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4,274 results on '"Pedersen, Oluf"'

201. Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes

Author

Hindy, George, primary, Dornbos, Peter, additional, Chaffin, Mark D., additional, Liu, Dajiang J., additional, Wang, Minxian, additional, Selvaraj, Margaret Sunitha, additional, Zhang, David, additional, Park, Joseph, additional, Aguilar-Salinas, Carlos A., additional, Antonacci-Fulton, Lucinda, additional, Ardissino, Diego, additional, Arnett, Donna K., additional, Aslibekyan, Stella, additional, Atzmon, Gil, additional, Ballantyne, Christie M., additional, Barajas-Olmos, Francisco, additional, Barzilai, Nir, additional, Becker, Lewis C., additional, Bielak, Lawrence F., additional, Bis, Joshua C., additional, Blangero, John, additional, Boerwinkle, Eric, additional, Bonnycastle, Lori L., additional, Bottinger, Erwin, additional, Bowden, Donald W., additional, Bown, Matthew J., additional, Brody, Jennifer A., additional, Broome, Jai G., additional, Burtt, Noël P., additional, Cade, Brian E., additional, Centeno-Cruz, Federico, additional, Chan, Edmund, additional, Chang, Yi-Cheng, additional, Chen, Yii-Der I., additional, Cheng, Ching-Yu, additional, Choi, Won Jung, additional, Chowdhury, Rajiv, additional, Contreras-Cubas, Cecilia, additional, Córdova, Emilio J., additional, Correa, Adolfo, additional, Cupples, L. Adrienne, additional, Curran, Joanne E., additional, Danesh, John, additional, de Vries, Paul S., additional, DeFronzo, Ralph A., additional, Doddapaneni, Harsha, additional, Duggirala, Ravindranath, additional, Dutcher, Susan K., additional, Ellinor, Patrick T., additional, Emery, Leslie S., additional, Florez, Jose C., additional, Fornage, Myriam, additional, Freedman, Barry I., additional, Fuster, Valentin, additional, Garay-Sevilla, Ma. Eugenia, additional, García-Ortiz, Humberto, additional, Germer, Soren, additional, Gibbs, Richard A., additional, Gieger, Christian, additional, Glaser, Benjamin, additional, Gonzalez, Clicerio, additional, Gonzalez-Villalpando, Maria Elena, additional, Graff, Mariaelisa, additional, Graham, Sarah E., additional, Grarup, Niels, additional, Groop, Leif C., additional, Guo, Xiuqing, additional, Gupta, Namrata, additional, Han, Sohee, additional, Hanis, Craig L., additional, Hansen, Torben, additional, He, Jiang, additional, Heard-Costa, Nancy L., additional, Hung, Yi-Jen, additional, Hwang, Mi Yeong, additional, Irvin, Marguerite R., additional, Islas-Andrade, Sergio, additional, Jarvik, Gail P., additional, Kang, Hyun Min, additional, Kardia, Sharon L.R., additional, Kelly, Tanika, additional, Kenny, Eimear E., additional, Khan, Alyna T., additional, Kim, Bong-Jo, additional, Kim, Ryan W., additional, Kim, Young Jin, additional, Koistinen, Heikki A., additional, Kooperberg, Charles, additional, Kuusisto, Johanna, additional, Kwak, Soo Heon, additional, Laakso, Markku, additional, Lange, Leslie A., additional, Lee, Jiwon, additional, Lee, Juyoung, additional, Lee, Seonwook, additional, Lehman, Donna M., additional, Lemaitre, Rozenn N., additional, Linneberg, Allan, additional, Liu, Jianjun, additional, Loos, Ruth J.F., additional, Lubitz, Steven A., additional, Lyssenko, Valeriya, additional, Ma, Ronald C.W., additional, Martin, Lisa Warsinger, additional, Martínez-Hernández, Angélica, additional, Mathias, Rasika A., additional, McGarvey, Stephen T., additional, McPherson, Ruth, additional, Meigs, James B., additional, Meitinger, Thomas, additional, Melander, Olle, additional, Mendoza-Caamal, Elvia, additional, Metcalf, Ginger A., additional, Mi, Xuenan, additional, Mohlke, Karen L., additional, Montasser, May E., additional, Moon, Jee-Young, additional, Moreno-Macías, Hortensia, additional, Morrison, Alanna C., additional, Muzny, Donna M., additional, Nelson, Sarah C., additional, Nilsson, Peter M., additional, O’Connell, Jeffrey R., additional, Orho-Melander, Marju, additional, Orozco, Lorena, additional, Palmer, Colin N.A., additional, Palmer, Nicholette D., additional, Park, Cheol Joo, additional, Park, Kyong Soo, additional, Pedersen, Oluf, additional, Peralta, Juan M., additional, Peyser, Patricia A., additional, Post, Wendy S., additional, Preuss, Michael, additional, Psaty, Bruce M., additional, Qi, Qibin, additional, Rao, D.C., additional, Redline, Susan, additional, Reiner, Alexander P., additional, Revilla-Monsalve, Cristina, additional, Rich, Stephen S., additional, Samani, Nilesh, additional, Schunkert, Heribert, additional, Schurmann, Claudia, additional, Seo, Daekwan, additional, Seo, Jeong-Sun, additional, Sim, Xueling, additional, Sladek, Rob, additional, Small, Kerrin S., additional, So, Wing Yee, additional, Stilp, Adrienne M., additional, Tai, E. Shyong, additional, Tam, Claudia H.T., additional, Taylor, Kent D., additional, Teo, Yik Ying, additional, Thameem, Farook, additional, Tomlinson, Brian, additional, Tsai, Michael Y., additional, Tuomi, Tiinamaija, additional, Tuomilehto, Jaakko, additional, Tusié-Luna, Teresa, additional, Udler, Miriam S., additional, van Dam, Rob M., additional, Vasan, Ramachandran S., additional, Viaud Martinez, Karine A., additional, Wang, Fei Fei, additional, Wang, Xuzhi, additional, Watkins, Hugh, additional, Weeks, Daniel E., additional, Wilson, James G., additional, Witte, Daniel R., additional, Wong, Tien-Yin, additional, Yanek, Lisa R., additional, Kathiresan, Sekar, additional, Rader, Daniel J., additional, Rotter, Jerome I., additional, Boehnke, Michael, additional, McCarthy, Mark I., additional, Willer, Cristen J., additional, Natarajan, Pradeep, additional, Flannick, Jason A., additional, Khera, Amit V., additional, and Peloso, Gina M., additional

Published
2022
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202. Physical activity and sedentary behavior; mechanistic insights and role in disease prevention

Author

Hoed, Marcel den, primary, Wang, Zhe, additional, Emmerich, Andrew, additional, Pillon, Nicolas, additional, Moore, Timothy, additional, Hemerich, Daiane, additional, Cornelis, Marilyn, additional, Mazzaferro, Eugenia, additional, Broos, Siacia, additional, Ameur, Adam, additional, Bandinelli, Stefania, additional, Bis, Joshua, additional, Boehnke, Michael, additional, Bouchard, Claude, additional, Chasman, Daniel, additional, de Geus, Eco, additional, Deldicque, Louise, additional, Dörr, Marcus, additional, Evans, Michele, additional, Ferrucci, Luigi, additional, Fornage, Myriam, additional, Fox, Caroline, additional, Garland, Theodore, additional, Gyllensten, Ulf, additional, Hansen, Torben, additional, Hayward, Caroline, additional, Horta, Bernardo, additional, Hypponen, Elina, additional, Johnson, W. Craig, additional, Kardia, Sharon, additional, Kiemeney, Lambertus, additional, Laakso, Markku, additional, Langenberg, Claudia, additional, Lehtimäki, Terho, additional, Marchand, Loic Le, additional, Magnusson, Patrik, additional, Martin, Nicholas, additional, Melbye, Mads, additional, Metspalu, Andres, additional, Meyre, David, additional, North, Kari, additional, Ohlsson, Claes, additional, Oldehinkel, Albertine, additional, Orho-Melander, Marju, additional, Pare, Guillaume, additional, Park, Taesung, additional, Pedersen, Oluf, additional, Penninx, Brenda, additional, Pers, Tune, additional, Polasek, Ozren, additional, Prokopenko, Inga, additional, Rotimi, Charles, additional, Samani, Nilesh, additional, Sim, Xueling, additional, Smith, George Davey, additional, Snieder, Harold, additional, Sorensen, Thorkild, additional, Spector, Tim, additional, Timpson, Nicholas, additional, Dam, Rob van, additional, Velde, Nathalie van der, additional, Vollenweider, Peter, additional, Völzke, Henry, additional, Voortman, Trudy, additional, Waeber, Gerard, additional, Wareham, Nick, additional, Weir, David, additional, Wichmann, Erich, additional, Wilson, James, additional, Hevener, Andrea, additional, Krook, Anna, additional, Zierath, Juleen, additional, Thomis, Martine, additional, and Loos, Ruth, additional

