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201. Pre-Operative Kidney Biomarkers and Risks for Death, Cardiovascular and Chronic Kidney Disease Events after Cardiac Surgery: The TRIBE-AKI Study

Author

Parikh, Chirag R., primary, Vasquez-Rios, George, additional, Moledina, Dennis G., additional, Jia, Yaqi, additional, McArthur, Eric, additional, Mansour, Sherry G., additional, Thiessen-Philbrook, Heather, additional, Shlipak, Michael G., additional, Koyner, Jay L., additional, Garg, Amit X., additional, and Coca, Steven G., additional

Published
2022
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202. Clinically adjudicated deceased donor acute kidney injury and graft outcomes

Author

Mansour, Sherry G., primary, Khoury, Nadeen, additional, Kodali, Ravi, additional, Virmani, Sarthak, additional, Reese, Peter P., additional, Hall, Isaac E., additional, Jia, Yaqi, additional, Yamamoto, Yu, additional, Thiessen-Philbrook, Heather R., additional, Obeid, Wassim, additional, Doshi, Mona D., additional, Akalin, Enver, additional, Bromberg, Jonathan S., additional, Harhay, Meera N., additional, Mohan, Sumit, additional, Muthukumar, Thangamani, additional, Singh, Pooja, additional, Weng, Francis L., additional, Moledina, Dennis G., additional, Greenberg, Jason H., additional, Wilson, Francis P., additional, and Parikh, Chirag R., additional

Published
2022
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204. Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy

Author

Baker, Megan L, primary, Yamamoto, Yu, additional, Perazella, Mark A, additional, Dizman, Nazli, additional, Shirali, Anushree C, additional, Hafez, Navid, additional, Weinstein, Jason, additional, Simonov, Michael, additional, Testani, Jeffrey M, additional, Kluger, Harriet M, additional, Cantley, Lloyd G, additional, Parikh, Chirag R, additional, Wilson, F Perry, additional, and Moledina, Dennis G, additional

Published
2022
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205. Prognostic Significance of Urinary Biomarkers in Patients Hospitalized With COVID-19

Author

Menez, Steven, primary, Moledina, Dennis G., additional, Thiessen-Philbrook, Heather, additional, Wilson, F. Perry, additional, Obeid, Wassim, additional, Simonov, Michael, additional, Yamamoto, Yu, additional, Corona-Villalobos, Celia P., additional, Chang, Crystal, additional, Garibaldi, Brian T., additional, Clarke, William, additional, Farhadian, Shelli, additional, Dela Cruz, Charles, additional, Coca, Steven G., additional, Parikh, Chirag R., additional, Ko, Albert, additional, Iwasaki, Akiko, additional, Nelson, Allison, additional, Casanovas-Massana, Arnau, additional, White, Elizabeth B., additional, Schulz, Wade, additional, Coppi, Andreas, additional, Young, Patrick, additional, Nunez, Angela, additional, Shepard, Denise, additional, Matos, Irene, additional, Strong, Yvette, additional, Anastasio, Kelly, additional, Brower, Kristina, additional, Kuang, Maxine, additional, Chiorazzi, Michael, additional, Bermejo, Santos, additional, Vijayakumar, Pavithra, additional, Geng, Bertie, additional, Fournier, John, additional, Minasyan, Maksym, additional, Muenker, M. Catherine, additional, Moore, Adam J., additional, and Nadkarni, Girish, additional

Published
2022
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206. Association between TNF Receptors and KIM-1 with Kidney Outcomes in Early-Stage Diabetic Kidney Disease

Author

Waijer, Simke W., primary, Sen, Taha, additional, Arnott, Clare, additional, Neal, Bruce, additional, Kosterink, Jos G.W., additional, Mahaffey, Kenneth W., additional, Parikh, Chirag R., additional, de Zeeuw, Dick, additional, Perkovic, Vlado, additional, Neuen, Brendon L., additional, Coca, Steven G., additional, Hansen, Michael K., additional, Gansevoort, Ron T., additional, and Heerspink, Hiddo J.L., additional

Published
2022
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207. Additional file 1 of Absence of long-term changes in urine biomarkers after AKI: findings from the CRIC study

Author

McCoy, Ian E., Hsu, Jesse Y., Bonventre, Joseph V., Parikh, Chirag R., Go, Alan S., Liu, Kathleen D., Ricardo, Ana C., Srivastava, Anand, Cohen, Debbie L., He, Jiang, Chen, Jing, Rao, Panduranga S., Muiru, Anthony N., and Hsu, Chi-yuan

Abstract

Additional file 1: Table S1. Raw urine biomarker levels without normalization to urine creatinine. Table S2. Urine biomarker-to-creatinine ratio changes in mixed effects models by AKI stage.

