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201. Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study

Author: Jakszyn, P. Bingham, S. Pera, G. Agudo, A. Luben, R. Welch, A. Boeing, H. del Giudice, G. Palli, D. Saieva, C. Krogh, V. Sacerdote, C. Tumino, R. Panico, S. Berglund, G. Simán, H. Hallmans, G. Sanchez, M.J. Larrañaga, N. Barricarte, A. Chirlaque, M.D. Quirós, J.R. Key, T.J. Allen, N. Lund, E. Carneiro, F. Linseisen, J. Nagel, G. Overvad, K. Tjonneland, A. Olsen, A. Bueno-de-Mesquita, H.B. Ocké, M.O. Peeters, P.H.M. Numans, M.E. Clavel-Chapelon, F. Trichopoulou, A. Fenger, C. Stenling, R. Ferrari, P. Jenab, M. Norat, T. Riboli, E. Gonzalez, C.A.
Abstract: The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521 457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was
Published: 2006

202. Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)

Author: Jenab, M. Riboli, E. Ferrari, P. Sabate, J. Slimani, N. Norat, T. Friesen, M. Tjønneland, A. Olsen, A. Overvad, K. Boutron-Ruault, M.-C. Clavel-Chapelon, F. Touvier, M. Boeing, H. Schulz, M. Linseisen, J. Nagel, G. Trichopoulou, A. Naska, A. Oikonomou, E. Krogh, V. Panico, S. Masala, G. Sacerdote, C. Tumino, R. Peeters, P.H. Numans, M.E. Bueno-de-Mesquita, H.B. Büchner, F.L. Lund, E. Pera, G. Sanchez, C.N. Sánchez, M.-J. Arriola, L. Barricarte, A. Quirós, J.R. Hallmans, G. Stenling, R. Berglund, Göran Bingham, S. Khaw, K.-T. Key, T. Allen, N. Carneiro, F. Mahlke, U. Giudice, G.D. Palli, D. Kaaks, R. Gonzalez, C.A.
Abstract: Vitamin C is an antioxidant and inhibitor of carcinogenic N-nitroso compound production in the stomach. Higher dietary vitamin C consumption is associated with decreased risk of gastric cancer (GC) in numerous case-control studies, but data from prospective studies are limited, particularly so for blood measures of vitamin C. The objective of this study was to determine the association of plasma and dietary vitamin C levels with the risk of GC in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 European countries. Using a fluorometric method, vitamin C was measured in pre-diagnostic plasma from 215 GC cases (matched controls = 416). Conditional logistic regression models adjusted by body mass index, total energy intake, smoking status/ duration/intensity and Helicobacter pylori infection status were used to estimate relative cancer risks. No association with GC risk was observed for dietary vitamin C, whereas an inverse GC risk was observed in the highest versus lowest quartile of plasma vitamin C [odds ratio (OR) = 0.55, 95% confidence interval (CI) = 0.31-0.97, Ptrend = 0.043], which was maintained after exclusion of cases with ≤2 years follow-up (OR = 0.40, 95% CI = 0.19-0.83, Ptrend = 0.064). The inverse association was more pronounced in subjects consuming higher levels of red and processed meats, a factor that may increase endogenous N-nitroso compound production. The effect of plasma vitamin C was not different by GC anatomical subsite (cardia/non-cardia) or histological subtype (diffuse/intestinal), and there was no significant interaction of effect with H.pylori. The results of this study show, in a prospective setting, an inverse association of GC risk with high levels of plasma vitamin C and suggest an interaction with the intake of red and processed meats, whose consumption may elevate endogenous N-nitroso compound production. © 2006 Oxford University Press.
Published: 2006

203. Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-1 and IGFBP-3 and breast cancer risk: results from the EPIC study

Author: Canzian, F., McKay, J.D., Cleveland, R.J., Dossus, L., Biessy, C., Rinaldi, S., Landi, S., Boillot, C., Monnier, S., Chajes, V., Clavel-Chapelon, F., Tehard, B., Chang-Claude, J., Linseisen, J., Lahmann, P.H., Pischon, T., Trichopoulos, D., Trichopoulou, A., Zilis, D., Palli, D., Tumino, R., Vineis, P., Berrino, F., Bueno de Mesquita, H.B., van Gils, C.H., Peeters, P.H.M., Pera, G., Ardanaz, E., Chirlaque, M.D., Quiros, J.R., Larranaga, N., Martinez-Garcia, C., Allen, N.E., Key, T.J., Bingham, S, Khaw, K.T., Slimani, N., Norat, T., Riboli, E., and Kaaks, R.
Published: 2006

204. Fruits and vegetables and renal cell carcinoma: Findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Weikert, S., Boeing, H., Pischon, T., Anja Viendahl Olsen, Tjønneland, A., Kim Overvad, Becker, N., Linseisen, J., Ph, Lahmann, Arvaniti, A., Kassapa, C., Trichopoulou, A., Sieri, S., Tumino, R., Vineis, P., Panico, S., Ch, Gils, Ph, Peeters, Hb, Bueno-De-Mesquita, Fl, Buchner, Ljungberg, B., Hallmans, G., Berglund, G., Wirfalt, E., Pera, G., Dorronsoro, M., Ab, Gurrea, Navarro, C., Martinez, C., Jr, Quiros, Allen, N., Roddam, A., Bingham, S., Jenab, M., Slimani, N., Norat, T., and Riboli, E.
Published: 2006

205. No association between polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the risk of gastric adenocarcinoma in the European prospective investigation into cancer and nutrition

Author: Agudo, A Sala, N Pera, G Capella, G Berenguer, A and Garcia, N Palli, D Boeing, H Del Giudice, G Saieva, C and Carneiro, F Berrino, F Sacerdote, C Tumino, R and Panico, S Berglund, G Siman, H Stenling, R Hallmans, G and Martinez, C Amiano, P Barricarte, A Navarro, C and Quiros, JR Allen, N Key, T Bingham, S Khaw, KT and Linseisen, J Nagel, G Overvad, K Tjonneland, A Olsen, A and Bueno-De-Mesquita, HB Boshuizen, HC Peeters, PH Numans, ME Clavel-Chapelon, F Boutron-Ruault, MC Trichopoulou, A and Lund, E Blaker, H Jenab, M Ferrari, P Norat, T and Riboli, E Gonzalez, CA
Published: 2006

206. Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Al-Delaimy, WK Ferrari, P Slimani, N Pala, V Johansson, I Nilsson, S Mattisson, I Wirfalt, E Galasso, R and Palli, D Vineis, P Tumino, R Dorronsoro, M Pera, G and Ocke, MC Bueno-de-Mesquita, HB Overvad, K Chirlaque, MAD and Trichopoulou, A Naska, A Tjonneland, A Olsen, A Lund, E and Alsaker, EHR Barricarte, A Kesse, E Boutron-Ruault, MC and Clavel-Chapelon, F Key, TJ Spencer, E Bingham, S and Welch, AA Sanchez-Perez, MJ Nagel, G Linseisen, J and Quiros, JR Peeters, PHM van Gils, CH Boeing, H van Kappel, AL Steghens, JP Riboli, E
Subjects: food and beverages
Abstract: Objective: The aim in this study was to assess the association between individual plasma carotenoid levels (alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, lutein, zeaxanthin) and fruit and vegetable intakes recorded by a calibrated food questionnaire (FQ) and 24- h dietary recall records (24HDR) in nine different European countries with diverse populations and widely varying intakes of plant foods. Design: A stratified random subsample of 3089 men and women from nine countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had provided blood samples and dietary and other lifestyle information between 1992 and 2000, were included. Results: beta-Cryptoxanthin was most strongly correlated with total fruits (FQ r = 0.52, 24HDR r = 0.39), lycopene with tomato and tomato products (FQ r = 0.38, 24HDR r = 0.25), and alpha-carotene with intake of root vegetables (r = 0.39) and of total carrots (r = 0.38) for FQ only. Based on diet measured by FQ and adjusting for possible confounding by body mass index (BMI), age, gender, smoking status, alcohol intake, and energy intake, the strongest predictors of individual plasma carotenoid levels were fruits (R-partial(2) = 17.2%) for beta-cryptoxanthin, total carrots (R-partial(2) = 13.4%) and root vegetables (R-partial(2) = 13.3%) for alpha-carotene, and tomato products (R-partial(2) = 13.8%) for lycopene. For 24HDR, the highest R-partial(2) was for fruits in relation to beta-cryptoxanthin (7.9%). Conclusions: Intakes of specific fruits and vegetables as measured by food questionnaires are good predictors of certain individual plasma carotenoid levels in our multicentre European study. At individual subject levels, FQ measurements of fruits, root vegetables and carrots, and tomato products are, respectively, good predictors of beta-cryptoxanthin, alpha-carotene, and lycopene in plasma.
Published: 2005

207. Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: Results from the European Prospective Investigation into Cancer and Nutrition Study

Author: Canzian, F McKay, JD Cleveland, RJ Dossus, L Biessy, C and Boillot, C Rinaldi, S Llewellyn, M Chajes, V and Clavel-Chapelon, F Tehard, B Chang-Claude, J Linseisen, J and Lahmann, PH Pischon, T Trichopoulos, D Trichopoulou, A and Zilis, D Palli, D Tumino, R Vineis, P Berrino, F and Bueno-de-Mesquita, HB van Gils, CH Peeters, PHM Pera, G and Barricarte, A Chirlaque, MD Quiros, JR Larranaga, N and Martinez-Garcia, C Allen, NE Key, TJ Bingham, SA Khaw, KT Slimani, N Norat, T Riboli, E Kaaks, R
Abstract: Insulin-like growth factor-I (IGF-I) stimulates cell proliferation and can enhance the development of tumors in different organs. Epidemiologic studies have shown that an elevated level of circulating IGF-I is associated to increased risk of breast cancer as well as other cancers. Genetic variants affecting the release or biological action of growth hormone (GH), the main stimulator of IGF-I production, may predict circulating levels of IGF-I and have an effect on cancer risk. We tested this hypothesis with a large case-control study of 807 breast cancer patients and 1,588 matched control subjects nested within the European Prospective Investigation into Cancer and Nutrition. We genotyped 22 common single nucleotide polymorphisms in 10 genes involved in GH production and action (GHRH, GHRHR, SST, SSTR1-SSTR5, POU1F1, and GH1), and in parallel, we measured serum levels of IGF-I and IGFBP-3, its major binding protein, in samples of cases and controls. SST and SSTR2 polymorphisms showed weak but statistically significant associations with breast cancer risk. SSTR5 polymorphisms were associated with IGF-I levels, whereas one polymorphism in GHRHR and one in POU1F1 were associated with IGFBP-3 levels. Our conclusion is that common genetic variation in the GH synthesis pathway, as measured by single nucleotide polymorphisms selected in the present study, is not a major determinant of IGF-I and IGFBP-3 circulating levels, and it does not play a major role in altering breast cancer risk.
Published: 2005

208. Within- and between-cohort variation in measured macronutrient intakes, taking account of measurement errors, in the European Prospective Investigation into cancer and nutrition study

