201. Non-infectious rhinitis is more strongly associated with early—rather than late—onset of COPD: data from the European Community Respiratory Health Survey (ECRHS).
- Author
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Bergqvist, Joel, Andersson, Anders, Schiöler, Linus, Olin, Anna-Carin, Murgia, Nicola, Bove, Mogens, Janson, Christer, Abramson, Michael J., Leynaert, Bénédicte, Nowak, Dennis, Franklin, Karl A., PIN, Isabelle, Storaas, Torgeir, Schlünssen, Vivi, Heinrich, Joachim, and Hellgren, Johan
- Subjects
OBSTRUCTIVE lung diseases ,RHINITIS ,EUROPEAN communities ,HEALTH surveys ,PUBLIC health ,ALLERGIC rhinitis - Abstract
Purpose: Chronic obstructive pulmonary disease (COPD) is associated with several co-morbidities and non-infectious rhinitis (NIR) has emerged as a new possible co-morbidity. The primary aim of this study is to confirm a previously reported association between NIR and COPD in a multicentre population over time. The secondary aim is to investigate the course over time of such an association through a comparison between early- and late-onset COPD. Methods: This study is part of the European Community Respiratory Health Survey (ECRHS). A random adult population from 25 centres in Europe and one in Australia was examined with spirometry and answered a respiratory questionnaire in 1998–2002 (ECRHS II) and in 2008–2013 (ECRHS III). Symptoms of non-infectious rhinitis, hay fever and asthma, and smoking habits were reported. Subjects reporting asthma were excluded. COPD was defined as a spirometry ratio of FEV
1 /FVC < 0.7. A total of 5901 subjects were included. Results: Non-infectious rhinitis was significantly more prevalent in subjects with COPD compared with no COPD (48.9% vs 37.1%, p < 0.001) in ECRHS II (mean age 43) but not in ECHRS III (mean age 54). In the multivariable regression model adjusted for COPD, smoking, age, BMI, and gender, non-infectious rhinitis was associated with COPD in both ECRHS II and III. Conclusion: Non-infectious rhinitis was significantly more common in subjects with COPD at a mean age of 43. Ten years later, the association was weaker. The findings indicate that NIR could be associated with the early onset of COPD. [ABSTRACT FROM AUTHOR]- Published
- 2020
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