Published
2022
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209. Overcoming barriers in the design and implementation of clinical trials for acute kidney injury: a report from the 2020 Kidney Disease Clinical Trialists meeting

Author

Lazzareschi, Daniel, primary, Mehta, Ravindra L, additional, Dember, Laura M, additional, Bernholz, Juliane, additional, Turan, Alparslan, additional, Sharma, Amit, additional, Kheterpal, Sachin, additional, Parikh, Chirag R, additional, Ali, Omar, additional, Schulman, Ivonne H, additional, Ryan, Abigail, additional, Feng, Jean, additional, Simon, Noah, additional, Pirracchio, Romain, additional, Rossignol, Patrick, additional, and Legrand, Matthieu, additional

Published
2022
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210. Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs

Author

Won, Taejoon, primary, Wood, Megan K., additional, Hughes, David M., additional, Talor, Monica V., additional, Ma, Zexu, additional, Schneider, Jowaly, additional, Skinner, John T., additional, Asady, Beejan, additional, Goerlich, Erin, additional, Halushka, Marc K., additional, Hays, Allison G., additional, Kim, Deok-Ho, additional, Parikh, Chirag R., additional, Rosenberg, Avi Z., additional, Coppens, Isabelle, additional, Johns, Roger A., additional, Gilotra, Nisha A., additional, Hooper, Jody E., additional, Pekosz, Andrew, additional, and Čiháková, Daniela, additional

Published
2022
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212. Association of Surge Conditions with Mortality Among Critically Ill Patients with COVID-19

