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201. La aplicación del principio de subsidiariedad en la actividad económica del estado en el ordenamiento jurídico peruano

Author

Annie Fetta Pizzorno and Alberto Cairampoma Arroyo

Subjects
General Medicine
Abstract

El presente artículo aborda el principio de subsidiariedad en el marco de la economía social de mercado. Esto está relacionado en cómo se ha venido interpretando y aplicando el principio de subsidiariedad en nuestro ordenamiento jurídico. Así, a partir del cambio de los años 90 del rol del Estado de prestador a garante, y la incorporación del principio de subsidiariedad, se viene cuestionando sus alcances y límites. El Instituto Nacional de Defensa de la Competencia y de la Protección de la Propiedad Intelectual —en adelante, “Indecopi”— ha sido la entidad que viene resolviendo los casos que se presentan como posible vulneración al principio de subsidiariedad, y en ese contexto ha emitido un “precedente de observancia obligatoria”, el cual es sumamente importante analizar para poder dotar de contenido al artículo 60 de la Constitución.

Published
2021
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202. La vinculación entre la COVID19 y los Modelos de Gobernancia Corporativa

Author

Pizzorno, Vicente Constantino and Collacciani, Hugo

Subjects
Ciencias Económicas, COVID19, Gobernancia Corporativa, Empresas, Retornos Anormales, Acciones
Abstract

Se evaluó la respuesta de tres modelos de gobernancia corporativa a un cambio exógeno y disruptivo como la COVID19. Se realizó un estudio de eventos basado en retornos anormales de las acciones de veinticuatro empresas de seis países. Se emplearon dos técnicas: el modelo de mercado base CAPM y el modelo de Tres Factores de Fama & French. Se compararon rendimientos anormales pre y post hito obtenidos con ambos modelos. Esta comparación sugiere que el modelo Latino es el que presenta el menor impacto negativo. No se midió la precisión estadística de este resultado. En el análisis de regresión, no se corroboró que las variables correspondientes a los modelos de gobernancia tuvieran una vinculación estadísticamente significativa con los retornos anormales estudiados, aunque en la mayoría de los escenarios el resultado es estadísticamente significativo. Si bien existe cierta evidencia preliminar que sugiere una respuesta diferencial por parte de cada uno de los tres modelos de gobernancia analizados frente a la COVID19, para los niveles usuales de significancia se puede afirmar que los análisis de regresión realizados no permiten descartar la Hipótesis nula planteada. Por lo tanto, con los resultados obtenidos, no es posible corroborar la Hipótesis principal., Facultad de Ciencias Económicas

Published
2022

203. Preclinical evaluation of PHH-1V vaccine candidate against SARS-CoV-2 in non-human primates

Author

Antoni Prenafeta, Gregori Bech-Sàbat, Alexandra Moros, Antonio Barreiro, Alex Fernández, Manuel Cañete, Mercè Roca, Luis González-González, Carme Garriga, Joachim Confais, Marion Toussenot, Hugues Contamin, Andrés Pizzorno, Manuel Rosa-Calatrava, Edwards Pradenas, Silvia Marfil, Julià Blanco, Paula Cebollada Rica, Marta Sisteré-Oró, Andreas Meyerhans, Cristina Lorca, Joaquim Segalés, Teresa Prat, Ricard March, and Laura Ferrer

Abstract

SUMMARYSARS-CoV-2 emerged in December 2019 and quickly spread worldwide, continuously striking with an unpredictable evolution. Despite the success in vaccine production and mass vaccination programmes, the situation is not still completely controlled, and therefore accessible second-generation vaccines are required to mitigate the pandemic. We previously developed an adjuvanted vaccine candidate coded PHH-1V, based on a heterodimer fusion protein comprising the RBD domain of two SARS-CoV-2 variants. Here, we report data on the efficacy, safety, and immunogenicity of PHH-1V in cynomolgus macaques. PHH-1V prime-boost vaccination induces high levels of RBD-specific IgG binding and neutralising antibodies against several SARS-CoV-2 variants, as well as a balanced Th1/Th2 cellular immune response. Remarkably, PHH-1V vaccination prevents SARS-CoV-2 replication in the lower respiratory tract and significantly reduces viral load in the upper respiratory tract after an experimental infection. These results highlight the potential use of the PHH-1V vaccine in humans, currently undergoing Phase III clinical trials.

Published
2022
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205. In Vitro Combinations of Baloxavir Acid and Other Inhibitors against Seasonal Influenza A Viruses

Author

Liva Checkmahomed, Blandine Padey, Andrés Pizzorno, Olivier Terrier, Manuel Rosa-Calatrava, Yacine Abed, Mariana Baz, and Guy Boivin

Subjects
baloxavir, combination, influenza, A(H1N1) virus, A(H3N2) virus, polymerase inhibitors, Microbiology, QR1-502
Abstract

Two antiviral classes, the neuraminidase inhibitors (NAIs) and polymerase inhibitors (baloxavir marboxil and favipiravir) can be used to prevent and treat influenza infections during seasonal epidemics and pandemics. However, prolonged treatment may lead to the emergence of drug resistance. Therapeutic combinations constitute an alternative to prevent resistance and reduce antiviral doses. Therefore, we evaluated in vitro combinations of baloxavir acid (BXA) and other approved drugs against influenza A(H1N1)pdm09 and A(H3N2) subtypes. The determination of an effective concentration inhibiting virus cytopathic effects by 50% (EC50) for each drug and combination indexes (CIs) were based on cell viability. CompuSyn software was used to determine synergism, additivity or antagonism between drugs. Combinations of BXA and NAIs or favipiravir had synergistic effects on cell viability against the two influenza A subtypes. Those effects were confirmed using a physiological and predictive ex vivo reconstructed human airway epithelium model. On the other hand, the combination of BXA and ribavirin showed mixed results. Overall, BXA stands as a good candidate for combination with several existing drugs, notably oseltamivir and favipiravir, to improve in vitro antiviral activity. These results should be considered for further animal and clinical evaluations.

Published
2020
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206. Common Chemical Pollutants Causing a Lot of Ill Health

Author

Pizzorno, Joseph

Subjects
The Path Ahead
Abstract

Due to industrialization and inadequate controls on release of manufacturing chemicals into the environment and into the products being made, the entire population is constantly being exposed to a wide variety of chemical pollutants. The key question, of course, is their safety. The most acutely damaging ones have been progressively limited. However, virtually all safety research is on single toxins and very little of it looks at the impact of chronic exposure, especially chronic exposure to multiple chemicals simultaneously. This editorial discusses the clinical significance of 4 of the chemicals (acrolein, acrylamide, perchlorate, and phthalates) found most often in samples doctors send to labs for analysis. The research clearly demonstrates that these chemicals in a dose-dependent manner disrupt physiology, impair health, and increase risk for common diseases.

Published
2022

208. Primer registro de nematodos zoonóticos de transmisión alimentaria (Nematoda: Anisakidae) en músculo de Cynoscion guatucupa (pescadilla de calada) y Macrodon ancylodon (pescadilla de red) comercializado en Uruguay

Author

Crosi Martínez, Gonzalo, primary, García, Federico, additional, Viera, Gerardo, additional, Correa, Ivette, additional, Martínez, Valentina, additional, Pizzorno, Pablo, additional, Vidal, Gustavo, additional, Galli, Carina, additional, Trujillo, Lucía, additional, Díaz, Santiago, additional, Friss de Kereki, Cristina, additional, Dragonetti, José Pedro, additional, and Armúa Fernández, María Teresa, additional

Published
2022
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216. Tales of diversity: Genomic and morphological characteristics of forty-six Arthrobacter phages.

