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202. Early experience with laparoscopic lavage for perforated diverticulitis

Author

Swank, Ha1, Mulder, Im, Hoofwijk, Ag, Nienhuijs, Sw, Lange, Jf, Bemelman, Wa, van der Hoeven J, Dutch Diverticular Disease Collaborative Study Group., Blanken-Peeters, C, Crolla, R, Belgers, E, Bosker, R, Boom, M, Swank, D, Steup, W, de Graaf, E, Toorenvliet, B, Pierik, E, Prins, H, Stockmann, H, Tollenaar, R, Coene, P, di Saverio, S, Catena, F, Slooter, G, Consten, E, van Duyn, E, Stassen, L, Gerhards, M, Karsten, T, Cense, H, Scheepers, J, Bruin, S, Eijsbouts, Q, Wiezer, M, Mannaerts, G, van Wagensveld, B, van Geloven, A, Maring, J, van Grevenstein, W, D'Hoore, A, Konsten, J, van der Peet, D, Govaert, M, Engel, A, Kruyt, P., Other departments, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Surgery, and RS: NUTRIM - R2 - Gut-liver homeostasis

Subjects
Adult, Male, medicine.medical_specialty, GENERALIZED PERITONITIS, RESECTION, Operative Time, Perforation (oil well), Therapeutic irrigation, Peritonitis, Aspiration pneumonia, DIAGNOSIS, Preoperative care, DISEASE, Diverticulitis, Colonic, Postoperative Complications, HARTMANNS PROCEDURE, medicine, MANAGEMENT, Humans, Therapeutic Irrigation, Laparoscopy, PERITONEAL-LAVAGE, Aged, PRIMARY ANASTOMOSIS, COLONIC DIVERTICULITIS, medicine.diagnostic_test, business.industry, General surgery, Length of Stay, Middle Aged, Diverticulitis, medicine.disease, Surgery, Treatment Outcome, Intestinal Perforation, Second-Look Surgery, Feasibility Studies, Female, business, Multiple organ dysfunction syndrome
Abstract

Background Laparoscopic lavage has recently emerged as a promising alternative to sigmoid resection in the treatment of perforated diverticulitis. This study examined an early experience with this technique. Methods The files of all patients with complicated diverticulitis were searched in 34 teaching hospitals of the Netherlands. Patients with perforated diverticulitis treated with laparoscopic lavage between 1 January 2008 and 31 December 2010 were included. Results Treatment with laparoscopic lavage was performed in only 38 patients in ten hospitals. Lavage was successful in controlling sepsis in 31 of the 38 included patients, with 32 per cent morbidity (10 of 31 patients) and fast recovery. Overall, 17 of 38 patients developed complications, of whom two had a missed overt sigmoid perforation. Two patients died from multiple organ failure and one from aspiration pneumonia; one other patient died after palliative management of inoperable lung carcinoma. Three patients in whom lavage was successful underwent subsequent sigmoid resection for recurrent diverticulitis. Patients in whom lavage was unsuccessful tended to have more co-morbidities, a higher preoperative C-reactive protein concentration and a higher Mannheim Peritonitis Index. Conclusion Laparoscopic lavage for perforated diverticulitis was feasible in the majority of patients, but identification of an overt sigmoid perforation and patient selection are of critical importance. © 2013 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

Published
2013

203. Prognostic Significance of Bone Marrow Trephine and Peripheral Blood Smears in 55 Patients with Mantle Cell Lymphoma

Author

Stefania Pittaluga, Gregor Verhoef, Johan Nuyts, Annelies Maes, Marc Boogaerts, De Wolf-Peeters C, and A. Criel

Subjects
Adult, Male, Cancer Research, Pathology, medicine.medical_specialty, Lymphocytosis, Leukocyte Count, Bone Marrow, Humans, Medicine, Survival analysis, Aged, Aged, 80 and over, business.industry, Lymphoma, Non-Hodgkin, Mantle zone, Hematology, Middle Aged, Prognosis, medicine.disease, Survival Analysis, Lymphoma, Leukemia, medicine.anatomical_structure, Oncology, Trephine, Female, Mantle cell lymphoma, Bone marrow, medicine.symptom, business
Abstract

Bone marrow trephine and peripheral blood smears taken at diagnosis of 55 cases of well-documented mantle cell lymphomas were reviewed in order to analyse the leukaemic involvement in this non-Hodgkin's lymphoma: its incidence, morphological characteristics and prognostic significance. A median survival of 36 months was found. The median age was 61 and the male to female ratio was 4:1. Morphologically 7 cases presented with a mantle zone pattern, all the others had a diffuse pattern. Involvement of the bone marrow was found in 58% and a trend for prolonged survival in patients with a negative trephine was seen. An absolute lymphocytosis above 10,000 mu l was found at diagnosis in 5 cases (10%) and had a statistically significant impact on survival. An additional 5 cases developed frank leukaemia during the course of the disease and died within 1 to 6 months of this evolution, suggesting that marked lymphocytosis is more a terminal event associated with an extremely poor prognosis than a presenting symptom. Finally we identified an additional parameter with statistically prognostic significance, namely, the presence of atypical cells in the peripheral blood even in the absence of an increased lymphocytosis.

Published
1996
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204. Perivascular Spaces in Eccrine Spiradenoma

Author

De Wolf-Peeters C and van den Oord Jj

Subjects
Hyalin, Pathology, medicine.medical_specialty, Thymoma, T-Lymphocytes, Dermatology, Basement Membrane, Pathology and Forensic Medicine, Diagnosis, Differential, Syringoma, medicine, Humans, Perivascular space, Hyaline, Basement membrane, Adenoma, Sweat Gland, Cysts, business.industry, General Medicine, Anatomy, Glomus Tumor, medicine.disease, Carcinoma, Adenoid Cystic, Fibrosis, Glomus tumor, Sweat Gland Neoplasms, medicine.anatomical_structure, Carcinoma, Basal Cell, Blood Vessels, Histopathology, Collagen, Spiradenoma, business, Glomangioma, Dilatation, Pathologic
Abstract

Perivascular spaces were found to represent a useful histological clue to the diagnosis of eccrine spiradenoma. They were observed in eight of nine eccrine spiradenomas but not in syringomas, nodular basal cell carcinomas, or glomangiomas. Perivascular spaces in spiradenomas consisted of variably sized spaces around one or more central blood vessels, bordered at the periphery by a palisade of tumor cells and lined at both sides by basement membrane collagen type IV. Perivascular spaces contained variable numbers of T lymphocytes in all cases and could undergo fibrosis, cystic dilatation, or hyalinization. In analogy to similar structures in thymomas, we suggest that perivascular spaces in spiradenomas are involved in the traffic of lymphocytes toward the tumor.

Published
1995
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205. Anaplastic lymphoma kinase in human cancer

Author

Barreca, A., Lasorsa, E., Riera, L., Machiorlatti, R., Piva, R., Ponzoni, M., Kwee, I., Bertoni, F., Piccaluga, P.P., Pileri, S.A., Inghirami, G.C.B.A., Chiarle, R., Cuccuru, G., Inghirami, G., Martinoglio, B., Medico, E., Pellegrino, E., Ruberto, M.L., Voena, C., Fornari, A., Novero, D., Chilosi, M., Zamó, A., Facchetti, F., Lonardi, S., De Chiara, A., Fulciniti, F., Doglioni, C., Agnelli, L., Neri, A., Todoerti, K., Pileri, S., Falini, B., Tiacci, E., Van Loo, P., Tousseyn, T., De Wolf-Peeters, C., Geissinger, E., Muller-Hermelink, H.K., Rosenwald, A., Piris, M.A., Maria, E.R., Barreca A, Lasorsa E, Riera L, Machiorlatti R, Piva R, Ponzoni M, Kwee I, Bertoni F, Piccaluga PP, Pileri SA, Inghirami G, and the European T-Cell Lymphoma Study Group, Barreca, A, Lasorsa, E, Riera, L, Machiorlatti, R, Piva, R, Ponzoni, Maurilio, Kwee, I, Bertoni, F, Piccaluga, Pp, Pileri, Sa, and Inghirami, G.

