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1,184,260 results on '"Paula, A."'

201. Higher Education Access for Undocumented Students in the United States: Mapping the Policy Terrain

Author

Katherine Cumings Mansfield and Paula Hernandez

Abstract

This article focuses on higher education access for undocumented immigrants in the United States. Since individual states develop and govern their own policies, the political landscape around college access is always in a state of flux. This is confusing to school counselors, families, and students. We use cartography to make sense of this increasingly complex policy terrain. In addition to displaying a state-by-state overview of access and funding options for undocumented students, we interrogate the (un)intended consequences of these policies and reveal "sites for change and activism" (Marx, 2023, p. 286).

Published
2024

202. Innovating Interdisciplinarity in Higher Education: Exploring the Impact of a Grassroots Community of Practice

Author

María Azucena Gutiérrez González, Caitlin Mandeville, Ferne Edwards, and Paula Rice

Abstract

Skills in interdisciplinary collaboration are required to address many complex problems facing society. As such, interdisciplinarity is a critical competency for students to develop. However, teachers' effectiveness in teaching interdisciplinarity is often hindered by silo structures within university faculties. To address this in the Experts in Teamwork (EiT) programme, a MSc in a Norwegian university that develops students' interdisciplinary teamwork skills through projects that address real-world challenges, a community of practice (CoP) evolved among teachers from different EiT classes. Over 20 months, CoP members participated in digital and in-person discussions, lecture exchanges, student and professional conferences, and coevaluation of student work, with an aim of better understanding interdisciplinarity and approaches for teaching it to students. The success of the CoP in achieving these aims was evaluated through a series of focus groups consisting of members of the CoP. The CoP achieved some success in fostering pedagogical conversations that were transformative for participants' understanding of interdisciplinarity in their practice. Participants reported that CoP participation influenced their interactions with students, ultimately helping students to develop a better understanding of interdisciplinarity. However, participants reported limitations in the CoP as a professional development resource, citing its newness and the required time commitment. Participants felt that these issues could be addressed via greater institutional support.

Published
2024

203. Colombian University Students' Experiences as Users of the English Language during International Mobility

Author

Paula Vanessa Bello and Melba Libia Cárdenas

Abstract

This exploratory case study analyzes Colombian university students' experiences as English users during international mobility. Data collected through surveys and interviews were examined based on content analysis and principles of grounded theory. The students' self-perceived English proficiency and communicative performance before and during international mobility were analyzed, while challenging areas were identified. The results evidence that mobility students have insufficient levels of English proficiency to engage in academic and social activities due to inadequate production skills and a lack of practice. The students also perceive university academic English opportunities for practice as basic, and they underutilize practice spaces. Nonetheless, they highlight that active engagement in autonomous language exposure and developed interpersonal skills positively impact their perception of language performance.

Published
2024

204. Reclaiming the Colombian English Language Teaching Field to Sow the Seeds of Change through Self-Study

Author

Paula Pérez-Rubiano, Anna Peñaloza-Rallón, Julieth López-Acevedo, and Sonia Camargo-Albarracín

Abstract

A growing interest in teacher identity and decision-making has emerged in language teaching; however, studies where English language teaching (ELT) educators reflect on their own practice are limited. We engaged in a self-study to understand how our experiences influenced our ELT educator identity at a public university in Colombia. A constructivist paradigm enabled us to focus on intra and interpersonal reflection as we created artifacts and met to discuss our teaching experiences. Using collaborative analysis, we developed our main themes represented by a red poppy. Based on the findings, our teaching identity is shaped by our families and teachers (roots), teaching misconceptions (leaves), new teaching experiences (new blossoms), other identities (petals), world views about education (cotton soul), and social justice agenda (seeds of change).

Published
2024

205. Factors Influencing Language Learning in Didactic Audiovisual Translation within the TRADILEX Project

Author

Paula Buil-Beltrán and María Bobadilla-Pérez

Abstract

This paper reports a mixed-method study on the factors shaping language learning through didactic audiovisual translation. The aim is to analyse the determinants influencing the effective implementation of an integrative project, revealing the strengths and weaknesses of the learning process. Data from 172 students were gathered through initial and final questionnaires, which offered insights into their perceptions of didactic audiovisual translation. The results demonstrate a noticeable shift in learners' attitudes towards audiovisual translation as a language learning tool during the tasks. This transformation led to the recognition of potential benefits, not only in conventional modes like subtitling and dubbing but also in less recognised modes such as audio-description and subtitling for the deaf and hard of hearing.

Published
2024

206. Service-Learning Methodology to Develop Bachelor's Thesis in Information and Computer Science Degrees

Author

Paula M. Castro, Óscar Fresnedo, Adriana Dapena, Javier Pereira, and Francisco J. Vázquez-Araujo

Abstract

Service-Learning (SL) is a powerful methodology to acquire competences and values in Higher Education. However, there is still no widespread use in Information and Computer Science (ICS) degrees where most of the subjects are focused on the development of theoretical and practical contents purely related to technical competences. In this paper, we show the structure of a SL methodology to develop Bachelor's Thesis: 1) definition of proposals considering all the competencies of the Bachelor's Thesis subject and the needs of entities; 2) development of applications using agile methodologies, and 3) assessment of the SL experience from students, entities and professors. We present an experience developed in the 2019/2020 academic year with two entities devoted to disfavoured people. The results show both the high technical and professional quality of the projects and the high satisfaction of entities and students. We hope that the development of applications with the collaboration of non-profit entities allows the acquisition of both specific and transversal competencies on ICS degrees at the same time enhancing the development of useful professional ones.

Published
2024

211. Cultural Agroecosystem Services Framework (Agro-CES): A Tool to Support Agricultural Sustainability Assessment

Author

Paula, Anabela, Roque, Natália, Martinho, Diogo, Frazão, Luciana, Fernandez, Paulo, Castro, Paula, Davim, J. Paulo, Series Editor, Brito, Paulo Sérgio, editor, da Costa Sanches Galvão, João Rafael, editor, Almeida, Henrique, editor, Rosa Ferreira, Liliana Catarina, editor, and Alves Flores de Oliveira Gala, Pedro Emanuel, editor

Published
2025
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212. 'Self' in Self-Study: Alongside Stories as Indigenously Understood Inquiry

Author

Cher Hill, Awneet Sivia, Vicki Kelly, Paula Rosehart, and Kau’i Keliipio

Abstract

As part of our ethical responsibilities as scholar-practitioners and community members living as uninvited guests on Indigenous territories, we engaged in a collaborative inquiry to explore ways in which Indigenous pedagogies and worldviews extend understandings of self within self-study research. Over several years, we engaged in reflective conversations about our respective tensions, challenges, and successes in the effort to decolonize and Indigenize our pedagogies and research. These conversations moved us over time to a particular orientation as we shared our life stories as educators and women. We began by documenting our experiences and reflections at each meeting and shared in meaning making how our orientations shifted to ways of being in relation. The emerging synergies of our relationality led us to name our experiences "alongside stories," in which we made meaning of the intersections and nuances between forms of self-study research and Indigenous Ways of Knowing. In sharing the alongside stories, we re-presented our collaborative understandings of inquiry as interweavings. These interweavings allowed us to explore how our knowledge and belief systems could be intertwined and disentwined to reveal resonances and particularities. Our exploration led us to reframe inquiry and self-study as Indigenously understood.

Published
2024
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213. How Free Tuition Became a Policy in Chile: The Importance of Policy Actors and Their Beliefs

Author

Paula Clasing-Manquian

Abstract

In recent decades, there has been a revival of free tuition policies around the world. Understanding the current revival of these policies is particularly important as it positions higher education as a social right or public good challenging the predominant discourse that situates higher education as a private good. Chile, a country often characterized as a neoliberal laboratory, implemented a free-tuition policy in 2016 and offers a case study to understand the policy formation and the political dynamics behind it. Based on the advocacy coalition framework and using discourse network analysis and in-depth interviews, this paper focuses on identifying the main actors involved in the policy discussion, their beliefs about free college in Chile, and how they interact during the policy development. Findings show that the Chilean free tuition policy was the result of the joint actions of actors who shared similar beliefs and formed coalitions to try to influence the policy design. Findings also highlight the formation of two opposite coalitions that were able to introduce their beliefs into the policy design at political and technical levels. Implications for policymakers and researchers are discussed.

Published
2024
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214. Mobilizing Strengths in the Development of French as a Second Language Teacher Identity

Author

Josée Le Bouthillier, Melissa Dockrill Garrett, and Paula Kristmanson

Abstract

Canada is facing a nationwide shortage of teachers of French as a second language. The profession is experiencing significant retention issues, with many teachers leaving the field within the first five years. One of the solutions proposed to address the challenges of teacher retention is for post-secondary institutions to integrate the concept and practice of professional identity development into teacher education programs (TEP). With a focus on their inherent strengths, students in a TEP were asked to keep a journal throughout their 10-month program identifying preconceived notions about teaching, critical incidents that arose, and how they endeavoured to confront or resolve them, as well as the knowledge of their character strengths that served to guide them in these efforts. This qualitative case study examines the process of one pre-service teacher in the initial development of their professional identity through the active use of self-reflective practice.

Published
2024
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215. Self-Perceived Bullying Victimization in Pre-Adolescents on the Autism Spectrum: EPINED Study

Author

Paula Morales-Hidalgo, Núria Voltas, and Josefa Canals

Abstract

Autistic individuals are at increased risk of experiencing various forms of victimization during their lifespan. This study analyses the self-reported prevalence of bullying victimization in autistic pre-adolescents and those with subthreshold autistic traits in comparison with peers without neurodevelopmental conditions. The sample was comprised of 323 participants (11 and 12 years old; 45 with autism or subthreshold autistic traits) from Spanish general education schools. The assessment protocol included psychopathological (autism characteristics and co-occurrent problems), cognitive and academic characteristics. Bullying victimization was self-reported by the pre-adolescents themselves using the Bullying and School Violence Questionnaire ("Acoso y violencia escolar"). Autistic participants (57.9%) and those with subthreshold autistic traits (26.9%) showed a higher rate of bullying victimization in comparison with their peers (18.3%). Bullying rates were more frequent and severe and were characterized by intimidation and social exclusion behaviours. These problems were associated with greater intensity of restrictive and repetitive behaviours and with more co-occurring behavioural and emotional problems. We did not find any association with other individual or family factors. Our data reveal the greater risk of bullying behaviours among autistic young people and those with subthreshold autistic traits, which implies the need for detection and establishment of protocols to prevent consequences for their mental health and quality of life.

Published
2024
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216. Calculating the Power of a Planned Individual Participant Data Meta-Analysis to Examine Prognostic Factor Effects for a Binary Outcome

Author

Rebecca Whittle, Joie Ensor, Miriam Hattle, Paula Dhiman, Gary S. Collins, and Richard D. Riley

Abstract

Collecting data for an individual participant data meta-analysis (IPDMA) project can be time consuming and resource intensive and could still have insufficient power to answer the question of interest. Therefore, researchers should consider the power of their planned IPDMA before collecting IPD. Here we propose a method to estimate the power of a planned IPDMA project aiming to synthesise multiple cohort studies to investigate the (unadjusted or adjusted) effects of potential prognostic factors for a binary outcome. We consider both binary and continuous factors and provide a three-step approach to estimating the power in advance of collecting IPD, under an assumption of the true prognostic effect of each factor of interest. The first step uses routinely available (published) aggregate data for each study to approximate Fisher's information matrix and thereby estimate the anticipated variance of the unadjusted prognostic factor effect in each study. These variances are then used in step 2 to estimate the anticipated variance of the summary prognostic effect from the IPDMA. Finally, step 3 uses this variance to estimate the corresponding IPDMA power, based on a two-sided Wald test and the assumed true effect. Extensions are provided to adjust the power calculation for the presence of additional covariates correlated with the prognostic factor of interest (by using a variance inflation factor) and to allow for between-study heterogeneity in prognostic effects. An example is provided for illustration, and Stata code is supplied to enable researchers to implement the method.

Published
2024
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217. Critical Thinking Evaluation Scale: Design and Validation in a Colombian Population

Author

María-Paula Rodríguez-Rojas, Ana-María Ramírez-Segura, Pedro Valenzuela-Mora, Julien Dampuré, and Fernando Riveros Munévar

Abstract

Critical thinking stands out as one of the most important cognitive abilities needed for effective adaptation to a knowledge-based society in the 21st century. Despite its significance, there remains a lack of consensus regarding the conceptual and methodological frameworks for measuring it. This study aimed to design and validate a comprehensive assessment scale for critical thinking. A specification table was constructed based on the critical thinking components agreed upon in the current literature, from which corresponding items were formulated and subsequently validated by expert judges. Following adjustments to the test, 258 Colombian participants completed it. Sample adequacy (KMO), Bartlett's sphericity, and collinearity were confirmed, and the results underwent exploratory factor analysis. Reliability analysis was conducted using McDonald's [omega], Cronbach's [alpha], Guttman's [lambda]6, and Greatest Lower Bound (GLB) statistics. The final test comprised 17 items organized into 2 constituent factors, demonstrating robust content and internal structure validity, as well as high levels of precision and internal consistency (overall GLB of 0.93). The Critical Thinking Evaluation Scale (CTES) exhibits validity and reliability for use within the Colombian population. Its adaptation for other contexts and countries, both Spanish and English-speaking, is recommended. The Spanish version, along with the validated English version for potential adaptations, and scoring norms are provided in the attached documents.

Published
2024
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218. Critical Antecedents of Mobile Learning Acceptance and Moderation Effects: A Meta-Analysis on Technology Acceptance Model

Author

Chenxi Liu, Yixi Wang, Marvin Evans, and Ana-Paula Correia

Abstract

Mobile learning has gained significant recognition for its beneficial effects on learning across various dimensions. Nonetheless, ensuring consistent learner acceptance of mobile learning remains a critical factor to address. This meta-analysis study is the first comprehensive examination of critical antecedents impacting learners' perceived usefulness and perceived ease of use of mobile learning within the Technology Acceptance Model. This study undertook a comprehensive analysis of prior research conducted in both English and Chinese languages during the last 22 years. The aim was to build the Integrated Mobile Learning Acceptance Model utilizing a one-stage meta-analysis structural equation model. Five major antecedents of perceived usefulness and perceived ease of use were identified, and the moderating effects of education level, region, and culture were revealed. The resulting model provides a cohesive framework for understanding the factors that influence learners' intention to use mobile learning across various contexts. At the same time, the results of the study contribute to the advancement of theory in mobile learning acceptance and have practical implications for the design and evaluation of mobile learning.