Author

Karen K Klyczek, J Alfred Bonilla, Deborah Jacobs-Sera, Tamarah L Adair, Patricia Afram, Katherine G Allen, Megan L Archambault, Rahat M Aziz, Filippa G Bagnasco, Sarah L Ball, Natalie A Barrett, Robert C Benjamin, Christopher J Blasi, Katherine Borst, Mary A Braun, Haley Broomell, Conner B Brown, Zachary S Brynell, Ashley B Bue, Sydney O Burke, William Casazza, Julia A Cautela, Kevin Chen, Nitish S Chimalakonda, Dylan Chudoff, Jade A Connor, Trevor S Cross, Kyra N Curtis, Jessica A Dahlke, Bethany M Deaton, Sarah J Degroote, Danielle M DeNigris, Katherine C DeRuff, Milan Dolan, David Dunbar, Marisa S Egan, Daniel R Evans, Abby K Fahnestock, Amal Farooq, Garrett Finn, Christopher R Fratus, Bobby L Gaffney, Rebecca A Garlena, Kelly E Garrigan, Bryan C Gibbon, Michael A Goedde, Carlos A Guerrero Bustamante, Melinda Harrison, Megan C Hartwell, Emily L Heckman, Jennifer Huang, Lee E Hughes, Kathryn M Hyduchak, Aswathi E Jacob, Machika Kaku, Allen W Karstens, Margaret A Kenna, Susheel Khetarpal, Rodney A King, Amanda L Kobokovich, Hannah Kolev, Sai A Konde, Elizabeth Kriese, Morgan E Lamey, Carter N Lantz, Jonathan S Lapin, Temiloluwa O Lawson, In Young Lee, Scott M Lee, Julia Y Lee-Soety, Emily M Lehmann, Shawn C London, A Javier Lopez, Kelly C Lynch, Catherine M Mageeney, Tetyana Martynyuk, Kevin J Mathew, Travis N Mavrich, Christopher M McDaniel, Hannah McDonald, C Joel McManus, Jessica E Medrano, Francis E Mele, Jennifer E Menninger, Sierra N Miller, Josephine E Minick, Courtney T Nabua, Caroline K Napoli, Martha Nkangabwa, Elizabeth A Oates, Cassandra T Ott, Sarah K Pellerino, William J Pinamont, Ross T Pirnie, Marie C Pizzorno, Emilee J Plautz, Welkin H Pope, Katelyn M Pruett, Gabbi Rickstrew, Patrick A Rimple, Claire A Rinehart, Kayla M Robinson, Victoria A Rose, Daniel A Russell, Amelia M Schick, Julia Schlossman, Victoria M Schneider, Chloe A Sells, Jeremy W Sieker, Morgan P Silva, Marissa M Silvi, Stephanie E Simon, Amanda K Staples, Isabelle L Steed, Emily L Stowe, Noah A Stueven, Porter T Swartz, Emma A Sweet, Abigail T Sweetman, Corrina Tender, Katrina Terry, Chrystal Thomas, Daniel S Thomas, Allison R Thompson, Lorianna Vanderveen, Rohan Varma, Hannah L Vaught, Quynh D Vo, Zachary T Vonberg, Vassie C Ware, Yasmene M Warrad, Kaitlyn E Wathen, Jonathan L Weinstein, Jacqueline F Wyper, Jakob R Yankauskas, Christine Zhang, and Graham F Hatfull

Subjects
Medicine, Science
Abstract

The vast bacteriophage population harbors an immense reservoir of genetic information. Almost 2000 phage genomes have been sequenced from phages infecting hosts in the phylum Actinobacteria, and analysis of these genomes reveals substantial diversity, pervasive mosaicism, and novel mechanisms for phage replication and lysogeny. Here, we describe the isolation and genomic characterization of 46 phages from environmental samples at various geographic locations in the U.S. infecting a single Arthrobacter sp. strain. These phages include representatives of all three virion morphologies, and Jasmine is the first sequenced podovirus of an actinobacterial host. The phages also span considerable sequence diversity, and can be grouped into 10 clusters according to their nucleotide diversity, and two singletons each with no close relatives. However, the clusters/singletons appear to be genomically well separated from each other, and relatively few genes are shared between clusters. Genome size varies from among the smallest of siphoviral phages (15,319 bp) to over 70 kbp, and G+C contents range from 45-68%, compared to 63.4% for the host genome. Although temperate phages are common among other actinobacterial hosts, these Arthrobacter phages are primarily lytic, and only the singleton Galaxy is likely temperate.

Published
2017
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217. Interactions Between Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Major Respiratory Viruses in Human Nasal Epithelium

Author

Andrés Pizzorno, Blandine Padey, Victoria Dulière, William Mouton, Justine Oliva, Emilie Laurent, Cedrine Milesi, Bruno Lina, Aurelien Traversier, Thomas Julien, Sophie Trouillet-Assant, Manuel Rosa-Calatrava, Olivier Terrier, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Terrier, Olivier

Subjects
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Infectious Diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Immunology and Allergy
Abstract

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), along with extensive nonpharmacological interventions, have profoundly altered the epidemiology of major respiratory viruses. Some studies have described virus-virus interactions, particularly manifested by viral interference mechanisms at different scales. However, our knowledge of the interactions between SARS-CoV-2 and other respiratory viruses remains incomplete. Here, we studied the interactions between SARS-CoV-2 and several respiratory viruses (influenza, respiratory syncytial virus, human metapneumovirus, and human rhinovirus) in a reconstituted human epithelial airway model, exploring different scenarios affecting the sequence and timing of coinfections. We show that the virus type and sequence of infections are key factors in virus-virus interactions, the primary infection having a determinant role in the immune response to the secondary infection.

Published
2022
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218. Strategies for Protecting Mitochondria From Metals and Chemicals

Author

Joseph, Pizzorno

Subjects
The Path Ahead
Abstract

Mitochondria are required for life, and dysfunction leads to chronic disease and shortened life expectancy. Unfortunately, suboptimal mitochondrial function is very common. While genetic mutations play a role, far more common is the damage from nutrient deficiencies and regular accidental and intentional exposure to mitotoxic metals and chemicals. Alcohol, antibiotics, metals, bisphenols, phthalates, pesticides and herbicides, and statins—the list is long—all impair mitochondrial function. Fortunately, toxins can be avoided and their elimination from the body can be enhanced. In addition, many natural health molecules help protect mitochondria and restore function.

Published
2022

219. Aspectos generales de la Ley número 17.250 de relaciones de consumo

Author

Teresita Mercader Pizzorno

Subjects
protección del consumidor, contrato de adhesión, clausula abusiva, incumplimiento contractual, responsabilidad contractual, prescripción, caducidad, Law in general. Comparative and uniform law. Jurisprudence, K1-7720, Social sciences (General), H1-99
Abstract

El 20 de setiembre de 1999 el Poder Ejecutivo de nuestro país promulgó una ley, la 17.189, por la que se establecían normas destinadas a regular las relaciones de consumo, la que fue publicada en el Diario Oficial del 30 de setiembre de 1999.Su último art., el 52, establecía que comenzaría a regir a los nueve meses contados desde su publicación. Por tanto, la fecha de entrada en vigencia fue ello. de julio del presente año.Sin embargo, un error acaecido en el proceso de elaboración determinó que, en forma prácticamente inmediata a su entrada en vigor, se procediera a elaborar un proyecto de ley para derogarla y sustituirla por otra, que fue promulgada el 11 de agosto de 2000 con el número 17.250 Y fue reglamentada por decreto 244/2000 del 23 de agosto del mismo año.El texto de la nueva leyes prácticamente igual al de la anterior, excepto, claro está, el artículo 33 que es el que había sido aprobado en el trámite de sanción en una y otra Cámara con distinto texto,También en la segunda ley se sustituyó el artículo 52 antes citado (...)