Author: Ferrari, P Kaaks, R Fahey, MT Slimani, N Day, NE and Pera, G Boshuizen, HC Roddam, A Boeing, H Nagel, G and Thiebaut, A Orfanos, P Krogh, V Braaten, T Riboli, E
Abstract: Multicenter epidemiologic studies provide a unique opportunity to evaluate the association between exposure and disease at the individual and the aggregate levels. The two components can eventually be pooled to corroborate each other, using weights proportional to the intraclass correlation coefficient (ICC), which expresses the amount of between-cohort variability in the exposure variable compared with the total. The greater the ICC, the more the overall estimate will reflect the between-cohort component. Dietary measurements are affected by measurement errors, particularly within a cohort. In 1992-2000, the variability of macronutrient intake distribution before and after calibration for measurement error in the European Prospective Investigation into Cancer and Nutrition was evaluated. A two-level, random-effects model was used. Evaluation of macronutrient densities revealed that energy has a considerable effect on the calibration model, leading to ICC values larger than those for the absolute intakes. Given the shrinkage of the within-center variability, a sizable increase in the ICC was observed for protein in men and women (0.48 and 0.54, respectively) and carbohydrates in men (0.41). Results suggest that the effect of calibration on macronutrient intake variability is greater for the within-cohort component, thus increasing the relative importance of the between-cohort component. After calibration, the two components had a similar weight. This observation has important implications for the analysis of multicenter studies because the between-cohort component provides a large part of the overall heterogeneity.
Published: 2004

209. Body size and breast cancer risk: Findings from the european prospective investigation into cancer and nutrition (EPIC)

Author: Lahmann, PH Hoffmann, K Allen, N Van Gils, CH Khaw, KT and Tehard, B Berrino, F Tjonneland, A Bigaard, J Olsen, A Overvad, K Clavel-Chapelon, F Nagel, G Boeing, H and Trichopoulos, D Economou, G Bellos, G Palli, D Tumino, R and Panico, S Amiano, P Pera, G Quiros, JR Martinez, C and Tormo, MJ Wirfalt, E Berglund, G Hallmans, G Key, TJ and Reeves, G Bingham, S Norat, T Biessy, C Kaaks, R and Riboli, E
Abstract: The evidence for anthropometric factors influencing breast cancer risk is accumulating, but uncertainties remain concerning the role of fat distribution and potential effect modifiers. We used data from 73,542 premenopausal and 103,344 postmenopausal women from 9 European countries, taking part in the EPIC study. RRs from Cox regression models were calculated, using measured height, weight, BMI and waist and hip circumferences; categorized by cohort wide quintiles; and expressed as continuous variables, adjusted for study center, age and other risk factors. During 4.7 years of follow-up, 1,879 incident invasive breast cancers were identified. In postmenopausal women, current HRT modified the body size-breast cancer association. Among nonusers, weight, BMI and hip circumference were positively associated with breast cancer risk (all P-trend less than or equal to 0.002); obese women (BMI > 30) had a 31% excess risk compared to women with BMI < 25. Among HRT users, body measures were inversely but nonsignificantly associated with breast cancer. Excess breast cancer risk with HRT was particularly evident among lean women. Pooled RRs per height increment of 5 cm were 1.05 (95% CI 1.00-1.16) in premenopausal and 1.10 (95% CI 1.05-1.16) in postmenopausal women. Among premenopausal women, hip circumference was the only other measure significantly related to breast cancer (P-trend = 0.03), after accounting for BMI. In postmenopausal women not taking exogenous hormones, general obesity is a significant predictor of breast cancer, while abdominal fat assessed as waist-hip ratio or waist circumference was not related to excess risk when adjusted for BMI. Among premenopausal women, weight and BMI showed nonsignificant inverse associations with breast cancer. (C) 2004 Wiley-Liss, Inc.
Published: 2004

210. Utility of a Liquid Formulation of Levo-thyroxine in Differentiated Thyroid Cancer Patients

Author: Giusti, M., additional, Mortara, L., additional, Machello, N., additional, Monti, E., additional, Pera, G., additional, and Marenzana, M., additional
Published: 2014
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211. Ankle-brachial index in screening for asymptomatic carotid and intracranial atherosclerosis

Author: Jiménez, M., primary, Dorado, L., additional, Hernández-Pérez, M., additional, Alzamora, M.T., additional, Pera, G., additional, Torán, P., additional, Gomis, M., additional, Pérez de la Ossa, N., additional, Millán, M., additional, Escudero, D., additional, Dávalos, A., additional, Arenillas, J.F., additional, and López-Cancio, E., additional
Published: 2014
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212. Smoking and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Gonzalez, CA Pera, G Agudo, A Pallli, D Krogh, V and Vineis, P Tumino, R Panico, S Berglund, G Siman, H and Nyren, O Agren, A Martinez, C DorronsorO', M Barricarte, A Tornio, MJ Quiros, JR Allen, N Bingham, S Day, N and Miller, A Nagel, G Boeing, H Overvad, K Tjonneland, A Bueno-De-Mesquita, HB Boshuizen, HC Peeters, P Numans, M Clavel-Chapelon, F Helen, I Agapitos, E Lund, E and Fahey, M Saracci, R Kaaks, R Riboli, E
Abstract: Smoking has recently been recognised as causally associated with the development of gastric cancer (GC). However, evidence on the effect by sex, duration and intensity of smoking, anatomic subsite and cessation of smoking is limited. Our objective was to assess the relation between tobacco use and GC incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC). We studied data from 521,468 individuals recruited from 10 European countries taking part in the EPIC study. Participants completed lifestyle questionnaires that included questions on lifetime consumption of tobacco and diet in 1991-1998. Participants were followed until September 2002, and during that period 305 cases of stomach cancer were identified. After exclusions, 274 were eligible for the analysis, using the Cox proportional hazard model. After adjustment for educational level, consumption of fresh fruit, vegetables and preserved meat, alcohol intake and body mass index (BMI), there was a significant association between cigarette smoking and gastric cancer risk: the hazard ratio (HR) for ever smokers was 1.45 (95% confidence interval [CI] = 1.08-1.94). The HR of current cigarette smoking was 1.73 (95% CI = 1.06-2.83) in males and 1.87 (95% CI = 1.12-3.12) in females. Hazard ratios increased with intensity and duration of cigarette smoked. A significant decrease of risk was observed after 10 years of quitting smoking. A preliminary analysis of 121 cases with identified anatomic site showed that current cigarette smokers had a higher HR of GC in the cardia (HR = 4.10) than in the distal part of the stomach (HR = 1.94). In this cohort, 17.6 % (95% CI = 10.5-29.5 %) of GC cases may be attributable to smoking. Findings from this large study support the causal relation between smoking and gastric cancer in this European population. Stomach cancer should be added to the burden of diseases caused by smoking. (C) 2003 Wiley-Liss, Inc.
Published: 2003

213. Smoking and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: González, C.A., Pera, G., Agudo, A., Palli, D., Kroch, V., Vineis, P., Tumino, R., Allen, N., Key, T., Binghan, S., Day, N., Bueno-de-Mesquita, H., Peeters, P., Offerhaus, J., Boing, H., Miller, A., Nagel, G., Overvad, K., Tjønneland, A., Helen.I., Agapitos, E., Barricarte, A., Tormo, M.J., Quiros, J.R., Martinez, C., Dorronsoro, M., Calvel, F., Nyren, O., Agren, A., Berglund, G., Simán, H., Numans, M., Lund, E., and Riboli, E.
Published: 2003

214. Smoking and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition

Author: Gonzalez, C. A., Pera, G., Agudo, A., Palli, D., Krogh, V., Vineis, P., Tumino, R., Panico, S., Berglund, G., Siman, H., Nyren, O., Agren, A., Martinez, C., Dorronsoro, M., Barricarte, A., Tormo, M. J., Quiros, J. R., Allen, N., Bingham, S., Day, N., Miller, A., Nagel, G., Boeing, H., Kim Overvad, Tjønneland, A., Bueno-De-Mesquita, H. B., Boshuizen, H. C., Peeters, P., Numans, M., Clavel-Chapelon, F., Helen, I., Agapitos, E., Lund, E., Fahey, M., Saracci, R., Kaaks, R., and Riboli, E.
Published: 2003

215. Prevalencia del síndrome del quemado y estudio de los factores asociados en los trabajadores de un hospital comarcal

Author: Pera, G. and Serra-Prat, M.
Subjects: Maslach Burnout Inventory, Risk factors, Prevalence, Burnout, Síndrome del quemado, Prevalencia, Stress, Estrés, Factores de riesgo
Abstract: Objetivo: El síndrome del quemado o de burnout es un tipo de estrés laboral que puede tener repercusiones psicosomáticas, conductuales, emocionales, familiares y sociales, y que puede ser motivo de absentismo laboral y de bajo rendimiento en el trabajo. El objetivo de este trabajo es conocer la prevalencia del síndrome del quemado entre los trabajadores de un hospital comarcal, así como conocer las características personales y laborales que se asocian a dicho síndrome. Métodos: Se diseñó un estudio observacional transversal en el que se seleccionó una muestra aleatoria, estratificada por categoría profesional, de 300 trabajadores a los que se les administró el Maslach Burnout Inventory para medir el grado de burnout. Este cuestionario consta de tres subescalas: el cansancio emocional, la despersonalización y la realización personal. Resultados: El 13,9% de los entrevistados presentó un grado elevado de burnout para el cansancio emocional, el 11,1% para la despersonalización y el 6,6% para la realización personal. Ninguno de los entrevistados obtuvo puntuaciones elevadas en las tres escalas a la vez, mientras que un 27% presentó un grado alto de burnout en al menos una de las tres escalas. En el análisis multivariante la categoría profesional y el sexo se asociaron de forma estadísticamente significativa con un alto grado de burnout. Conclusiones: La prevalencia de síndrome del quemado en el hospital de Mataró es relativamente baja y se asocia al género y la categoría profesional. Aim: Burnout syndrome refers to a kind of occupational stress that can have psychosomatic, behavioral, emotional, familial, and social repercussions; it can also cause absenteeism and loss of efficacy at work. The aim of this study was to determine the prevalence of burnout among staff in a district hospital, as well as the personal and working characteristics associated with the syndrome. Methods: A cross-sectional study was designed in which a representative random sample of 300 workers, stratified according to professional group, was given the Maslach Burnout Inventory to measure the degree of burnout. This questionnaire has three subscales: emotional exhaustion (EE), depersonalization (DP) and personal achievement (PA). Results: A high degree of burnout was found for EE in 13.9% of the staff interviewed, in 11.1% for DP and in 6.6% for PA. None of the interviewees had high scores for all three scales while 27% had a high level of burnout in at least one of the scales. In the multivariate analysis, professional category and sex were statistically significantly associated with a high level of burnout. Conclusion: The prevalence of burnout in Mataró Hospital (Spain) is relatively low and depends mainly on sex and professional group.
Published: 2002

216. Epidemiologia dell'eiaculazione precoce o della sindrome della incontinenza eiaculatoria

Author: La Pera, G. and Gentile, Vincenzo
Published: 2000

217. Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST).

