer SMRs and municipal radon concentration was statistically significant for males (p = .023) whereas it did not reach statistical significance for females (p = .087). Conclusion There exists an association between municipal residential radon and lung cancer mortality in Galicia for males, though for women the association is not statistically significant. These results suggest that residential radon could raise the risk of lung cancer in males, though for females no association is evident.

The gas–solid separation has several industrial applications in engineering process. The collection efficiency and the energy consumption are critical variables in particles separation process. In this study, a non-linear programming problem is proposed to maximise the cyclone efficiency in a 34,560.0 ton/year particles separation–classification plant. A new process integration scheme is proposed to energy consumption minimisation. The units included in the model are a powder feeder, a high efficiency cyclone, a bag filter and a blower. Stairmand and Swift’s high efficiency cyclones models are evaluated and compared. Four particulate materials are considered: limestone, dolomite, sawdust and toner. The particles diameters range studied is 0.1–1000 (Formula presented.)m. Mass and energy balances are solved with an initial solid concentration of 500 g/m(Formula presented.). Stairmand’s cyclone proved to be more efficient than Swift for all materials analysed. The highest cyclone efficiency is achieved for sawdust ((Formula presented.) 99%). The cyclone separates more than 34,000 ton/year of particles (Formula presented.)m. The energy integration scheme consumes 43% less energy than the basic one for all cases studied. The proposed optimisation model results a valuable tool for optimal process design, reducing the environment process impact and adaptable to operate at high temperatures values with different materials. Fil: Paulo, Cecilia Inés. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; Argentina Fil: Borsa, Eugenia. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; Argentina Fil: Barbosa, Mirta Raquel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; Argentina

Carta ao Editor: A Cefaleia por Uso Excessivo de Medicação é Comum em Doentes Portugueses com Enxaqueca publishersversion published

The aim of this study was to describe and analyze history of toothache and associated factors among adolescent students enrolled in public schools of a city in Northeastern Brazil. An observational, descriptive, quantitative and cross-sectional study was conducted through the application of 4 questionnaires with 458 adolescents. By bivariate analysis, the prevalence of toothache in life was higher among younger adolescents (76.9%; p = 0.004), who have visited the dentist at least once (74.8%; p = 0.001) and who reported fear (74.9%; p = 0.006). The occurrence of dental pain in the last 6 months was low, where male (77.4%; p = 0,001) and older adolescents (73.1%; p = 0.031) reported no occurrence of pain. Through multivariate analysis, the highest prevalence of dental pain in life remained among younger adolescents (76.9%; p = 0.003) and who reported dental fear (74.9%; p = 0.006). The prevalence of toothache in the last 6 months remained low through multivariate analysis, among male and older adolescents. It could be concluded that the prevalence of toothache in life was higher than in the last 6 months, showing significant association with gender, age, visit to the dentist and dental fear.O objetivo deste estudo foi descrever e analisar o histórico de dor de dente e seus fatores associados, entre adolescentes de escolas públicas de um município do Nordeste do Brasil. Realizou-se uma pesquisa observacional, descritiva, quantitativa e transversal, através da aplicação de quatro questionários junto a 458 adolescentes. Pela análise bivariada, a prevalência de dor de dente na vida foi alta entre os adolescentes de menor idade (76,9%; p = 0,004), que visitaram o Cirurgião-Dentista alguma vez (74,8%; p = 0,001) e que relataram medo frente ao atendimento odontológico (74,9%; p = 0,006). Todavia, nos últimos 6 meses, a prevalência de dor de dente foi baixa, na qual os adolescentes do sexo masculino (77,4%; p0,001) e de maior idade (73,1%; p = 0,031) relataram justamente não terem sentido dor. Quando da análise multivariada, a maior prevalência de dor de dente na vida se manteve entre os adolescentes de menor idade (76,9%; p = 0,003) e que relataram medo (74,9%; p = 0,006). A prevalência de dor de dente nos últimos 6 meses se manteve baixa na análise multivariada, entre os adolescentes do sexo masculino e de maior idade. Conclui-se que a prevalência de dor de dente na vida foi maior do que nos últimos 6 meses, havendo associação significativa com os fatores: sexo, idade, visita ao Cirurgião-Dentista e sensação de medo.