Published
2024
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219. Re-Imagining a Decolonised, Anti-Racist Curriculum within Initial Teacher Education in a Welsh University

Author

Susan Davis, Sharne Watkins, Chantelle Haughton, Eve Oliver, Josephine Farag, Paula Webber, and Samuel Goold

Abstract

Changes to the Welsh curriculum are becoming apparent. The Williams Report culminated in recommendations for schools and initial teacher education (ITE) on the inclusion and teaching of Black Asian and Minority Ethnic histories in Wales. The subsequent Welsh Government ITE action plan was designed to ensure the pro-active recruitment of trainee teachers from Black and racially minoritised backgrounds in Wales. As a result of this legislation, a team of ITE lecturers in a school of education in a Welsh university formed a research triad and larger research collective, the idea being that we needed to decolonise our own pedagogy and curriculum delivery and re-imagine ITE within an anti-racist paradigm. It was key to reflect on our ITE provision, ensuring that our curriculum delivery reflected the ambition of the new Curriculum for Wales, which encourages practitioners to think differently on what they teach, how they teach and what they want young people to learn. Using a patchwork methodology--which included 'deep thinking and deep listening'--we examined our current ITE delivery and work that has been done thus far and looked at the gains and areas for development. It became clear that staff within our 'ITE research collective' were becoming more knowledgeable and confident in working within a racial dynamic, and consequently felt more able to impart knowledge when engaging with other ITE colleagues and students. This paper charts our ongoing journey and makes recommendations gained from our experiences.

Published
2024
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220. Myths of Popular Psychology among University Students and Teachers: Does Training in Psychology Reduce Belief in Myths?

Author

Elena Varea, Ileana Enesco, Silvia Guerrero, and Paula Barrios

Abstract

Background: The study of myths in psychology has conceptual and educational relevance: How to adapt the teaching of psychology to confront myths with grounded knowledge? A first step is to know which myths prevail and its relation to training in psychology. Objective: To explore myth's prevalence among Spanish first-year university students of Social (SS) and Engineering Sciences (ES) (Study 1), and among different levels of expertise in psychology (Study 2). Method: Questionnaire including 21 myths. Study 1: 175 first-year SS and ES undergraduates. Study 2: 102 lay, semi-experts and experts in psychology. Results: Lower prevalence of myths among Spanish students than in other countries (approx. 37% vs. 60%), with SS students performing better than ES students. Experts performed significantly better (14% myths endorsed) than lay students (33%), but not than semi-experts (19%). Conclusions: The lower prevalence of myths compared to other countries may be due to methodological and sociocultural aspects. University training in psychology helps to better identify myths but does not eradicate them. Teaching Implications: Need to reflect on the little progress beyond a medium level of expertise. Teachers and students must identify their own myths and work on them in classroom, promoting critical thinking.

Published
2024
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221. Digital Teacher Training in the Portuguese National Plan for Digital Development at Schools: A Case Study

Author

Lénia Carvalhais and Paula Azevedo

Abstract

Schools have been responding to the ongoing digital transformation, which requires continuous self-reflection and decision-making skills from teachers in the inclusion of new digital technologies in the teaching and learning process. In the present study, descriptive measures were used to understand how 140 teachers, in a school group, perceived their digital competences through the Check-in Questionnaire (Study 1). A school group is a Portuguese organisational unit, constituted by different schools, catering to different age groups, managed by a single director. Study 2 addressed how this specific school group organised teacher training courses, considering the results of Check-in Questionnaire, and the scope of the National Digital Transition Plan. Interviews, in which data content analysis was applied, were undertaken with seven teacher instructors, selected to implement digital training. The results of Study 1 revealed that most teachers are positioned at level 2, an intermediate level, with no differences in age or years of service. In Study 2, instructors revealed that the proficiency level assigned in the Check-in Questionnaire did not always correspond to a teacher's real digital skills, identifying this as one of the obstacles to achieving the initial training aims. The goal of the training was for these professionals to feel committed to their educational context and understand what is intended in the inclusion of digital skills in the classroom. The relevance of this study relates to the current context, which places education and teachers at the centre of a digital agenda focused on the development of digital skills, thus generating new pedagogical practices, while accompanying the process from the initial assessment to the implementation of training in the National Digital Transition Plan.

Published
2024
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222. Item-Validity Analysis of the SED-S in a Multicentre Study of Adults with Intellectual Disabilities

Author

Hauke Hermann, Annemieke Witte, Gloria Kempelmann, Brian F. Barrett, Sandra Zaal, Jolanda Vonk, Filip Morisse, Anna Pöhlmann, Paula S. Sterkenburg, and Tanja Sappok

Abstract

Background: Valid and reliable instruments for measuring emotional development are critical for a proper diagnostic assignment in individuals with intellectual disabilities. This exploratory study examined the psychometric properties of the items on the Scale of Emotional Development--Short (SED-S). Method: The sample included 612 adults with intellectual disabilities (M[subscript age = 37.35, SD[subscript age] = 13.27; 59.8% males). Item validity analysis comprising sensitivity and specificity rates and discriminatory power were determined. Results: The relative mean frequency of 'yes' answers to all 200 items was 29.5%. The mean sensitivity rate was 67.5% and the mean specificity rate was 79.3%. Most items (85.0%) showed good discriminatory power with the adjacent stage(s), especially between SED-1, SED-2, SED-3 and SED-4. Particularly in SED-4 some items showed weaknesses in the differentiation between these stages. Discussion: This study adds to previous validation studies by showing that most SED-S items have psychometrically sound properties.

Published
2024
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223. The Concurrent Validity of the GORT-5 with the WJ-IV

Author

R. Lanai Jennings, Megan Midkiff, Emily Nestor McCauley, Jeremy Lopuch, Sandra Stroebel, Rachel James, Mary Toler, Rebecca Wendell, Paula King, and Mallory Frampton

Abstract

Reading comprehension is one of the most valuable academic skills taught in school. Selecting the appropriate assessment instrument to ensure early identification and intervention is important as there is an amalgam of cognitive abilities and academic skills involved in reading comprehension. The GORT-5 is the most recent edition of a test that measures reading rate, accuracy, fluency, and comprehension among school-age children and young adults. The current study evaluated the concurrent validity of the GORT-5 with the WJ-IV ACH for a group of referred students. Findings indicate that Pearson correlation coefficients for all GORT-5 and WJ-IV ACH score comparisons were very large (0.70-0.89). Generally, GORT-5 scores were 2-3 points higher than WJ-IV ACH cluster scores. The diagnostic accuracy of the GORT-5 is excellent, with very few students' scores yielding a false negative.

Published
2024
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224. The Role of Academic Performance, Prosocial Behaviour and Friendships on Adolescents' Preferred Studying Partners: A Longitudinal Social Network Analysis

Author

Diego Palacios, Christian Berger, Bernardette Paula Luengo Kanacri, Mark Huisman, and René Veenstra

Abstract

Background: Peers constitute an important developmental context for adolescent academic behaviour providing support and resources to either promote or discourage attitudes and behaviours that contribute to school success. When looking for academic help, students may prefer specific partners based on their social goals regarding academic performance. Aims: Based on the social goals for wanting to achieve academically (e.g., studying to be with friends, increasing/maintaining their own social status), we examine the extent to which adolescents' selection of preferred academic partners (with whom they would like to study) is driven by peers' academic performance, prosocial behaviour and friendships. Moreover, as high-achieving students play an important role in academic settings, whether they are more likely to prefer to study with similar high-achieving peers and friends was examined. Sample: A total of 537 seventh-grade students from 13 classes over three waves. Methods: Longitudinal social network analyses (RSiena). Results: Adolescents were more likely to select high achievers, friends and prosocial peers as preferred academic partners. Furthermore, high achievers were more likely to choose other high achievers and friends as preferred academic partners. Conclusions: Adolescents are likely to prefer as study partners someone they can learn from and who is more approachable, cooperative and friendly. Regarding high achievers, they would choose not only academic partners with similar academic interests and motivations to help them boost their academic achievement but also classmates with whom they like to spend time and share personal issues.

Published
2024
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225. Sociotechnical Imaginaries in Academic Medicine Strategic Planning: A Document Analysis

Author

Paula Rowland, Madison Brydges, and Kulamakan Kulasegaram

Abstract

Purpose: Along with other industries, healthcare is becoming increasingly digitized. Our study explores how the field of academic medicine is preparing for this digital future. Method: Active strategic plans available in English were collected from faculties of medicine in Canada (n = 14), departments in medical schools (n = 17), academic health science centres (n = 23) and associated research institutes (n = 5). In total, 59 strategic plans were subjected to a practice-oriented form of document analysis, informed by the concept of sociotechnical imaginaries. Results: On the one hand, digital health is discursively treated as a continuation of the academic medicine vision, with expansions of physician competencies and of research institutes contributions. These imaginaries do not necessarily disrupt the field of academic medicine as currently configured. On the other hand, there is a vision of digital health pursuing a robust sociotechnical future with transformative implications for how care is conducted, what forms of knowledge are prioritized, how patients and patienthood will be understood, and how data work will be distributed. This imaginary may destabilize existing distributions of knowledge and power. Conclusions: Looking through the lens of sociotechnical imaginaries, this study illuminates strategic plans as framing desirable futures, directing attention towards specific ways of understanding problems of healthcare, and mobilizing the resources to knit together social and technical systems in ways that bring these visions to fruition. There are bound to be tensions as these sociotechnical imaginaries are translated into material realities. Many of those tensions and their attempted resolutions will have direct implications for the expectations of health professional graduates, the nature of clinical learning environments, and future relationships with patients. Sociology of digital health and science and technology studies can provide useful insights to guide leaders in academic medicine shaping these digital futures.

Published
2024
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226. Student Life, Diverse Institutional Histories, and Archival Policy: Inclusion of Student Life Archival Material in University Archives' Collecting Statements

Author

Leanna M. Barcelona and Paula R. Dempsey

Abstract

Current literature outlines the importance of--and strategies for--collecting student life material in institutional archives but does not address the inclusion of this material within collecting statements. This study examines publicly available collecting statements from Association of Research Libraries (ARL) institutions' university archives, seeking mentions of student life archival material, diversity, and proactive approaches for collecting said material. Findings suggest that while many ARL institutions mention student life in these policies, most do not make the connection to how this material relates to diversity within the university archives, nor do they provide a proactive approach for collecting this material.

Published
2024
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227. How Do Authors Choose Keywords for Their Theses and Dissertations in Repositories of University Libraries? An Introspection-Based Enquiry

Author

Mariangela Spotti Lopes Fujita, Roberta Cristina Dal’Evedove Tartarotti, Paula Regina Dal´Evedove, and Maria Carolina Andrade e Cruz

Abstract

Considering the importance of subject retrieval for scientific visibility, and the need to guide authors in self-archiving their papers in institutional repositories of university libraries, this study observed the patterns and strategies used by authors while indexing for keyword assignment. The study examined four categories of analysis: criteria for keyword assignment; use of controlled vocabulary for keyword assignment; understanding of the importance of keywords; and ordering criteria and function of assigned keywords. The study found that, while assigning keywords, authors: consider fundamental concepts for representing significant content of the text; act as domain expert indexers; and are unaware that keyword assignment is an indexing process that requires controlled vocabularies. The research suggests that institutional repositories implement a hybrid information representation and retrieval system to allow for both the representation of more specific subjects of knowledge domains, as well as controlled vocabulary indexing terms.

Published
2024
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229. Amplitude analysis of the radiative decay $B^0_s\to K^+K^-\gamma$

Author

LHCb collaboration, Aaij, R., Abdelmotteleb, A. S. W., Beteta, C. Abellan, Abudinén, F., Ackernley, T., Adefisoye, A. A., Adeva, B., Adinolfi, M., Adlarson, P., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Aliouche, Z., Cartelle, P. Alvarez, Amalric, R., Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreianov, A., Andreola, P., Andreotti, M., Andreou, D., Anelli, A., Ao, D., Archilli, F., Argenton, M., Cuendis, S. Arguedas, Artamonov, A., Artuso, M., Aslanides, E., Atzeni, M., Audurier, B., Bacher, D., Perea, I. Bachiller, Bachmann, S., Bachmayer, M., Back, J. J., Rodriguez, P. Baladron, Balagura, V., Baldini, W., Bao, H., Leite, J. Baptista de Souza, Barbetti, M., Barbosa, I. R., Barlow, R. J., Barnyakov, M., Barsuk, S., Barter, W., Bartolini, M., Bartz, J., Baryshnikov, F., Basels, J. M., Bassi, G., Batsukh, B., Battig, A., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I. B., Belin, S., Bellee, V., Belous, K., Belov, I., Belyaev, I., Benane, G., Bencivenni, G., Ben-Haim, E., Berezhnoy, A., Bernet, R., Andres, S. Bernet, Bertolin, A., Betancourt, C., Betti, F., Bex, J., Bezshyiko, Ia., Bhom, J., Bieker, M. S., Biesuz, N. V., Billoir, P., Biolchini, A., Birch, M., Bishop, F. C. R., Bitadze, A., Bizzeti, A., Blake, T., Blanc, F., Blank, J. E., Blusk, S., Bocharnikov, V., Boelhauve, J. A., Garcia, O. Boente, Boettcher, T., Bohare, A., Boldyrev, A., Bolognani, C. S., Bolzonella, R., Bondar, N., Borgato, F., Borghi, S., Borsato, M., Borsuk, J. T., Bouchiba, S. A., Bowcock, T. J. V., Boyer, A., Bozzi, C., Bradley, M. J., Rodriguez, A. Brea, Breer, N., Brodzicka, J., Gonzalo, A. Brossa, Brown, J., Brundu, D., Buchanan, E., Buonaura, A., Buonincontri, L., Burke, A. T., Burr, C., Butkevich, A., Butter, J. S., Buytaert, J., Byczynski, W., Cadeddu, S., Cai, H., Calabrese, R., Ramirez, S. Calderon, Calefice, L., Cali, S., Calvi, M., Gomez, M. Calvo, Magalhaes, P. Camargo, Bouzas, J. I. Cambon, Campana, P., Perez, D. H. Campora, Quezada, A. F. Campoverde, Capelli, S., Capriotti, L., Caravaca-Mora, R., Carbone, A., Salgado, L. Carcedo, Cardinale, R., Cardini, A., Carniti, P., Carus, L., Vidal, A. Casais, Caspary, R., Casse, G., Godinez, J. Castro, Cattaneo, M., Cavallero, G., Cavallini, V., Celani, S., Cervenkov, D., Cesare, S., Chadwick, A. J., Chahrour, I., Charles, M., Charpentier, Ph., Barajas, C. A. Chavez, Chefdeville, M., Chen, C., Chen, S., Chen, Z., Chernov, A., Chernyshenko, S., Chobanova, V., Cholak, S., Chrzaszcz, M., Chubykin, A., Chulikov, V., Ciambrone, P., Vidal, X. Cid, Ciezarek, G., Cifra, P., Clarke, P. E. L., Clemencic, M., Cliff, H. V., Closier, J., Toapaxi, C. 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Subjects
High Energy Physics - Experiment
Abstract