Subjects
Transcriptional Activation, Lymphoma, kinase, Settore MED/06 - Oncologia Medica, Pyridines, Receptor Protein-Tyrosine Kinases, Antineoplastic Agents, Receptor tyrosine kinase, Translocation, Genetic, CSK Tyrosine-Protein Kinase, Proto-Oncogene Proteins p21(ras), Phosphatidylinositol 3-Kinases, Endocrinology, Crizotinib, Piperidines, Neoplasms, Proto-Oncogene Proteins, hemic and lymphatic diseases, medicine, cancer, Anaplastic lymphoma kinase, Humans, Anaplastic Lymphoma Kinase, anaplastic lymphoma, Molecular Biology, Anaplastic large-cell lymphoma, Nucleophosmin, biology, Phospholipase C gamma, ALK, Intracellular Signaling Peptides and Proteins, Protein-Tyrosine Kinases, medicine.disease, BCL10, Up-Regulation, src-Family Kinases, Mutation, Cancer research, biology.protein, Pyrazoles, Signal transduction, medicine.drug, Signal Transduction
Abstract

The receptor tyrosine kinases (RTKs) play a critical role, controlling cell proliferation, survival, and differentiation of normal cells. Their pivotal function has been firmly established in the pathogenesis of many cancers as well. The anaplastic lymphoma kinase (ALK), a transmembrane RTK, originally identified in the nucleophosmin (NPM)–ALK chimera of anaplastic large cell lymphoma, has emerged as a novel tumorigenic player in several human cancers. In this review, we describe the expression of the ALK–RTK, its related fusion proteins, and their molecular mechanisms of activation. Novel tailored strategies are briefly illustrated for the treatment of ALK-positive neoplasms.

Published
2011

206. Restin in Hodgkin's Disease and Anaplastic Large Cell Lymphoma

Author

De Wolf-Peeters C, Josef Brüggen, Jan Delabie, Van Leuven F, and G. Bilbe

Subjects
Cancer Research, Pathology, medicine.medical_specialty, CD30, Biology, Intermediate Filament Proteins, immune system diseases, hemic and lymphatic diseases, medicine, Humans, Anaplastic lymphoma kinase, Neoplastic transformation, Reed-Sternberg Cells, Anaplastic large-cell lymphoma, Chromosomes, Human, Pair 12, Cell growth, Chromosome Mapping, Hematology, medicine.disease, Hodgkin Disease, Neoplasm Proteins, Lymphoma, Cell Transformation, Neoplastic, Oncology, Reed–Sternberg cell, Lymphoma, Large B-Cell, Diffuse, REL, Microtubule-Associated Proteins
Abstract

We recently characterized a novel putative intermediate-filament associated protein which is strongly expressed in the Reed-Sternberg cells of Hodgkin's disease. Therefore we named the protein ‘restin’, an acronym for Reed-Sternberg cell intermediate filament-associated protein. The protein is also expressed in anaplastic large cell lymphoma or Ki-1 lymphoma, a non-Hodgkin's lymphoma phenotypically related to Hodgkin's disease. Although the functions of restin are not yet fully elucidated, transfection experiments demonstrate that over-expression of the protein increases cell growth by a mechanism which may involve upregulation of the transferrin receptor. Hence, restin may contribute to neoplastic transformation in Hodgkin's disease and anaplastic large cell lymphoma. Study of the mechanisms leading to restin overexpression may provide important data on the etiology of Hodgkin's disease and its relation to anaplastic large cell lymphoma.

Published
1993
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208. Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial

Author

Vennix, Sandra, primary, Musters, Gijsbert D, additional, Mulder, Irene M, additional, Swank, Hilko A, additional, Consten, Esther C, additional, Belgers, Eric H, additional, van Geloven, Anna A, additional, Gerhards, Michael F, additional, Govaert, Marc J, additional, van Grevenstein, Wilhelmina M, additional, Hoofwijk, Anton G, additional, Kruyt, Philip M, additional, Nienhuijs, Simon W, additional, Boermeester, Marja A, additional, Vermeulen, Jefrey, additional, van Dieren, Susan, additional, Lange, Johan F, additional, Bemelman, Willem A, additional, Hop, W C, additional, Opmeer, B C, additional, Reitsma, J B, additional, Scholte, R A, additional, Waltmann, E W H, additional, Legemate, D A, additional, Bartelsman, J F, additional, Meijer, D W, additional, de Brouwer, M, additional, van Dalen, J, additional, Durbridge, M, additional, Geerdink, M, additional, Ilbrink, G J, additional, Mehmedovic, S, additional, Middelhoek, P, additional, Di Saverio, Salomone, additional, Boom, M J, additional, Consten, E C J, additional, van der Bilt, J D W, additional, van Olden, G D J, additional, Stam, M A W, additional, Verweij, M S, additional, Busch, O R C, additional, Buskens, C J, additional, El-Massoudi, Y, additional, Kluit, A B, additional, van Rossem, C C, additional, Schijven, M P, additional, Tanis, P J, additional, Unlu, C, additional, Gerhards, M F, additional, Karsten, T M, additional, de Nes, L C, additional, Rijna, H, additional, van Wagensveld, B A, additional, Koffeman, G I, additional, Steller, E P, additional, Tuynman, J B, additional, Bruin, S C, additional, van der Peet, D L, additional, Blanken-Peeters, C F J M, additional, Cense, H A, additional, Jutte, E, additional, Crolla, R M P H, additional, van der Schelling, G P, additional, van Zeeland, M, additional, de Graaf, E J R, additional, Groenendijk, R P R, additional, Vermaas, M, additional, Schouten, O, additional, de Vries, M R, additional, Prins, H A, additional, Lips, D J, additional, Bosker, R J I, additional, van der Hoeven, J A B, additional, Diks, J, additional, Plaisier, P W, additional, Kruyt, P M, additional, Sietses, C, additional, Stommel, M W J, additional, Nienhuijs, S W, additional, de Hingh, I H J T, additional, Luyer, M D P, additional, van Montfort, G, additional, Ponten, E H, additional, Smulders, J F, additional, van Duyn, E B, additional, Klaase, J M, additional, Swank, D J, additional, Ottow, R T, additional, Stockmann, H B A C, additional, Vermeulen, J, additional, Vuylsteke, R J C L M, additional, Belgers, H J, additional, Fransen, S, additional, von Meijenfeldt, E M, additional, Sosef, M N, additional, van Geloven, A A W, additional, Hendriks, E R, additional, ter Horst, B, additional, Leeuwenburgh, M M N, additional, van Ruler, O, additional, Vogten, J M, additional, Vriens, E J C, additional, Westerterp, M, additional, Eijsbouts, Q A J, additional, Bentohami, A, additional, Bijlsma, T S, additional, de Korte, N, additional, Nio, D, additional, Govaert, M J P M, additional, Joosten, J J A, additional, Tollenaar, R A E M, additional, Stassen, L P S, additional, Wiezer, M J, additional, Hazebroek, E J, additional, Smits, A B, additional, van Westreenen, H L, additional, Lange, J F, additional, Brandt, A, additional, Nijboer, W N, additional, Toorenvliet, B R, additional, Weidema, W F, additional, Coene, P P L O, additional, Mannaerts, G H H, additional, den Hartog, D, additional, de Vos, R J, additional, Zengerink, J F, additional, Hoofwijk, A G M, additional, Hulsewé, K W E, additional, Melenhorst, J, additional, Stoot, J H M B, additional, Steup, W H, additional, Huijstee, P J, additional, Merkus, J W S, additional, Wever, J J, additional, Maring, J K, additional, Heisterkamp, J, additional, van Grevenstein, W M U, additional, Vriens, M R, additional, Besselink, M G H, additional, Borel Rinkes, I H M, additional, Witkamp, A J, additional, Slooter, G D, additional, Konsten, J L M, additional, Engel, A F, additional, Pierik, E G J M, additional, Frakking, T G, additional, van Geldere, D, additional, Patijn, G A, additional, D'Hoore, A J L, additional, de Buck van Overstraeten, A, additional, Miserez, M, additional, Terrasson, I, additional, Wolthuis, A, additional, and De Blasiis, M G, additional

Published
2015
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209. Molecular anatomy of peripheral T cell lymphomas