Published
2014

220. Solvent effect on the morphology of the bee: structure observed by atomic force microscopy on bitumen sample

Author

Bianca Pizzorno Backx, Renata Antoun Simão, Erico Rodrigues Dourado, and Leni Figueiredo Mathias Leite

Subjects
AFM, bitumen, asphaltene, nanostructures, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

The objective of this work was to characterize the asphaltic cement penetration grade 30/45 (CAP 30/45) based on the morphology of nanostructures called "bee" structure observed and its modification when the binder was diluted in heptanes or toluene. The morphology of CAP30/45, toluene and heptane films was studied by Atomic Force Microscopy (AFM) tapping mode and showed typical "bee" structure in asphaltic cement films, but this structure is not visible on the other films. While, toluene completely dissolved the bees, films attacked with heptane still presented some structures left.

Published
2014
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221. What do humpback whales Megaptera novaeangliae (Cetartiodactyla: Balaenopteridae) pairs do after tagging?

Author

Artur Andriolo, Alexandre N. Zerbini, Sergio Moreira, José L. Pizzorno, Daniel Danilewicz, Ygor G. Maia, Natália Mamede, Franciele R. de Castro, and Phillip Clapham

Subjects
Cetacean, large whale, satellite telemetry, social behavior, SSSM, Zoology, QL1-991
Abstract

The social structure of humpback whales in their tropical wintering grounds is very fluid. To date, no information has been published for cases in which two whales were both satellite-tagged while in association. Here, we report the movements of four humpback whale pairs tagged together off the coast of Brazil. Fieldwork and satellite tagging of humpback whales was conducted between 2003 and 2008 along the eastern coast of Brazil, between 20°S and 8°S. Movement was monitored while whales were still in their breeding ground. A switching state space model was applied to the filtered data of each humpback whale to standardize telemetry data and allow direct comparison of each individual track. GIS was used to plot model-predicted locations and to visually compare animal movements. The results confirm the short-lived nature of associations between breeding humpback whales, and shows that individuals differ widely in their movements.

Published
2014
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223. Smart materials and Green Synthesis: The perfect match for the future

Author

Bianca Pizzorno Backx

Subjects
Textile industry, Materials science, business.industry, Technological change, Significant difference, New materials, Biochemical engineering, business, Laboratory research, Smart material, Compensation (engineering)
Abstract

Materials science seeks the development of new materials with optimized characteristics. The union of various areas as chemistry, physics, nanotechnology, biology, and medicine catalyzes news materials. Smart materials react to external stimuli by modifying their chemical, mechanical, magnetic, optical, electrical, thermal properties. They have superior efficiency to the materials currently available and promise many advantages to their consumers. However, smart materials must be associated with sustainable technological progress. As a result of highly evolved technologies and intense laboratory research, their final characteristics must be connected with sustainable protocols. In addition to a significant difference associated with a wide application in various areas as textile industry, construction, medicine, drugs delivery, microorganisms’ detection, smart materials must not pollute from production to disposal, and more than that, they must seek compensation for the harmful effects of this evolution on nature. In this way, smart materials will be an excellent advantage for the future and the environment.

Published
2021
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224. Strain-Dependent Impact of G and SH Deletions Provide New Insights for Live-Attenuated HMPV Vaccine Development

Author

Julia Dubois, Andrés Pizzorno, Marie-Hélène Cavanagh, Blandine Padey, Claire Nicolas de Lamballerie, Olus Uyar, Marie-Christine Venable, Julie Carbonneau, Aurélien Traversier, Thomas Julien, Sophie Lavigne, Christian Couture, Bruno Lina, Marie-Ève Hamelin, Olivier Terrier, Manuel Rosa-Calatrava, and Guy Boivin

Subjects
human metapneumovirus (hmpv), live-attenuated vaccine (lav), g protein, sh protein, gene deletion, reverse genetics, Medicine
Abstract

Human metapneumovirus (HMPV) is a major pediatric respiratory pathogen with currently no specific treatment or licensed vaccine. Different strategies to prevent this infection have been evaluated, including live-attenuated vaccines (LAV) based on SH and/or G protein deletions. This approach showed promising outcomes but has not been evaluated further using different viral strains. In that regard, we previously showed that different HMPV strains harbor distinct in vitro fusogenic and in vivo pathogenic phenotypes, possibly influencing the selection of vaccine strains. In this study, we investigated the putative contribution of the low conserved SH or G accessory proteins in such strain-dependent phenotypes and generated recombinant wild type (WT) and SH- or G-deleted viruses derived from two different patient-derived HMPV strains, A1/C-85473 and B2/CAN98-75. The ΔSH and ΔG deletions led to different strain-specific phenotypes in both LLC-MK2 cell and reconstituted human airway epithelium models. More interestingly, the ΔG-85473 and especially ΔSH-C-85473 recombinant viruses conferred significant protection against HMPV challenge and induced immunogenicity against a heterologous strain. In conclusion, our results show that the viral genetic backbone should be considered in the design of live-attenuated HMPV vaccines, and that a SH-deleted virus based on the A1/C-85473 HMPV strain could be a promising LAV candidate as it is both attenuated and protective in mice while being efficiently produced in a cell-based system.

Published
2019
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225. Interactions Between Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Major Respiratory Viruses in Human Nasal Epithelium

Author

Pizzorno, Andrés, primary, Padey, Blandine, additional, Dulière, Victoria, additional, Mouton, William, additional, Oliva, Justine, additional, Laurent, Emilie, additional, Milesi, Cedrine, additional, Lina, Bruno, additional, Traversier, Aurelien, additional, Julien, Thomas, additional, Trouillet-Assant, Sophie, additional, Rosa-Calatrava, Manuel, additional, and Terrier, Olivier, additional

Published
2022
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227. Anthracycline-Free Neoadjuvant Treatment in Patients with HER2-Positive Breast Cancer: Real-Life Use of Pertuzumab, Trastuzumab and Taxanes Association with an Exploratory Analysis of PIK3CA Mutational Status

Author

Irelli, Azzurra, primary, Parisi, Alessandro, additional, D’Orazio, Carla, additional, Sidoni, Tina, additional, Rotondaro, Silvia, additional, Patruno, Leonardo, additional, Pavese, Francesco, additional, Bafile, Alberto, additional, Resta, Valter, additional, Pizzorno, Laura, additional, Ciuffetelli, Virginia, additional, Dalmas, Antonella, additional, Calvisi, Giuseppe, additional, Di Sibio, Alessandra, additional, Marzullo, Anna, additional, Zelli, Veronica, additional, Compagnoni, Chiara, additional, Tessitore, Alessandra, additional, Alesse, Edoardo, additional, Ficorella, Corrado, additional, Cortellini, Alessio, additional, and Cannita, Katia, additional

Published
2022
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229. Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium in vitro

Author

Jonsdottir, Hulda R., primary, Siegrist, Denise, additional, Julien, Thomas, additional, Padey, Blandine, additional, Bouveret, Mendy, additional, Terrier, Olivier, additional, Pizzorno, Andres, additional, Huang, Song, additional, Samby, Kirandeep, additional, Wells, Timothy N.C., additional, Boda, Bernadett, additional, Rosa-Calatrava, Manuel, additional, Engler, Olivier B., additional, and Constant, Samuel, additional