Author: Crusius, J B A, Canzian, F, Capellá, G, Peña, A S, Pera, G, Sala, N, Agudo, A, Rico, F, Del Giudice, G, Palli, D, Plebani, M, Boeing, H, Bueno-de-Mesquita, H B, Carneiro, F, Pala, V, Save, V E, Vineis, P, Tumino, R, Panico, S, Berglund, G, Manjer, J, Stenling, Roger, Hallmans, Göran, Martínez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quirós, J R, Allen, N, Key, T J, Binghan, S, Caldas, C, Linseisen, J, Kaaks, R, Overvad, K, Tjønneland, A, Büchner, F C, Peeters, P H M, Numans, M E, Clavel-Chapelon, F, Trichopoulou, A, Lundin, Eva, Jenab, M, Rinaldi, S, Ferrari, P, Riboli, E, González, C A, Crusius, J B A, Canzian, F, Capellá, G, Peña, A S, Pera, G, Sala, N, Agudo, A, Rico, F, Del Giudice, G, Palli, D, Plebani, M, Boeing, H, Bueno-de-Mesquita, H B, Carneiro, F, Pala, V, Save, V E, Vineis, P, Tumino, R, Panico, S, Berglund, G, Manjer, J, Stenling, Roger, Hallmans, Göran, Martínez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quirós, J R, Allen, N, Key, T J, Binghan, S, Caldas, C, Linseisen, J, Kaaks, R, Overvad, K, Tjønneland, A, Büchner, F C, Peeters, P H M, Numans, M E, Clavel-Chapelon, F, Trichopoulou, A, Lundin, Eva, Jenab, M, Rinaldi, S, Ferrari, P, Riboli, E, and González, C A
Published: 2008

218. Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST).

Author: Crusius, J.B., Canzian, F., Capella, G., Pena, A.S., Pera, G., Sala, N., Agudo, A., Rico, F., Giudice, G. Del, Palli, D., Plebani, M., Boeing, H., Bueno-De-Mesquita, H.B., Carneiro, F., Pala, V., Save, V.E., Vineis, P., Tumino, R., Panico, S., Berglund, G., Manjer, J., Stenling, R., Hallmans, G., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C, Quiros, J.R., Allen, N., Key, T.J., Binghan, S., Caldas, C., Linseisen, J., Kaaks, R., Overvad, K., Tjonneland, A., Buchner, F.L., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Trichopoulou, A., Lund, E., Jenab, M., Rinaldi, S., Ferrari, P., Riboli, E., Gonzalez, C.A., Crusius, J.B., Canzian, F., Capella, G., Pena, A.S., Pera, G., Sala, N., Agudo, A., Rico, F., Giudice, G. Del, Palli, D., Plebani, M., Boeing, H., Bueno-De-Mesquita, H.B., Carneiro, F., Pala, V., Save, V.E., Vineis, P., Tumino, R., Panico, S., Berglund, G., Manjer, J., Stenling, R., Hallmans, G., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C, Quiros, J.R., Allen, N., Key, T.J., Binghan, S., Caldas, C., Linseisen, J., Kaaks, R., Overvad, K., Tjonneland, A., Buchner, F.L., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Trichopoulou, A., Lund, E., Jenab, M., Rinaldi, S., Ferrari, P., Riboli, E., and Gonzalez, C.A.
Abstract: Item does not contain fulltext, BACKGROUND: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. PATIENTS AND METHODS: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL)1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin alpha and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. RESULTS: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF -487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). CONCLUSION: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC.
Published: 2008

219. Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Allen, NE, Key, TJ, Dossus, L, Rinaldi, S, Cust, A, Lukanova, A, Peeters, PH, Onland-Moret, NC, Lahmann, PH, Berrino, F, Panico, S, Larranaga, N, Pera, G, Tormo, M-J, Sanchez, M-J, Quiros, JR, Ardanaz, E, Tjonneland, A, Olsen, A, Chang-Claude, J, Linseisen, J, Schulz, M, Boeing, H, Lundin, E, Palli, D, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, M-C, Bingham, S, Khaw, K-T, Bueno-de-Mesquita, HB, Trichopoulou, A, Trichopoulos, D, Naska, A, Tumino, R, Riboli, E, Kaaks, R, Allen, NE, Key, TJ, Dossus, L, Rinaldi, S, Cust, A, Lukanova, A, Peeters, PH, Onland-Moret, NC, Lahmann, PH, Berrino, F, Panico, S, Larranaga, N, Pera, G, Tormo, M-J, Sanchez, M-J, Quiros, JR, Ardanaz, E, Tjonneland, A, Olsen, A, Chang-Claude, J, Linseisen, J, Schulz, M, Boeing, H, Lundin, E, Palli, D, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, M-C, Bingham, S, Khaw, K-T, Bueno-de-Mesquita, HB, Trichopoulou, A, Trichopoulos, D, Naska, A, Tumino, R, Riboli, E, and Kaaks, R
Abstract: Epidemiological data show that reproductive and hormonal factors are involved in the etiology of endometrial cancer, but there is little data on the association with endogenous sex hormone levels. We analyzed the association between prediagnostic serum concentrations of sex steroids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition using a nested case-control design of 247 incident endometrial cancer cases and 481 controls, matched on center, menopausal status, age, variables relating to blood collection, and, for premenopausal women, phase of menstrual cycle. Using conditional regression analysis, endometrial cancer risk among postmenopausal women was positively associated with increasing levels of total testosterone, free testosterone, estrone, total estradiol, and free estradiol. The odds ratios (ORs) for the highest versus lowest tertile were 2.66 (95% confidence interval (CI) 1.50-4.72; P=0.002 for a continuous linear trend) for estrone, 2.07 (95% CI 1.20-3.60; P=0.001) for estradiol, and 1.66 (95% CI 0.98-2.82; P=0.001) for free estradiol. For total and free testosterone, ORs for the highest versus lowest tertile were 1.44 (95% CI 0.88-2.36; P=0.05) and 2.05 (95% CI 1.23-3.42; P=0.005) respectively. Androstenedione and dehydroepiandrosterone sulfate were not associated with risk. Sex hormone-binding globulin was significantly inversely associated with risk (OR for the highest versus lowest tertile was 0.57, 95% CI 0.34-0.95; P=0.004). In premenopausal women, serum sex hormone concentrations were not clearly associated with endometrial cancer risk, but numbers were too small to draw firm conclusions. In conclusion, relatively high blood concentrations of estrogens and free testosterone are associated with an increased endometrial cancer risk in postmenopausal women.
Published: 2008

220. Cereal fiber intake may reduce risk of gastric adenocarcinomas: the EPIC-EURGAST study.

Author: Mendez, M A, Pera, G, Agudo, A, Bueno-de-Mesquita, HB, Palli, D, Boeing, H, Carneiro, F, Berrino, F, Sacerdote, C, Tumino, R, Panico, S, Berglund, G, Manjer, J, Johansson, Ingegerd, Stenling, R, Martinez, C, Dorronsoro, M, Barricarte, A, Tormo, MJ, Quiros, JR, Allen, N, Key, TJ, Bingham, S, Linseisen, J, Kaaks, R, Overvad, K, Jensen, M, Olsen, A, Tjonneland, A, Peeters, PH, Numans, ME, Ocké, MC, Clavel-Chapelon, F, Boutron-Ruault, MC, Trichopoulou, A, Lund, E, Slimani, N, Jenab, M, Ferrari, P, Riboli, E, González, CA, Mendez, M A, Pera, G, Agudo, A, Bueno-de-Mesquita, HB, Palli, D, Boeing, H, Carneiro, F, Berrino, F, Sacerdote, C, Tumino, R, Panico, S, Berglund, G, Manjer, J, Johansson, Ingegerd, Stenling, R, Martinez, C, Dorronsoro, M, Barricarte, A, Tormo, MJ, Quiros, JR, Allen, N, Key, TJ, Bingham, S, Linseisen, J, Kaaks, R, Overvad, K, Jensen, M, Olsen, A, Tjonneland, A, Peeters, PH, Numans, ME, Ocké, MC, Clavel-Chapelon, F, Boutron-Ruault, MC, Trichopoulou, A, Lund, E, Slimani, N, Jenab, M, Ferrari, P, Riboli, E, and González, CA
Abstract: Numerous case-control studies suggest dietary fiber may reduce risk of gastric cancer, but this has not been confirmed prospectively. A previous case-control study reported reduced risk of gastric cardia adenocarcinomas associated with cereal fiber, but not with fruit or vegetable fiber. To date, different food sources of fiber have not been examined with respect to noncardia tumors or diverse histologic sub-types. This study prospectively examines associations between fiber from different food sources and incident gastric adenocarcinomas (GC) among more than 435,000 subjects from 10 countries participating in the European Prospective Investigation into Cancer and Nutrition study. Subjects aged 25-70 years completed dietary questionnaires in 1992-98, and were followed up for a median of 6.7 years. About 312 incident GCs were observed. The relative risk of GC was estimated based on cohort-wide sex-specific fiber intake quartiles using proportional hazards models to estimate hazards ratios (HRs) and 95% confidence intervals (CIs). Intakes of cereal fiber, but not total, fruit or vegetable fiber, were associated with reduced GC risk [adjusted HR for the highest vs. lowest quartile of cereal fiber 0.69, 0.48-0.99]. There was a strong inverse association for diffuse [HR 0.43, 0.22-0.86], but not intestinal type [HR 0.98, 0.54-1.80] tumors. Associations for cardia vs. noncardia tumors were similar to those for overall GC, although cardia associations did not reach significance. Cereal fiber consumption may help to reduce risk of GC, particularly diffuse type tumors. Further study on different food sources of fiber in relation to GC risk is warranted to confirm these relationships.
Published: 2007
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221. Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions.

Author: Manuguerra, M, Matullo, G, Veglia, F, Autrup, H, Dunning, A M, Garte, S, Gormally, E, Malaveille, C, Guarrera, S, Polidoro, S, Saletta, F, Peluso, M, Airoldi, L, Overvad, K, Raaschou-Nielsen, O, Clavel-Chapelon, F, Linseisen, J, Boeing, H, Trichopoulos, D, Kalandidi, A, Palli, D, Krogh, V, Tumino, R, Panico, S, Bueno-De-Mesquita, H B, Peeters, P H, Lund, E, Pera, G, Martinez, C, Amiano, P, Barricarte, A, Tormo, M J, Quiros, J R, Berglund, G, Janzon, L, Jarvholm, B, Day, N E, Allen, N E, Saracci, R, Kaaks, R, Ferrari, P, Riboli, E, Vineis, P, Manuguerra, M, Matullo, G, Veglia, F, Autrup, H, Dunning, A M, Garte, S, Gormally, E, Malaveille, C, Guarrera, S, Polidoro, S, Saletta, F, Peluso, M, Airoldi, L, Overvad, K, Raaschou-Nielsen, O, Clavel-Chapelon, F, Linseisen, J, Boeing, H, Trichopoulos, D, Kalandidi, A, Palli, D, Krogh, V, Tumino, R, Panico, S, Bueno-De-Mesquita, H B, Peeters, P H, Lund, E, Pera, G, Martinez, C, Amiano, P, Barricarte, A, Tormo, M J, Quiros, J R, Berglund, G, Janzon, L, Jarvholm, B, Day, N E, Allen, N E, Saracci, R, Kaaks, R, Ferrari, P, Riboli, E, and Vineis, P
Abstract: It is becoming increasingly evident that single-locus effects cannot explain complex multifactorial human diseases like cancer. We applied the multi-factor dimensionality reduction (MDR) method to a large cohort study on gene-environment and gene-gene interactions. The study (case-control nested in the EPIC cohort) was established to investigate molecular changes and genetic susceptibility in relation to air pollution and environmental tobacco smoke (ETS) in non-smokers. We have analyzed 757 controls and 409 cases with bladder cancer (n=124), lung cancer (n=116) and myeloid leukemia (n=169). Thirty-six gene variants (DNA repair and metabolic genes) and three environmental exposure variables (measures of air pollution and ETS at home and at work) were analyzed. Interactions were assessed by prediction error percentage and cross-validation consistency (CVC) frequency. For lung cancer, the best model was given by a significant gene-environment association between the base excision repair (BER) XRCC1-Arg399Gln polymorphism, the double-strand break repair (DSBR) BRCA2-Asn372His polymorphism and the exposure variable 'distance from heavy traffic road', an indirect and robust indicator of air pollution (mean prediction error of 26%, P<0.001, mean CVC of 6.60, P=0.02). For bladder cancer, we found a significant 4-loci association between the BER APE1-Asp148Glu polymorphism, the DSBR RAD52-3'-untranslated region (3'-UTR) polymorphism and the metabolic gene polymorphisms COMT-Val158Met and MTHFR-677C>T (mean prediction error of 22%, P<0.001, mean CVC consistency of 7.40, P<0.037). For leukemia, a 3-loci model including RAD52-2259C>T, MnSOD-Ala9Val and CYP1A1-Ile462Val had a minimum prediction error of 31% (P<0.001) and a maximum CVC of 4.40 (P=0.086). The MDR method seems promising, because it provides a limited number of statistically stable interactions; however, the biological interpretation remains to be understood.
Published: 2007
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222. CagA+ Helicobacter pylori infection and gastric cancer risk in the EPIC-EURGAST study.

