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203. Molecular Diagnostics in Bone Marrow Haematopathology

Author

Per Levéen, Anna Porwit, and Mats Ehinger

Subjects
chemistry.chemical_compound, Real-time polymerase chain reaction, medicine.anatomical_structure, chemistry, medicine, RNA, %22">Fish , Bone marrow, Biology, Molecular diagnostics, Molecular biology, DNA
Published
2020

204. First measurement of the charged current <math><msub><mover><mi>ν</mi><mo>¯</mo></mover><mi>μ</mi></msub></math> double differential cross section on a water target without pions in the final state

Author

Abe, K., Akutsu, R., Ali, A., Alt, C., Andreopoulos, C., Anthony, L., Antonova, M., Aoki, S., Ariga, A., Ashida, Y., Atkin, E. T., Awataguchi, Y., Ban, S., Barbi, M., Barker, G. J., Barr, G., Barry, C., Batkiewicz-Kwasniak, M., Beloshapkin, A., Bench, F., Berardi, V., Berkman, S., Berns, L., Bhadra, S., Bienstock, S., Blondel, A., Bolognesi, S., Bourguille, B., Boyd, S. B., Brailsford, D., Bravar, A., Bronner, C., Buizza Avanzini, M., Calcutt, J., Campbell, T., Cao, S., Cartwright, S. L., Catanesi, M. G., Cervera, A., Chappell, A., Checchia, C., Cherdack, D., Chikuma, N., Christodoulou, G., Coleman, J., Collazuol, G., Cook, L., Coplowe, D., Cudd, A., Dabrowska, A., De Rosa, G., Dealtry, T., Denner, P. F., Dennis, S. R., Densham, C., Di Lodovico, F., Dokania, N., Dolan, S., Drapier, O., Dumarchez, J., Dunne, P., Eklund, L., Emery-Schrenk, S., Ereditato, A., Fernandez, P., Feusels, T., Finch, A. J., Fiorentini, G. A., Fiorillo, G., Francois, C., Friend, M., Fujii, Y., Fujita, R., Fukuda, D., Fukuda, R., Fukuda, Y., Gameil, K., Giganti, C., Golan, T., Gonin, M., Gorin, A., Guigue, M., Hadley, D. R., Haigh, J. T., Hamacher-Baumann, P., Hartz, M., Hasegawa, T., Hastings, N. C., Hayashino, T., Hayato, Y., Hiramoto, A., Hogan, M., Holeczek, J., Hong Van, N. T., Iacob, F., Ichikawa, A. K., Ikeda, M., Ishida, T., Ishii, T., Ishitsuka, M., Iwamoto, K., Izmaylov, A., Jamieson, B., Jenkins, S. J., Jesús-Valls, C., Jiang, M., Johnson, S., Jonsson, P., Jung, C. K., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Karlen, D., Kataoka, Y., Katori, T., Kato, Y., Kearns, E., Khabibullin, M., Khotjantsev, A., Kim, H., Kim, J., King, S., Kisiel, J., Knight, A., Knox, A., Kobayashi, T., Koch, L., Koga, T., Konaka, A., Kormos, L. L., Koshio, Y., Kowalik, K., Kubo, H., Kudenko, Y., Kukita, N., Kurjata, R., Kutter, T., Kuze, M., Labarga, L., Lagoda, J., Lamoureux, M., Laveder, M., Lawe, M., Licciardi, M., Lindner, T., Litchfield, R. P., Liu, S. L., Li, X., Longhin, A., Ludovici, L., Lu, X., Lux, T., Magaletti, L., Mahn, K., Malek, M., Manly, S., Maret, L., Marino, A. D., Martin, J. F., Maruyama, T., Matsubara, T., Matsushita, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCarthy, M., McCauley, N., McFarland, K. S., McGrew, C., Mefodiev, A., Metelko, C., Mezzetto, M., Minamino, A., Mineev, O., Mine, S., Miura, M., Molina Bueno, L., Moriyama, S., Morrison, J., Mueller, Th. A., Munteanu, L., Murphy, S., Nagai, Y., Nakadaira, T., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, K. G., Nakamura, K., Nakayama, S., Nakaya, T., Nakayoshi, K., Nantais, C., Ngoc, T. V., Niewczas, K., Nishikawa, K., Nishimura, Y., Nonnenmacher, T. S., Nova, F., Novella, P., Nowak, J., Nugent, J. C., O’Keeffe, H. M., O’Sullivan, L., Okumura, K., Okusawa, T., Oser, S. M., Owen, R. A., Oyama, Y., Palladino, V., Palomino, J. L., Paolone, V., Parker, W. C., Paudyal, P., Pavin, M., Payne, D., Penn, G. C., Pickering, L., Pidcott, C., Pinzon Guerra, E. S., Pistillo, C., Popov, B., Porwit, K., Posiadala-Zezula, M., Pritchard, A., Quilain, B., Radermacher, T., Radicioni, E., Radics, B., Ratoff, P. N., Reinherz-Aronis, E., Riccio, C., Rondio, E., Roth, S., Rubbia, A., Ruggeri, A. C., Rychter, A., Sakashita, K., Sánchez, F., Schloesser, C. M., Scholberg, K., Schwehr, J., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Sgalaberna, D., Shah, R., Shaikhiev, A., Shaker, F., Shaykina, A., Shiozawa, M., Shorrock, W., Shvartsman, A., Smirnov, A., Smy, M., Sobczyk, J. T., Sobel, H., Soler, F. J. P., Sonoda, Y., Steinmann, J., Suvorov, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sztuc, A. A., Tada, M., Takeda, A., Takeuchi, Y., Tanaka, H. K., Tanaka, H. A., Tanaka, S., Thompson, L. F., Toki, W., Touramanis, C., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Uno, W., Vagins, M., Valder, S., Vallari, Z., Vargas, D., Vasseur, G., Vilela, C., Vinning, W. G. S., Vladisavljevic, T., Volkov, V. V., Wachala, T., Walker, J., Walsh, J. G., Wang, Y., Wark, D., Wascko, M. O., Weber, A., Wendell, R., Wilking, M. J., Wilkinson, C., Wilson, J. R., Wilson, R. J., Wood, K., Wret, C., Yamada, Y., Yamamoto, K., Yanagisawa, C., Yang, G., Yano, T., Yasutome, K., Yen, S., Yershov, N., Yokoyama, M., Yoshida, T., Yu, M., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Ziembicki, M., Zimmerman, E. D., Zito, M., Zsoldos, S., and Zykova, A.

Abstract

This paper reports the first differential measurement of the charged-current ν¯μ interaction cross section on water with no pions in the final state. The unfolded flux-averaged measurement using the T2K off-axis near detector is given in double-differential bins of μ+ momentum and angle. The integrated cross section in a restricted phase space is σ=(1.11±0.18)×10−38 cm2 per water molecule. Comparisons with several nuclear models are also presented.

Published
2020

205. First measurement of the charged current ν¯μ double differential cross section on a water target without pions in the final state

