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202. Losing Ground

Author

Phelps, Edmund, Hoon, Hian Teck, Zoega, Gylfi, Phelps, Edmund, Hoon, Hian Teck, and Zoega, Gylfi

Published
2023
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203. Economic Policies

Author

Phelps, Edmund, Hoon, Hian Teck, Zoega, Gylfi, Phelps, Edmund, Hoon, Hian Teck, and Zoega, Gylfi

Published
2023
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207. Innovation

Author

Phelps, Edmund, Hoon, Hian Teck, Zoega, Gylfi, Phelps, Edmund, Hoon, Hian Teck, and Zoega, Gylfi

Published
2023
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209. Reconceptualizing School Safety for Black Students

Author

Heidelburg, Kamontá, Phelps, Chavez, and Collins, Tai A.

Abstract

Ensuring a psychologically and physically safe learning environment for students and staff is necessary for students to learn and grow and for teachers to teach. However, for Black students and other marginalized students, the school environment is often physically and emotionally unsafe and they are targeted by anti-Black policies and practices, ultimately producing inequitable outcomes. As such, school safety must be reexamined and reconceptualized to promote a safe, secure, and welcoming environment for Black students. In this article, we will discuss the school-based experiences of Black students in American schools with a particular focus on Black students' physical and emotional safety. Furthermore, implications and recommendations for establishing safe, affirming, and culturally relevant educational spaces for Black students are provided.

Published
2022
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210. Identifying Patient Characteristics to Understand Which Children May Receive Diagnostic Clarity in a Virtual Autism Spectrum Disorder Evaluation

Author

Phelps, Randi A., Sample, Erika, Greene, Rachel K., and Duvall, Susanne W.

Abstract

Given long waitlists for autism spectrum disorder (ASD) evaluation coupled with the COVID-19 pandemic, it is crucial to triage patients to services they are likely to receive diagnostic clarity (i.e., virtual, in-person evaluation). Participants attended a virtual ASD assessment. A subset also attended in-person evaluation. Results suggest younger children with educational services for ASD may benefit from virtual assessment while older patients with a history of psychiatric conditions may benefit from in-person evaluation. An ASD symptom severity tool related to virtual and in-person diagnostic clarity. Family history of ASD related to in-person diagnosis while other variables (e.g., age, educational services) did not. The study suggests patient characteristics may be used to determine for whom virtual ASD assessment may be appropriate.

Published
2022
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211. Measurement of charged-pion production in deep-inelastic scattering off nuclei with the CLAS detector

Author

Moran, S., Dupre, R., Hakobyan, H., Arratia, M., Brooks, W. K., Borquez, A., Alaoui, A. El, Fassi, L. El, Hafidi, K., Mendez, R., Mineeva, T., Paul, S. J., Amaryan, M. J., Angelini, Giovanni, Armstrong, Whitney R., Atac, H., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benmokhtar, Fatiha, Bianconi, A., Biondo, L., Biselli, A. S., Bossu, F., Boiarinov, S., Briscoe, W. J., Bulumulla, D., Burkert, V. D., Carman, D. S., Chatagnon, P., Chesnokov, V., Chetry, T., Ciullo, G., Cole, P. L., Contalbrigo, M., Costantini, G., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Diehl, S., Djalali, C., Egiyan, H., Elouadrhiri, L., Eugenio, P., Fersch, R., Filippi, A., Gavalian, G., Ghandilyan, Y., Gilfoyle, G. P., Golubenko, A. A., Gothe, R. W., Griffioen, K. A., Guidal, M., Hattawy, M., Hauenstein, F., Hayward, T. B., Heddle, D., Hicks, K., Hobart, A., Holtrop, M., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jo, H. S., Keller, D., Khanal, A., Khandaker, M., Kim, W., Klein, F. J., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lanza, L., Leali, M., Lenisa, P., Livingston, K., MacGregor, I. J . D., Marchand, D., Marsicano, L., Mascagna, V., McKinnon, B., McLauchlin, C., Meziani, Z. E., Migliorati, S., Mirazita, M., Mokeev, V., Camacho, C. Munoz, Nadel-Turonski, P., Neupane, K., Niccolai, S., Niculescu, G., O'Connell, T. R., Osipenko, M., Ostrovidov, A. I., Ouillon, M., Pandey, P., Paolone, M., Pappalardo, L. L., Pasyuk, E., Phelps, W., Pogorelko, O., Poudel, J., Price, J. W., Prok, Y., Raue, B. A., Reed, Trevor, Ripani, M., Ritman, J., Rizzo, A., Rosner, G., Rowley, J., Sabatie, F., Salgado, C., Schmidt, A., Schumacher, R. A., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Sokhan, D., Soto, O., Sparveris, N., Stepanyan, S., Strakovsky, I. I., Strauch, S., Tyson, R., Ungaro, M., Venturelli, L., Voskanyan, H., Vossen, A., Voutier, E., Watts, D. P., Wei, Kevin, Wei, X., Weinstein, L. B., Wishart, R., Wood, M. H., Yale, B., Zachariou, N., Zhang, J., and Zhao, Z. W.

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

Background: Energetic quarks in nuclear DIS propagate through the nuclear medium. Processes that are believed to occur inside nuclei include quark energy loss through medium-stimulated gluon bremsstrahlung and intra-nuclear interactions of forming hadrons. More data are required to gain a more complete understanding of these effects. Purpose: To test the theoretical models of parton transport and hadron formation, we compared their predictions for the nuclear and kinematic dependence of pion production in nuclei. Methods: We have measured charged-pion production in semi-inclusive DIS off D, C, Fe, and Pb using the CLAS detector and the CEBAF 5.014 GeV electron beam. We report results on the nuclear-to-deuterium multiplicity ratio for $\pi^{+}$ and $\pi^{-}$ as a function of energy transfer, four-momentum transfer, and pion energy fraction or transverse momentum - the first three-dimensional study of its kind. Results: The $\pi^{+}$ multiplicity ratio is found to depend strongly on the pion fractional energy $z$, and reaches minimum values of $0.67\pm0.03$, $0.43\pm0.02$, and $0.27\pm0.01$ for the C, Fe, and Pb targets, respectively. The $z$ dependences of the multiplicity ratios for $\pi^{+}$ and $\pi^{-}$ are equal within uncertainties for C and Fe targets but show differences at the level of 10$\%$ for the Pb-target data. The results are qualitatively described by the GiBUU transport model, as well as with a model based on hadron absorption, but are in tension with calculations based on nuclear fragmentation functions. Conclusions: These precise results will strongly constrain the kinematic and flavor dependence of nuclear effects in hadron production, probing an unexplored kinematic region. They will help to reveal how the nucleus reacts to a fast quark, thereby shedding light on its color structure, transport properties, and on the mechanisms of the hadronization process., Comment: 22 pages, 5 figures, 12 tables

Published
2021
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212. General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants

Author

Zhou, Bin, Bennett, James E, Wickham, Aidan P, Singleton, Rosie K, Mishra, Anu, Carrillo-Larco, Rodrigo M, Ikeda, Nayu, Jain, Lakshya, Barradas-Pires, Ana, Heap, Rachel A, Lhoste, Victor PF, Sheffer, Kate E, Phelps, Nowell H, Rayner, Archie W, Gregg, Edward W, Woodward, Mark, Stevens, Gretchen A, Iurilli, Maria LC, Danaei, Goodarz, Di Cesare, Mariachiara, Aguilar-Salinas, Carlos A, Ahmad, Noor Ani, Bovet, Pascal, Chen, Zhengming, Damasceno, Albertino, Filippi, Sarah L, Janszky, Imre, Kengne, Andre P, Khang, Young-Ho, Khunti, Kamlesh, Laxmaiah, Avula, Lim, Lee-Ling, Lissner, Lauren, Margozzini, Paula, Mbanya, Jean Claude N, McGarvey, Stephen T, Shaw, Jonathan E, Söderberg, Stefan, Soto-Mota, Luis Adrián, Wang, Junyang, Zaccardi, Francesco, Abarca-Gómez, Leandra, Abbasi-Kangevari, Mohsen, Abdrakhmanova, Shynar, Abdul Ghaffar, Suhaila, Abdul Rahim, Hanan F, Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Aekplakorn, Wichai, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Hinai, Halima, Al-Lawati, Jawad A, Al-Raddadi, Rajaa, Al Asfoor, Deena, Al Hourani, Huda M, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M, Alieva, Anna V, Alkandari, Abdullah, Alkhatib, Buthaina M, Aly, Eman, Amarapurkar, Deepak N, Amiano Etxezarreta, Pilar, Amougou, Norbert, Andersen, Lars Bo, Anderssen, Sigmund A, Androutsos, Odysseas, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Anufrieva, Elena, Aounallah-Skhiri, Hajer, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Assah, Felix K, Assembekov, Batyrbek, Assunção, Maria Cecília F, Auvinen, Juha, Avdičová, Mária, Azad, Kishwar, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Bacopoulou, Flora, Bahijri, Suhad, Bajramovic, Izet, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, José R, Baran, Rafał, Barbagallo, Carlo M, Barbosa Filho, Valter, Barceló, Alberto, Baretić, Maja, Barnoya, Joaquin, Barrera, Lena, Barros, Aluisio JD, Barros, Mauro Virgílio Gomes, Basit, Abdul, Bastos, Joao Luiz, Batieha, Anwar M, Batista, Aline P, Batista, Rosangela L, Battakova, Zhamilya, Baur, Louise A, Bayauli, Pascal M, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedek, Theodora, Benedics, Judith, Benet, Mikhail, Benitez Rolandi, Gilda Estela, Benzeval, Michaela, Bere, Elling, Berger, Nicolas, Bergh, Ingunn Holden, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bettiol, Heloísa, Beybey, Augustin F, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bhargava, Santosh K, Bika Lele, Elysée Claude, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Björkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boggia, Jose G, Bogova, Elena, Bonaccio, Marialaura, Bonilla-Vargas, Alice, Borghs, Herman, Botomba, Steve, Bourne, Rupert, Boymatova, Khadichamo, Braeckman, Lutgart, Braithwaite, Tasanee, Brajkovich, Imperia, Branca, Francesco, Brenner, Hermann, Brewster, Lizzy M, Briceño, Yajaira, Brinduse, Lacramioara, Bringolf-Isler, Bettina, Brito, Miguel, Brug, Johannes, Bugge, Anna, Buntinx, Frank, Buoncristiano, Marta, Burns, Con, Cabrera de León, Antonio, Caixeta, Roberta B, Cama, Tilema, Can, Günay, Cândido, Ana Paula C, Cañete, Felicia, Capanzana, Mario V, Čapková, Naděžda, Capuano, Eduardo, Capuano, Rocco, Capuano, Vincenzo, Cardoso, Viviane C, Carlsson, Axel C, Casanueva, Felipe F, Casas, Maribel, Censi, Laura, Cervantes‐Loaiza, Marvin, Chamnan, Parinya, Chamukuttan, Snehalatha, Chan, Queenie, Chaturvedi, Nish, Chen, Fangfang, Chen, Huashuai, Chen, Long-Sheng, Cheng, Yiling J, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chinapaw, Mai JM, Chinnock, Anne, Chiolero, Arnaud, Chirita-Emandi, Adela, Chirlaque, María-Dolores, Chong, Chean Lin, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cirillo, Massimo, Claessens, Frank, Clare, Philip, Cohen, Emmanuel, Confortin, Susana C, Coppinger, Tara C, Cortés, Lilia Yadira, Cosmin, Cojocaru R, Costanzo, Simona, Cowan, Melanie J, Cowell, Chris, Crampin, Amelia C, Cross, Amanda J, Crujeiras, Ana B, Cruz, Juan J, Cucu, Alexandra M, Cureau, Felipe V, Cuschieri, Sarah, D'Arrigo, Graziella, d'Orsi, Eleonora, da Silva-Ferreira, Haroldo, Dahm, Christina C, Dallongeville, Jean, Dankner, Rachel, Davletov, Kairat, de Assis Guedes de Vasconcelos, Francisco, de Assis, Maria Alice Altenburg, De Bacquer, Dirk, De Bacquer, Jaco, de Bont, Jeroen, De Curtis, Amalia, de Fragas Hinnig, Patrícia, de Gaetano, Giovanni, De Henauw, Stefaan, De Miguel-Etayo, Pilar, de Oliveira, Paula Duarte, de Paiva, Karina Mary, De Ridder, Karin, de Valois Correia Júnior, Marco Aurélio, Deepa, Mohan, DeGennaro, Vincent Jr, Demarest, Stefaan, Dennison, Elaine, Deschamps, Valérie, Dhimal, Meghnath, Díez Ripollés, María Pilar, Dika, Zivka, Djalalinia, Shirin, Dominguez, Liria, Donati, Maria Benedetta, Donfrancesco, Chiara, Dong, Guanghui, Donoso, Silvana P, Dorobantu, Maria, Dörr, Marcus, Dragano, Nico, Drygas, Wojciech, Du, Shufa, Duante, Charmaine A, Duboz, Priscilla, Duda, Rosemary B, Duleva, Vesselka L, Dushpanova, Anar, Dyussupova, Azhar, Dziankowska-Zaborszczyk, Elzbieta, Ebrahimi, Narges, Echeverría, Guadalupe, Eddie, Ricky, Eftekhar, Ebrahim, Efthymiou, Vasiliki, Egbagbe, Eruke E, Eghtesad, Sareh, Ekelund, Ulf, El-Khateeb, Mohammad, El Ati, Jalila, Elosua, Roberto, Enang, Ofem, Erasmus, Rajiv T, Erem, Cihangir, Ergor, Gul, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Peña, Jorge, Esmaeili, Ali, Evans, Roger G, Fakhradiyev, Ildar, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Farzadfar, Farshad, Farzi, Yosef, Fattahi, Mohammad Reza, Fawwad, Asher, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernández-Bergés, Daniel, Fernando, Desha R, Ferrante, Daniel, Ferrari, Gerson, Ferrari, Marika, Ferreccio, Catterina, Ferrer, Eldridge, Figueiró, Thamara Hubler, Fijalkowska, Anna, Fink, Günther, Fisberg, Mauro, Forsner, Maria, Fottrell, Edward F, Fouad, Heba M, Francis, Damian K, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Furdela, Viktoriya, Furusawa, Takuro, Gabriela, Stefan Adela, Gaciong, Zbigniew, Galán Cuesta, Manuel, Galbarczyk, Andrzej, Galcheva, Sonya V, Galfo, Myriam, Garcia-de-la-Hera, Manoli, Garcia, Pablo, Garnett, Sarah P, Gasull, Magda, Gazzinelli, Andrea, Gehring, Ulrike, Gerdts, Eva, Ghaderi, Ebrahim, Ghamari, Seyyed-Hadi, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Ghimire, Anup, Gialluisi, Alessandro, Giampaoli, Simona, Gianfagna, Francesco, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Glushkova, Natalya, Godara, Ramesh, Godos, Justyna, Goldberg, Marcel, Gómez, Georgina, Gómez Gómez, Jesús Humberto, Gomez, Luis F, Gómez, Santiago F, Gomula, Aleksandra, Gonçalves Cordeiro da Silva, Bruna, Gonçalves, Helen, Gonçalves, Mauer, González-Alvarez, Ana D, Gonzalez-Chica, David A, González-Gil, Esther M, Gonzalez-Gross, Marcela, González-Rivas, Juan P, Gonzalez, Angel R, Gottrand, Frederic, Grafnetter, Dušan, Grajda, Aneta, Grammatikopoulou, Maria G, Grodzicki, Tomasz, Grøholt, Else Karin, Grøntved, Anders, Guajardo, Viviana, Guallar-Castillón, Pilar, Guerchet, Maëlenn, Guerrero, Ramiro, Guimaraes, Andre L, Gujral, Unjali P, Gulliford, Martin C, Gunter, Marc J, Gupta, Rajeev, Gureje, Oye, Gurinović, Mirjana A, Gurzkowska, Beata, Gutierrez, Laura, Gwee, Xinyi, Haghshenas, Rosa, Hakimi, Hamid, Halkjær, Jytte, Hambleton, Ian