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20,723 results on '"R. Taylor"'

201. Mortality after multivitamin supplementation: Nearly 35‐year follow‐up of the randomized Linxian Dysplasia Nutrition Intervention Trial

Author

Jin‐Hu Fan, Jian‐Bing Wang, Huan Yang, Sanford M. Dawsey, Philip R. Taylor, You‐Lin Qiao, and Christian C. Abnet

Subjects
Male, Cancer Research, Hyperplasia, Esophageal Neoplasms, Oncology, Dietary Supplements, Carcinoma, Squamous Cell, Humans, Female, Vitamins, Aged, Follow-Up Studies
Abstract

The objective of this study was to update the association between multivitamin supplementation and total or cause-specific mortality in a population with a high prevalence of undernutrition in China.The Linxian Dysplasia Nutrition Intervention Trial was a randomized, double-blind, placebo-controlled trial in which 3318 persons aged 40-69 years with esophageal squamous dysplasia were assigned to receive daily multivitamin supplementation or a placebo for 6 years and were followed for 29 years. The primary outcome was esophageal/gastric cardia cancer mortality. The data were analyzed with Cox proportional hazards regression models. Subgroup analyses were performed by common characteristics such as age and gender.The cumulative total mortality was 83.5%. Multivitamin supplementation did not affect total or cause-specific mortality in the participants as a whole (hazard ratio [HR], 0.96; 95% confidence interval [CI], 0.89-1.03). Subgroup analyses showed that no association between multivitamin supplementation and all-cause mortality was observed in men (HR, 0.90; 95% CI, 0.81-1.01), women (HR, 1.01; 95% CI, 0.91-1.12), younger participants (HR, 0.97; 95% CI, 0.87-1.08), or older participants (HR, 0.94; 95% CI, 0.85-1.04). Significant reductions in heart disease mortality (HR, 0.64; 95% CI, 0.47-0.87) and cerebrovascular disease mortality (HR, 0.74; 95% CI, 0.56-1.00) were seen in older men. In a subgroup of younger men and a subgroup of moderate or severe dysplasia, subjects receiving multivitamin supplementation had a lower risk of esophageal/cardia cancer mortality (HR for younger men, 0.76; 95% CI, 0.58-0.99; HR for moderate or severe dysplasia, 0.76; 95% CI, 0.58-1.00). No association between multivitamin supplementation and any cause-specific mortality was observed in a mild dysplasia population.Multivitamin supplementation in a population with esophageal squamous dysplasia was not associated with the risk of total mortality in the 35-year follow-up of this randomized controlled trial. In light of this and previous trials, multivitamin supplements should be used thoughtfully to improve health status of populations with esophageal squamous dysplasia.Multivitamin supplementation is common, yet its effect on mortality is unclear. The aim of this study was to update the long-term effects of multivitamin supplementation on total and cause-specific mortality during nearly 35 years of follow-up in the Linxian Dysplasia Nutrition Intervention Trial in China. Multivitamin supplementation in a population with esophageal squamous dysplasia was not associated with the risk of total mortality in the 35-year follow-up of this randomized controlled trial, and this indicates that multivitamin supplements should be used thoughtfully to improve health status.

Published
2022

202. Therapeutic potential of vitamin B1 derivative benfotiamine from diabetes to COVID-19

Author

Kieran V Allowitz, John J Yoo, Justin R Taylor, Omar A Baloch, Kyra Harames, and Kota V Ramana

Subjects
Pharmacology, Drug Discovery, Molecular Medicine
Abstract

Benfotiamine (S-benzoylthiamine-O-monophosphate), a unique, lipid-soluble derivative of thiamine, is the most potent allithiamine found in roasted garlic, as well as in other herbs of the genus Allium. In addition to potent antioxidative properties, benfotiamine has also been shown to be a strong anti-inflammatory agent with therapeutic significance to several pathological complications. Specifically, over the past decade or so, benfotiamine has been shown to prevent not only various secondary diabetic complications but also several inflammatory complications such as uveitis and endotoxemia. Recent studies also demonstrate that this compound could be used to prevent the symptoms associated with various infectious diseases such as HIV and COVID-19. In this review article, the authors discuss the significance of benfotiamine in the prevention of various pathological complications.