Author: Palli, D., Masala, G., Giudice, G. Del, Plebani, M., Basso, D., Berti, D., Numans, M.E., Ceroti, M., Peeters, P.H., Bueno de Mesquita, H.B., Buchner, F.L., Clavel-Chapelon, F., Boutron-Ruault, M.C., Krogh, V., Saieva, C., Vineis, P., Panico, S., Tumino, R., Nyren, O., Siman, H., Berglund, G., Hallmans, G., Sanchez, M.J., Larrañaga, N., Barricarte, A., Navarro, C, Quiros, J.R., Key, T., Allen, N., Bingham, S., Khaw, K.T., Boeing, H., Weikert, C., Linseisen, J., Nagel, G., Overvad, K., Thomsen, R.W., Tjonneland, A., Olsen, A., Trichoupoulou, A., Trichopoulos, D., Arvaniti, A., Pera, G., Kaaks, R., Jenab, M., Ferrari, P., Nesi, G., Carneiro, F., Riboli, E., Gonzalez, C.A., Palli, D., Masala, G., Giudice, G. Del, Plebani, M., Basso, D., Berti, D., Numans, M.E., Ceroti, M., Peeters, P.H., Bueno de Mesquita, H.B., Buchner, F.L., Clavel-Chapelon, F., Boutron-Ruault, M.C., Krogh, V., Saieva, C., Vineis, P., Panico, S., Tumino, R., Nyren, O., Siman, H., Berglund, G., Hallmans, G., Sanchez, M.J., Larrañaga, N., Barricarte, A., Navarro, C, Quiros, J.R., Key, T., Allen, N., Bingham, S., Khaw, K.T., Boeing, H., Weikert, C., Linseisen, J., Nagel, G., Overvad, K., Thomsen, R.W., Tjonneland, A., Olsen, A., Trichoupoulou, A., Trichopoulos, D., Arvaniti, A., Pera, G., Kaaks, R., Jenab, M., Ferrari, P., Nesi, G., Carneiro, F., Riboli, E., and Gonzalez, C.A.
Abstract: Contains fulltext : 52946.pdf (publisher's version ) (Closed access), Helicobacter pylori (H. pylori), atrophic gastritis, dietary and life-style factors have been associated with gastric cancer (GC). These factors have been evaluated in a large case-control study nested in the European Prospective Investigation into Cancer and Nutrition carried out in 9 countries, including the Mediterranean area. Participants, enrolled in 1992-1998, provided life-style and dietary information and a blood sample (360,000; mean follow-up: 6.1 years). For 233 GC cases diagnosed after enrolment and their 910 controls individually-matched by center, gender, age and blood donation date H. pylori antibodies (antilysate and antiCagA) and plasma Pepsinogen A (PGA) were measured by ELISA methods. Severe chronic atrophic gastritis (SCAG) was defined as PGA circulating levels <22 microg/l. Overall, in a conditional logistic regression analysis adjusted for education, smoke, weight and consumption of total vegetables, fruit, red and preserved meat, H. pylori seropositivity was associated with GC risk. Subjects showing only antibodies anti-H. pylori lysate, however, were not at increased risk, while those with antiCagA antibodies had a 3.4-fold increased risk. Overall, the odds ratio associated with SCAG was 3.3 (95% CI 2.2-5.2). According to site, the risk of noncardia GC associated with CagA seropositivity showed a further increase (OR 6.5; 95% CI 3.3-12.6); on the other hand, a ten-fold increased risk of cardia GC was associated with SCAG (OR 11.0; 95% CI 3.0-40.9). These results support the causal relationship between H. pylori CagA+ strains infection, and GC in these European populations even after taking into account dietary habits. This association was limited to distal GC, while serologically defined SCAG was strongly associated with cardia GC, thus suggesting a divergent risk pattern for these 2 sites.
Published: 2007

223. The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition.

Author: Vollset, S.E., Igland, J., Jenab, M., Fredriksen, A., Meyer, K., Eussen, S., Gjessing, H.K., Ueland, P.M., Pera, G., Sala, N., Agudo, A., Capella, G., Giudice, G. Del, Palli, D., Boeing, H., Weikert, C., Bueno-De-Mesquita, H.B., Carneiro, F., Pala, V., Vineis, P., Tumino, R., Panico, S., Berglund, G., Manjer, J., Stenling, R., Hallmans, G., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C, Quiros, J.R., Allen, N., Key, T.J., Bingham, S., Linseisen, J., Kaaks, R., Overvad, K., Tjonneland, A., Buchner, F.L., Peeters, P.H., Numans, M.E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Trichopoulou, A., Lund, E., Slimani, N., Ferrari, P., Riboli, E., Gonzalez, C.A., Vollset, S.E., Igland, J., Jenab, M., Fredriksen, A., Meyer, K., Eussen, S., Gjessing, H.K., Ueland, P.M., Pera, G., Sala, N., Agudo, A., Capella, G., Giudice, G. Del, Palli, D., Boeing, H., Weikert, C., Bueno-De-Mesquita, H.B., Carneiro, F., Pala, V., Vineis, P., Tumino, R., Panico, S., Berglund, G., Manjer, J., Stenling, R., Hallmans, G., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C, Quiros, J.R., Allen, N., Key, T.J., Bingham, S., Linseisen, J., Kaaks, R., Overvad, K., Tjonneland, A., Buchner, F.L., Peeters, P.H., Numans, M.E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Trichopoulou, A., Lund, E., Slimani, N., Ferrari, P., Riboli, E., and Gonzalez, C.A.
Abstract: Contains fulltext : 53653.pdf (publisher's version ) (Closed access), Previous studies have shown inconsistent associations of folate intake and polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene with gastric cancer risk. Our nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort is the first prospective study of blood folate levels and gastric cancer. Gastric cancer cases (n=247) and controls (n=631) were matched for study center, age, sex, and time of blood donation. Two common single nucleotide polymorphisms of the MTHFR gene were determined, as were plasma concentrations of folate, cobalamin (vitamin B12), total homocysteine, and methylmalonic acid (cobalamin deficiency marker) in prediagnostic plasma. Risk measures were calculated with conditional logistic regression. Although no relations were observed between plasma folate or total homocysteine concentrations and gastric cancer, we observed a trend toward lower risk of gastric cancer with increasing cobalamin concentrations (odds ratio, 0.79 per SD increase in cobalamin; P=0.01). Further analyses showed that the inverse association between cobalamin and gastric cancer was confined to cancer cases with low pepsinogen A levels (marker of severe chronic atrophic gastritis) at the time of blood sampling. The 677 C-->T MTHFR polymorphism was not associated with gastric cancer, but we observed an increased risk with the variant genotype of the 1298 A-->C polymorphism (odds ratio, 1.47 for CC versus AA; P=0.04). In conclusion, we found no evidence of a role of folate in gastric cancer etiology. However, we observed increased gastric cancer risk at low cobalamin levels that was most likely due to compromised cobalamin status in atrophic gastritis preceding gastric cancer.
Published: 2007

224. La riabilitazione del piano perineale come terapia dell'eiaculazione precoce

Author: La Pera, G., Lucera, R., di Palma, P., Gentile, Vincenzo, and Prigiotti, O.
Published: 1997

225. Plasma and Dietary Vitamin C Levels and risk of Gastric Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).

Author: Jenab, M., Riboli, E., Ferrari, P., Sabate, J., Slimani, N., Norat, T., Friesen, M., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.C., Clavel-Chapelon, F., Touvier, M., Boeing, H., Schulz, M., Linseisen, J., Nagel, G., Trichopoulou, A., Naska, A., Oikonomou, E., Krogh, V., Panico, S., Masala, G., Sacerdote, C., Tumino, R., Peeters, P.H., Numans, M.E., Bueno-de-Mesquita, H.B., Büchner, F.L., Lund, E., Pera, G., Sanchez, C.N., Sánchez, M-J., Arriola, L., Barricarte, A., Quirós, J.R., Hallmans, G., Stenling, R., Berglund, G., Bingham, S., Khaw, K-T., Key, T., Allen, N., Carneiro, F., Mahlke, U., Giudice, G. del, Palli, D., Kaaks, R., Gonzalez, C.A., Jenab, M., Riboli, E., Ferrari, P., Sabate, J., Slimani, N., Norat, T., Friesen, M., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.C., Clavel-Chapelon, F., Touvier, M., Boeing, H., Schulz, M., Linseisen, J., Nagel, G., Trichopoulou, A., Naska, A., Oikonomou, E., Krogh, V., Panico, S., Masala, G., Sacerdote, C., Tumino, R., Peeters, P.H., Numans, M.E., Bueno-de-Mesquita, H.B., Büchner, F.L., Lund, E., Pera, G., Sanchez, C.N., Sánchez, M-J., Arriola, L., Barricarte, A., Quirós, J.R., Hallmans, G., Stenling, R., Berglund, G., Bingham, S., Khaw, K-T., Key, T., Allen, N., Carneiro, F., Mahlke, U., Giudice, G. del, Palli, D., Kaaks, R., and Gonzalez, C.A.
Published: 2006

226. Plasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European prospective investigation into cancer and nutrition