Author

Keene, Adam B., primary, Admon, Andrew J., additional, Brenner, Samantha K., additional, Gupta, Shruti, additional, Lazarous, Deepa, additional, Leaf, David E., additional, Gershengorn, Hayley B., additional, Walther, Carl P., additional, Anumudu, Samaya J., additional, Arunthamakun, Justin, additional, Kopecky, Kathleen F., additional, Milligan, Gregory P., additional, McCullough, Peter A., additional, Nguyen, Thuy-Duyen, additional, Shaefi, Shahzad, additional, O’Gara, Brian P., additional, Krajewski, Megan L., additional, Baskin, Sean M., additional, Shankar, Sidharth, additional, Valencia, Juan D., additional, Pannu, Ameeka, additional, Hayes, Margaret M., additional, Grandin, E. Wilson, additional, Waikar, Sushrut S., additional, Kibbelaar, Zoe A., additional, Athavale, Ambarish M., additional, Hart, Peter, additional, Upadhyay, Shristi, additional, Vohra, Ishaan, additional, Oyintayo, Ajiboye, additional, Green, Adam, additional, Rachoin, Jean-Sebastien, additional, Schorr, Christa A., additional, Shea, Lisa, additional, Edmonston, Daniel L., additional, Mosher, Christopher L., additional, Shehata, Alexandre M., additional, Cohen, Zaza, additional, Allusson, Valerie, additional, Bambrick-Santoyo, Gabriela, additional, ul aain Bhatti, Noor, additional, Mehta, Bijal, additional, Williams, Aquino, additional, Walters, Patricia, additional, Go, Ronaldo C., additional, Rose, Keith M., additional, Hernán;, Miguel A., additional, Lisk, Rebecca, additional, Chan, Lili, additional, Mathews, Kusum S., additional, Coca, Steven G., additional, Altman, Deena R., additional, Saha, Aparna, additional, Soh, Howard, additional, Wen, Huei Hsun, additional, Bose, Sonali, additional, Leven, Emily A., additional, Wang, Jing G., additional, Mosoyan, Gohar, additional, Nadkarni, Girish N., additional, Pattharanitima, Pattharawin, additional, Gallagher, Emily J., additional, Friedman, Allon N., additional, Guirguis, John, additional, Kapoor, Rajat, additional, Meshberger, Christopher, additional, Kelly, Katherine J., additional, Parikh, Chirag R., additional, Garibaldi, Brian T., additional, Corona-Villalobos, Celia P., additional, Wen, Yumeng, additional, Menez, Steven, additional, Malik, Rubab F., additional, Elena Cervantes, Carmen, additional, Gautam, Samir C., additional, Mallappallil, Mary C., additional, Ouyang, Jie, additional, John, Sabu, additional, Yap, Ernie, additional, Melaku, Yohannes, additional, Mohamed, Ibrahim, additional, Bajracharya, Siddhartha, additional, Puri, Isha, additional, Thaxton, Mariah, additional, Bhattacharya, Jyotsna, additional, Wagner, John, additional, Boudourakis, Leon, additional, Nguyen, H. Bryant, additional, Ahoubim, Afshin, additional, Thomas, Leslie F., additional, Sirganagari, Dheeraj Reddy, additional, Guru, Pramod K., additional, Kashani, Kianoush, additional, Tehranian, Shahrzad, additional, Zhou, Yan, additional, Bergl, Paul A., additional, Rodriguez, Jesus, additional, Shah, Jatan A., additional, Gupta, Mrigank S., additional, Kumar, Princy N., additional, Lazarous, Deepa G., additional, Kassaye, Seble G., additional, Melamed, Michal L., additional, Johns, Tanya S., additional, Mocerino, Ryan, additional, Prudhvi, Kalyan, additional, Zhu, Denzel, additional, Levy, Rebecca V., additional, Azzi, Yorg, additional, Fisher, Molly, additional, Yunes, Milagros, additional, Sedaliu, Kaltrina, additional, Golestaneh, Ladan, additional, Brogan, Maureen, additional, Kumar, Neelja, additional, Chang, Michael, additional, Thakkar, Jyotsana, additional, Raichoudhury, Ritesh, additional, Athreya, Akshay, additional, Farag, Mohamed, additional, Schenck, Edward J., additional, Jung Cho, Soo, additional, Plataki, Maria, additional, Alvarez-Mulett, Sergio L., additional, Gomez-Escobar, Luis G., additional, Pan, Di, additional, Lee, Stefi, additional, Krishnan, Jamuna, additional, Whalen, William, additional, Charytan, David, additional, Macina, Ashley, additional, Chaudhry, Sobaata, additional, Wu, Benjamin, additional, Modersitzki, Frank, additional, Srivastava, Anand, additional, Leidner, Alexander S., additional, Martinez, Carlos, additional, Kruser, Jacqueline M., additional, Wunderink, Richard G., additional, Hodakowski, Alexander J., additional, Velez, Juan Carlos Q., additional, Price-Haywood, Eboni G., additional, Matute-Trochez, Luis A., additional, Hasty, Anna E., additional, Mohamed, Muner MB., additional, Avasare, Rupali S., additional, Zonies, David, additional, Sise, Meghan E., additional, Newman, Erik T., additional, Abu Omar, Samah, additional, Pokharel, Kapil K., additional, Sharma, Shreyak, additional, Singh, Harkarandeep, additional, Correa, Simon, additional, Shaukat, Tanveer, additional, Kamal, Omer, additional, Wang, Wei, additional, Yang, Heather, additional, Boateng, Jeffery O., additional, Lee, Meghan, additional, Strohbehn, Ian A., additional, Li, Jiahua, additional, Mueller, Ariel L., additional, Redfern, Roberta E., additional, Cairl, Nicholas S., additional, Naimy, Gabriel, additional, Abu-Saif, Abeer, additional, Hall, Danyell, additional, Bickley, Laura, additional, Rowan, Chris, additional, Madhani-Lovely, Farah, additional, Peev, Vasil, additional, Reiser, Jochen, additional, Byun, John J., additional, Vissing, Andrew, additional, Kapania, Esha M., additional, Post, Zoe, additional, Patel, Nilam P., additional, Hermes, Joy-Marie, additional, Sutherland, Anne K., additional, Patrawalla, Amee, additional, Finkel, Diana G., additional, Danek, Barbara A., additional, Arikapudi, Sowminya, additional, Paer, Jeffrey M., additional, Cangialosi, Peter, additional, Liotta, Mark, additional, Radbel, Jared, additional, Puri, Sonika, additional, Sunderram, Jag, additional, Scharf, Matthew T., additional, Ahmed, Ayesha, additional, Berim, Ilya, additional, Vatson, Jayanth S., additional, Anand, Shuchi, additional, Levitt, Joseph E., additional, Garcia, Pablo, additional, Boyle, Suzanne M., additional, Song, Rui, additional, Arif, Ali, additional, Zhang, Jingjing, additional, Woo, Sang Hoon, additional, Deng, Xiaoying, additional, Katz-Greenberg, Goni, additional, Senter, Katharine, additional, Sharshir, Moh’d A., additional, Rusnak, Vadym V., additional, Imran Ali, Muhammad, additional, Peters, Terri, additional, Hughes, Kathy, additional, Bansal, Anip, additional, Podoll, Amber S., additional, Chonchol, Michel, additional, Sharma, Sunita, additional, Burnham, Ellen L., additional, Rashidi, Arash, additional, Hejal, Rana, additional, Judd, Eric, additional, Latta, Laura, additional, Tolwani, Ashita, additional, Albertson, Timothy E., additional, Adams, Jason Y., additional, Chang, Steven Y., additional, Beutler, Rebecca M., additional, Schulze, Carl E., additional, Macedo, Etienne, additional, Rhee, Harin, additional, Liu, Kathleen D., additional, Jotwani, Vasantha K., additional, Koyner, Jay L., additional, Kunczt, Alissa, additional, Shah, Chintan V., additional, Jaikaransingh, Vishal, additional, Toth-Manikowski, Stephanie M., additional, Joo, Min J., additional, Lash, James P., additional, Neyra, Javier A., additional, Chaaban, Nourhan, additional, Elias, Madona, additional, Ahmad, Yahya, additional, Dy, Rajany, additional, Iardino, Alfredo, additional, Au, Elizabeth H., additional, Sharma, Jill H., additional, Anne Sosa, Marie, additional, Taldone, Sabrina, additional, Contreras, Gabriel, additional, De La Zerda, David, additional, Fornoni, Alessia, additional, Hayek, Salim S., additional, Blakely, Pennelope, additional, Berlin, Hanna, additional, Azam, Tariq U., additional, Shadid, Husam, additional, Pan, Michael, additional, O” Hayer, Patrick, additional, Meloche, Chelsea, additional, Feroze, Rafey, additional, Padalia, Kishan J., additional, Bitar, Abbas, additional, Leya, Jeff, additional, Donnelly, John P., additional, Flythe, Jennifer E., additional, Tugman, Matthew J., additional, Chang, Emily H., additional, Brown, Brent R., additional, Leonberg-Yoo, Amanda K., additional, Spiardi, Ryan C., additional, Miano, Todd A., additional, Roche, Meaghan S., additional, Vasquez, Charles R., additional, Bansal, Amar D., additional, Ernecoff, Natalie C., additional, Kapoor, Sanjana, additional, Verma, Siddharth, additional, Chen, Huiwen, additional, Kovesdy, Csaba P., additional, Molnar, Miklos Z., additional, Azhar, Ambreen, additional, Susan Hedayati, S., additional, Nadamuni, Mridula V., additional, Shastri, Shani, additional, Willett, Duwayne L., additional, Short, Samuel A.P., additional, Renaghan, Amanda D., additional, Enfield, Kyle B., additional, Bhatraju, Pavan K., additional, Bilal Malik, A., additional, Semler, Matthew W., additional, Vijayan, Anitha, additional, Mariyam Joy, Christina, additional, Li, Tingting, additional, Goldberg, Seth, additional, Kao, Patricia F., additional, Schumaker, Greg L., additional, Goyal, Nitender, additional, Faugno, Anthony J., additional, Hsu, Caroline M., additional, Tariq, Asma, additional, Meyer, Leah, additional, Kshirsagar, Ravi K., additional, Jose, Aju, additional, Weiner, Daniel E., additional, Christov, Marta, additional, Chugh, Savneek, additional, Griffiths, Jennifer, additional, Gupta, Sanjeev, additional, Kapoor, Aromma, additional, Wilson, Perry, additional, Arora, Tanima, additional, and Ugwuowo, Ugochukwu, additional

