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715 results on '"Qaddoumi, Ibrahim"'

209. LG-10GENETIC ALTERATIONS IN UNCOMMON LOW-GRADE NEUROEPITHELIAL TUMORS: BRAF, FGFR1, AND MYB MUTATIONS OCCUR AT HIGH FREQUENCY AND ALIGN WITH MORPHOLOGY

Author

Qaddoumi, Ibrahim, primary, Orisme, Wilda, additional, Wen, Ji, additional, Santiago, Teresa, additional, Dalton, James, additional, Tang, Bo, additional, Haupfear, Kelly, additional, Punchihewa, Chandanamali, additional, Easton, John, additional, Shurtleff, Sheila, additional, Gajjar, Amar, additional, Boop, Frederick, additional, Klimo, Paul, additional, Baker, Suzanne, additional, Zhang, Jinghui, additional, Wu, Gang, additional, Downing, James, additional, Tatevossian, Ruth, additional, and Ellison, David, additional

Published
2016
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211. EPT-15A PHASE1/2 CLINICAL TRIAL OF VELIPARIB (ABT-888) AND RADIATION FOLLOWED BY MAINTENANCE THERAPY WITH VELIPARIB AND TEMOZOLOMIDE (TMZ) IN PATIENTS WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG): A PEDIATRIC BRAIN TUMOR CONSORTIUM INTERIM REPORT OF PHASE II STUDY

Author

Baxter, Patricia, primary, Su, Jack, additional, Li, Xiao-nan, additional, Thomas, Arzu Onar, additional, Billups, Catherine, additional, Thompson, Patrick, additional, Poussaint, Tina, additional, McKeegan, Evelyn, additional, Wan, Xia, additional, Ansell, Peter, additional, Giranda, Vincent, additional, Paulino, Arnold, additional, Kilburn, Lindsay, additional, Qaddoumi, Ibrahim, additional, Broniscer, Alberto, additional, Blaney, Susan, additional, Boyett, James, additional, and Fouladi, Maryam, additional

Published
2016
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213. DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas

Author

Jeyapalan, Jennie N., primary, Doctor, Gabriel T., additional, Jones, Tania A., additional, Alberman, Samuel N., additional, Tep, Alexander, additional, Haria, Chirag M., additional, Schwalbe, Edward C., additional, Morley, Isabel C. F., additional, Hill, Alfred A., additional, LeCain, Magdalena, additional, Ottaviani, Diego, additional, Clifford, Steven C., additional, Qaddoumi, Ibrahim, additional, Tatevossian, Ruth G., additional, Ellison, David W., additional, and Sheer, Denise, additional

Published
2016
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214. Profound hearing loss following surgery in pediatric patients with posterior fossa low-grade glioma.

Author

Ghazwani, Yahya, Qaddoumi, Ibrahim, Bass, Johnnie K., Shengjie Wu, Chiang, Jason, Boop, Frederick, Gajjar, Amar, and Sadighi, Zsila

Subjects
*HEARING disorders, *INFRATENTORIAL brain tumors, *BRAIN surgery, *TUMORS in children, *CHILD patients
Abstract

Background: Hearing loss may occur in patients with posterior fossa low-grade glioma who undergo surgery. Methods: We retrospectively reviewed 217 patients with posterior fossa low-grade glioma, including 115 for whom results of hearing tests performed after surgery and before chemotherapy or radiation therapy were available. We explored the association of UHL with age at diagnosis, sex, race, tumor location, extent of resection, posterior fossa syndrome, ventriculoperitoneal shunt placement, and histology. Results: Of the 115 patients, 15 (13.0%: 11 male, 6 black, 8 white, 1 multiracial; median age 7 years [range, 1.3- 17.2 years]) had profound UHL after surgery alone or before receiving ototoxic therapy. Median age at tumor diagnosis was 6.8 years (range, 0.7-14.1 years), and median age at surgery was 6.8 years (range, 0.7-14.1 years). Patients with UHL had pathology characteristic of pilocytic astrocytoma (n = 10), ganglioglioma (n = 4), or lowgrade astrocytoma (n = 1). Of these 15 patients, 4 underwent biopsy, 1 underwent gross total resection, 1 underwent near-total resection, and 9 underwent subtotal resection. UHL was more frequent in black patients than in white patients (OR 7.3, P = .007) and less frequent in patients who underwent gross total resection or near-total resection than in those who underwent subtotal resection (OR 0.11, P = .02). Conclusions: Children undergoing surgery for posterior fossa low-grade glioma are at risk for UHL, which may be related to race or extent of resection. These patients should receive postoperative audiologic testing, as earlier intervention may improve outcomes. [ABSTRACT FROM AUTHOR]