Published
2021
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203. Recessive Genome-wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes

Author

O’Connor, Mark J., primary, Schroeder, Philip, primary, Huerta-Chagoya, Alicia, primary, Cortés-Sánchez, Paula, primary, Bonàs-Guarch, Silvía, primary, Guindo-Martínez, Marta, primary, Cole, Joanne B., primary, Kaur, Varinderpal, primary, Torrents, David, primary, Veerapen, Kumar, primary, Grarup, Niels, primary, Kurki, Mitja, primary, Rundsten, Carsten F., primary, Pedersen, Oluf, primary, Brandslund, Ivan, primary, Linneberg, Allan, primary, Hansen, Torben, primary, Leong, Aaron, primary, Florez, Jose C., primary, and Mercader, Josep M., primary

Published
2021
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204. Erratum:Role of fasting duration and weekday in incretin and glucose regulation

Author

Clemmensen, Kim K.B., Quist, Jonas S., Vistisen, Dorte, Witte, Daniel R., Jonsson, Anna, Pedersen, Oluf, Hansen, Torben, Holst, Jens J., Lauritzen, Torsten, Jørgensen, Marit E., Torekov, Signe, and Færch, Kristine

Abstract

The authors and journal apologise for errors in the above paper, which appeared in volume 9 part 4, pages 279-288. The errors relate to three values given in Table 2 on page 283. The value for Unadjusted upper 95% CI of 120 min plasma glucose should be 3.0, not 3.9, the value for Adjusted Estimate of Fasting plasma glucagon should be 0.0 not 0.3, and the value for Unadjusted Estimate of 30 min plasma GLP-1 should be -0.5 not -1.5. These errors do not affect the results or conclusions. The correct Table 2 is given in full below

Published
2021

205. A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

Author

Moltke, Ida, Grarup, Niels, Jorgensen, Marit E., Bjerregaard, Peter, Treebak, Jonas T., Fumagalli, Matteo, Korneliussen, Thorfinn S., Andersen, Marianne A., Nielsen, Thomas S., Krarup, Nikolaj T., Gjesing, Anette P., Zierath, Juleen R., Linneberg, Allan, Wu, Xueli, Sun, Guangqing, Jin, Xin, Aama, Jumana Al-, Wang, Jun, Borch-Johnsen, Knut, Pedersen, Oluf, Nielsen, Rasmus, Albrechtsen, Anders, and Hansen, Torben

Subjects
Genomics -- Research, Glucose metabolism -- Research, Type 2 diabetes -- Research -- Risk factors -- Patient outcomes -- Development and progression -- Complications and side effects, Muscles -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The Greenlandic population, a small and historically isolated founder population comprising about 57,000 inhabitants, has experienced a dramatic increase in type 2 diabetes (T2D) prevalence during the past 25 years (1). Motivated by this, we performed association mapping of T2D-related quantitative traits in up to 2,575 Greenlandic individuals without known diabetes. Using array-based genotyping and exome sequencing, we discovered a nonsense p.Arg684Ter variant (in which arginine is replaced by a termination codon) in the gene TBC1D4 with an allele frequency of 17%. Here we show that homozygous carriers of this variant have markedly higher concentrations of plasma glucose (β = 3.8 mmol [l.sup.-1], P = 2.5 x [10.sup.-35]) and serum insulin (β = 165 pmol [l.sup.-1], P = 1.5 x [10.sup.-20]) 2 hours after an oral glucose load compared with individuals with other genotypes (both non-carriers and heterozygous carriers). Furthermore, homozygous carriers have marginally lower concentrations of fasting plasma glucose (β = -0.18 mmol [l.sup.-1], P = 1.1 x [10.sup.-6]) and fasting serum insulin (β = -8.3 pmol [l.sup.-1], P = 0.0014), and their T2D risk is markedly increased (odds ratio (OR) = 10.3, P = 1.6 x [10.sup.-24]). Heterozygous carriers have a moderately higher plasma glucose concentration 2 hours after an oral glucose load than non-carriers (β = 0.43 mmol [l.sup.-1], P = 5.3 x [10.sup.-5]). Analyses of skeletal muscle biopsies showed lower messenger RNA and protein levels of the long isoform of TBC1D4, and lower muscle protein levels of the glucose transporter GLUT4, with increasing number of p.Arg684Ter alleles. These findings are concomitant with a severely decreased insulin-stimulated glucose uptake in muscle, leading to postprandial hyperglycaemia, impaired glucose tolerance and T2D. The observed effect sizes are several times larger than any previous findings in large-scale genome-wide association studies of these traits (2-4) and constitute further proof of the value of conducting genetic association studies outside the traditional setting of large homogeneous populations. .,A,AA 0.278 Intron AACA 0.167 Intron 0.389 Intron, Genetic association studies have traditionally been performed in large homogeneous populations. However, several studies have shown that it can be valuable to use founder populations (5), and there are similar [...]

Published
2014

208. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

Author

Koivula, Robert W., Heggie, Alison, Barnett, Anna, Cederberg, Henna, Hansen, Tue H., Koopman, Anitra D., Ridderstråle, Martin, Rutters, Femke, Vestergaard, Henrik, Gupta, Ramneek, Herrgård, Sanna, Heymans, Martijn W., Perry, Mandy H., Rauh, Simone, Siloaho, Maritta, Teare, Harriet J. A., Thorand, Barbara, Bell, Jimmy, Brunak, Søren, Frost, Gary, Jablonka, Bernd, Mari, Andrea, McDonald, Tim J., Dekker, Jacqueline M., Hansen, Torben, Hattersley, Andrew, Laakso, Markku, Pedersen, Oluf, Koivisto, Veikko, Ruetten, Hartmut, Walker, Mark, Pearson, Ewan, Franks, Paul W., and for the DIRECT Consortium

Published
2014
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212. Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

Author

Felix, Janine F., Bradfield, Jonathan P., Monnereau, Claire, van der Valk, Ralf J.P., Stergiakouli, Evie, Chesi, Alessandra, Gaillard, Romy, Feenstra, Bjarke, Thiering, Elisabeth, Kreiner-Møller, Eskil, Mahajan, Anubha, Pitkänen, Niina, Joro, Raimo, Cavadino, Alana, Huikari, Ville, Franks, Steve, Groen-Blokhuis, Maria M., Cousminer, Diana L., Marsh, Julie A., Lehtimäki, Terho, Curtin, John A., Vioque, Jesus, Ahluwalia, Tarunveer S., Myhre, Ronny, Price, Thomas S., Vilor-Tejedor, Natalia, Yengo, Loïc, Grarup, Niels, Ntalla, Ioanna, Ang, Wei, Atalay, Mustafa, Bisgaard, Hans, Blakemore, Alexandra I., Bonnefond, Amelie, Carstensen, Lisbeth, Eriksson, Johan, Flexeder, Claudia, Franke, Lude, Geller, Frank, Geserick, Mandy, Hartikainen, Anna-Liisa, Haworth, Claire M.A., Hirschhorn, Joel N., Hofman, Albert, Holm, Jens-Christian, Horikoshi, Momoko, Hottenga, Jouke Jan, Huang, Jinyan, Kadarmideen, Haja N., Kähönen, Mika, Kiess, Wieland, Lakka, Hanna-Maaria, Lakka, Timo A., Lewin, Alexandra M., Liang, Liming, Lyytikäinen, Leo-Pekka, Ma, Baoshan, Magnus, Per, McCormack, Shana E., McMahon, George, Mentch, Frank D., Middeldorp, Christel M., Murray, Clare S., Pahkala, Katja, Pers, Tune H., Pfäffle, Roland, Postma, Dirkje S., Power, Christine, Simpson, Angela, Sengpiel, Verena, Tiesler, Carla M. T., Torrent, Maties, Uitterlinden, André G., van Meurs, Joyce B., Vinding, Rebecca, Waage, Johannes, Wardle, Jane, Zeggini, Eleftheria, Zemel, Babette S., Dedoussis, George V., Pedersen, Oluf, Froguel, Philippe, Sunyer, Jordi, Plomin, Robert, Jacobsson, Bo, Hansen, Torben, Gonzalez, Juan R., Custovic, Adnan, Raitakari, Olli T., Pennell, Craig E., Widén, Elisabeth, Boomsma, Dorret I., Koppelman, Gerard H., Sebert, Sylvain, Järvelin, Marjo-Riitta, Hyppönen, Elina, McCarthy, Mark I., Lindi, Virpi, Harri, Niinikoski, Körner, Antje, Bønnelykke, Klaus, Heinrich, Joachim, Melbye, Mads, Rivadeneira, Fernando, Hakonarson, Hakon, Ring, Susan M., Smith, George Davey, Sørensen, Thorkild I.A., Timpson, Nicholas J., Grant, Struan F.A., Jaddoe, Vincent W.V., Kalkwarf, Heidi J., Lappe, Joan M., Gilsanz, Vicente, Oberfield, Sharon E., Shepherd, John A., Kelly, Andrea, and Zemel, Babette S.