Published
2021
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213. Molecular and clinical signatures in Acute Kidney Injury define distinct subphenotypes that associate with death, kidney, and cardiovascular events

Author

Vasquez-Rios, George, primary, Oh, Wonsuk, additional, Lee, Samuel, additional, Bhatraju, Pavan, additional, Mansour, Sherry G., additional, Moledina, Dennis G., additional, Thiessen-Philbrook, Heather, additional, Siew, Eddie, additional, Garg, Amit X., additional, Chinchilli, Vernon M., additional, Kaufman, James S., additional, Hsu, Chi-yuan, additional, Liu, Kathleen D., additional, Kimmel, Paul L., additional, Go, Alan S., additional, Wurfel, Mark M., additional, Himmelfarb, Jonathan, additional, Parikh, Chirag R., additional, Coca, Steven G., additional, and Nadkarni, Girish N., additional

Published
2021
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214. Pre-Operative Kidney Biomarkers and Risks for Death, Cardiovascular and Chronic Kidney Disease Events: The TRIBE-AKI Study

Author

Vasquez-Rios, George, primary, Moledina, Dennis G., additional, Jia, Yaqi, additional, McArthur, Eric, additional, Mansour, Sherry G., additional, Thiessen-Philbrook, Heather, additional, Shlipak, Michael G., additional, Koyner, Jay L., additional, Garg, Amit X., additional, Parikh, Chirag R., additional, and Coca, Steve G., additional

Published
2021
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215. The incidence of and risk factors for hospitalized acute kidney injury among people living with HIV on antiretroviral treatment

Author

Muiru, Anthony N., primary, Madden, Erin, additional, Chilingirian, Ani, additional, Rubinsky, Anna D., additional, Scherzer, Rebecca, additional, Moore, Richard, additional, Villalobos, Celia P. Corona, additional, Monroy Trujillo, Jose Manuel, additional, Parikh, Chirag R., additional, Hsu, Chi‐yuan, additional, Shlipak, Michael G., additional, and Estrella, Michelle M., additional

Published
2021
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216. Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data

Author

Moledina, Dennis G, primary, Eadon, Michael T, additional, Calderon, Frida, additional, Yamamoto, Yu, additional, Shaw, Melissa, additional, Perazella, Mark A, additional, Simonov, Michael, additional, Luciano, Randy, additional, Schwantes-An, Tae-Hwi, additional, Moeckel, Gilbert, additional, Kashgarian, Michael, additional, Kuperman, Michael, additional, Obeid, Wassim, additional, Cantley, Lloyd G, additional, Parikh, Chirag R, additional, and Wilson, F Perry, additional

Published
2021
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217. Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events after Hospitalization: Findings from ASSESS-AKI and ARID studies