Published
2018
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215. Management and outcome of focal low-grade brainstem tumors in pediatric patients: the St. Jude experience

Author

Klimo, Paul, Pai Panandiker, Atmaram S., Thompson, Clinton J., Boop, Frederick A., Qaddoumi, Ibrahim, Gajjar, Amar, Armstrong, Gregory T., Ellison, David W., Kun, Larry E., Ogg, Robert J., and Sanford, Robert A.

Subjects
Male, Adolescent, Biopsy, Infant, Glioma, Kaplan-Meier Estimate, Prognosis, Survival Analysis, Article, Disease-Free Survival, Neurosurgical Procedures, Treatment Outcome, Child, Preschool, Brain Stem Neoplasms, Humans, Female, Child, Case Management, Follow-Up Studies, Retrospective Studies
Abstract

Whereas diffuse intrinsic pontine gliomas generally have a short symptom duration and more cranial nerve involvement, focal brainstem gliomas are commonly low grade, with fewer cranial neuropathies. Although these phenotypic distinctions are not absolute predictors of outcome, they do demonstrate correlation in most cases. Because there is a limited literature on focal brainstem gliomas in pediatric patients, the objective of this paper was to report the management and outcome of these tumors.The authors reviewed the records of all children diagnosed with radiographically confirmed low-grade focal brainstem gliomas from 1986 to 2010. Each patient underwent biopsy or resection for tissue diagnosis. Event-free survival (EFS) and overall survival were evaluated. Univariate analysis was conducted to identify demographic and treatment variables that may affect EFS.Fifty-two patients (20 girls, 32 boys) with follow-up data were identified. Median follow-up was 10.0 years, and the median age at diagnosis was 6.5 years (range 1-17 years). The tumor locations were midbrain (n = 22, 42%), pons (n = 15, 29%), and medulla (n = 15, 29%). Surgical extirpation was the primary treatment in 25 patients (48%). The 5- and 10-year EFS and overall survival were 59%/98% and 52%/90%, respectively. An event or treatment failure occurred in 24 patients (46%), including 5 deaths. Median time to treatment failure was 3.4 years. Disease progression in the other 19 patients transpired within 25.1 months of diagnosis. Thirteen of these patients received radiation, including 11 within 2 months of primary treatment failure. Although children with intrinsic tumors had slightly better EFS at 5 years compared with those with exophytic tumors (p = 0.054), this difference was not significant at 10 years (p = 0.147). No other variables were predictive of EFS.Surgery suffices in many children with low-grade focal brainstem gliomas. Radiation treatment is often reserved for disease progression but offers comparable disease control following biopsy. In the authors' experience, combining an assessment of clinical course, imaging, and tumor biopsy yields a reasonable model for managing children with focal brainstem tumors.

Published
2013

220. Video-Teleconferencing in Pediatric Neuro-Oncology: Ten Years of Experience.

Author

Amayiri, Nisreen, Swaidan, Maisa, Abuirmeileh, Najiyah, Al-Hussaini, Maysa, Tihan, Tarik, Drake, James, Musharbash, Awni, Qaddoumi, Ibrahim, Tabori, Uri, Halalsheh, Hadeel, Bartels, Ute, and Bouffet, Eric

Subjects
CENTRAL nervous system tumors, REOPERATION, NERVOUS system tumors, CENTRAL nervous system, MIDDLE-income countries
Abstract

