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A cobalt-catalyzed imidazolyl-directed asymmetric phospha-Michael-type reaction for synthesizing chiral organophosphorus compounds is presented. This protocol features broad substrate scope, good functional group tolerance, and mild conditions.

To explore the protective effect and mechanism of Kuntai (KT) Capsule on angiotensin II (Ang II)-induced hypertension in ovariectomized (OVX) rats.Fifty-four rats were randomly divided into 6 groups according to a random number table, 9 in each group: control, OVX sham+Ang II, OVX, OVX+Ang II, OVX+Ang II +ECompared with the OVX+Ang II group, the systolic blood pressure of OVX+Ang II +KT group was significantly lowered (P0.05) but not the diastolic blood pressure. Besides, SOD2 and TRX protein levels in mycardial tissues were significantly reduced in the OVX+Ang II +KT group compared with the OVX+Ang II group (P0.05). Oxidative stress serum markers MDA and SOD were down- and up-regulated in the OVX+Ang II +KT group, respectively (P0.05). Compared with OVX+Ang II group, the levels of cardiac proteins beclin-1 and LC3II/LC3 I in OVX+Ang II +KT group were also up-regulated (P0.05), and the expression levels of p-PI3K, p-AKT and mTOR protein were down-regulated (P0.05).KT could protect blood pressure of Ang II-induced OVX rats by inhibiting oxidative stress and up-regulating protective autophagy.

3d-Metals have been identified as economic and sustainable alternatives to palladium, the frequently used metal in transition-metal-catalyzed cross-couplings. However, cobalt has long stood behind its neighboring elements, nickel and copper, in asymmetric radical couplings, owing to its high catalytic activity in the absence of ligands. Here, we disclose an asymmetric metallaphotoredox catalysis (AMPC) strategy for the dynamic kinetic resolution (DKR) of racemic heterobiaryls, which represents the first example of visible-light-induced, asymmetric radical couplings for the construction of axial chirality. This success can also be extended to the reductive cross-coupling variant featuring on more easily available feedstocks. The keys to these successes are the rational design of a sustainable AMPC system by merging asymmetric cobalt catalysis with organic photoredox catalysis and, perhaps more importantly, the identification of an efficient chiral polydentate ligand.

Medium-sized nitrogen heterocycles including 8-membered lactams are important in the synthetic and pharmaceutical chemistry fields because of their presence in a variety of natural products and dru...