Author

Pellegrino, Elisa, Agnelli, L, Todoerti, K, Fornari, A, Novero, D, Cuccuru, G, Ferreri, C, Martinoglio, B, Medico, Enzo, Zamò, A, Facchetti, F, De Chiara, A, Ponzoni, M, Rosenwald, A, Müller Hermelink HK, De Wolf Peeters, C, Piccaluga, Pp, Pileri, S, Neri, A, Inghirami, Giorgio, and Piva, Roberto

Published
2009

211. Genomic and functional approaches as powerful tools to stratify human T-cell lymphoproliferative disorders and to identify relevant tumorigenic culprits

Author

Piva, Roberto, Pellegrino, Elisa, Agnelli, L, Grosso, V, Tamagno, I, Ferrantino, L, Cagnoni, G, Fornari, A, Novero, D, Poli, V, Zamò, A, Chiosi, M, Rosenwald, A, Müller Hermelink HK, Vermi, W, Facchetti, F, Fulciniti, F, De Chiara, A, Ponzoni, M, Doglioni, C, Piccaluga, Pp, Pileri, S, De Wolf Peeters, C, Neri, A, and Inghirami, Giorgio

Published
2008

214. Samen kennis ontwikkelen. Proceedings Onderwijs Research Dagen 2006

Author

Beishuizen, J.J., Bos, P., Leeman, Y., Lunenberg, M.L., van Oers, B., van Os, W, Peeters, C., van der Schee, J.A., van der Veer, C.G., Verkleij, A., Volman, M.L.L., Wardekker, W.L., Research and Theory in Education, Methods and Techniques, and Other Research in Social Sciences

Published
2006

216. Inflammatory breast cancer in the Netherlands; improved survival over the last decades.

Author

Uden, D., Bretveld, R., Siesling, S., Wilt, J., and Blanken-Peeters, C.

Abstract

Purpose: Locally advanced breast cancer (LABC) includes inflammatory breast cancer (IBC) as well as non-inflammatory LABC (NI-LABC). The aim of this population-based study was to compare the tumour characteristics, treatment and relative survival of IBC and NI-LABC patients. Methods: Patients with either IBC (cT4d) or NI-LABC (cT4a-c) were identified from the nationwide Netherlands Cancer Registry from the period 1989-2015. In each group, patients are divided into three time periods in order to perform a trend analysis: 1989-1997, 1998-2006, and 2007-2015. Results: IBC comprised 1.1% and NI-LABC 4.6% of all diagnosed breast cancer patients. IBC patients showed more nodal metastases (77.8 vs. 69.7%, P < 0.001) and distant metastases (39.7 vs. 34.1%, P < 0.001). IBC tumours were more often triple negative (23.2 vs. 12.8%, P < 0.001) and poorly differentiated (69.8 vs. 53.8%, P < 0.001). Trimodality therapy (neoadjuvant chemotherapy, surgery and adjuvant radiotherapy) was more often applied over time in both groups (IBC: 23.7% -56.0%-68.6%; NI-LABC: 3.7%-25.9%-43.6%; P < 0.001). In IBC patients, relative 5-year survival was significantly shorter than in patients with NI-LABC (30.2 vs. 45.1%, P < 0.001). The relative survival significantly improved for IBC from 17.2% (1989-1997) to 30.0 and 38.9% for the last two time periods (1998-2006: P < 0.001; 2007-2015: P < 0.001). In contrast, survival did not significantly improve in NI-LABC breast cancer: from 44.7% (1989-1997) to 44.0 and 48.4% (1998-2006: P = 0.483; 2007-2015: P = 0.091). Conclusions: IBC has tumour characteristics that determine its aggressive biology compared to NI-LABC. Trimodality therapy was increasingly applied in both groups, but did not improve survival in NI-LABC. Although relative survival in IBC patients has improved during the last decades, it remains a disease with a dismal prognosis. [ABSTRACT FROM AUTHOR]

Published
2017
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218. Very low genetic variability in the Indian queenless ant Diacamma indicum

Author

Viginier, B., Peeters, C., Brazier, L., Doums, C., Ecologie comportementale (EC), École normale supérieure - Paris (ENS Paris)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Biologie Intégrative des Populations, École pratique des hautes études (EPHE)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1), Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes (UR)-Université Claude Bernard Lyon 1 (UCBL), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, ComputingMilieux_MISCELLANEOUS, [SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis
Abstract

International audience

Published
2004
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219. Fertility signaling and reproductive skew in queenless ants

Author

Cuvillier-Hot, V., Lenoir, A., Crewe, R., Malosse, C., Peeters, C., Ecologie comportementale (EC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes (UR)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Thery, Marc, École normale supérieure - Paris (ENS Paris)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université Claude Bernard Lyon 1 (UCBL), Ecologie comportementale ( EC ), École normale supérieure - Paris ( ENS Paris ) -Institut National de la Recherche Agronomique ( INRA ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Université Paris-Sud - Paris 11 ( UP11 ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), École normale supérieure - Paris (ENS Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1)

Subjects
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], [SDV.OT] Life Sciences [q-bio]/Other [q-bio.OT], [ SDV.OT ] Life Sciences [q-bio]/Other [q-bio.OT], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2004

220. Nodular Lymphocyte Predominant Hodgkin Lymphoma and T cell/Histiocyte Rich Large B Cell Lymphoma Endpoints of a Spectrum of one Disease?

Author

Hartmann, S, primary, Döring, C, additional, Jakobus, C, additional, Rengstl, B, additional, Newrzela, S, additional, Tousseyn, T, additional, Sagaert, X, additional, Ponzoni, M, additional, Facchetti, F, additional, de Wolf-Peeters, C, additional, Steidl, C, additional, Gascoyne, R, additional, Küppers, R, additional, and Hansmann, ML, additional

Published
2014
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222. Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction

Author

Van de Werf, F., Armstrong, P. W., Granger, C., Wallentin, L., Adgey, A. A. J., Aylward, P., Binbrek, A. S., Califf, R., Cassim, S., Diaz, R., Fanebust, R., Fioretti, P. M., Huber, K., Husted, S., Lindahl, B., Lopez-Sendon, J. L., Makijarvi, M., Meyer, J., Navarro Robles, J., Pfisterer, M., Seabra-Gomes, R., Soares-Piegas, L., Sugrue, D., Tendera, M., Theroux, P., Toutouzas, P., Vahanian, A., Verheugt, F., Sarelin, H., Goetz, G., Bluhmki, E., Daclin, V., Danays, T., Houbracken, K., Kaye, J., Reilly, P., Hacke, W., von Kummer, R., Lesaffre, E., Bogaerts, K., Peeters, C., Fox, K. A. A., Brower, R., Hirsh, J., Maggioni, A., Tijssen, J., Weaver, D., Beernaert, A., Beysen, N., Broos, K., De Prins, E., D'Hollander, K., Dupon, L., Fomyna, N., Fransen, A., Genesse, D., Goffin, L., Hendrickx, R., Jansen, B., Jorissen, F., Luys, C., Luyten, A., Marschal, C., Moreira, M., Munsters, K., Salerno, R., Schoovaerts, C., Sinnaeve, P., Schildermans, C., Vandenberghe, K., Vandeschoot, K., Van Gucht, H., Van Rompaey, P., Vlassak, S., Watzeels, M., Wittockx, H., Galan, K., Humeniuk, L., Seidel, A., Molina, M., Hafley, G., Alexander, J., Pascual, A., Bestilny, S., Temple, T., Ahuad Guerrero, R., Albisu, J. P., Bassani Arrieta, C. A., Bono, J., Caccavo, A., Cagnolatti, A., Cartasegna, L. R., Castellanos, R., Chekerdemian, S., Covelli, G., Cuello, J. L., Cuneo, C. A., Fernandez, A., Ferrara, C., Ferro-Queirel, E., Gambarte, A., Garcia-Duran, R., Hasbani, E., Hrabar, A., Keller, L., Lobo Marquez, L. L., Luciardi, H., Macin, S. M., Marinig, A., Marzetti, E., Muntaner, J., Nordaby, R., Orlandini, A. D., Piombo, A. C., Pomposiello, J. C., Quijano, R. A., Amerena, J., Aroney, G., Buckmaster, N., Carroll, P., Fitzpatrick, M., Newman, R., Rowe, M., Singh, B., Thomson, A., Winter, C., Eber, B., Gaul, G. B., Klein, W., Leisch, F., Mayr, H., Mlczoch, J., Niessner, H., Pachinger, O., Pall, H., Pichler, M., Roggla, G., Schaflinger, E., Schreiber, W., Slany, J., Traindl, O., Zenker, G., Beckers, J., Bekaert, I., Berthe, C., Bodur, G., Carlier, B., Carlier, M., Carpentier, J., Celen, H., Charlier, F., Clement, A., Coenen, A., Crochelet, L., De Keyser, F., De Man, F., de Meester, A., Dendale, P., Dhondt, E., Dhooghe, G., El Allaf, D., Elshot, S., Emmerechts, C., Foret, F., Gatera, E., Geraedts, J., Gerardy, A. C., Gysbrechts, M., Hallemans, R., Hellemans, S., Herssens, H., Huygens, L., Janssens, L., Lalmand, J., Maamar, R., Marechal, P., Mertens, D., Michel, P., Morandini, E., Nannan, M., Nguyen, D., Odeurs, W., Peerenboom, P., Pirenne, B., Quinonez, M., Raymenants, E., Renard, M., Silance, P. G., Standaert, A. M., Striekwold, H., Thiels, H., Valadi, D., van Brabandt, H., Van Dormael, M., Van Iseghem, P., Van Walleghem, U., Vanden Bosch, H., Vandenbossche, J. L., Vermylen, J., Verstraete, S., Vo Ngoc, P., Willems, P., Zenner, R., Campos de Albuquerque, D., Coutinho, M., de Camargo Carvalho, A. C., Fernandes Manenti, E. R., Ferreira Azevedo, A., Golin, V., Gun, C., Marin Neto, J. A., Marino, R. L., Miranda Abrantes, J. A., Nicolau, J. C., Porto Alegre Dancini, E. M., Rabelo, A., Ramos, R. F., Rizzi Coelho, O., Alexander, D., Bata, I. R., Bhargava, R. K., Bogaty, P., D'Amours, G., Darcel, I., Finnie, K. J. C., Fowlis, R., Gupta, M. K., Henderson, M., Howlett, M. K., Javier, J. J., Kieu, C. V., Kumar, G., Lebouthillier, P., Leduc, F., Lepage, S., Mcavinue, T., Mcgillen, J. E., Mcmeekin, J. D., Morse, J. W., Pistawka, K., Raimondo, E. F., Sandrin, F., Smith, H., Smylie, P. C., Tran, K., Turabian, M., Wagner, K. R., Winkler, L. H., Woo, K. S., Falstie-Jensen, N., Lind Rasmussen, S., Lomholt, P., Markenvard, J., Nielsen, H., Petersen, J., Romer, F., Ahonen, J., Huttunen, M., Kokkonen, L., Luukkonen, J., Mantyla, P., Melin, J., Mustonen, J., Valli, J., Voutilainen, S., Agraou, B., Allam, S., Baradat, G., Battistella, P., Bazin, P., Bouvier, J. -M., Destrac, S., Fouche, R., Fournier, P. -Y., Funck, F., Garnier, H., Grall, J. -Y., Gully, C., Lallement, P. -Y., Loiselet, P., Mycinsky, C., Page, A., Parisot, M., Range, G., Rocher, R., Tafani, C., Thisse, J. -Y., Tibi, T., Tissot, M., Wahl, P., Backenkohler, U., Bavastro, P., Beckmann-Hiss, H., Behnke, M., Bermes, M., Bernsmeier, R., Bethge, K. P., Bethge, H., Block, M., Burkhardt, W., Cieslinski, G., Claus, G., Deetjen, A., Diefenbach, A., Diehm, C., Dietz, A., Dippold, W. G., Eichner, A., Erckenbrecht, J. F., Gawlick, L., Gerber, V., Goppel, L., Gottwik, M., Grosch, B., Hammer, B., Hanheide, M., Hanrath, P., Haspel, J., Hennersdorf, F., Hermanns, M., Hoffmeister, H. M., Holzapfel, P., Hubner, H., Jansen, W., Jung, S., Kaddatz, J., Kienbock, H., Klein, H. H., Konz, K. H., Kulschbach, M., Leschke, M., Liebau, G., Linnartz, M., Lockert, G., Loesbrock, R., Lollgen, H., Ludwig, N., Mudra, H., Munzer, K., Nebel, B., Nellessen, U., Neu, C., Olbrich, H. G., Pfeffer, A., Pfeiffer, P., Plate, V., Pollock, B., Rapp, H., Rommele, U., Sauer, K., Scheffler, N., Schlotterbeck, K., Schmidt-Salzmann, A., Schnitzler, G., Schumann, H., Schuster, C. J., Schuster, P., Schweizer, P., Seitz, K., Simon, R., Spes, C., Szabo, S., Terhardt-Kasten, E., Theuerkauf, B., Tigges, R., Tinnappel, J., Topp, H., Trockel, P., Unland, N., Veth, V., Vom Dahl, J., Vossbeck, G., Weindel, K., Weib, D., Wiewel, D., Wirtz, P., Zipp, C., Apostolou, T., Chalkidis, C., Exadaktylos, N., Foussas, S., Hatseras, D., Karas, S., Karydis, K., Lambrou, S., Louridas, G., Manolis, A., Nanas, J., Novas, I., Panagiotidou, T., Papadopoulos, C., Papakonstantinou, D., Papasteriadis, E., Pavlidis, P., Pyrgakis, V., Skoufas, P., Stavrati, A., Tyrologos, A., Vardas, P., Vrouchos, G., Zacharoulis, A., Zarifis, J., Brown, A., Daly, K., Fennell, W., Horgan, J., Mccann, H., Mcdonald, K., O'Reilly, M., Sullivan, P., Altamura, G., Ambrosio, G., Auteri, A., Aveta, P., Azzarito, M., Badano, L. P., Barbiero, M., Barletta, C., Biscosi, C., Boccanelli, A., Bottero, M., Brizio, E., Brunazzi, M. C., Brunelli, C., Bugatti, U., Capozi, A., Capucci, A., Carfora, A., Caronna, A., Carrone, M., Casazza, F., Cauticci, A., Ceci, V., Ciconte, V., Circo, A., Ciricugno, S., Comito, F., Cornacchia, D., Corsini, G., D'Andrea, F., De