Purpose: The management of central nervous system tumors is challenging in low- and middle-income countries. Little is known about applicability of twinning initiatives with high-income countries in neuro-oncology. In 2004, a monthly neuro-oncology video-teleconference program was started between King Hussein Cancer Center (Amman, Jordan) and the Hospital for Sick Children (Toronto, Ontario, Canada). More than 100 conferences were held and > 400 cases were discussed. The aim of this work was to assess the sustainability of such an initiative and the evolution of the impact over time. Methods: We divided the duration in to three eras according to the initial 2 to 3 years of work of three consecutive oncologists in charge of the neuro-oncology program at King Hussein Cancer Center. We retrospectively reviewed the written minutes and compared the preconference suggested plans with the postconference recommendations. Impact of changes on the patient care was recorded. Results: Thirty-three sets of written minutes (covering 161 cases) in the middle era and 32 sets of written minutes (covering 122 cases) in the last era were compared with the initial experience (20 meetings, 72 cases). Running costs of these conferences has dropped from $360/h to < $40/h. Important concepts were introduced, such as multidisciplinary teamwork, second-look surgery, and early referral. Suggestions for plan changes have decreased from 44% to 30% and 24% in the respective consecutive eras. Most recommendations involved alternative intervention modalities or pathology review. Most of these recommendations were followed. Conclusion: Video-teleconferencing in neuro-oncology is feasible and sustainable. With time, team experience is built while the percentage and the type of treatment modifications change. Commitment and motivation helped maintain this initiative rather than availability of financial resources. Improvement in patients' care was achieved, in particular, with the implementation of a multidisciplinary team and the continuous effort to implement recommendations. [ABSTRACT FROM AUTHOR]

Published
2017
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223. Abstract 35: Novel genetic and clinical determinants of Constitutional Mismatch Repair Deficiency syndrome: Report from the CMMRD consortium

Author

Bakry, Doua, primary, Campbell, Brittany, additional, Durno, Carol, additional, Aronson, Melyssa, additional, Alharbi, Qasim, additional, Alharbi, Musa, additional, Constantini, Shlomi, additional, Pollett, Aaron, additional, Ben-Shachar, Shay, additional, Lerner-Ellis, Jordan, additional, Gallinger, Steven, additional, Elhasid, Ronit, additional, Farah, Roula, additional, Qaddoumi, Ibrahim, additional, Mistry, Matthew, additional, Lily, Ramyar, additional, Keiles, Steve, additional, Dvir, Rina, additional, Stephens, Derek, additional, Malkin, David, additional, Bouffet, Eric, additional, Hawkins, Cynthia, additional, and Tabori, Uri, additional

Published
2014
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224. Cognitive function and social attainment in adult survivors of retinoblastoma: A report from the St. Jude Lifetime Cohort Study

Author

Brinkman, Tara M., primary, Merchant, Thomas E., additional, Li, Zhenghong, additional, Brennan, Rachel, additional, Wilson, Matthew, additional, Hoehn, Mary Ellen, additional, Qaddoumi, Ibrahim, additional, Phipps, Sean, additional, Srivastava, Deokumar, additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, and Krull, Kevin R., additional

Published
2014
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225. SIOP PODC adapted treatment recommendations for standard-risk medulloblastoma in low and middle income settings

Author

Parkes, Jeannette, primary, Hendricks, Marc, additional, Ssenyonga, Peter, additional, Mugamba, John, additional, Molyneux, Elizabeth, additional, Schouten-van Meeteren, Antoinette, additional, Qaddoumi, Ibrahim, additional, Fieggen, Graham, additional, Luna-Fineman, Sandra, additional, Howard, Scott, additional, Mitra, Dipayan, additional, Bouffet, Eric, additional, Davidson, Alan, additional, and Bailey, Simon, additional

Published
2014
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226. Delayed methotrexate excretion in infants and young children with primary central nervous system tumors and postoperative fluid collections

Author

Wright, Karen D., primary, Panetta, John C., additional, Onar-Thomas, Arzu, additional, Reddick, Wilburn E., additional, Patay, Zoltan, additional, Qaddoumi, Ibrahim, additional, Broniscer, Alberto, additional, Robinson, Giles, additional, Boop, Frederick A., additional, Klimo, Paul, additional, Ward, Deborah, additional, Gajjar, Amar, additional, and Stewart, Clinton F., additional