Author

J. R. Wilson, Jochen Steinmann, T. Koga, D. Cherdack, S. Valder, C. McGrew, Y. Hayato, C. Andreopoulos, A. Longhin, A. Shaykina, T. Vladisavljevic, Yoshikazu Yamada, Thorsten Lux, M. Gonin, L. Molina Bueno, F. Bench, W. G. S. Vinning, E. Kearns, A. T. Suzuki, M. Pavin, S. J. Jenkins, T. V. Ngoc, A. Knox, J. F. Martin, C. Alt, T. Sekiguchi, T. Nakadaira, Hiroyuki Sekiya, F. Nova, T. Tsukamoto, Masashi Yokoyama, Yasunari Suzuki, Keigo Nakamura, R. Fujita, Y. Fukuda, Kendall Mahn, N. T. Hong Van, Hyun-Chul Kim, G. Christodoulou, J. Walker, Y. Takeuchi, Xianguo Lu, A. Mefodiev, K. Niewczas, L. H. V. Anthony, André Rubbia, S. Moriyama, Masayuki Nakahata, C. Pidcott, T. Ishida, Tsuyoshi Nakaya, J. L. Palomino, Y. Uchida, C. K. Jung, A. Cervera, L. Maret, M. Kabirnezhad, T. S. Nonnenmacher, Masato Shiozawa, C. Barry, S. Murphy, L. Ludovici, P. N. Ratoff, T. Kutter, T. Golan, A. Shvartsman, K. Zaremba, Yuki Fujii, S. Bhadra, L. Cook, R. Akutsu, M. Lamoureux, M. Friend, Teppei Katori, Pablo Fernandez, K. Kowalik, N. Chikuma, D. Vargas, C. Pistillo, Atsushi Takeda, J. Dumarchez, J. Schwehr, D. Brailsford, E. Reinherz-Aronis, G. Fiorillo, S. Bolognesi, B. Quilain, V. Palladino, M. M. Khabibullin, Yuichi Oyama, A. Shaikhiev, Alessandro Ruggeri, R.P. Kurjata, O. Drapier, Y. Nakajima, M. McCarthy, S. R. Dennis, S. Suvorov, R. P. Litchfield, C. M. Schloesser, S. Nakayama, J. T. Haigh, F. Di Lodovico, C. Wilkinson, M. Tada, D. J. Payne, Koji Yamamoto, M. Kuze, M. Mezzetto, N. C. Hastings, A. Zykova, K. Sakashita, S. M. Oser, L. Berns, A. Nakamura, L. Pickering, W. C. Parker, D. Coplowe, Yanbin Wang, Y. Nishimura, S. Manly, C. Riccio, K. Abe, Asher Kaboth, Y. Seiya, L. Magaletti, C. Giganti, Jan Kisiel, M. Tzanov, T. Okusawa, T. Kobayashi, J. A. Nowak, C. Yanagisawa, Jungsang Kim, S. Y. Suzuki, A. Chappell, Lars Eklund, Yuta Kato, C. J. Metelko, K. Matsushita, T. Hayashino, R. Fukuda, S. Berkman, M. Zito, Gareth J. Barker, A. Beloshapkin, E. T. Atkin, S. B. Boyd, T. Wachala, Artur F. Izmaylov, G. De Rosa, S. Ban, J. Calcutt, C. Vilela, T. Ishii, N. Dokania, G. A. Fiorentini, A. Konaka, L. Munteanu, Ahmed Ali, W. H. Toki, M. B. Smy, Xiao-yan Li, E. Mazzucato, Yusuke Koshio, F. Shaker, D. Karlen, S. L. Liu, E. Rondio, N. McCauley, C. M. Nantais, J. Morrison, A. Pritchard, K. Porwit, G. Zarnecki, C. Checchia, M. Buizza Avanzini, Vladimir Volkov, Lester D.R. Thompson, B. Jamieson, Shuji Tanaka, J. Holeczek, T. Radermacher, Thomas B. Campbell, K. Nakayoshi, M. Hogan, Yu. Kudenko, A. A. Sztuc, C. Densham, S. Zsoldos, Patrick Dunne, M. Vagins, M. Barbi, A. N. Khotjantsev, P. F. Denner, K. M. Tsui, N. Kukita, M. Licciardi, M. Lawe, H. W. Sobel, T. Feusels, T. Matsubara, K. Iwamoto, M. G. Catanesi, Marco Laveder, J. P. Coleman, A. Gorin, P. Hamacher-Baumann, Takaaki Kajita, K. Yasutome, A. Zalewska, Federico Sanchez, A. Bravar, Vincenzo Berardi, F. J. P. Soler, S. Bienstock, G. Vasseur, V. Paolone, Z. Vallari, K. Wood, E. D. Zimmerman, R. A. Wendell, T. Maruyama, G.D. Barr, S. V. Cao, M. J. Wilking, C. Touramanis, M. Jiang, Antonio Ereditato, N. Yershov, K. Gameil, A. Hiramoto, T. Hasegawa, A. Minamino, C. Jesús-Valls, G. C. Penn, T. Dealtry, K. Mavrokoridis, A. Dabrowska, M. Malek, A. J. Finch, J. Lagoda, H. A. Tanaka, R. J. Wilson, Akitaka Ariga, B. Bourguille, S. Dolan, T. Lindner, Shigeki Aoki, A. Cudd, M. Guigue, V. Matveev, J. C. Nugent, S. King, Y. Awataguchi, P. Paudyal, B. Radics, Alexei Yu. Smirnov, Hidekazu Kakuno, S. Mine, G. Yang, A. K. Ichikawa, K. Nishikawa, S. L. Cartwright, F. Iacob, Jan T. Sobczyk, M. Ziembicki, M. Ikeda, Kimihiro Okumura, S. Roth, J. Kameda, K. Nakamura, J. Zalipska, Hidetoshi Kubo, D. R. Hadley, C. Francois, A. C. Weber, Y. Nagai, Yousuke Kataoka, E. S. Pinzon Guerra, Th. A. Mueller, D. Fukuda, O. V. Mineev, M. Posiadala-Zezula, A. Knight, R. Shah, G. Collazuol, Mark Scott, J. G. Walsh, L. O'Sullivan, R. A. Owen, P. Novella, M. Batkiewicz-Kwasniak, H. M. O'Keeffe, M. Miura, C. Wret, L. Koch, B. A. Popov, L. L. Kormos, Masaki Ishitsuka, M. O. Wascko, M. Yu, C. Bronner, Kate Scholberg, T. Yoshida, Steven C. Johnson, S. Yen, K. S. McFarland, M. Antonova, M. Hartz, H. K. Tanaka, S. Emery-Schrenk, Yuto Ashida, D. Sgalaberna, A. Blondel, A. Rychter, W. Uno, E. Radicioni, D. L. Wark, W. Shorrock, T. Yano, A. D. Marino, Y. Sonoda, P. Jonsson, and L. Labarga

Subjects
Physics, Scattering cross-section, 010308 nuclear & particles physics, 0103 physical sciences, media_common.cataloged_instance, Library science, Christian ministry, Early career, European union, 010306 general physics, 01 natural sciences, media_common
Abstract

We thank the J-PARC staff for superb accelerator performance. We thank the CERN NA61/SHINE Collaboration for providing valuable particle production data. We acknowledge the support of MEXT, Japan; NSERC (Grant No. SAPPJ-2014-00031), the NRC and CFI, Canada; the CEA and CNRS/IN2P3, France; the DFG, Germany; the INFN, Italy; the National Science Centre and Ministry of Science and Higher Education, Poland; the RSF (Grant No. 19-12-00325) and the Ministry of Science and Higher Education, Russia; MINECO and ERDF funds, Spain; the SNSF and SERI, Switzerland; the STFC, UK; and the DOE, USA. We also thank CERN for the UA1/NOMAD magnet, DESY for the HERA-B magnet mover system, NII for SINET4, the WestGrid and SciNet consortia in Compute Canada, and GridPP in the United Kingdom. In addition, participation of individual researchers and institutions has been further supported by funds from the ERC (FP7), “la Caixa” Foundation (ID 100010434, fellowship code LCF/BQ/IN17/11620050), the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska- Curie Grants Agreement No. 713673 and No. 754496, and H2020 Grant No. RISE-GA822070-JENNIFER2 2020 and No. RISE-GA872549-SK2HK; the JSPS, Japan; the Royal Society, UK; French ANR Grant No. ANR-19- CE31-0001; and the DOE Early Career programme, USA.

Published
2020

206. Singular values as neutrino mixing quantifiers

Author

Flieger, Wojciech, Gluza, Janusz, and Porwit, Kamil

Subjects
High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

The neutrino mixing matrix is characterized by singular values and contractions. The method of unitary dilation is introduced to extend 3-dimensional mixing matrices to a full unitary matrix. The minimal dimension of such an extension is not arbitrary but depends on singular values. It means that singular values encode information about the number of additional neutrinos. Taking this into account, scenarios with a different number of additional, non-standard neutrinos are investigated. For the 3+1 scenario (one additional neutrino) analytical formula for the light-heavy mixing between SM-active and a right-handed neutrino as a function of singular values is derived. New stringent bounds on light-heavy mixings are established. In particular, in a seesaw mass scheme with one heavy sterile neutrino, the upper bounds on active-sterile neutrino mixings are even two times stringent than so far.

Published
2020
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207. A study of 3+N neutrino scenarios through singular values

Author

Porwit, Kamil, Flieger, Wojciech, and J. Gluza

Subjects
PMNS matrix, Neutrino, Contractions, Mixing matrix
Abstract

The Standard Model is based on three neutrino flavours where neutrinos mix by unitary matrix PMNS. However, there can exist additional number of neutrinos hidden within our mathematical and experimental benightedness. We propose an independent analysis of neutrino mixing data based on interval matrices. Methods of matrix analysis show that the set of physically admissible mixing matrices are classified as contractions lying within the convex hull of the experimentally determined PMNS matrices. Moreover, it appears that the number of additional neutrinos is controlled by the singular values of mixing matrices. In this way the method can be used to test the Standard Model as well as its extensions. This work applies the procedure of construction of 3-dimensional mixing matrices as contractions with prescribed number of additional neutrinos that agree with experimental measurements. Considered scenarios are one and two additional neutrinos with three different masses. For both scenarios matrices which are contractions and has prescribed singular values were constructed. Further these matrices can be extended to assumed dimension via the procedure of the unitary dilation.

Published
2020
Full Text
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208. Measurement of the muon neutrino charged-current single π+ production on hydrocarbon using the T2K off-axis near detector ND280