Published
2022
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230. Breakthrough SARS-CoV-2 infections after COVID-19 mRNA vaccination in MS patients on disease modifying therapies during the Delta and the Omicron waves in Italy

Author

Sormani, Maria Pia, primary, Schiavetti, Irene, additional, Inglese, Matilde, additional, Carmisciano, Luca, additional, Laroni, Alice, additional, Lapucci, Caterina, additional, Visconti, Valeria, additional, Serrati, Carlo, additional, Gandoglia, Ilaria, additional, Tassinari, Tiziana, additional, Perego, Germana, additional, Brichetto, Giampaolo, additional, Gazzola, Paola, additional, Mannironi, Antonio, additional, Stromillo, Maria Laura, additional, Cordioli, Cinzia, additional, Landi, Doriana, additional, Clerico, Marinella, additional, Signoriello, Elisabetta, additional, Cocco, Eleonora, additional, Frau, Jessica, additional, Ferrò, Maria Teresa, additional, Di Sapio, Alessia, additional, Pasquali, Livia, additional, Ulivelli, Monica, additional, Marinelli, Fabiana, additional, Pizzorno, Matteo, additional, Callari, Graziella, additional, Iodice, Rosa, additional, Liberatore, Giuseppe, additional, Caleri, Francesca, additional, Repice, Anna Maria, additional, Cordera, Susanna, additional, Battaglia, Mario Alberto, additional, Salvetti, Marco, additional, Franciotta, Diego, additional, Uccelli, Antonio, additional, Maglione, Alessandro, additional, Sapio, Alessia Di, additional, Signori, Alessio, additional, Iovino, Aniello, additional, Maria Repice, Anna, additional, Gabri Nicoletti, Carolina, additional, Mancinelli, Chiara Rosa, additional, Bezzini, Daiana, additional, Carmagnini, Daniele, additional, Brogi, Davide, additional, Nobile Orazio, Eduardo, additional, Nako, Enri, additional, Assandrir, Ester, additional, Baldi, Federica, additional, Ansaldi, Filippo, additional, Bovis, Francesca, additional, Siciliano, Gabriele, additional, Cola, Gaia, additional, Lus, Giacomo, additional, Icardi, Giancarlo, additional, Bellucci, Gianmarco, additional, Da Rin, Giorgio, additional, Alessandra Marfia, Girolama, additional, Vazzoler, Giulia, additional, Trivelli, Giuseppe, additional, Maietta, Ilaria, additional, Sticchi, Laura, additional, Lorefice, Lorena, additional, Ruggiero, Lucia, additional, Manzino, Marcello, additional, Monti Bragadin, Margherita, additional, Chiara Buscarinu, Maria, additional, Gagliardi, Maria, additional, Laura Stromillo, Maria, additional, Pia Sormani, Maria, additional, Rilla, Maria Teresa, additional, Alberto Battaglia, Mario, additional, Ponzano, Marta, additional, Fronza, Marzia, additional, Del Sette, Massimo, additional, Scialabba, Matteo, additional, Bedognetti, Michele, additional, De Rossi, Nicola, additional, De Stefano, Nicola, additional, Bigi, Rachele, additional, Dubbioso, Raffaele, additional, Reniè, Roberta, additional, Fabbri, Sabrina, additional, Rasia, Sarah, additional, Rolla, Simona, additional, Platzgummer, Stefan, additional, and Carlini, Valentina, additional

Published
2022
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231. Unconscious Processes in a Career Counselling Case: An Action-Theoretical Perspective

Author

Dyer, Brenda, Pizzorno, Maria Chiara, and Qu, Kejia

Abstract

Although clients and counselors can often account for their actions in counselling, sometimes the link between the action taken and the larger goal is not apparent. This article accounts for counterproductive, paradoxical actions within the counselling process by addressing unconscious processes as links between immediate actions and larger projects. A career counselling case is presented, the data of which were gathered and analysed through the action-project method. This method includes a video-supported recall procedure, called the self-confrontation interview, as a research and practice means of accessing unconscious aspects of the inter-subjective action of counselling. The complexity of career counselling is illustrated as multiple goals and projects, both conscious and unconscious, are manifest in a single session. Implications for practice include the primacy of the relationship project in career counselling as the relationship project not only contains but reflects other projects such as identity and vocational projects. (Contains 1 note.)

Published
2010
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233. Consideration for Flavonoid-Containing Dietary Supplements to Tackle Deficiency and Optimize Health

Author

Julia Solnier, Chuck Chang, and Joseph Pizzorno

Subjects
Inorganic Chemistry, Organic Chemistry, General Medicine, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy, Catalysis, Computer Science Applications
Abstract

Randomized clinical trials (RCT) and observational studies have highlighted the importance of flavonoid consumption for human health. Several studies have associated a high intake of dietary flavonoids with (a) enhanced metabolic and cardiovascular health, (b) enhanced cognitive and vascular endothelial functions, (c) an improved glycemic response in type 2 diabetes mellitus, and (d) a reduced risk of breast cancer in postmenopausal women. Since flavonoids belong to a broad and diverse family of polyphenolic plant molecules—with more than 6000 compounds interspersed in the human diet—researchers are still uncertain whether the intake of single, individual polyphenols or a large combination of them (i.e., synergistic action) can produce the greatest health benefits for humans. Furthermore, studies have reported a poor bioavailability of flavonoid compounds in humans, which presents a major challenge for determining their optimal dosage, recommended intake, and, consequently, their therapeutic value. Especially because of their scarce bioavailability from foods—along with the overall declining food quality and nutrient density in foods—the role of flavonoid supplementation may become increasingly important for human health. Although research shows that dietary supplements can be a highly useful tool to complement diets that lack sufficient amounts of important nutrients, some caution is warranted regarding possible interactions with prescription and non-prescription drugs, especially when taken concurrently. Herein, we discuss the current scientific basis for using flavonoid supplementation to improve health as well as the limitations related to high intakes of dietary flavonoids.

Published
2023
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234. Polycyclic aromatic hydrocarbons and risk of rheumatoid arthritis: a cross-sectional analysis of the National Health and Nutrition Examination Survey, 2007–2016

Author

Michelle Beidelschies, Rocio Lopez, Joseph Pizzorno, Phuc Le, Michael B Rothberg, M E Husni, and Christopher D'Adamo

Subjects
General Medicine
Abstract

ObjectiveWhile there are several well-established environmental risk factors for rheumatoid arthritis (RA), a paucity of evidence exists linking environmental toxicants with RA prevalence. We aimed to examine the associations between various environmental toxicants and RA among adults in the U.S. general population while adjusting for non-heritable risk factors.DesignCross-sectional study.SettingNational Health and Nutrition Examination Survey conducted from 2007 to 2016.ParticipantsThe study included 21 987 adult participants (no RA: 20 569; RA: 1418). Participants were excluded (n=7214) if they did not answer questions related to self-reporting of RA, had another or unknown type of arthritis, or did not have interview or biospecimen data.Primary and secondary outcome measuresAssociation between individual toxicants and body burden scores for polycyclic aromatic hydrocarbons (PAH), phthalates and plasticisers (PHTHTEs) metabolites or volatile organic compounds (VOCs) and participant self-reported RA based on multivariable logistic regression models while adjusting for age, sex, urine creatinine, body mass index, smoking, race, education, family poverty income ratio, any vigorous or moderate activity and dietary fibre.ResultsWhile increased prevalence of RA was observed in participants with the highest quartile of various individual PAHs, only 1-hydroxynaphthalene (OR: 1.8 (1.1 to 3.1); p=0.020) remained associated in a fully adjusted model. PAH body burden was found to be associated with RA (Q4 vs Q1, OR: 2.2 (1.09 to 4.2); p=0.028) in a fully adjusted model. Interestingly, after accounting for PAH body burden, smoking was not associated with RA (OR: 1.4 (0.89 to 2.3); p=0.13). A mediation analysis demonstrated that PAH body burden accounted for 90% of the total effect of smoking on RA. PHTHTE and VOC metabolites were not associated with RA in fully adjusted models.Conclusions and relevancePAHs are associated with RA prevalence, mediate the majority of the effects of smoking on RA, and are associated with RA independent of smoking status.