Published
2022

203. Data from Genomic Patterns of Malignant Peripheral Nerve Sheath Tumor (MPNST) Evolution Correlate with Clinical Outcome and Are Detectable in Cell-Free DNA

Author

Cortes-Ciriano, Isidro, primary, Steele, Christopher D., primary, Piculell, Katherine, primary, Al-Ibraheemi, Alyaa, primary, Eulo, Vanessa, primary, Bui, Marilyn M., primary, Chatzipli, Aikaterini, primary, Dickson, Brendan C., primary, Borcherding, Dana C., primary, Feber, Andrew, primary, Galor, Alon, primary, Hart, Jesse, primary, Jones, Kevin B., primary, Jordan, Justin T., primary, Kim, Raymond H., primary, Lindsay, Daniel, primary, Miller, Colin, primary, Nishida, Yoshihiro, primary, Proszek, Paula Z., primary, Serrano, Jonathan, primary, Sundby, R. Taylor, primary, Szymanski, Jeffrey J., primary, Ullrich, Nicole J., primary, Viskochil, David, primary, Wang, Xia, primary, Snuderl, Matija, primary, Park, Peter J., primary, Flanagan, Adrienne M., primary, Hirbe, Angela C., primary, Pillay, Nischalan, primary, and Miller, David T., primary

Published
2023
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204. Supplementary Figures 1-15 from Genomic Patterns of Malignant Peripheral Nerve Sheath Tumor (MPNST) Evolution Correlate with Clinical Outcome and Are Detectable in Cell-Free DNA

Author

Cortes-Ciriano, Isidro, primary, Steele, Christopher D., primary, Piculell, Katherine, primary, Al-Ibraheemi, Alyaa, primary, Eulo, Vanessa, primary, Bui, Marilyn M., primary, Chatzipli, Aikaterini, primary, Dickson, Brendan C., primary, Borcherding, Dana C., primary, Feber, Andrew, primary, Galor, Alon, primary, Hart, Jesse, primary, Jones, Kevin B., primary, Jordan, Justin T., primary, Kim, Raymond H., primary, Lindsay, Daniel, primary, Miller, Colin, primary, Nishida, Yoshihiro, primary, Proszek, Paula Z., primary, Serrano, Jonathan, primary, Sundby, R. Taylor, primary, Szymanski, Jeffrey J., primary, Ullrich, Nicole J., primary, Viskochil, David, primary, Wang, Xia, primary, Snuderl, Matija, primary, Park, Peter J., primary, Flanagan, Adrienne M., primary, Hirbe, Angela C., primary, Pillay, Nischalan, primary, and Miller, David T., primary

Published
2023
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205. Abstract 2219: Urine cell-free DNA multi-omics to detect molecular residual disease and predict survival in bladder cancer patients

Author

Chauhan, Pradeep Singh, primary, Shiang, Alexander L., additional, Alahi, Irfan, additional, Sundby, R. Taylor, additional, Feng, Wenjia, additional, Gungoren, Bilge, additional, Nawaf, Cayce, additional, Chen, Kevin, additional, Babbra, Ramandeep K., additional, Harris, Peter K., additional, Qaium, Faridi, additional, Hatscher, Casey, additional, Antiporda, Anna, additional, Brunt, Lindsey, additional, Mayer, Lindsey R., additional, Shern, Jack F., additional, Baumann, Brian C., additional, Kim, Eric H., additional, Reimers, Melissa A., additional, Smith, Zachary L., additional, and Chaudhuri, Aadel A., additional

Published
2023
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206. Supplementary Tables S1 and S2 from Genomic Patterns of Malignant Peripheral Nerve Sheath Tumor (MPNST) Evolution Correlate with Clinical Outcome and Are Detectable in Cell-Free DNA

Author

Cortes-Ciriano, Isidro, primary, Steele, Christopher D., primary, Piculell, Katherine, primary, Al-Ibraheemi, Alyaa, primary, Eulo, Vanessa, primary, Bui, Marilyn M., primary, Chatzipli, Aikaterini, primary, Dickson, Brendan C., primary, Borcherding, Dana C., primary, Feber, Andrew, primary, Galor, Alon, primary, Hart, Jesse, primary, Jones, Kevin B., primary, Jordan, Justin T., primary, Kim, Raymond H., primary, Lindsay, Daniel, primary, Miller, Colin, primary, Nishida, Yoshihiro, primary, Proszek, Paula Z., primary, Serrano, Jonathan, primary, Sundby, R. Taylor, primary, Szymanski, Jeffrey J., primary, Ullrich, Nicole J., primary, Viskochil, David, primary, Wang, Xia, primary, Snuderl, Matija, primary, Park, Peter J., primary, Flanagan, Adrienne M., primary, Hirbe, Angela C., primary, Pillay, Nischalan, primary, and Miller, David T., primary