Published
2016
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213. The gut microbiota in multiple sclerosis varies with disease activity.

Author

Thirion, Florence, Sellebjerg, Finn, Fan, Yong, Lyu, Liwei, Hansen, Tue H., Pons, Nicolas, Levenez, Florence, Quinquis, Benoit, Stankevic, Evelina, Søndergaard, Helle B., Dantoft, Thomas M., Poulsen, Casper S., Forslund, Sofia K., Vestergaard, Henrik, Hansen, Torben, Brix, Susanne, Oturai, Annette, Sørensen, Per Soelberg, Ehrlich, Stanislav D., and Pedersen, Oluf

Subjects
INTERFERON beta 1b, MULTIPLE sclerosis, NATALIZUMAB, GUT microbiome, SPINAL cord diseases, GENE expression profiling, SHOTGUN sequencing, ETIOLOGY of diseases
Abstract

Background: Multiple sclerosis is a chronic immune-mediated disease of the brain and spinal cord resulting in physical and cognitive impairment in young adults. It is hypothesized that a disrupted bacterial and viral gut microbiota is a part of the pathogenesis mediating disease impact through an altered gut microbiota-brain axis. The aim of this study is to explore the characteristics of gut microbiota in multiple sclerosis and to associate it with disease variables, as the etiology of the disease remains only partially known. Methods: Here, in a case-control setting involving 148 Danish cases with multiple sclerosis and 148 matched healthy control subjects, we performed shotgun sequencing of fecal microbial DNA and associated bacterial and viral microbiota findings with plasma cytokines, blood cell gene expression profiles, and disease activity. Results: We found 61 bacterial species that were differentially abundant when comparing all multiple sclerosis cases with healthy controls, among which 31 species were enriched in cases. A cluster of inflammation markers composed of blood leukocytes, CRP, and blood cell gene expression of IL17A and IL6 was positively associated with a cluster of multiple sclerosis-related species. Bacterial species that were more abundant in cases with disease-active treatment-naïve multiple sclerosis were positively linked to a group of plasma cytokines including IL-22, IL-17A, IFN-β, IL-33, and TNF-α. The bacterial species richness of treatment-naïve multiple sclerosis cases was associated with number of relapses over a follow-up period of 2 years. However, in non-disease-active cases, we identified two bacterial species, Faecalibacterium prausnitzii and Gordonibacter urolithinfaciens, whose absolute abundance was enriched. These bacteria are known to produce anti-inflammatory metabolites including butyrate and urolithin. In addition, cases with multiple sclerosis had a higher viral species diversity and a higher abundance of Caudovirales bacteriophages. Conclusions: Considerable aberrations are present in the gut microbiota of patients with multiple sclerosis that are directly associated with blood biomarkers of inflammation, and in treatment-naïve cases bacterial richness is positively associated with disease activity. Yet, the finding of two symbiotic bacterial species in non-disease-active cases that produce favorable immune-modulating compounds provides a rationale for testing these bacteria as adjunct therapeutics in future clinical trials. [ABSTRACT FROM AUTHOR]

Published
2023
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215. Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

Author

Goodrich, Julia K, Singer-Berk, Moriel, Son, Rachel, Sveden, Abigail, Wood, Jordan, England, Eleina, Cole, Joanne B, Weisburd, Ben, Watts, Nick, Caulkins, Lizz, Dornbos, Peter, Koesterer, Ryan, Zappala, Zachary, Zhang, Haichen, Maloney, Kristin A, Dahl, Andy, Aguilar-Salinas, Carlos A, Atzmon, Gil, Barajas-Olmos, Francisco, Barzilai, Nir, Blangero, John, Boerwinkle, Eric, Bonnycastle, Lori L, Bottinger, Erwin, Bowden, Donald W, Centeno-Cruz, Federico, Chambers, John C, Chami, Nathalie, Chan, Edmund, Chan, Juliana, Cheng, Ching-Yu, Cho, Yoon Shin, Contreras-Cubas, Cecilia, Córdova, Emilio, Correa, Adolfo, DeFronzo, Ralph A, Duggirala, Ravindranath, Dupuis, Josée, Garay-Sevilla, Ma Eugenia, García-Ortiz, Humberto, Gieger, Christian, Glaser, Benjamin, González-Villalpando, Clicerio, Gonzalez, Ma Elena, Grarup, Niels, Groop, Leif, Gross, Myron, Haiman, Christopher, Han, Sohee, Hanis, Craig L, Hansen, Torben, Heard-Costa, Nancy L, Henderson, Brian E, Hernandez, Juan Manuel Malacara, Hwang, Mi Yeong, Islas-Andrade, Sergio, Jørgensen, Marit E, Kang, Hyun Min, Kim, Bong-Jo, Kim, Young Jin, Koistinen, Heikki A, Kooner, Jaspal Singh, Kuusisto, Johanna, Kwak, Soo-Heon, Laakso, Markku, Lange, Leslie, Lee, Jong-Young, Lee, Juyoung, Lehman, Donna M, Linneberg, Allan, Liu, Jianjun, Loos, Ruth JF, Lyssenko, Valeriya, Ma, Ronald CW, Martínez-Hernández, Angélica, Meigs, James B, Meitinger, Thomas, Mendoza-Caamal, Elvia, Mohlke, Karen L, Morris, Andrew D, Morrison, Alanna C, Ng, Maggie CY, Nilsson, Peter M, O'Donnell, Christopher J, Orozco, Lorena, Palmer, Colin NA, Park, Kyong Soo, Post, Wendy S, Pedersen, Oluf, Preuss, Michael, Psaty, Bruce M, Reiner, Alexander P, Revilla-Monsalve, Cristina, Rich, Stephen S, Rotter, Jerome I, Saleheen, Danish, Schurmann, Claudia, Sim, Xueling, Sladek, Rob, and Small, Kerrin S

Subjects
Adult, Multifactorial Inheritance, Genotype, Prevention, Human Genome, Diabetes, Population, Biological Variation, Penetrance, Risk Assessment, Good Health and Well Being, Genetics, AMP-T2D-GENES Consortia, Diabetes Mellitus, 2.1 Biological and endogenous factors, Humans, Genetic Predisposition to Disease, Exome, Genetic Testing, Aetiology, Metabolic and endocrine, Type 2, Biomarkers, Dyslipidemias
Abstract

Hundreds of thousands of genetic variants have been reported to cause severe monogenic diseases, but the probability that a variant carrier develops the disease (termed penetrance) is unknown for virtually all of them. Additionally, the clinical utility of common polygenetic variation remains uncertain. Using exome sequencing from 77,184 adult individuals (38,618 multi-ancestral individuals from a type 2 diabetes case-control study and 38,566 participants from the UK Biobank, for whom genotype array data were also available), we apply clinical standard-of-care gene variant curation for eight monogenic metabolic conditions. Rare variants causing monogenic diabetes and dyslipidemias display effect sizes significantly larger than the top 1% of the corresponding polygenic scores. Nevertheless, penetrance estimates for monogenic variant carriers average 60% or lower for most conditions. We assess epidemiologic and genetic factors contributing to risk prediction in monogenic variant carriers, demonstrating that inclusion of polygenic variation significantly improves biomarker estimation for two monogenic dyslipidemias.