Published
2014
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228. Pathologic Risk-based Adjuvant Chemotherapy for Unilateral Retinoblastoma Following Enucleation

Author

Sullivan, Erin M., primary, Wilson, Matthew W., additional, Billups, Catherine A., additional, Wu, Jianrong, additional, Merchant, Thomas E., additional, Brennan, Rachel C., additional, Haik, Barrett G., additional, Shulkin, Barry, additional, Free, Tammy M., additional, Given, Vickie, additional, Rodriguez-Galindo, Carlos, additional, and Qaddoumi, Ibrahim, additional

Published
2014
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229. A phase 1 study of AZD6244 in children with recurrent or refractory low-grade gliomas: A Pediatric Brain Tumor Consortium report.

Author

Banerjee, Anuradha, primary, Jakacki, Regina, additional, Onar-Thomas, Arzu, additional, Wu, Shengjie, additional, Nicolaides, Theodore, additional, Turner, David, additional, Richardson, Stacye, additional, Young-Poussaint, Tina, additional, Phillips, Joanna J, additional, Prados, Michael, additional, Packer, Roger, additional, Qaddoumi, Ibrahim A, additional, Gururangan, Sridharan, additional, Goldman, Stewart, additional, Pollack, Ian, additional, Doyle, L. Austin, additional, Stewart, Clinton F., additional, Boyett, James M., additional, and Fouladi, Maryam, additional

Published
2014
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230. Phase II Trial of Erlotinib during and after Radiotherapy in Children with Newly Diagnosed High-Grade Gliomas

Author

Qaddoumi, Ibrahim, primary, Kocak, Mehmet, additional, Pai Panandiker, Atmaram S., additional, Armstrong, Gregory T., additional, Wetmore, Cynthia, additional, Crawford, John R., additional, Lin, Tong, additional, Boyett, James M., additional, Kun, Larry E., additional, Boop, Fredrick A., additional, Merchant, Thomas E., additional, Ellison, David W., additional, Gajjar, Amar, additional, and Broniscer, Alberto, additional

Published
2014
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232. Genetic and clinical determinants of constitutional mismatch repair deficiency syndrome: Report from the constitutional mismatch repair deficiency consortium

Author

Bakry, Doua, primary, Aronson, Melyssa, additional, Durno, Carol, additional, Rimawi, Hala, additional, Farah, Roula, additional, Alharbi, Qasim Kholaif, additional, Alharbi, Musa, additional, Shamvil, Ashraf, additional, Ben-Shachar, Shay, additional, Mistry, Matthew, additional, Constantini, Shlomi, additional, Dvir, Rina, additional, Qaddoumi, Ibrahim, additional, Gallinger, Steven, additional, Lerner-Ellis, Jordan, additional, Pollett, Aaron, additional, Stephens, Derek, additional, Kelies, Steve, additional, Chao, Elizabeth, additional, Malkin, David, additional, Bouffet, Eric, additional, Hawkins, Cynthia, additional, and Tabori, Uri, additional

Published
2014
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234. Evaluation of amifostine for protection against cisplatin-induced serious hearing loss in children treated for average-risk or high-risk medulloblastoma

Author

Gurney, James G., primary, Bass, Johnnie K., additional, Onar-Thomas, Arzu, additional, Huang, Jie, additional, Chintagumpala, Murali, additional, Bouffet, Eric, additional, Hassall, Tim, additional, Gururangan, Sridharan, additional, Heath, John A., additional, Kellie, Stewart, additional, Cohn, Richard, additional, Fisher, Michael J., additional, Panandiker, Atmaram Pai, additional, Merchant, Thomas E., additional, Srinivasan, Ashok, additional, Wetmore, Cynthia, additional, Qaddoumi, Ibrahim, additional, Stewart, Clinton F., additional, Armstrong, Gregory T., additional, Broniscer, Alberto, additional, and Gajjar, Amar, additional

Published
2014
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235. Childhood central nervous system tumors at MAHAK’s Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran

Author

Mehrvar, Azim, primary, Faranoush, Mohammad, additional, Hedayati Asl, Amir Abbas, additional, Tashvighi, Maryam, additional, Fazeli, Mohammad Ali, additional, Qaddoumi, Ibrahim, additional, Mehrvar, Narjes, additional, Sobuti, Behdad, additional, Jafarpour, Ali, additional, Ravan parsa, Reza, additional, Zangooei, Rokhsaneh, additional, Alebouyeh, Mardawig, additional, and Vossough, Parvaneh, additional

Published
2013
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237. A prospective phase II study to determine the efficacy of GDC 0449 (vismodegib) in adults with recurrent medulloblastoma (MB): A Pediatric Brain Tumor Consortium study (PBTC 25B).