A search for radiative decay of $B^0_s$ mesons to orbitally excited $K^+K^-$ states is performed using proton proton collisions recorded by the \mbox{LHCb}\xspace experiment, corresponding to an integrated luminosity of 9~fb$^{-1}$. The dikaon spectrum in the mass range $m_{KK}<2400$~{\ensuremath{\,\text{Me\kern -0.1em V\!/}c^2}\xspace} is dominated by the $\phi(1020)$ resonance that accounts for almost 70$\%$ of the decay rate. Considering the possible contributions of $f_2{(1270)}$, $f'_2{(1525)}$ and $f_2{(2010)}$ meson states, the overall tensor contribution to the amplitude is measured to be \begin{equation} {\cal F}_{\{f_2\}}=16.8\pm 0.5\mathrm{~(stat.)}\pm0.7\mathrm{~(syst.)}\%,\nonumber \end{equation} mostly dominated by the $f'_2(1525)$ state. Several statistically equivalent solutions are obtained for the detailed resonant structure depending on whether the smaller amplitudes interfere destructively or constructively with the dominant amplitude. The preferred solution that corresponds to the lowest values of the fit fractions along with constructive interference leads to the relative branching ratio measurement \begin{equation} \frac{{\cal B}(B^0_s\to f'_2\gamma)}{{\cal B}(B^0_s\to\phi\gamma)}= 19.4^{+0.9}_{-0.8}\mathrm{~(stat.)}{}^{+1.4}_{-0.5}\mathrm{~(syst.)}\pm0.5\mathrm{~(\cal{B})}\%\nonumber, \end{equation} where the last uncertainty is due to the ratio of measured branching fractions to the $K^+K^-$ final state. This result represents the first observation of the radiative $B^0_s\to f'_2(1525)\gamma$ decay, which is the second radiative transition observed in the $B^0_s$ sector., Comment: All figures and tables, along with any supplementary material and additional information, are available at https://lbfence.cern.ch/alcm/public/analysis/full-details/1791 (LHCb public pages)

Published
2024
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230. Comprehensive analysis of local and nonlocal amplitudes in the $B^0\rightarrow K^{*0}\mu^+\mu^-$ decay

Author

LHCb collaboration, Aaij, R., Abdelmotteleb, A. S. W., Beteta, C. Abellan, Abudinén, F., Ackernley, T., Adefisoye, A. A., Adeva, B., Adinolfi, M., Adlarson, P., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Aliouche, Z., Cartelle, P. Alvarez, Amalric, R., Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreianov, A., Andreola, P., Andreotti, M., Andreou, D., Anelli, A., Ao, D., Archilli, F., Argenton, M., Cuendis, S. Arguedas, Artamonov, A., Artuso, M., Aslanides, E., Da Silva, R. Ataide, Atzeni, M., Audurier, B., Bacher, D., Perea, I. Bachiller, Bachmann, S., Bachmayer, M., Back, J. J., Rodriguez, P. Baladron, Balagura, V., Baldini, W., Bao, H., Leite, J. Baptista de Souza, Barbetti, M., Barbosa, I. R., Barlow, R. J., Barnyakov, M., Barsuk, S., Barter, W., Bartolini, M., Bartz, J., Basels, J. M., Bassi, G., Batsukh, B., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I. B., Belin, S., Bellee, V., Belous, K., Belov, I., Belyaev, I., Benane, G., Bencivenni, G., Ben-Haim, E., Berezhnoy, A., Bernet, R., Andres, S. Bernet, Bertolin, A., Betancourt, C., Betti, F., Bex, J., Bezshyiko, Ia., Bhom, J., Bieker, M. S., Biesuz, N. V., Billoir, P., Biolchini, A., Birch, M., Bishop, F. C. R., Bitadze, A., Bizzeti, A., Blake, T., Blanc, F., Blank, J. E., Blusk, S., Bocharnikov, V., Boelhauve, J. A., Garcia, O. Boente, Boettcher, T., Bohare, A., Boldyrev, A., Bolognani, C. S., Bolzonella, R., Bondar, N., Borgato, F., Borghi, S., Borsato, M., Borsuk, J. T., Bouchiba, S. A., Bowcock, T. J. V., Boyer, A., Bozzi, C., Rodriguez, A. Brea, Breer, N., Brodzicka, J., Gonzalo, A. Brossa, Brown, J., Brundu, D., Buchanan, E., Buonaura, A., Buonincontri, L., Burke, A. T., Burr, C., Butkevich, A., Butter, J. S., Buytaert, J., Byczynski, W., Cadeddu, S., Cai, H., Calabrese, R., Ramirez, S. Calderon, Calefice, L., Cali, S., Calvi, M., Gomez, M. Calvo, Magalhaes, P. Camargo, Bouzas, J. I. Cambon, Campana, P., Perez, D. H. Campora, Quezada, A. F. Campoverde, Capelli, S., Capriotti, L., Caravaca-Mora, R., Carbone, A., Salgado, L. Carcedo, Cardinale, R., Cardini, A., Carniti, P., Carus, L., Vidal, A. Casais, Caspary, R., Casse, G., Godinez, J. Castro, Cattaneo, M., Cavallero, G., Cavallini, V., Celani, S., Cervenkov, D., Cesare, S., Chadwick, A. J., Chahrour, I., Charles, M., Charpentier, Ph., Chatzianagnostou, E., Barajas, C. A. Chavez, Chefdeville, M., Chen, C., Chen, S., Chen, Z., Chernov, A., Chernyshenko, S., Chobanova, V., Cholak, S., Chrzaszcz, M., Chubykin, A., Chulikov, V., Ciambrone, P., Vidal, X. Cid, Ciezarek, G., Cifra, P., Clarke, P. E. L., Clemencic, M., Cliff, H. V., Closier, J., Toapaxi, C. Cocha, Coco, V., Cogan, J., Cogneras, E., Cojocariu, L., Collins, P., Colombo, T., Comerma-Montells, A., Congedo, L., Contu, A., Cooke, N., Corredoira, I., Correia, A., Corti, G., Meldrum, J. J. Cottee, Couturier, B., Craik, D. C., Torres, M. 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Subjects
High Energy Physics - Experiment
Abstract

A comprehensive study of the local and nonlocal amplitudes contributing to the decay $B^0\rightarrow K^{*0}(\to K^+\pi^-) \mu^+\mu^-$ is performed by analysing the phase-space distribution of the decay products. The analysis is based on $pp$ collision data corresponding to an integrated luminosity of 8.4fb$^{-1}$ collected by the LHCb experiment. This measurement employs for the first time a model of both one-particle and two-particle nonlocal amplitudes, and utilises the complete dimuon mass spectrum without any veto regions around the narrow charmonium resonances. In this way it is possible to explicitly isolate the local and nonlocal contributions and capture the interference between them. The results show that interference with nonlocal contributions, although larger than predicted, only has a minor impact on the Wilson Coefficients determined from the fit to the data. For the local contributions, the Wilson Coefficient $C_9$, responsible for vector dimuon currents, exhibits a $2.1\sigma$ deviation from the Standard Model expectation. The Wilson Coefficients $C_{10}$, $C_{9}'$ and $C_{10}'$ are all in better agreement than $C_{9}$ with the Standard Model and the global significance is at the level of $1.5\sigma$. The model used also accounts for nonlocal contributions from $B^{0}\to K^{*0}\left[\tau^+\tau^-\to \mu^+\mu^-\right]$ rescattering, resulting in the first direct measurement of the $b s\tau\tau$ vector effective-coupling $C_{9\tau}$., Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2024-011.html (LHCb public pages)

Published
2024
Full Text
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231. Search for the lepton-flavor violating decay $B^0_s\to\phi\mu^\pm\tau^\mp$

Author

LHCb collaboration, Aaij, R., Abdelmotteleb, A. S. W., Beteta, C. Abellan, Abudinén, F., Ackernley, T., Adefisoye, A. A., Adeva, B., Adinolfi, M., Adlarson, P., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Aliouche, Z., Cartelle, P. Alvarez, Amalric, R., Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreianov, A., Andreola, P., Andreotti, M., Andreou, D., Anelli, A., Ao, D., Archilli, F., Argenton, M., Cuendis, S. Arguedas, Artamonov, A., Artuso, M., Aslanides, E., Atzeni, M., Audurier, B., Bacher, D., Perea, I. Bachiller, Bachmann, S., Bachmayer, M., Back, J. J., Rodriguez, P. Baladron, Balagura, V., Baldini, W., Bao, H., Leite, J. Baptista de Souza, Barbetti, M., Barbosa, I. R., Barlow, R. J., Barnyakov, M., Barsuk, S., Barter, W., Bartolini, M., Bartz, J., Baryshnikov, F., Basels, J. M., Bassi, G., Batsukh, B., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I. B., Belin, S., Bellee, V., Belous, K., Belov, I., Belyaev, I., Benane, G., Bencivenni, G., Ben-Haim, E., Berezhnoy, A., Bernet, R., Andres, S. Bernet, Bertolin, A., Betancourt, C., Betti, F., Bex, J., Bezshyiko, Ia., Bhom, J., Bieker, M. S., Biesuz, N. V., Billoir, P., Biolchini, A., Birch, M., Bishop, F. C. R., Bitadze, A., Bizzeti, A., Blake, T., Blanc, F., Blank, J. E., Blusk, S., Bocharnikov, V., Boelhauve, J. A., Garcia, O. Boente, Boettcher, T., Bohare, A., Boldyrev, A., Bolognani, C. S., Bolzonella, R., Bondar, N., Borgato, F., Borghi, S., Borsato, M., Borsuk, J. T., Bouchiba, S. A., Bowcock, T. J. V., Boyer, A., Bozzi, C., Bradley, M. J., Rodriguez, A. Brea, Breer, N., Brodzicka, J., Gonzalo, A. Brossa, Brown, J., Brundu, D., Buchanan, E., Buonaura, A., Buonincontri, L., Burke, A. T., Burr, C., Butkevich, A., Butter, J. S., Buytaert, J., Byczynski, W., Cadeddu, S., Cai, H., Calabrese, R., Ramirez, S. Calderon, Calefice, L., Cali, S., Calvi, M., Gomez, M. Calvo, Magalhaes, P. Camargo, Bouzas, J. I. Cambon, Campana, P., Perez, D. H. Campora, Quezada, A. F. Campoverde, Capelli, S., Capriotti, L., Caravaca-Mora, R., Carbone, A., Salgado, L. Carcedo, Cardinale, R., Cardini, A., Carniti, P., Carus, L., Vidal, A. Casais, Caspary, R., Casse, G., Godinez, J. Castro, Cattaneo, M., Cavallero, G., Cavallini, V., Celani, S., Cervenkov, D., Cesare, S., Chadwick, A. J., Chahrour, I., Charles, M., Charpentier, Ph., Barajas, C. A. Chavez, Chefdeville, M., Chen, C., Chen, S., Chen, Z., Chernov, A., Chernyshenko, S., Chobanova, V., Cholak, S., Chrzaszcz, M., Chubykin, A., Chulikov, V., Ciambrone, P., Vidal, X. Cid, Ciezarek, G., Cifra, P., Clarke, P. E. L., Clemencic, M., Cliff, H. V., Closier, J., Toapaxi, C. Cocha, Coco, V., Cogan, J., Cogneras, E., Cojocariu, L., Collins, P., Colombo, T., Comerma-Montells, A., Congedo, L., Contu, A., Cooke, N., Corredoira, I., Correia, A., Corti, G., Meldrum, J. J. Cottee, Couturier, B., Craik, D. C., Torres, M. Cruz, Rivera, E. 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Subjects
High Energy Physics - Experiment
Abstract

A search for the lepton-flavor violating decays $B^0_s\to\phi\mu^\pm\tau^\mp$ is presented, using a sample of proton-proton collisions at center-of-mass energies of 7, 8, and 13 TeV, collected with the LHCb detector and corresponding to a total integrated luminosity of $9\,\text{fb}^{-1}$. The $\tau$ leptons are selected using decays with three charged pions. No significant excess is observed, and an upper limit on the branching fraction is determined to be ${\cal B}( B^0_s\to\phi\mu^\pm\tau^\mp) < 1.0\times 10^{-5}$ at 90% confidence level., Comment: All figures and tables, along with any supplementary material and additional information, are available at https://lbfence.cern.ch/alcm/public/analysis/full-details/1788 (LHCb public pages)

Published
2024
Full Text
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232. Study of $b$-hadron decays to $\mathit{\Lambda}_{c}^+ h^- h^{\prime -}$ final states

Author

LHCb collaboration, Aaij, R., Abdelmotteleb, A. S. W., Beteta, C. Abellan, Abudinén, F., Ackernley, T., Adefisoye, A. A., Adeva, B., Adinolfi, M., Adlarson, P., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Aliouche, Z., Cartelle, P. Alvarez, Amalric, R., Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreianov, A., Andreola, P., Andreotti, M., Andreou, D., Anelli, A., Ao, D., Archilli, F., Argenton, M., Cuendis, S. Arguedas, Artamonov, A., Artuso, M., Aslanides, E., Da Silva, R. Ataide, Atzeni, M., Audurier, B., Bacher, D., Perea, I. Bachiller, Bachmann, S., Bachmayer, M., Back, J. J., Rodriguez, P. Baladron, Balagura, V., Baldini, W., Bao, H., Leite, J. Baptista de Souza, Barbetti, M., Barbosa, I. R., Barlow, R. J., Barnyakov, M., Barsuk, S., Barter, W., Bartolini, M., Bartz, J., Basels, J. M., Bassi, G., Batsukh, B., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I. B., Belin, S., Bellee, V., Belous, K., Belov, I., Belyaev, I., Benane, G., Bencivenni, G., Ben-Haim, E., Berezhnoy, A., Bernet, R., Andres, S. Bernet, Bertolin, A., Betancourt, C., Betti, F., Bex, J., Bezshyiko, Ia., Bhom, J., Bieker, M. S., Biesuz, N. V., Billoir, P., Biolchini, A., Birch, M., Bishop, F. C. R., Bitadze, A., Bizzeti, A., Blake, T., Blanc, F., Blank, J. E., Blusk, S., Bocharnikov, V., Boelhauve, J. A., Garcia, O. Boente, Boettcher, T., Bohare, A., Boldyrev, A., Bolognani, C. S., Bolzonella, R., Bondar, N., Borgato, F., Borghi, S., Borsato, M., Borsuk, J. T., Bouchiba, S. A., Bowcock, T. J. V., Boyer, A., Bozzi, C., Rodriguez, A. Brea, Breer, N., Brodzicka, J., Gonzalo, A. Brossa, Brown, J., Brundu, D., Buchanan, E., Buonaura, A., Buonincontri, L., Burke, A. T., Burr, C., Butkevich, A., Butter, J. S., Buytaert, J., Byczynski, W., Cadeddu, S., Cai, H., Calabrese, R., Ramirez, S. Calderon, Calefice, L., Cali, S., Calvi, M., Gomez, M. Calvo, Magalhaes, P. Camargo, Bouzas, J. I. Cambon, Campana, P., Perez, D. H. Campora, Quezada, A. F. Campoverde, Capelli, S., Capriotti, L., Caravaca-Mora, R., Carbone, A., Salgado, L. Carcedo, Cardinale, R., Cardini, A., Carniti, P., Carus, L., Vidal, A. Casais, Caspary, R., Casse, G., Godinez, J. Castro, Cattaneo, M., Cavallero, G., Cavallini, V., Celani, S., Cervenkov, D., Cesare, S., Chadwick, A. J., Chahrour, I., Charles, M., Charpentier, Ph., Chatzianagnostou, E., Barajas, C. A. Chavez, Chefdeville, M., Chen, C., Chen, S., Chen, Z., Chernov, A., Chernyshenko, S., Chobanova, V., Cholak, S., Chrzaszcz, M., Chubykin, A., Chulikov, V., Ciambrone, P., Vidal, X. Cid, Ciezarek, G., Cifra, P., Clarke, P. E. L., Clemencic, M., Cliff, H. V., Closier, J., Toapaxi, C. Cocha, Coco, V., Cogan, J., Cogneras, E., Cojocariu, L., Collins, P., Colombo, T., Comerma-Montells, A., Congedo, L., Contu, A., Cooke, N., Corredoira, I., Correia, A., Corti, G., Meldrum, J. J. Cottee, Couturier, B., Craik, D. C., Torres, M. Cruz, Rivera, E. Curras, Currie, R., Da Silva, C. L., Dadabaev, S., Dai, L., Dai, X., Dall'Occo, E., Dalseno, J., D'Ambrosio, C., Daniel, J., Danilina, A., d'Argent, P., Davidson, A., Davies, J. E., Davis, A., Francisco, O. De Aguiar, De Angelis, C., De Benedetti, F., de Boer, J., De Bruyn, K., De Capua, S., De Cian, M., Da Graca, U. De Freitas Carneiro, De Lucia, E., De Miranda, J. M., De Paula, L., De Serio, M., De Simone, P., De Vellis, F., de Vries, J. A., Debernardis, F., Decamp, D., Dedu, V., Del Buono, L., Delaney, B., Dembinski, H. -P., Deng, J., Denysenko, V., Deschamps, O., Dettori, F., Dey, B., Di Nezza, P., Diachkov, I., Didenko, S., Ding, S., Dittmann, L., Dobishuk, V., Docheva, A. D., Dong, C., Donohoe, A. M., Dordei, F., Reis, A. C. dos, Dowling, A. D., Duan, W., Duda, P., Dudek, M. W., Dufour, L., Duk, V., Durante, P., Duras, M. M., Durham, J. M., Durmus, O. 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Subjects
High Energy Physics - Experiment
Abstract