R, Hamzeh, Behrooz, Hanekom, Willem A, Hange, Dominique, Hanif, Abu AM, Hantunen, Sari, Hao, Jie, Hardman, Carla Menêses, Hardy, Louise, Hari Kumar, Rachakulla, Harooni, Javad, Hashemi-Shahri, Seyed Mohammad, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, Heinen, Mirjam, Hendriks, Marleen Elisabeth, Henrique, Rafael dos Santos, Henriques, Ana, Hernandez Cadena, Leticia, Herrala, Sauli, Herrera-Cuenca, Marianella, Herrera, Victor M, Herter-Aeberli, Isabelle, Herzig, Karl-Heinz, Heshmat, Ramin, Hill, Allan G, Ho, Sai Yin, Holdsworth, Michelle, Homayounfar, Reza, Homs, Clara, Hoogendijk, Emiel O, Horimoto, Andrea RVR, Hormiga, Claudia M, Horta, Bernardo L, Houti, Leila, Howitt, Christina, Htay, Thein Thein, Htet, Aung Soe, Htike, Maung Maung Than, Huerta, José María, Huhtaniemi, Ilpo Tapani, Huiart, Laetitia, Huidumac Petrescu, Constanta, Huisman, Martijn, Husseini, Abdullatif, Huybrechts, Inge, Hwalla, Nahla, Iacoviello, Licia, Iakupova, Ellina M, Iannone, Anna G, Igland, Jannicke, Ijoma, Chinwuba, Iotova, Violeta, Irazola, Vilma E, Ishida, Takafumi, Isiguzo, Godsent C, Islam, Muhammad, Islam, Sheikh Mohammed Shariful, Islek, Duygu, Ittermann, Till, Ivanova-Pandourska, Ivaila Y, Iwasaki, Masanori, Jääskeläinen, Tuija, Jackson, Rod T, Jaddou, Hashem Y, Jadoul, Michel, Jafar, Tazeen, Jan, Nataša, Janus, Edward, Jarani, Juel, Jarnig, Gerald, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jelaković, Ana, Jelaković, Bojan, Jha, Anjani Kumar, Jimenez, Ramon O, Jöckel, Karl-Heinz, Joffres, Michel, Jokelainen, Jari J, Jonas, Jost B, Joshi, Pradeep, Joshi, Rohina, Josipović, Josipa, Joukar, Farahnaz, Jóźwiak, Jacek J, Juolevi, Anne, Juresa, Vesna, Jureša, Vesna, Kaaks, Rudolf, Kaducu, Felix O, Kadvan, Agnes L, Kafatos, Anthony, Kajantie, Eero O, Kakutia, Natia, Kállayová, Daniela, Kalmatayeva, Zhanna, Kalter-Leibovici, Ofra, Kannan, Srinivasan, Kapantais, Efthymios, Karaglani, Eva, Karakosta, Argyro, Karki, Khem B, Kassi Anicet, Adoubi, Katibeh, Marzieh, Katulanda, Prasad, Katzmarzyk, Peter T, Kauhanen, Jussi, Kazakbaeva, Gyulli M, Kaze, François F, Ke, Calvin, Keinänen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kelleher, Cecily, Kemper, Han CG, Keramati, Maryam, Kersting, Mathilde, Khader, Yousef Saleh, Khaledifar, Arsalan, Khalili, Davood, Kheiri, Bahareh, Kheradmand, Motahareh, Khosravi, Alireza, Kiechl-Kohlendorfer, Ursula, Kiechl, Sophia J, Kiechl, Stefan, Kim, Hyeon Chang, Klakk, Heidi, Klanarong, Suntara, Klanova, Jana, Klimek, Magdalena, Knoflach, Michael, Kobel, Susanne, Koirala, Bhawesh, Kolle, Elin, Kolsteren, Patrick, König, Jürgen, Korpelainen, Raija, Korrovits, Paul, Korzycka, Magdalena, Kos, Jelena, Koskinen, Seppo, Koussoh Simone, Malik, Kovács, Éva, Kovalskys, Irina, Kowlessur, Sudhir, Koziel, Slawomir, Kratenova, Jana, Kratzer, Wolfgang, Kriemler, Susi, Kristensen, Peter Lund, Krizan, Helena, Kroker-Lobos, Maria F, Krokstad, Steinar, Kruger, Herculina S, Kruger, Ruan, Kryst, Łukasz, Kubinova, Ruzena, Kujala, Urho M, Kujundzic, Enisa, Kulaga, Zbigniew, Kulimbet, Mukhtar, Kumari, Meena, Kunešová, Marie, Kurjata, Pawel, Kyobutungi, Catherine, La, Quang Ngoc, Labadarios, Demetre, Lachat, Carl, Lai, Daphne, Laid, Youcef, Lall, Lachmie, Landaeta Jimenez, Maritza, Landais, Edwige, Lankila, Tiina, Lanska, Vera, Lappas, Georg, Larijani, Bagher, Lateva, Mina P, Latt, Tint Swe, Laurenzi, Martino, Lazo-Porras, Maria, Le Coroller, Gwenaëlle, Le Nguyen Bao, Khanh, Lehtimäki, Terho, Lemogoum, Daniel, Leong, Elvynna, Leszczak, Justyna, Leung, Gabriel M, Li, Yanping, Liivak, Merike, Lim, Charlie, Lim, Wei-Yen, Lima-Costa, M Fernanda, Lin, Hsien-Ho, Lind, Lars, Litwin, Mieczyslaw, Liu, Liping, Liu, Xiaotian, Longo Abril, Guadalupe, Lopes, Oscar, Lopez-Garcia, Esther, López-Gil, José Francisco, Lopez, Tania, Lozano, José Eugenio, Lukrafka, Janice L, Luksiene, Dalia, Lundqvist, Annamari, Lunet, Nuno, Lunogelo, Charles, Lustigová, Michala, M'Buyamba-Kabangu, Jean-René, Machado-Coelho, George LL, Machado-Rodrigues, Aristides M, Macia, Enguerran, Madar, Ahmed A, Maestre, Gladys E, Maggi, Stefania, Magliano, Dianna J, Magnacca, Sara, Magriplis, Emmanuella, Mahasampath, Gowri, Maire, Bernard, Makdisse, Marcia, Malekpour, Mohammad-Reza, Malekzadeh, Fatemeh, Malekzadeh, Reza, Mallikharjuna Rao, Kodavanti, Malyutina, Sofia, Maniego, Lynell V, Manios, Yannis, Mann, Jim I, Mansour-Ghanaei, Fariborz, Manzato, Enzo, Mapatano, Mala Ali, Maria-Magdalena, Rosu, Mariño, Joany, Markaki, Anastasia, Marques, Larissa Pruner, Marrugat, Jaume, Martorell, Reynaldo, Maruszczak, Katharina, Masala, Giovanna, Mascarenhas, Luis P, Masimango Imani, Mannix, Masinaei, Masoud, Mathiesen, Ellisiv B, Matijasevich, Alicia, Matłosz, Piotr, Matsha, Tandi E, Matsudo, Victor, Matteo, Giletta, Maulik, Pallab K, Mavrogianni, Christina, Mc Donald Posso, Anselmo J, McFarlane, Shelly R, McLean, Rachael M, Mediene Benchekor, Sounnia, Mehlig, Kirsten, Mehrparvar, Amir Houshang, Melgarejo, Jesus D, Méndez, Fabián, Mendivil, Carlos O, Mendoza Montano, Carlos, Menezes, Ana Maria B, Mensink, Gert BM, Mereke, Alibek, Meshram, Indrapal I, Meto, Diane T, Meyer, Haakon E, Mi, Jie, Miłkowska, Karolina, Miller, Jody C, Milushkina, Olga, Minderico, Cláudia S, Mini, GK, Miquel, Juan Francisco, Miranda, J Jaime, Mirjalili, Mohammad Reza, Mišigoj-Duraković, Marjeta, Mistretta, Antonio, Mocanu, Veronica, Modesti, Pietro A, Moghaddam, Sahar Saeedi, Mohammad, Kazem, Mohammadi, Mohammad Reza, Mohammadi, Zahra, Mohammadifard, Noushin, Mohammadpourhodki, Reza, Mohan, Viswanathan, Mohd Yusoff, Muhammad Fadhli, Mohebbi, Iraj, Møller, Niels C, Molnár, Dénes, Momenan, Amirabbas, Mondo, Charles K, Monroy-Valle, Michele M, Montenegro Mendoza, Roger A, Monterrubio-Flores, Eric, Monyeki, Kotsedi Daniel K, Moon, Jin Soo, Moosazadeh, Mahmood, Moradpour, Farhad, Moreira, Leila B, Morejon, Alain, Moreno, Luis A, Morgan, Karen, Moschonis, George, Moslem, Alireza, Mosquera, Mildrey, Mossakowska, Malgorzata, Mostafa, Aya, Mostafavi, Seyed-Ali, Motlagh, Mohammad Esmaeel, Motta, Jorge, Moura-dos-Santos, Marcos André, Mridha, Malay K, Msyamboza, Kelias P, Mu, Thet Thet, Muca, Florian, Mugoša, Boban, Munroe, Patricia B, Mursu, Jaakko, Musa, Kamarul Imran, Musić Milanović, Sanja, Musil, Vera, Musinguzi, Geofrey, Mustafa, Norlaila, Muyer, Muel Telo Marie-Claire, Nabipour, Iraj, Naidu, Balkish M, Najafi, Farid, Nalecz, Hanna, Námešná, Jana, Narayan, KM Venkat, Naseri, Take, Nathalie, Michels, Neelapaichit, Nareemarn, Nejatizadeh, Azim, Nenko, Ilona, Nervi, Flavio, Neuhauser, Hannelore K, Ng, Tze Pin, Nguyen, Chung T, Nguyen, Quang V, Nguyen, Quang Ngoc, Ni, Michael Y, Nie, Peng, Nieto-Martínez, Ramfis E, Niiranen, Teemu J, Ninomiya, Toshiharu, Nishi, Nobuo, Nishtar, Sania, Noale, Marianna, Noboa, Oscar A, Nogueira, Helena, Norton, Kevin I, Noto, Davide, Nowak-Szczepanska, Natalia, Nsour, Mohannad Al, Nuhoğlu, Irfan, Nurk, Eha, Nuwaha, Fred, Nyirenda, Moffat, O'Neill, Terence W, Ochimana, Caleb, Ochoa-Avilés, Angélica M, Oda, Eiji, Odili, Augustine N, Oh, Kyungwon, Ohtsuka, Ryutaro, Oldenburg, Brian, Olié, Valérie, Omar, Mohd Azahadi, Omar, Saeed M, Onat, Altan, Ong, Sok King, Onland-Moret, N Charlotte, Ono, Lariane M, Onodugo, Obinna, Ordunez, Pedro, Ornelas, Rui, Ortiz, Ana