Author

Rosario Castillo, B. A. Popov, Alexei Yu. Smirnov, K. Nishikawa, C. K. Jung, M. Ikeda, Masato Shiozawa, L. Ludovici, H. Kakuno, Kate Scholberg, L. Zambelli, Jan T. Sobczyk, S. Bhadra, M. Antonova, D. Hansen, T. Feusels, P. Novella, M. M. Khabibullin, J. C. Nugent, O. Drapier, S. King, E. Kearns, W. G. S. Vinning, M. McCarthy, Masashi Yokoyama, W. Shorrock, N. T. Hong Van, J. Walker, T. V. Ngoc, A. Mefodiev, C. Francois, K. Mavrokoridis, D. R. Hadley, T. Ishida, Tsuyoshi Nakaya, A. D. Marino, A. Hiramoto, T. Hasegawa, S. Tobayama, T. Lou, M. Lawe, J. Harada, H. W. Sobel, J. T. Haigh, Ryuji Tamura, F. Iacob, Gareth J. Barker, F. Nova, A. Shaikhiev, R. G. Calland, S. Bordoni, S. Yamasu, J. Holeczek, T. Radermacher, Thomas B. Campbell, K. Nakamura, P. Hamacher-Baumann, J. P. Coleman, K. Nakayoshi, L. Molina Bueno, A. T. Suzuki, F. Gizzarelli, F. Shaker, T. Tomura, B. Quilain, Vincenzo Berardi, A. Zalewska, Y. Nagai, J. F. Martin, N. D. Patel, F. J. P. Soler, Marco Laveder, T. Nakadaira, S. Valder, T. Shirahige, E. Radicioni, M. Ziembicki, J. Zalipska, J. Insler, F. Sanchez, Shin Sasaki, R. M. Berner, Yufeng Wang, K. Sakashita, S. M. Oser, S. Bienstock, J. L. Palomino, G. Vasseur, L. Berns, M. Posiadala-Zezula, T. Inoue, S. Zsoldos, T.S. Nonnenmacher, A. Ali, K. Iwamoto, Y. Nishimura, D. Shaw, W. H. Toki, Y. Takeuchi, A. Blondel, A. Rychter, Y. Kataoka, Akitaka Ariga, Ko Okumura, L. Pickering, G. Fiorillo, M. Hartz, M. Barbi, Alyssa Garcia, B. Bourguille, T. Kajita, K. Zaremba, P. Stowell, S. Mine, K. M. Tsui, Shigeki Aoki, C. Alt, Yutaka Nakajima, D. Karlen, Atsushi Takeda, G. Yang, S. V. Cao, L. Maret, K. Yasutome, Yoshihiro Suzuki, V. Matveev, A. Bravar, S. L. Liu, P. N. Ratoff, Alessandro Ruggeri, N. Kukita, M. Licciardi, W. Uno, M. Lamoureux, T. Thakore, T. Kutter, T. Matsubara, Hidetoshi Kubo, A. C. Weber, C. Touramanis, M. Friend, M. Jiang, Antonio Ereditato, N. Yershov, Y. Petrov, C. Wilkinson, T. Maruyama, S. Ban, T. Wachala, K. Kowalik, Teppei Katori, M. Hogan, G.D. Barr, G. Collazuol, N. Chikuma, Mark Scott, S. Berkman, T. Ishii, N. Dokania, P. P. Koller, A. Minamino, S. Bolognesi, C. Jesús-Valls, N. McCauley, M. Malek, J. Morrison, T. Golan, V. Paolone, T. Yano, Yoshikazu Yamada, Z. J. Liptak, Y. Awataguchi, Z. Vallari, C. W. Walter, Patrick Dunne, A. Shvartsman, W. Y. Ma, H. J. Kim, A. Pritchard, Yuki Fujii, A. N. Khotjantsev, E. D. Zimmerman, S. J. Jenkins, Todd D. Stewart, M. J. Wilking, Pablo Fernandez, D. Vargas, M. A. M. Rayner, G. Zarnecki, P. F. Denner, A. Knox, J. Dumarchez, J. Schwehr, T. Sekiguchi, M. Buizza Avanzini, Hiroyuki Sekiya, R. Fujita, F. Bench, C. Pistillo, B. Jamieson, Y. Fukuda, Kendall Mahn, Keigo Nakamura, D. Coplowe, D. Brailsford, K. Gameil, Y. Sonoda, C. J. Densham, L. Cook, I. Lamont, A. Cervera, C. Nielsen, M. Kabirnezhad, G. C. Penn, T. Hayashino, R. Fukuda, A. Dabrowska, S. R. Dennis, T. Koga, Per Jönsson, C. M. Schloesser, Shuji Tanaka, Davide Sgalaberna, T. Okusawa, R. Akutsu, Y. Seiya, D. Cherdack, M. R. Vagins, S. Y. Suzuki, K. Abe, C. McGrew, S. Dolan, T. Lindner, L. Koch, Y. Hayato, C. Andreopoulos, A. Cudd, A. C. Kaboth, T. Vladisavljevic, J. Y. Kim, E. Mazzucato, Thorsten Lux, Seiko Hirota, M. Gonin, Y. Ashida, W. Oryszczak, K. S. Wood, G. Christodoulou, M. Mezzetto, M. Zito, Y. Nakanishi, S. Moriyama, Yuichi Oyama, S. Suvorov, R. P. Litchfield, Masayuki Nakahata, C. Pidcott, Y. Uchida, M. Tzanov, C. J. Metelko, A. Longhin, A. Shaykina, Giovanni Fiorentini, K. Matsushita, Yu. Kudenko, E. T. Atkin, A. Beloshapkin, R. A. Intonti, G. De Rosa, Koji Yamamoto, M. Pavin, J. Calcutt, Masaki Ishitsuka, A. Konaka, L. Munteanu, Yusuke Koshio, Leïla Haegel, Takahiro Hiraki, O. V. Mineev, James R. Wilson, Yusuke Suda, C. Vilela, R. Shah, E. Rondio, R. A. Owen, A. Gorin, M. Batkiewicz-Kwasniak, M. Miura, C. Wret, C. M. Nantais, K. E. Duffy, H.A. Tanaka, S. Murphy, Xianguo Lu, M. Yu, J. M. Poutissou, C. Bronner, K. Niewczas, M. Guigue, P. Paudyal, J. Walsh, J. P. Lopez, J. Imber, L. H. V. Anthony, André Rubbia, S. L. Cartwright, K. Huang, K. Porwit, S. Manly, Xiao-yan Li, L. L. Kormos, W. Parker, P. Przewlocki, P. Lasorak, S. Martynenko, David A. Wark, J. Lagoda, R. J. Wilson, C. Checchia, Vladimir Volkov, A. Nakamura, Lester D.R. Thompson, R. Tacik, D. Fukuda, C. Riccio, M. G. Catanesi, L. O'Sullivan, T. Yoshida, K. S. McFarland, Jan Kisiel, L. Labarga, T. Kobayashi, H. K. Tanaka, A. Zykova, J. Amey, Alexander Finch, T. Dealtry, A. Missert, B. Radics, P. Martins, F. Di Lodovico, M. Tada, D. J. Payne, M. Kuze, N. C. Hastings, Steven C. Johnson, S. Nakayama, R. A. Wendell, S. Yen, S. Emery-Schrenk, T. Tsukamoto, A. K. Ichikawa, S. Roth, J. Kameda, Y. Azuma, E. S. Pinzon Guerra, Th. A. Mueller, A. Knight, J. Steinmann, H. M. O'Keeffe, T. Ovsyannikova, M. O. Wascko, C. Barry, B. Rossi, C. Yanagisawa, L. Magaletti, C. Giganti, V. Palladino, J. A. Nowak, E. Iwai, A. Chappell, A. A. Sztuc, E. Reinherz-Aronis, E. Scantamburlo, R.P. Kurjata, F. Hosomi, M. B. Smy, Lars Eklund, Yuta Kato, A. Hillairet, L. N. Machado, S. B. Boyd, and Artur F. Izmaylov

Subjects
Physics, Muon, Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, 7. Clean energy, 01 natural sciences, Nuclear physics, Cross section (physics), Pion, 0103 physical sciences, High Energy Physics::Experiment, Muon neutrino, Production (computer science), Neutrino, Nuclear Experiment, 010306 general physics, Nucleon, Charged current
Abstract

We report the measurements of single and double differential cross section of muon neutrino charged-current interactions on carbon with a single positively charged pion in the final state at the T2K off-axis near detector using $5.56\times10^{20}$ protons on target. The analysis uses data control samples for the background subtraction and the cross section signal, defined as a single negatively charged muon and a single positively charged pion exiting from the target nucleus, is extracted using an unfolding method. The model dependent cross section, integrated over the T2K off-axis neutrino beam spectrum peaking at $0.6$~GeV, is measured to be $\sigma = (11.76 \pm 0.44 \text{(stat)} \pm 2.39 \text{(syst)}) \times 10^{-40} \text{cm}^2$~$\text{nucleon}^{-1}$. Various differential cross sections are measured, including the first measurement of the Adler angles for single charged pion production in neutrino interactions with heavy nuclei target.

Published
2020

209. Measurement of the muon neutrino charged-current single π+ production on hydrocarbon using the T2K off-axis near detector ND280

Author

Abe, K., Akutsu, R., Ali, A., Alt, C., Amey, J., Andreopoulos, C., Holeczek, Jacek, Kisiel, Jan, and Porwit, Kamil