Decays of $\mathit{\Xi}_{b}^-$ and $\mathit{\Omega}_{b}^-$ baryons to $\mathit{\Lambda}_{c}^+ h^- h^{\prime -}$ final states, with $h^- h^{\prime -}$ being $\pi^-\pi^-$, $K^-\pi^-$ and $K^-K^-$ meson pairs, are searched for using data collected with the LHCb detector. The data sample studied corresponds to an integrated luminosity of $8.7\,\mathrm{fb}^{-1}$ of $pp$ collisions collected at centre-of-mass energies $\sqrt{s} = 7$, $8$ and $13\,\mathrm{Te\kern -0.1em V}$. The products of the relative branching fractions and fragmentation fractions for each signal mode, relative to the $B^- \to \mathit{\Lambda}_{c}^+ \overline{p} \pi^-$ mode, are measured, with $\mathit{\Xi}_{b}^- \to\mathit{\Lambda}_{c}^+ K^- \pi^-$, $\mathit{\Xi}_{b}^- \to\mathit{\Lambda}_{c}^+ K^- K^-$ and $\mathit{\Omega}_{b}^- \to\mathit{\Lambda}_{c}^+ K^- K^-$ decays being observed at over $5\,\sigma$ significance. The $\mathit{\Xi}_{b}^- \to\mathit{\Lambda}_{c}^+ K^- \pi^-$ mode is also used to measure the $\mathit{\Xi}_{b}^-$ production asymmetry, which is found to be consistent with zero. In addition, the $B^- \to \mathit{\Lambda}_{c}^+ \overline{p} K^-$ decay is observed for the first time, and its branching fraction is measured relative to that of the $B^- \to \mathit{\Lambda}_{c}^+ \overline{p} \pi^-$ mode., Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://lbfence.cern.ch/alcm/public/analysis/full-details/1789

Published
2024
Full Text
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233. Transverse polarization measurement of $\Lambda$ hyperons in $p$Ne collisions at $\sqrt{s_{NN}}$ = 68.4 GeV with the $\mbox{LHCb}$ detector

Author

LHCb collaboration, Aaij, R., Abdelmotteleb, A. S. W., Beteta, C. Abellan, Abudinén, F., Ackernley, T., Adefisoye, A. A., Adeva, B., Adinolfi, M., Adlarson, P., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Aliouche, Z., Cartelle, P. Alvarez, Amalric, R., Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreianov, A., Andreola, P., Andreotti, M., Andreou, D., Anelli, A., Ao, D., Archilli, F., Argenton, M., Cuendis, S. Arguedas, Artamonov, A., Artuso, M., Aslanides, E., Da Silva, R. Ataide, Atzeni, M., Audurier, B., Bacher, D., Perea, I. Bachiller, Bachmann, S., Bachmayer, M., Back, J. J., Rodriguez, P. Baladron, Balagura, V., Baldini, W., Bao, H., Leite, J. Baptista de Souza, Barbetti, M., Barbosa, I. R., Barlow, R. J., Barnyakov, M., Barsuk, S., Barter, W., Bartolini, M., Bartz, J., Basels, J. M., Bassi, G., Batsukh, B., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I. B., Belin, S., Bellee, V., Belous, K., Belov, I., Belyaev, I., Benane, G., Bencivenni, G., Ben-Haim, E., Berezhnoy, A., Bernet, R., Andres, S. Bernet, Bertolin, A., Betancourt, C., Betti, F., Bex, J., Bezshyiko, Ia., Bhom, J., Bieker, M. S., Biesuz, N. V., Billoir, P., Biolchini, A., Birch, M., Bishop, F. C. R., Bitadze, A., Bizzeti, A., Blake, T., Blanc, F., Blank, J. E., Blusk, S., Bocharnikov, V., Boelhauve, J. A., Garcia, O. Boente, Boettcher, T., Bohare, A., Boldyrev, A., Bolognani, C. S., Bolzonella, R., Bondar, N., Borgato, F., Borghi, S., Borsato, M., Borsuk, J. T., Bouchiba, S. A., Bowcock, T. J. V., Boyer, A., Bozzi, C., Rodriguez, A. Brea, Breer, N., Brodzicka, J., Gonzalo, A. Brossa, Brown, J., Brundu, D., Buchanan, E., Buonaura, A., Buonincontri, L., Burke, A. T., Burr, C., Butkevich, A., Butter, J. S., Buytaert, J., Byczynski, W., Cadeddu, S., Cai, H., Calabrese, R., Ramirez, S. Calderon, Calefice, L., Cali, S., Calvi, M., Gomez, M. Calvo, Magalhaes, P. Camargo, Bouzas, J. I. Cambon, Campana, P., Perez, D. H. Campora, Quezada, A. F. Campoverde, Capelli, S., Capriotti, L., Caravaca-Mora, R., Carbone, A., Salgado, L. Carcedo, Cardinale, R., Cardini, A., Carniti, P., Carus, L., Vidal, A. Casais, Caspary, R., Casse, G., Godinez, J. Castro, Cattaneo, M., Cavallero, G., Cavallini, V., Celani, S., Cervenkov, D., Cesare, S., Chadwick, A. J., Chahrour, I., Charles, M., Charpentier, Ph., Chatzianagnostou, E., Barajas, C. A. Chavez, Chefdeville, M., Chen, C., Chen, S., Chen, Z., Chernov, A., Chernyshenko, S., Chobanova, V., Cholak, S., Chrzaszcz, M., Chubykin, A., Chulikov, V., Ciambrone, P., Vidal, X. Cid, Ciezarek, G., Cifra, P., Clarke, P. E. L., Clemencic, M., Cliff, H. V., Closier, J., Toapaxi, C. Cocha, Coco, V., Cogan, J., Cogneras, E., Cojocariu, L., Collins, P., Colombo, T., Comerma-Montells, A., Congedo, L., Contu, A., Cooke, N., Corredoira, I., Correia, A., Corti, G., Meldrum, J. J. Cottee, Couturier, B., Craik, D. C., Torres, M. 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Subjects
High Energy Physics - Experiment
Abstract

A measurement of the transverse polarization of the $\Lambda$ and $\bar{\Lambda}$ hyperons in $p$Ne fixed-target collisions at $\sqrt{s_{NN}}$ = 68.4 GeV is presented using data collected by the LHCb detector. The polarization is studied using the decay $\Lambda \rightarrow p \pi^-$ together with its charge conjugated process, the integrated values measured are $$ P_{\Lambda} = 0.029 \pm 0.019 \, (\rm{stat}) \pm 0.012 \, (\rm{syst}) \, , $$ $$ P_{\bar{\Lambda}} = 0.003 \pm 0.023 \, (\rm{stat}) \pm 0.014 \,(\rm{syst}) \,. $$ Furthermore, the results are shown as a function of the Feynman~$x$~variable, transverse momentum, pseudorapidity and rapidity of the hyperons, and are compared with previous measurements., Comment: All figures and tables, along with any supplementary material and additional information, are available at https://lbfence.cern.ch/alcm/public/analysis/full-details/3120 (LHCb public pages)

Published
2024
Full Text
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234. Search for time-dependent $CP$ violation in $D^0 \rightarrow \pi^+ \pi^- \pi^0$ decays

Author

LHCb collaboration, Aaij, R., Abdelmotteleb, A. S. W., Beteta, C. Abellan, Abudinén, F., Ackernley, T., Adefisoye, A. A., Adeva, B., Adinolfi, M., Adlarson, P., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Aliouche, Z., Cartelle, P. Alvarez, Amalric, R., Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreianov, A., Andreola, P., Andreotti, M., Andreou, D., Anelli, A., Ao, D., Archilli, F., Argenton, M., Cuendis, S. Arguedas, Artamonov, A., Artuso, M., Aslanides, E., Atzeni, M., Audurier, B., Bacher, D., Perea, I. Bachiller, Bachmann, S., Bachmayer, M., Back, J. J., Rodriguez, P. Baladron, Balagura, V., Baldini, W., Bao, H., Leite, J. Baptista de Souza, Barbetti, M., Barbosa, I. R., Barlow, R. J., Barnyakov, M., Barsuk, S., Barter, W., Bartolini, M., Bartz, J., Baryshnikov, F., Basels, J. M., Bassi, G., Batsukh, B., Battig, A., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I. B., Belin, S., Bellee, V., Belous, K., Belov, I., Belyaev, I., Benane, G., Bencivenni, G., Ben-Haim, E., Berezhnoy, A., Bernet, R., Andres, S. Bernet, Bertolin, A., Betancourt, C., Betti, F., Bex, J., Bezshyiko, Ia., Bhom, J., Bieker, M. S., Biesuz, N. V., Billoir, P., Biolchini, A., Birch, M., Bishop, F. C. R., Bitadze, A., Bizzeti, A., Blake, T., Blanc, F., Blank, J. E., Blusk, S., Bocharnikov, V., Boelhauve, J. A., Garcia, O. Boente, Boettcher, T., Bohare, A., Boldyrev, A., Bolognani, C. S., Bolzonella, R., Bondar, N., Borgato, F., Borghi, S., Borsato, M., Borsuk, J. T., Bouchiba, S. A., Bowcock, T. J. V., Boyer, A., Bozzi, C., Bradley, M. J., Rodriguez, A. Brea, Breer, N., Brodzicka, J., Gonzalo, A. Brossa, Brown, J., Brundu, D., Buchanan, E., Buonaura, A., Buonincontri, L., Burke, A. T., Burr, C., Butkevich, A., Butter, J. 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Subjects
High Energy Physics - Experiment
Abstract

A measurement of time-dependent $CP$ violation in $D^0 \rightarrow \pi^+ \pi^- \pi^0$ decays using a $pp$ collision data sample collected by the LHCb experiment in 2012 and from 2015 to 2018, corresponding to an integrated luminosity of 7.7$\,\mathrm{fb}^{-1}$, is presented. The initial flavour of each $D^0$ candidate is determined from the charge of the pion produced in the $D^*(2010)^+ \rightarrow D^0 \pi^+$ decay. The decay $D^0 \rightarrow K^- \pi^+ \pi^0$ is used as a control channel to validate the measurement procedure. The gradient of the time-dependent $CP$ asymmetry, $\Delta Y$, in $D^0 \rightarrow \pi^+ \pi^- \pi^0$ decays is measured to be \begin{equation*} \Delta Y = (-1.3 \pm 6.3 \pm 2.4) \times 10^{-4}, \end{equation*} where the first uncertainty is statistical and the second is systematic, which is compatible with $CP$ conservation., Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://lbfence.cern.ch/alcm/public/analysis/full-details/1787

Published
2024
Full Text
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235. Amplitude analysis and branching fraction measurement of $B^{+}\to D^{*-}D^{+}_{s}\pi^{+}$ decays

Author

LHCb collaboration, Aaij, R., Abdelmotteleb, A. S. W., Beteta, C. Abellan, Abudinén, F., Ackernley, T., Adefisoye, A. A., Adeva, B., Adinolfi, M., Adlarson, P., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Aliouche, Z., Cartelle, P. Alvarez, Amalric, R., Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreianov, A., Andreola, P., Andreotti, M., Andreou, D., Anelli, A., Ao, D., Archilli, F., Argenton, M., Cuendis, S. Arguedas, Artamonov, A., Artuso, M., Aslanides, E., Atzeni, M., Audurier, B., Bacher, D., Perea, I. Bachiller, Bachmann, S., Bachmayer, M., Back, J. J., Rodriguez, P. Baladron, Balagura, V., Baldini, W., Bao, H., Leite, J. Baptista de Souza, Barbetti, M., Barbosa, I. R., Barlow, R. J., Barnyakov, M., Barsuk, S., Barter, W., Bartolini, M., Bartz, J., Baryshnikov, F., Basels, J. M., Bassi, G., Batsukh, B., Battig, A., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I. B., Belin, S., Bellee, V., Belous, K., Belov, I., Belyaev, I., Benane, G., Bencivenni, G., Ben-Haim, E., Berezhnoy, A., Bernet, R., Andres, S. Bernet, Bertolin, A., Betancourt, C., Betti, F., Bex, J., Bezshyiko, Ia., Bhom, J., Bieker, M. S., Biesuz, N. V., Billoir, P., Biolchini, A., Birch, M., Bishop, F. C. R., Bitadze, A., Bizzeti, A., Blake, T., Blanc, F., Blank, J. E., Blusk, S., Bocharnikov, V., Boelhauve, J. A., Garcia, O. Boente, Boettcher, T., Bohare, A., Boldyrev, A., Bolognani, C. S., Bolzonella, R., Bondar, N., Borgato, F., Borghi, S., Borsato, M., Borsuk, J. T., Bouchiba, S. A., Bowcock, T. J. V., Boyer, A., Bozzi, C., Bradley, M. J., Rodriguez, A. Brea, Breer, N., Brodzicka, J., Gonzalo, A. Brossa, Brown, J., Brundu, D., Buchanan, E., Buonaura, A., Buonincontri, L., Burke, A. T., Burr, C., Butkevich, A., Butter, J. S., Buytaert, J., Byczynski, W., Cadeddu, S., Cai, H., Calabrese, R., Ramirez, S. Calderon, Calefice, L., Cali, S., Calvi, M., Gomez, M. Calvo, Bouzas, J. I. Cambon, Campana, P., Perez, D. H. Campora, Quezada, A. F. Campoverde, Capelli, S., Capriotti, L., Caravaca-Mora, R., Carbone, A., Salgado, L. Carcedo, Cardinale, R., Cardini, A., Carniti, P., Carus, L., Vidal, A. Casais, Caspary, R., Casse, G., Godinez, J. Castro, Cattaneo, M., Cavallero, G., Cavallini, V., Celani, S., Cervenkov, D., Cesare, S., Chadwick, A. J., Chahrour, I., Charles, M., Charpentier, Ph., Barajas, C. A. Chavez, Chefdeville, M., Chen, C., Chen, S., Chen, Z., Chernov, A., Chernyshenko, S., Chobanova, V., Cholak, S., Chrzaszcz, M., Chubykin, A., Chulikov, V., Ciambrone, P., Vidal, X. Cid, Ciezarek, G., Cifra, P., Clarke, P. E. L., Clemencic, M., Cliff, H. V., Closier, J., Toapaxi, C. 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Subjects
High Energy Physics - Experiment
Abstract