• Although previous reports suggested that blood pressure may play a role in the emergence of symptoms in patients with capsular warning syndrome, this was not confirmed in our cohort of patients.

RESUMO: Introdução: A busca ativa de óbitos é uma estratégia de captação de eventos que não foram informados ao Sistema de Informações sobre Mortalidade (SIM) do Ministério da Saúde (MS). Sua importância na redução do sub-registro de óbitos e na avaliação da operacionalização do sistema de informações é amplamente conhecida. Objetivo: Descrever a metodologia e os principais achados da pesquisa de busca ativa de óbitos realizada em 2013, estabelecendo a contribuição das diferentes fontes de informação. Métodos: A pesquisa foi realizada em 79 municípios brasileiros. Foram investigadas diversas fontes oficiais e não oficiais de informações sobre óbitos de residentes nesses municípios. Todas as fontes de informações investigadas e os casos encontrados foram digitados em um painel on-line. A segunda etapa da pesquisa foi de confirmação dos casos para verificar as informações sobre o ano do óbito e o município de residência, assim como para completar informações faltantes. Resultados: Foram encontrados 2.265 óbitos que não foram informados ao SIM. Desses, 49,3% foram encontrados em fontes não oficiais, cemitérios e funerárias. Em alguns municípios rurais, condições precárias de sepultamento foram encontradas em cemitérios no meio da mata, sem registro do falecido. Os fatores de correção foram inversamente associados ao nível de adequação das informações de mortalidade. Conclusão: Os achados confirmam a associação entre o nível de adequação das informações e a cobertura do registro de óbitos, e indicam que a aplicação de pesquisas de busca ativa é um método efetivo para capturar óbitos não informados ao MS. ABSTRACT: Introduction: The proactive search of deaths is a strategy for capturing events that were not informed to the Mortality Information System of Ministry of Health. Its importance to reduce underreporting of deaths and to evaluate the operation of the information system is widely known. Objective: To describe the methodology and main findings of the Proactive Search of Deaths, 2013, establishing the contribution of different information sources. Methods: The research was carried out in 79 Brazilian municipalities. We investigated several official and unofficial sources of information about deaths of municipality residents. Every information source investigated and all cases found in each source were typed in an on-line panel. The second stage of the research was the confirmation of cases to verify information of year and residence and to complete missing information. For all confirmed cases, we estimated the completeness of death registration and correction factors according to the adequacy level of mortality information. Results: We found 2,265 deaths that were not informed to the Mortality Information System. From those, 49.3% were found in unofficial sources, cemeteries and funeral homes. In some rural municipalities, precarious burial conditions were found in cemeteries in the middle of the forest and no registration of the deceased. Correction factors were inversely associated to the adequacy level of mortality information. Conclusion: The findings confirm the association between level of information adequacy and completeness of death registration, and indicate that the application of the proactive search is an effective method to capture deaths not informed to the Ministry of Health.

Background Early identification of patients with cerebral amyloid angiopathy (CAA) is relevant considering the increased risk for cerebral hemorrhage. A new set of diagnostic criteria for CAA was recently proposed, which include the presence of superficial siderosis. We aimed to assess the impact of applying these criteria regarding use of antithrombotic therapy. Methods Review of consecutive patients admitted to a Neurology Department from 2014 to 2016, with acute parenchymal or subarachnoid hemorrhage and/or atypical transient focal neurological episodes. Patients with a possible or probable CAA according to the original and modified Boston criteria were included. Information was collected regarding presentation, imaging findings and concomitant therapy. Results Among a total of 1436 admitted patients, 52 with acute hemorrhagic lesions or atypical TFNE were screened: 22 met criteria for CAA; 4 were deemed too young; 21 had other causes for hemorrhagic parenchymal lesions; and 5 had uncertain diagnosis. Using the modified Boston criteria, 8 patients fulfilled criteria for probable CAA and 14 for possible CAA. When we applied the original Boston criteria to the same patients, only 7 fulfilled criteria for probable CAA and 8 for possible CAA. Among the additional patients identified with the modified Boston criteria, 4 were using antithrombotic therapy. Conclusions The use of the modified Boston criteria allowed for the identification of 7 additional patients, more than half of which were taking antithrombotic therapy. Systematic use of these criteria could have an important impact in clinical practice. Raising awareness on the different presentations of CAA among clinicians is of the utmost importance.