Published
2021

216. Role of fasting duration and weekday in incretin and glucose regulation

Author

Clemmensen, Kim K B, primary, Quist, Jonas S, additional, Vistisen, Dorte, additional, Witte, Daniel R, additional, Jonsson, Anna, additional, Pedersen, Oluf, additional, Hansen, Torben, additional, Holst, Jens J, additional, Lauritzen, Torsten, additional, Jorgensen, Marit E, additional, Torekov, Signe, additional, and Faerch, Kristine, additional

Published
2021
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217. Non-linear interaction between physical activity and polygenic risk score of body mass index in Danish and Russian populations

Author

Borisevich, Dmitrii, primary, Schnurr, Theresia M., additional, Engelbrechtsen, Line, additional, Rakitko, Alexander, additional, Ängquist, Lars, additional, Ilinsky, Valery, additional, Aadahl, Mette, additional, Grarup, Niels, additional, Pedersen, Oluf, additional, Sørensen, Thorkild I. A., additional, and Hansen, Torben, additional

Published
2021
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218. Inferring causal pathways between metabolic processes and liver fat accumulation: an IMI DIRECT study

Author

Atabaki-Pasdar, Naeimeh, primary, Pomares-Millan, Hugo, additional, Koivula, Robert W, additional, Tura, Andrea, additional, Brown, Andrew, additional, Viñuela, Ana, additional, Agudelo, Leandro, additional, Coral, Daniel, additional, van Oort, Sabine, additional, Allin, Kristine, additional, Chabanova, Elizaveta, additional, Cederberg, Henna, additional, De Masi, Federico, additional, Elders, Petra, additional, Tajes, Juan Fernandez, additional, Forgie, Ian M, additional, Hansen, Tue H, additional, Heggie, Alison, additional, Jones, Angus, additional, Kokkola, Tarja, additional, Mahajan, Anubha, additional, McDonald, Timothy J, additional, McEvoy, Donna, additional, Tsirigos, Konstantinos, additional, Teare, Harriet, additional, Vangipurapu, Jagadish, additional, Vestergaard, Henrik, additional, Adamski, Jerzy, additional, Beulens, Joline WJ, additional, Brunak, Søren, additional, Dermitzakis, Emmanouil, additional, Hansen, Torben, additional, Hattersley, Andrew T, additional, Laakso, Markku, additional, Pedersen, Oluf, additional, Ridderstråle, Martin, additional, Ruetten, Hartmut, additional, Rutters, Femke, additional, Schwenk, Jochen M, additional, Walker, Mark, additional, Giordano, Giuseppe N, additional, Ohlsson, Mattias, additional, Gupta, Ramneek, additional, Mari, Andrea, additional, McCarthy, Mark I, additional, Thomas, E Louise, additional, Bell, Jimmy D, additional, Pavo, Imre, additional, Pearson, Ewan R, additional, and Franks, Paul W, additional

Published
2021
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219. Alteration of Gut Microbiome in Patients With Schizophrenia Indicates Links Between Bacterial Tyrosine Biosynthesis and Cognitive Dysfunction

Author

Thirion, Florence, Speyer, Helene, Hansen, Tue Haldor, Nielsen, Trine, Fan, Yong, Le Chatelier, Emmanuelle, Fromentin, Sébastien, Berland, Magali, Plaza Oñate, Florian, Pons, Nicolas, Galleron, Nathalie, Levenez, Florence, Markó, Lajos, Birkner, Till, Jørgensen, Torben, Forslund, Sofia K., Vestergaard, Henrik, Hansen, Torben, Nordentoft, Merete, Mors, Ole, Benros, Michael E., Pedersen, Oluf, and Ehrlich, Stanislav D.

Abstract

Schizophrenia (SCZ) is a heterogeneous neuropsychiatric disorder for which current treatment has insufficient efficacy and severe adverse effects. The modifiable gut microbiome might be a potential target for intervention to improve neurobiological functions through the gut-microbiome-brain axis.

Published
2023
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221. Rare genetic variants previously associated with congenital forms of long QT syndrome have little or no effect on the QT interval

Author

Ghouse, Jonas, Have, Christian Theil, Weeke, Peter, Bille Nielsen, Jonas, Ahlberg, Gustav, Balslev-Harder, Marie, Appel, Emil Vincent, Skaaby, Tea, Olesen, Søren-Peter, Grarup, Niels, Linneberg, Allan, Pedersen, Oluf, Haunsø, Stig, Hastrup Svendsen, Jesper, Hansen, Torben, Kanters, Jørgen Kim, and Salling Olesen, Morten

Published
2015
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222. HUMAN GENETICS: Greenlandic Inuit show genetic signatures of diet and climate adaptation

Author

Fumagalli, Matteo, Moltke, Ida, Grarup, Niels, Racimo, Fernando, Bjerregaard, Peter, Jørgensen, Marit E., Korneliussen, Thorfinn S., Gerbault, Pascale, Skotte, Line, Linneberg, Allan, Christensen, Cramer, Brandslund, Ivan, Jørgensen, Torben, Huerta-Sánchez, Emilia, Schmidt, Erik B., Pedersen, Oluf, Hansen, Torben, Albrechtsen, Anders, and Nielsen, Rasmus

Published
2015
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225. Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood

Author

Rönn, Tina, Volkov, Petr, Gillberg, Linn, Kokosar, Milana, Perfilyev, Alexander, Jacobsen, Anna Louisa, Jørgensen, Sine W., Brøns, Charlotte, Jansson, Per-Anders, Eriksson, Karl-Fredrik, Pedersen, Oluf, Hansen, Torben, Groop, Leif, Stener-Victorin, Elisabet, Vaag, Allan, Nilsson, Emma, and Ling, Charlotte

Published
2015
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227. Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion

Author

Yaghootkar, Hanieh, Stancáková, Alena, Freathy, Rachel M., Vangipurapu, Jagadish, Weedon, Michael N., Xie, Weijia, Wood, Andrew R., Ferrannini, Ele, Mari, Andrea, Ring, Susan M., Lawlor, Debbie A., Davey Smith, George, Jørgensen, Torben, Hansen, Torben, Pedersen, Oluf, Steinthorsdottir, Valgerdur, Gubjartsson, Daniel F., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Stefansson, Kari, Hattersley, Andrew T., Walker, Mark, Morris, Andrew D., McCarthy, Mark I., Palmer, Colin N.A., Laakso, Markku, and Frayling, Timothy M.

Published
2015
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230. A glycogene mutation map for discovery of diseases of glycosylation

Author

Hansen, Lars, Lind-Thomsen, Allan, Joshi, Hiren J, Pedersen, Nis Borbye, Have, Christian Theil, Kong, Yun, Wang, Shengjun, Sparso, Thomas, Grarup, Niels, Vester-Christensen, Malene Bech, Schjoldager, Katrine, Freeze, Hudson H, Hansen, Torben, Pedersen, Oluf, Henrissat, Bernard, Mandel, Ulla, Clausen, Henrik, Wandall, Hans H, and Bennett, Eric P

Published
2015
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231. Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants1-5

Author

Dashti, Hassan S, Follis, Jack L, Smith, Caren E, Tanaka, Toshiko, Cade, Brian E, Gottlieb, Daniel J, Hruby, Adela, Jacques, Paul F, Lamon-Fava, Stefania, Richardson, Kris, Saxena, Richa, Scheer, Frank AJL, Kovanen, Leena, Bartz, Traci M, Perälä, Mia-Maria, Jonsson, Anna, Frazier-Wood, Alexis C, Kalafati, Ioanna-Panagiota, Mikkilä, Vera, Partonen, Timo, Lemaitre, Rozenn N, Lahti, Jari, Hernandez, Dena G, Toft, Ulla, Johnson, Craig W, Kanoni, Stavroula, Raitakari, Olli T, Perola, Markus, Psaty, Bruce M, Ferrucci, Luigi, Grarup, Niels, Highland, Heather M, Rallidis, Loukianos, Kähönen, Mika, Havulinna, Aki S, Siscovick, David S, Räikkönen, Katri, Jørgensen, Torben, Rotter, Jerome I, Deloukas, Panos, Viikari, Jorma SA, Mozaffarian, Dariush, Linneberg, Allan, Seppälä, Ilkka, Hansen, Torben, Salomaa, Veikko, Gharib, Sina A, Eriksson, Johan G, Bandinelli, Stefania, Pedersen, Oluf, Rich, Stephen S, Dedoussis, George, Lehtimäki, Terho, and Ordovás, José M

Published
2015
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232. FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