Subjects
muon neutrino
Abstract

Authors: K. Abe,55 R. Akutsu,56 A. Ali,32 C. Alt,11 J. Amey,21 C. Andreopoulos,53,34 L. Anthony,34 M. Antonova,19 S. Aoki,31 A. Ariga,2 Y. Ashida,32 E. T. Atkin,21 Y. Awataguchi,58 Y. Azuma,41 S. Ban,32 M. Barbi,45 G. J. Barker,65 G. Barr,42 C. Barry,34 M. Batkiewicz-Kwasniak,15 A. Beloshapkin,26 F. Bench,34 V. Berardi,22 S. Berkman,4,61 R. M. Berner,2 L. Berns,57 S. Bhadra,69 S. Bienstock,52 A. Blondel,13,† S. Bolognesi,6 S. Bordoni,18,† B. Bourguille,18 S. B. Boyd,65 D. Brailsford,33 A. Bravar,13 C. Bronner,55 M. Buizza Avanzini,10 J. Calcutt,36 R. G. Calland,28 T. Campbell,7 S. Cao,16 S. L. Cartwright,49 R. Castillo,18,‡ M. G. Catanesi,22 A. Cervera,19 A. Chappell,65 C. Checchia,24 D. Cherdack,17 N. Chikuma,54 G. Christodoulou,12 J. Coleman,34 G. Collazuol,24 L. Cook,42,28 D. Coplowe,42 A. Cudd,36 A. Dabrowska,15 G. De Rosa,23 T. Dealtry,33 P. F. Denner,65 S. R. Dennis,34 C. Densham,53 F. Di Lodovico,30 N. Dokania,39 S. Dolan,12 O. Drapier,10 K. E. Duffy,42 J. Dumarchez,52 P. Dunne,21 L. Eklund,14 S. Emery-Schrenk,6 A. Ereditato,2 P. Fernandez,19 T. Feusels,4,61 A. J. Finch,33 G. A. Fiorentini,69 G. Fiorillo,23 C. Francois,2 M. Friend,16,§ Y. Fujii,16,§ R. Fujita,54 D. Fukuda,40 R. Fukuda,59 Y. Fukuda,37 K. Gameil,4,61 A. Garcia,18 C. Giganti,52 F. Gizzarelli,6 T. Golan,67 M. Gonin,10 A. Gorin,26 M. Guigue,52 D. R. Hadley,65 L. Haegel,13 J. T. Haigh,65 P. Hamacher-Baumann,48 D. Hansen,43 J. Harada,41 M. Hartz,61,28 T. Hasegawa,16,§ N. C. Hastings,16 T. Hayashino,32 Y. Hayato,55,28 A. Hillairet,62 T. Hiraki,32 A. Hiramoto,32 S. Hirota,32 M. Hogan,8 J. Holeczek,50 N. T. Hong Van,20,27 F. Hosomi,54 K. Huang,32 F. Iacob,24 A. K. Ichikawa,32 M. Ikeda,55 J. Imber,10 T. Inoue,41 J. Insler,35 R. A. Intonti,22 T. Ishida,16,§ T. Ishii,16,§ M. Ishitsuka,59 E. Iwai,16 K. Iwamoto,54 A. Izmaylov,19,26 B. Jamieson,66 S. J. Jenkins,49 C. Jesús-Valls,18 M. Jiang,32 S. Johnson,7 P. Jonsson,21 C. K. Jung,39,∥ M. Kabirnezhad,42 A. C. Kaboth,47,53 T. Kajita,56,∥ H. Kakuno,58 J. Kameda,55 D. Karlen,62,61 Y. Kataoka,55 T. Katori,30 Y. Kato,55 E. Kearns,3,28,∥ M. Khabibullin,26 A. Khotjantsev,26 H. Kim,41 J. Kim,4,61 S. King,44 J. Kisiel,50 A. Knight,65 A. Knox,33 T. Kobayashi,16,§ L. Koch,53 T. Koga,54 P. P. Koller,2 A. Konaka,61 L. L. Kormos,33 Y. Koshio,40,∥ K. Kowalik,38 H. Kubo,32 Y. Kudenko,26,¶ N. Kukita,41 R. Kurjata,64 T. Kutter,35 M. Kuze,57 L. Labarga,1 J. Lagoda,38 I. Lamont,33 M. Lamoureux,24 P. Lasorak,44 M. Laveder,24 M. Lawe,33 M. Licciardi,10 T. Lindner,61 Z. J. Liptak,7 R. P. Litchfield,14 S. L. Liu,39 X. Li,39 A. Longhin,24 J. P. Lopez,7 T. Lou,54 L. Ludovici,25 X. Lu,42 T. Lux,18 L. N. Machado,23 L. Magaletti,22 K. Mahn,36 M. Malek,49 S. Manly,46 L. Maret,13 A. D. Marino,7 J. F. Martin,60 P. Martins,44 S. Martynenko,39 T. Maruyama,16,§ T. Matsubara,16 K. Matsushita,54 V. Matveev,26 K. Mavrokoridis,34 W. Y. Ma,21 E. Mazzucato,6 M. McCarthy,69 N. McCauley,34 K. S. McFarland,46 C. McGrew,39 A. Mefodiev,26 C. Metelko,34 M. Mezzetto,24 A. Minamino,68 O. Mineev,26 S. Mine,5 A. Missert,7 M. Miura,55,∥ L. Molina Bueno,11 S. Moriyama,55,∥ J. Morrison,36 Th. A. Mueller,10 L. Munteanu,6 S. Murphy,11 Y. Nagai,7 T. Nakadaira,16,§ M. Nakahata,55,28 Y. Nakajima,55 A. Nakamura,40 K. G. Nakamura,32 K. Nakamura,28,16,§ K. D. Nakamura,32 Y. Nakanishi,32 S. Nakayama,55,28 T. Nakaya,32,28 K. Nakayoshi,16,§ C. Nantais,60 T. V. Ngoc,20 C. Nielsen,4,61 K. Niewczas,67 K. Nishikawa,16,* Y. Nishimura,29 T. S. Nonnenmacher,21 F. Nova,53 P. Novella,19 J. Nowak,33 J. C. Nugent,14 H. M. O’Keeffe,33 L. O’Sullivan,49 K. Okumura,56,28 T. Okusawa,41 W. Oryszczak,63 S. M. Oser,4,61 T. Ovsyannikova,26 R. A. Owen,44 Y. Oyama,16,§ V. Palladino,23 J. L. Palomino,39 V. Paolone,43 W. C. Parker,47 N. D. Patel,32 P. Paudyal,34 M. Pavin,61 D. Payne,34 G. C. Penn,34 Y. Petrov,4,61 L. Pickering,36 C. Pidcott,49 E. S. Pinzon Guerra,69 C. Pistillo,2 B. Popov,52,** K. Porwit,50 M. Posiadala-Zezula,63 J.-M. Poutissou,61 A. Pritchard,34 P. Przewlocki,38 B. Quilain,28 T. Radermacher,48 E. Radicioni,22 B. Radics,11 P. N. Ratoff,33 M. A. Rayner,13 E. Reinherz-Aronis,8 C. Riccio,23 E. Rondio,38 B. Rossi,23 S. Roth,48 A. Rubbia,11 A. C. Ruggeri,23 A. Rychter,64 K. Sakashita,16,§ F. Sánchez ,13 S. Sasaki,58 E. Scantamburlo,13 C. M. Schloesser,11 K. Scholberg,9,∥ J. Schwehr,8 M. Scott,21 Y. Seiya,41,†† T. Sekiguchi,16,§ H. Sekiya,55,28,∥ D. Sgalaberna,12 R. Shah,53,42 A. Shaikhiev,26 F. Shaker,66 D. Shaw,33 A. Shaykina,26 M. Shiozawa,55,28 T. Shirahige,40 W. Shorrock,21 A. Shvartsman,26 A. Smirnov,26 M. Smy,5 J. T. Sobczyk,67 H. Sobel,5,28 F. J. P. Soler,14 Y. Sonoda,55 J. Steinmann,48 T. Stewart,53 P. Stowell,49 Y. Suda,54 S. Suvorov,26,6 A. Suzuki,31 S. Y. Suzuki,16,§ Y. Suzuki,28 A. A. Sztuc,21 R. Tacik,45,61 M. Tada,16,§ A. Takeda,55 Y. Takeuchi,31,28 R. Tamura,54 H. K. Tanaka,55,∥ H. A. Tanaka,51,60 S. Tanaka,41 T. Thakore,35 L. F. Thompson,49 S. Tobayama,4,61 W. Toki,8 T. Tomura,55 C. Touramanis,34 K. M. Tsui,34 T. Tsukamoto,16,§ M. Tzanov,35 Y. Uchida,21 W. Uno,32 M. Vagins,28,5 S. Valder,65 Z. Vallari,39 D. Vargas,18 G. Vasseur,6 C. Vilela,39 W. G. S. Vinning,65 T. Vladisavljevic,42,28 V. V. Volkov,26 T. Wachala,15 J. Walker,66 J. G. Walsh,33 C.W. Walter,9,∥ Y. Wang,39 D. Wark,53,42 M. O. Wascko,21 A. Weber,53,42 R. Wendell,32,∥ M. J. Wilking,39 C. Wilkinson,2 J. R. Wilson,30 R. J. Wilson,8 K. Wood,39 C. Wret,46 Y. Yamada,16,* K. Yamamoto,41,†† S. Yamasu,40 C. Yanagisawa,39,‡‡ G. Yang,39 T. Yano,55 K. Yasutome,32 S. Yen,61 N. Yershov,26 M. Yokoyama,54,∥ T. Yoshida,57 M. Yu,69 A. Zalewska,15 J. Zalipska,38 L. Zambelli,16,§ K. Zaremba,64 G. Zarnecki,38 M. Ziembicki,64 E. D. Zimmerman,7 M. Zito,6 S. Zsoldos,44 and A. Zykova26 (The T2K Collaboration), We report the measurements of the single and double differential cross section of muon neutrino charged-current interactions on carbon with a single positively charged pion in the final state at the T2K offaxis near detector using 5.56 × 1020 protons on target. The analysis uses data control samples for the background subtraction and the cross section signal, defined as a single negatively charged muon and a single positively charged pion exiting from the target nucleus, is extracted using an unfolding method. The model-dependent cross section, integrated over the T2K off-axis neutrino beam spectrum peaking at 0.6 GeV, is measured to be σ ¼ ð11.76 0.44ðstatÞ 2.39ðsystÞÞ × 10−40 cm2 nucleon−1. Various differential cross sections are measured, including the first measurement of the Adler angles for single charged pion production in neutrino interactions with heavy nuclei target.

Published
2020

210. First measurement of the charged current (nu)over-bar(mu) double differential cross section on a water target without pions in the final state : (The T2K Collaboration)

Author

Abe, K., Akutsu, R., Ali, A., Alt, C., Andreopoulos, C., Anthony, L., Antonova, M., Aoki, S., Ariga, A., Ashida, Y., Atkin, E. T., Iwamoto, K., Izmaylov, A., Jamieson, B., Jenkins, S. J., Jesús-Valls, C., Jiang, M., Johnson, S., Jonsson, P., Jung, C. K., Kabirnezhad, M., Awataguchi, Y., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Karlen, D., Kataoka, Y., Katori, T., Kato, Y., Kearns, E., Khabibullin, M., Ban, S., Khotjantsev, A., Kim, H., Kim, J., King, S., Kisiel, Jan, Knight, A., Knox, A., Kobayashi, T., Koch, L., Koga, T., Barbi, M., Konaka, A., Kormos, L.L., Koshio, Y., Kowalik, K., Kubo, H., Kudenko, Y., Kukita, N., Kurjata, R., Kutter, T., Kuze, M., Barker, G. J., Labarga, L., Lagoda, J., Lamoureux, M., Laveder, M., Lawe, M., Licciardi, M., Lindner, T., Litchfield, R. P., Liu, S. L., Li, X., Barr, G., Longhin, A., Ludovici, L., Lu, X., Lux, T., Magaletti, L., Mahn, K., Malek, M., Manly, S., Maret, L., Marino, A. D., Barry, C., Martin, J. F., Maruyama, T., Matsubara, T., Matsushita, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCarthy, M., McCauley, N., McFarland, K. S., Batkiewicz-Kwasniak, M., McGrew, C., Mefodiev, A., Metelko, C., Mezzetto, M., Minamino, A., Mineev, O., Mine, S., Miura, M., Molina Bueno, L., Moriyama, S., Beloshapkin, A., Morrison, J., Mueller, Th. A., Munteanu, L., Murphy, S., Nagai, Y., Nakadaira, T., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, K. G., Bench, F., Nakamura, K., Nakayama, S., Nakaya, T., Nakayoshi, K., Nantais, C., Ngoc, T. V., Niewczas, K., Nishikawa, K., Nishimura, Y., Nonnenmacher, T. S., Berardi, V., Nova, F., Novella, P., Nowak, J., Nugent, J. C., O’Keeffe, H. M., O’Sullivan, L., Okumura, K., Okusawa, T., Oser, S. M., Owen, R. A., Berkman, S., Oyama, Y., Palladino, V., Palomino, J.L., Paolone, V., Parker, W.C., Paudyal, P., Pavin, M., Payne, D., Penn, G. C., Pickering, L., Berns, L., Pidcott, C., Pinzon Guerra, E. S., Pistillo, C., Popov, B., Porwit, Kamil, Posiadala-Zezula, M., Pritchard, A., Quilain, B., Radermacher, T., Radicioni, E., Bhadra, S., Radics, B., Ratoff, P. N., Reinherz-Aronis, E., Riccio, C., Rondio, E., Roth, S., Rubbia, A., Ruggeri, A.C., Rychter, A., Sakashita, K., Bienstock, S., Sánchez, F., Schloesser, C. M., Scholberg, K., Schwehr, J., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Sgalaberna, D., Shah, R., Blondel, A., Shaikhiev, A., Shaker, F., Shaykina, A., Shiozawa, M., Shorrock, W., Shvartsman, A., Smirnov, A., Smy, M., Sobczyk, J.T., Sobel, H., Bolognesi, S., Soler, F.J.P., Sonoda, Y., Steinmann, J., Suvorov, S., Suzuki, A., Suzuki, S.Y., Suzuki, Y., Sztuc, A. A., Tada, M., Takeda, A., Bourguille, B., Takeuchi, Y., Tanaka, H. K., Tanaka, H. A., Tanaka, S., Thompson, L.F., Toki, W., Touramanis, C., Tsui, K. M., Tsukamoto, T., Tzanov, M., Boyd, S. B., Uchida, Y., Uno, W., Vagins, M., Valder, S., Vallari, Z., Vargas, D., Vasseur, G., Vilela, C., Vinning, W. G. S., T. Vladisavljevic, Brailsford, D., Volkov, V.V., Wachala, T., Walker, J., Walsh, J.G., Wang, Y., Wark, D., Wascko, M.O., Weber, A., Wendell, R., Wilking, M.J., Bravar, A., Wilkinson, C., Wilson, J.R., Wilson, R.J., Wood, K., Wret, C., Yamada, Y., Yamamoto, K., Yanagisawa, C., Yang, G., Yano, T., Bronner, C., Yasutome, K., Yen, S., Yershov, N., Yokoyama, M., Yoshida, T., Yu, M., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Buizza Avanzini, M., Ziembicki, M., Zimmerman, E.D., Zito, M., Zsoldos, S., Zykova, A., Calcutt, J., Campbell, T., Cao, S., Cartwright, S. L., Catanesi, M. G., Cervera, A., Chappell, A., Checchia, C., Cherdack, D., Chikuma, N., Christodoulou, G., Coleman, J., Collazuol, G., Cook, L., Coplowe, D., Cudd, A., Dabrowska, A., De Rosa, G., Dealtry, T., Denner, P. F., Dennis, S. R., Densham, C., Di Lodovico, F., Dokania, N., Dolan, S., Drapier, O., Dumarchez, J., Dunne, P., Eklund, L., Emery-Schrenk, S., Ereditato, A., Fernandez, P., Feusels, T., Finch, A. J., Fiorentini, G. A., Fiorillo, G., Francois, C., Friend, M., Fujii, Y., Fujita, R., Fukuda, D., Fukuda, R., Fukuda, Y., Gameil, K., Giganti, C., Golan, T., Gonin, M., Gorin, A., Guigue, M., Hadley, D. R., Haigh, J. T., Hamacher-Baumann, P., Hartz, M., Hasegawa, T., Hastings, N. C., Hayashino, T., Hayato, Y., Hiramoto, A., Hogan, M., Holeczek, Jacek, Hong Van, N. T., Iacob, F., Ichikawa, A. K., Ikeda, M., Ishida, T., Ishii, T., and Ishitsuka, M.