Published
2023
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207. Table S3 from Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma

Author

Feingold, Paul L., primary, Surman, Deborah R., primary, Brown, Kate, primary, Xu, Yuan, primary, McDuffie, Lucas A., primary, Shukla, Vivek, primary, Reardon, Emily S., primary, Crooks, Daniel R., primary, Trepel, Jane B., primary, Lee, Sunmin, primary, Lee, Min-Jung, primary, Gao, Shaojian, primary, Xi, Sichuan, primary, McLoughlin, Kaitlin C., primary, Diggs, Laurence P., primary, Beer, David G., primary, Nancarrow, Derek J., primary, Neckers, Leonard M., primary, Davis, Jeremy L., primary, Hoang, Chuong D., primary, Hernandez, Jonathan M., primary, Schrump, David S., primary, and Ripley, R. Taylor, primary

Published
2023
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208. Tables S1 and S2 from Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma

Author

Feingold, Paul L., primary, Surman, Deborah R., primary, Brown, Kate, primary, Xu, Yuan, primary, McDuffie, Lucas A., primary, Shukla, Vivek, primary, Reardon, Emily S., primary, Crooks, Daniel R., primary, Trepel, Jane B., primary, Lee, Sunmin, primary, Lee, Min-Jung, primary, Gao, Shaojian, primary, Xi, Sichuan, primary, McLoughlin, Kaitlin C., primary, Diggs, Laurence P., primary, Beer, David G., primary, Nancarrow, Derek J., primary, Neckers, Leonard M., primary, Davis, Jeremy L., primary, Hoang, Chuong D., primary, Hernandez, Jonathan M., primary, Schrump, David S., primary, and Ripley, R. Taylor, primary

Published
2023
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209. Supplemental Figures 1-15 from Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma

Author

Feingold, Paul L., primary, Surman, Deborah R., primary, Brown, Kate, primary, Xu, Yuan, primary, McDuffie, Lucas A., primary, Shukla, Vivek, primary, Reardon, Emily S., primary, Crooks, Daniel R., primary, Trepel, Jane B., primary, Lee, Sunmin, primary, Lee, Min-Jung, primary, Gao, Shaojian, primary, Xi, Sichuan, primary, McLoughlin, Kaitlin C., primary, Diggs, Laurence P., primary, Beer, David G., primary, Nancarrow, Derek J., primary, Neckers, Leonard M., primary, Davis, Jeremy L., primary, Hoang, Chuong D., primary, Hernandez, Jonathan M., primary, Schrump, David S., primary, and Ripley, R. Taylor, primary

Published
2023
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210. Data from Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma

Author

Feingold, Paul L., primary, Surman, Deborah R., primary, Brown, Kate, primary, Xu, Yuan, primary, McDuffie, Lucas A., primary, Shukla, Vivek, primary, Reardon, Emily S., primary, Crooks, Daniel R., primary, Trepel, Jane B., primary, Lee, Sunmin, primary, Lee, Min-Jung, primary, Gao, Shaojian, primary, Xi, Sichuan, primary, McLoughlin, Kaitlin C., primary, Diggs, Laurence P., primary, Beer, David G., primary, Nancarrow, Derek J., primary, Neckers, Leonard M., primary, Davis, Jeremy L., primary, Hoang, Chuong D., primary, Hernandez, Jonathan M., primary, Schrump, David S., primary, and Ripley, R. Taylor, primary

Published
2023
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211. Supplementary Table S3 from A Phase II Window of Opportunity Study of Neoadjuvant PD-L1 versus PD-L1 plus CTLA-4 Blockade for Patients with Malignant Pleural Mesothelioma

Author

Lee, Hyun-Sung, primary, Jang, Hee-Jin, primary, Ramineni, Maheshwari, primary, Wang, Daniel Y., primary, Ramos, Daniela, primary, Choi, Jong Min, primary, Splawn, Taylor, primary, Espinoza, Monica, primary, Almarez, Michelle, primary, Hosey, Leandria, primary, Jo, Eunji, primary, Hilsenbeck, Susan, primary, Amos, Christopher I., primary, Ripley, R. Taylor, primary, and Burt, Bryan M., primary