Author

Qi, Qibin, Kilpeläinen, Tuomas O., Downer, Mary K., Tanaka, Toshiko, Smith, Caren E., Sluijs, Ivonne, Sonestedt, Emily, Chu, Audrey Y., Renström, Frida, Lin, Xiaochen, Ängquist, Lars H., Huang, Jinyan, Liu, Zhonghua, Li, Yanping, Asif Ali, Muhammad, Xu, Min, Ahluwalia, Tarunveer Singh, Boer, Jolanda M.A., Chen, Peng, Daimon, Makoto, Eriksson, Johan, Perola, Markus, Friedlander, Yechiel, Gao, Yu-Tang, Heppe, Denise H.M., Holloway, John W., Houston, Denise K., Kanoni, Stavroula, Kim, Yu-Mi, Laaksonen, Maarit A., Jääskeläinen, Tiina, Lee, Nanette R., Lehtimäki, Terho, Lemaitre, Rozenn N., Lu, Wei, Luben, Robert N., Manichaikul, Ani, Männistö, Satu, Marques-Vidal, Pedro, Monda, Keri L., Ngwa, Julius S., Perusse, Louis, van Rooij, Frank J.A., Xiang, Yong-Bing, Wen, Wanqing, Wojczynski, Mary K, Zhu, Jingwen, Borecki, Ingrid B., Bouchard, Claude, Cai, Qiuyin, Cooper, Cyrus, Dedoussis, George V., Deloukas, Panos, Ferrucci, Luigi, Forouhi, Nita G., Hansen, Torben, Christiansen, Lene, Hofman, Albert, Johansson, Ingegerd, Jørgensen, Torben, Karasawa, Shigeru, Khaw, Kay-Tee, Kim, Mi-Kyung, Kristiansson, Kati, Li, Huaixing, Lin, Xu, Liu, Yongmei, Lohman, Kurt K., Long, Jirong, Mikkilä, Vera, Mozaffarian, Dariush, North, Kari, Pedersen, Oluf, Raitakari, Olli, Rissanen, Harri, Tuomilehto, Jaakko, van der Schouw, Yvonne T., Uitterlinden, André G., Zillikens, M. Carola, Franco, Oscar H., Shyong Tai, E., Ou Shu, Xiao, Siscovick, David S., Toft, Ulla, Verschuren, W.M. Monique, Vollenweider, Peter, Wareham, Nicholas J., Witteman, Jacqueline C.M., Zheng, Wei, Ridker, Paul M., Kang, Jae H., Liang, Liming, Jensen, Majken K., Curhan, Gary C., Pasquale, Louis R., Hunter, David J., Mohlke, Karen L., Uusitupa, Matti, Cupples, L. Adrienne, Rankinen, Tuomo, Orho-Melander, Marju, Wang, Tao, Chasman, Daniel I., Franks, Paul W., Sørensen, Thorkild I.A., Hu, Frank B., Loos, Ruth J. F., Nettleton, Jennifer A., and Qi, Lu

Published
2014
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233. Richness of human gut microbiome correlates with metabolic markers

Author

Le Chatelier, Emmanuelle, Nielsen, Trine, Qin, Junjie, Prifti, Edi, Hildebrand, Falk, Falony, Gwen, Almeida, Mathieu, Arumugam, Manimozhiyan, Batto, Jean-Michel, Kennedy, Sean, Leonard, Pierre, Li, Junhua, Burgdorf, Kristoffer, Grarup, Niels, Jørgensen, Torben, Brandslund, Ivan, Nielsen, Henrik Bjørn, Juncker, Agnieszka S., Bertalan, Marcelo, Levenez, Florence, Pons, Nicolas, Rasmussen, Simon, Sunagawa, Shinichi, Tap, Julien, Tims, Sebastian, Zoetendal, Erwin G., Brunak, Søren, Clément, Karine, Doré, Joël, Kleerebezem, Michiel, Kristiansen, Karsten, Renault, Pierre, Sicheritz-Ponten, Thomas, de Vos, Willem M., Zucker, Jean-Daniel, Raes, Jeroen, Hansen, Torben, Bork, Peer, Wang, Jun, Ehrlich, S. Dusko, and Pedersen, Oluf

Published
2013
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235. FGL1 as a modulator of plasma D‐dimer levels: Exome‐wide marker analysis of plasma tPA, PAI‐1, and D‐dimer

Author

Thibord, Florian, primary, Song, Ci, additional, Pattee, Jack, additional, Rodriguez, Benjamin A.T., additional, Chen, Ming‐Huei, additional, O’Donnell, Christopher J., additional, Kleber, Marcus E., additional, Delgado, Graciela E., additional, Guo, Xiuqing, additional, Yao, Jie, additional, Taylor, Kent D., additional, Ozel, Ayse Bilge, additional, Brody, Jennifer A., additional, McKnight, Barbara, additional, Gyorgy, Beata, additional, Simonsick, Eleanor, additional, Leonard, Hampton L., additional, Carrasquilla, Germán D., additional, Guindo‐Martinez, Marta, additional, Silveira, Angela, additional, Temprano‐Sagrera, Gerard, additional, Yanek, Lisa R., additional, Becker, Diane M., additional, Mathias, Rasika A., additional, Becker, Lewis C., additional, Raffield, Laura M., additional, Kilpeläinen, Tuomas O., additional, Grarup, Niels, additional, Pedersen, Oluf, additional, Hansen, Torben, additional, Linneberg, Allan, additional, Hamsten, Anders, additional, Watkins, Hugh, additional, Sabater‐Lleal, Maria, additional, Nalls, Mike A., additional, Trégouët, David‐Alexandre, additional, Morange, Pierre‐Emmanuel, additional, Psaty, Bruce M., additional, Tracy, Russel P., additional, Smith, Nicholas L., additional, Desch, Karl C., additional, Cushman, Mary, additional, Rotter, Jerome I., additional, de Vries, Paul S., additional, Pankratz, Nathan D., additional, Folsom, Aaron R., additional, Morrison, Alanna C., additional, März, Winfried, additional, Tang, Weihong, additional, and Johnson, Andrew D., additional

Published
2021
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236. Genome-Wide Association Meta-Analysis Using a Recessive Model Illuminates Genetic Architecture of Type 2 Diabetes

Author

O’Connor, Mark J., primary, Huerta-Chagoya, Alicia, additional, Cortés-Sánchez, Paula, additional, Bonàs-Guarch, Silvía, additional, Guindo-Martínez, Marta, additional, Cole, Joanne B., additional, Torrents, David, additional, Veerapen, Kumar, additional, Grarup, Niels, additional, Kurki, Mitja, additional, Rundsten, Carsten F., additional, Pedersen, Oluf, additional, Brandslund, Ivan, additional, Linneberg, Allan, additional, Hansen, Torben, additional, Leong, Aaron, additional, Florez, Jose C., additional, and Mercader, Josep M., additional

Published
2021
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237. Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-hour OGTT: An IMI DIRECT Study

Author

Tura, Andrea, primary, Grespan, Eleonora, primary, Göbl, Christian S., primary, Koivula, Robert W., primary, Franks, Paul W., primary, Pearson, Ewan R., primary, Walker, Mark, primary, Forgie, Ian M., primary, Giordano, Giuseppe N., primary, Pavo, Imre, primary, Ruetten, Hartmut, primary, Dermitzakis, Emmanouil T., primary, McCarthy, Mark I., primary, Pedersen, Oluf, primary, Schwenk, Jochen M., primary, Adamski, Jerzy, primary, Masi, Federico De, primary, Tsirigos, Konstantinos D., primary, Brunak, Søren, primary, Viñuela, Ana, primary, Mahajan, Anubha, primary, McDonald, Timothy J., primary, Kokkola, Tarja, primary, Vangipurapu, Jagadish, primary, Cederberg, Henna, primary, Laakso, Markku, primary, Rutters, Femke, primary, Elders, Petra J.M., primary, Koopman, Anitra D.M., primary, Beulens, Joline W., primary, Ridderstråle, Martin, primary, Hansen, Tue H., primary, Allin, Kristine H., primary, Hansen, Torben, primary, Vestergaard, Henrik, primary, Mari, Andrea, primary, and Consortium, IMI DIRECT, primary

Published
2021
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238. Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species

Author

Petersen, Anders Ø, primary, Julienne, Hanna, additional, Hyötyläinen, Tuulia, additional, Sen, Partho, additional, Fan, Yong, additional, Pedersen, Helle Krogh, additional, Jäntti, Sirkku, additional, Hansen, Tue H., additional, Nielsen, Trine, additional, Jørgensen, Torben, additional, Hansen, Torben, additional, Myers, Pernille Neve, additional, Nielsen, H. Bjørn, additional, Ehrlich, S. Dusko, additional, Orešič, Matej, additional, and Pedersen, Oluf, additional

Published
2021
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240. Authors' reply to Kahn's comment