Published
2023
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237. CD9, a tetraspanin target for cancer therapy?

Author

Jana Karbanová, Denis Corbeil, Giuseppe Pizzorno, Marco Lorico-Rappa, and Aurelio Lorico

Subjects
0301 basic medicine, medicine.medical_treatment, medicine.disease_cause, Bioinformatics, Exosome, Tetraspanin 29, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Tetraspanin, Neoplasms, Animals, Humans, Medicine, business.industry, Cancer, Extracellular vesicle, Immunotherapy, medicine.disease, Biomarker (cell), 030104 developmental biology, 030220 oncology & carcinogenesis, embryonic structures, Minireview, business, Carcinogenesis, Function (biology)
Abstract

In the present minireview, we intend to provide a brief history of the field of CD9 involvement in oncogenesis and in the metastatic process of cancer, considering its potential value as a tumor-associated antigenic target. Over the years, CD9 has been identified as a favorable prognostic marker or predictor of metastatic potential depending on the cancer type. To understand its implications in cancer beside its use as an antigenic biomarker, it is essential to know its physiological functions, including its molecular partners in a given cell system. Moreover, the discovery that CD9 is one of the most specific and broadly expressed markers of extracellular membrane vesicles, nanometer-sized entities that are released into extracellular space and various physiological body fluids and play a role in intercellular communication under physiological and pathological conditions, notably the establishment of cancer metastases, has added a new dimension to our knowledge of CD9 function in cancer. Here, we will discuss these issues as well as the possible cancer therapeutic implications of CD9, their limitations, and pitfalls.

Published
2021
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239. Adaptations of the elderly for the access to healthcare during the COVID-19 lockdown: a qualitative study

Author

Mariano Granero, Juan Víctor Ariel Franco, Candela Loza, German Baez, Rodrigo Valverdi, Pedro Pisula, Julieta Salas Apaza, and Ximena Salomé Pizzorno Santoro

Subjects
Health (social science), Sociology and Political Science, Health Policy
Abstract

IntroducciónEl 19 marzo de 2020 se decretó el aislamiento social preventivo y obligatorio en la Argentina como respuesta a la pandemia por el virus SARS-CoV-2 y la enfermedad que causa (COVID-19). ObjetivosExplorar las experiencias de los adultos mayores con relación al cuidado de su salud durante la cuarentena por Covid-19, los problemas en la accesibilidad al sistema de salud y las adaptaciones emergentes. Métodos Investigación con abordaje cualitativo. Los participantes fueron adultos mayores de 60 años. Mediante un muestreo en bola de nieve, el equipo investigador contactó telefónicamente a los participantes donde se realizó una entrevista semiestructurada. Se trianguló el análisis de los hallazgos entre los investigadores con distinta formación académica. Se realizaron mapas conceptuales a través de los cuales se eligieron los ejes temáticos a abordar.Resultados Se entrevistaron a 39 participantes Ciudad autónoma de Buenos aires en el período entre los meses de abril y julio del año 2020. Los principales temas emergentes fueron: 1) acceso a consultas programadas habituales, 2) acceso a la medicación crónica, 3) consultas agudas y emergentes y 4) el rol de las tecnologías de información y comunicación. La accesibilidad al sistema de salud se vio comprometida por la disminución de oferta de consultas presenciales, afectando los controles de salud, el diagnóstico y tratamiento de enfermedades. Sin embargo, los participantes intentaron mantener al día sus inmunizaciones. Las tecnologías de la información y comunicación permitieron la emisión de recetas virtuales y las teleconsultas. Si bien esto representó una solución para muchos adultos mayores, también generó un problema para otros que no tenían acceso o no sabían utilizarlas.ConclusiónLa pandemia afectó la accesibilidad al sistema de salud, a expensas principalmente de un menor acceso a consultas de modalidad presencial. Las necesidades emergentes obligaron la aparición de nuevas estrategias de atención, como ser las tecnologías de información y comunicación. Esto, si bien significó una solución, también generó nuevos excluidos debido a la brecha tecnológica preexistente.

Published
2022

240. Relaciones y tensiones en el campo de la educación física: IV Congreso Patagónico y I Congreso Nacional de Educación Física y Formación Docente. Relaciones y tensiones en el campo de la educación física

Author

Fernández, Marisa, Copolechio Morand, Marina, Pizzorno, Federico, Vargas, Nancy, López, Eduardo, Rolandelli, Delfina, Marelli, Martín, Sacarelo, Cristina, Durán Céspedes, Walter, Wheeler, Andrew, Diez, Sofía, Beddur, Sergio, Martínez, Carolina, Marchiselli, Javier, Galosi, Carlos, Ruiz, Edgardo, Martins, Fabián, Cárdenas, Juan, Carballo, Lourdes, López Medero, Norma, Sgrinzi, Cinthia, Bondel, Gabriel, Alder, Inés, Palacio, Mónica, Lehr, Axel, Rovere, Adriana, Lanza, Matías, Rivero, Ivana, Gilleta, Viviana, Brizuela, Anabella, Auvieux, Ernesto, Galván, Julieta, Avaca, Carina, Mangone, Analía, Centaure, Adrián, Corbera, Adolfo, Alvarez Durán, Lucas, Renzi, Gladys, Rodríguez, Alejandra, Oroño, Marcela, Corbo, José, Díaz, María J, Bisceglia, Adriana, Delocca, Natalia, Vidal, María F, Mansi, Daniela, Gómez Smyth, Leonardo, Jenks, Zulma, Peña, Francisco, Villafañe, Gerardo, Rozas Sía, Facundo, Lescano, Eliana, Cristófano, Moira, Almada, Cecilia, Griffa, Marcos, Coppola, Gustavo, Corzo, María C, Rodríguez, Soledad, Sorín, Ernesto, Bío, Claudio, Mendoza, Leroy, Matozza, Gabriela, Bengohechea, María F, Oviedo, Sandro, Saraví, Jorge, Mársico, Leonardo, Cayún Pichunlef, Gustavo, Rodriguez, Andrea, Reising, María L, Sepúlveda, Lucas, Bustos, Paula, Layana, Julieta, Di Domizio, Débora, Torelli, Georgina, Alarcón, María C, and Cuenca, Valeria

Subjects
Pedagogía de la educación física, Ciencias Sociales, Ciencias de la Educación, Prácticas inclusivas en la educación física, Educación física, Formación docente
Abstract