Hypoganus fedorenkoi sp. nov. (Figs. 1–3, 7, 9, 11, 14–17, 18) Type material. Holotype, male (ZMMU): “N Vietnam, Lao Cai Prov., Hoang Lien Son Mt. ridge, env. Fansipan Mt, Tram Ton, h=1950–2100, 17.VII.2007, leg. D. Fedorenko ” [Northern Vietnam, Lào Cai Prov., Hoang Lien Son Mt. Range, env. Fansipan Mt., Tram Ton Pass]. Diagnosis. This species resembles its congeners known from China, namely H. tibetis Čechovský & Kubáň, 1997, H. sichuanensis Schimmel & Tarnawski, 2017 and H. wennae Qiu & Prosvirov, 2017, but can be easily distinguished from them by the several characters (mostly compared the characters of males, except for H. sichuanensis, which known only from females). It differs from H. tibetis and H. sichuanensis in the almost completely blackish body (blackish-brown or partially brownish in the latter two), medially emarginated frons (almost straight or rounded in the latter two), rather long and narrowly sharply pointed hind angles of the pronotum (shorter and less sharply pointed in the latter two), and more parallel-sided elytra not broadened in the posterior 1/3 (widest in the posterior 1/ 3 in the latter two). Hypoganus fedorenkoi sp. nov. seems most closely related to H. wennae but differs in the notably longer and strongly serrated antenna, which slightly exceed the hind angle of pronotum (just reach the hind angle of pronotum and with sub-triangular middle antennomeres in H. wennae) (Figs. 7, 8), large and strongly protuberant eye (medium-sized and moderately convex in H. wennae), pronotum more parallel-sided (notably narrower at the fore angles than near hind angles in H. wennae) (Figs. 11, 12), paramere almost straight in the anterior 1/3 (distinctly curved in the anterior 1/ 3 in H. wennae), and penis rather slender, subgradually narrowed at the apex (the penis robust, sharply narrowed at the apex in the anterior 1/3) (Figs. 18, 19). Description. Male (holotype): body length 12.3 mm; body width 3.6 mm; pronotum length 2.6 mm; pronotum width 2.7 mm; elytra length 8.5 mm; elytra width 3.6 mm; antenna length 4.6 mm; antennomere IV length 0.5 mm, width 0.4 mm. Body shining, smooth, elongate and rather flat, dorsum sparsely covered with small punctures and fine golden pubescence (at head and elytral interstriae punctures denser and notably larger), underside with relatively denser punctation and pubescence; body blackish with deep brown admixture, eye and antennomeres IV–XI dark brown; mouthparts, apex of prosternal lobe, partially hind angles of pronotum, base of hypomeron, apex of prosternal process, apex of abdomen, and partially legs reddish-brown; claws yellowish (Figs. 1–3). Head: vertex trapeziform between eyes, with shallow V-shaped depression, surface rather unevenly densely covered with large, deep and umbilicate punctures (intervals between punctures varying from 0.5 to 3 diameters of one puncture), with sparse, short pubescence (Fig. 11). Frons medially slightly emarginated; frontal carina step-like protruding, ridged above antennae, medially smoothed (Fig. 9). Eye large, strongly convex (Figs. 9, 11). Antenna slightly exceeding hind angle of pronotum, with yellowish recumbent short pubescence, pubescence very dense at antennomeres IV to XI, antennomeres II to XI apically with certain erect long setae, strongly serrated from antennomere IV to X, and gradually narrower from antennomere IV on; scape elongate, ovate; pedicel shortest, almost conical, slightly longer than wide; flagellum conical, distinctly longer than wide; antennomeres IV to X triangular; antennomere XI trapeziform at apex (Fig. 7). Labrum transverse, narrow, wrinkled and punctate, medially with some long yellowish setae (Fig. 9). Thorax: pronotum slightly wider than long, widest near middle, only slightly narrowed towards fore angles, markedly narrowed toward hind angles; smooth, sparsely covered with small, shallow, simple punctures (intervals between punctures mostly longer that 3 diameters of one puncture) and short pubescence; disc slightly convex, with shallow longitudinal groove in posterior 1/2; hind angles long, distinctly divergent, strongly narrowed at apex and sharply pointed (Fig. 11). Hypomeron punctate and pubescent similarly to pronotum, in posterior 1/4 impunctate; prosternal sutures very slightly emarginated in anterior 1/4; prosternum with uneven surface, slightly depressed laterally in middle 1/3, punctate and pubescent as hypomeron over most of anterior 1/2, denser than hypomeron in posterior 1/2 (at disc intervals between punctures about as long as 2–3 diameters of one puncture); prosternal lobe with dense, large, deep and umbilicate punctures, anterior margin distinctly edged, posteriorly with transverse median depression; prosternal process rather thin and long, sloping behind procoxae, slightly tapered at apex, bluntly rounded (Fig. 3). Metaventrite punctate and pubescent mostly as posterior 1/2 of prosternum. Scutellum (Fig. 11) flat, tongue-shaped, very sparsely punctate and pubescent; anterior margin slightly convex, apex obtusely truncated. Elytra elongate, almost parallel-sided over basal 3/4 of length, gradually narrowing in posterior 1/4, widest behind middle; interstriae clearly elevated, smooth, sparsely punctate and pubescent; each stria with a row of punctures, each puncture elongate, intervals between punctures about equal to 1–3 lengths of one puncture (Fig. 1). Metathoracic wings completely developed, reaching apices of elytra. Legs slender, tarsomeres from I to IV getting shorter, tarsomere V longest, tarsomere IV shortest. Abdomen: punctate and pubescent similarly to metaventrite, but punctures on average denser, in posterior 1/2 of apical ventrite punctures large, deep and umbilicate; each ventrite with rather deep depression sublaterally (Fig. 3), ventrites III to V with unusual proportions, probably due to malformation. Tergite VIII cordiform, densely covered with microtrichia, except for most of basal portion, laterally and at apical margin with some short and long setae (Fig. 14); tergite IX densely covered with microtrichia in lateral portions, at lateral margins with some short and long setae, apical portion triangularly concave (Fig. 16); tergite X densely covered with microtrichia, except for bare basal portion, obtusely rounded at apex (Fig. 16); sternite VIII transverse, lateral portions densely covered with microtrichia, pubescent with some short and long setae, membranous part densely covered with microtrichia in anterior 1/2, with several short setae at anterolateral portions (Fig. 15); sternite IX obtusely rounded at apex, rather densely pubescent with short setae in posterior 1/3, at apical margin with short and several long setae, medial part with some short setae (Fig. 17). Genitalia: penis slender, slightly longer than paramere, gradually narrowed towards apex, at apical part constricted; paramere almost straight in anterior 1/2, at apex shortly rounded, apical margin almost straight, apical hook sharply pointed (Fig. 18). Female and immature stages. Unknown. Distribution. Northern Vietnam (Lào Cai Province). Bionomics. According to the label data and considering the known biology of other congeners, it is likely that H. fedorenkoi sp. nov. inhabits tropical evergreen forests at the middle altitudes of the Hoang Lien Son Mountain Range (Figs. 21, 22), but the exact ecological preferences of this species are unknown. Possibly H. fedorenkoi sp. nov. is nocturnal, as indicated by its strongly enlarged eyes. Etymology. Named in the honour of its collector, the distinguished entomologist Dmitry N. Fedorenko., Published as part of Prosvirov, Alexander S. & Qiu, Lu, 2023, Hypoganus fedorenkoi sp. nov., the first record of the genus in Vietnam (Coleoptera: Elateridae: Dendrometrinae), pp. 54-60 in Zootaxa 5306 (1) on pages 55-59, DOI: 10.11646/zootaxa.5306.1.2, http://zenodo.org/record/8054225, {"references":["Schimmel, R. & Tarnawski, D. (2017) New species of the genera Calambus Thomson, and Hypoganus Kiesenwetter (Coleoptera: Elateridae) from China. Journal of Asia-Pacific Entomology, 20, 293 - 297. https: // doi. org / 10.1016 / j. aspen. 2016.11.007","Qiu, L. & Prosvirov, A. S. (2017) A new species of Hypoganus Kiesenwetter, 1858 (Coleoptera: Elateridae: Dendrometrinae) from China, with notes on the Palaearctic species of the genus. Zootaxa, 4324 (2), 348 - 362. https: // doi. org / 10.11646 / zootaxa. 4324.2.7"]}