The decays of the $B^{+}$ meson to the final state $D^{*-}D^{+}_{s}\pi^{+}$ are studied in proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7, 8, and 13 TeV, corresponding to a total integrated luminosity of 9 fb$^{-1}$. The ratio of branching fractions of the $B^{+}\to D^{*-}D^{+}_{s}\pi^{+}$ and $B^{0}\to D^{*-}D^{+}_{s}$ decays is measured to be $0.173\pm 0.006\pm 0.010$, where the first uncertainty is statistical and the second is systematic. Using partially reconstructed $D^{*+}_{s}\to D^{+}_{s}\gamma$ and $D^{+}_{s}\pi^{0}$ decays, the ratio of branching fractions between the $B^{+}\to D^{*-}D^{*+}_{s}\pi^{+}$ and $B^{+}\to D^{*-}D^{+}_{s}\pi^{+}$ decays is determined as $1.31\pm 0.07\pm 0.14$. An amplitude analysis of the $B^{+}\to D^{*-}D^{+}_{s}\pi^{+}$ decay is performed for the first time, revealing dominant contributions from known excited charm resonances decaying to the $D^{*-}\pi^{+}$ final state. No significant evidence of exotic contributions in the $D^{+}_{s}\pi^{+}$ or $D^{*-}D^{+}_{s}$ channels is found. The fit fraction of the scalar state $T_{c\bar{s} 0}^{\ast}(2900)^{++}$ observed in the $B^{+}\to D^{-}D^{+}_{s}\pi^{+}$ decay is determined to be less than 2.3% at a 90% confidence level., Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2024-001.html (LHCb public pages)

Published
2024
Full Text
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236. First observation of $\Lambda_{b}^{0} \rightarrow \Sigma_c^{(*)++} D^{(*)-} K^{-}$ decays

Author

LHCb collaboration, Aaij, R., Abdelmotteleb, A. S. W., Beteta, C. Abellan, Abudinén, F., Ackernley, T., Adefisoye, A. A., Adeva, B., Adinolfi, M., Adlarson, P., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Aliouche, Z., Cartelle, P. Alvarez, Amalric, R., Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreianov, A., Andreola, P., Andreotti, M., Andreou, D., Anelli, A., Ao, D., Archilli, F., Argenton, M., Cuendis, S. Arguedas, Artamonov, A., Artuso, M., Aslanides, E., Atzeni, M., Audurier, B., Bacher, D., Perea, I. Bachiller, Bachmann, S., Bachmayer, M., Back, J. J., Rodriguez, P. Baladron, Balagura, V., Baldini, W., Leite, J. Baptista de Souza, Barbetti, M., Barbosa, I. R., Barlow, R. J., Barsuk, S., Barter, W., Bartolini, M., Bartz, J., Baryshnikov, F., Basels, J. M., Bassi, G., Batsukh, B., Battig, A., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I. B., Beiter, A., Belin, S., Bellee, V., Belous, K., Belov, I., Belyaev, I., Benane, G., Bencivenni, G., Ben-Haim, E., Berezhnoy, A., Bernet, R., Andres, S. Bernet, Bertella, C., Bertolin, A., Betancourt, C., Betti, F., Bex, J., Bezshyiko, Ia., Bhom, J., Bieker, M. S., Biesuz, N. V., Billoir, P., Biolchini, A., Birch, M., Bishop, F. C. R., Bitadze, A., Bizzeti, A., Blake, T., Blanc, F., Blank, J. E., Blusk, S., Bocharnikov, V., Boelhauve, J. A., Garcia, O. Boente, Boettcher, T., Bohare, A., Boldyrev, A., Bolognani, C. S., Bolzonella, R., Bondar, N., Borgato, F., Borghi, S., Borsato, M., Borsuk, J. T., Bouchiba, S. A., Bowcock, T. J. V., Boyer, A., Bozzi, C., Bradley, M. J., Rodriguez, A. Brea, Breer, N., Brodzicka, J., Gonzalo, A. Brossa, Brown, J., Brundu, D., Buchanan, E., Buonaura, A., Buonincontri, L., Burke, A. T., Burr, C., Bursche, A., Butkevich, A., Butter, J. S., Buytaert, J., Byczynski, W., Cadeddu, S., Cai, H., Calabrese, R., Calefice, L., Cali, S., Calvi, M., Gomez, M. 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Subjects
High Energy Physics - Experiment
Abstract

The four decays, $\Lambda_{b}^{0} \rightarrow \Sigma_c^{(*)++} D^{(*)-} K^{-}$, are observed for the first time using proton-proton collision data collected with the LHCb detector at a centre-of-mass energy of $13\,\rm{TeV}$, corresponding to an integrated luminosity of $6\,\rm{fb}^{-1}$. By considering the $\Lambda_b^0 \rightarrow \Lambda_c^{+} \overline{D}^0 K^{-}$ decay as reference channel, the following branching fraction ratios are measured to be $$\frac{\cal{B} (\Lambda_{b}^{0} \rightarrow \Sigma_{c}^{++} \rm{D}^{-} {K}^{-})}{\cal{B}(\Lambda_{b}^{0} \rightarrow \Lambda_c^{+} \rm \overline{D}^0 {K}^{-})} = {0.282}\pm{0.016}\pm{0.016}\pm{0.005}, \frac{\cal{B}(\Lambda_{b}^{0} \rightarrow \Sigma_{c}^{*++} \rm {D}^{-} {K}^{-})}{\cal{B}(\Lambda_{b}^{0} \rightarrow \Sigma_c^{++} \rm {D}^{-} {K}^{-})} = {0.460}\pm{0.052}\pm{0.028}, \frac{\cal{B}(\Lambda_{b}^{0} \rightarrow \Sigma_{c}^{++} \rm {D}^{*-} {K}^{-})}{\cal{B}(\Lambda_{b}^{0} \rightarrow \Sigma_c^{++} \rm {D}^{-} {K}^{-})} = {2.261}\pm{0.202}\pm{0.129}\pm{0.046}, \frac{\cal{B}(\Lambda_{b}^{0} \rightarrow \Sigma_{c}^{*++} \rm D^{*-} K^{-})}{\cal{B}(\Lambda_{b}^{0} \rightarrow \Sigma_c^{++} \rm D^{-} K^{-})} = {0.896}\pm{0.137}\pm{0.066}\pm{0.018},$$ where the first uncertainties are statistical, the second are systematic, and the third are due to uncertainties in the branching fractions of intermediate particle decays. These initial observations mark the beginning of pentaquark searches in these modes, with more data set to become available following the LHCb upgrade., Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-044.html (LHCb public pages)

Published
2024
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237. Search for prompt production of pentaquarks in charm hadron final states

Author

LHCb collaboration, Aaij, R., Abdelmotteleb, A. S. W., Beteta, C. Abellan, Abudinén, F., Ackernley, T., Adeva, B., Adinolfi, M., Adlarson, P., Afsharnia, H., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Albero, A. Alfonso, Aliouche, Z., Cartelle, P. Alvarez, Amalric, R., Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreianov, A., Andreola, P., Andreotti, M., Andreou, D., Ao, D., Archilli, F., Cuendis, S. Arguedas, Artamonov, A., Artuso, M., Aslanides, E., Atzeni, M., Audurier, B., Bacher, D., Perea, I. Bachiller, Bachmann, S., Bachmayer, M., Back, J. J., Bailly-reyre, A., Rodriguez, P. Baladron, Balagura, V., Baldini, W., Leite, J. Baptista de Souza, Barbetti, M., Barbosa, I. R., Barlow, R. J., Barsuk, S., Barter, W., Bartolini, M., Baryshnikov, F., Basels, J. M., Bassi, G., Batsukh, B., Battig, A., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I. 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Subjects
High Energy Physics - Experiment
Abstract

A search for hidden-charm pentaquark states decaying to a range of $\Sigma_{c}\bar{D}$ and $\Lambda_{c}\bar{D}$ final states, as well as doubly-charmed pentaquark states to $\Sigma_{c}D$ and $\Lambda_{c}^{+}D$, is made using samples of proton-proton collision data corresponding to an integrated luminosity of $5.7fb^{-1}$ recorded by the LHCb detector at $\sqrt{s} = 13Te\kern -0.1em V$. Since no significant signals are found, upper limits are set on the pentaquark yields relative to that of the $\Lambda_{c}^{+}$ baryon in the $\Lambda_{c}^{+}\to pK^{-}\pi^{+}$ decay mode. The known pentaquark states are also investigated, and their signal yields are found to be consistent with zero in all cases., Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-018.html (LHCb public pages)

Published
2024
Full Text
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238. Search for the $B_s^0 \rightarrow \mu^+\mu^-\gamma$ decay

Author

LHCb collaboration, Aaij, R., Abdelmotteleb, A. S. W., Beteta, C. Abellan, Abudinén, F., Ackernley, T., Adefisoye, A. A., Adeva, B., Adinolfi, M., Adlarson, P., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Aliouche, Z., Cartelle, P. Alvarez, Amalric, R., Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreianov, A., Andreola, P., Andreotti, M., Andreou, D., Anelli, A., Ao, D., Archilli, F., Argenton, M., Cuendis, S. Arguedas, Artamonov, A., Artuso, M., Aslanides, E., Atzeni, M., Audurier, B., Bacher, D., Perea, I. Bachiller, Bachmann, S., Bachmayer, M., Back, J. J., Rodriguez, P. Baladron, Balagura, V., Baldini, W., Leite, J. Baptista de Souza, Barbetti, M., Barbosa, I. R., Barlow, R. J., Barsuk, S., Barter, W., Bartolini, M., Bartz, J., Baryshnikov, F., Basels, J. M., Bassi, G., Batsukh, B., Battig, A., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I. B., Beiter, A., Belin, S., Bellee, V., Belous, K., Belov, I., Belyaev, I., Benane, G., Bencivenni, G., Ben-Haim, E., Berezhnoy, A., Bernet, R., Andres, S. Bernet, Bertella, C., Bertolin, A., Betancourt, C., Betti, F., Bex, J., Bezshyiko, Ia., Bhom, J., Bieker, M. S., Biesuz, N. V., Billoir, P., Biolchini, A., Birch, M., Bishop, F. C. R., Bitadze, A., Bizzeti, A., Blake, T., Blanc, F., Blank, J. E., Blusk, S., Bocharnikov, V., Boelhauve, J. A., Garcia, O. Boente, Boettcher, T., Bohare, A., Boldyrev, A., Bolognani, C. S., Bolzonella, R., Bondar, N., Borgato, F., Borghi, S., Borsato, M., Borsuk, J. T., Bouchiba, S. A., Bowcock, T. J. V., Boyer, A., Bozzi, C., Bradley, M. J., Rodriguez, A. Brea, Breer, N., Brodzicka, J., Gonzalo, A. Brossa, Brown, J., Brundu, D., Buchanan, E., Buonaura, A., Buonincontri, L., Burke, A. T., Burr, C., Bursche, A., Butkevich, A., Butter, J. S., Buytaert, J., Byczynski, W., Cadeddu, S., Cai, H., Calabrese, R., Calefice, L., Cali, S., Calvi, M., Gomez, M. 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Subjects
High Energy Physics - Experiment
Abstract

A search for the fully reconstructed $B_s^0 \rightarrow \mu^+\mu^-\gamma$ decay is performed at the LHCb experiment using proton-proton collisions at $\sqrt{s}=13$\,TeV corresponding to an integrated luminosity of $5.4\,\mathrm{fb^{-1}}$. No significant signal is found and upper limits on the branching fraction in intervals of the dimuon mass are set \begin{align} {\cal B}(B_s^0 \rightarrow \mu^+\mu^-\gamma) < 4.2\times10^{-8},~&m(\mu\mu)\in[2m_\mu,~1.70]\,\mathrm{GeV/c^2} ,\nonumber {\cal B}(B_s^0 \rightarrow \mu^+\mu^-\gamma) < 7.7\times10^{-8},~&m(\mu\mu)\in[1.70,~2.88]\,\mathrm{GeV/c^2},\nonumber {\cal B}(B_s^0 \rightarrow \mu^+\mu^-\gamma) < 4.2\times10^{-8},~&m(\mu\mu)\in[3.92 ,~m_{B_s^0}]\,\mathrm{GeV/c^2},\nonumber \end{align} at 95\% confidence level. Additionally, upper limits are set on the branching fraction in the $[2m_\mu,~1.70]\,\mathrm{GeV/c^2}$ dimuon mass region excluding the contribution from the intermediate $\phi(1020)$ meson, and in the region combining all dimuon-mass intervals., Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-045.html

Published
2024
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239. Tracking of charged particles with nanosecond lifetimes at LHCb

Author

LHCb collaboration, Aaij, R., Abdelmotteleb, A. S. W., Beteta, C. Abellan, Abudinén, F., Ackernley, T., Adams, J. A., Adefisoye, A. A., Adeva, B., Adinolfi, M., Adlarson, P., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Aliouche, Z., Cartelle, P. Alvarez, Amalric, R., Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreianov, A., Andreola, P., Andreotti, M., Andreou, D., Anelli, A., Ao, D., Archilli, F., Argenton, M., Cuendis, S. Arguedas, Artamonov, A., Artuso, M., Aslanides, E., Atzeni, M., Audurier, B., Bacher, D., Perea, I. Bachiller, Bachmann, S., Bachmayer, M., Back, J. J., Rodriguez, P. Baladron, Balagura, V., Baldini, W., Bao, H., Leite, J. Baptista de Souza, Barbetti, M., Barbosa, I. R., Barlow, R. J., Barnyakov, M., Barsuk, S., Barter, W., Bartolini, M., Bartz, J., Baryshnikov, F., Basels, J. 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Subjects
High Energy Physics - Experiment
Abstract

A method is presented to reconstruct charged particles with lifetimes between 10 ps and 10 ns, which considers a combination of their decay products and the partial tracks created by the initial charged particle. Using the $\Xi^-$ baryon as a benchmark, the method is demonstrated with simulated events and proton-proton collision data at $\sqrt{s}=13$ TeV, corresponding to an integrated luminosity of 2.0 fb${}^{-1}$ collected with the LHCb detector in 2018. Significant improvements in the angular resolution and the signal purity are obtained. The method is implemented as part of the LHCb Run 3 event trigger in a set of requirements to select detached hyperons. This is the first demonstration of the applicability of this approach at the LHC, and the first to show its scaling with instantaneous luminosity., Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-DP-2023-004.html (LHCb public pages)