Author

Møller, Grith, primary, Ritz, Christian, additional, Kjølbæk, Louise, additional, Vuholm, Stine, additional, Korndal, Sanne K., additional, Larsen, Thomas M., additional, Pedersen, Oluf, additional, Saris, Wim, additional, Astrup, Arne, additional, Lauritzen, Lotte, additional, Kristensen, Mette, additional, and Lind, Mads V., additional

Published
2021
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241. Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Author

Sveidahl Johansen, Olivia, primary, Ma, Tao, additional, Hansen, Jakob Bondo, additional, Markussen, Lasse Kruse, additional, Schreiber, Renate, additional, Reverte-Salisa, Laia, additional, Dong, Hua, additional, Christensen, Dan Ploug, additional, Sun, Wenfei, additional, Gnad, Thorsten, additional, Karavaeva, Iuliia, additional, Nielsen, Thomas Svava, additional, Kooijman, Sander, additional, Cero, Cheryl, additional, Dmytriyeva, Oksana, additional, Shen, Yachen, additional, Razzoli, Maria, additional, O’Brien, Shannon L., additional, Kuipers, Eline N., additional, Nielsen, Carsten Haagen, additional, Orchard, William, additional, Willemsen, Nienke, additional, Jespersen, Naja Zenius, additional, Lundh, Morten, additional, Sustarsic, Elahu Gosney, additional, Hallgren, Cecilie Mørch, additional, Frost, Mikkel, additional, McGonigle, Seth, additional, Isidor, Marie Sophie, additional, Broholm, Christa, additional, Pedersen, Oluf, additional, Hansen, Jacob Bo, additional, Grarup, Niels, additional, Hansen, Torben, additional, Kjær, Andreas, additional, Granneman, James G., additional, Babu, M. Madan, additional, Calebiro, Davide, additional, Nielsen, Søren, additional, Rydén, Mikael, additional, Soccio, Raymond, additional, Rensen, Patrick C.N., additional, Treebak, Jonas Thue, additional, Schwartz, Thue Walter, additional, Emanuelli, Brice, additional, Bartolomucci, Alessandro, additional, Pfeifer, Alexander, additional, Zechner, Rudolf, additional, Scheele, Camilla, additional, Mandrup, Susanne, additional, and Gerhart-Hines, Zachary, additional

Published
2021
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242. Additional file 2 of Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test

Author

Jonsson, Anna, Stinson, Sara E., Torekov, Signe S., Clausen, Tine D., Færch, Kristine, Kelstrup, Louise, Grarup, Niels, Mathiesen, Elisabeth R., Damm, Peter, Witte, Daniel R., Jørgensen, Marit E., Pedersen, Oluf, Holst, Jens Juul, and Hansen, Torben

Abstract

Additional file 2: Figure S1. Title of data: QQ-plot of selected variants previously reported to associate with increased risk of type 2 diabetes. Description of data: The figure shows the observed vs. the expected P-values of the selected variants for fasting glucagon (A), 30 min glucagon (B), 120 min glucagon (C), decremental area under the curve (dAUC) 0-30 minutes of glucagon (D) and dAUC 0-120 minutes of glucagon (E) during the OGTT. There was no obvious excess of genetic variants, previously associated with type 2 diabetes, associating with circulating glucagon during OGTT.

Published
2021
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243. Additional file 3 of Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark

Author

Nishal Kumar Pinna, Anjana, Ranjit Mohan, Saxena, Shruti, Anirban Dutta, Visvanathan Gnanaprakash, Gnanavadivel Rameshkumar, Sukumaran Aswath, Srividhya Raghavan, Coimbatore Subramanian Shanthi Rani, Venkatesan Radha, Muthuswamy Balasubramanyam, Pant, Archana, Nielsen, Trine, Jørgensen, Torben, Færch, Kristine, Alireza Kashani, Silva, Maria Camila Alvarez, Vestergaard, Henrik, Hansen, Tue Haldor, Hansen, Torben, Manimozhiyan Arumugam, Gopinath Balakrish Nair, Bhabatosh Das, Pedersen, Oluf, Viswanathan Mohan, and Mande, Sharmila Shekhar

Subjects
carbohydrates (lipids), urogenital system, parasitic diseases, food and beverages, lipids (amino acids, peptides, and proteins)
Abstract

Additional file 3: Table S2. Biochemical parameters measured in Danish and Indian cohorts. Comparison of additional biochemical parameters measured in Danish and Indian cohorts.

Published
2021
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244. Additional file 4 of Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark

Author

Nishal Kumar Pinna, Anjana, Ranjit Mohan, Saxena, Shruti, Anirban Dutta, Visvanathan Gnanaprakash, Gnanavadivel Rameshkumar, Sukumaran Aswath, Srividhya Raghavan, Coimbatore Subramanian Shanthi Rani, Venkatesan Radha, Muthuswamy Balasubramanyam, Pant, Archana, Nielsen, Trine, Jørgensen, Torben, Færch, Kristine, Alireza Kashani, Silva, Maria Camila Alvarez, Vestergaard, Henrik, Hansen, Tue Haldor, Hansen, Torben, Manimozhiyan Arumugam, Gopinath Balakrish Nair, Bhabatosh Das, Pedersen, Oluf, Viswanathan Mohan, and Mande, Sharmila Shekhar

Abstract

Additional file 4: Table S3. Country effect on level of inflammatory biomarkers. Country effect on level of inflammatory biomarkers estimated as differences (%) in means (IN relative to DK) derived from linear mixed models adjusted for HbA1c values. Significant effects after BH correction (padj

Published
2021
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245. Additional file 2 of Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India

Author

Alvarez-Silva, Camila, Alireza Kashani, Hansen, Tue Haldor, Nishal Kumar Pinna, Anjana, Ranjit Mohan, Anirban Dutta, Saxena, Shruti, Støy, Julie, Kampmann, Ulla, Nielsen, Trine, Jørgensen, Torben, Visvanathan Gnanaprakash, Rameshkumar Gnanavadivel, Aswath Sukumaran, Coimbatore Subramanian Shanthi Rani, Færch, Kristine, Venkatesan Radha, Muthuswamy Balasubramanyam, Gopinath Balakrish Nair, Bhabatosh Das, Vestergaard, Henrik, Hansen, Torben, Mande, Sharmila Shekhar, Viswanathan Mohan, Manimozhiyan Arumugam, and Pedersen, Oluf

Abstract

Additional file 2 Eleven supporting Figures S1-S11. A figure caption for each is given within the file (Format: PDF).

Published
2021
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246. The power of genetic diversity in genome-wide association studies of lipids