Published
2023
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212. Supplementary Appendix S1 from A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma

Author

Ligon, John A., primary, Sundby, R. Taylor, primary, Wedekind, Mary F., primary, Arnaldez, Fernanda I., primary, Del Rivero, Jaydira, primary, Wiener, Lori, primary, Srinivasan, Ramaprasad, primary, Spencer, Melissa, primary, Carbonell, Amanda, primary, Lei, Haiyan, primary, Shern, John, primary, Steinberg, Seth M., primary, Figg, William D., primary, Peer, Cody J., primary, Zimmerman, Sara, primary, Moraly, Josquin, primary, Xu, Xia, primary, Fox, Stephen, primary, Chan, King, primary, Barbato, Michael I., primary, Andresson, Thorkell, primary, Taylor, Naomi, primary, Pacak, Karel, primary, Killian, J. Keith, primary, Dombi, Eva, primary, Linehan, W. Marston, primary, Miettinen, Markku, primary, Piekarz, Richard, primary, Helman, Lee J., primary, Meltzer, Paul, primary, Widemann, Brigitte, primary, and Glod, John, primary

Published
2023
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213. Supplementary Figure S5 from A Phase II Window of Opportunity Study of Neoadjuvant PD-L1 versus PD-L1 plus CTLA-4 Blockade for Patients with Malignant Pleural Mesothelioma

Author

Lee, Hyun-Sung, primary, Jang, Hee-Jin, primary, Ramineni, Maheshwari, primary, Wang, Daniel Y., primary, Ramos, Daniela, primary, Choi, Jong Min, primary, Splawn, Taylor, primary, Espinoza, Monica, primary, Almarez, Michelle, primary, Hosey, Leandria, primary, Jo, Eunji, primary, Hilsenbeck, Susan, primary, Amos, Christopher I., primary, Ripley, R. Taylor, primary, and Burt, Bryan M., primary

Published
2023
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214. Supplementary Methods S1 from A Phase II Window of Opportunity Study of Neoadjuvant PD-L1 versus PD-L1 plus CTLA-4 Blockade for Patients with Malignant Pleural Mesothelioma

Author

Lee, Hyun-Sung, primary, Jang, Hee-Jin, primary, Ramineni, Maheshwari, primary, Wang, Daniel Y., primary, Ramos, Daniela, primary, Choi, Jong Min, primary, Splawn, Taylor, primary, Espinoza, Monica, primary, Almarez, Michelle, primary, Hosey, Leandria, primary, Jo, Eunji, primary, Hilsenbeck, Susan, primary, Amos, Christopher I., primary, Ripley, R. Taylor, primary, and Burt, Bryan M., primary

Published
2023
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216. Supplementary Table S2 from A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma

Author

Ligon, John A., primary, Sundby, R. Taylor, primary, Wedekind, Mary F., primary, Arnaldez, Fernanda I., primary, Del Rivero, Jaydira, primary, Wiener, Lori, primary, Srinivasan, Ramaprasad, primary, Spencer, Melissa, primary, Carbonell, Amanda, primary, Lei, Haiyan, primary, Shern, John, primary, Steinberg, Seth M., primary, Figg, William D., primary, Peer, Cody J., primary, Zimmerman, Sara, primary, Moraly, Josquin, primary, Xu, Xia, primary, Fox, Stephen, primary, Chan, King, primary, Barbato, Michael I., primary, Andresson, Thorkell, primary, Taylor, Naomi, primary, Pacak, Karel, primary, Killian, J. Keith, primary, Dombi, Eva, primary, Linehan, W. Marston, primary, Miettinen, Markku, primary, Piekarz, Richard, primary, Helman, Lee J., primary, Meltzer, Paul, primary, Widemann, Brigitte, primary, and Glod, John, primary

Published
2023
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217. Supplementary Figure 2 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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218. Supplementary Table 6 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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219. Supplementary Figure S5 from Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells

Author

Rao, Mahadev, primary, Atay, Scott M., primary, Shukla, Vivek, primary, Hong, Young, primary, Upham, Trevor, primary, Ripley, R. Taylor, primary, Hong, Julie A., primary, Zhang, Mary, primary, Reardon, Emily, primary, Fetsch, Patricia, primary, Miettinen, Markku, primary, Li, Xinmin, primary, Peer, Cody J., primary, Sissung, Tristan, primary, Figg, William D., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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220. Supplementary Data from Therapeutic Targeting of Macrophage Plasticity Remodels the Tumor-Immune Microenvironment