Published
2024
Full Text
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240. Amplitude analysis of the $\Lambda_b^0\to pK^-\gamma$ decay

Author

LHCb collaboration, Aaij, R., Abdelmotteleb, A. S. W., Beteta, C. Abellan, Abudinén, F., Ackernley, T., Adeva, B., Adinolfi, M., Adlarson, P., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Albero, A. Alfonso, Aliouche, Z., Cartelle, P. Alvarez, Amalric, R., Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreianov, A., Andreola, P., Andreotti, M., Andreou, D., Anelli, A., Ao, D., Archilli, F., Argenton, M., Cuendis, S. Arguedas, Artamonov, A., Artuso, M., Aslanides, E., Atzeni, M., Audurier, B., Bacher, D., Perea, I. Bachiller, Bachmann, S., Bachmayer, M., Back, J. J., Rodriguez, P. Baladron, Balagura, V., Baldini, W., Leite, J. Baptista de Souza, Barbetti, M., Barbosa, I. R., Barlow, R. J., Barsuk, S., Barter, W., Bartolini, M., Bartz, J., Baryshnikov, F., Basels, J. M., Bassi, G., Batsukh, B., Battig, A., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I. B., Beiter, A., Belin, S., Bellee, V., Belous, K., Belov, I., Belyaev, I., Benane, G., Bencivenni, G., Ben-Haim, E., Berezhnoy, A., Bernet, R., Andres, S. Bernet, Bernstein, H. C., Bertella, C., Bertolin, A., Betancourt, C., Betti, F., Bex, J., Bezshyiko, Ia., Bhom, J., Bieker, M. S., Biesuz, N. V., Billoir, P., Biolchini, A., Birch, M., Bishop, F. C. R., Bitadze, A., Bizzeti, A., Blago, M. P., Blake, T., Blanc, F., Blank, J. E., Blusk, S., Bobulska, D., Bocharnikov, V., Boelhauve, J. A., Garcia, O. Boente, Boettcher, T., Bohare, A., Boldyrev, A., Bolognani, C. S., Bolzonella, R., Bondar, N., Borgato, F., Borghi, S., Borsato, M., Borsuk, J. T., Bouchiba, S. A., Bowcock, T. J. V., Boyer, A., Bozzi, C., Bradley, M. J., Braun, S., Rodriguez, A. Brea, Breer, N., Brodzicka, J., Gonzalo, A. Brossa, Brown, J., Brundu, D., Buonaura, A., Buonincontri, L., Burke, A. T., Burr, C., Bursche, A., Butkevich, A., Butter, J. 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Subjects
High Energy Physics - Experiment
Abstract

The resonant structure of the radiative decay $\Lambda_b^0\to pK^-\gamma$ in the region of proton-kaon invariant-mass up to 2.5 GeV$/c^2$ is studied using proton-proton collision data recorded at centre-of-mass energies of 7, 8, and 13 TeV collected with the LHCb detector, corresponding to a total integrated luminosity of 9 fb$^{-1}$. Results are given in terms of fit and interference fractions between the different components contributing to this final state. Only $\Lambda$ resonances decaying to $pK^-$ are found to be relevant, where the largest contributions stem from the $\Lambda(1520)$, $\Lambda(1600)$, $\Lambda(1800)$, and $\Lambda(1890)$ states., Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-036.html (LHCb public pages)

Published
2024
Full Text
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241. First observation of the $\Lambda^0_b \to D^+ D^- \Lambda$ decay

Author

LHCb collaboration, Aaij, R., Abdelmotteleb, A. S. W., Beteta, C. Abellan, Abudinén, F., Ackernley, T., Adams, J. A., Adefisoye, A. A., Adeva, B., Adinolfi, M., Adlarson, P., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Aliouche, Z., Cartelle, P. Alvarez, Amalric, R., Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreianov, A., Andreola, P., Andreotti, M., Andreou, D., Anelli, A., Ao, D., Archilli, F., Argenton, M., Cuendis, S. Arguedas, Artamonov, A., Artuso, M., Aslanides, E., Atzeni, M., Audurier, B., Bacher, D., Perea, I. Bachiller, Bachmann, S., Bachmayer, M., Back, J. J., Rodriguez, P. Baladron, Balagura, V., Baldini, W., Leite, J. Baptista de Souza, Barbetti, M., Barbosa, I. R., Barlow, R. J., Barsuk, S., Barter, W., Bartolini, M., Bartz, J., Baryshnikov, F., Basels, J. M., Bassi, G., Batsukh, B., Battig, A., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I. 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M., Hammerich, J., Han, Q., Han, X., Hansmann-Menzemer, S., Hao, L., Harnew, N., Harrison, T., Hartmann, M., He, J., Heijhoff, K., Hemmer, F., Henderson, C., Henderson, R. D. L., Hennequin, A. M., Hennessy, K., Henry, L., Herd, J., Gascon, P. Herrero, Heuel, J., Hicheur, A., Mendizabal, G. Hijano, Hill, D., Hollitt, S. E., Horswill, J., Hou, R., Hou, Y., Howarth, N., Hu, J., Hu, W., Hu, X., Huang, W., Hulsbergen, W., Hunter, R. J., Hushchyn, M., Hutchcroft, D., Ilin, D., Ilten, P., Inglessi, A., Iniukhin, A., Ishteev, A., Ivshin, K., Jacobsson, R., Jage, H., Elles, S. J. Jaimes, Jakobsen, S., Jans, E., Jashal, B. K., Jawahery, A., Jevtic, V., Jiang, E., Jiang, X., Jiang, Y., Jiang, Y. J., John, M., Johnson, D., Jones, C. R., Jones, T. P., Joshi, S., Jost, B., Jurik, N., Juszczak, I., Kaminaris, D., Kandybei, S., Kang, Y., Karacson, M., Karpenkov, D., Kauniskangas, A., Kautz, J. W., Keizer, F., Kenzie, M., Ketel, T., Khanji, B., Kharisova, A., Kholodenko, S., Khreich, G., Kirn, T., Kirsebom, V. S., Kitouni, O., Klaver, S., Kleijne, N., Klimaszewski, K., Kmiec, M. R., Koliiev, S., Kolk, L., Konoplyannikov, A., Kopciewicz, P., Koppenburg, P., Korolev, M., Kostiuk, I., Kot, O., Kotriakhova, S., Kozachuk, A., Kravchenko, P., Kravchuk, L., Kreps, M., Kretzschmar, S., Krokovny, P., Krupa, W., Krzemien, W., Kubat, J., Kubis, S., Kucewicz, W., Kucharczyk, M., Kudryavtsev, V., Kulikova, E., Kupsc, A., Kutsenko, B. K., Lacarrere, D., Lai, A., Lampis, A., Lancierini, D., Gomez, C. Landesa, Lane, J. J., Lane, R., Langenbruch, C., Langer, J., Lantwin, O., Latham, T., Lazzari, F., Lazzeroni, C., Gac, R. Le, Lefèvre, R., Leflat, A., Legotin, S., Lehuraux, M., Cid, E. Lemos, Leroy, O., Lesiak, T., Leverington, B., Li, A., Li, H., Li, K., Li, L., Li, P., Li, P. -R., Li, S., Li, T., Li, Y., Li, Z., Lian, Z., Liang, X., Libralon, S., Lin, C., Lin, T., Lindner, R., Lisovskyi, V., Litvinov, R., Liu, F. L., Liu, G., Liu, K., Liu, Q., Liu, S., Liu, Y., Liu, Y. L., Salvia, A. Lobo, Loi, A., Castro, J. Lomba, Long, T., Lopes, J. H., Huertas, A. Lopez, Soliño, S. López, Lovell, G. H., Lucarelli, C., Lucchesi, D., Luchuk, S., Martinez, M. Lucio, Lukashenko, V., Luo, Y., Lupato, A., Luppi, E., Lynch, K., Lyu, X. -R., Ma, G. M., Ma, R., Maccolini, S., Machefert, F., Maciuc, F., Mack, B. M., Mackay, I., Mackey, L. M., Mohan, L. R. Madhan, Madurai, M. M., Maevskiy, A., Magdalinski, D., Maisuzenko, D., Majewski, M. W., Malczewski, J. J., Malde, S., Malecki, B., Malentacca, L., Malinin, A., Maltsev, T., Manca, G., Mancinelli, G., Mancuso, C., Escalero, R. Manera, Manuzzi, D., Marangotto, D., Marchand, J. F., Marchevski, R., Marconi, U., Mariani, S., Benito, C. Marin, Marks, J., Marshall, A. M., Marshall, P. J., Martelli, G., Martellotti, G., Martinazzoli, L., Martinelli, M., Santos, D. Martinez, Vidal, F. Martinez, Massafferri, A., Materok, M., Matev, R., Mathad, A., Matiunin, V., Matteuzzi, C., Mattioli, K. R., Mauri, A., Maurice, E., Mauricio, J., Mayencourt, P., Mazurek, M., McCann, M., Mcconnell, L., McGrath, T. H., McHugh, N. T., McNab, A., McNulty, R., Meadows, B., Meier, G., Melnychuk, D., Merk, M., Merli, A., Garcia, L. Meyer, Miao, D., Miao, H., Mikhasenko, M., Milanes, D. A., Minotti, A., Minucci, E., Miralles, T., Mitreska, B., Mitzel, D. S., Modak, A., Mödden, A., Mohammed, R. A., Moise, R. D., Mokhnenko, S., Mombächer, T., Monk, M., Monteil, S., Gomez, A. Morcillo, Morello, G., Morello, M. J., Morgenthaler, M. P., Morris, A. B., Morris, A. G., Mountain, R., Mu, H., Mu, Z. M., Muhammad, E., Muheim, F., Mulder, M., Müller, K., Muñoz-Rojas, F., Murta, R., Naik, P., Nakada, T., Nandakumar, R., Nanut, T., Nasteva, I., Needham, M., Neri, N., Neubert, S., Neufeld, N., Neustroev, P., Nicolini, J., Nicotra, D., Niel, E. M., Nikitin, N., Nogga, P., Nolte, N. S., Normand, C., Fernandez, J. Novoa, Nowak, G., Nunez, C., Nur, H. N., Oblakowska-Mucha, A., Obraztsov, V., Oeser, T., Okamura, S., Okhotnikov, A., Oldeman, R., Oliva, F., Olocco, M., Onderwater, C. J. G., O'Neil, R. H., Goicochea, J. M. Otalora, Owen, P., Oyanguren, A., Ozcelik, O., Padeken, K. O., Pagare, B., Pais, P. R., Pajero, T., Palano, A., Palutan, M., Panshin, G., Paolucci, L., Papanestis, A., Pappagallo, M., Pappalardo, L. L., Pappenheimer, C., Parkes, C., Passalacqua, B., Passaleva, G., Passaro, D., Pastore, A., Patel, M., Patoc, J., Patrignani, C., Pawley, C. J., Pellegrino, A., Altarelli, M. Pepe, Perazzini, S., Pereima, D., Castro, A. Pereiro, Perret, P., Perro, A., Petridis, K., Petrolini, A., Petrucci, S., Pfaller, J. P., Pham, H., Pica, L., Piccini, M., Pietrzyk, B., Pietrzyk, G., Pinci, D., Pisani, F., Pizzichemi, M., Placinta, V., Casasus, M. Plo, Polci, F., Lener, M. Poli, Poluektov, A., Polukhina, N., Polyakov, I., Polycarpo, E., Ponce, S., Popov, D., Poslavskii, S., Prasanth, K., Prouve, C., Pugatch, V., Punzi, G., Qian, W., Qin, N., Qu, S., Quagliani, R., Trejo, R. I. Rabadan, Rademacker, J. H., Rama, M., García, M. Ramírez, Pernas, M. Ramos, Rangel, M. S., Ratnikov, F., Raven, G., De Miguel, M. Rebollo, Redi, F., Reich, J., Reiss, F., Ren, Z., Resmi, P. K., Ribatti, R., Ricart, G. R., Riccardi, D., Ricciardi, S., Richardson, K., Richardson-Slipper, M., Rinnert, K., Robbe, P., Robertson, G., Rodrigues, E., Fernandez, E. Rodriguez, Lopez, J. A. Rodriguez, Rodriguez, E. Rodriguez, Rogovskiy, A., Rolf, D. L., Roloff, P., Romanovskiy, V., Lamas, M. Romero, Vidal, A. Romero, Romolini, G., Ronchetti, F., Rotondo, M., Roy, S. R., Rudolph, M. S., Ruf, T., Diaz, M. Ruiz, Fernandez, R. A. Ruiz, Vidal, J. Ruiz, Ryzhikov, A., Ryzka, J., Saavedra-Arias, J. J., Silva, J. J. Saborido, Sadek, R., Sagidova, N., Sahoo, D., Sahoo, N., Saitta, B., Salomoni, M., Gras, C. Sanchez, Sanderswood, I., Santacesaria, R., Rios, C. Santamarina, Santimaria, M., Santoro, L., Santovetti, E., Saputi, A., Saranin, D., Sarpis, G., Sarpis, M., Sarti, A., Satriano, C., Satta, A., Saur, M., Savrina, D., Sazak, H., Smead, L. G. Scantlebury, Scarabotto, A., Schael, S., Scherl, S., Schertz, A. M., Schiller, M., Schindler, H., Schmelling, M., Schmidt, B., Schmitt, S., Schmitz, H., Schneider, O., Schopper, A., Schulte, N., Schulte, S., Schune, M. H., Schwemmer, R., Schwering, G., Sciascia, B., Sciuccati, A., Sellam, S., Semennikov, A., Senger, T., Soares, M. Senghi, Sergi, A., Serra, N., Sestini, L., Seuthe, A., Shang, Y., Shangase, D. M., Shapkin, M., Sharma, R. S., Shchemerov, I., Shchutska, L., Shears, T., Shekhtman, L., Shen, Z., Sheng, S., Shevchenko, V., Shi, B., Shields, E. B., Shimizu, Y., Shmanin, E., Shorkin, R., Shupperd, J. D., Coutinho, R. Silva, Simi, G., Simone, S., Skidmore, N., Skwarnicki, T., Slater, M. W., Smallwood, J. C., Smith, E., Smith, K., Smith, M., Snoch, A., Lavra, L. Soares, Sokoloff, M. D., Soler, F. J. P., Solomin, A., Solovev, A., Solovyev, I., Song, R., Song, Y., Song, Y. S., De Almeida, F. L. Souza, De Paula, B. Souza, Norella, E. Spadaro, Spedicato, E., Speer, J. G., Spiridenkov, E., Spradlin, P., Sriskaran, V., Stagni, F., Stahl, M., Stahl, S., Stanislaus, S., Stein, E. N., Steinkamp, O., Stenyakin, O., Stevens, H., Strekalina, D., Su, Y., Suljik, F., Sun, J., Sun, L., Sun, Y., Sutcliffe, W., Swallow, P. N., Swystun, F., Szabelski, A., Szumlak, T., Tan, Y., Taneja, S., Tat, M. D., Terentev, A., Terzuoli, F., Teubert, F., Thomas, E., Thompson, D. J. D., Tilquin, H., Tisserand, V., T'Jampens, S., Tobin, M., Tomassetti, L., Tonani, G., Tong, X., Machado, D. Torres, Toscano, L., Tou, D. Y., Trippl, C., Tuci, G., Tuning, N., Uecker, L. H., Ukleja, A., Unverzagt, D. J., Ursov, E., Usachov, A., Ustyuzhanin, A., Uwer, U., Vagnoni, V., Valassi, A., Valenti, G., Canudas, N. Valls, Van Hecke, H., van Herwijnen, E., Van Hulse, C. B., Van Laak, R., van Veghel, M., Gomez, R. Vazquez, Regueiro, P. Vazquez, Sierra, C. Vázquez, Vecchi, S., Velthuis, J. J., Veltri, M., Venkateswaran, A., Vesterinen, M., Diaz, M. Vieites, Vilasis-Cardona, X., Figueras, E. Vilella, Villa, A., Vincent, P., Volle, F. C., Bruch, D. vom, Vorobyev, V., Voropaev, N., Vos, K., Vouters, G., Vrahas, C., Wagner, J., Walsh, J., Walton, E. J., Wan, G., Wang, C., Wang, G., Wang, J., Wang, M., Wang, N. W., Wang, R., Wang, X., Wang, X. W., Wang, Y., Wang, Z., Ward, J. A., Waterlaat, M., Watson, N. K., Websdale, D., Wei, Y., Westhenry, B. D. C., White, D. J., Whitehead, M., Wiederhold, A. R., Wiedner, D., Wilkinson, G., Wilkinson, M. K., Williams, M., Williams, M. R. J., Williams, R., Wilson, F. F., Wislicki, W., Witek, M., Witola, L., Wong, C. P., Wormser, G., Wotton, S. A., Wu, H., Wu, J., Wu, Y., Wyllie, K., Xian, S., Xiang, Z., Xie, Y., Xu, A., Xu, J., Xu, L., Xu, M., Xu, Z., Yang, D., Yang, S., Yang, X., Yang, Y., Yang, Z., Yeroshenko, V., Yeung, H., Yin, H., Yu, C. Y., Yu, J., Yuan, X., Zaffaroni, E., Zavertyaev, M., Zdybal, M., Zeng, M., Zhang, C., Zhang, D., Zhang, J., Zhang, L., Zhang, S., Zhang, Y., Zhang, Y. Z., Zhao, Y., Zharkova, A., Zhelezov, A., Zheng, X. Z., Zheng, Y., Zhou, T., Zhou, X., Zhou, Y., Zhovkovska, V., Zhu, L. Z., Zhu, X., Zhukov, V., Zhuo, J., Zou, Q., Zuliani, D., and Zunica, G.