Author

Graham, Sarah E. Clarke, Shoa L. Wu, Kuan-Han H. Kanoni, Stavroula Zajac, Greg J. M. Ramdas, Shweta Surakka, Ida and Ntalla, Ioanna Vedantam, Sailaja Winkler, Thomas W. Locke, Adam E. Marouli, Eirini Hwang, Mi Yeong Han, Sohee and Narita, Akira Choudhury, Ananyo Bentley, Amy R. Ekoru, Kenneth Verma, Anurag Trivedi, Bhavi Martin, Hilary C. and Hunt, Karen A. Hui, Qin Klarin, Derek Zhu, Xiang and Thorleifsson, Gudmar Helgadottir, Anna Gudbjartsson, Daniel F. and Holm, Hilma Olafsson, Isleifur Akiyama, Masato Sakaue, Saori Terao, Chikashi Kanai, Masahiro Zhou, Wei and Brumpton, Ben M. Rasheed, Humaira Ruotsalainen, Sanni E. and Havulinna, Aki S. Veturi, Yogasudha Feng, QiPing Rosenthal, Elisabeth A. Lingren, Todd Pacheco, Jennifer Allen and Pendergrass, Sarah A. Haessler, Jeffrey Giulianini, Franco and Bradford, Yuki Miller, Jason E. Campbell, Archie Lin, Kuang and Millwood, Iona Y. Hindy, George Rasheed, Asif Faul, Jessica D. Zhao, Wei Weir, David R. Turman, Constance and Huang, Hongyan Graff, Mariaelisa Mahajan, Anubha Brown, Michael R. Zhang, Weihua Yu, Ketian Schmidt, Ellen M. and Pandit, Anita Gustafsson, Stefan Yin, Xianyong Luan, Jian'an and Zhao, Jing-Hua Matsuda, Fumihiko Jang, Hye-Mi Yoon, Kyungheon Medina-Gomez, Carolina Pitsillides, Achilleas and Hottenga, Jouke Jan Willemsen, Gonneke Wood, Andrew R. Ji, Yingji Gao, Zishan Haworth, Simon Mitchell, Ruth E. and Chai, Jin Fang Aadahl, Mette Yao, Jie Manichaikul, Ani and Warren, Helen R. Ramirez, Julia Bork-Jensen, Jette Karhus, Line L. Goel, Anuj Sabater-Lleal, Maria Noordam, Raymond and Sidore, Carlo Fiorillo, Edoardo McDaid, Aaron F. and Marques-Vidal, Pedro Wielscher, Matthias Trompet, Stella and Sattar, Naveed Mollehave, Line T. Thuesen, Betina H. Munz, Matthias Zeng, Lingyao Huang, Jianfeng Yang, Bin Poveda, Alaitz Kurbasic, Azra Lamina, Claudia Forer, Lukas and Scholz, Markus Galesloot, Tessel E. Bradfield, Jonathan P. and Daw, E. Warwick Zmuda, Joseph M. Mitchell, Jonathan S. and Fuchsberger, Christian Christensen, Henry Brody, Jennifer A. and Feitosa, Mary F. Wojczynski, Mary K. Preuss, Michael and Mangino, Massimo Christofidou, Paraskevi Verweij, Niek and Benjamins, Jan W. Engmann, Jorgen Kember, Rachel L. Slieker, Roderick C. Lo, Ken Sin Zilhao, Nuno R. Phuong Le and Kleber, Marcus E. Delgado, Graciela E. Huo, Shaofeng Ikeda, Daisuke D. Iha, Hiroyuki Yang, Jian Liu, Jun Leonard, Hampton L. Marten, Jonathan Schmidt, Borge Arendt, Marina and Smyth, Laura J. Canadas-Garre, Marisa Wang, Chaolong and Nakatochi, Masahiro Wong, Andrew Hutri-Kahonen, Nina Sim, Xueling Xia, Rui Huerta-Chagoya, Alicia Fernandez-Lopez, Juan Carlos Lyssenko, Valeriya Ahmed, Meraj Jackson, Anne U. and Irvin, Marguerite R. Oldmeadow, Christopher Kim, Han-Na and Ryu, Seungho Timmers, Paul R. H. J. Arbeeva, Liubov Dorajoo, Rajkumar Lange, Leslie A. Chai, Xiaoran Prasad, Gauri and Lores-Motta, Laura Pauper, Marc Long, Jirong Li, Xiaohui and Theusch, Elizabeth Takeuchi, Fumihiko Spracklen, Cassandra N. and Loukola, Anu Bollepalli, Sailalitha Warner, Sophie C. and Wang, Ya Xing Wei, Wen B. Nutile, Teresa Ruggiero, Daniela and Sung, Yun Ju Hung, Yi-Jen Chen, Shufeng Liu, Fangchao and Yang, Jingyun Kentistou, Katherine A. Gorski, Mathias and Brumat, Marco Meidtner, Karina Bielak, Lawrence F. Smith, Jennifer A. Hebbar, Prashantha Farmaki, Aliki-Eleni Hofer, Edith Lin, Maoxuan Xue, Chao Zhang, Jifeng Concas, Maria Pina Vaccargiu, Simona van der Most, Peter J. Pitkanen, Niina Cade, Brian E. Lee, Jiwon van Der Laan, Sander W. and Chitrala, Kumaraswamy Naidu Weiss, Stefan Zimmermann, Martina E. and Lee, Jong Young Choi, Hyeok Sun Nethander, Maria and Freitag-Wolf, Sandra Southam, Lorraine Rayner, Nigel W. and Wang, Carol A. Lin, Shih-Yi Wang, Jun-Sing Couture, Christian Lyytikainen, Leo-Pekka Nikus, Kjell and Cuellar-Partida, Gabriel Vestergaard, Henrik Hildalgo, Bertha and Giannakopoulou, Olga Cai, Qiuyin Obura, Morgan O. van Setten, Jessica Li, Xiaoyin Schwander, Karen Terzikhan, Natalie Shin, Jae Hun Jackson, Rebecca D. Reiner, Alexander P. Martin, Lisa Warsinger Chen, Zhengming Li, Liming and Highland, Heather M. Young, Kristin L. Kawaguchi, Takahisa and Thiery, Joachim Bis, Joshua C. Nadkarni, Girish N. Launer, Lenore J. Li, Huaixing Nalls, Mike A. Raitakari, Olli T. and Ichihara, Sahoko Wild, Sarah H. Nelson, Christopher P. and Campbell, Harry Jager, Susanne Nabika, Toru Al-Mulla, Fahd and Niinikoski, Harri Braund, Peter S. Kolcic, Ivana Kovacs, Peter Giardoglou, Tota Katsuya, Tomohiro Bhatti, Fatima and de Kleijn, Dominique de Borst, Gert J. Kim, Eung Kweon and Adams, Hieab H. H. Ikram, M. Arfan Zhu, Xiaofeng Asselbergs, Folkert W. Kraaijeveld, Adriaan O. Beulens, Joline W. J. and Shu, Xiao-Ou Rallidis, Loukianos S. Pedersen, Oluf Hansen, Torben Mitchell, Paul Hewitt, Alex W. Kahonen, Mika and Perusse, Louis Bouchard, Claude Tonjes, Anke Chen, Yii-Der Ida Pennell, Craig E. Mori, Trevor A. Lieb, Wolfgang and Franke, Andre Ohlsson, Claes Mellstrom, Dan Cho, Yoon Shin and Lee, Hyejin Yuan, Jian-Min Koh, Woon-Puay Rhee, Sang Youl Woo, Jeong-Taek Heid, Iris M. Stark, Klaus J. and Volzke, Henry Homuth, Georg Evans, Michele K. Zonderman, Alan B. Polasek, Ozren Pasterkamp, Gerard Hoefer, Imo E. and Redline, Susan Pahkala, Katja Oldehinkel, Albertine J. and Snieder, Harold Biino, Ginevra Schmidt, Reinhold Schmidt, Helena Chen, Y. Eugene Bandinelli, Stefania Dedoussis, George Thanaraj, Thangavel Alphonse Kardia, Sharon L. R. and Kato, Norihiro Schulze, Matthias B. Girotto, Giorgia Jung, Bettina Boger, Carsten A. Joshi, Peter K. Bennett, David A. and De Jager, Philip L. Lu, Xiangfeng Mamakou, Vasiliki and Brown, Morris Caulfield, Mark J. Munroe, Patricia B. Guo, Xiuqing Ciullo, Marina Jonas, Jost B. Samani, Nilesh J. and Kaprio, Jaakko Pajukanta, Paivi Adair, Linda S. Bechayda, Sonny Augustin de Silva, H. Janaka Wickremasinghe, Ananda R. and Krauss, Ronald M. Wu, Jer-Yuarn Zheng, Wei den Hollander, I, Anneke Bharadwaj, Dwaipayan Correa, Adolfo Wilson, James G. and Lind, Lars Heng, Chew-Kiat Nelson, Amanda E. Golightly, Yvonne M. Wilson, James F. Penninx, Brenda Kim, Hyung-Lae and Attia, John Scott, Rodney J. Rao, D. C. Arnett, Donna K. and Walker, Mark Koistinen, Heikki A. Chandak, Giriraj R. and Yajnik, Chittaranjan S. Mercader, Josep M. Tusie-Luna, Teresa and Aguilar-Salinas, Carlos A. Villalpando, Clicerio Gonzalez and Orozco, Lorena Fornage, Myriam Tai, E. Shyong van Dam, Rob M. Lehtimaki, Terho Chaturvedi, Nish Yokota, Mitsuhiro and Liu, Jianjun Reilly, Dermot F. McKnight, Amy Jayne Kee, Frank Jockel, Karl-Heinz McCarthy, I, Mark Palmer, Colin N. A. Vitart, Veronique Hayward, Caroline Simonsick, Eleanor and van Duijn, Cornelia M. Lu, Fan Qu, Jia Hishigaki, Haretsugu Lin, Xu Marz, Winfried Parra, Esteban J. Cruz, Miguel Gudnason, Vilmundur Tardif, Jean-Claude Lettre, Guillaume `t Hart, Leen M. Elders, Petra J. M. Damrauer, Scott M. Kumari, Meena Kivimaki, Mika van der Harst, Pim and Spector, Tim D. Loos, Ruth J. F. Province, Michael A. Psaty, Bruce M. Brandslund, Ivan Pramstaller, Peter P. Christensen, Kaare Ripatti, Samuli Widen, Elisabeth Hakonarson, Hakon and Grant, Struan F. A. Kiemeney, Lambertus A. L. M. de Graaf, Jacqueline Loeffler, Markus Kronenberg, Florian Gu, Dongfeng and Erdmann, Jeanette Schunkert, Heribert Franks, Paul W. and Linneberg, Allan Jukema, J. Wouter Khera, V, Amit Mannikko, Minna Jarvelin, Marjo-Riitta Kutalik, Zoltan Cucca, Francesco Mook-Kanamori, Dennis O. van Dijk, Ko Willems and Watkins, Hugh Strachan, David P. Grarup, Niels Sever, Peter and Poulter, Neil Rotter, I, Jerome Dantoft, Thomas M. and Karpe, Fredrik Neville, Matt J. Timpson, Nicholas J. Cheng, Ching-Yu Wong, Tien-Yin Khor, Chiea Chuen Sabanayagam, Charumathi Peters, Annette Gieger, Christian Hattersley, Andrew T. Pedersen, Nancy L. Magnusson, Patrik K. E. and Boomsma, I, Dorret de Geus, Eco J. C. Cupples, L. Adrienne and van Meurs, Joyce B. J. Ghanbari, Mohsen Rsen, Penny Gordon-La and Huang, Wei Kim, Young Jin Tabara, Yasuharu Wareham, Nicholas J. Langenberg, Claudia Zeggini, Eleftheria and Kuusisto, Johanna Laakso, Markku Ingelsson, Erik Abecasis, Goncalo Chambers, John C. Kooner, Jaspal S. de Vries, Paul S. Morrison, Alanna C. North, Kari E. Daviglus, Martha and Kraft, Peter Martin, Nicholas G. Whitfield, John B. Abbas, Shahid Saleheen, Danish Walters, Robin G. Holmes, V, Michael and Black, Corri Smith, Blair H. Justice, Anne E. Baras, Aris Buring, Julie E. Ridker, Paul M. Chasman, I, Daniel and Kooperberg, Charles Wei, Wei-Qi Jarvik, Gail P. Namjou, Bahram Hayes, M. Geoffrey Ritchie, Marylyn D. Jousilahti, Pekka Salomaa, Veikko Hveem, Kristian Asvold, Bjorn Olav and Kubo, Michiaki Kamatani, Yoichiro Okada, Yukinori Murakami, Yoshinori Thorsteinsdottir, Unnur Stefansson, Kari Ho, Yuk-Lam Lynch, Julie A. Rader, Daniel J. Tsao, Philip S. and Chang, Kyong-Mi Cho, Kelly O'Donnell, Christopher J. and Gaziano, John M. Wilson, Peter Rotimi, Charles N. and Hazelhurst, Scott Ramsay, Michele Trembath, Richard C. van Heel, David A. Tamiya, Gen Yamamoto, Masayuki Kim, Bong-Jo and Mohlke, Karen L. Frayling, Timothy M. Hirschhorn, Joel N. and Kathiresan, Sekar Boehnke, Michael Natarajan, Pradeep and Peloso, Gina M. Brown, Christopher D. Morris, Andrew P. and Assimes, Themistocles L. Deloukas, Panos Sun, V, Yan Willer, Cristen J.