Objectives/background Because both REM sleep behavior disorder (RBD) and Obstructive Sleep Apnea (OSA) can present with similar symptoms, it is important to understand the influence of OSA in the clinical manifestations of RBD and whether RBD modulates OSA severity. Our objectives were to compare: 1. the intensity of non-motor symptoms between RBD patients with (RBD-OSA) and without OSA (RBD-non-OSA), and 2. polysomnographic features between RBD-OSA and OSA without RBD (OSA-non-RBD) patients. Methods 32 RBD cases were divided in two groups according to the presence of moderate to severe OSA [Apnea Hypopnea Index (AIH) > 14] (RBD-OSA vs. RBD-non-OSA). Non-motor symptoms were assessed with Montreal Cognitive Assessment Scale, SCOPA-Sleep and the Non-Motor Symptom Scale (NMSS) for Parkinson's disease. RBD-OSA patients were compared to 20 OSA-non-RBD patients matched for age, AHI and gender. Results Compared to RBD-non-OSA (n = 22) patients, RBD-OSA patients (n = 10) showed significantly higher scores in SCOPA-Sleep Daytime and NMSS Attention/Memory, Gastrointestinal and Urinary domains, as well as higher sleep fragmentation, more oxygen desaturation and higher AIH in NREM sleep. RBD-OSA patients presented with less O 2 desaturation, snoring, and BMI when compared to OSA-non-RBD patients. Discussion Our data suggests that OSA contributes to hypersomnolence, gastro-intestinal, memory, and urinary complaints in RBD patients. RBD patients seem to have a milder OSA phenotype (possible reflecting a protective role conferred by the maintenance of muscle tone during REM sleep) and to be less prone to obesity and snoring than non-RBD patients.

Background: Tetrabenazine (TBZ) is commonly used in hyperkinetic movement disorders. In this retrospective study, we aimed to assess the TBZ effectiveness and adverse events (AEs) in Huntington disease (HD), vascular chorea, tics, dystonia, tardive oromandibular (OM) dyskinesia and other tardive syndromes (TS). Methods: Qualitative analysis of clinical response was used to estimate TBZ effectiveness. TBZ-associated AE frequency and subsequent discontinuation rate were used to estimate tolerability; the tolerability profile was measured through the TBZ minimal dose and exposure time required to elicit AEs. Results: Of 108 included patients, 87% had a clinically meaningful improvement sustained over a period of 40 months. TBZ-responder rate ranged from 100% in HD to 62.5% and 77.1% in tic disorders and OM dyskinesia, respectively ( p < 0.001). TBZ-associated AE frequency ranged from 40.9% in other TS and 41.7% in vascular chorea and HD, to 60% in OM dyskinesia ( p < 0.001). The most common AEs were Parkinsonism (51.8%) and psychiatric disorders (25%). The ‘other AEs’ category (mainly somnolence) presented the shortest minimal exposure time (3 months). AE-eliciting dose differed from 18.8 mg and 25 mg in tics and tardive disorders, to 75 mg in HD ( p = 0.003). Patients with AEs were tendentiously older at TBZ initiation ( p = 0.022). Conclusions: TBZ proved an effective and relatively well tolerated treatment in hyperkinetic disorders, with excellent results in HD. AEs were more common in OM dyskinesia, which may be related to higher age at TBZ initiation. TBZ-associated somnolence and Parkinsonism were more frequent during the titration and maintenance periods, respectively.