Author

Gajjar, Amar J., primary, Gururangan, Sridharan, additional, Qaddoumi, Ibrahim A, additional, Packer, Roger, additional, Goldman, Stewart, additional, Prados, Michael, additional, Desjardins, Annick, additional, Fouladi, Maryam, additional, Takebe, Naoko, additional, Li, Shaoyi, additional, Ellison, David W., additional, Curran, Tom, additional, Gilbertson, Richard J., additional, and Boyett, James M., additional

Published
2013
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238. Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology.

Author

Qaddoumi, Ibrahim, Orisme, Wilda, Wen, Ji, Santiago, Teresa, Gupta, Kirti, Dalton, James, Tang, Bo, Haupfear, Kelly, Punchihewa, Chandanamali, Easton, John, Mulder, Heather, Boggs, Kristy, Shao, Ying, Rusch, Michael, Becksfort, Jared, Gupta, Pankaj, Wang, Shuoguo, Lee, Ryan, Brat, Daniel, and Peter Collins, V.

Subjects
*BRAF genes, *FIBROBLAST growth factor receptors, *MYB gene, *ASTROCYTOMAS, *GENETICS, EPITHELIAL cell tumors
Abstract

Low-grade neuroepithelial tumors (LGNTs) are diverse CNS tumors presenting in children and young adults, often with a history of epilepsy. While the genetic profiles of common LGNTs, such as the pilocytic astrocytoma and 'adult-type' diffuse gliomas, are largely established, those of uncommon LGNTs remain to be defined. In this study, we have used massively parallel sequencing and various targeted molecular genetic approaches to study alterations in 91 LGNTs, mostly from children but including young adult patients. These tumors comprise dysembryoplastic neuroepithelial tumors (DNETs; n = 22), diffuse oligodendroglial tumors (d-OTs; n = 20), diffuse astrocytomas (DAs; n = 17), angiocentric gliomas ( n = 15), and gangliogliomas ( n = 17). Most LGNTs (84 %) analyzed by whole-genome sequencing (WGS) were characterized by a single driver genetic alteration. Alterations of FGFR1 occurred frequently in LGNTs composed of oligodendrocyte-like cells, being present in 82 % of DNETs and 40 % of d-OTs. In contrast, a MYB- QKI fusion characterized almost all angiocentric gliomas (87 %), and MYB fusion genes were the most common genetic alteration in DAs (41 %). A BRAF:p.V600E mutation was present in 35 % of gangliogliomas and 18 % of DAs. Pathogenic alterations in FGFR1/2/3, BRAF, or MYB/MYBL1 occurred in 78 % of the series. Adult-type d-OTs with an IDH1/2 mutation occurred in four adolescents, the youngest aged 15 years at biopsy. Despite a detailed analysis, novel genetic alterations were limited to two fusion genes, EWSR1- PATZ1 and SLMAP- NTRK2, both in gangliogliomas. Alterations in BRAF, FGFR1, or MYB account for most pathogenic alterations in LGNTs, including pilocytic astrocytomas, and alignment of these genetic alterations and cytologic features across LGNTs has diagnostic implications. Additionally, therapeutic options based upon targeting the effects of these alterations are already in clinical trials. [ABSTRACT FROM AUTHOR]

Published
2016
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239. DNA methylation analysis of paediatric lowgrade astrocytomas identifies a tumourspecific hypomethylation signature in pilocytic astrocytomas.