Abstract

Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use(1). Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels(2), heart disease remains the leading cause of death worldwide(3). Genome-wideassociation studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS(4-23) have been conducted in European ancestry populations and may have missed genetic variants that contribute to lipid-level variation in other ancestry groups. These include differences in allele frequencies, effect sizes and linkage-disequilibrium patterns(24). Here we conduct a multi-ancestry, genome-wide genetic discovery meta-analysis of lipid levels in approximately 1.65 million individuals, including 350,000 of non-European ancestries. We quantify the gain in studying non-European ancestries and provide evidence to support the expansion of recruitment of additional ancestries, even with relatively small sample sizes. We find that increasing diversity rather than studying additional individuals of European ancestry results in substantial improvements in fine-mapping functional variants and portability of polygenic prediction (evaluated in approximately 295,000 individuals from 7 ancestry groupings). Modest gains in the number of discovered loci and ancestry-specific variants were also achieved. As GWAS expand emphasis beyond the identification of genes and fundamental biology towards the use of genetic variants for preventive and precision medicine(25), we anticipate that increased diversity of participants will lead to more accurate and equitable(26) application of polygenic scores in clinical practice.

Published
2021

247. Additional file 6 of Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark

Author

Nishal Kumar Pinna, Anjana, Ranjit Mohan, Saxena, Shruti, Anirban Dutta, Visvanathan Gnanaprakash, Gnanavadivel Rameshkumar, Sukumaran Aswath, Srividhya Raghavan, Coimbatore Subramanian Shanthi Rani, Venkatesan Radha, Muthuswamy Balasubramanyam, Pant, Archana, Nielsen, Trine, Jørgensen, Torben, Færch, Kristine, Alireza Kashani, Silva, Maria Camila Alvarez, Vestergaard, Henrik, Hansen, Tue Haldor, Hansen, Torben, Manimozhiyan Arumugam, Gopinath Balakrish Nair, Bhabatosh Das, Pedersen, Oluf, Viswanathan Mohan, and Mande, Sharmila Shekhar

Abstract

Additional file 6: Figures S1-S6. PDF file with all supplementary figures (Figures S1-S6) with corresponding figure legends.

Published
2021
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248. Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study (Diabetologia, (2020), 63, 4, (744-756), 10.1007/s00125-019-05083-6)

Author

Koivula, Robert W., Atabaki-Pasdar, Naeimeh, Giordano, Giuseppe N., White, Tom, Adamski, Jerzy, Bell, Jimmy D., Beulens, Joline, Brage, S. ren, Brunak, S. ren, de Masi, Federico, Dermitzakis, Emmanouil T., Forgie, Ian M., Frost, Gary, Hansen, Torben, Hansen, Tue H., Hattersley, Andrew, Kokkola, Tarja, Kurbasic, Azra, Laakso, Markku, Mari, Andrea, McDonald, Timothy J., Pedersen, Oluf, Rutters, Femke, Schwenk, Jochen M., Teare, Harriet J. A., Thomas, E. Louise, Vinuela, Ana, Mahajan, Anubha, McCarthy, Mark I., Ruetten, Hartmut, Walker, Mark, Pearson, Ewan, Pavo, Imre, Franks, Paul W., Epidemiology and Data Science, ACS - Diabetes & metabolism, APH - Health Behaviors & Chronic Diseases, APH - Aging & Later Life, and ACS - Heart failure & arrhythmias

Abstract

Unfortunately, ‘Present address’ was omitted from one of the addresses provided for Mark I. McCarthy (#26). The corrected address details are given on the following page.

Published
2021

249. Additional file 1 of Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India

Author

Alvarez-Silva, Camila, Alireza Kashani, Hansen, Tue Haldor, Nishal Kumar Pinna, Anjana, Ranjit Mohan, Anirban Dutta, Saxena, Shruti, Støy, Julie, Kampmann, Ulla, Nielsen, Trine, Jørgensen, Torben, Visvanathan Gnanaprakash, Rameshkumar Gnanavadivel, Aswath Sukumaran, Coimbatore Subramanian Shanthi Rani, Færch, Kristine, Venkatesan Radha, Muthuswamy Balasubramanyam, Gopinath Balakrish Nair, Bhabatosh Das, Vestergaard, Henrik, Hansen, Torben, Mande, Sharmila Shekhar, Viswanathan Mohan, Manimozhiyan Arumugam, and Pedersen, Oluf

Abstract

Additional file 1. Supplementary Material consisting two sections – Supplementary Methods and Supplementary Results (Format: PDF).

Published
2021
Full Text
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250. Additional file 1 of Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark

Author

Nishal Kumar Pinna, Anjana, Ranjit Mohan, Saxena, Shruti, Anirban Dutta, Visvanathan Gnanaprakash, Gnanavadivel Rameshkumar, Sukumaran Aswath, Srividhya Raghavan, Coimbatore Subramanian Shanthi Rani, Venkatesan Radha, Muthuswamy Balasubramanyam, Pant, Archana, Nielsen, Trine, Jørgensen, Torben, Færch, Kristine, Alireza Kashani, Silva, Maria Camila Alvarez, Vestergaard, Henrik, Hansen, Tue Haldor, Hansen, Torben, Manimozhiyan Arumugam, Gopinath Balakrish Nair, Bhabatosh Das, Pedersen, Oluf, Viswanathan Mohan, and Mande, Sharmila Shekhar

Subjects
InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, ComputingMilieux_COMPUTERSANDEDUCATION, Data_FILES, ComputerApplications_COMPUTERSINOTHERSYSTEMS
Abstract

Additional file 1: Supplementary methods. The file provides details of supplementary methods.

Published
2021
Full Text
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