Rosa, P., De Simone, M., Del Citerna, F., Del Pinto, M., Dell'Ali, C., Della Casa, S., Della Monica, R., Delogu, G., Di Biase, M., Di Chiara, A., Di Guardo, G., Di Marco, S., Di Mario, F., Di Napoli, T., Di Palma, F., Fadin, B. M., Fazzari, M., Ferraiuolo, G., Fiaschetti, R., Fontanelli, A., Fresco, C., Gambelli, G., Gasbarri, F., Gemelli, M., Giani, P., Gigantino, A., Giomi, A., Giorgi, G., Greco, C., Gregorio, G., Guagnozzi, G., Guiducci, U., Guzzardi, G., Izzo, A., La Rosa, A., Leone, F., Leone, G., Lo Bianco, F., Locuratolo, N., Maggiolini, S., Malinconico, M., Mancone, C., Mangiameli, S., Marchi, S. M., Maresta, A., Mauri, F., Mazzini, C. A., Michisanti, M., Miracapillo, G., Modena, M. G., Morgagni, G. L., Mossuti, E., Nascimbeni, F., Negrelli, M., Notaristefano, A., Pardi, S., Peci, P., Pettinati, G., Pietropaolo, F., Pirelli, S., Pretolani, M., Prinzi, D., Proietti, F., Raganelli, L., Rapino, S., Re, F., Ricci, R., Rinaldi, G., Rusticali, G., Severi, S., Spallarossa, P., Tartagni, F., Terrosu, P., Tortorella, G., Tota, F., Tritto, I., Tuccilo, B., Turco, V., Uscio, G., Valagussa, F., Vergoni, W., Verzuri, M. S., Vetrano, A., Villani, R., Zanini, R., Boisante, L., Niclou, R., Alcocer, L., Castro, A., Fragoso, J., Gonzalez, V., Gonzalez-Pacheco, H., Hernandez-Santamaria, I., Huerta, R., Huerta, D., Martinez, A., Mendoza, M., Moguel, R., Navarro, J., Portos, J. M., Rodriguez, I., Sierra, L., Valencia, S., Vazquez, A., Arnold, A. E. R., Boehmer, A. G., de Graaf, J. J., Funke Kupper, A. J., Gobel, E. J. A. M., Janus, C. L., Linssen, G. C. M., Sedney, M. I., Slegers, L. C., Spierenburg, H. A. M., Strikwerda, S., Tans, J. G. M., Twisk, S. P. M., van der Heijden, R., van Kalmthout, P. M., Verheugt, F. W. A., Holt, E., Skogsholm, A., Thorshaug, R., Thybo, N. K., Wang, H., Maciejewicz, J., Piotrowski, W., Pluta, W., Ruminski, W., Skura, M., Smielak-Korombel, W., Carranca, J., Carvalho, M., Catarino, C., Cunha, D., Ferreira, D., Ferreira, J., Ferreira da Costa, A. F., Lopes de Carvalho, J., Martins, L., Mourao, L., Oliveira Carrageta, M., Prazeres de Sa, E., Puig, J., Ramalho Dos Santos, M. J. J., Resende, M., Seabra Gomes, R., Baig, M. M. E., Bayat, J., Benjamin, J. D., Ranjith, N., Routier, R., Wittmer, H., Abizanda Campos, R., Alonso Garcia, M. A., Amaro Cendon, A., Arboleda Sanchez, J. A., Blanco Varela, J., Bruguera I Cortada, J., Carpintero Avellaneda, J. L., Caturla Such, J., Civeira Murillo, E., Fernandez Aviles, F., Fernandez Fernandez, R., Figueras Bellot, J., Fiol Sala, M., Froufe Sanchez, J., Garcia Calabozo, R., Garcia Palacios, J. L., Gonzalez Maqueda, I., Kallmeyer Martin, C., Lopez Sendon, J. L., Manzano Ramirez, A., Marine Rebull, J., Monton Rodriguez, A., Pique Gilart, M., Reina Toral, A., Rodriguez Llorian, A., Ruano Marco, M., Sanchez Miralles, A., Sanjose Garagarza, J. M., Santalo Bel, M., Torres Ruiz, J. M., Valentin Segura, V., Ahlstrom, P., Ahremark, U., Bandh, S., Bellinetto, A., Dahlberg, A., Hansen, O., Hurtig, U., Jonasson, L., Karlsson, J. E., Larsson, L. E., Moller, B., Ohlin, H., Persson, H., Sandstedt, L., Soderberg, S., Svennberg, L., Swahn, E., Tygesen, H., Broccard, A. F., Estlinbaum, W., Follath, F., Frutiger, A., Hess, N., Maggiorini, M., Marti, D., Muller, P., Rickenbacher, P., Schaller, M. D., Weinbacher, M., Abdulali, S., Ahmad, G., George, S., Ghazi, A., Rao, K. N., Bishop, A., Bridges, A., Canepa-Anson, R., Cave, M., Clarck, R., Cooper, I., de Belder, A., Farrer, M., Kendall, J. M., Ludman, P., Mattu, R., Mcglinchey, P., Moriarty, A. J., Muthusamy, S., Nee, P. A., Nolan, J., Papouchado, M., Rose, E. L., Shahi, M., Stephens, J., Trevelyan, J., Abdul-Karim, A., Adler, L., Arunasalam, S., Avington, D., Baron, S., Beel, T., Bellamy, B., Bennett, J., Berndt, T., Berrick, A., Bersin, R. M., Bethala, V., Bharath, S., Bouchard, A., Boulet, J. E., Bowerman, R., Boyek, T., Brar, R. S., Brodell, G., Bryant, B., Buckner, J. K., Cage, J., Cannon, J. D., Carducci, B., Carr, K., Chang, M., Chelliah, N., Chin, W. L., Chin, J., Church, D. H., Clark, R., Coulis, L., Dadkhah, S., Dearing, B., Defranco, A., Dharawat, M., Dharawat, R., Dhruva, N., Dicola, J., Dykstra, G., Eisenberg, S., El-Bialy, A., Fera, S., Ford, K., Foreman, R. D., Friedman, S., Friedman, V., Garibian, G., Gelormini, J., Geninatti, M. R., Genovese, R., Ghazi, F., Gilchrist, I., Gitler, B., Glover, R., Gonzalez, J., Goulah, R., Graham, B., Gray, R., Grodman, R., Habib, G. B., Hack, T., Hamroff, G., Hanna, G., Hart, M., Haught, H., Hawkins, J., Hempel, R., Hiremath, Y., Hiser, W., Holland, E., Jaffe, N., Jamal, N., James, K. F., Kalla, S., Kates, M., Kemper, A. J., Kennedy, J. J., Kerut, E. K., Killpack, M., King, J., T. Y., Ko, Kollar, K., Kontos, M., Kugelmassluu, A., Kumar, A., Kutscher, A. H., Lambrecht, C., Lancaster, L., Layden, J., Lazar, A., Lebow, M., Lee, C., Lee, A. B., Lehr, J., Levin, F. L., Levitt, R., Levy, R. M., Lieberman, A., Litman, G. I., Lui, H., Luu, M. Q., Macdonald, G., Madyoon, H., Mancherje, C., Marmulstein, M., Mclaurin, B. T., Mcnellis, M., Mendelson, R., Micale, P. J., Miller, M. J., Miller, M. S., Miller, J., Millman, A., Millsaps, R., Minor, S., Modica, J., Morse, H., Moskovits, N., Nester, B. A., Newton, A. S., Niazi, I., Niederman, A., Oatfield, R., Painter, J. A., Pamfilis, S. M., Pamulapati, K. M., Patel, N., Payne, R., Pearson, C., Peizner, D. S., Petrovich, L., Piriz, J., Pollack, M., Pollock, S., Popkave, A., Puma, J. A., Quesada, R., Quigley-Malcolm, D., Raby, K., Ravindran, K., Rees, A. P., Reiner, J., Rivera, E., Rogers, F., Rosenthal, A., Rowe, W. W., Ryan, P. F., Ryman, K., Salacata, A., Santolin, C., Saucedo, J., Savage, R., Savage, W., Schumacher, R., Segarra, S., Sharkey, S., Shonkoff, D., Silver, M., Silver, S. L., Singh, G., Sinyard, R. D., Sporn, D., Srivastava, N. K., Stomel, R., Suresh, D. P., Tallman, M., Togioka, T., Varma, S., Verant, R. P., Wallach, R., Weinberg, M., Weinberg, D., Weinstein, J. M., Wesley, G., Westerman, J. H., Wheeling, J., Whitaker, J., Widmer, M., Yasin, M., and Zakrzewski, M. J.