Author

Jeyapalan, Jennie N., Doctor, Gabriel T., Jones, Tania A., Alberman, Samuel N., Tep, Alexander, Haria, Chirag M., Schwalbe, Edward C., Morley, Isabel C. F., Hill, Alfred A., LeCain, Magdalena, Ottaviani, Diego, Clifford, Steven C., Qaddoumi, Ibrahim, Tatevossian, Ruth G., Ellison, David W., and Sheer, Denise

Subjects
GLIOMAS, ASTROCYTOMAS, DNA methylation, GENETICS
Abstract

Low-grade gliomas (LGGs) account for about a third of all brain tumours in children. We conducted a detailed study of DNA methylation and gene expression to improve our understanding of the biology of pilocytic and diffuse astrocytomas. Pilocytic astrocytomas were found to have a distinctive signature at 315 CpG sites, of which 312 were hypomethylated and 3 were hypermethylated. Genomic analysis revealed that 182 of these sites are within annotated enhancers. The signature was not present in diffuse astrocytomas, or in published profiles of other brain tumours and normal brain tissue. The AP-1 transcription factor was predicted to bind within 200 bp of a subset of the 315 differentially methylated CpG sites; the AP-1 factors, FOS and FOSL1 were found to be up-regulated in pilocytic astrocytomas. We also analysed splice variants of the AP-1 target gene, CCND1, which encodes cell cycle regulator cyclin D1. CCND1a was found to be highly expressed in both pilocytic and diffuse astrocytomas, but diffuse astrocytomas have far higher expression of the oncogenic variant, CCND1b. These findings highlight novel genetic and epigenetic differences between pilocytic and diffuse astrocytoma, in addition to well-described alterations involving BRAF, MYB and FGFR1. [ABSTRACT FROM AUTHOR]

Published
2016
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240. Management and outcome of focal low-grade brainstem tumors in pediatric patients: the St. Jude experience

Author

Klimo, Paul, primary, Pai Panandiker, Atmaram S., additional, Thompson, Clinton J., additional, Boop, Frederick A., additional, Qaddoumi, Ibrahim, additional, Gajjar, Amar, additional, Armstrong, Gregory T., additional, Ellison, David W., additional, Kun, Larry E., additional, Ogg, Robert J., additional, and Sanford, Robert A., additional

Published
2013
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245. Practical steps for establishing ocular plaque therapy in developing countries

Author

Jaradat, Imad, primary, Mula-Hussain, Layth, additional, Wadi-Ramahi, Shada, additional, Al-Mousa, Abdelatif, additional, Salem, Ahmed, additional, Haddadin, Inad, additional, Meheyar, Mustafa, additional, Kharma, Saamir, additional, Rawashdeh, Khaleel, additional, Sultan, Iyad, additional, Abdeen, Ghadeer, additional, Qaddoumi, Ibrahim, additional, and Nawaiseh, Ibrahim, additional

Published
2012
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246. Topotecan and vincristine combination is effective against advanced bilateral intraocular retinoblastoma and has manageable toxicity

Author

Qaddoumi, Ibrahim, primary, Billups, Catherine A., additional, Tagen, Michael, additional, Stewart, Clinton F., additional, Wu, Jianrong, additional, Helton, Kathleen, additional, McCarville, M. Beth, additional, Merchant, Thomas E., additional, Brennan, Rachel, additional, Free, Tammy M., additional, Given, Vicki, additional, Haik, Barrett G., additional, Rodriguez-Galindo, Carlos, additional, and Wilson, Matthew W., additional

Published
2012
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250. Chromosome arm 1q gain is an adverse prognostic factor in localized and diffuse leptomeningeal glioneuronal tumors with BRAF gene fusion and 1p deletion.

Author

Chiang, Jason, Dalton, James, Upadhyaya, Santhosh A., Patay, Zoltán, Qaddoumi, Ibrahim, Li, Xiaoyu, Segura, Annette D., Sharma, Suash, Ismail, Azzam, Shurtleff, Sheila A., and Raimondi, Susana C.

Subjects
BRAF genes, GLIOMAS, HUMAN deletion mutation
Abstract

The article presents case studies of localized spinal BRAF-fused and 1p-deleted glioneuronal tumors in which one of the patients at St. Jude Children's Research Hospital in Tennessee developed diffuse leptomeningeal dissemination involving spinal, posterior fossa, and supratentorial components.

Published
2019
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