Author: Jenab, M, Riboli, E, Ferrari, P, Friesen, M, Sabate, J, Norat, T, Slimani, N, Tjonneland, A, Olsen, A, Overvad, K, Boutron-Ruault, MC, Clavel-Chapelon, F, Boeing, H, Schulz, M, Linseisen, J, Nagel, G, Trichopoulou, A, Naska, A, Oikonomou, E, Berrino, F, Panico, S, Palli, D, Sacerdote, C, Tumino, R, Peeters, PH, Numans, ME, Bueno-de Mesquita, HB, Buchner, FL, Lund, E, Pera, G, Chirlaque, MD, Sanchez, MJ, Arriola, L, Barricarte, A, Quiros, JR, Johansson, Ingegerd, Johansson, Anders, Berglund, G, Bingham, S, Khaw, KT, Allen, N, Key, T, Carneiro, F, Save, V, Del Giudice, G, Plebani, M, Kaaks, R, Gonzalez, CA, Jenab, M, Riboli, E, Ferrari, P, Friesen, M, Sabate, J, Norat, T, Slimani, N, Tjonneland, A, Olsen, A, Overvad, K, Boutron-Ruault, MC, Clavel-Chapelon, F, Boeing, H, Schulz, M, Linseisen, J, Nagel, G, Trichopoulou, A, Naska, A, Oikonomou, E, Berrino, F, Panico, S, Palli, D, Sacerdote, C, Tumino, R, Peeters, PH, Numans, ME, Bueno-de Mesquita, HB, Buchner, FL, Lund, E, Pera, G, Chirlaque, MD, Sanchez, MJ, Arriola, L, Barricarte, A, Quiros, JR, Johansson, Ingegerd, Johansson, Anders, Berglund, G, Bingham, S, Khaw, KT, Allen, N, Key, T, Carneiro, F, Save, V, Del Giudice, G, Plebani, M, Kaaks, R, and Gonzalez, CA
Abstract: Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. Its aetiology may involve dietary antioxidant micronutrients such as carotenoids and tocopherols. The objective of this study was to determine the association of plasma levels of seven common carotenoids, their total plasma concentration, retinol and - and -tocopherol, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 countries. A secondary objective was to determine the association of total sum of carotenoids, retinol and -tocopherol on GCs by anatomical subsite (cardia/noncardia) and histological subtype (diffuse/intestinal). Analytes were measured by high-performance liquid chromatography in prediagnostic plasma from 244 GC cases and 645 controls matched by age, gender, study centre and date of blood donation. Conditional logistic regression models adjusted by body mass index, total energy intake, smoking and Helicobacter pylori infection status were used to estimate relative cancer risks. After an average 3.2 years of follow-up, a negative association with GC risk was observed in the highest vs the lowest quartiles of plasma -cryptoxanthin (odds ratio (OR)=0.53, 95% confidence intervals (CI)=0.30-0.94, Ptrend=0.006), zeaxanthin (OR=0.39, 95% CI=0.22-0.69, Ptrend=0.005), retinol (OR=0.55, 95% CI=0.33-0.93, Ptrend=0.005) and lipid-unadjusted -tocopherol (OR=0.59, 95% CI=0.37-0.94, Ptrend=0.022). For all analytes, no heterogeneity of risk estimates or significant associations were observed by anatomical subsite. In the diffuse histological subtype, an inverse association was observed with the highest vs lowest quartile of lipid-unadjusted -tocopherol (OR=0.26, 95% CI=0.11-0.65, Ptrend=0.003). These results show that higher plasma concentrations of some carotenoids, retinol and -tocopherol are associated with reduced risk of GC.
Published: 2006
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227. Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).

Author: Gonzalez, C.A., Pera, G., Agudo, A., Bueno-De-Mesquita, H.B., Ceroti, M., Boeing, H., Schulz, M., Giudice, G. Del, Plebani, M., Carneiro, F., Berrino, F., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Siman, H., Hallmans, G., Stenling, R., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C, Quiros, J.R., Allen, N., Key, T.J., Bingham, S., Day, N., Linseisen, J., Nagel, G., Overvad, K., Jensen, M.K., Olsen, A., Tjonneland, A., Buchner, F.L., Peeters, P.H., Numans, M.E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Roukos, D., Trichopoulou, A., Psaltopoulou, T., Lund, E., Casagrande, C., Slimani, N., Jenab, M., Riboli, E., Gonzalez, C.A., Pera, G., Agudo, A., Bueno-De-Mesquita, H.B., Ceroti, M., Boeing, H., Schulz, M., Giudice, G. Del, Plebani, M., Carneiro, F., Berrino, F., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Siman, H., Hallmans, G., Stenling, R., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C, Quiros, J.R., Allen, N., Key, T.J., Bingham, S., Day, N., Linseisen, J., Nagel, G., Overvad, K., Jensen, M.K., Olsen, A., Tjonneland, A., Buchner, F.L., Peeters, P.H., Numans, M.E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Roukos, D., Trichopoulou, A., Psaltopoulou, T., Lund, E., Casagrande, C., Slimani, N., Jenab, M., and Riboli, E.
Abstract: Contains fulltext : 49914.pdf (publisher's version ) (Closed access), It is considered that fruit and vegetable (F&V) protect against oesophagus and gastric cancer (GC). However, 2 recent meta-analyses suggest that the strength of association on GC seems to be weaker for vegetables than for fruit and weaker in cohort than in case-control studies. No evidence exists from cohort studies about adenocarcinoma of oesophagus (ACO). In 521,457 men and women participating in the EPIC cohort in 10 European countries, information of diet and lifestyle was collected at baseline. After an average of 6.5 years of follow-up, a total of 330 GC and 65 ACO, confirmed and classified by a panel of pathologists, was used for the analysis. We examined the relation between F&V intake and GC and ACO. A calibration study in a sub-sample was used to control diet measurement errors. In a sub-sample of cases and a random sample of controls, antibodies against Helicobacter pylori (Hp) were measured and interactions with F&V were examined in a nested case-control study. We observed no association with total vegetable intake or specific groups of vegetables and GC risk, except for the intestinal type, where a negative association is possible regarding total vegetable (calibrated HR 0.66; 95% CI 0.35-1.22 per 100 g increase) and onion and garlic intake (calibrated HR 0.70; 95% CI 0.38-1.29 per 10 g increase). No evidence of association between fresh fruit intake and GC risk was observed. We found a negative but non significant association between citrus fruit intake and the cardia site (calibrated HR 0.77; 95% CI 0.47-1.22 per 100 g increase) while no association was observed with the non-cardia site. Regarding ACO, we found a non significant negative association for vegetable intake and for citrus intake (calibrated HRs 0.72; 95% CI 0.32-1.64 and 0.77; 95% CI 0.46-1.28 per 100 and 50 g increase, respectively). It seems that Hp infection does not modify the effect of F&V intake. Our study supports a possible protective role of vegetable intake in the intestinal typ
Published: 2006

228. Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC).

Author: Gonzalez, C.A., Jakszyn, P., Pera, G., Agudo, A., Bingham, S, Palli, D., Ferrari, P., Boeing, H.H., del Giudice, G., Plebani, M., Carneiro, F., Nesi, G., Berrino, F., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Siman, H., Nyren, O., Hallmans, G., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Allen, N., Key, T.J., Day, N.E., Linseisen, J., Nagel, G., Bergmann, M.M., Overvad, K., Jensen, M.K., Tjonneland, A., Olsen, A., Bueno de Mesquita, H.B., Ocke, M.C., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Trichopoulou, A., Psaltopoulou, T., Roukos, D., Lund, E., Hemon, B., Kaaks, R., Norat, T., Riboli, E., Gonzalez, C.A., Jakszyn, P., Pera, G., Agudo, A., Bingham, S, Palli, D., Ferrari, P., Boeing, H.H., del Giudice, G., Plebani, M., Carneiro, F., Nesi, G., Berrino, F., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Siman, H., Nyren, O., Hallmans, G., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Allen, N., Key, T.J., Day, N.E., Linseisen, J., Nagel, G., Bergmann, M.M., Overvad, K., Jensen, M.K., Tjonneland, A., Olsen, A., Bueno de Mesquita, H.B., Ocke, M.C., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Trichopoulou, A., Psaltopoulou, T., Roukos, D., Lund, E., Hemon, B., Kaaks, R., Norat, T., and Riboli, E.
Published: 2006

229. No association between polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the risk of gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition.

Author: Agudo, A., Sala, N., Pera, G., Capella, G., Berenguer, A., Garcia, N., Palli, D., Boeing, H.H., Del Giudice, G., Saieva, C., Carneiro, F., Berrino, F., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Siman, H., Stenling, R., Hallmans, G., Martinez, C., Amiano, P., Barricarte, A., Navarro, C., Quiros, J.R., Allen, N., Key, T.J., Bingham, S, Khaw, K.T., Linseisen, J., Nagel, G., Overvad, K., Tjonneland, A., Olsen, A., Bueno de Mesquita, H.B., Boshuizen, H.C., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Trichopoulou, A., Lund, E., Blaker, H., Jenab, M., Ferrari, P., Norat, T., Riboli, E., Gonzalez, C.A., Agudo, A., Sala, N., Pera, G., Capella, G., Berenguer, A., Garcia, N., Palli, D., Boeing, H.H., Del Giudice, G., Saieva, C., Carneiro, F., Berrino, F., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Siman, H., Stenling, R., Hallmans, G., Martinez, C., Amiano, P., Barricarte, A., Navarro, C., Quiros, J.R., Allen, N., Key, T.J., Bingham, S, Khaw, K.T., Linseisen, J., Nagel, G., Overvad, K., Tjonneland, A., Olsen, A., Bueno de Mesquita, H.B., Boshuizen, H.C., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Trichopoulou, A., Lund, E., Blaker, H., Jenab, M., Ferrari, P., Norat, T., Riboli, E., and Gonzalez, C.A.
Published: 2006

230. Plasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European prospective investigation into cancer and nutrition.

Author: Jenab, M., Riboli, E., Ferrari, P., Friesen, M., Sabate, J., Norat, T., Slimani, N., Tjonneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.C., Clavel-Chapelon, F., Boeing, H., Schulz, M., Linseisen, J., Nagel, G., Trichopoulou, A., Naska, A., Oikonomou, E., Berrino, F., Panico, S., Palli, D., Sacerdote, C., Tumino, R., Peeters, P.H., Numans, M.E., Bueno-De-Mesquita, H.B., Buchner, F.L., Lund, E., Pera, G., Chirlaque, M.D., Sanchez, M.J., Arriola, L., Barricarte, A., Quiros, J.R., Johansson, I., Johansson, A., Berglund, G., Bingham, S., Khaw, K.T., Allen, N., Key, T.J., Carneiro, F., Save, V.E., Giudice, G. Del, Plebani, M., Kaaks, R., Gonzalez, C.A., Jenab, M., Riboli, E., Ferrari, P., Friesen, M., Sabate, J., Norat, T., Slimani, N., Tjonneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.C., Clavel-Chapelon, F., Boeing, H., Schulz, M., Linseisen, J., Nagel, G., Trichopoulou, A., Naska, A., Oikonomou, E., Berrino, F., Panico, S., Palli, D., Sacerdote, C., Tumino, R., Peeters, P.H., Numans, M.E., Bueno-De-Mesquita, H.B., Buchner, F.L., Lund, E., Pera, G., Chirlaque, M.D., Sanchez, M.J., Arriola, L., Barricarte, A., Quiros, J.R., Johansson, I., Johansson, A., Berglund, G., Bingham, S., Khaw, K.T., Allen, N., Key, T.J., Carneiro, F., Save, V.E., Giudice, G. Del, Plebani, M., Kaaks, R., and Gonzalez, C.A.
Abstract: Contains fulltext : 51395.pdf (publisher's version ) (Closed access), Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. Its aetiology may involve dietary antioxidant micronutrients such as carotenoids and tocopherols. The objective of this study was to determine the association of plasma levels of seven common carotenoids, their total plasma concentration, retinol and alpha- and gamma-tocopherol, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 countries. A secondary objective was to determine the association of total sum of carotenoids, retinol and alpha-tocopherol on GCs by anatomical subsite (cardia/noncardia) and histological subtype (diffuse/intestinal). Analytes were measured by high-performance liquid chromatography in prediagnostic plasma from 244 GC cases and 645 controls matched by age, gender, study centre and date of blood donation. Conditional logistic regression models adjusted by body mass index, total energy intake, smoking and Helicobacter pylori infection status were used to estimate relative cancer risks. After an average 3.2 years of follow-up, a negative association with GC risk was observed in the highest vs the lowest quartiles of plasma beta-cryptoxanthin (odds ratio (OR) = 0.53, 95% confidence intervals (CI) = 0.30-0.94, P(trend) = 0.006), zeaxanthin (OR = 0.39, 95% CI = 0.22-0.69, P(trend) = 0.005), retinol (OR = 0.55, 95% CI = 0.33-0.93, P(trend) = 0.005) and lipid-unadjusted alpha-tocopherol (OR = 0.59, 95% CI = 0.37-0.94, P(trend) = 0.022). For all analytes, no heterogeneity of risk estimates or significant associations were observed by anatomical subsite. In the diffuse histological subtype, an inverse association was observed with the highest vs lowest quartile of lipid-unadjusted alpha-tocopherol (OR = 0.26, 95% CI = 0.11-0.65, P(trend) = 0.003). These results show that higher plasma concentrations of some carotenoids, retinol and alp
Published: 2006

231. Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).