Subjects
Male, medicine.medical_specialty, Abciximab, Ischemia, Myocardial Infarction, Tenecteplase, Injections, Immunoglobulin Fab Fragments, Reperfusion therapy, Fibrinolytic Agents, Recurrence, Internal medicine, medicine, Humans, Myocardial infarction, Enoxaparin, Aged, Intention-to-treat analysis, Chi-Square Distribution, business.industry, Heparin, Antibodies, Monoclonal, General Medicine, Middle Aged, medicine.disease, Survival Analysis, Regimen, Treatment Outcome, Anesthesia, Tissue Plasminogen Activator, Cardiology, Drug Therapy, Combination, Female, business, Platelet Aggregation Inhibitors, medicine.drug
Abstract

BACKGROUND: Current fibrinolytic therapies fail to achieve optimum reperfusion in many patients. Low-molecular-weight heparins and platelet glycoprotein IIb/IIIa inhibitors have shown the potential to improve pharmacological reperfusion therapy. We did a randomised, open-label trial to compare the efficacy and safety of tenecteplase plus enoxaparin or abciximab, with that of tenecteplase plus weight-adjusted unfractionated heparin in patients with acute myocardial infarction. METHODS: 6095 patients with acute myocardial infarction of less than 6 h were randomly assigned one of three regimens: full-dose tenecteplase and enoxaparin for a maximum of 7 days (enoxaparin group; n=2040), half-dose tenecteplase with weight-adjusted low-dose unfractionated heparin and a 12-h infusion of abciximab (abciximab group; n=2017), or full-dose tenecteplase with weight-adjusted unfractionated heparin for 48 h (unfractionated heparin group; n=2038). The primary endpoints were the composites of 30-day mortality, in-hospital reinfarction, or in-hospital refractory ischaemia (efficacy endpoint), and the above endpoint plus in-hospital intracranial haemorrhage or in-hospital major bleeding complications (efficacy plus safety endpoint). Analysis was by intention to treat. FINDINGS: There were significantly fewer efficacy endpoints in the enoxaparin and abciximab groups than in the unfractionated heparin group: 233/2037 (11.4%) versus 315/2038 (15.4%; relative risk 0.74 [95% CI 0.63-0.87], p=0.0002) for enoxaparin, and 223/2017 (11.1%) versus 315/2038 (15.4%; 0.72 [0.61-0.84], p

Published
2001

223. Local optical studies of periodic air rod arrays

Author

Kuipers, L., Peeters, C., Flück, E., Balistreri, M.L.M., Otter, A.M., van Hulst, N.F., and Optical Sciences

Subjects
Condensed Matter::Materials Science, Condensed Matter::Superconductivity, Physics::Optics, METIS-130189, IR-25388
Abstract

We present an investigation of local optical field distributions inside low-dimensional photonic crystals with a scanning tunnelling microscope (STM). Channel waveguides form the basis for our photonic crystals. We have modified the waveguides by means of focused ion beam sputtering.

Published
2000

224. Looking into photonic structures with a photon scanning tunneling microscope

Author

Kuipers, L., Peeters, C., Flück, E., Balistreri, M.L.M., Otter, A.M., van Hulst, N.F., Lenstra, D., Visser, T.D., and Optical Sciences

Subjects
Physics::Optics, METIS-130179, IR-25378
Abstract

In periodic structures photons can be made to behave like electrons. This results in the opening of a so called "photonic stop gap", a range of forbiddden optical frequencies that cannot exist inside the material. To investigate such photonic materials on the nanoscale we will use state-of-the art scanning probe technologies. This allows us to map the optical field distribution and the phase of the light simultaneously with the topographical information of the structure. Such measurements on photonic materials will complement standard investigation methods, such as in/output measurements. Our ultimate goal is to find out what happens to an excited individual molecule located inside the photonic materials, when it "wants" to fluoresce at a forbidden frequency in the gap. Will it emit a photon, yes or no?

Published
2000

225. Different gastritis features are linked to different gastric neoplasms

Author

Driessen, A., Ectors, N., Cutsem, E., Penninckx, F., Filez, L., Pittaluga, S., Jan Delabie, Wolf-Peeters, C., and Geboes, K.

Subjects
Adult, Male, Helicobacter pylori, Lymphoma, Gastric Mucosa, Stomach Neoplasms, Gastritis, Carcinoma, Humans, Female, Atrophy, Middle Aged, Aged
Abstract

Helicobacter pylori infection induces gastritis, which may evolve to carcinoma or lymphoma. Whether duration of infection and inflammation pattern determine the outcome of the neoplastic process is not known. The aim of this study was to investigate the features of the gastritis associated with neoplasia.Gastritis found in association with carcinoma (100 cases) and lymphoma (45 cases) were graded using the Sydney system.In particular in the antrum, gastric carcinomas, in particular of the intestinal type, were associated with a chronic (94%, n = 34/36) atrophic (92%, n = 33/36) gastritis and intestinal metaplasia (81%, n = 29/36). In diffuse type carcinomas inflammation was either absent or mild. An active (64%, n = 16/25), chronic gastritis (100%, n = 25/25) with lymphoid hyperplasia (72%, n = 18/25) was found in marginal zone cell lymphoma.Our study shows that the (pre)atrophic phases of inflammation are associated with gastric carcinomas. In contrast the active phase of inflammation, characterized by severe activity as well as severe chronicity, is found next to marginal zone cell lymphoma.

Published
1999

226. Detection of immunoglobulin kappa light chain rearrangements by polymerase chain reaction. An improved method for detecting clonal B-cell lymphoproliferative disorders

Author

Gong, Jz, Zheng, S, Chiarle, Roberto, De Wolf Peeters, C, Palestro, G, Frizzera, G, and Inghirami, Giorgio

Subjects
Leukemia, Lymphoma, Technical Advance, Tumor Cells, Cultured, Gene Rearrangement, B-Lymphocyte, Light Chain, Humans, Electrophoresis, Polyacrylamide Gel, Lymph Nodes, Polymerase Chain Reaction, Lymphoproliferative Disorders, Polymorphism, Single-Stranded Conformational, Clone Cells
Abstract

The clonal determination of B-cell lymphoproliferative disorders by immunoglobulin heavy chain (IgH) rearrangement by polymerase chain reaction (PCR) is widely used. However, few attempts have been made to detect immunoglobulin kappa light chain (Igkappa) gene rearrangement using PCR. We studied 145 cases of B-cell neoplasms, along with 58 atypical and 18 reactive lymphoproliferative disorders, using newly designed degenerate oligoprimers recognizing the framework 3 (FR3kappa) and the joint (Jkappa) regions of the Igkappa gene. PCR products were analyzed on nondenaturing polyacrylamide gel (ndPAGE). Clonal B-cell determination was further investigated using IgH rearrangement and t(11:14) or t(14:18). By combining these methods, we detected either clonality or translocation in 117 of 137 cases (85%) in mature B-cell neoplasms. The additional analysis of Igkappa rearrangement improved sensitivity from 66% to 85%. To investigate whether the Ig gene configuration could be characterized using Igkappa PCR in B-cell neoplasms showing severe breakdown of genomic DNA, 18 selected cases were analyzed. Successful amplification was detected in 72% of the cases using either FR3/2-JH and/or FR3Jkappa oligoprimers. Finally, clonality was detected in 21 of 58 atypical B-cell proliferations, and among them, the atypical marginal cell (54%) and atypical large cell (50%) proliferations showed the highest frequency of clonal immunoglobulin gene products. We concluded that PCR/ndPAGE analysis of Igkappa is a sensitive, rapid, and efficient method for assessing clonality in conjunction with IgH and specific translocation analysis. This approach is particularly useful in the characterization of B-cell lymphoproliferative disorders in archival material with poor preservation of the genomic DNA.

Published
1999

228. De Koninklijke Marine: economische betekenis en structuur

Author

Peeters, C., Joos, K., Van der Linden, J., and Lefever, A.

Subjects
Koninklijke Marine, economische impact studie, maritieme cluster
Abstract

In opdracht van: Stichting Nederland Maritiem Land uitgevoerd door: Policy Research Corporation N.V.

Published
1999

231. ALK+ lymphoma: clinico-pathological findings and outcome

Author

Santucci, A., Martelli, Mf, Flenghi, L., Pelicci, Pg, Fizzotti, M., Araujo, I., Foss, Hd, Aiello, A., Giardini, R., Lazzarino, M., Marco Paulli, Todeschini, G., Menestrina, F., Verhoef, G., Wolf-Peeters, C., Zagonel, V., Carbone, A., Zinzani, Pl, Pileri, S., and Falini, B.