P, Ortiz, Pedro J, Osmond, Clive, Ostojic, Sergej M, Ostovar, Afshin, Otero, Johanna A, Ottendahl, Charlotte B, Otu, Akaninyene, Overvad, Kim, Owusu-Dabo, Ellis, Padez, Cristina P, Pagkalos, Ioannis, Pajula, Natalja, Palloni, Alberto, Palmieri, Luigi, Pan, Wen-Harn, Panza, Francesco, Paoli, Mariela, Papadopoulou, Sousana K, Pareja, Rossina G, Park, Soon-Woo, Park, Suyeon, Parnell, Winsome R, Parsaeian, Mahboubeh, Pascanu, Ionela M, Pasquet, Patrick, Patel, Nikhil D, Pavlyshyn, Halyna, Pechlaner, Raimund, Pećin, Ivan, Pedro, João M, Peixoto, Sergio Viana, Peltonen, Markku, Pereira, Alexandre C, Peres, Karen GDA, Peres, Marco A, Perez-Londoño, Agustín, Pérez, Cynthia M, Peterkova, Valentina, Petrovna Kovtun, Olga, Peykari, Niloofar, Pham, Son Thai, Pichardo, Rafael N, Pierre-Marie, Preux, Pikhart, Hynek, Pilav, Aida, Piler, Pavel, Piwonska, Aleksandra, Pizarro, Andreia N, Plata, Silvia, Pop, Raluca M, Popkin, Barry M, Popovic, Stevo R, Porta, Miquel, Poudyal, Anil, Pourfarzi, Farhad, Pourshams, Akram, Poustchi, Hossein, Pradeepa, Rajendra, Price, Alison J, Prista, Antonio, Providencia, Rui, Puder, Jardena J, Pudule, Iveta, Puhakka, Soile, Puiu, Maria, Punab, Margus, Qorbani, Mostafa, Quialheiro, Anna, Quintana, Hedley K, Quiroga-Padilla, Pedro J, Quoc Bao, Tran, Rach, Stefan, Rahimikazerooni, Salar, Rahman, Mahmudur, Raitakari, Olli, Rakhmatulloev, Sherali, Rakovac, Ivo, Ramachandran, Ambady, Ramadan, Otim PC, Ramirez-Zea, Manuel, Ramos, Rafel, Rampal, Lekhraj, Rampal, Sanjay, Ramsay, Sheena E, Rangel Junior, João FLB, Rangel Reina, Daniel A, Rangelova, Lalka S, Rarra, Vayia, Rashidi, Mohammad-Mahdi, Rech, Cassiano Ricardo, Redon, Josep, Regecová, Valéria, Renner, Jane DP, Repasy, Judit A, Reuter, Cézane P, Revilla, Luis, Reynolds, Andrew, Rezaei, Negar, Rezaianzadeh, Abbas, Riboli, Elio, Rigo, Fernando, Rigotti, Attilio, Riley, Leanne M, Rinke de Wit, Tobias F, Risérus, Ulf, Ritti-Dias, Raphael M, Roa, Reina G, Roccaldo, Romana, Rodríguez-Artalejo, Fernando, Rodriguez-Perez, María del Cristo, Rodríguez-Villamizar, Laura A, Rodríguez, Andrea Y, Roggenbuck, Ulla, Rohloff, Peter, Rojas-Martinez, Rosalba, Romeo, Elisabetta L, Rosario, Rafaela V, Rosengren, Annika, Rouse, Ian, Rubinstein, Adolfo, Ruiz-Betancourt, Blanca Sandra, Ruiz-Castell, Maria, Ruiz Moreno, Emma, Rusakova, Iuliia A, Rusek, Wojciech, Rust, Petra, Rutkowski, Marcin, Saamel, Marge, Sabbaghi, Hamideh, Sachdev, Harshpal S, Sadjadi, Alireza, Safarpour, Ali Reza, Safi, Sare, Saghi, Mohammad Hossien, Saidi, Olfa, Saieva, Calogero, Sakata, Satoko, Saki, Nader, Šalaj, Sanja, Salazar Martinez, Eduardo, Salkhanova, Akkumis, Salonen, Jukka T, Samoutian, Margarita, Sánchez-Abanto, Jose, Sánchez Rodríguez, Inés, Santos, Diana A, Santos, Ina S, Santos, Maria Paula, Santos, Tamara R, Saramies, Jouko L, Sardinha, Luis B, Sarganas, Giselle, Sarrafzadegan, Nizal, Saum, Kai-Uwe, Savin, Stefan, Sbaraini, Mariana, Scazufca, Marcia, Schaan, Beatriz D, Schienkiewitz, Anja, Schindler, Karin, Schipf, Sabine, Schmidt, Amand Floriaan, Schmidt, Börge, Schmidt, Carsten O, Schöttker, Ben, Schramm, Sara, Schramm, Stine, Schröder, Helmut, Schultsz, Constance, Schutte, Aletta E, Sebert, Sylvain, Sedaghattalab, Moslem, Sein, Aye Aye, Sen, Abhijit, Sepanlou, Sadaf G, Sequera, Guillermo, Ševčíková, Ľudmila, Sewpaul, Ronel, Shamah-Levy, Teresa, Shamshirgaran, Seyed Morteza, Sharafkhah, Maryam, Sharma, Sanjib K, Sharman, Almaz, Shayanrad, Amaneh, Shayesteh, Ali Akbar, Shengelia, Lela, Shibuya, Kenji, Shimizu-Furusawa, Hana, Shiri, Rahman, Shoranov, Marat, Shrestha, Namuna, Si-Ramlee, Khairil, Sibai, Abla M, Sidossis, Labros S, Silva, Antonio M, Silva, Caroline Ramos de Moura, Silva, Diego Augusto Santos, Silva, Kelly Samara, Sim, Xueling, Simon, Mary, Sjöström, Michael, Skoblina, Natalia A, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemysław, Smeeth, Liam, Smith, Lee, Soares, Fernanda Cunha, Sobek, Grzegorz, Sobngwi, Eugène, Sodemann, Morten, Soemantri, Agustinus, Solfrizzi, Vincenzo, Somi, Mohammad Hossein, Sørgjerd, Elin P, Sorić, Maroje, Soto-Rojas, Victoria E, Soumaré, Aïcha, Sousa-Poza, Alfonso, Spiroski, Igor, Staessen, Jan A, Stang, Andreas, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Stergiou, George S, Stokwiszewski, Jakub, Stoyanova, Ekaterina, Stratton, Gareth, Stronks, Karien, Sturua, Lela, Suarez-Ortegón, Milton F, Suebsamran, Phalakorn, Sulo, Gerhard, Sundström, Johan, Suriyawongpaisal, Paibul, Swinburn, Boyd A, Sylva, René Charles, Szponar, Lucjan, Tai, E Shyong, Tambalis, Konstantinos D, Tamosiunas, Abdonas, Tanabayev, Baimakhan, Tanrygulyyeva, Maya, Tarawneh, Mohammed Rasoul, Tarp, Jakob, Tarqui-Mamani, Carolina B, Taxová Braunerová, Radka, Te Velde, Saskia, Tebar, William R, Tell, Grethe S, Tello, Tania, Thankappan, KR, Theodoridis, Xenophon, Thirunavukkarasu, Sathish, Thomas, Nihal, Thrift, Amanda G, Tichá, Ľubica, Timmermans, Erik J, Tjandrarini, Dwi Hapsari, Tjonneland, Anne, Tolstrup, Janne S, Topbas, Murat, Torres-Collado, Laura, Touloumi, Giota, Traissac, Pierre, Triantafyllou, Areti, Trivedi, Atul, Tshepo, Lechaba, Tsintavis, Panagiotis, Tuitele, John, Tuliakova, Azaliia M, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Turley, Maria L, Tzala, Evangelia, Tzotzas, Themistoklis, Tzourio, Christophe, Ueda, Peter, Ugel, Eunice, Ukoli, Flora AM, Usupova, Zhamyila, Uusitalo, Hannu MT, Uysal, Nalan, Valdivia, Gonzalo, Valvi, Damaskini, van Dam, Rob M, van den Born, Bert-Jan, Van der Heyden, Johan, van der Schouw, Yvonne T, Van Lippevelde, Wendy, Van Minh, Hoang, Van Schoor, Natasja M, van Valkengoed, Irene GM, Vanderschueren, Dirk, Vanuzzo, Diego, Varela-Moreiras, Gregorio, Vargas, Luz Nayibe, Vasan, Senthil K, Vasques, Daniel G, Vega, Tomas, Velasquez-Melendez, Gustavo, Velika, Biruta, Verdot, Charlotte, Verloigne, Maïté, Veronesi, Giovanni, Verschuren, WM Monique, Verstraeten, Roosmarijn, Viet, Lucie, Vik, Frøydis N, Vilar, Monica, Villalpando, Salvador, Vioque, Jesus, Virtanen, Jyrki K, Visser, Marjolein, Viswanathan, Bharathi, Vladulescu, Mihaela, Völzke, Henry, Voutilainen, Ari, Vrijheid, Martine, Wade, Alisha N, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wanderley Júnior, Rildo de Souza, Wang, Chongjian, Wang, Huijun, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Wartha, Olivia, Weber, Adelheid, Webster-Kerr, Karen, Wedderkopp, Niels, Weghuber, Daniel, Wei, Wenbin, Westbury, Leo, Whincup, Peter H, Wickramasinghe, Kremlin, Widhalm, Kurt, Widyahening, Indah S, Więcek, Andrzej, Wilks, Rainford J, Willeit, Karin, Willeit, Peter, Williams, Julianne, Wilsgaard, Tom, Wojtyniak, Bogdan, Wong-McClure, Roy A, Wong, Andrew, Wong, Emily B, Wu, Frederick C, Wyszyńska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yan, Li, Yan, Weili, Yang, Yang, Yépez García, Martha, Yoosefi, Moein, Yoshihara, Akihiro, Younger-Coleman, Novie O, Yu, Yu-Ling, Yu, Yunjiang, Yusoff, Ahmad Faudzi, Zafiropulos, Vassilis, Zainuddin, Ahmad A, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zapata, Maria Elisa, Zaw, Ko Ko, Zdrojewski, Tomasz, Żegleń, Magdalena, Zejglicova, Kristyna, Zeljkovic Vrkic, Tajana, Zhang, Bing, Zhang, Zhen-Yu, Zhecheva, Yanitsa V, Zholdin, Bekbolat, Zimmet, Paul, Zins, Marie, Zuñiga Cisneros, Julio, Zuziak, Monika, and Ezzati, Majid