Author

Jang, Hee-Jin, primary, Lee, Hyun-Sung, primary, Yu, Wendong, primary, Ramineni, Maheshwari, primary, Truong, Cynthia Y., primary, Ramos, Daniela, primary, Splawn, Taylor, primary, Choi, Jong Min, primary, Jung, Sung Yun, primary, Lee, Ju-Seog, primary, Wang, Daniel Y., primary, Sederstrom, Joel M., primary, Pietropaolo, Massimo, primary, Kheradmand, Farrah, primary, Amos, Christopher I., primary, Wheeler, Thomas M., primary, Ripley, R. Taylor, primary, and Burt, Bryan M., primary

Published
2023
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221. Supplementary Table S1 from Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells

Author

Rao, Mahadev, primary, Atay, Scott M., primary, Shukla, Vivek, primary, Hong, Young, primary, Upham, Trevor, primary, Ripley, R. Taylor, primary, Hong, Julie A., primary, Zhang, Mary, primary, Reardon, Emily, primary, Fetsch, Patricia, primary, Miettinen, Markku, primary, Li, Xinmin, primary, Peer, Cody J., primary, Sissung, Tristan, primary, Figg, William D., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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222. Supplementary Table 1 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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223. Supplementary Figure 4 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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224. Supplementary Materials and Methods from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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225. Supplementary Figure 6 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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226. Supplementary Figure 3 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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227. Supplementary Table 5 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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228. Supplementary Figure 1 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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229. Supplementary Table 2 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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230. Supplementary Table 3 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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231. Supplementary Figure 5 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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232. Supplementary Table 4 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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233. Supplementary Methods from Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells

Author

Rao, Mahadev, primary, Atay, Scott M., primary, Shukla, Vivek, primary, Hong, Young, primary, Upham, Trevor, primary, Ripley, R. Taylor, primary, Hong, Julie A., primary, Zhang, Mary, primary, Reardon, Emily, primary, Fetsch, Patricia, primary, Miettinen, Markku, primary, Li, Xinmin, primary, Peer, Cody J., primary, Sissung, Tristan, primary, Figg, William D., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
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234. Supplementary Table 2 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of ABCG2 and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells

Author

Zhang, Mary, primary, Mathur, Aarti, primary, Zhang, Yuwei, primary, Xi, Sichuan, primary, Atay, Scott, primary, Hong, Julie A., primary, Datrice, Nicole, primary, Upham, Trevor, primary, Kemp, Clinton D., primary, Ripley, R. Taylor, primary, Wiegand, Gordon, primary, Avital, Itzak, primary, Fetsch, Patricia, primary, Mani, Haresh, primary, Zlott, Daniel, primary, Robey, Robert, primary, Bates, Susan E., primary, Li, Xinmin, primary, Rao, Mahadev, primary, and Schrump, David S., primary

Published
2023
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235. Supplementary Table 3 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of ABCG2 and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells

Author

Zhang, Mary, primary, Mathur, Aarti, primary, Zhang, Yuwei, primary, Xi, Sichuan, primary, Atay, Scott, primary, Hong, Julie A., primary, Datrice, Nicole, primary, Upham, Trevor, primary, Kemp, Clinton D., primary, Ripley, R. Taylor, primary, Wiegand, Gordon, primary, Avital, Itzak, primary, Fetsch, Patricia, primary, Mani, Haresh, primary, Zlott, Daniel, primary, Robey, Robert, primary, Bates, Susan E., primary, Li, Xinmin, primary, Rao, Mahadev, primary, and Schrump, David S., primary

Published
2023
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236. Supplementary Figure 4 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of ABCG2 and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells

Author

Zhang, Mary, primary, Mathur, Aarti, primary, Zhang, Yuwei, primary, Xi, Sichuan, primary, Atay, Scott, primary, Hong, Julie A., primary, Datrice, Nicole, primary, Upham, Trevor, primary, Kemp, Clinton D., primary, Ripley, R. Taylor, primary, Wiegand, Gordon, primary, Avital, Itzak, primary, Fetsch, Patricia, primary, Mani, Haresh, primary, Zlott, Daniel, primary, Robey, Robert, primary, Bates, Susan E., primary, Li, Xinmin, primary, Rao, Mahadev, primary, and Schrump, David S., primary

Published
2023
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237. Data from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of ABCG2 and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells

Author

Zhang, Mary, primary, Mathur, Aarti, primary, Zhang, Yuwei, primary, Xi, Sichuan, primary, Atay, Scott, primary, Hong, Julie A., primary, Datrice, Nicole, primary, Upham, Trevor, primary, Kemp, Clinton D., primary, Ripley, R. Taylor, primary, Wiegand, Gordon, primary, Avital, Itzak, primary, Fetsch, Patricia, primary, Mani, Haresh, primary, Zlott, Daniel, primary, Robey, Robert, primary, Bates, Susan E., primary, Li, Xinmin, primary, Rao, Mahadev, primary, and Schrump, David S., primary

Published
2023
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238. Supplementary Figure 3 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of ABCG2 and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells

Author

Zhang, Mary, primary, Mathur, Aarti, primary, Zhang, Yuwei, primary, Xi, Sichuan, primary, Atay, Scott, primary, Hong, Julie A., primary, Datrice, Nicole, primary, Upham, Trevor, primary, Kemp, Clinton D., primary, Ripley, R. Taylor, primary, Wiegand, Gordon, primary, Avital, Itzak, primary, Fetsch, Patricia, primary, Mani, Haresh, primary, Zlott, Daniel, primary, Robey, Robert, primary, Bates, Susan E., primary, Li, Xinmin, primary, Rao, Mahadev, primary, and Schrump, David S., primary

Published
2023
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239. Supplementary Table 1 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of ABCG2 and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells

Author

Zhang, Mary, primary, Mathur, Aarti, primary, Zhang, Yuwei, primary, Xi, Sichuan, primary, Atay, Scott, primary, Hong, Julie A., primary, Datrice, Nicole, primary, Upham, Trevor, primary, Kemp, Clinton D., primary, Ripley, R. Taylor, primary, Wiegand, Gordon, primary, Avital, Itzak, primary, Fetsch, Patricia, primary, Mani, Haresh, primary, Zlott, Daniel, primary, Robey, Robert, primary, Bates, Susan E., primary, Li, Xinmin, primary, Rao, Mahadev, primary, and Schrump, David S., primary

Published
2023
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240. Supplementary Figure 2 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of ABCG2 and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells

Author

Zhang, Mary, primary, Mathur, Aarti, primary, Zhang, Yuwei, primary, Xi, Sichuan, primary, Atay, Scott, primary, Hong, Julie A., primary, Datrice, Nicole, primary, Upham, Trevor, primary, Kemp, Clinton D., primary, Ripley, R. Taylor, primary, Wiegand, Gordon, primary, Avital, Itzak, primary, Fetsch, Patricia, primary, Mani, Haresh, primary, Zlott, Daniel, primary, Robey, Robert, primary, Bates, Susan E., primary, Li, Xinmin, primary, Rao, Mahadev, primary, and Schrump, David S., primary

Published
2023
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241. Supplementary Methods from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of ABCG2 and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells

Author

Zhang, Mary, primary, Mathur, Aarti, primary, Zhang, Yuwei, primary, Xi, Sichuan, primary, Atay, Scott, primary, Hong, Julie A., primary, Datrice, Nicole, primary, Upham, Trevor, primary, Kemp, Clinton D., primary, Ripley, R. Taylor, primary, Wiegand, Gordon, primary, Avital, Itzak, primary, Fetsch, Patricia, primary, Mani, Haresh, primary, Zlott, Daniel, primary, Robey, Robert, primary, Bates, Susan E., primary, Li, Xinmin, primary, Rao, Mahadev, primary, and Schrump, David S., primary

Published
2023
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242. Supplementary Figure 1 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of ABCG2 and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells

Author

Zhang, Mary, primary, Mathur, Aarti, primary, Zhang, Yuwei, primary, Xi, Sichuan, primary, Atay, Scott, primary, Hong, Julie A., primary, Datrice, Nicole, primary, Upham, Trevor, primary, Kemp, Clinton D., primary, Ripley, R. Taylor, primary, Wiegand, Gordon, primary, Avital, Itzak, primary, Fetsch, Patricia, primary, Mani, Haresh, primary, Zlott, Daniel, primary, Robey, Robert, primary, Bates, Susan E., primary, Li, Xinmin, primary, Rao, Mahadev, primary, and Schrump, David S., primary

Published
2023
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244. Adeno-associated virus type 2 in US children with acute severe hepatitis.