El libro nos presenta las reflexiones y debates acerca de algunas relaciones y tensiones en el campo de la Educación Física, así como también la promoción de intercambios y la socialización de propuestas pedagógicas, de proyectos de extensión, de investigación y de gestión, suscitadas en el marco del IV Congreso Patagónico y I Congreso Nacional de Educación Física y Formación Docente y a partir de 2 grandes ejes: 1 La Educación Física y enseñanza en diferentes contextos; y 2 La Educación Física y prácticas inclusivas. Fil: Rolandelli, Delfina. Universidad Nacional de la Plata; Argentina. Fil: Marelli, Martín. Universidad Nacional de la Plata; Argentina. Fil: Beddur, Sergio. Universidad Nacional de Tucumán; Argentina. Fil: Diez, Sofía. Universidad Nacional de Tucumán; Argentina. Fil: Wheeler, Andrew. Universidad Nacional de Tucumán; Argentina. Fil: Durán Céspedes, Walter. Universidad de Chile; Chile. Fil: Martínez, Carolina. Instituto Superior de Formación Docente Nº 84; Argentina. Fil: Marchiselli, Javier. Instituto Superior de Formación Docente Nº 84; Argentina. Fil: Ruiz, Santiago. Universidad Nacional de Tucumán; Argentina. Fil: Lehr, Axel. Universidad Nacional de Quilmes; Argentina. Fil: Rovere, Adriana. Universidad Nacional de Río Negro; Argentina. Fil: Lanza, Matías. Universidad Nacional de la Plata; Argentina. Fil: Rivero, Ivana. Universidad Nacional de Río Cuarto; Argentina. Fil: Gilleta, Viviana. Universidad Nacional de Río Cuarto; Argentina. Fil: Galván, Julieta. Universidad Nacional de Tucumán; Argentina. Fil: Auvieux, Ernesto. Universidad Nacional de Tucumán; Argentina. Fil: Brizuela, Anabella. Universidad Nacional de Tucumán; Argentina. Fil: Avaca, Carina. Universidad Nacional de Tucumán; Argentina. Fil: Mangone, Analía. Universidad Nacional de Tucumán; Argentina. Fil: Centaure, Adrian. Instituto Superior de Formación Docente Nº 2; Argentina. Fil: Corbera, Adolfo. Instituto Superior de Formación Docente Nº 2; Argentina. Fil: Álvarez Durán, Lucas. Instituto Superior de Formación Docente Nº 84; Argentina. Fil: Renzi, Gladys. Universidad Nacional de Avellaneda; Argentina. Fil: Rodríguez, Alejandra. Universidad de la República; Uruguay. Fil: Oroño, Marcela. Universidad de la República; Uruguay. Fil: Corbo, José L. Universidad de la República; Uruguay. Fil: Díaz, María J. Instituto Superior de Formación Docente Nº 84; Argentina. Fil: Alderete, Carolina. Instituto Superior de Bella Vista; Argentina. Fil: Bisceglia, Adriana. Universidad Nacional de la Plata; Argentina. Fil: Delocca, Natalia. Universidad Nacional de la Plata; Argentina. Fil: Vidal, María F. Universidad Nacional de la Plata; Argentina. Fil: Gómez Smyth, Leonardo. Universidad de Flores; Argentina. Fil: Mansi, Daniela. Universidad de Flores; Argentina. Fil: Peña, Francisco. Ministerio Educación de Tucumán; Argentina. Fil: Jenks, Zulma. Universidad Nacional de Tucumán; Argentina. Fil: Villafañe, Gerardo. Ministerio Educación de Tucumán; Argentina. Fil: Rozas Sia, Facundo. Universidad Nacional de La Plata; Argentina. Fil: Lescano, Eliana. Universidad Nacional de La Plata; Argentina. Fil: Cristófano, Moira. Universidad Nacional de La Plata; Argentina. Fil: Almada, Cecilia. Universidad Nacional de Avellaneda; Argentina. Fil: Griffa, Marcos. Universidad Provincial de Córdoba; Argentina. Fil: Almada, Cecilia. Universidad Nacional de Avellaneda; Argentina. Fil: Coppola, Gustavo. Universidad Provincial de Córdoba; Argentina. Fil: Corzo, María C. Universidad Provincial de Córdoba; Argentina. Fil: Rodríguez, María S. Universidad Provincial de Córdoba; Argentina. Fil: Sorín, Ernesto. Universidad Provincial de Córdoba; Argentina. Fil: Begohechea, María F. Universidad Nacional de Avellaneda; Argentina. Fil: Oviedo, Sandro. Universidad Nacional de Río Cuarto; Argentina. Fil: Saraví, Jorge. Universidad Nacional de la Plata; Argentina. Fil: Rodriguez, Andrea. Universidad Nacional de la Plata; Argentina. Fil: Layana, Julieta. Centro Educativo y Cultural Cre-Arte; Argentina. Fil: Bustos, Paula. Centro Educativo y Cultural Cre-Arte; Argentina. Fil: Di Domizio, Débora. Universidad Nacional de la Plata; Argentina. Fil: Torelli, Georgina. Universidad Nacional de la Plata; Argentina. Fil: Alarcón, María C. Universidad Nacional de la Plata; Argentina. Fil: Cuenca, Valeria. Universidad Nacional de la Plata; Argentina. Fil: Pizzorno, Federico. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Sacarelo, Cristina. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Galosi, Carlos. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Martins, Fabián. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Cárdenas, Juan R. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Carballo, Lourdes. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: López Medero, Norma. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Sgrinzi, Cinthia M. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: López, Eduardo. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Fernández, Marisa. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Bondel, Gabriel. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Alder, Inés. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Palacio, Mónica. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Copolechio Morand, Marina. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Bio, Claudio. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Mendoza, Leroy. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Matozza, Gabriela. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Mársico, Leonardo. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Cayún Pichunlef, Gustavo. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Reising, María L. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Sepúlveda, Lucas. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina.

Published
2022

241. Environmental Toxins Are a Major Cause of Bone Loss

Author

Joseph, Pizzorno and Lara, Pizzorno

Subjects
The Path Ahead
Abstract

The environmental metals cadmium, lead, and mercury, and chemicals such as pesticides, phthalates, and bisphenols, disrupt bone metabolism in many ways. Body levels of these toxins directly correlate, in a dose-dependent manner, with risk of fracture and osteoporosis. This editorial provides a brief summary of key research showing mechanisms of damage, sources, and key strategies to decrease body load.

Published
2021

242. Commonly Prescribed and Over-the-Counter Drugs as Secondary Causes of Osteoporosis-Part Two

Author

Joseph, Pizzorno and Lara, Pizzorno

Subjects
The Path Ahead
Abstract

In this second of a 2-part editorial, we continue our discussion of the importance of being aware that some clinically important prescription drugs can impair bone metabolism. While obviously most critical for women (and men) with osteopenia or osteoporosis, the guidance here is directly relevant to all patients as many are already experiencing decreased bone regeneration even if not severe enough for a formal diagnosis. Part One covered aromatase inhibitors, gonadotropin-releasing hormone agonists, anticonvulsants, benzodiazepines, antidepressants, insulin sensitizers, and NSAIDs and acetaminophen. Part Two covers opioids, glucocorticoids, calcineurin inhibitors, gastric acid blockers, diuretics, anti-coagulants, thyroid hormone medications, and contraceptives.

Published
2021

243. Commonly Prescribed and Over-the-Counter Drugs as Secondary Causes of Osteoporosis-Part One

Author

Joseph, Pizzorno and Lara, Pizzorno

Subjects
The Path Ahead
Abstract

Prescription and over-the-counter drugs have been effectively used to manage many diseases and to provide symptom relief. Unfortunately, their use may also result in adverse drug reactions and unintended consequences. Proper use of these powerful agents requires understanding both their desired effects and their potential downsides. Fully understanding the unintended consequences can be challenging. Virtually all safety studies are carried out for far shorter periods of time than the actual use of these agents in the real world. Some may take years of use before their sequelae are recognized. This is especially a problem where bone health is concerned since the damage caused by years of minor disruption in function does not show up until compounded by other factors, such as andropause and menopause. This 2-part editorial covers the primary classes of drugs that require bone health monitoring and that may require alternative prescriptions or mitigation strategies. Part One covers aromatase inhibitors, gonadotropin-releasing hormone agonists, anticonvulsants, benzodiazepines, antidepressants, insulin sensitizers, and NSAIDs and acetaminophen. Part Two covers opioids, glucocorticoids, calcineurin inhibitors, H2 blockers, diuretics, anticoagulants, thyroid medications, and contraceptives.