Published
2024
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219. Deep Learning-Based Detection and Classification of Bone Lesions on Staging Computed Tomography in Prostate Cancer: A Development Study

Author

Belue, Mason J., Harmon, Stephanie A., Yang, Dong, An, Julie Y., Gaur, Sonia, Law, Yan Mee, Turkbey, Evrim, Xu, Ziyue, Tetreault, Jesse, Lay, Nathan S., Yilmaz, Enis C., Phelps, Tim E., Simon, Benjamin, Lindenberg, Liza, Mena, Esther, Pinto, Peter A., Bagci, Ulas, Wood, Bradford J., Citrin, Deborah E., Dahut, William L., Madan, Ravi A., Gulley, James L., Xu, Daguang, Choyke, Peter L., and Turkbey, Baris

Published
2024
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220. MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57Kip2 targeting

Author

Pomella, Silvia, Cassandri, Matteo, D’Archivio, Lucrezia, Porrazzo, Antonella, Cossetti, Cristina, Phelps, Doris, Perrone, Clara, Pezzella, Michele, Cardinale, Antonella, Wachtel, Marco, Aloisi, Sara, Milewski, David, Colletti, Marta, Sreenivas, Prethish, Walters, Zoë S., Barillari, Giovanni, Di Giannatale, Angela, Milano, Giuseppe Maria, De Stefanis, Cristiano, Alaggio, Rita, Rodriguez-Rodriguez, Sonia, Carlesso, Nadia, Vakoc, Christopher R., Velardi, Enrico, Schafer, Beat W., Guccione, Ernesto, Gatz, Susanne A., Wasti, Ajla, Yohe, Marielle, Ignatius, Myron, Quintarelli, Concetta, Shipley, Janet, Miele, Lucio, Khan, Javed, Houghton, Peter J., Marampon, Francesco, Gryder, Berkley E., De Angelis, Biagio, Locatelli, Franco, and Rota, Rossella

Published
2023
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221. Endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle

Author

Sacharidou, Anastasia, Chambliss, Ken, Peng, Jun, Barrera, Jose, Tanigaki, Keiji, Luby-Phelps, Katherine, Özdemir, İpek, Khan, Sohaib, Sirsi, Shashank R., Kim, Sung Hoon, Katzenellenbogen, Benita S., Katzenellenbogen, John A., Kanchwala, Mohammed, Sathe, Adwait A., Lemoff, Andrew, Xing, Chao, Hoyt, Kenneth, Mineo, Chieko, and Shaul, Philip W.

Published
2023
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229. Neuropsychological consequences of COVID-19 : long COVID and the relationship with acute illness

Author

Phelps, Luke

Subjects
Neuropsychology, long COVID, COVID-19, cognitive and emotional consequences, coronavirus
Abstract

Rationale and aims: Long COVID has a substantial impact on quality of life for many, with international prevalence related to the worldwide COVID-19 pandemic. However, acute illness severity may not always predict the neuropsychological consequences in long COVID. This may be due to unique neurotropic mechanisms of the virus. Research to date has explored up to 12 months post infection but assessment is largely limited to screening and relies on cognitive testing alone to draw conclusions. Therefore, this research project aimed to answer two research questions: 'what are the objectively measured cognitive and emotional consequences of COVID-19/ long COVID at 20-24 months?' and 'how does this relate to the subjective experience of illness from COVID-19 and illness severity?' Methodology: A two-part sequential explanatory mixed-methods design was used, firstly with inferential statistics to analyse data from cognitive testing and self-report mood measures. Participants (n=19) were assessed 20-24 months post infection. Results were compared between two groups: those that accessed a virtual hospital service (n=9) during the acute stages and those that accessed a long COVID service (n=10) at some stage after. Thematic analysis captured information from questionnaire responses to enhance findings. Discussion: Many appear to recover cognitive function toward the 2-year mark, but some specific deficit in visuospatial, psychomotor and executive function was observed, which appears to be irrespective of illness severity. These concerns, often in combination with pandemic related concerns, had a substantial impact on quality of life for participants. Implications: Due to the varied cognitive profile and substantial impact of long COVID, future research should utilise comprehensive cognitive testing in combination with accounts of participants' experiences of symptoms. Long COVID services could consider neuropsychological expertise for individualised assessment and therapy intervention.