Author

Servellita, Venice, Servellita, Venice, Sotomayor Gonzalez, Alicia, Lamson, Daryl M, Foresythe, Abiodun, Huh, Hee Jae, Bazinet, Adam L, Bergman, Nicholas H, Bull, Robert L, Garcia, Karla Y, Goodrich, Jennifer S, Lovett, Sean P, Parker, Kisha, Radune, Diana, Hatada, April, Pan, Chao-Yang, Rizzo, Kyle, Bertumen, J Bradford, Morales, Christina, Oluniyi, Paul E, Nguyen, Jenny, Tan, Jessica, Stryke, Doug, Jaber, Rayah, Leslie, Matthew T, Lyons, Zin, Hedman, Hayden D, Parashar, Umesh, Sullivan, Maureen, Wroblewski, Kelly, Oberste, M Steven, Tate, Jacqueline E, Baker, Julia M, Sugerman, David, Potts, Caelin, Lu, Xiaoyan, Chhabra, Preeti, Pediatric Hepatitis of Unknown Etiology Working Group, Ingram, L Amanda, Shiau, Henry, Britt, William, Gutierrez Sanchez, Luz Helena, Ciric, Caroline, Rostad, Christina A, Vinjé, Jan, Kirking, Hannah L, Wadford, Debra A, Raborn, R Taylor, St George, Kirsten, Chiu, Charles Y, Servellita, Venice, Servellita, Venice, Sotomayor Gonzalez, Alicia, Lamson, Daryl M, Foresythe, Abiodun, Huh, Hee Jae, Bazinet, Adam L, Bergman, Nicholas H, Bull, Robert L, Garcia, Karla Y, Goodrich, Jennifer S, Lovett, Sean P, Parker, Kisha, Radune, Diana, Hatada, April, Pan, Chao-Yang, Rizzo, Kyle, Bertumen, J Bradford, Morales, Christina, Oluniyi, Paul E, Nguyen, Jenny, Tan, Jessica, Stryke, Doug, Jaber, Rayah, Leslie, Matthew T, Lyons, Zin, Hedman, Hayden D, Parashar, Umesh, Sullivan, Maureen, Wroblewski, Kelly, Oberste, M Steven, Tate, Jacqueline E, Baker, Julia M, Sugerman, David, Potts, Caelin, Lu, Xiaoyan, Chhabra, Preeti, Pediatric Hepatitis of Unknown Etiology Working Group, Ingram, L Amanda, Shiau, Henry, Britt, William, Gutierrez Sanchez, Luz Helena, Ciric, Caroline, Rostad, Christina A, Vinjé, Jan, Kirking, Hannah L, Wadford, Debra A, Raborn, R Taylor, St George, Kirsten, and Chiu, Charles Y

Abstract

As of August 2022, clusters of acute severe hepatitis of unknown aetiology in children have been reported from 35 countries, including the USA1,2. Previous studies have found human adenoviruses (HAdVs) in the blood from patients in Europe and the USA3-7, although it is unclear whether this virus is causative. Here we used PCR testing, viral enrichment-based sequencing and agnostic metagenomic sequencing to analyse samples from 16 HAdV-positive cases from 1 October 2021 to 22 May 2022, in parallel with 113 controls. In blood from 14 cases, adeno-associated virus type 2 (AAV2) sequences were detected in 93% (13 of 14), compared to 4 (3.5%) of 113 controls (P < 0.001) and to 0 of 30 patients with hepatitis of defined aetiology (P < 0.001). In controls, HAdV type 41 was detected in blood from 9 (39.1%) of the 23 patients with acute gastroenteritis (without hepatitis), including 8 of 9 patients with positive stool HAdV testing, but co-infection with AAV2 was observed in only 3 (13.0%) of these 23 patients versus 93% of cases (P < 0.001). Co-infections by Epstein-Barr virus, human herpesvirus 6 and/or enterovirus A71 were also detected in 12 (85.7%) of 14 cases, with higher herpesvirus detection in cases versus controls (P < 0.001). Our findings suggest that the severity of the disease is related to co-infections involving AAV2 and one or more helper viruses.