Prosvirov, Alexander S., Qiu, Lu (2023): Hypoganus fedorenkoi sp. nov., the first record of the genus in Vietnam (Coleoptera: Elateridae: Dendrometrinae). Zootaxa 5306 (1): 54-60, DOI: 10.11646/zootaxa.5306.1.2, URL: http://dx.doi.org/10.11646/zootaxa.5306.1.2

Aim: To achieve accurate detection of circulating tumor cells (CTCs) in a large-volume sample. Materials & methods: Silica nanoparticles were crosslinked layer-by-layer on glass slides as the substrate of a chip using polyacrylic acid. Polyacrylic acid was immobilized as a spacer and capture ligands were immobilized on the spacer. Results: The chip can be integrally applied to capture, post-treatment and imaging detection for CTCs. The detected cell numbers were 33 and 40 for 9 cell/ml samples and clinical blood samples (7.5 ml), respectively. The detection ratio of positive samples was 100%. Conclusion: The significantly increased detected number for CTCs indicates that this methodology may avoid or greatly reduce the false-negative ratio of positive clinical samples.

To investigate the prevalence of preterm birth (PTB) and the risk factors for different gestational age subgroups of preterm birth in China.We carried out a descriptive cross-sectional study encompassing all singleton live births (24The prevalence of PTB was 7.4% (15,833/215,254) in singleton births. After adjusting for maternal age, parity, and potential risk factors in univariate analysis, the high-risk factors for PTB at32 weeks were placental abruption (aOR=41.52; 95% CI, 25.89-66.58), placenta previa (aOR=40.04; 95% CI, 32.00-50.09), chorioamnionitis (aOR=11.06; 95% CI, 8.738-14.02), and hypertension disorders in pregnancy (HDP) (aOR=3.564; 95% CI, 2.930-4.335). Intrahepatic cholestasis of pregnancy (ICP) was significantly associated with PTB at 34-36 weeks (aOR=5.763; 95% CI, 5.049-6.577), particularly with spontaneous PTB (aOR=10.04; 95% CI, 8.79-11.47). Gestational diabetes mellitus (GDM) was significantly associated with PTB at 34-36 weeks only (aOR=1.156; 95% CI, 1.054-1.267).Placental abruption, placenta previa, chorioamnionitis, and HDP were more predictive of early PTB; GDM and ICP were more predictive of late PTB.

The transition-metal-catalyzed cyanations of aryl halides are among the most used methods for synthesizing aryl nitriles. Despite tremendous advances, cyanating an aryl halide in a facile and benig...