Author: JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, General Practice & Nursing Science, Gonzalez, C.A., Pera, G., Agudo, A., Bueno de Mesquita, H.B., Ceroti, M., Boeing, H.H., Schulz, M., Del Guidice, G., Plebani, M., Carneiro, F., Berrino, F., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Siman, H., Hallmans, G., Stenling, R., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Allen, N., Key, T.J., Bingham, S, Day, N.E., Linseisen, J., Nagel, G., Overvad, K., Jensen, M.K., Olsen, A., Tjonneland, A., Buchner, F.L., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Roukos, D., Trichopoulou, A., Psaltopoulou, T., Lund, E., Casagrande, C., Slimani, N., Jenab, M., Riboli, E., JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, General Practice & Nursing Science, Gonzalez, C.A., Pera, G., Agudo, A., Bueno de Mesquita, H.B., Ceroti, M., Boeing, H.H., Schulz, M., Del Guidice, G., Plebani, M., Carneiro, F., Berrino, F., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Siman, H., Hallmans, G., Stenling, R., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Allen, N., Key, T.J., Bingham, S, Day, N.E., Linseisen, J., Nagel, G., Overvad, K., Jensen, M.K., Olsen, A., Tjonneland, A., Buchner, F.L., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Roukos, D., Trichopoulou, A., Psaltopoulou, T., Lund, E., Casagrande, C., Slimani, N., Jenab, M., and Riboli, E.
Published: 2006

232. Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-1 and IGFBP-3 and breast cancer risk: results from the EPIC study.

Author: JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Canzian, F., McKay, J.D., Cleveland, R.J., Dossus, L., Biessy, C., Rinaldi, S., Landi, S., Boillot, C., Monnier, S., Chajes, V., Clavel-Chapelon, F., Tehard, B., Chang-Claude, J., Linseisen, J., Lahmann, P.H., Pischon, T., Trichopoulos, D., Trichopoulou, A., Zilis, D., Palli, D., Tumino, R., Vineis, P., Berrino, F., Bueno de Mesquita, H.B., van Gils, C.H., Peeters, P.H.M., Pera, G., Ardanaz, E., Chirlaque, M.D., Quiros, J.R., Larranaga, N., Martinez-Garcia, C., Allen, N.E., Key, T.J., Bingham, S, Khaw, K.T., Slimani, N., Norat, T., Riboli, E., Kaaks, R., JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Canzian, F., McKay, J.D., Cleveland, R.J., Dossus, L., Biessy, C., Rinaldi, S., Landi, S., Boillot, C., Monnier, S., Chajes, V., Clavel-Chapelon, F., Tehard, B., Chang-Claude, J., Linseisen, J., Lahmann, P.H., Pischon, T., Trichopoulos, D., Trichopoulou, A., Zilis, D., Palli, D., Tumino, R., Vineis, P., Berrino, F., Bueno de Mesquita, H.B., van Gils, C.H., Peeters, P.H.M., Pera, G., Ardanaz, E., Chirlaque, M.D., Quiros, J.R., Larranaga, N., Martinez-Garcia, C., Allen, N.E., Key, T.J., Bingham, S, Khaw, K.T., Slimani, N., Norat, T., Riboli, E., and Kaaks, R.
Published: 2006

233. Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC).

Author: JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, General Practice & Nursing Science, Gonzalez, C.A., Jakszyn, P., Pera, G., Agudo, A., Bingham, S, Palli, D., Ferrari, P., Boeing, H.H., del Giudice, G., Plebani, M., Carneiro, F., Nesi, G., Berrino, F., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Siman, H., Nyren, O., Hallmans, G., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Allen, N., Key, T.J., Day, N.E., Linseisen, J., Nagel, G., Bergmann, M.M., Overvad, K., Jensen, M.K., Tjonneland, A., Olsen, A., Bueno de Mesquita, H.B., Ocke, M.C., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Trichopoulou, A., Psaltopoulou, T., Roukos, D., Lund, E., Hemon, B., Kaaks, R., Norat, T., Riboli, E., JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, General Practice & Nursing Science, Gonzalez, C.A., Jakszyn, P., Pera, G., Agudo, A., Bingham, S, Palli, D., Ferrari, P., Boeing, H.H., del Giudice, G., Plebani, M., Carneiro, F., Nesi, G., Berrino, F., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Siman, H., Nyren, O., Hallmans, G., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Allen, N., Key, T.J., Day, N.E., Linseisen, J., Nagel, G., Bergmann, M.M., Overvad, K., Jensen, M.K., Tjonneland, A., Olsen, A., Bueno de Mesquita, H.B., Ocke, M.C., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Trichopoulou, A., Psaltopoulou, T., Roukos, D., Lund, E., Hemon, B., Kaaks, R., Norat, T., and Riboli, E.
Published: 2006

234. Fruits and vegetables and renal cell carcinoma: Findings from the European prospective investigation into cancer and nutrition (EPIC).

Author: JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Weikert, S., Boeing, H.H., Pischon, T., Olsen, A., Tjonneland, A., Overvad, K., Becker, N., Linseisen, J., Lahmann, P.H., Arvaniti, A., Kassapa, C., Trichopoulou, A., Sieri, S., Palli, D., Tumino, R., Vineis, P., Panico, S., van Gils, C.H., Peeters, P.H.M., Bueno de Mesquita, H.B., Buchner, F.L., Ljungberg, B., Hallmans, G., Berglund, G., Wirfalt, E., Pera, G., Dorronsoro, M., Gurrea, A.B., Navarro, C., Martinez, C., Quiros, J.R., Allen, N., Roddam, A., Bingham, S, Jenab, M., Slimani, N., Norat, T., Riboli, E., JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Weikert, S., Boeing, H.H., Pischon, T., Olsen, A., Tjonneland, A., Overvad, K., Becker, N., Linseisen, J., Lahmann, P.H., Arvaniti, A., Kassapa, C., Trichopoulou, A., Sieri, S., Palli, D., Tumino, R., Vineis, P., Panico, S., van Gils, C.H., Peeters, P.H.M., Bueno de Mesquita, H.B., Buchner, F.L., Ljungberg, B., Hallmans, G., Berglund, G., Wirfalt, E., Pera, G., Dorronsoro, M., Gurrea, A.B., Navarro, C., Martinez, C., Quiros, J.R., Allen, N., Roddam, A., Bingham, S, Jenab, M., Slimani, N., Norat, T., and Riboli, E.
Published: 2006

235. No association between polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the risk of gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition.

Author: JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, General Practice & Nursing Science, Agudo, A., Sala, N., Pera, G., Capella, G., Berenguer, A., Garcia, N., Palli, D., Boeing, H.H., Del Giudice, G., Saieva, C., Carneiro, F., Berrino, F., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Siman, H., Stenling, R., Hallmans, G., Martinez, C., Amiano, P., Barricarte, A., Navarro, C., Quiros, J.R., Allen, N., Key, T.J., Bingham, S, Khaw, K.T., Linseisen, J., Nagel, G., Overvad, K., Tjonneland, A., Olsen, A., Bueno de Mesquita, H.B., Boshuizen, H.C., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Trichopoulou, A., Lund, E., Blaker, H., Jenab, M., Ferrari, P., Norat, T., Riboli, E., Gonzalez, C.A., JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, General Practice & Nursing Science, Agudo, A., Sala, N., Pera, G., Capella, G., Berenguer, A., Garcia, N., Palli, D., Boeing, H.H., Del Giudice, G., Saieva, C., Carneiro, F., Berrino, F., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Siman, H., Stenling, R., Hallmans, G., Martinez, C., Amiano, P., Barricarte, A., Navarro, C., Quiros, J.R., Allen, N., Key, T.J., Bingham, S, Khaw, K.T., Linseisen, J., Nagel, G., Overvad, K., Tjonneland, A., Olsen, A., Bueno de Mesquita, H.B., Boshuizen, H.C., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Trichopoulou, A., Lund, E., Blaker, H., Jenab, M., Ferrari, P., Norat, T., Riboli, E., and Gonzalez, C.A.
Published: 2006

236. Types of fat intake and body mass index in a Mediterranean country.

Author: González CA, Pera G, Quirós JR, Lasheras C, Tormo MJ, Rodriguez M, Navarro C, Martinez C, Dorronsoro M, Chirlaque MD, Beguiristain JM, Barricarte A, Amiano P, Agudo A, González, C A, Pera, G, Quirós, J R, Lasheras, C, Tormo, M J, and Rodriguez, M
Published: 2000
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237. Ultrastructural and immunohistochemical characterization of the tunica albuginea in Peyronie's disease and veno-occlusive dysfunction

Author: Vincenzo Gentile, Modesti, A., La Pera, G., Vasaturo, F., Modica, A., Prigiotti, G., Di Silverio, F., and Scarpa, S.
Subjects: Settore MED/04 - Patologia Generale, Male, Platelet-Derived Growth Factor, Microscopy, Penile Induration, Fibroblasts, Electron, Immunohistochemistry, Extracellular Matrix, Impotence, Vasculogenic, Microscopy, Electron, Receptors, corpus cavernosum, platelet-derived growth factor, Humans, Receptors, Platelet-Derived Growth Factor, Penis, Collagen, Vasculogenic, Impotence
Abstract: The tunica albuginea and corpus cavernosum from patients with Peyronie's disease (PD), patients with veno-occlusive dysfunction (VOD), and those from normal control subjects were studied by transmission electron microscopy and immunohistochemical staining for type I, III, and V collagens, platelet-derived growth factor (PDGF) AA and BB homodimers, and PDGF alpha and beta receptors. Ultrastructural modifications resembling a fibrotic reaction were detected in the two pathological tunica albuginea, but not in those from control subjects. Ultrastructural data demonstrated a general increase in fibrous and amorphous extracellular matrix material in the pathological tunica albuginea. The amorphous material probably represents glycoproteins and proteoglycans. The fibrous material, representing collagen, appears disorganized in the tissue and does not display the typical and homogeneous diameter, size, and spatial arrangement. Large areas of extracellular and intracytoplasmic, partially degraded, fibers are visible. An increased type I/III collagen ratio was detected by immunohistochemistry in the two pathological tunica albuginea. Moreover, a strong expression of type V collagen, correlated to fibroblasts, was revealed. Fibroblasts from control tissues, on the other hand, were totally negative. Finally, PDGF AA and BB were positive in fibroblasts from pathological tunica albuginea but were negative in control tissues. PDGF beta receptor was positive in pathological and normal tissue fibroblasts. Tunica albuginea from PD and VOD show similar ultrastructural and immunohistochemical alterations, whereas the corpus cavemosum shows no visible modifications.
Published: 1996