Published
2023

245. Improving satellite monitoring of coastal inundations of pelagic Sargassum algae with wind and citizen science data

Author

Putman, Nathan F. (author), Beyea, R. Taylor (author), Iporac, Lowell Andrew R. (author), Triñanes, Joaquin (author), Ackerman, Emilie G. (author), Olascoaga, Maria J. (author), Appendini, Christian M. (author), Arriaga, Jaime (author), Collado-Vides, Ligia (author), Putman, Nathan F. (author), Beyea, R. Taylor (author), Iporac, Lowell Andrew R. (author), Triñanes, Joaquin (author), Ackerman, Emilie G. (author), Olascoaga, Maria J. (author), Appendini, Christian M. (author), Arriaga, Jaime (author), and Collado-Vides, Ligia (author)

Abstract

Massive blooms of pelagic Sargassum algae have caused serious problems to coastal communities and ecosystems throughout the tropical Atlantic, Caribbean Sea, and Gulf of Mexico since 2011. Efforts to monitor and predict these occurrences are challenging owing to the vast area impacted and the complexities associated with the proliferation and movement of Sargassum. Sargassum Inundation Reports (SIRs) were first produced in 2019 to estimate the potential risk to coastlines throughout the Intra-American Sea at weekly intervals at 10 km resolution. SIRs use satellite-based data products to estimate beaching risk from the amount of offshore Sargassum (quantified by a Floating Algal density index). Here we examine whether including wind metrics improves the correspondence between the offshore Floating Algal density index and observations of Sargassum along the coastline. For coastal observations, we quantified the percent coverage of Sargassum in photos obtained from the citizen science project “Sargassum Watch” that collects time-stamped, georeferenced photos at beaches throughout the region. Region-wide analyses indicate that including shoreward wind velocity with SIR risk indices greatly improves the correspondence with coastal observations of Sargassum beaching compared to SIR risk indices alone. Site-specific analyses of photos from southeast Florida, USA, and data from a continuous video monitoring study at Puerto Morelos, Mexico, suggest potential uncertainties in the suite of factors controlling Sargassum beaching. Nonetheless, the inclusion of wind velocity in the SIR algorithm appears to be a promising avenue for improving regional risk indices., Environmental Fluid Mechanics

Published
2023
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248. Human-centric AI: philosophical and community-centric considerations

Author

Randon R. Taylor, Bessie O’Dell, and John W. Murphy

Subjects
Human-Computer Interaction, Philosophy, Artificial Intelligence
Abstract

This article provides a course of correction in the discourse surrounding human-centric AI by elucidating the philosophical underpinning that serves to create a view that AI is divorced from human-centric values. Next, we espouse the need to explicitly designate stakeholder- or community-centric values which are needed to resolve the issue of alignment. To achieve this, we present two frameworks, Ubuntu and maximum feasible participation. Finally, we demonstrate how employing the aforementioned frameworks in AI can benefit society by flattening the current top-down social hierarchies as AI is currently being utilized. Implications are discussed.

Published
2023

249. Experimental and computational evaluation of knee implant wear and creep under in vivo and ISO boundary conditions

Author

Michael J. Dreyer, Seyyed Hamed Hosseini Nasab, Philippe Favre, Fabian Amstad, Rowena Crockett, William R. Taylor, and Bernhard Weisse

Abstract

Experimental knee implant wear testing according to ISO 14243 is a standard procedure, but it inherently possesses limitations for preclinical evaluations due to extended testing periods and costly infrastructure. In an effort to overcome these limitations, we hereby develop and experimentally validate a finite element (FE) based algorithm, including a novel cross-shear and contact pressure dependent wear and creep model, and apply it towards understanding the sensitivity of wear outcomes to the applied boundary conditions.Specifically, we investigated the application of in vivo data for level walking from the publicly available “Stan” dataset, which contains single representative tibiofemoral loads and kinematics derived from in vivo measurements of six subjects, and compared wear outcomes against those obtained using the ISO standard boundary conditions. To provide validation of the numerical models, this comparison was reproduced experimentally on a six-station knee wear simulator over 5 million cycles, testing the same implant Stan’s data was obtained from.Experimental implementation of Stan’s boundary conditions in displacement control resulted in approximately three times higher wear rates (4.4 vs. 1.6 mm3per million cycles) and a more anterior wear pattern compared to the ISO standard in force control. While a force-controlled ISO FE model was unable to reproduce the bench test kinematics, and thus wear rate, displacement-controlled FE models accurately predicted the laboratory wear tests for both ISO and Stan boundary conditions. The credibility of the in silico wear and creep model was further established per the ASME V&V-40 standard. The model is thus suitable for supporting future patient specific models and development of novel implant designs.

Published
2023

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