Subjects
High Energy Physics - Experiment
Abstract

The $\Lambda^0_b \to D^+ D^- \Lambda$ decay is observed for the first time using proton-proton collision data collected by the LHCb experiment at a center-of-mass energy of $13 \mathrm{TeV}$, corresponding to an integrated luminosity of $5.3 \mathrm{fb}^{-1}$. Using the $B^0 \to D^+ D^- K_{\mathrm{S}}^0$ decay as a reference channel, the product of the relative production cross-section and decay branching fractions is measured to be $$ {\cal R}=\frac{\sigma_{\Lambda^0_b}}{\sigma_{B^0}} \times \frac{{\cal B}(\Lambda^0_b \to D^+ D^- \Lambda)}{{\cal B}(B^0 \to D^+ D^- K_{\mathrm{S}}^0)}=0.179 \pm 0.022 \pm 0.014 $$ where the first uncertainty is statistical and the second is systematic. The known branching fraction of the reference channel, ${\cal B}(B^0 \to D^+ D^- K_{\mathrm{S}}^0)$, and the cross-section ratio, $\sigma_{\Lambda^0_b} / \sigma_{B^0}$, previously measured by $\mathrm{LHCb}$ are used to derive the branching fraction of the $\Lambda^0_b \to D^+ D^- \Lambda$ decay $$ {\cal B}(\Lambda^0_b \to D^+ D^- \Lambda)=(1.24 \pm 0.15 \pm 0.10 \pm 0.28 \pm 0.11) \times 10^{-4}, $$ where the third and fourth contributions are due to uncertainties of ${\cal B}(B^0 \to D^+ D^- K_{\mathrm{S}}^0)$ and $\sigma_{\Lambda^0_b} / \sigma_{B^0}$, respectively. Inspection of the $D^+ \Lambda$ and $D^+ D^-$ invariant-mass distributions suggests a rich presence of intermediate resonances in the decay. The $\Lambda^0_b \to D^{*+} D^- \Lambda$ decay is also observed for the first time as a partially reconstructed component in the $D^+ D^- \Lambda$ invariant mass spectrum., Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-042.html (LHCb public pages)

Published
2024
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242. Acceptability and Feasibility of Using Hair Samples for Chronic Stress Measurement Among Transgender Women in Brazil

Author

Zamudio‐Haas, Sophia, de Carvalho, Paula Galdino Cardin, Marr, Alexander, Mocelle, A Rain, Moscatelli, Antonio, Bassichetto, Katia Cristina, Santa Roza Saggese, Gustavo, Prado, Patric V, Gerona, Roy, Lippman, Sheri A, Veras, Maria Amélia, and Sevelius, Jae M

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Sexual and Gender Minorities (SGM/LGBT*), Behavioral and Social Science, Clinical Research, Mental Health, Prevention, Humans, Female, Transgender Persons, Hair, Adult, Feasibility Studies, Brazil, Stress, Psychological, Hydrocortisone, Male, Young Adult, Middle Aged, Adolescent, LGBT health, stress measurement, transgender women
Abstract

IntroductionThe ability to objectively measure chronic stress has important implications for research, prevention, and treatment. Cortisol is currently the most used biological marker in the investigation of stress and can be measured via blood, saliva, and urine; however, these methods have disadvantages. The measurement of cortisol in hair is a more recently developed method that quantifies the cumulative production of cortisol over longer periods of time. Given the potential benefits of hair as a chronic stress biometric, research with this novel method is burgeoning, yet rarely involves transgender ("trans") populations, despite high levels of reported stress among trans people due to experiences of stigma and discrimination. Since hair is a key part of gender presentation, trans people might be less likely than cisgender people to donate hair for research. To explore the feasibility and acceptability of hair collection for use as a stress biometric with trans women, we nested a study into an ongoing clinical trial in São Paulo, Brazil, "Manas por Manas" (Sisters for Sisters). Here, we describe the hair biometric substudy protocol, as well as the feasibility and acceptability of collecting hair in the study cohort.MethodsWe randomly selected a subsample (n = 180) from the Manas por Manas cohort (n = 392), all of whom are trans women, age 18 or older. We messaged participants via phone, WhatsApp, or social media for at least three attempted contacts. Study visits included four components: (1) video introduction, including a demonstration of hair sampling; (2) informed consent; (3) a brief survey with the validated Short Stress Overload Scale (translated to Portuguese) and questions on hair care that could moderate stress hormone results; and (4) hair sample collection. Hair samples were collected and stored using validated protocols. Participants were reimbursed for travel costs.ResultsBetween April and December 2022, we messaged with 143 individuals out of the 180 sampled (79%) and invited them to participate in the study. Of those invited to participate, we scheduled study visits with 102 people (71.3% of those invited to participate), of whom 100 attended their study visits and completed all activities. Two people did not attend their study visits and stopped communication. Of those who were invited to participate and declined a study visit, four individuals declined due to the hair sample collection procedures (2.8% of those invited to participate). Other reasons for declining to participate included having moved (n = 7), lack of time (n = 11), not interested in research participation (n = 8), or unknown/stopped responding to messages (n = 11). Most participants reported that they chemically treated their hair to bleach, color, or straighten it, which could impact laboratory assays.ConclusionWe found hair sampling for stress measurement to be feasible and acceptable to our participants. We successfully completed all study activities for our desired sample size, and most recruited individuals volunteered to participate. Reasons provided for declining study participation reflected general barriers to research participation, with only four people declining due to hair sample collection procedures.

Published
2024

243. Adjuvant Trastuzumab Emtansine Versus Paclitaxel Plus Trastuzumab for Stage I Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: 5-Year Results and Correlative Analyses From ATEMPT.

Author

Tarantino, Paolo, Tayob, Nabihah, Villacampa, Guillermo, Dang, Chau, Yardley, Denise, Isakoff, Steven, Valero, Vicente, Faggen, Meredith, Mulvey, Therese, Bose, Ron, Weckstein, Douglas, Wolff, Antonio, Reeder-Hayes, Katherine, Rugo, Hope, Ramaswamy, Bhuvaneswari, Zuckerman, Dan, Hart, Lowell, Gadi, Vijayakrishna, Constantine, Michael, Cheng, Kit, Garrett, Audrey, Marcom, P, Albain, Kathy, DeFusco, Patricia, Tung, Nadine, Ardman, Blair, Nanda, Rita, Jankowitz, Rachel, Rimawi, Mothaffar, Abramson, Vandana, Pohlmann, Paula, Van Poznak, Catherine, Forero-Torres, Andres, Liu, Minetta, Ruddy, Kathryn, Waks, Adrienne, DeMeo, Michelle, Burstein, Harold, Partridge, Ann, DellOrto, Patrizia, Russo, Leila, Krause, Emma, Newhouse, Daniel, Kurt, Busem, Mittendorf, Elizabeth, Schneider, Bryan, Prat, Aleix, Winer, Eric, Krop, Ian, and Tolaney, Sara

Subjects
Humans, Female, Breast Neoplasms, Receptor, ErbB-2, Paclitaxel, Ado-Trastuzumab Emtansine, Middle Aged, Antineoplastic Combined Chemotherapy Protocols, Trastuzumab, Chemotherapy, Adjuvant, Adult, Neoplasm Staging, Aged, Disease-Free Survival
Abstract

PURPOSE: Long-term outcomes of patients with stage I human epidermal growth factor receptor 2 (HER2)-positive breast cancer receiving adjuvant trastuzumab emtansine (T-DM1) remain undefined, and prognostic predictors represent an unmet need. METHODS: In the ATEMPT phase II trial, patients with stage I centrally confirmed HER2-positive breast cancer were randomly assigned 3:1 to adjuvant T-DM1 for 1 year or paclitaxel plus trastuzumab (TH). Coprimary objectives were to compare the incidence of clinically relevant toxicities between arms and to evaluate invasive disease-free survival (iDFS) with T-DM1. Correlative analyses included the HER2DX genomic tool, multiomic evaluations of HER2 heterogeneity, and predictors of thrombocytopenia. RESULTS: After a median follow-up of 5.8 years, 11 iDFS events were observed in the T-DM1 arm, consistent with a 5-year iDFS of 97.0% (95% CI, 95.2 to 98.7). At 5 years, the recurrence-free interval (RFI) was 98.3% (95% CI, 97.0 to 99.7), the overall survival was 97.8% (95% CI, 96.3 to 99.3), and the breast cancer-specific survival was 99.4% (95% CI, 98.6 to 100). Comparable iDFS was observed with T-DM1 irrespective of tumor size, hormone receptor status, centrally determined HER2 immunohistochemical score, and receipt of T-DM1 for more or less than 6 months. Although ATEMPT was not powered for this end point, the 5-year iDFS in the TH arm was 91.1%. Among patients with sufficient tissue for HER2DX testing (n = 187), 5-year outcomes significantly differed according to HER2DX risk score, with better RFI (98.1% v 81.8%, hazard ratio [HR], 0.10, P = .01) and iDFS (96.3% v 81.8%, HR, 0.20, P = .047) among patients with HER2DX low-risk versus high-risk tumors, respectively. CONCLUSION: Adjuvant T-DM1 for 1 year leads to outstanding long-term outcomes for patients with stage I HER2-positive breast cancer. A high HER2DX risk score predicted a higher risk of recurrence in ATEMPT.

Published
2024

244. CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors.

Author

Skoulidis, Ferdinandos, Araujo, Haniel, Do, Minh, Qian, Yu, Sun, Xin, Cobo, Ana, Le, John, Montesion, Meagan, Palmer, Rachael, Jahchan, Nadine, Juan, Joseph, Min, Chengyin, Yu, Yi, Pan, Xuewen, Arbour, Kathryn, Vokes, Natalie, Schmidt, Stephanie, Molkentine, David, Owen, Dwight, Memmott, Regan, Patil, Pradnya, Marmarelis, Melina, Awad, Mark, Murray, Joseph, Hellyer, Jessica, Gainor, Justin, Dimou, Anastasios, Bestvina, Christine, Shu, Catherine, Riess, Jonathan, Blakely, Collin, Pecot, Chad, Mezquita, Laura, Tabbó, Fabrizio, Scheffler, Matthias, Digumarthy, Subba, Mooradian, Meghan, Sacher, Adrian, Lau, Sally, Saltos, Andreas, Rotow, Julia, Johnson, Rocio, Liu, Corinne, Stewart, Tyler, Goldberg, Sarah, Killam, Jonathan, Walther, Zenta, Schalper, Kurt, Davies, Kurtis, Woodcock, Mark, Anagnostou, Valsamo, Marrone, Kristen, Forde, Patrick, Ricciuti, Biagio, Venkatraman, Deepti, Van Allen, Eliezer, Cummings, Amy, Goldman, Jonathan, Shaish, Hiram, Kier, Melanie, Katz, Sharyn, Aggarwal, Charu, Ni, Ying, Azok, Joseph, Segal, Jeremy, Ritterhouse, Lauren, Neal, Joel, Lacroix, Ludovic, Elamin, Yasir, Negrao, Marcelo, Le, Xiuning, Lam, Vincent, Lewis, Whitney, Kemp, Haley, Carter, Brett, Roth, Jack, Swisher, Stephen, Lee, Richard, Zhou, Teng, Poteete, Alissa, Kong, Yifan, Takehara, Tomohiro, Paula, Alvaro, Parra Cuentas, Edwin, Behrens, Carmen, Wistuba, Ignacio, Zhang, Jianjun, Blumenschein, George, Gay, Carl, Byers, Lauren, Gibbons, Don, Tsao, Anne, Lee, J, Bivona, Trever, Camidge, D, Gray, Jhannelle, Lieghl, Natasha, Levy, Benjamin, Brahmer, Julie, and Garassino, Marina

Subjects
Animals, Female, Humans, Male, Mice, AMP-Activated Protein Kinase Kinases, Antibodies, Monoclonal, B7-H1 Antigen, Carcinoma, Non-Small-Cell Lung, Clinical Trials, Phase III as Topic, CTLA-4 Antigen, Drug Resistance, Neoplasm, Immune Checkpoint Inhibitors, Kelch-Like ECH-Associated Protein 1, Lung Neoplasms, Mutation, Nitric Oxide Synthase Type II, T-Lymphocytes, Tumor Microenvironment, Tumor Suppressor Proteins, Genes, Tumor Suppressor
Abstract

For patients with advanced non-small-cell lung cancer (NSCLC), dual immune checkpoint blockade (ICB) with CTLA4 inhibitors and PD-1 or PD-L1 inhibitors (hereafter, PD-(L)1 inhibitors) is associated with higher rates of anti-tumour activity and immune-related toxicities, when compared with treatment with PD-(L)1 inhibitors alone. However, there are currently no validated biomarkers to identify which patients will benefit from dual ICB1,2. Here we show that patients with NSCLC who have mutations in the STK11 and/or KEAP1 tumour suppressor genes derived clinical benefit from dual ICB with the PD-L1 inhibitor durvalumab and the CTLA4 inhibitor tremelimumab, but not from durvalumab alone, when added to chemotherapy in the randomized phase III POSEIDON trial3. Unbiased genetic screens identified loss of both of these tumour suppressor genes as independent drivers of resistance to PD-(L)1 inhibition, and showed that loss of Keap1 was the strongest genomic predictor of dual ICB efficacy-a finding that was confirmed in several mouse models of Kras-driven NSCLC. In both mouse models and patients, KEAP1 and STK11 alterations were associated with an adverse tumour microenvironment, which was characterized by a preponderance of suppressive myeloid cells and the depletion of CD8+ cytotoxic T cells, but relative sparing of CD4+ effector subsets. Dual ICB potently engaged CD4+ effector cells and reprogrammed the tumour myeloid cell compartment towards inducible nitric oxide synthase (iNOS)-expressing tumoricidal phenotypes that-together with CD4+ and CD8+ T cells-contributed to anti-tumour efficacy. These data support the use of chemo-immunotherapy with dual ICB to mitigate resistance to PD-(L)1 inhibition in patients with NSCLC who have STK11 and/or KEAP1 alterations.