Published
2021

244. Retrato das bibliotecas da rede de ensino municipal de Santa Catarina

Author

Ohira, Lourdes Blatt, Neto, Orestes Trevisol, Sena, Priscila Machado Borges, Pizzorno, Ana Cláudia Philippi, Barreto, Mônica Valério, Ohira, Lourdes Blatt, Neto, Orestes Trevisol, Sena, Priscila Machado Borges, Pizzorno, Ana Cláudia Philippi, and Barreto, Mônica Valério

Abstract

São apresentados os resultados da pesquisa Retrato das Bibliotecas da Rede de Ensino Municipal de Santa Catarina. Realizou-se uma pesquisa aplicada, exploratória e descritiva, com análises quantitativas e qualitativas. O universo da pesquisa constituiu-se de 416 escolas que possuem a partir de 400 estudantes matriculados. Utilizou-se questionário com questões fechadas e possibilidade de comentários abertos, disseminado pelo serviço online Formulários Google, enviado aos e-mails gerais das escolas e específicos das direções. Obteve-se 101 respostas, oriundas de 34 munícipios de diferentes regiões do Estado. Identificou-se 79bibliotecas em funcionamento, 9desativadas, e 13inexistentes. A maioria são gerenciadas por professores(as), sendo que apenas 4 munícipios contam com bibliotecários(as) em seus quadros profissionais, totalizando 18, com destaque para Florianópolis que possui uma rede de bibliotecas escolares estruturada, abrangendo 14 profissionais. A maioria das escolas possuem bibliotecas e atendem parcialmente os parâmetros básicos no tocante ao número de títulos, espaço físico e serviços prestados, estipulados via resolução do Conselho Federal de Biblioteconomia, porém não cumprem com o quesito profissional habilitado. Outra fragilidade evidenciada consiste no registro manual do acervo, como também, a principal fonte mantedora dos acervos ser o PNLD, ainda se constatou presença ínfima de e-books nos acervos das bibliotecas escolares. Por fim, destaca-se que a lei 12.244/2010 continua vigente e cabe aos Conselhos Regionais de Biblioteconomia, Ministério Público e a classe profissional bibliotecária vigiarem sua efetivação afim de contribuir com a qualidade da educação.

Published
2022

245. Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related disorders register

Author

Bergamaschi, R, Beghi, E, Bosetti, C, Ponzio, M, Santucci, C, Lepore, V, Mosconi, P, Aguglia, U, Amato, M, Ancona, A, Ardito, B, Avolio, C, Balgera, R, Banfi, P, Barcella, V, Barone, P, Bellantonio, P, Berardinelli, A, Bertora, P, Bianchi, M, Bramanti, P, Morra, V, Brichetto, G, Brioschi, A, Buccafusca, M, Bucello, S, Busillo, V, Calchetti, B, Cantello, R, Capobianco, M, Capone, F, Capone, L, Cargnelutti, D, Carrozzi, M, Cartechini, E, Cavaletti, G, Cavalla, P, Celani, M, Clerici, R, Clerico, M, Cocco, E, Confalonieri, P, Coniglio, M, Conte, A, Corea, F, Cottone, S, Crociani, P, D'Andrea, F, Danni, M, De Luca, G, de Pascalis, D, De Riz, M, De Robertis, F, De Rosa, G, De Stefano, N, Corte, M, Di Sapio, A, Docimo, R, Falcini, M, Falcone, N, Fermi, S, Ferraro, E, Ferrò, M, Fortunato, M, Foschi, M, Gajofatto, A, Gallo, A, Gallo, P, Gatto, M, Gazzola, P, Giordano, A, Granella, F, Grasso, M, Grimaldi, L, Iaffaldano, P, Imperiale, D, Inglese, M, Iodice, R, Leva, S, Luezzi, V, Lugaresi, A, Lus, G, Maimone, D, Mancinelli, L, Maniscalco, G, Marfia, G, Marini, B, Marson, A, Mascoli, N, Massacesi, L, Melani, F, Merello, M, Meucci, G, Mirabella, M, Montepietra, S, Nasuelli, D, Nicolao, P, Passantino, F, Patti, F, Peresson, M, Pesci, I, Piantadosi, C, Piras, M, Pizzorno, M, Plewnia, K, Pozzilli, C, Protti, A, Quatrale, R, Realmuto, S, Ribizzi, G, Rinalduzzi, S, Rini, A, Romano, S, Romeo, M, Ronzoni, M, Rossi, P, Rovaris, M, Salemi, G, Santangelo, G, Santangelo, M, Santuccio, G, Sarchielli, P, Sinisi, L, Sola, P, Solaro, C, Spitaleri, D, Strumia, S, Tassinari, T, Tonietti, S, Tortorella, C, Totaro, R, Tozzo, A, Trivelli, G, Ulivelli, M, Valentino, P, Venturi, S, Vianello, M, Zaffaroni, M, Zarbo, R, Trojano, M, Battaglia, M, Pugliatti, M, Gasperini, C, Comi, G, Bergamaschi, Roberto, Beghi, Ettore, Bosetti, Cristina, Ponzio, Michela, Santucci, Claudia, Lepore, Vito, Mosconi, Paola, Amato, M P, Ancona, A L, Morra, V Brescia, Brioschi, A M, Celani, M G, Coniglio, M G, Danni, M C, Corte, M Della, Ferrò, M T, Grasso, M F, Grasso, M G, Grimaldi, L M E, Maniscalco, G T, Marfia, G A, Piras, M L, Trojano, Maria, Battaglia, Mario Alberto, Capobianco, Marco, Pugliatti, Maura, Ulivelli, Monica, Gasperini, Claudio, Patti, Francesco, Amato, Maria Pia, Comi, Giancarlo, Bergamaschi, R, Beghi, E, Bosetti, C, Ponzio, M, Santucci, C, Lepore, V, Mosconi, P, Aguglia, U, Amato, M, Ancona, A, Ardito, B, Avolio, C, Balgera, R, Banfi, P, Barcella, V, Barone, P, Bellantonio, P, Berardinelli, A, Bertora, P, Bianchi, M, Bramanti, P, Morra, V, Brichetto, G, Brioschi, A, Buccafusca, M, Bucello, S, Busillo, V, Calchetti, B, Cantello, R, Capobianco, M, Capone, F, Capone, L, Cargnelutti, D, Carrozzi, M, Cartechini, E, Cavaletti, G, Cavalla, P, Celani, M, Clerici, R, Clerico, M, Cocco, E, Confalonieri, P, Coniglio, M, Conte, A, Corea, F, Cottone, S, Crociani, P, D'Andrea, F, Danni, M, De Luca, G, de Pascalis, D, De Riz, M, De Robertis, F, De Rosa, G, De Stefano, N, Corte, M, Di Sapio, A, Docimo, R, Falcini, M, Falcone, N, Fermi, S, Ferraro, E, Ferrò, M, Fortunato, M, Foschi, M, Gajofatto, A, Gallo, A, Gallo, P, Gatto, M, Gazzola, P, Giordano, A, Granella, F, Grasso, M, Grimaldi, L, Iaffaldano, P, Imperiale, D, Inglese, M, Iodice, R, Leva, S, Luezzi, V, Lugaresi, A, Lus, G, Maimone, D, Mancinelli, L, Maniscalco, G, Marfia, G, Marini, B, Marson, A, Mascoli, N, Massacesi, L, Melani, F, Merello, M, Meucci, G, Mirabella, M, Montepietra, S, Nasuelli, D, Nicolao, P, Passantino, F, Patti, F, Peresson, M, Pesci, I, Piantadosi, C, Piras, M, Pizzorno, M, Plewnia, K, Pozzilli, C, Protti, A, Quatrale, R, Realmuto, S, Ribizzi, G, Rinalduzzi, S, Rini, A, Romano, S, Romeo, M, Ronzoni, M, Rossi, P, Rovaris, M, Salemi, G, Santangelo, G, Santangelo, M, Santuccio, G, Sarchielli, P, Sinisi, L, Sola, P, Solaro, C, Spitaleri, D, Strumia, S, Tassinari, T, Tonietti, S, Tortorella, C, Totaro, R, Tozzo, A, Trivelli, G, Ulivelli, M, Valentino, P, Venturi, S, Vianello, M, Zaffaroni, M, Zarbo, R, Trojano, M, Battaglia, M, Pugliatti, M, Gasperini, C, Comi, G, Bergamaschi, Roberto, Beghi, Ettore, Bosetti, Cristina, Ponzio, Michela, Santucci, Claudia, Lepore, Vito, Mosconi, Paola, Amato, M P, Ancona, A L, Morra, V Brescia, Brioschi, A M, Celani, M G, Coniglio, M G, Danni, M C, Corte, M Della, Ferrò, M T, Grasso, M F, Grasso, M G, Grimaldi, L M E, Maniscalco, G T, Marfia, G A, Piras, M L, Trojano, Maria, Battaglia, Mario Alberto, Capobianco, Marco, Pugliatti, Maura, Ulivelli, Monica, Gasperini, Claudio, Patti, Francesco, Amato, Maria Pia, and Comi, Giancarlo