Published
1999

233. Differential expression of NF-kappa B target genes in MALT lymphoma with and without chromosome translocation: insights into molecular mechanism

Author

UCL, Hamoudi, R. A., Appert, A., Ye, H., Ruskone-Fourmestraux, A., Streubel, B., Chott, A., Raderer, M., Gong, L., Wlodarska, Iwona, De Wolf-Peeters, C., MacLennan, K. A., de Leval, L., Isaacson, P. G., Du, M-Q, UCL, Hamoudi, R. A., Appert, A., Ye, H., Ruskone-Fourmestraux, A., Streubel, B., Chott, A., Raderer, M., Gong, L., Wlodarska, Iwona, De Wolf-Peeters, C., MacLennan, K. A., de Leval, L., Isaacson, P. G., and Du, M-Q

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is characterized by t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH and t(14;18)(q32;q21)/IGH-MALT1, which commonly activate the nuclear factor (NF)-kappa B pathway. Gastric MALT lymphomas harboring such translocations usually do not respond to Helicobacter pylori eradication, while most of those without translocation can be cured by antibiotics. To understand the molecular mechanism of these different MALT lymphoma subgroups, we performed gene expression profiling analysis of 21 MALT lymphomas (13 translocation-positive, 8 translocation-negative). Gene set enrichment analysis (GSEA) of the NF-kappa B target genes and 4394 additional gene sets covering various cellular pathways, biological processes and molecular functions have shown that translocation-positive MALT lymphomas are characterized by an enhanced expression of NF-kappa B target genes, particularly toll like receptor (TLR)6, chemokine, CC motif, receptor (CCR)2, cluster of differentiation (CD) 69 and B-cell CLL/lymphoma (BCL)2, while translocation-negative cases were featured by active inflammatory and immune responses, such as interleukin-8, CD86, CD28 and inducible T-cell costimulator (ICOS). Separate analyses of the genes differentially expressed between translocation-positive and -negative cases and measurement of gene ontology term in these differentially expressed genes by hypergeometric test reinforced the above findings by GSEA. Finally, expression of TLR6, in the presence of TLR2, enhanced both API2-MALT1 and BCL10-mediated NF-kappa B activation in vitro. Our findings provide novel insights into the molecular mechanism of MALT lymphomas with and without translocation, potentially explaining their different clinical behaviors. Leukemia (2010) 24, 1487-1497; doi:10.1038/leu.2010.118; published online 3 June 2010

Published
2010

234. Non-ig Mediated Aberrations of Foxp1 in Human B Cell Lymphoma

Author

UCL - Autre, Rouhigharabaei, L., Tousseyn, Thomas, Haralambieva, E., Maes, B., Vicente, C., Vandenberghe, Peter, de Wolf-Peeters, C., Cools, Jan, Wlodarska, Iwona, 15th Annual Meeting of the European-Hematology-Association, UCL - Autre, Rouhigharabaei, L., Tousseyn, Thomas, Haralambieva, E., Maes, B., Vicente, C., Vandenberghe, Peter, de Wolf-Peeters, C., Cools, Jan, Wlodarska, Iwona, and 15th Annual Meeting of the European-Hematology-Association

Abstract

Background. The FOXP1 forkhead transcription factor is targeted by rare but recurrent translocations in B-NHL, particularly marginal zone lymphoma (MZL) and diffuse large B-cell lymphoma (DLBCL). The most common is IGH-mediated t(3;14)(p14;q32) resulting in deregulation of FOXP1 transcription by regulatory sequences of IGH. Several translocations of FOXP1 involving non-IG loci have been described, but remain uncharacterized at the molecular level. Aims. This study aimed at genetic and molecular characterization of non-IG FOXP1 aberrations identified in 4 lymphoma cases. Methods. FISH with a panel of BAC probes was applied to map the affected breakpoints at 3p14/FOXP1 and 2q36, 3q11-q13 and 10q24. Expression of FOXP1 mRNA was analyzed by quantitative RT-PCR (QRT-PCR) with primers specific for exons 5-6, 7-8, 11-12, 14-15 and 17-18. Expression of FOXP1 protein was demonstrated by immunohistochemistry (IHC) with the JC12 antibody. Results. All 4 cases showed an aberrant expression of FOXP1 protein by IHC. Three of them displayed various 3p14 aberrations including t(2;3)(q36;p14) (C1) (MZL), inv(3)(p14;q11) (C2) (MZL) and t(3;10)(p14;q24) (C3) (CLL in Richter transformation). In one case of DLBCL (C4) a non-IG t(FOXP1) was detected by interphase FISH. In contrast to lymphomas with t(3;14) showing the 3p14 breakpoints in the 5’end of FOXP1, all cases with non-IG FOXP1 rearrangements displayed breakpoints in the 3’end of the gene. The reciprocal breakpoints were mapped within AP1S3 at 2q36 (C1), in a region at 3q11 lacking known genes (C2) and close to NFKB2 at 10q24 (C3). In C1, AP1S3 has an opposite transcriptional orientation to FOXP1, which precludes the role of its 5’ promoter in deregulation of FOXP1. Also the mechanism of FOXP1 overexpression in C2 with inv(3) affecting no known gene locus at 3q11 remains unknown. To check the hypothesis that non-IG translocations of FOXP1 result in an aberrant expression of variant FOXP1 transcripts, we performed exon-specific QRT

Published
2010

237. Workshop report on Hodgkin's disease and related diseases ('grey zone' lymphoma)

Author

Rudiger, T, Jaffe, ES, Delsol, G, deWolf-Peeters, C, Gascoyne, RD, Georgii, A, Harris, NL, Kadin, ME, MacLennan, KA, Poppema, S, Stein, H, Weiss, LE, and Muller-Hermelink, HK

Subjects
EXPRESSION, Hodgkin's lymphoma, workshop report, DISORDERS, ORIGIN, grey zone, T-CELL, CLASSIFICATION, immune system diseases, hemic and lymphatic diseases, B-CELLS, MARKER, differential diagnosis, immunohistochemistry, pathology, REED-STERNBERG CELLS, COMPOSITE LYMPHOMA
Abstract

Despite advances in immunohistochemistry and molecular biology, the distinction between classical Hodgkin's lymphoma and related diseases such as nodular lymphocyte-predominant Hodgkin's disease, T-cell rich large B-cell lymphoma or anaplastic large cell lymphoma has remained difficult in rare cases. Lack of clear-cut diagnostic criteria represents a problem for both the pathologist and the clinician. To delineate this 'grey zone' between classical Hodgkin's lymphoma and non-Hodgkin's lymphoma (NHL) and to develop criteria for classification of such cases, 12 expert hematopathologists each submitted one to five borderline cases to a workshop. Cases were reviewed and classified at a multiheaded microscope and criteria were established for the diagnosis of questionable cases. Well established entities such as classical Hodgkin's lymphoma? anaplastic large-cell lymphoma and TCRBCL were defined more strictly and cases with unusual morphology or antigen expression could be identified. A distinctive subset of cases representing mediastinal large B-cell lymphomas with features of Hodgkin's lymphoma was identified.

Published
1998

238. Maintenance of remission with human recombinant interferon alpha-2a in patients with stages III and IV low-grade malignant non-Hodgkin's lymphoma

Author

Hagenbeek, A., Carde, P., Meerwaldt, J.H., Somers, R., Thomas, J., Bock, R. de, Raemaekers, J.M.M., Hoof, A. van, Wolf-Peeters, C. de, and Glabbeke, M. van

Subjects
Klinische betekenis van kwantitatieve bcl-2 monitoring tijdens en na behandeling van patienten met laaggradig folliculair non-Hodgkin lymfoom myeloïde leukemie, Clinical significance of quantitative bcl-2 monitoring during and after treatment of patients with low-grade follicular non-Hodgkin's lymphoma
Abstract

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Published
1998

241. Involvement of the Notch1 and Notch2 genes in B-cell lymphomagen

Author

UCL - Cliniques universitaires Saint-Luc, UCL - MD/MNOP - Département de morphologie normale et pathologique, UCL - MD/MINT - Département de médecine interne, Wlodarska, Iwona, Michaux, Lucienne, De Keersmaecker, Kim, Cools, Jan, De Wolf-Peeters, C., Bosly, André, Delos, Monique, Vanhentenrijk, P., Hagemeijer, Anne, Marynen, Peter, UCL - Cliniques universitaires Saint-Luc, UCL - MD/MNOP - Département de morphologie normale et pathologique, UCL - MD/MINT - Département de médecine interne, Wlodarska, Iwona, Michaux, Lucienne, De Keersmaecker, Kim, Cools, Jan, De Wolf-Peeters, C., Bosly, André, Delos, Monique, Vanhentenrijk, P., Hagemeijer, Anne, and Marynen, Peter

Published
2007

242. Partiële ruptuur van de musculus obturatorius externus bij een profvoetballer.

Author

Peeters, C. M. M., van Loon, C. J. M., Sengkerij, P. M., van Kints, M. J., and de Visser, E.