238. Plasma carotenoids as biomarkers of intake of fruits and vegetables : individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Author: Al-Delaimy, WK, Ferrari, P, Slimani, N, Pala, V, Johansson, Ingegerd, Nilsson, S, Mattisson, I, Wirfalt, E, Galasso, R, Palli, D, Vineis, P, Tumino, R, Dorronsoro, M, Pera, G, Ocké, MC, Bueno-de-Mesquita, HB, Overvad, K, Chirlaque, M, Trichopoulou, A, Naska, A, Tjonneland, A, Olsen, A, Lund, E, Alsaker, EH, Barricarte, A, Kesse, E, Boutron-Ruault, MC, Clavel-Chapelon, F, Key, TJ, Spencer, E, Bingham, S, Welch, AA, Sanchez-Perez, MJ, Nagel, G, Linseisen, J, Quirós, JR, Peeters, PH, van Gils, CH, Boeing, H, van Kappel, AL, Steghens, JP, Riboli, E, Al-Delaimy, WK, Ferrari, P, Slimani, N, Pala, V, Johansson, Ingegerd, Nilsson, S, Mattisson, I, Wirfalt, E, Galasso, R, Palli, D, Vineis, P, Tumino, R, Dorronsoro, M, Pera, G, Ocké, MC, Bueno-de-Mesquita, HB, Overvad, K, Chirlaque, M, Trichopoulou, A, Naska, A, Tjonneland, A, Olsen, A, Lund, E, Alsaker, EH, Barricarte, A, Kesse, E, Boutron-Ruault, MC, Clavel-Chapelon, F, Key, TJ, Spencer, E, Bingham, S, Welch, AA, Sanchez-Perez, MJ, Nagel, G, Linseisen, J, Quirós, JR, Peeters, PH, van Gils, CH, Boeing, H, van Kappel, AL, Steghens, JP, and Riboli, E
Abstract: OBJECTIVE: The aim in this study was to assess the association between individual plasma carotenoid levels (alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, lutein, zeaxanthin) and fruit and vegetable intakes recorded by a calibrated food questionnaire (FQ) and 24-h dietary recall records (24HDR) in nine different European countries with diverse populations and widely varying intakes of plant foods. DESIGN: A stratified random subsample of 3089 men and women from nine countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had provided blood samples and dietary and other lifestyle information between 1992 and 2000, were included. RESULTS: beta-Cryptoxanthin was most strongly correlated with total fruits (FQ r = 0.52, 24HDR r = 0.39), lycopene with tomato and tomato products (FQ r = 0.38, 24HDR r = 0.25), and alpha-carotene with intake of root vegetables (r = 0.39) and of total carrots (r = 0.38) for FQ only. Based on diet measured by FQ and adjusting for possible confounding by body mass index (BMI), age, gender, smoking status, alcohol intake, and energy intake, the strongest predictors of individual plasma carotenoid levels were fruits (R(partial)(2) = 17.2%) for beta-cryptoxanthin, total carrots ((partial)(2) = 13.4%) and root vegetables (R(partial)(2) = 13.3%) for alpha-carotene, and tomato products (R(partial)(2) = 13.8%) for lycopene. For 24HDR, the highest R(partial)(2) was for fruits in relation to beta-cryptoxanthin (7.9%). CONCLUSIONS: Intakes of specific fruits and vegetables as measured by food questionnaires are good predictors of certain individual plasma carotenoid levels in our multicentre European study. At individual subject levels, FQ measurements of fruits, root vegetables and carrots, and tomato products are, respectively, good predictors of beta-cryptoxanthin, alpha-carotene, and lycopene in plasma.
Published: 2005
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239. Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study.

Author: Trichopoulou, A, Orfanos, P, Norat, T, Bueno-de-Mesquita, B, Ocke, MC, Peeters, PH, van der Schouw, YT, Boeing, H, Hoffmann, K, Boffetta, P, Nagel, G, Masala, G, Krogh, V, Panico, S, Tumino, R, Vineis, P, Bamia, C, Naska, A, Benetou, V, Ferrari, P, Slimani, N, Pera, G, Martinez-Garcia, C, Navarro, C, Rodriguez-Barranco, M, Dorronsoro, M, Spencer, EA, Key, TJ, Bingham, S, Khaw, KT, Kesse, E, Clavel-Chapelon, F, Boutron-Ruault, MC, Berglund, G, Wirfalt, E, Hallmans, Göran, Johansson, Ingegerd, Tjonneland, A, Olsen, A, Overvad, K, Hundborg, HH, Riboli, E, Trichopoulos, D, Trichopoulou, A, Orfanos, P, Norat, T, Bueno-de-Mesquita, B, Ocke, MC, Peeters, PH, van der Schouw, YT, Boeing, H, Hoffmann, K, Boffetta, P, Nagel, G, Masala, G, Krogh, V, Panico, S, Tumino, R, Vineis, P, Bamia, C, Naska, A, Benetou, V, Ferrari, P, Slimani, N, Pera, G, Martinez-Garcia, C, Navarro, C, Rodriguez-Barranco, M, Dorronsoro, M, Spencer, EA, Key, TJ, Bingham, S, Khaw, KT, Kesse, E, Clavel-Chapelon, F, Boutron-Ruault, MC, Berglund, G, Wirfalt, E, Hallmans, Göran, Johansson, Ingegerd, Tjonneland, A, Olsen, A, Overvad, K, Hundborg, HH, Riboli, E, and Trichopoulos, D
Abstract: OBJECTIVE: To examine whether adherence to the modified Mediterranean diet, in which unsaturates were substituted for monounsaturates, is associated with longer life expectancy among elderly Europeans. DESIGN: Multicentre, prospective cohort study. SETTING: Nine European countries (Denmark, France, Germany, Greece, Italy, the Netherlands, Spain, Sweden, United Kingdom). PARTICIPANTS: 74,607 men and women, aged 60 or more, without coronary heart disease, stroke, or cancer at enrolment and with complete information about dietary intake and potentially confounding variables. MAIN OUTCOME MEASURES: Extent of adherence to a modified Mediterranean diet using a scoring system on a 10 point scale, and death from any cause by time of occurrence, modelled through Cox regression. RESULTS: An increase in the modified Mediterranean diet score was associated with lower overall mortality, a two unit increment corresponding to a statistically significant reduction of 8% (95% confidence interval 3% to 12%). No statistically significant evidence of heterogeneity was found among countries in the association of the score with overall mortality even though the association was stronger in Greece and Spain. When dietary exposures were calibrated across countries, the reduction in mortality was 7% (1% to 12%). CONCLUSION: The Mediterranean diet, modified so as to apply across Europe, was associated with increased survival among older people.
Published: 2005
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240. Genetic Variation in the Growth Hormone Synthesis Pathway in Relation to Circulating Insulin-Like Growth Factor-I, Insulin-Like Growth Factor Binding Protein-3, and Breast Cancer Risk: Results from the European Prospective Investigation into Cancer and Nutrition Study.

Author: Canzian, F., McKay, J.D., Cleveland, R.J., Dossus, L., Biessy, C., Boillot, C., Rinaldi, S., Llewellyn, M., Chajes, V., Clavel-Chapelon, F., Tehard, B., Chang-Claude, J., Linseisen, J., Lahmann, P.H., Pischon, T., Trichopoulos, D., Trichopoulou, A., Zilis, D., Palli, D., Tumino, R., Vineis, P., Berrino, F., Bueno de Mesquita, H.B., van Gils, C.H., Peeters, P.H.M., Pera, G., Barricarte, A., Chirlaque, M.D., Quiros, J.R., Larrangara, N., Martinez-Garcia, C., Allen, N.E., Key, T.J., Bingham, S, Khaw, K.T., Slimani, N., Norat, T., Riboli, E., Kaaks, R., Canzian, F., McKay, J.D., Cleveland, R.J., Dossus, L., Biessy, C., Boillot, C., Rinaldi, S., Llewellyn, M., Chajes, V., Clavel-Chapelon, F., Tehard, B., Chang-Claude, J., Linseisen, J., Lahmann, P.H., Pischon, T., Trichopoulos, D., Trichopoulou, A., Zilis, D., Palli, D., Tumino, R., Vineis, P., Berrino, F., Bueno de Mesquita, H.B., van Gils, C.H., Peeters, P.H.M., Pera, G., Barricarte, A., Chirlaque, M.D., Quiros, J.R., Larrangara, N., Martinez-Garcia, C., Allen, N.E., Key, T.J., Bingham, S, Khaw, K.T., Slimani, N., Norat, T., Riboli, E., and Kaaks, R.
Published: 2005

241. Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Al-Delaimy, W.K., Ferrari, P., Slimani, N., Pala, V., Johansson, I., Nilsson, S., Mattisson, I., Wirfalt, E., Galasso, R., Palli, D., Vineis, P., Tumino, R., Dorronsoro, M., Pera, G., Ocke, M.C., Bueno de Mesquita, H.B., Overvad, K., Chirlaque, M.D., Trichopoulou, A., Naska, A., Tjonneland, A., Olsen, A., Lund, E., Alsaker, E., Barricarte, A., Kesse, E., Boutron-Ruault, M.C., Clavel-Chapelon, F., Key, T.J., Spencer, E., Bingham, S, Welch, A.A., Sanchez-Perez, M.J., Nagel, G., Linseisen, J., Quiros, J.R., Peeters, P.H.M., van Gils, C.H., Boeing, H.H., Kappel, A.L., Steghens, J.P., Riboli, E., Al-Delaimy, W.K., Ferrari, P., Slimani, N., Pala, V., Johansson, I., Nilsson, S., Mattisson, I., Wirfalt, E., Galasso, R., Palli, D., Vineis, P., Tumino, R., Dorronsoro, M., Pera, G., Ocke, M.C., Bueno de Mesquita, H.B., Overvad, K., Chirlaque, M.D., Trichopoulou, A., Naska, A., Tjonneland, A., Olsen, A., Lund, E., Alsaker, E., Barricarte, A., Kesse, E., Boutron-Ruault, M.C., Clavel-Chapelon, F., Key, T.J., Spencer, E., Bingham, S, Welch, A.A., Sanchez-Perez, M.J., Nagel, G., Linseisen, J., Quiros, J.R., Peeters, P.H.M., van Gils, C.H., Boeing, H.H., Kappel, A.L., Steghens, J.P., and Riboli, E.
Published: 2005

242. Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study.