Published
2024

245. Exploring Youths Offers to Use E-Cigarettes in Rural Hawaii: A Test Development and Validation Study.

Author

Okamoto, Scott, Subica, Andrew, Okamura, Kelsie, An, Katlyn, Song, Sarah, Saladino, Paula, Carson, Adabelle, Kon, Zarek, Marshall, Sarah, Chin, Steven, Kaholokula, Joseph, Pagano, Ian, and Pokhrel, Pallav

Subjects
Native Hawaiian, Pacific Islander, e-cigarette, test development, youth, Humans, Adolescent, Hawaii, Rural Population, Male, Female, Electronic Nicotine Delivery Systems, Surveys and Questionnaires, Native Hawaiian or Other Pacific Islander, Vaping, Child, Focus Groups
Abstract

The purpose of this study is to describe the development and initial validation of a survey focused on problematic situations involving e-cigarette use by rural Native Hawaiian and Pacific Islander (NHPI) youths. A 5-phase approach to test development and validation was used. In Phase 1 (Item Generation), survey items were created from a series of focus groups with middle school youths on Hawaii Island (N = 69). In Phase 2 (Item Refinement and Selection), situational items were reduced to 40 e-cigarette offer situations that were selected for inclusion in the survey. In Phase 3 (Item Reduction), items were administered to 257 youths from 11 middle, intermediate, or multi-level public or public-charter schools on Hawaii Island. Exploratory factor analysis indicated the presence of three factors accounting for 50% of the variance: E-Cigarette Offers from Friends (24%), E-Cigarette Offers from Non-Friends (16%), and Coercive Pressure to Use E-Cigarettes (10%). Hypothesized relationships between offer situations and e-cigarette use were partially confirmed, supporting the construct validity of the survey. This survey helps to fill the scientific and practice gap in measuring ecodevelopmental risk and protection for e-cigarette use and has implications for e-cigarette use prevention with rural, NHPI, and/or Indigenous youth populations.

Published
2024

246. The DESI Early Data Release white dwarf catalogue

Author

Manser, Christopher J, Izquierdo, Paula, Gänsicke, Boris T, Swan, Andrew, Koester, Detlev, Robert, Akshay, Xu, Siyi, Inight, Keith, Amroota, Ben, Fusillo, NP Gentile, Koposov, Sergey E, Kim, Bokyoung, Dey, Arjun, Prieto, Carlos Allende, Aguilar, J, Ahlen, S, Blum, R, Brooks, D, Claybaugh, T, Cooper, AP, Dawson, K, de la Macorra, A, Doel, P, Forero-Romero, JE, Gaztañaga, E, Gontcho, S Gontcho A, Honscheid, K, Kisner, T, Kremin, A, Lambert, A, Landriau, M, Le Guillou, L, Levi, Michael E, Li, TS, Meisner, A, Miquel, R, Moustakas, J, Nie, J, Palanque-Delabrouille, N, Percival, WJ, Poppett, C, Prada, F, Rezaie, M, Rossi, G, Sanchez, E, Schlafly, EF, Schlegel, D, Schubnell, M, Seo, H, Silber, J, Tarlé, G, Weaver, BA, Zhou, Z, and Zou, H

Subjects
Astronomical Sciences, Physical Sciences, techniques: spectroscopic, catalogues, surveys, white dwarfs, Astronomical and Space Sciences, Astronomy & Astrophysics, Astronomical sciences, Particle and high energy physics, Space sciences
Abstract

The Early Data Release (EDR) of the Dark Energy Spectroscopic Instrument (DESI) comprises spectroscopy obtained from 2020 December 14 to 2021 June 10. White dwarfs were targeted by DESI both as calibration sources and as science targets and were selected based on Gaia photometry and astrometry. Here, we present the DESI EDR white dwarf catalogue, which includes 2706 spectroscopically confirmed white dwarfs of which approximately 60 per cent have been spectroscopically observed for the first time, as well as 66 white dwarf binary systems. We provide spectral classifications for all white dwarfs, and discuss their distribution within the Gaia Hertzsprung–Russell diagram. We provide atmospheric parameters derived from spectroscopic and photometric fits for white dwarfs with pure hydrogen or helium photospheres, a mixture of those two, and white dwarfs displaying carbon features in their spectra. We also discuss the less abundant systems in the sample, such as those with magnetic fields, and cataclysmic variables. The DESI EDR white dwarf sample is significantly less biased than the sample observed by the Sloan Digital Sky Survey, which is skewed to bluer and therefore hotter white dwarfs, making DESI more complete and suitable for performing statistical studies of white dwarfs.

Published
2024

247. Impact of an individualized pain plan to treat sickle cell disease vaso-occlusive episodes in the emergency department.

Author

Siewny, Lauren, King, Allison, Melvin, Cathy, Carpenter, Christopher, Hankins, Jane, Colla, Joseph, Preiss, Liliana, Luo, Lingzi, Cox, Lisa, Treadwell, Marsha, Davila, Natalia, Masese, Rita, McCuskee, Sarah, Gollan, S, and Tanabe, Paula

Subjects
Humans, Anemia, Sickle Cell, Female, Emergency Service, Hospital, Male, Adult, Pain Management, Adolescent, Young Adult, Middle Aged, Pain
Abstract

To address acute vaso-occlusive episodes (VOEs), the leading cause of emergency department (ED) visits among individuals with sickle cell disease (SCD), we conducted the clinical study, ALIGN (An Individualized Pain Plan with Patient and Provider Access for Emergency Department care of SCD), across 8 sites. We hypothesized an improvement of 0.5 standard deviations in perceived quality of ED pain treatment of a VOE after implementing individualized pain plans (IPPs) accessible to both patients and providers. Patients with SCD were aged 18 to 45 years, owned a cell phone, and had an ED VOE visit within 90 days prior. Patients completed the perceived quality of care surveys at baseline and within 96 hours after an ED VOE visit. Providers completed surveys regarding comfort managing VOEs at baseline and after managing an enrolled patient. Most of the 153 patients were African American (95.4%), female (64.7%), and had Hb SS/Sβ0 genotype (71.9%). The perceived quality of ED pain treatment was high at both baseline and after implementation of IPPs; our primary outcome hypothesis was not met, because no statistically significant change in the patient-perceived quality of ED treatment occurred. A total of 135 providers completed baseline and follow-up surveys. On a scale of 1 to 7, with 7 being extremely comfortable managing VOEs, 60.5% reported a score ≥6 after IPP implementation vs 57.8% at baseline. Almost all (97.6%) ordered the recommended medication, and 94.7% intended to use IPPs. In this implementation protocol, all sites successfully implemented IPPs. Patients and ED providers both endorsed the use of IPPs. This trial was registered at www.ClinicalTrials.gov as # NCT04584528.

Published
2024

248. Increasing goals of care conversations in primary care: Study protocol for a cluster randomized, pragmatic, sequential multiple assignment randomized trial.

Author

Bekelman, David, Giannitrapani, Karleen, Linn, Kristin, Langner, Paula, Sudore, Rebecca, Rabin, Borsika, Lorenz, Karl, Foglia, Marybeth, Glickman, Amanda, Pawlikowski, Scott, Sloan, Marilyn, Gamboa, Raziel, McCaa, Matthew, Hines, Anne, and Walling, Anne

Subjects
Advance care planning, Goals of care conversations, Implementation science, Palliative care, Quality of life, Sequential multiple assignment randomized trial (SMART), Serious illness conversations, Humans, Primary Health Care, United States Department of Veterans Affairs, Patient Care Planning, United States, Communication, Physician-Patient Relations
Abstract

BACKGROUND: Goals of care conversations explore seriously ill patients values to guide medical decision making and often inform decisions about life sustaining treatments. Ideally, conversations occur before a health crisis between patients and clinicians in the outpatient setting. In the United States Veterans Affairs (VA) healthcare system, most conversations still occur in the inpatient setting. Strategies are needed to improve implementation of outpatient, primary care goals of care conversations. METHODS: We plan a cluster randomized (clinician-level) sequential, multiple assignment randomized trial to evaluate the effectiveness of patient implementation strategies on the outcome of goals of care conversation documentation when delivered in combination with clinician implementation strategies. Across three VA healthcare system sites, we will enroll primary care clinicians with low rates of goals of care conversations and their patients with serious medical illness in the top 10th percentile of risk of hospitalization or death. We will compare the effectiveness of sequences of implementation strategies and explore how patient and site factors modify implementation strategy effects. Finally, we will conduct a mixed-methods evaluation to understand implementation strategy success or failure. The design includes two key innovations: (1) strategies that target both clinicians and patients and (2) sequential strategies with increased intensity for non-responders. CONCLUSION: This study aims to determine the effect of different sequences and combinations of implementation strategies on primary care documentation of goals of care conversations. Study partners, including the VA National Center for Ethics in Health Care and Office of Primary Care, can consider policies based on study findings.

Published
2024

249. Consequences of Social Policy on Creating a Homeless Population in the Oakland Area and Resulting Health Disparities for Older Adults

Author

Hsiao, Paula, Wahab, Asim, Hwang, Jay, and Bindra, Melina

Abstract

California has the largest homeless population in the nation, with a significant gap between the demand and supply of affordable housing. This disparity not only undermines the quality of life and educational opportunities for residents but also poses grave health risks. This study investigates the nexus between social policies and homelessness in California. By analyzing systemic factors such as exorbitant housing costs and inadequate social safety nets, we uncover the root causes of housing instability. Our examination extends to exploring the multifaceted health disparities experienced by homeless individuals, particularly older adults, and elucidating the complex interplay of mental health struggles within this demographic. Findings reveal that prevailing social policies significantly contribute to homelessness, exacerbating health inequities among vulnerable populations. Our analysis stresses the urgent need for evidence-based policy reforms and holistic, community-based approaches to address homelessness effectively and promote health equity.

Published
2024

250. Datopotamab–deruxtecan plus durvalumab in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial

Author

Shatsky, Rebecca A, Trivedi, Meghna S, Yau, Christina, Nanda, Rita, Rugo, Hope S, Davidian, Marie, Tsiatis, Butch, Wallace, Anne M, Chien, A Jo, Stringer-Reasor, Erica, Boughey, Judy C, Omene, Coral, Rozenblit, Mariya, Kalinsky, Kevin, Elias, Anthony D, Vaklavas, Christos, Beckwith, Heather, Williams, Nicole, Arora, Mili, Nangia, Chaitali, Roussos Torres, Evanthia T, Thomas, Brittani, Albain, Kathy S, Clark, Amy S, Falkson, Carla, Hershman, Dawn L, Isaacs, Claudine, Thomas, Alexandra, Tseng, Jennifer, Sanford, Amy, Yeung, Kay, Boles, Sarah, Chen, Yunni Yi, Huppert, Laura, Jahan, Nusrat, Parker, Catherine, Giridhar, Karthik, Howard, Frederick M, Blackwood, M Michele, Sanft, Tara, Li, Wen, Onishi, Natsuko, Asare, Adam L, Beineke, Philip, Norwood, Peter, Brown-Swigart, Lamorna, Hirst, Gillian L, Matthews, Jeffrey B, Moore, Brian, Symmans, W Fraser, Price, Elissa, Heditsian, Diane, LeStage, Barbara, Perlmutter, Jane, Pohlmann, Paula, DeMichele, Angela, Yee, Douglas, van ’t Veer, Laura J, Hylton, Nola M, and Esserman, Laura J

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Clinical Trials and Supportive Activities, Precision Medicine, Women's Health, Cancer, Clinical Research, Breast Cancer, 6.1 Pharmaceuticals, Good Health and Well Being, Medical and Health Sciences, Immunology, Biomedical and clinical sciences, Health sciences
Abstract

Sequential adaptive trial designs can help accomplish the goals of personalized medicine, optimizing outcomes and avoiding unnecessary toxicity. Here we describe the results of incorporating a promising antibody-drug conjugate, datopotamab-deruxtecan (Dato-DXd) in combination with programmed cell death-ligand 1 inhibitor, durvalumab, as the first sequence of therapy in the I-SPY2.2 phase 2 neoadjuvant sequential multiple assignment randomization trial for high-risk stage 2/3 breast cancer. The trial includes three blocks of treatment, with initial randomization to different experimental agent(s) (block A), followed by a taxane-based regimen tailored to tumor subtype (block B), followed by doxorubicin-cyclophosphamide (block C). Subtype-specific algorithms based on magnetic resonance imaging volume change and core biopsy guide treatment redirection after each block, including the option of early surgical resection in patients predicted to have a high likelihood of pathologic complete response, which is the primary endpoint assessed when resection occurs. There are two primary efficacy analyses: after block A and across all blocks for six prespecified HER2-negative subtypes (defined by hormone receptor status and/or response-predictive subtypes). In total, 106 patients were treated with Dato-DXd/durvalumab in block A. In the immune-positive subtype, Dato-DXd/durvalumab exceeded the prespecified threshold for success (graduated) after block A; and across all blocks, pathologic complete response rates were equivalent to the rate expected for the standard of care (79%), but 54% achieved that result after Dato-DXd/durvalumab alone (block A) and 92% without doxorubicin-cyclophosphamide (after blocks A + B). The treatment strategy across all blocks graduated in the hormone-negative/immune-negative subtype. No new toxicities were observed. Stomatitis was the most common side effect in block A. No patients receiving block A treatment alone had adrenal insufficiency. Dato-DXd/durvalumab is a promising therapy combination that can eliminate standard chemotherapy in many patients, particularly the immune-positive subtype.ClinicalTrials.gov registration: NCT01042379 .

Published
2024

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