Abstract

Copyright of Sport & Geneeskunde is the property of Arko Sports Media and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016

243. Gamergates (mated egg-laying workers) and queens both reproduce in Euponera sikorae ants from Madagascar.

Author

Peeters, C. and Fisher, B. L.

Subjects
*PACHYCONDYLA, *SPERMATHECA, *ANIMAL exoskeletons, *PREDATION, *ODONTOMACHUS
Abstract

Most ponerine ants have flying queens that monopolise sexual reproduction, but in a minority of species, workers can also mate and lay fertilised eggs. Such 'gamergates' reproduce in addition to queens in some species but have replaced queens entirely in other species. The occurrence of a functional spermatheca in workers often appears associated with a slight difference in body size relative to winged queens, as is the case in Euponera sikorae (Forel) studied here. Eight colonies (19.9±8.7 workers and 0-2 dealate queens) were collected in humid forests of Madagascar. A mated queen reproduced in most colonies, but ovarian dissections indicated that 1-3 workers were also inseminated, and one of these laid eggs if the original founding queen was missing or no longer fecund. Exoskeleton remains (including 29 heads) of a staphylinid beetle were found in one nest of E. sikorae, pointing to specialised predation. We review the occurrence of non-flying reproductives (gamergates and ergatoid queens) in Odontomachus genus-group. [ABSTRACT FROM AUTHOR]

Published
2016
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244. De maritieme arbeidsmarkt: Vraag en aanbod van zeevaartkennis

Author

Peeters, C., Vandendriessche, P., Webers, H., Van der Aa, R., Donker van Heel, P., Van Polanen Petel, V., and Otten, H.

Subjects
arbeidsmarkt, maritiem onderwijs, zeevaartsector, zeevaartonderwijs, personeelsbeleid, maritieme sector
Abstract

in opdracht van Ministerie van Verkeer en Waterstaat Directoraat-Generaal Goederenvervoer

Published
1997

246. CD40 is a prognostic marker in primary cutaneous malignant melanoma

Author

Jj, Den Oord, Maes A, Stas M, Johan Nuyts, Battocchio S, Kasran A, Garmyn M, De Wever I, and De Wolf-Peeters C

Subjects
Membrane Glycoproteins, Skin Neoplasms, CD40 Ligand, Biomarkers, Tumor, Humans, hemic and immune systems, CD40 Antigens, Ligands, Prognosis, Melanoma, Survival Analysis, Research Article
Abstract

CD40 is a receptor at the surface of B lymphocytes with important functions in the immune response. CD40 has also been found on a variety of carcinoma and melanoma cell lines where it has been suggested to serve as a possible receptor for mitogenic signals. We studied the expression and distribution of CD40 in paraffin sections of 71 uniformly treated malignant melanomas (MMs) with a long clinical follow-up using well known monoclonal antibodies. For comparison, 71 benign nevi were also studied. Common acquired nevi occasionally expressed CD40 in nests or single cells at the dermo-epidermal junction; no immunoreactivity was observed in the dermal part of acquired nevi, and all Spitz' nevi were entirely negative. One-third of large congenital nevi expressed CD40 in small clusters of heavily pigmented, epithelioid cells, corresponding to so-called proliferative nodules. In 41 of 71 MMs, CD40 was expressed in single or clustered neoplastic melanocytes; 9 cases showed CD40 expression only in the radial growth phase, and in 32 cases, the vertical growth phase showed CD40 expression. The same staining pattern was obtained with other anti-CD40 monoclonal antibodies, directed to different epitopes of the CD40 molecule. In 29 of 32 MMs showing CD40 in the vertical growth phase, expression of the CD40 ligand (CD40L) was studied; in 13 of these 29, CD40L was found in the same tumor areas that expressed CD40. Analysis of 28 metastases from 24 MM patients showed in the majority of cases a similar, scattered or nodular staining pattern as observed in the primary tumor. Patients expressing CD40 in the vertical growth phase of their MM did not differ significantly from CD40-negative patients with respect to any of the known prognostic parameters but showed a significantly shorter tumor-free survival. Patients with CD40+ CD40L+ MM tended to have a shorter tumor-free survival than those lacking CD40L. We conclude that CD40 represents a novel prognostic parameter in primary cutaneous MM. The co-localization of CD40 and CD40L suggests an autocrine growth loop in the vertical growth phase of MM.

Published
1996

247. FOXP1, a gene highly expressed in a subset of diffuse large B-cell lymphoma, is recurrently targeted by genomic aberrations

Author

UCL - MD/MINT - Département de médecine interne, UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service d'hématologie, Wlodarska, Iwona, Veyt, E, De Paepe, P, Vandenberghe, Peter, Nooijen, P, Théate, Ivan, Michaux, Lucienne, Sagaert, X, Marynen, Peter, Hagemeijer, Anne, De Wolf- Peeters, C, UCL - MD/MINT - Département de médecine interne, UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service d'hématologie, Wlodarska, Iwona, Veyt, E, De Paepe, P, Vandenberghe, Peter, Nooijen, P, Théate, Ivan, Michaux, Lucienne, Sagaert, X, Marynen, Peter, Hagemeijer, Anne, and De Wolf- Peeters, C

Abstract

The transcription factor Forkhead box protein P1 (FOXP1) is highly expressed in a proportion of diffuse large B-cell lymphoma (DLBCL). In this report, we provide cytogenetic and fluorescence in situ hybridization ( FISH) data showing that FOXP1 (3p13) is recurrently targeted by chromosome translocations. The genomic rearrangement of FOXP1 was identified by FISH in three cases with a t(3;14)(p13;q32) involving the immunoglobulin heavy chain (IGH) locus, and in one case with a variant t(2;3) affecting sequences at 2q36. These aberrations were associated with strong expression of FOXP1 protein in tumor cells, as demonstrated by immunohistochemistry (IHC). The cases with t(3p13) were diagnosed as DLBCL ( x 1), gastric MALT lymphoma ( x 1) and B-cell non-Hodgkin's lymphoma, not otherwise specified ( x 2). Further IHC and FISH studies performed on 98 cases of DLBCL and 93 cases of extranodal marginal zone lymphoma showed a high expression of FOXP1 in approximately 13 and 12% of cases, respectively. None of these cases showed, however, FOXP1 rearrangements by FISH. However, over-representation of the FOXP1 locus found in one additional case of DLBCL may represent another potential mechanism underlying an increased expression of this gene.

Published
2005

248. NOTCH1 is targeted by Ig translocations in NHL

Author

UCL - Cliniques universitaires Saint-Luc, UCL - MD/MNOP - Département de morphologie normale et pathologique, UCL - MD/MINT - Département de médecine interne, Wlodarska, W, Michaux, Lucienne, De Wolf-Peeters, C., Cools, Jan, Minnei, F, Bosly, André, Delos, Monique, Vandenberghe, Peter, Hagemeijer, Anne, Marynen, Peter, 47th Annual Meeting of the American-Society-of-Hematology, UCL - Cliniques universitaires Saint-Luc, UCL - MD/MNOP - Département de morphologie normale et pathologique, UCL - MD/MINT - Département de médecine interne, Wlodarska, W, Michaux, Lucienne, De Wolf-Peeters, C., Cools, Jan, Minnei, F, Bosly, André, Delos, Monique, Vandenberghe, Peter, Hagemeijer, Anne, Marynen, Peter, and 47th Annual Meeting of the American-Society-of-Hematology

Published
2005

249. The accuracy of positron emission tomography in the detection of posttransplant lymphoproliferative disorder

Author

Dierickx, D., primary, Tousseyn, T., additional, Requile, A., additional, Verscuren, R., additional, Sagaert, X., additional, Morscio, J., additional, Wlodarska, I., additional, Herreman, A., additional, Kuypers, D., additional, Van Cleemput, J., additional, Nevens, F., additional, Dupont, L., additional, Uyttebroeck, A., additional, Pirenne, J., additional, De Wolf-Peeters, C., additional, Verhoef, G., additional, Brepoels, L., additional, and Gheysens, O., additional

Published
2012
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250. Nederland, fraude- en corruptieland?

Author

Huberts, L., Hulsebosch, H., Lasthuizen, K., Peeters, C., Huberts, L., Hulsebosch, H., Lasthuizen, K., and Peeters, C.

Published
2004

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