Subjects
neutrino, scattering, nuclei
Abstract

This paper reports the first differential measurement of the charged-current ¯νμ interaction cross section on water with no pions in the final state. The unfolded flux-averaged measurement using the T2K off-axis near detector is given in double-differential bins of μþ momentum and angle. The integrated cross section in a restricted phase space is σ ¼ ð1.11 0.18Þ × 10−38 cm2 per water molecule. Comparisons with several nuclear models are also presented.

Published
2020

211. First measurement of the charged current ν ¯ μ double differential cross section on a water target without pions in the final state FIRST MEASUREMENT of the CHARGED CURRENT ... ABE K. et al

Author

Abe, K., Akutsu, R., Ali, A., Alt, C., Andreopoulos, C., Anthony, L., Antonova, M., Aoki, S., Ariga, A., Ashida, Y., Atkin, E. T., Awataguchi, Y., Ban, S., Barbi, M., Barker, G. J., Barr, G., Barry, C., Batkiewicz-Kwasniak, M., Beloshapkin, A., Bench, F., Berardi, V., Berkman, S., Berns, L., Bhadra, S., Bienstock, S., Blondel, A., Bolognesi, S., Bourguille, B., Boyd, S. B., Brailsford, D., Bravar, A., Bronner, C., Buizza Avanzini, M., Calcutt, J., Campbell, T., Cao, S., Cartwright, S. L., Catanesi, M. G., Cervera, A., Chappell, A., Checchia, C., Cherdack, D., Chikuma, N., Christodoulou, G., Coleman, J., Collazuol, G., Cook, L., Coplowe, D., Cudd, A., Dabrowska, A., De Rosa, G., Dealtry, T., Denner, P. F., Dennis, S. R., Densham, C., Di Lodovico, F., Dokania, N., Dolan, S., Drapier, O., Dumarchez, J., Dunne, P., Eklund, L., Emery-Schrenk, S., Ereditato, A., Fernandez, P., Feusels, T., Finch, A. J., Fiorentini, G. A., Fiorillo, G., Francois, C., Friend, M., Fujii, Y., Fujita, R., Fukuda, D., Fukuda, R., Fukuda, Y., Gameil, K., Giganti, C., Golan, T., Gonin, M., Gorin, A., Guigue, M., Hadley, D. R., Haigh, J. T., Hamacher-Baumann, P., Hartz, M., Hasegawa, T., Hastings, N. C., Hayashino, T., Hayato, Y., Hiramoto, A., Hogan, M., Holeczek, J., Hong Van, N. T., Iacob, F., Ichikawa, A. K., Ikeda, M., Ishida, T., Ishii, T., Ishitsuka, M., Iwamoto, K., Izmaylov, A., Jamieson, B., Jenkins, S. J., Jesus-Valls, C., Jiang, M., Johnson, S., Jonsson, P., Jung, C. K., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Karlen, D., Kataoka, Y., Katori, T., Kato, Y., Kearns, E., Khabibullin, M., Khotjantsev, A., Kim, H., Kim, J., King, S., Kisiel, J., Knight, A., Knox, A., Kobayashi, T., Koch, L., Koga, T., Konaka, A., Kormos, L. L., Koshio, Y., Kowalik, K., Kubo, H., Kudenko, Y., Kukita, N., Kurjata, R., Kutter, T., Kuze, M., Labarga, L., Lagoda, J., Lamoureux, M., Laveder, M., Lawe, M., Licciardi, M., Lindner, T., Litchfield, R. P., Liu, S. L., Li, X., Longhin, A., Ludovici, L., Lu, X., Lux, T., Magaletti, L., Mahn, K., Malek, M., Manly, S., Maret, L., Marino, A. D., Martin, J. F., Maruyama, T., Matsubara, T., Matsushita, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., Mccarthy, M., Mccauley, N., Mcfarland, K. S., Mcgrew, C., Mefodiev, A., Metelko, C., Mezzetto, M., Minamino, A., Mineev, O., Mine, S., Miura, M., Molina Bueno, L., Moriyama, S., Morrison, J., Mueller, T. A., Munteanu, L., Murphy, S., Nagai, Y., Nakadaira, T., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, K. G., Nakamura, K., Nakayama, S., Nakaya, T., Nakayoshi, K., Nantais, C., Ngoc, T. V., Niewczas, K., Nishikawa, K., Nishimura, Y., Nonnenmacher, T. S., Nova, F., Novella, P., Nowak, J., Nugent, J. C., O'Keeffe, H. M., O'Sullivan, L., Okumura, K., Okusawa, T., Oser, S. M., Owen, R. A., Oyama, Y., Palladino, V., Palomino, J. L., Paolone, V., Parker, W. C., Paudyal, P., Pavin, M., Payne, D., Penn, G. C., Pickering, L., Pidcott, C., Pinzon Guerra, E. S., Pistillo, C., Popov, B., Porwit, K., Posiadala-Zezula, M., Pritchard, A., Quilain, B., Radermacher, T., Radicioni, E., Radics, B., Ratoff, P. N., Reinherz-Aronis, E., Riccio, C., Rondio, E., Roth, S., Rubbia, A., Ruggeri, A. C., Rychter, A., Sakashita, K., Sanchez, F., Schloesser, C. M., Scholberg, K., Schwehr, J., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Sgalaberna, D., Shah, R., Shaikhiev, A., Shaker, F., Shaykina, A., Shiozawa, M., Shorrock, W., Shvartsman, A., Smirnov, A., Smy, M., Sobczyk, J. T., Sobel, H., Soler, F. J. P., Sonoda, Y., Steinmann, J., Suvorov, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sztuc, A. A., Tada, M., Takeda, A., Takeuchi, Y., Tanaka, H. K., Tanaka, H. A., Tanaka, S., Thompson, L. F., Toki, W., Touramanis, C., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Uno, W., Vagins, M., Valder, S., Vallari, Z., Vargas, D., Vasseur, G., Vilela, C., Vinning, W. G. S., Vladisavljevic, T., Volkov, V. V., Wachala, T., Walker, J., Walsh, J. G., Wang, Y., Wark, D., Wascko, M. O., Weber, A., Wendell, R., Wilking, M. J., Wilkinson, C., Wilson, J. R., Wilson, R. J., Wood, K., Wret, C., Yamada, Y., Yamamoto, K., Yanagisawa, C., Yang, G., Yano, T., Yasutome, K., Yen, S., Yershov, N., Yokoyama, M., Yoshida, T., Yu, M., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Ziembicki, M., Zimmerman, E. D., Zito, M., Zsoldos, S., and Zykova, A.