Published
2022
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230. Neural and behavioural effects of bilingualism on selective attention

Author

Phelps, Jacqueline and Bozic, Mirjana

Subjects
Bilingualism, Degeneracy, EEG, Selective attention
Abstract

Bilingualism has been shown to modulate the neural mechanisms of selective attention, with differences between monolinguals and bilinguals observed even when they display equivalent behavioural performance in a selective attention task. This suggests that the crucial consequence of learning and using multiple languages might be that it triggers neuroplastic adaptation that allows bilinguals to achieve optimal performance under increased processing demands. This functional plasticity yielding equivalent outcomes (also known as degeneracy) is a common feature in biological systems, allowing flexible adaptation to changing environments. Yet the exact mechanism by which bilingualism affects selective attention is still not entirely clear. While the currently dominant view suggests that the need for constant management of competing languages in bilinguals increases attentional capacity; another possibility is that this language control may be drawing on the available attentional resources such that they need to be economised to support optimal task performance. Another question concerns the development of this adaptation over time, where the demands of competition and inhibition between co-activated languages might be reconfiguring the patterns of attentional processes right from the onset, such that the effects can be seen by the time children can respond to selective attention tasks. Alternatively, these modifications might have a protracted maturation dependent on the length and intensity of exposure to the demands of bilingualism, in which case they would manifest differently in adults and in children, as well as in speakers with different levels of exposure to L2. Finally, another aspect is to establish the extent to which these modifications might affect attentional processing beyond the language domain, extending to auditory processing more generally. Here I present a series of behavioural and neuroimaging experiments that address these questions. To investigate whether bilingualism enhances attentional processing or triggers redistribution of the existing capacity, I used EEG to track the neural encoding of attended continuous speech in monolingual and bilingual children aged 7-12, in the context of different types of acoustic and linguistic interference. Participants attended to a narrative in English while four different types of interference were presented to the unattended ear. The neural encoding of attended and unattended streams was assessed by reconstructing their speech envelopes from the EEG data in each condition, using the mTRF toolbox. Results showed more accurate reconstruction of the attended envelopes than ignored ones across all conditions for both bilinguals and monolinguals. Critically however, there was no evidence of enhanced attentional processing in bilinguals; instead data showed a pattern consistent with redistribution of the available capacity, economised to achieve optimal performance on the selective attention task. The follow up behavioural experiments tested the limits of this adaptation by using a dual task (dichotic listening + visual attention) to further increase processing load. The results over three experiments (on children, and adults with different levels of exposure to L2) showed consistently comparable performance on both tasks for monolingual and bilingual adults, suggesting that bilingual adaptation can accommodate high processing loads. However there were also subtle differences in performance on the secondary (visual) task between the monolingual and bilingual children, and across the two groups of bilingual adults, suggesting that maturation and exposure do exert influence on this functional adaptation. The findings of the final EEG study on auditory processing beyond language domain indicate comparable but attenuated modification of attentional processing in bilinguals, compared to the first EEG study using linguistic interference. Findings from all experiments are explored in the context of theories of selective attention and bilingualism.

Published
2022
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231. The small molecule CBR-5884 inhibits the Candida albicans phosphatidylserine synthase

Author

Yue Zhou, Gregory A. Phelps, Mikayla M. Mangrum, Jemma McLeish, Elise K. Phillips, Jinchao Lou, Christelle F. Ancajas, Jeffrey M. Rybak, Peter M. Oelkers, Richard E. Lee, Michael D. Best, and Todd B. Reynolds

Subjects
Candida, phosphatidylserine, Cho1, CBR-5884, small-molecule screening, Microbiology, QR1-502
Abstract

ABSTRACTSystemic infections by Candida spp. are associated with high mortality rates, partly due to limitations in current antifungals, highlighting the need for novel drugs and drug targets. The fungal phosphatidylserine synthase, Cho1, from Candida albicans is a logical antifungal drug target due to its importance in virulence, absence in the host, and conservation among fungal pathogens. Inhibitors of Cho1 could serve as lead compounds for drug development, so we developed a target-based screen for inhibitors of purified Cho1. This enzyme condenses serine and cytidyldiphosphate-diacylglycerol (CDP-DAG) into phosphatidylserine (PS) and releases cytidylmonophosphate (CMP). Accordingly, we developed an in vitro nucleotidase-coupled malachite-green-based high throughput assay for purified C. albicans Cho1 that monitors CMP production as a proxy for PS synthesis. Over 7,300 molecules curated from repurposing chemical libraries were interrogated in primary and dose-responsivity assays using this platform. The screen had a promising average Z’ score of ~0.8, and seven compounds were identified that inhibit Cho1. Three of these, ebselen, LOC14, and CBR-5884, exhibited antifungal effects against C. albicans cells, with fungicidal inhibition by ebselen and fungistatic inhibition by LOC14 and CBR-5884. Only CBR-5884 showed evidence of disrupting in vivo Cho1 function by inducing phenotypes consistent with the cho1∆∆ mutant, including a reduction of cellular PS levels. Kinetics curves and computational docking indicate that CBR-5884 competes with serine for binding to Cho1 with a Ki of 1,550 ± 245.6 nM. Thus, this compound has the potential for development into an antifungal compound.IMPORTANCEFungal phosphatidylserine synthase (Cho1) is a logical antifungal target due to its crucial role in the virulence and viability of various fungal pathogens, and since it is absent in humans, drugs targeted at Cho1 are less likely to cause toxicity in patients. Using fungal Cho1 as a model, there have been two unsuccessful attempts to discover inhibitors for Cho1 homologs in whole-cell screens prior to this study. The compounds identified in these attempts do not act directly on the protein, resulting in the absence of known Cho1 inhibitors. The significance of our research is that we developed a high-throughput target-based assay and identified the first Cho1 inhibitor, CBR-5884, which acts both on the purified protein and its function in the cell. This molecule acts as a competitive inhibitor with a Ki value of 1,550 ± 245.6 nM and, thus, has the potential for development into a new class of antifungals targeting PS synthase.

Published
2024
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232. Streamside detection of Chinook salmon (Oncorhynchus tshawytscha) environmental DNA with CRISPR technology

Author

Tholen Blasko and Michael Phelps

Subjects
CRISPR‐Cas systems, environmental DNA, ecosystem, fisheries, RNA, Salmon, Environmental sciences, GE1-350, Microbial ecology, QR100-130
Abstract

Abstract There is a rapidly growing interest by resource managers to utilize environmental DNA technology (eDNA) as a tool to enhance current management efforts. However, the technology remains relatively specialized, since it requires specific expertise and equipment to perform. To begin to overcome some of the obstacles restricting the widespread, routine adoption of eDNA technology, we evaluated the use of CRISPR Cas12a detection technology for in‐the‐field eDNA detection using Chinook salmon (Oncorhynchus tshawytscha) as a target species. By targeting a highly variable region in the salmonid mitochondrial DNA D‐loop, we were able to demonstrate that CRISPR Cas12a detection technology is both sensitive and specific for Chinook salmon eDNA. Engineering of the technology to work in the field was accomplished by employing rapid eDNA purification and visual readout of results using visual lateral flow or fluorescent detection methods. The technology was piloted on the fall Chinook salmon run in the Snake River of Washington State, USA, and proved to be a viable approach for streamside eDNA monitoring. With the improvement of the technology, CRISPR eDNA detection methods hold great promise in expanding the reach of eDNA as a commonly used resource management tool.

Published
2024
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233. Can researchers trust ICD-10 coding of medical comorbidities in orthopaedic trauma patients?