Author: Trichopoulou, A., Orfanos, P., Norat, T., Bueno de Mesquita, H.B., Ocke, M.C., Peeters, P.H.M., van der Schouw, Y.T., Boeing, H.H., Hoffmann, K., Boffetta, P., Nagel, G., Masala, G., Krogh, V., Panico, S., Tumino, R., Vineis, P., Bamia, C., Naska, A., Benetou, V., Ferrari, P., Slimani, N., Pera, G., Martinez-Garcia, J.F., Navarro, C., Rodriguez-Barranco, M., Dorronsoro, M., Spencer, E.A., Key, T.J., Bingham, S, Khaw, K.T., Kesse, E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Berglund, G., Wirfalt, E., Hallmans, G., Johansson, I., Tjonneland, A., Olsen, A., Overvad, K., Hundborg, H.H., Riboli, E., Trichopoulos, D., Trichopoulou, A., Orfanos, P., Norat, T., Bueno de Mesquita, H.B., Ocke, M.C., Peeters, P.H.M., van der Schouw, Y.T., Boeing, H.H., Hoffmann, K., Boffetta, P., Nagel, G., Masala, G., Krogh, V., Panico, S., Tumino, R., Vineis, P., Bamia, C., Naska, A., Benetou, V., Ferrari, P., Slimani, N., Pera, G., Martinez-Garcia, J.F., Navarro, C., Rodriguez-Barranco, M., Dorronsoro, M., Spencer, E.A., Key, T.J., Bingham, S, Khaw, K.T., Kesse, E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Berglund, G., Wirfalt, E., Hallmans, G., Johansson, I., Tjonneland, A., Olsen, A., Overvad, K., Hundborg, H.H., Riboli, E., and Trichopoulos, D.
Published: 2005

243. Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Al-Delaimy, W.K., Ferrari, P., Slimani, N., Pala, V., Johansson, I., Nilsson, S., Mattisson, I., Wirfalt, E., Galasso, R., Palli, D., Vineis, P., Tumino, R., Dorronsoro, M., Pera, G., Ocke, M.C., Bueno de Mesquita, H.B., Overvad, K., Chirlaque, M.D., Trichopoulou, A., Naska, A., Tjonneland, A., Olsen, A., Lund, E., Alsaker, E., Barricarte, A., Kesse, E., Boutron-Ruault, M.C., Clavel-Chapelon, F., Key, T.J., Spencer, E., Bingham, S, Welch, A.A., Sanchez-Perez, M.J., Nagel, G., Linseisen, J., Quiros, J.R., Peeters, P.H.M., van Gils, C.H., Boeing, H.H., Kappel, A.L., Steghens, J.P., Riboli, E., JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Al-Delaimy, W.K., Ferrari, P., Slimani, N., Pala, V., Johansson, I., Nilsson, S., Mattisson, I., Wirfalt, E., Galasso, R., Palli, D., Vineis, P., Tumino, R., Dorronsoro, M., Pera, G., Ocke, M.C., Bueno de Mesquita, H.B., Overvad, K., Chirlaque, M.D., Trichopoulou, A., Naska, A., Tjonneland, A., Olsen, A., Lund, E., Alsaker, E., Barricarte, A., Kesse, E., Boutron-Ruault, M.C., Clavel-Chapelon, F., Key, T.J., Spencer, E., Bingham, S, Welch, A.A., Sanchez-Perez, M.J., Nagel, G., Linseisen, J., Quiros, J.R., Peeters, P.H.M., van Gils, C.H., Boeing, H.H., Kappel, A.L., Steghens, J.P., and Riboli, E.
Published: 2005

244. Genetic Variation in the Growth Hormone Synthesis Pathway in Relation to Circulating Insulin-Like Growth Factor-I, Insulin-Like Growth Factor Binding Protein-3, and Breast Cancer Risk: Results from the European Prospective Investigation into Cancer and Nutrition Study.

Author: JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Canzian, F., McKay, J.D., Cleveland, R.J., Dossus, L., Biessy, C., Boillot, C., Rinaldi, S., Llewellyn, M., Chajes, V., Clavel-Chapelon, F., Tehard, B., Chang-Claude, J., Linseisen, J., Lahmann, P.H., Pischon, T., Trichopoulos, D., Trichopoulou, A., Zilis, D., Palli, D., Tumino, R., Vineis, P., Berrino, F., Bueno de Mesquita, H.B., van Gils, C.H., Peeters, P.H.M., Pera, G., Barricarte, A., Chirlaque, M.D., Quiros, J.R., Larrangara, N., Martinez-Garcia, C., Allen, N.E., Key, T.J., Bingham, S, Khaw, K.T., Slimani, N., Norat, T., Riboli, E., Kaaks, R., JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Canzian, F., McKay, J.D., Cleveland, R.J., Dossus, L., Biessy, C., Boillot, C., Rinaldi, S., Llewellyn, M., Chajes, V., Clavel-Chapelon, F., Tehard, B., Chang-Claude, J., Linseisen, J., Lahmann, P.H., Pischon, T., Trichopoulos, D., Trichopoulou, A., Zilis, D., Palli, D., Tumino, R., Vineis, P., Berrino, F., Bueno de Mesquita, H.B., van Gils, C.H., Peeters, P.H.M., Pera, G., Barricarte, A., Chirlaque, M.D., Quiros, J.R., Larrangara, N., Martinez-Garcia, C., Allen, N.E., Key, T.J., Bingham, S, Khaw, K.T., Slimani, N., Norat, T., Riboli, E., and Kaaks, R.
Published: 2005

245. Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study.

Author: JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Trichopoulou, A., Orfanos, P., Norat, T., Bueno de Mesquita, H.B., Ocke, M.C., Peeters, P.H.M., van der Schouw, Y.T., Boeing, H.H., Hoffmann, K., Boffetta, P., Nagel, G., Masala, G., Krogh, V., Panico, S., Tumino, R., Vineis, P., Bamia, C., Naska, A., Benetou, V., Ferrari, P., Slimani, N., Pera, G., Martinez-Garcia, J.F., Navarro, C., Rodriguez-Barranco, M., Dorronsoro, M., Spencer, E.A., Key, T.J., Bingham, S, Khaw, K.T., Kesse, E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Berglund, G., Wirfalt, E., Hallmans, G., Johansson, I., Tjonneland, A., Olsen, A., Overvad, K., Hundborg, H.H., Riboli, E., Trichopoulos, D., JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Trichopoulou, A., Orfanos, P., Norat, T., Bueno de Mesquita, H.B., Ocke, M.C., Peeters, P.H.M., van der Schouw, Y.T., Boeing, H.H., Hoffmann, K., Boffetta, P., Nagel, G., Masala, G., Krogh, V., Panico, S., Tumino, R., Vineis, P., Bamia, C., Naska, A., Benetou, V., Ferrari, P., Slimani, N., Pera, G., Martinez-Garcia, J.F., Navarro, C., Rodriguez-Barranco, M., Dorronsoro, M., Spencer, E.A., Key, T.J., Bingham, S, Khaw, K.T., Kesse, E., Clavel-Chapelon, F., Boutron-Ruault, M.C., Berglund, G., Wirfalt, E., Hallmans, G., Johansson, I., Tjonneland, A., Olsen, A., Overvad, K., Hundborg, H.H., Riboli, E., and Trichopoulos, D.
Published: 2005

246. The Barcelona-Asymptomatic Intracranial Atherosclerosis (AsIA) study: Prevalence and risk factors

Author: López-Cancio, E., primary, Dorado, L., additional, Millán, M., additional, Reverté, S., additional, Suñol, A., additional, Massuet, A., additional, Galán, A., additional, Alzamora, M.T., additional, Pera, G., additional, Torán, P., additional, Dávalos, A., additional, and Arenillas, J.F., additional
Published: 2012
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247. Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC).

Author: Lahmann, P.H., Hoffmann, K., Allen, N., van Gils, C.H., Khaw, K.T., Tehard, B., Berrino, F., Tjonneland, A., Bigaard, J., Olsen, A., Overvad, K., Clavel-Chapelon, F., Nagel, G., Boeing, H.H., Trichopoulos, D., Economou, G., Bellos, G., Palli, D., Tumino, R., Panico, S., Sacerdote, C., Krogh, V., Peeters, P.H.M., Bueno de Mesquita, H.B., Lund, E., Ardanaz, E., Amiano, P., Pera, G., Quiros, J.R., Martinez, C., Tormo, M.J., Wirfalt, E., Berglund, G., Hallmans, G., Key, T.J., Reeves, G., Bingham, S, Norat, T., Biessy, C., Kaaks, R., Riboli, E., Lahmann, P.H., Hoffmann, K., Allen, N., van Gils, C.H., Khaw, K.T., Tehard, B., Berrino, F., Tjonneland, A., Bigaard, J., Olsen, A., Overvad, K., Clavel-Chapelon, F., Nagel, G., Boeing, H.H., Trichopoulos, D., Economou, G., Bellos, G., Palli, D., Tumino, R., Panico, S., Sacerdote, C., Krogh, V., Peeters, P.H.M., Bueno de Mesquita, H.B., Lund, E., Ardanaz, E., Amiano, P., Pera, G., Quiros, J.R., Martinez, C., Tormo, M.J., Wirfalt, E., Berglund, G., Hallmans, G., Key, T.J., Reeves, G., Bingham, S, Norat, T., Biessy, C., Kaaks, R., and Riboli, E.
Published: 2004

248. Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC).

Author: JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Lahmann, P.H., Hoffmann, K., Allen, N., van Gils, C.H., Khaw, K.T., Tehard, B., Berrino, F., Tjonneland, A., Bigaard, J., Olsen, A., Overvad, K., Clavel-Chapelon, F., Nagel, G., Boeing, H.H., Trichopoulos, D., Economou, G., Bellos, G., Palli, D., Tumino, R., Panico, S., Sacerdote, C., Krogh, V., Peeters, P.H.M., Bueno de Mesquita, H.B., Lund, E., Ardanaz, E., Amiano, P., Pera, G., Quiros, J.R., Martinez, C., Tormo, M.J., Wirfalt, E., Berglund, G., Hallmans, G., Key, T.J., Reeves, G., Bingham, S, Norat, T., Biessy, C., Kaaks, R., Riboli, E., JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Lahmann, P.H., Hoffmann, K., Allen, N., van Gils, C.H., Khaw, K.T., Tehard, B., Berrino, F., Tjonneland, A., Bigaard, J., Olsen, A., Overvad, K., Clavel-Chapelon, F., Nagel, G., Boeing, H.H., Trichopoulos, D., Economou, G., Bellos, G., Palli, D., Tumino, R., Panico, S., Sacerdote, C., Krogh, V., Peeters, P.H.M., Bueno de Mesquita, H.B., Lund, E., Ardanaz, E., Amiano, P., Pera, G., Quiros, J.R., Martinez, C., Tormo, M.J., Wirfalt, E., Berglund, G., Hallmans, G., Key, T.J., Reeves, G., Bingham, S, Norat, T., Biessy, C., Kaaks, R., and Riboli, E.
Published: 2004

249. Retinoids and Prophylaxis of Superficial Bladder Tumor Recurrences

Author: Di Silverio, F., VON HELAND, Magnus, La Pera, G., De Vico, A., Buscarini, M., and DE BERARDINIS, Ettore
Subjects: Retinoids, Prophylaxis, Bladder cancer
Published: 1994

250. Penile Prosthesis

Author: Gentile, Vincenzo and La Pera, G.
Published: 1994

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