Subjects
High Energy Physics - Experiment
Published
2020

212. Ewolucja czy rewolucja? Imigracja z Ukrainy do aglomeracji warszawskiej z perspektywy lat 2015-2019

Author

Górny, Agata, Madej, Karolina, and Porwit, Katarzyna

Subjects
Warsaw, ddc:330, migration patterns, remittances, Ukrainian migrants, labour market
Abstract

The report demonstrates results of the survey on Ukrainian migrants in Warsaw agglomeration from 2019 against outcomes of the respective study conducted in 2015 and observations from earlier studies on other Polish cities: Bydgoszcz (2018), Lublin (2016), and Wroclaw (2018). It covers socio-demographic characteristics of migrants, their legal status, migration patterns and plans, situation on the labour market and practices related to savings and financial transfers. Its main conclusions demonstrate a still present specificity of Warsaw as the destination area in Poland, but refer also to gradual changes with regard to individual characteristics and behaviours of Ukrainian migrants on the Mazovian labour market in 2015-2019. These changes relate to decrease in feminisation and "rejuvenalisation" of Ukrainian migration - both in terms of migrants' age and migration experience - and also to growing role of migration from urban areas especially of Central Ukraine. Moreover, some growth in permanency of Ukrainian migration to Warsaw agglomeration can be observed: numbers of migrants' visits decrease, their mean duration prolongs, and the share of single migrants falls. As in other studied Polish cities, migrants, more often than in the past, leave Ukraine in search for better incomes and not due to lack of jobs. Although employment on the blue-collar positions, being below migrants' skills, still prevails, the selection of sectors in which Ukrainian migrants find jobs in Warsaw has been definitely diversifying. It can be also argued that financial situation of Ukrainian migrants in Mazovian region has been improving. However, growth in migrants' incomes and saving does not involve substantial changes in their remitting behaviours.

Published
2020

213. Multicenter validation of a reproducible flow cytometric score for the diagnosis of low-grade myelodysplastic syndromes: results of a European LeukemiaNET study

Author

Matteo G. Della Porta, Cristina Picone, Cristiana Pascutto, Luca Malcovati, Hideto Tamura, Hiroshi Handa, Magdalena Czader, Sylvie Freeman, Paresh Vyas, Anna Porwit, Leonie Saft, Theresia M. Westers, Canan Alhan, Claudia Cali, Arjan A. van de Loosdrecht, and Kiyoyuki Ogata

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Background The current World Health Organization classification of myelodysplastic syndromes is based morphological evaluation of bone marrow dysplasia. In clinical practice, the reproducibility of the recognition of dysplasia is usually poor especially in cases that lack specific markers such as ring sideroblasts and clonal cytogenetic abnormalities.Design and Methods We aimed to develop and validate a flow cytometric score for the diagnosis of myelodysplastic syndrome. Four reproducible parameters were analyzed: CD34+ myeloblast-related and B-progenitor-related cluster size (defined by CD45 expression and side scatter characteristics CD34+ marrow cells), myeloblast CD45 expression and granulocyte side scatter value. The study comprised a “learning cohort” (n=538) to define the score and a “validation cohort” (n=259) to confirm its diagnostic value.Results With respect to non-clonal cytopenias, patients with myelodysplastic syndrome had increased myeloblast-related cluster size, decreased B-progenitor-related cluster size, aberrant CD45 expression and reduced granulocyte side scatter (P

Published
2012
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217. p53 is associated with high-risk and pinpointsTP53missense mutations in mantle cell lymphoma

Author

Rodrigues, Joana M., Hassan, May, Freiburghaus, Catja, Eskelund, Christian W., Geisler, Christian, Raty, Riikka, Kolstad, Arne, Sundström, Christer, Glimelius, Ingrid, Gronbaek, Kirsten, Kwiecinska, Anna, Porwit, Anna, Jerkeman, Mats, Ek, Sara, Rodrigues, Joana M., Hassan, May, Freiburghaus, Catja, Eskelund, Christian W., Geisler, Christian, Raty, Riikka, Kolstad, Arne, Sundström, Christer, Glimelius, Ingrid, Gronbaek, Kirsten, Kwiecinska, Anna, Porwit, Anna, Jerkeman, Mats, and Ek, Sara

Abstract

Survival for patients diagnosed with mantle cell lymphoma (MCL) has improved drastically in recent years. However, patients carrying mutations in tumour protein p53 (TP53) do not benefit from modern chemotherapy-based treatments and have poor prognosis. Thus, there is a clinical need to identify missense mutations through routine analysis to enable patient stratification. Sequencing is not widely implemented in clinical practice for MCL, and immunohistochemistry (IHC) is a feasible alternative to identify high-risk patients. The aim of the present study was to investigate the accuracy of p53 as a tool to identify patients withTP53missense mutations and the prognostic impact of overexpression and mutations in a Swedish population-based cohort. In total, 317 cases were investigated using IHC and 255 cases were sequenced, enabling analysis of p53 andTP53status among 137 cases divided over the two-cohort investigated. The accuracy of predicting missense mutations from protein expression was 82%, with sensitivity at 82% and specificity at 100% in paired samples. We further show the impact of p53 expression andTP53mutations on survival (hazard ratio of 3 center dot 1 in univariate analysis for both), and the association to risk factors, such as high MCL International Prognostic Index, blastoid morphology and proliferation, in a population-based setting.

Published
2020
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218. Value of flow cytometry for MRD-based relapse prediction in B-cell precursor ALL in a multicenter setting

Author

Modvig, S., Hallböök, H., Madsen, H. O., Siitonen, S., Rosthøj, S., Tierens, A., Juvonen, V., Osnes, L. T. N., Vålerhaugen, H., Hultdin, Magnus, Matuzeviciene, R., Stoskus, M., Marincevic, M., Lilleorg, A., Ehinger, M., Norén-Nyström, Ulrika, Toft, N., Taskinen, M., Jónsson, O. G., Pruunsild, K., Vaitkeviciene, G., Vettenranta, K., Lund, B., Abrahamsson, J., Porwit, A., Schmiegelow, K., Marquart, H. V., Modvig, S., Hallböök, H., Madsen, H. O., Siitonen, S., Rosthøj, S., Tierens, A., Juvonen, V., Osnes, L. T. N., Vålerhaugen, H., Hultdin, Magnus, Matuzeviciene, R., Stoskus, M., Marincevic, M., Lilleorg, A., Ehinger, M., Norén-Nyström, Ulrika, Toft, N., Taskinen, M., Jónsson, O. G., Pruunsild, K., Vaitkeviciene, G., Vettenranta, K., Lund, B., Abrahamsson, J., Porwit, A., Schmiegelow, K., and Marquart, H. V.

Abstract

PCR of TCR/Ig gene rearrangements is considered the method of choice for minimal residual disease (MRD) quantification in BCP-ALL, but flow cytometry analysis of leukemia-associated immunophenotypes (FCM-MRD) is faster and biologically more informative. FCM-MRD performed in 18 laboratories across seven countries was used for risk stratification of 1487 patients with BCP-ALL enrolled in the NOPHO ALL2008 protocol. When no informative FCM-marker was available, risk stratification was based on real-time quantitative PCR. An informative FCM-marker was found in 96.2% and only two patients (0.14%) had non-informative FCM and non-informative PCR-markers. The overall 5-year event-free survival was 86.1% with a cumulative incidence of relapse (CIR5y) of 9.5%. FCM-MRD levels on days 15 (HzR 4.0, p < 0.0001), 29 (HzR 2.7, p < 0.0001), and 79 (HzR 3.5, p < 0.0001) associated with hazard of relapse adjusted for age, cytogenetics, and WBC. The early (day 15) response associated with CIR5y adjusted for day 29 FCM-MRD, with higher levels in adults (median 2.4 x 10(-2) versus 5.2 x 10(-3), p < 0.0001). Undetectable FCM- and/or PCR-MRD on day 29 identified patients with a very good outcome (CIR5y = 3.2%). For patients who did not undergo transplantation, day 79 FCM-MRD > 10(-4) associated with a CIR5y = 22.1%. In conclusion, FCM-MRD performed in a multicenter setting is a clinically useful method for MRD-based treatment stratification in BCP-ALL.

Published
2020
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219. p53 is associated with high-risk and pinpoints TP53 missense mutations in mantle cell lymphoma

Author

Rodrigues, Joana M., Hassan, May, Freiburghaus, Catja, Eskelund, Christian W., Geisler, Christian, Räty, Riikka, Kolstad, Arne, Sundström, Christer, Glimelius, Ingrid, Grønbæk, Kirsten, Kwiecinska, Anna, Porwit, Anna, Jerkeman, Mats, Ek, Sara, Rodrigues, Joana M., Hassan, May, Freiburghaus, Catja, Eskelund, Christian W., Geisler, Christian, Räty, Riikka, Kolstad, Arne, Sundström, Christer, Glimelius, Ingrid, Grønbæk, Kirsten, Kwiecinska, Anna, Porwit, Anna, Jerkeman, Mats, and Ek, Sara

Abstract

Survival for patients diagnosed with mantle cell lymphoma (MCL) has improved drastically in recent years. However, patients carrying mutations in tumour protein p53 (TP53) do not benefit from modern chemotherapy-based treatments and have poor prognosis. Thus, there is a clinical need to identify missense mutations through routine analysis to enable patient stratification. Sequencing is not widely implemented in clinical practice for MCL, and immunohistochemistry (IHC) is a feasible alternative to identify high-risk patients. The aim of the present study was to investigate the accuracy of p53 as a tool to identify patients with TP53 missense mutations and the prognostic impact of overexpression and mutations in a Swedish population-based cohort. In total, 317 cases were investigated using IHC and 255 cases were sequenced, enabling analysis of p53 and TP53 status among 137 cases divided over the two-cohort investigated. The accuracy of predicting missense mutations from protein expression was 82%, with sensitivity at 82% and specificity at 100% in paired samples. We further show the impact of p53 expression and TP53 mutations on survival (hazard ratio of 3·1 in univariate analysis for both), and the association to risk factors, such as high MCL International Prognostic Index, blastoid morphology and proliferation, in a population-based setting.

Published
2020

220. <scp>HAX</scp> ‐1 overexpression in multiple myeloma is associated with poor survival

Author

Anna Porwit, Bengt Fadeel, Xiaoli Feng, Eva Rossmann, Manuel Patarroyo, Anders Österborg, Taichi Ishikawa, Anna Kwiecinska, Matteo Bottai, and Chengyun Zheng

Subjects
medicine.medical_specialty, Hematology, business.industry, Gene Expression, Kaplan-Meier Estimate, Biology, Prognosis, medicine.disease, Text mining, Apoptosis, Internal medicine, Biomarkers, Tumor, medicine, Cancer research, Humans, Multiple Myeloma, business, Multiple myeloma, Adaptor Proteins, Signal Transducing
Published
2018

222. Clinical effect of increasing doses of lenalidomide in high-risk myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities

Author

Lars Möllgård, Leonie Saft, Marianne Bach Treppendahl, Ingunn Dybedal, Jan Maxwell Nørgaard, Jan Astermark, Elisabeth Ejerblad, Hege Garelius, Inge Høgh Dufva, Monika Jansson, Martin Jädersten, Lars Kjeldsen, Olle Linder, Lars Nilsson, Hanne Vestergaard, Anna Porwit, Kirsten Grønbæk, and Eva Hellström Lindberg

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Background Patients with chromosome 5 abnormalities and high-risk myelodysplastic syndromes or acute myeloid leukemia have a poor outcome. We hypothesized that increasing doses of lenalidomide may benefit this group of patients by inhibiting the tumor clone, as assessed by fluorescence in situ hybridization for del(5q31).Design and Methods Twenty-eight patients at diagnosis or with relapsed disease and not eligible for standard therapy (16 with acute myeloid leukemia, 12 with intermediate-risk 2 or high-risk myelodysplastic syndrome) were enrolled in this prospective phase II multicenter trial and treated with lenalidomide up to 30 mg daily for 16 weeks. Three patients had isolated del(5q), six had del(5q) plus one additional aberration, 14 had del(5q) and a complex karyotype, four had monosomy 5, and one had del(5q) identified by fluorescence in situ hybridization only.Results Major and minor cytogenetic responses, assessed by fluorescence in situ hybridization, were achieved in 5/26 (19%) and 2/26 (8%) patients, respectively, who received one or more dose of lenalidomide, while two patients achieved only a bone marrow response. Nine of all 26 patients (35%) and nine of the ten who completed the 16 weeks of trial responded to treatment. Using the International Working Group criteria for acute myeloid leukemia and myelodysplastic syndrome the overall response rate in treated patients with acute myeloid leukemia was 20% (3/15), while that for patients with myelodysplastic syndrome was 36% (4/11). Seven patients stopped therapy due to progressive disease and nine because of complications, most of which were disease-related. Response rates were similar in patients with isolated del(5q) and in those with additional aberrations. Interestingly, patients with TP53 mutations responded less well than those without mutations (2/13 versus 5/9, respectively; P=0.047). No responses were observed among 11 cases with deleterious TP53 mutations.Conclusions Our data support a role for higher doses of lenalidomide in poor prognosis patients with myelodysplastic syndrome and acute myeloid leukemia with deletion 5q. (Clinicaltrials.gov identifier NCT00761449).

Published
2011
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227. Value of flow cytometry for MRD-based relapse prediction in B-cell precursor ALL in a multicenter setting

Author

Modvig, S., primary, Hallböök, H., additional, Madsen, H. O., additional, Siitonen, S., additional, Rosthøj, S., additional, Tierens, A., additional, Juvonen, V., additional, Osnes, L. T. N., additional, Vålerhaugen, H., additional, Hultdin, M., additional, Matuzeviciene, R., additional, Stoskus, M., additional, Marincevic, M., additional, Lilleorg, A., additional, Ehinger, M., additional, Norén-Nystrøm, U., additional, Toft, N., additional, Taskinen, M., additional, Jónsson, O. G., additional, Pruunsild, K., additional, Vaitkeviciene, G., additional, Vettenranta, K., additional, Lund, B., additional, Abrahamsson, J., additional, Porwit, A., additional, Schmiegelow, K., additional, and Marquart, H. V., additional

Published
2020
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230. Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression

Author

Martin Jädersten, Leonie Saft, Andrea Pellagatti, Gudrun Göhring, James S. Wainscoat, Jacqueline Boultwood, Anna Porwit, Brigitte Schlegelberger, and Eva Hellström-Lindberg

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Clonal heterogeneity has not been described in patients with myelodysplastic syndrome with isolated del(5q), for which lenalidomide has emerged as a highly potent treatment. However, transformation to acute myeloid leukemia is occasionally observed, particularly in patients without a cytogenetic response to lenalidomide. We performed molecular studies in a patient with classical 5q- syndrome with complete erythroid and partial cytogenetic response to lenalidomide, who evolved to high-risk myelodysplastic syndrome with complex karyotype. Immunohistochemistry of pre-treatment marrow biopsies revealed a small fraction of progenitors with overexpression of p53 and sequencing confirmed a TP53 mutation. TP53 mutated subclones have not previously been described in myelodysplastic syndrome with isolated del(5q) and indicates a previously unknown heterogeneity of this disease. The aberrant subclone remained stable during the treatment with lenalidomide and expanded at transformation, suggesting that this pre-existing cell population had molecular features which made it insensitive to lenalidomide and prone to disease progression.

Published
2009
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231. Standardization of flow cytometry in myelodysplastic syndromes: report from the first European LeukemiaNet working conference on flow cytometry in myelodysplastic syndromes

Author

Arjan A. van de Loosdrecht, Canan Alhan, Marie Christine Béné, Matteo G. Della Porta, Angelika M. Dräger, Jean Feuillard, Patricia Font, Ulrich Germing, Detlef Haase, Christa H. Homburg, Robin Ireland, Joop H. Jansen, Wolfgang Kern, Luca Malcovati, Jeroen G. te Marvelde, Ghulam J. Mufti, Kiyoyuki Ogata, Alberto Orfao, Gert J. Ossenkoppele, Anna Porwit, Frank W. Preijers, Stephen J. Richards, Gerrit Jan Schuurhuis, Dolores Subirá, Peter Valent, Vincent H.J. van der Velden, Paresh Vyas, August H. Westra, Theo M. de Witte, Denise A. Wells, Michael R. Loken, and Theresia M. Westers

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

The myelodysplastic syndromes are a group of clonal hematopoietic stem cell diseases characterized by cytopenia(s), dysplasia in one or more cell lineages and increased risk of evolution to acute myeloid leukemia (AML). Recent advances in immunophenotyping of hematopoietic progenitor and maturing cells in dysplastic bone marrow point to a useful role for multiparameter flow cytometry (FCM) in the diagnosis and prognostication of myelodysplastic syndromes. In March 2008, representatives from 18 European institutes participated in a European LeukemiaNet (ELN) workshop held in Amsterdam as a first step towards standardization of FCM in myelodysplastic syndromes. Consensus was reached regarding standard methods for cell sampling, handling and processing. The group also defined minimal combinations of antibodies to analyze aberrant immunophenotypes and thus dysplasia. Examples are altered numbers of CD34+ precursors, aberrant expression of markers on myeloblasts, maturing myeloid cells, monocytes or erythroid precursors and the expression of lineage infidelity markers. When applied in practice, aberrant FCM patterns correlate well with morphology, the subclassification of myelodysplastic syndromes, and prognostic scoring systems. However, the group also concluded that despite strong evidence for an impact of FCM in myelodysplastic syndromes, further (prospective) validation of markers and immunophenotypic patterns are required against control patient groups as well as further standardization in multi-center studies. Standardization of FCM in myelodysplastic syndromes may thus contribute to improved diagnosis and prognostication of myelodysplastic syndromes in the future.

Published
2009
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232. Overexpression of CD123 correlates with the hyperdiploid genotype in acute lymphoblastic leukemia

Author

Miroslav Djokic, Elisabet Björklund, Elisabeth Blennow, Joanna Mazur, Stefan Söderhäll, and Anna Porwit

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

We evaluated CD123 expression in 95 pediatric and 24 adult ALL patients and compared the results with the CD123 expression in normal B-cell precursors. Early B-cell precursors were negative while intermediate precursors and mature B cells showed weak CD123 expression. Leukemic blasts in 31% of precursor-B ALL samples exhibited strong expression of CD123, 61% had moderate CD123 expression and 8% were negative; 81.5% of ALL with hyperdiploid karyotype (≥ 52 chromosomes) showed strong CD123 overexpression. In contrast, cases with ETV6/RUNX1 rearrangement had weak CD123 expression. Our study suggests that overexpression of CD123 is an aberrant phenotype present in a subset of precursor-B ALL with hyperdiploid genotype, and represents an additional marker of good prognosis in pediatric precursor-B ALL. Moreover, aberrant CD123 expression in ALL is a good marker for monitoring of minimal residual disease.

Published
2009
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240. Preface

Author

Porwit, Anna, primary, McCullough, Jeffrey, additional, and Erber, Wendy N., additional

Published
2011
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241. Contributors

Author

Abati, Andrea, primary, Arber, Daniel A., additional, Atayar, Çiğdem, additional, Bagg, Adam, additional, Bain, Barbara J., additional, Barry, Todd S., additional, Borowitz, Michael J., additional, Brousset, Pierre, additional, Brynes, Russell K., additional, Camacho, Francisca I., additional, Campo, Elias, additional, Chacón, Ignacio, additional, Chaganti, R.S.K., additional, Chan, Alexander C.L., additional, Chan, John K.C., additional, Chan, Wing C. (John), additional, Chang, Karen L., additional, Cheuk, Wah, additional, Connors, Joseph M., additional, Craig, Fiona E., additional, de la Cruz Mora, Miguel Ángel, additional, Delsol, Georges, additional, Djokic, Miroslav, additional, Duncan, Lyn McDivitt, additional, Elenitoba-Johnson, Kojo S.J., additional, Facchetti, Fabio, additional, Fend, Falko, additional, Ferry, Judith A., additional, Filie, Armando C., additional, Foucar, Kathryn, additional, García, Juan F., additional, Gascoyne, Randy D., additional, Gaulard, Philippe, additional, Greiner, Timothy C., additional, Hamilton, Katherine S., additional, Harris, Nancy Lee, additional, Hasserjian, Robert P., additional, Head, David R., additional, Heerema-McKenney, Amy, additional, Horny, Hans-Peter, additional, Houldsworth, Jane, additional, Hsi, Eric D., additional, Hutchison, Robert E., additional, Hyjek, Elizabeth, additional, Isaacson, Peter G., additional, Jaffe, Elaine S., additional, Jaffe, Ronald, additional, Jares, Pedro, additional, Jones, Dan, additional, Kadin, Marshall E., additional, Ko, Young Hyeh, additional, Kroft, Steven H., additional, Kumar, Shimareet, additional, Lamant-Rochaix, Laurence, additional, LeBoit, Philip E., additional, de Leval, Laurence, additional, Lim, Megan S., additional, McKenna, Robert W., additional, Medeiros, L. Jeffrey, additional, Mollejo, Manuela, additional, Montgomery, Karen Dyer, additional, Nanjangud, Gouri, additional, Natkunam, Yasodha, additional, Nelson, Beverly P., additional, Nguyen, Phuong L., additional, O’Malley, Dennis P., additional, Orazi, Attilio, additional, Ott, German, additional, Palanisamy, Nallasivam, additional, Peterson, LoAnn C., additional, Piris, Miguel A., additional, Pittaluga, Stefania, additional, Poppema, Sibrand, additional, Porwit, Anna, additional, Quintanilla-Martinez,, Priv.Doz.Dr. Leticia, additional, Racke, Frederick Karl, additional, Raffeld, Mark, additional, Ralfkiaer, Elisabeth, additional, Rezk, Sherif A., additional, Rosenthal, Nancy S., additional, Said, Jonathan, additional, Schnitzer, Bertram, additional, Siebert, Reiner, additional, Sotlar, Karl, additional, Stetler-Stevenson, Maryalice, additional, Sullivan, John L., additional, Swerdlow, Steven H., additional, Valent, Peter, additional, Vardiman, James W., additional, Viswanatha, David S., additional, Warnke, Roger A., additional, Weir, Edward G., additional, Weiss, Lawrence M., additional, Wilson, Carla S., additional, Woda, Bruce A., additional, Yuan, Constance M., additional, and Zhou, Fan, additional

Published
2011
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243. Contributors

Author

Anderson, Kenneth C., primary, Arber, Daniel A., additional, Arnold, Donald M., additional, Bain, Barbara J., additional, Béné, Marie Christine, additional, Bevan, David H., additional, Bock, Oliver, additional, Boles, Jeremiah C., additional, Bouma, Gerben, additional, Boyd, Scott D., additional, Buckley, Shannon M., additional, Büsche, Guntram, additional, Czader, Magdalena, additional, Daniels, Geoff, additional, Davies, Faith E., additional, Delaunay, Jean, additional, Erber, Wendy N., additional, Escolar, Gines, additional, Ferguson, David J.P., additional, Gordon-Smith, Edward C., additional, Green, Ralph, additional, Grove, Carolyn S., additional, Hall, Georgina W., additional, Heddle, Nancy M., additional, Horny, Hans-Peter, additional, Hurley, Carolyn Katovich, additional, Kelton, John G., additional, Key, Nigel S., additional, Kreipe, Hans H., additional, Kvasnicka, Hans M., additional, Layton, D. Mark, additional, MacCallum, Peter K., additional, May, Alison, additional, McCullough, Jeffrey, additional, Moonim, Mufaddal T., additional, Moore, Jane C., additional, Nazi, Ishac, additional, Newland, Adrian C., additional, Norström, Eva, additional, Orazi, Attilio, additional, Perry, David J., additional, Pippard, Martin J., additional, Porwit, Anna, additional, Posch, Phillip E., additional, Provan, Drew, additional, Renella, Raffaele, additional, Roper, David R., additional, Rosenquist, Richard, additional, Sørensen, Benny, additional, Thein, Swee Lay, additional, Thrasher, Adrian J., additional, van der Walt, Jon D., additional, Verfaillie, Catherine, additional, White, James G., additional, Wickramasinghe, Sunitha N., additional, Wilkins, Bridget S., additional, Wood, William G., additional, and Zini, Gina, additional

Published
2011
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244. Multicenter Prospective Evaluation of Diagnostic Potential of Flow Cytometric Aberrancies in Myelodysplastic Syndromes

Author

Matteo G. Della Porta, Dolores Subirá, Kate Burbury, Arjan A. van de Loosdrecht, Sergio Matarraz, Leonie Saft, Anna Porwit, Lisa Eidenschink Brodersen, Ulrika Johansson, Uta Oelschlaegel, Elisabeth Weiss, Marie C. Béné, Peter Bettelheim, Katherina Psarra, Frauke Bellos, Alan Stewart Dunlop, Sung-Chao Chu, Wolfgang Kern, Theresia M. Westers, Kiyoyuki Ogata, Frank Preijers, and Matthew J. Cullen

Subjects
Oncology, medicine.medical_specialty, business.industry, Myelodysplastic syndromes, Immunology, Cell Biology, Hematology, medicine.disease, Biochemistry, Prospective evaluation, hemic and lymphatic diseases, Internal medicine, Medicine, business
Abstract

Background: Myelodysplastic syndromes (MDS) are considered clonal diseases and are diagnosed according to WHO by cytomorphology and cytogenetics. The diagnostic potential of flow cytometric aberrancies has not yet been comprehensively evaluated. Aim: Multicenter prospective evaluation of diagnostic potential of flow cytometric aberrancies predefined according to European LeukemiaNet (ELN). Methods: 1682 patients undergoing diagnostics for suspected MDS according to WHO 2016 criteria were analyzed in parallel by flow cytometry according to ELN recommendations. Results: Median age was 72 years (18-97). MDS, MPN-RS-T or CMML were confirmed by cytomophology in 1029 (61%) cases, 653 (39%) were non-MDS. IPSS-R data was available in 857 (51%). An overall flow cytometric readout was available in 1679 (99.8%). 1001 (60%) were in agreement with MDS while 678 (40%) were not. Flow cytometric readout significantly correlated with cytomorphologic diagnosis (p Non-MDS cases had a fewer myeloid progenitor cells (MPC) (mean±SD, 0.8±0.9%) compared to low-risk MDS (1.7±2.3%, p3% was strongly associated with MDS/CMML (286/293, 98%, p Neutrophil aberrancies were found more frequently in neoplastic cases than in non-MDS cases (table 1). Again, frequencies of aberrations were higher for high-risk MDS as compared to low-risk MDS while this was not the case for CMML showing frequencies rather similar to low-risk MDS. Frequencies of aberrancies in monocytes revealed a similar figure as in neutrophils with higher rates in neoplastic cases but clearly significant numbers positive in non-MDS cases. Interestingly, frequencies were not higher in high-risk MDS as compared to low-risk MDS. As anticipated, frequencies were highest in CMML (table 1). Regarding erythroid cells only an aberrant percentage of them and aberrant CD71 expression were found in a reasonable number of cases. Importantly, rates of positivity were rather high in non-MDS cases which did not differ from CMML cases (table 1). In order to identify the diagnostic value of each individual aberrancy multivariate analyses were performed in the three subgroups, low-risk MDS, high-risk MDS and CMML, as well as in the total cohort. In low-risk MDS ten aberrancies were independently related to MDS (table 2). Five of these aberrancies were found in MPCs, two each in neutrophils and monocytes and one in erythroid cells. In high-risk MDS 11 aberrancies were independently related to MDS (table 2). Eight were found in MPCs, two in neutrophils, none in monocytes and one in erythroid cells. In CMML 12 aberrancies were independently related to CMML (table 2). Four were found in MPCs, neutrophils and monocytes, respectively, and none in erythroid cells. Considering all these three groups together and all aberrancies identified significantly related to MDS/CMML in at least one group in univariate analysis, multivariate analysis identified 12 aberrancies independently related to MDS/CMML (table 2). Six were found in MPCs, two in neutrophils, three in monocytes and one in erythroid cells. Taking into consideration only aberrancies independently associated with MDS/CMML, three such aberrancies resulted in an 80% agreement with the cytomorphologic diagnosis of MDS/CMML, i.e. 20% concordantly negative and 60% concordantly positive. Importantly, this applies without need of at least two cell compartments being affected as specified in the ELN recommendations. Conclusions: This multicenter prospective evaluation confirms the diagnostic potential of flow cytometric aberrancies. A core set of 17 markers identified as independently related to a diagnosis of MDS/CMML is suggested mandatory for flow cytometric evaluation of suspected MDS. An MPC count >3% should be considered indicative of MDS/CMML. Figure 1 Figure 1. Disclosures Kern: MLL Munich Leukemia Laboratory: Other: Part ownership. Eidenschink Brodersen: Hematologics, Inc.: Current Employment, Other: Equity Ownership. Van de Loosdrecht: Celgene: Consultancy, Research Funding; Amgen: Consultancy; Roche: Consultancy; Novartis: Consultancy; Alexion: Consultancy.

Published
2021

250. Dexamethasone-induced apoptosis in acute lymphoblastic leukemia involves differential regulation of Bcl-2 family members

Author

Edward Laane, Theocharis Panaretakis, Katja Pokrovskaja, Eva Buentke, Martin Corcoran, Stefan Söderhäll, Mats Heyman, Joanna Mazur, Boris Zhivotovsky, Anna Porwit, and Dan Grandér

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Background and Objectives The mechanism of glucocorticoid -induced apoptosis is not fully understood and early predictive assays based on apoptotic markers for clinical outcome in acute lymphoblastic leukemia (ALL) are scarce. The aim of this study was to characterize the involvement of Bcl-2 family members and caspase activation in dexamethasone(Dex)-induced apoptosis in ALL.Design and Methods Primary childhood ALL samples, the pre-B ALL cell line RS(4;11), and the T-ALL cell line CCRF-CEM were used. The involvement of Bcl-2 family members was evaluated by flow cytometry, immunocytochemistry, and western and northern blotting. Apoptosis was analyzed by annexin V and TMRE staining. Caspase activity was evaluated by a fluorometric assay.Results Dex induced significant down-regulation of the anti-apoptotic Bcl-2 family members Bcl-2 and Bcl-xL, differential activation of the pro-apoptotic Bak and Bax, loss of Δψm and cytochrome c release. Dex-induced apoptosis also involved early activation of caspases 2 and -3. Inhibition of caspase activity did not, however, protect against Dex-induced Bak/Bax activation, loss of Δψm or cell death. In 12 primary ALL samples Dex-induced apoptosis was associated with activation of Bax (p=0.045) and down-regulation of Bcl-2 (p=0.016) and/or Bcl-xL (p=0.004). Furthermore, ex vivo Dex-sensitivity was associated with an early treatment response to polychemotherapy (p=0.026).Interpretation and Conclusions The differential regulation of pro- and anti-apoptotic Bcl-2 family members appears to be a key event in the execution of Dex-induced apoptosis in ALL cell lines, and also indicates a role for these proteins in primary ALL cells.

Published
2007
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