Author

Rodney Arthur, BS, R. Miles Mayberry, BS, Susan Odum, PhD, Laurence B. Kempton, MD, Evidence-Based Musculoskeletal Injury and Trauma Collaborative (EMIT), Rachel B. Seymour, Priyanka Kamath, Christina Churchill, Meghan K. Wally, Meera Sumith, Joseph R. Hsu, Madhav Karunakar, Kevin D. Phelps, Stephen H. Sims, and Suman Medda

Subjects
Orthopedic surgery, RD701-811
Abstract

Abstract. Objectives:. The 10th revision of the International Classification of Diseases (ICD-10) coding system may prove useful to orthopaedic trauma researchers to identify and document populations based on comorbidities. However, its use for research first necessitates determination of its reliability. The purpose of this study was to assess the reliability of electronic medical record (EMR) ICD-10 coding of nonorthopaedic diagnoses in orthopaedic trauma patients relative to the gold standard of prospective data collection. Design:. Nonexperimental cross-sectional study. Setting:. Level 1 Trauma Center. Patients/Participants:. Two hundred sixty-three orthopaedic trauma patients from 2 prior prospective studies from September 2018 to April 2022. Intervention:. Prospectively collected data were compared with EMR ICD-10 code abstraction for components of the Charlson Comorbidity Index (CCI), obesity, alcohol abuse, and tobacco use (retrospective data). Main Outcome Measurements:. Percent agreement and Cohen's kappa reliability. Results:. Percent agreement ranged from 86.7% to 96.9% for all CCI diagnoses and was as low as 72.6% for the diagnosis “overweight.” Only 2 diagnoses, diabetes without end-organ damage (kappa = 0.794) and AIDS (kappa = 0.798) demonstrated Cohen's kappa values to indicate substantial agreement. Conclusion:. EMR diagnostic coding for medical comorbidities in orthopaedic trauma patients demonstrated variable reliability. Researchers may be able to rely on EMR coding to identify patients with diabetes without complications or AIDS. Chart review may still be necessary to confirm diagnoses. Low prevalence of most comorbidities led to high percentage agreement with low reliability. Level of Evidence:. Level 1 diagnostic.

Published
2024
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234. Learning from (re)experience: What mobile eye-tracking video can help us learn about the cognitive processes of teaching

Author

Kevin F. Miller, Chris Correa, Kai Cortina, Lauren Phelps, and Lynn Chamberlain

Subjects
teacher vision, mobile eye-tracking, expertise, professional development, video, teacher thinking, Education (General), L7-991
Abstract

IntroductionClassroom teachers need to monitor a group of students varying in interest, knowledge, and behavior at the same time that they present a lesson and adapt it on the fly to student questions and understanding. Many areas of expertise are associated with special kinds of perceptual skills, and teaching presents its own perceptual challenges. We discuss the special nature of the expert looking that teachers must develop and how it relates to more general models of expertise. Standard methods of classroom video are limited in their support of teacher professional looking, and we explore an alternative using mobile eyetracking that overcomes many of these limits. The combination of mobile eyetracking records and standard video enables the participant to “re-experience” a situation in a vivid way, while also seeing things they missed the first time through.MethodsWe report a study in which pairs of novice and experienced teachers teaching the same students watched their own mobile eyetracking recordings while performing a retrospective think-aloud task.ResultsExperienced teachers were better able to describe high-level features and their significance in the lessons, while novices were more likely to talk about in-the-moment events such as things they failed to see while teaching. This is consistent with work on expertise that suggests there are both costs and benefits to expert looking.DiscussionOur results suggest that the ability to quickly grasp the meaning of a classroom situation may be associated with less awareness of some of the lower-level features on which those inferences are based. Novice and experienced teachers notice different things and have different perspectives on classroom processes; understanding the cognitive process of teachers will require combining insights from each. The methods used in this study are quickly becoming less costly and more accessible, and they have a unique role to play in research and in teacher professional development.

Published
2024
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235. Caecal microbiota in horses with trigeminal-mediated headshaking.

Author

Aleman, Monica, Sheldon, Shara A, Jospin, Guillaume, Coil, David, Stratton-Phelps, Meri, and Eisen, Jonathan

Subjects
Cecum, Animals, Horses, Horse Diseases, Diet, Seasons, Microbiota, headshaking, microbiome, neuropathic, pain, trigeminal, Aetiology, 2.1 Biological and endogenous factors
Abstract

BackgroundTrigeminal-mediated headshaking (TMHS) in horses is a form of neuropathic pain of undetermined cause that often results in euthanasia. The role of microbiota in TMHS has not been investigated in diseased horses.ObjectiveTo investigate if gastrointestinal microbiota in the cecum is different in horses with TMHS compared to a control population, during a summer season with clinical manifestations of disease.AnimalsTen castrated horses: five with TMHS and five neurologically normal controls.MethodsAll horses were sourced from our institution and kept under the same husbandry and dietary conditions. All horses were fed orchard grass hay for 30 days and then were euthanized due to chronic untreatable conditions including TMHS and orthopedic disease (control group). Caecal samples for microbiota analysis were collected within 20 min after euthanasia. Sequencing was performed using an Illumina MiSeq platform and the microbiome was analyzed.ResultsThe caecal microbiota of horses with TMHS was similar to control horses in terms of diversity but differed significantly with Methanocorpusculum spp. having higher abundance in horses with TMHS.  CONCLUSIONS AND CLINICAL IMPORTANCE: Methanocorpusculum spp. was more abundant in the cecum of horses with TMHS. However, its role in disease is unknown. Furthermore, it could also represent an incidental finding due to our small population size.

Published
2022

240. First-time measurement of Timelike Compton Scattering

Author

Chatagnon, P., Niccolai, S., Stepanyan, S., Amaryan, M. J., Angelini, G., Armstrong, W. R., Atac, H., Gayoso, C. Ayerbe, Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benmokhtar, F., Bianconi, A., Biondo, L., Biselli, A. S., Bondi, M., Bossù, F., Boiarinov, S., Briscoe, W. J., Brooks, W. K., Bulumulla, D., Burkert, V. D., Carman, D. S., Carvajal, J. C., Caudron, M., Celentano, A., Chetry, T., Ciullo, G., Clark, L., Cole, P. L., Contalbrigo, M., Costantini, G., Crede, V., D'Angelo, A., Dashyan, N., Defurne, M., De Vita, R., Deur, A., Diehl, S., Djalali, C., Dupré, R., Egiyan, H., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Fegan, S., Fersch, R., Filippi, A., Gavalian, G., Ghandilyan, Y., Gilfoyle, G. P., Girod, F. X., Glazier, D. I., Golubenko, A. A., Gothe, R. W., Gotra, Y., Griffioen, K. A., Guidal, M., Guo, L., Hakobyan, H., Hattawy, M., Hayward, T. B., Heddle, D., Hobart, A., Holtrop, M., Hyde, C. E., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jo, H. S., Joo, K., Kabir, M. L., Keller, D., Khachatryan, G., Khanal, A., Kim, A., Kim, W., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lanza, L., Leali, M., Lee, S., Lenisa, P., Livingston, K., MacGregor, I . J . D., Marchand, D., Marsicano, L., Mascagna, V., McKinnon, B., McLauchlin, C., Migliorati, S., Mirazita, M., Mokeev, V., Montgomery, R. A., Camacho, C. Munoz, Nadel-Turonski, P., Naidoo, P., Neupane, K., O'Connell, T. R., Osipenko, M., Ouillon, M., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Phelps, W., Pogorelko, O., Poudel, J., Price, J. W., Prok, Y., Raue, B. A., Reed, T., Ripani, M., Rizzo, A., Rossi, P., Rowley, J., Sabatié, F., Schmidt, A., Segarra, E. P., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Sokhan, D., Soto, O., Sparveris, N., Strakovsky, I. I., Strauch, S., Tyler, N., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Voskanyan, H., Vossen, A., Voutier, E., Watts, D. P., Wei, K., Wei, X., Wishart, R., Yale, B., Zachariou, N., Zhang, J., Zhao, Z. W., and Collaboration, the CLAS

Subjects
High Energy Physics - Experiment
Abstract

We present the first measurement of the Timelike Compton Scattering process, $\gamma p\to p^\prime \gamma^* (\gamma^*\to e^+e^-) $, obtained with the CLAS12 detector at Jefferson Lab. The photon beam polarization and the decay lepton angular asymmetries are reported in the range of timelike photon virtualities $2.25

Published
2021
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241. Spectra of three-peg Hanoi towers graphs

Author

Hungar, Brett, Mograby, Gamal, Phelps, Madison, Rogers, Luke G., and Wheeler, Jonathan

Subjects
Mathematics - Combinatorics, 05C50 (Primary) 05C25, 20E80, 28A80 (Secondary)
Abstract

We consider the relationship between the Laplacians on two sequences of planar graphs, one from the theory of self-similar groups and one from analysis on fractals. By establishing a spectral decimation map between these sequences we give an elementary calculation of the spectrum of the former, which was first computed by Grigorchuk and \v{S}uni\'{c}. Our method also gives a full description of the eigenfunctions., Comment: 22 pages, 9 figures

Published
2021

242. Human-AI Interactions Through A Gricean Lens

Author

Panfili, Laura, Duman, Steve, Nave, Andrew, Ridgeway, Katherine Phelps, Eversole, Nathan, and Sarikaya, Ruhi

Subjects
Computer Science - Human-Computer Interaction
Abstract

Grice's Cooperative Principle (1975) describes the implicit maxims that guide conversation between humans. As humans begin to interact with non-human dialogue systems more frequently and in a broader scope, an important question emerges: what principles govern those interactions? The present study addresses this question by evaluating human-AI interactions using Grice's four maxims; we demonstrate that humans do, indeed, apply these maxims to interactions with AI, even making explicit references to the AI's performance through a Gricean lens. Twenty-three participants interacted with an American English-speaking Alexa and rated and discussed their experience with an in-lab researcher. Researchers then reviewed each exchange, identifying those that might relate to Grice's maxims: Quantity, Quality, Manner, and Relevance. Many instances of explicit user frustration stemmed from violations of Grice's maxims. Quantity violations were noted for too little but not too much information, while Quality violations were rare, indicating trust in Alexa's responses. Manner violations focused on speed and humanness. Relevance violations were the most frequent, and they appear to be the most frustrating. While the maxims help describe many of the issues participants encountered, other issues do not fit neatly into Grice's framework. Participants were particularly averse to Alexa initiating exchanges or making unsolicited suggestions. To address this gap, we propose the addition of human Priority to describe human-AI interaction. Humans and AIs are not conversational equals, and human initiative takes priority. We suggest that the application of Grice's Cooperative Principles to human-AI interactions is beneficial both from an AI development perspective and as a tool for describing an emerging form of interaction.

Published
2021
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244. From Knowing to Doing: Assessing the Skills Used to Teach Reading and Writing

Author

Phelps, Geoffrey and Bridgeman, Brent

Abstract

This study presents results from a project to develop and pilot a new type of performance assessment of the skills used when teaching reading and writing. To provide context for this new approach, we begin by identifying the different types of knowledge that have historically been the focus of teacher assessment. Next we describe the newly developed performance assessment and present results from a pilot with 59 teacher candidates. The results suggest that the performance tasks can provide reliable evidence of the skills used to teach a range of reading and writing content across the K-6 grade span. We conclude by discussing the importance of future studies to further evaluate the validity argument for this type of performance assessment. We suggest potential uses such as studying teacher knowledge and learning, evaluating teacher education and professional development, and providing formative feedback as part of teacher preparation.

Published
2022
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245. Ageing influences detrusor contractions to prostaglandin, angiotensin, histamine and 5-HT (serotonin), independent to the Rho kinase and extracellular calcium pathways

Author

Charlotte Phelps, Russ Chess-Williams, and Christian Moro

Subjects
Medicine, Science
Abstract

Abstract Ageing is associated with deteriorating urinary bladder function and an increasing prevalence of disorders such as underactive bladder. There are suggestions that G protein-coupled receptor (GPCR) second messenger pathways are altered during ageing, rather than the receptor proteins themselves. The aim of this study was to identify age-related variations in GPCR activation systems in urinary bladder smooth muscle (detrusor). Isolated porcine detrusor strips were mounted in organ baths and contractile responses induced by receptor agonists were assessed and compared between juvenile (6 months) and adult (2 years) animals. The effects of drugs disrupting intracellular calcium signalling were also studied. Adult tissue was far more sensitive to stimulation by 5-hydroxytryptamine (42% greater increase than juvenile), prostaglandin-E2 (26% greater increase), and angiotensin-II (39% greater increase), however less sensitive to histamine. Although nifedipine and Y-27632 impacted the contraction to all agonists, there were no significant differences between juvenile and adult detrusor. Impairment of IP3-mediated calcium release by 2-aminoethyl diphenylborinate had no effect on any contractile activity, except for neurokinin-A which inhibited both juvenile and adult detrusor, and prostaglandin-E2 which inhibited juvenile. Carbachol, histamine, 5-hydroxytryptamine, and angiotensin-II were not affected by the application of 2-aminoethyl diphenylborinate. In conclusion, the contractile responses to all the GPCR agonists involved extracellular calcium influx and calcium sensitisation, but for prostaglandin-E2 the dependence on calcium from intracellular sources was greater in the younger animals.

Published
2023
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246. De novo assembly and annotation of the singing mouse genome

Author

Samantha K. Smith, Paul W. Frazel, Alireza Khodadadi-Jamayran, Paul Zappile, Christian Marier, Mariam Okhovat, Stuart Brown, Michael A. Long, Adriana Heguy, and Steven M. Phelps

Subjects
Genome, Rodents, Vocal communication, Social cognition, Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background Developing genomic resources for a diverse range of species is an important step towards understanding the mechanisms underlying complex traits. Specifically, organisms that exhibit unique and accessible phenotypes-of-interest allow researchers to address questions that may be ill-suited to traditional model organisms. We sequenced the genome and transcriptome of Alston’s singing mouse (Scotinomys teguina), an emerging model for social cognition and vocal communication. In addition to producing advertisement songs used for mate attraction and male-male competition, these rodents are diurnal, live at high-altitudes, and are obligate insectivores, providing opportunities to explore diverse physiological, ecological, and evolutionary questions. Results Using PromethION, Illumina, and PacBio sequencing, we produced an annotated genome and transcriptome, which were validated using gene expression and functional enrichment analyses. To assess the usefulness of our assemblies, we performed single nuclei sequencing on cells of the orofacial motor cortex, a brain region implicated in song coordination, identifying 12 cell types. Conclusions These resources will provide the opportunity to identify the molecular basis of complex traits in singing mice as well as to contribute data that can be used for large-scale comparative analyses.

Published
2023
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247. Pharmacokinetics and tolerability of multiple‐day oral dosing of mycophenolate mofetil in healthy horses

Author

Kaitlyn Bello, Gwendolen Lorch, Kyeongmin Kim, Ramiro E. Toribio, Liwei Yan, Zhiliang Xie, Kasey Hill, and Mitch Phelps

Subjects
dermatology, equine, immune‐mediated, lymphopenia, neutropenia, Veterinary medicine, SF600-1100
Abstract

Abstract Background Additional efficacious immunomodulatory treatment is needed for the management of immune‐mediated disease in horses. Mycophenolate mofetil (MMF) is an immunosuppressive drug that warrants assessment as a viable therapeutic agent for horses. Hypothesis/Objectives To evaluate the pharmacokinetics (PK) of multiple‐day oral dosing of MMF in healthy horses and to determine the tolerability of this dosing regimen. Animals Six healthy Standardbred mares. Methods Horses received MMF 10 mg/kg PO q12h for 7 days in the fed state. Serial sampling was performed over 12 hours on Days 1 and 7 with trough samples collected every 24 hours, immediately before morning drug administration. Noncompartmental PK analyses were performed to determine primary PK parameters, followed by calculation of geometric means and coefficients of variation. A CBC, serum biochemical profile, physical examination, and fecal scoring were used to assess dose tolerability. Results Seven days of treatment resulted in a mycophenolic acid (MPA) area under the curve (AUC0‐12) of 12 594 h × ng/mL (8567‐19 488 h × ng/mL) and terminal half‐life (T1/2) of 11.3 hours (7.5‐15.9 hours), yielding minor metabolite accumulation in all horses treated. Salmonellosis was detected in the feces of 2 horses by Day 7, and all horses developed myelosuppression, hyperbilirubinemia, hyporexia, decreased gastrointestinal motility, and decreased fecal output by the seventh day of treatment. Conclusion and Clinical Importance Administration of MMF at 10 mg/kg PO q12h resulted in hematologic and clinical toxicity within 1 week of treatment. A decreased MMF dose, frequency, or both is needed to avoid colic. Drug monitoring should include frequent hemograms, serum biochemical profiles, and strict biosecurity protocols.

Published
2023
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249. Plastic pollution on the world’s coral reefs

Author

Pinheiro, Hudson T., MacDonald, Chancey, Santos, Robson G., Ali, Ramadhoine, Bobat, Ayesha, Cresswell, Benjamin J., Francini-Filho, Ronaldo, Freitas, Rui, Galbraith, Gemma F., Musembi, Peter, Phelps, Tyler A., Quimbayo, Juan P., Quiros, T. E. Angela L., Shepherd, Bart, Stefanoudis, Paris V., Talma, Sheena, Teixeira, João B., Woodall, Lucy C., and Rocha, Luiz A.

Published
2023
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