Abstract

Background: Multiple sclerosis (MS) is characterized by phenotypical heterogeneity, partly resulting from demographic and environmental risk factors. Socio-economic factors and the characteristics of local MS facilities might also play a part. Methods: This study included patients with a confirmed MS diagnosis enrolled in the Italian MS and Related Disorders Register in 2000–2021. Patients at first visit were classified as having a clinically isolated syndrome (CIS), relapsing–remitting (RR), primary progressive (PP), progressive-relapsing (PR), or secondary progressive MS (SP). Demographic and clinical characteristics were analyzed, with centers’ characteristics, geographic macro-areas, and Deprivation Index. We computed the odds ratios (OR) for CIS, PP/PR, and SP phenotypes, compared to the RR, using multivariate, multinomial, mixed effects logistic regression models. Results: In all 35,243 patients from 106 centers were included. The OR of presenting more advanced MS phenotypes than the RR phenotype at first visit significantly diminished in relation to calendar period. Females were at a significantly lower risk of a PP/PR or SP phenotype. Older age was associated with CIS, PP/PR, and SP. The risk of a longer interval between disease onset and first visit was lower for the CIS phenotype, but higher for PP/PR and SP. The probability of SP at first visit was greater in the South of Italy. Discussion: Differences in the phenotype of MS patients first seen in Italian centers can be only partly explained by differences in the centers’ characteristics. The demographic and socio-economic characteristics of MS patients seem to be the main determinants of the phenotypes at first referral.

Published
2022

246. La disputa radical. Unionistas e intransigentes en los años peronistas (1946-1955)

Author

Pizzorno, Pablo and Pizzorno, Pablo

Abstract

This paper analyzes the dispute within the Radical Civic Union throughout the years it became the main opposition party to Peronism. The previous division between Unionists and Intransigents was resignified due to the anti- Peronist experience, deepening the dispute over the meaning of the Radical tradition that each sector claimed for itself. While Unionists remained faithful to the spirit of the Democratic Union and accompanied the growing opposition radicalization, Intransigents tried to dispute the national and popular discourse of a government whose victory they considered a consequence of the loss of Radical identity., Este trabajo analiza la disputa interna librada en la Unión Cívica Radical durante los años en los que el partido se erigió como principal fuerza de oposición al peronismo. La división previa entre unionistas e intransigentes se resignificó debido a la experiencia antiperonista, y se profundizó la disputa en torno al sentido de la tradición radical que cada sector reivindicó para sí. Mientras los unionistas se mantuvieron fieles al espíritu de la Unión Democrática y acompañaron la creciente radicalización opositora, los intransigentes procuraron disputar las credenciales nacionales y populares de un gobierno cuya aparición consideraban fruto del extravío de la identidad radical.

Published
2022

247. Las patas en la fuente y la comunidad organizada: dislocación comunitaria e identidad en los orígenes del peronismo

Author

Pablo Pizzorno

Subjects
peronismo, identidades políticas, deferencia, populismo, Ethnology. Social and cultural anthropology, GN301-674
Abstract

El presente trabajo se concentra en el proceso de constitución identitaria del peronismo, retomando el lugar que ocupa la identidad en determinados estudios canónicos sobre los orígenes del peronismo y en clave de respuesta a los límites de las explicaciones basadas en el racionalismo instrumental. A partir de allí, se indaga en la conformación de un nuevo sujeto popular, articulado a partir de la interpelación peronista e identificado en la representación con Perón, cuya emergencia agrietó decisivamente el orden tradicional. Dicho proceso se plasmó en la llamada “crisis de la deferencia”, entendida como el fin de la aceptación de un lugar establecido en un orden hegemónico, expresando así un quiebre de los lugares asignados previamente en la comunidad política. Esta dislocación comunitaria de origen marcó constitutivamente al régimen peronista –donde convivieron tensamente tendencias orientadas al orden y a la ruptura– atentando contra los intentos de sutura estatal de aquella ruptura inicial. Esta última reflexión es guiada por el aporte de una serie de teorizaciones sobre el populismo como matriz específica en el marco de las Identidades políticas.

Published
2013

248. Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation[S]

Author

Thuc T. Le, Amy Ziemba, Yasuyo Urasaki, Eugene Hayes, Steven Brotman, and Giuseppe Pizzorno

Subjects
CARS microscopy, fatty liver, hepatic microvesicular steatosis, liver lipid metabolism, protein acetylation, uridine phosphorylase, Biochemistry, QD415-436
Abstract

We report in this study an intrinsic link between pyrimidine metabolism and liver lipid accumulation utilizing a uridine phosphorylase 1 transgenic mouse model UPase1-TG. Hepatic microvesicular steatosis is induced by disruption of uridine homeostasis through transgenic overexpression of UPase1, an enzyme of the pyrimidine catabolism and salvage pathway. Microvesicular steatosis is also induced by the inhibition of dihydroorotate dehydrogenase (DHODH), an enzyme of the de novo pyrimidine biosynthesis pathway. Interestingly, uridine supplementation completely suppresses microvesicular steatosis in both scenarios. The effective concentration (EC50) for uridine to suppress microvesicular steatosis is approximately 20 µM in primary hepatocytes of UPase1-TG mice. We find that uridine does not have any effect on in vitro DHODH enzymatic activity. On the other hand, uridine supplementation alters the liver NAD+/NADH and NADP+/NADPH ratios and the acetylation profile of metabolic, oxidation-reduction, and antioxidation enzymes. Protein acetylation is emerging as a key regulatory mechanism for cellular metabolism. Therefore, we propose that uridine suppresses fatty liver by modulating the liver protein acetylation profile. Our findings reveal a novel link between uridine homeostasis, pyrimidine metabolism, and liver lipid metabolism.

Published
2013
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