Author

Coca, Steven G., primary, Vasquez-Rios, George, additional, Mansour, Sherry G., additional, Moledina, Dennis G., additional, Thiessen-Philbrook, Heather, additional, Wurfel, Mark M., additional, Himmelfarb, Jonathan, additional, Siew, Eddie, additional, Garg, Amit X., additional, Hsu, Chi-yuan, additional, Liu, Kathleen D., additional, Kimmel, Paul L., additional, Chinchilli, Vernon M., additional, Kaufman, James S., additional, Wilson, Michelle, additional, Banks, Rosamonde E, additional, Packington, Rebecca, additional, McCole, Eibhlin, additional, Kurth, Mary Jo, additional, Richardson, Ciaran, additional, Go, Alan S., additional, Selby, Nicholas M, additional, and Parikh, Chirag R., additional

Published
2021
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218. Metabolites Associated with Coffee Consumption and Incident Chronic Kidney Disease

Author

He, William J., primary, Chen, Jingsha, additional, Razavi, Alexander C., additional, Hu, Emily A., additional, Grams, Morgan E., additional, Yu, Bing, additional, Parikh, Chirag R., additional, Boerwinkle, Eric, additional, Bazzano, Lydia, additional, Qi, Lu, additional, Kelly, Tanika N., additional, Coresh, Josef, additional, and Rebholz, Casey M., additional

Published
2021
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222. The Society of Thoracic Surgeons/Society of Cardiovascular Anesthesiologists/American Society for Extracorporeal Technology Clinical Practice Guidelines for the Prevention of Adult Cardiac Surgery–Associated Acute Kidney Injury.

Author

Brown, Jeremiah R., Baker, Robert A., Shore-Lesserson, Linda, Fox, Amanda A., Mongero, Linda B., Lobdell, Kevin W., LeMaire, Scott A., De Somer, Filip M. J. J., Wyler von Ballmoos, Moritz, Barodka, Viachaslau, Arora, Rakesh C., Firestone, Scott, Solomon, Richard, Parikh, Chirag R., Shann, Kenneth G., and Hammon, John

Published
2023
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223. The Society of Thoracic Surgeons/Society of Cardiovascular Anesthesiologists/American Society of Extracorporeal Technology Clinical Practice Guidelines for the Prevention of Adult Cardiac Surgery-Associated Acute Kidney Injury.

Author

Brown, Jeremiah R., Shore-Lesserson, Linda, Fox, Amanda A., Mongero, Linda B., Lobdell, Kevin W., LeMaire, Scott A., De Somer, Filip M. J. J., von Ballmoos, Moritz Wyler, Barodka, Viachaslau, Arora, Rakesh C., Firestone, Scott, Solomon, Richard, Parikh, Chirag R., Shann, Kenneth G., Hammon, John, and Baker, Robert A.

Subjects
ACUTE kidney failure prevention, COMPLICATIONS of cardiac surgery, MINIMALLY invasive procedures, DOPAMINE, MANNITOL
Abstract

The article provides guidelines for the prevention of adult cardiac surgery-associated acute kidney injury (CSA-AKI). It discusses various strategies to prevent and mitigate AKI after adult cardiac surgery, including goal-directed oxygen delivery, adopting the Kidney Disease Improving Global Outcomes (KDIGO), minimally invasive extracorporeal circulation (MiECC) techniques, and avoiding the use of dopamine infusion and mannitol. It further provides information on the rates of CSA-AKI.

Published
2022
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224. Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes.

Author

Chen, Teresa K., Coca, Steven G., Thiessen-Philbrook, Heather R., Heerspink, Hiddo J.L., Obeid, Wassim, Ix, Joachim H., Fried, Linda F., Bonventre, Joseph V., El-Khoury, Joe M., Shlipak, Michael G., and Parikh, Chirag R.

Subjects
KIDNEY physiology, CHRONIC kidney failure, DIABETIC nephropathies, GLOMERULAR filtration rate, BIOMARKERS
Abstract

Introduction: Diabetes is a leading cause of end-stage kidney disease (ESKD). Biomarkers of tubular health may prognosticate chronic kidney disease (CKD) progression beyond estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR). Methods: We examined associations of five urinary biomarkers of tubular injury and repair (NGAL, KIM-1, IL-18, MCP-1, YKL-40) with kidney function decline (first occurrence of a decrease in eGFR ≥30 mL/min/1.73 m2 if randomization eGFR ≥60 or ≥50% if randomization eGFR <60; ESKD) and all-cause mortality among 1,135 VA NEPHRON-D trial participants with baseline UACR ≥300 mg/g and available urine samples. Covariates included age, sex, race, BMI, systolic BP, HbA1c, treatment arm, eGFR, and UACR. In a subset of participants with 12-month samples (n = 712), we evaluated associations of KIM-1, MCP-1, and YKL-40 change (from baseline to 12 months) with eGFR decline (from 12 months onward). Results: At baseline, mean age was 65 years, mean eGFR was 56 mL/min/1.73 m2, and median UACR was 840 mg/g. Over a median of 2.2 years, 13% experienced kidney function decline and 9% died. In fully adjusted models, the highest versus lowest quartiles of MCP-1 and YKL-40 were associated with 2.18- and 1.76-fold higher risks of kidney function decline, respectively. One-year changes in KIM-1, MCP-1, and YKL-40 were not associated with subsequent eGFR decline. Higher baseline levels of NGAL, IL-18, MCP-1, and YKL-40 levels (per 2-fold higher) were independently associated with 10–40% higher risk of mortality. Conclusion: Among Veterans with diabetes and CKD, urinary biomarkers of tubular health were associated with kidney function decline and mortality. [ABSTRACT FROM AUTHOR]

Published
2022
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225. Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data.

Author

Moledina, Dennis G, Eadon, Michael T, Calderon, Frida, Yamamoto, Yu, Shaw, Melissa, Perazella, Mark A, Simonov, Michael, Luciano, Randy, Schwantes-An, Tae-Hwi, Moeckel, Gilbert, Kashgarian, Michael, Kuperman, Michael, Obeid, Wassim, Cantley, Lloyd G, Parikh, Chirag R, and Wilson, F Perry

Subjects
INTERSTITIAL nephritis, ELECTRONIC health records, RECEIVER operating characteristic curves, DATA recorders & recording, SPECIFIC gravity, RENAL biopsy
Abstract

Background Patients with acute interstitial nephritis (AIN) can present without typical clinical features, leading to a delay in diagnosis and treatment. We therefore developed and validated a diagnostic model to identify patients at risk of AIN using variables from the electronic health record. Methods In patients who underwent a kidney biopsy at Yale University between 2013 and 2018, we tested the association of >150 variables with AIN, including demographics, comorbidities, vital signs and laboratory tests (training set 70%). We used least absolute shrinkage and selection operator methodology to select prebiopsy features associated with AIN. We performed area under the receiver operating characteristics curve (AUC) analysis with internal (held-out test set 30%) and external validation (Biopsy Biobank Cohort of Indiana). We tested the change in model performance after the addition of urine biomarkers in the Yale AIN study. Results We included 393 patients (AIN 22%) in the training set, 158 patients (AIN 27%) in the test set, 1118 patients (AIN 11%) in the validation set and 265 patients (AIN 11%) in the Yale AIN study. Variables in the selected model included serum creatinine {adjusted odds ratio [aOR] 2.31 [95% confidence interval (CI) 1.42–3.76]}, blood urea nitrogen:creatinine ratio [aOR 0.40 (95% CI 0.20–0.78)] and urine dipstick specific gravity [aOR 0.95 (95% CI 0.91–0.99)] and protein [aOR 0.39 (95% CI 0.23–0.68)]. This model showed an AUC of 0.73 (95% CI 0.64–0.81) in the test set, which was similar to the AUC in the external validation cohort [0.74 (95% CI 0.69–0.79)]. The AUC improved to 0.84 (95% CI 0.76–0.91) upon the addition of urine interleukin-9 and tumor necrosis factor-α. Conclusions We developed and validated a statistical model that showed a modest AUC for AIN diagnosis, which improved upon the addition of urine biomarkers. Future studies could evaluate this model and biomarkers to identify unrecognized cases of AIN. [ABSTRACT FROM AUTHOR]

Published
2022
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227. Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States

Author

Walther, Carl P., Anumudu, Samaya J., Arunthamakun, Justin, Kopecky, Kathleen F., Milligan, Gregory P., McCullough, Peter A., Nguyen, Thuy-Duyen, Shaefi, Shahzad, Krajewski, Megan L., Shankar, Sidharth, Pannu, Ameeka, Valencia, Juan D., Waikar, Sushrut S., Kibbelaar, Zoe A., Athavale, Ambarish M., Hart, Peter, Upadhyay, Shristi, Vohra, Ishaan, Oyintayo, Ajiboye, Green, Adam, Rachoin, Jean-Sebastien, Schorr, Christa A., Shea, Lisa, Edmonston, Daniel L., Mosher, Christopher L., Shehata, Alexandre M., Cohen, Zaza, Allusson, Valerie, Bambrick-Santoyo, Gabriela, ul aain Bhatti, Noor, Mehta, Bijal, Williams, Aquino, Brenner, Samantha K., Walters, Patricia, Go, Ronaldo C., Rose, Keith M., Hernán, Miguel A., Zhou, Amy M., Kim, Ethan C., Lisk, Rebecca, Chan, Lili, Mathews, Kusum S., Coca, Steven G., Altman, Deena R., Saha, Aparna, Soh, Howard, Wen, Huei Hsun, Bose, Sonali, Leven, Emily A., Wang, Jing G., Mosoyan, Gohar, Nadkarni, Girish N., Pattharanitima, Pattharawin, Friedman, Allon N., Guirguis, John, Kapoor, Rajat, Meshberger, Christopher, Kelly, Katherine J., Parikh, Chirag R., Garibaldi, Brian T., Corona-Villalobos, Celia P., Wen, Yumeng, Menez, Steven, Malik, Rubab F., Cervantes, Elena, Gautam, Samir, Mallappallil, Mary C., Ouyang, Jie, John, Sabu, Yap, Ernie, Melaku, Yohannes, Mohamed, Ibrahim, Bajracharya, Siddartha, Puri, Isha, Thaxton, Mariah, Bhattacharya, Jyotsna, Wagner, John, Boudourakis, Leon, Nguyen, H. Bryant, Ahoubim, Afshin, Thomas, Leslie F., Sirganagari, Dheeraj Reddy, Guru, Pramod K., Kashani, Kianoush, Zhou, Yan, Bergl, Paul A., Rodriguez, Jesus, Shah, Jatan A., Gupta, Mrigank S., Kumar, Princy N., Lazarous, Deepa G., Kassaye, Seble G., Melamed, Michal L., Johns, Tanya S., Mocerino, Ryan, Prudhvi, Kalyan, Zhu, Denzel, Levy, Rebecca V., Azzi, Yorg, Fisher, Molly, Yunes, Milagros, Sedaliu, Kaltrina, Golestaneh, Ladan, Brogan, Maureen, Kumar, Neelja, Chang, Michael, Raichoudhury, Ritesh, Athreya, Akshay, Farag, Mohamed, Schenck, Edward J., Cho, Soo Jung, Plataki, Maria, Alvarez-Mulett, Sergio L., Gomez-Escobar, Luis G., Pan, Di, Lee, Stefi, Krishnan, Jamuna, Whalen, William, Charytan, David, Macina, Ashley, Chaudhry, Sobaata, Wu, Benjamin, Modersitzki, Frank, Srivastava, Anand, Leidner, Alexander S., Martinez, Carlos, Kruser, Jacqueline M., Wunderink, Richard G., Hodakowski, Alexander J., Velez, Juan Carlos Q., Price-Haywood, Eboni G., Matute-Trochez, Luis A., Hasty, Anna E., Mohamed, Muner MB., Avasare, Rupali S., Zonies, David, Leaf, David E., Gupta, Shruti, Sise, Meghan E., Newman, Erik T., Abu Omar, Samah, Pokharel, Kapil K., Sharma, Shreyak, Singh, Harkarandeep, Correa, Simon, Shaukat, Tanveer, Kamal, Omer, Wang, Wei, Yang, Heather, Boateng, Jeffery O., Lee, Meghan, Strohbehn, Ian A., Li, Jiahua, Mueller, Ariel L., Redfern, Roberta, Cairl, Nicholas S., Naimy, Gabriel, Abu-Saif, Abeer, Hall, Danyell, Bickley, Laura, Rowan, Chris, Madhani-Lovely, Farah, Cruz, Vivian S., Hess, Kristen M., Jacobs, Alanna L., Peev, Vasil, Reiser, Jochen, Byun, John J., Vissing, Andrew, Kapania, Esha M., Post, Zoe, Patel, Nilam P., Hermes, Joy-Marie, Sutherland, Anne K., Patrawalla, Amee, Finkel, Diana G., Danek, Barbara A., Arikapudi, Sowminya, Paer, Jeffrey M., Cangialosi, Peter, Liotta, Mark, Radbel, Jared, Puri, Sonika, Sunderram, Jag, Scharf, Matthew T., Ahmed, Ayesha, Berim, Ilya, Vatson, Jayanth S., Anand, Shuchi, Levitt, Joseph E., Boyle, Suzanne M., Song, Rui, Zhang, Jingjing, Woo, Sang Hoon, Deng, Xiaoying, Katz-Greenberg, Goni, Senter, Katharine, Sharshir, Moh’d A., Rusnak, Vadym V., Ali, Muhammad Imran, Bansal, Anip, Podoll, Amber S., Chonchol, Michel, Sharma, Sunita, Burnham, Ellen L., Rashidi, Arash, Hejal, Rana, Judd, Eric, Latta, Laura, Tolwani, Ashita, Albertson, Timothy E., Adams, Jason Y., Chang, Steven Y., Beutler, Rebecca M., Macedo, Etienne, Rhee, Harin, Liu, Kathleen D., Jotwani, Vasantha K., Koyner, Jay L., Shah, Chintan V., Jaikaransingh, Vishal, Toth-Manikowski, Stephanie M., Joo, Min J., Lash, James P., Neyra, Javier A., Chaaban, Nourhan, Elias, Madona, Ahmad, Yahya, Iardino, Alfredo, Au, Elizabeth H., Sharma, Jill H., Sosa, Marie Anne, Taldone, Sabrina, Contreras, Gabriel, De La Zerda, David, Gershengorn, Hayley B., Shukla, Bhavarth, Fornoni, Alessia, Ferreira, Tanira, Hayek, Salim S., Blakely, Pennelope, Berlin, Hanna, Azam, Tariq U., Shadid, Husam, Pan, Michael, O’ Hayer, Patrick, Meloche, Chelsea, Feroze, Rafey, Kaakati, Rayan, Perry, Danny, Bitar, Abbas, Anderson, Elizabeth, Padalia, Kishan J., Donnelly, John P., Admon, Andrew J., Flythe, Jennifer E., Tugman, Matthew J., Chang, Emily H., Brown, Brent R., Leonberg-Yoo, Amanda K., Spiardi, Ryan C., Miano, Todd A., Roche, Meaghan S., Vasquez, Charles R., Bansal, Amar D., Ernecoff, Natalie C., Kapoor, Sanjana, Verma, Siddharth, Kovesdy, Csaba P., Molnar, Miklos Z., Azhar, Ambreen, Hedayati, S. Susan, Nadamuni, Mridula V., Shastri, Shani, Willett, Duwayne L., Short, Samuel A.P., Renaghan, Amanda D., Enfield, Kyle B., Bhatraju, Pavan K., Malik, A. Bilal, Semler, Matthew W., Vijayan, Anitha, Joy, Christina Mariyam, Li, Tingting, Goldberg, Seth, Kao, Patricia F., Schumaker, Greg L., Goyal, Nitender, Faugno, Anthony J., Hsu, Caroline M., Tariq, Asma, Meyer, Leah, Kshirsagar, Ravi K., Weiner, Daniel E., Jose, Aju, Christov, Marta, Griffiths, Jennifer, Gupta, Sanjeev, Kapoor, Aromma, Wilson, Perry, Arora, Tanima, Ugwuowo, Ugochukwu, Jezmir, Julia L., Bharadwaj, Maheetha, Chaitoff, Alexander, Diephuis, Bradford, Crowley, Conor P., Kishore, Sandeep P., Goralnick, Eric, Merriam, Louis T., Milliken, Aimee, Rhee, Chanu, Sadovnikoff, Nicholas, Shah, Sejal B., Feldman, William B., and Kim, Edy Y.

Published
2021
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231. Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States

Author

Jezmir, Julia L., primary, Bharadwaj, Maheetha, additional, Chaitoff, Alexander, additional, Diephuis, Bradford, additional, Crowley, Conor P., additional, Kishore, Sandeep P., additional, Goralnick, Eric, additional, Merriam, Louis T., additional, Milliken, Aimee, additional, Rhee, Chanu, additional, Sadovnikoff, Nicholas, additional, Shah, Sejal B., additional, Gupta, Shruti, additional, Leaf, David E., additional, Feldman, William B., additional, Kim, Edy Y., additional, Walther, Carl P., additional, Anumudu, Samaya J., additional, Arunthamakun, Justin, additional, Kopecky, Kathleen F., additional, Milligan, Gregory P., additional, McCullough, Peter A., additional, Nguyen, Thuy-Duyen, additional, Shaefi, Shahzad, additional, Krajewski, Megan L., additional, Shankar, Sidharth, additional, Pannu, Ameeka, additional, Valencia, Juan D., additional, Waikar, Sushrut S., additional, Kibbelaar, Zoe A., additional, Athavale, Ambarish M., additional, Hart, Peter, additional, Upadhyay, Shristi, additional, Vohra, Ishaan, additional, Oyintayo, Ajiboye, additional, Green, Adam, additional, Rachoin, Jean-Sebastien, additional, Schorr, Christa A., additional, Shea, Lisa, additional, Edmonston, Daniel L., additional, Mosher, Christopher L., additional, Shehata, Alexandre M., additional, Cohen, Zaza, additional, Allusson, Valerie, additional, Bambrick-Santoyo, Gabriela, additional, ul aain Bhatti, Noor, additional, Mehta, Bijal, additional, Williams, Aquino, additional, Brenner, Samantha K., additional, Walters, Patricia, additional, Go, Ronaldo C., additional, Rose, Keith M., additional, Hernán, Miguel A., additional, Zhou, Amy M., additional, Kim, Ethan C., additional, Lisk, Rebecca, additional, Chan, Lili, additional, Mathews, Kusum S., additional, Coca, Steven G., additional, Altman, Deena R., additional, Saha, Aparna, additional, Soh, Howard, additional, Wen, Huei Hsun, additional, Bose, Sonali, additional, Leven, Emily A., additional, Wang, Jing G., additional, Mosoyan, Gohar, additional, Nadkarni, Girish N., additional, Pattharanitima, Pattharawin, additional, Friedman, Allon N., additional, Guirguis, John, additional, Kapoor, Rajat, additional, Meshberger, Christopher, additional, Kelly, Katherine J., additional, Parikh, Chirag R., additional, Garibaldi, Brian T., additional, Corona-Villalobos, Celia P., additional, Wen, Yumeng, additional, Menez, Steven, additional, Malik, Rubab F., additional, Cervantes, Elena, additional, Gautam, Samir, additional, Mallappallil, Mary C., additional, Ouyang, Jie, additional, John, Sabu, additional, Yap, Ernie, additional, Melaku, Yohannes, additional, Mohamed, Ibrahim, additional, Bajracharya, Siddartha, additional, Puri, Isha, additional, Thaxton, Mariah, additional, Bhattacharya, Jyotsna, additional, Wagner, John, additional, Boudourakis, Leon, additional, Nguyen, H. Bryant, additional, Ahoubim, