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2,789 results on '"Pogue, Brian"'

202. Towards clinical translation of paired-agent imaging for FGS

Author

Samkoe, Kimberley S., primary, Wang, Cheng, additional, Sardar, Hira, additional, Gunn, Jason, additional, Hodge, Sassan, additional, Tafe, Laura, additional, Linos, Konstantinos, additional, Paydarfar, Joseph, additional, Henderson, Eric, additional, Pogue, Brian, additional, Chen, Eunice, additional, Elliott, Jonathan, additional, Tichauer, Kenneth, additional, and Paulsen, Keith, additional

Published
2022
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214. Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging

Author

Tichauer, Kenneth M., Samkoe, Kimberley S., Gunn, Jason R., Kanick, Stephen C., Hoopes, P.Jack, Barth, Richard J., Kaufman, Peter A., Hasan, Tayyaba, and Pogue, Brian W.

Subjects
Tumors -- Models -- Research -- Analysis, Lymph nodes -- Research, Biological sciences, Health
Abstract

Lymph node biopsy is employed in many cancer surgeries to identify metastatic disease and to determine cancer stage, yet morbidity and diagnostic delays associated with lymph node biopsy could be avoided if noninvasive imaging of nodal involvement were reliable. Molecular imaging has potential in this regard; however, variable delivery and nonspecific uptake of imaging tracers have made conventional approaches ineffective clinically. Here we present a method of correcting for nonspecific uptake with injection of a second untargeted tracer that allows for quantification of tumor burden in lymph nodes. We confirmed the approach in an athymic mouse model of metastatic human breast cancer by targeting epidermal growth factor receptor, a cell surface receptor overexpressed by many cancers. We observed a significant correlation between in vivo (dual-tracer) and ex vivo measures of tumor burden (r = 0.97, P < 0.01), with an ultimate sensitivity of approximately 200 cells (potentially more sensitive than conventional lymph node biopsy)., The presence or absence of cancer in tumor-draining lymph nodes is recognized as a key element for determining the stage of many cancers, and as a result, node localization and [...]

Published
2014
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232. Quantification of Oxygen Depletion During FLASH Irradiation In Vitro and In Vivo

Author

Cao, Xu, primary, Zhang, Rongxiao, additional, Esipova, Tatiana V., additional, Allu, Srinivasa Rao, additional, Ashraf, Ramish, additional, Rahman, Mahbubur, additional, Gunn, Jason R., additional, Bruza, Petr, additional, Gladstone, David J., additional, Williams, Benjamin B., additional, Swartz, Harold M., additional, Hoopes, P. Jack, additional, Vinogradov, Sergei A., additional, and Pogue, Brian W., additional

Published
2021
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245. Early identification of life-threatening soft-tissue infection using dynamic fluorescence imaging: first-in-kind clinical study of first-pass kinetics

Author

Gioux, Sylvain, Gibbs, Summer L., Pogue, Brian W., Streeter, Samuel S., Ray, Gabrielle S., Bateman, Logan M., Hebert, Kendra A., Bushee, Fallon E., Rodi, Scott W., Gitajn, I. Leah, Ahn, Jaimo, Singhal, Sunil, Martin, Niels D., Bernthal, Nicholas M., Lee, Christopher, Obremskey, William T., Shoenecker, Jonathan G., Elliott, Jonathan Thomas, and Henderson, Eric R.

Published
2023
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250. Broadband frequency-domain near-infrared spectral tomography using a mode-locked Ti:sapphire laser

Author

Wang, Jia, Jiang, Shudong, Paulsen, Keith D., and Pogue, Brian W.

Subjects
Broadband transmission -- Research, Tomography -- Methods, Lasers -- Properties, Lasers -- Usage, Infrared radiation -- Research, Spectrum analysis -- Methods, Diagnostic imaging -- Methods, Tissues -- Properties, Hemoglobin -- Properties, Oxygen -- Properties, Broadband Internet, Laser, Astronomy, Physics
Abstract

Frequency-domain near-infrared (NIR) diffuse spectral tomography with a mode-locked Ti:sapphire laser is presented, providing tunable multiwavelength quantitative spectroscopy with maximal power for thick tissue imaging. The system was developed to show that intrinsically high stability can be achieved with many wavelengths in the NIR range, using a mode-locked signal of 80 MHz with heterodyned lock-in detection. The effect of cumulative noise from multiple wavelengths of data on the reconstruction process was studied, and it was shown that inclusion of more wavelengths can reduce skew in the noise distribution. This normalization of the data variance then minimizes errors in estimation of chromophore concentrations. Simulations and tissue phantom experiments were used to quantify this improvement in image accuracy for recovery of tissue hemoglobin and oxygen saturation. OCIS codes: 170.3890, 170.6510, 300.6360.

Published
2009

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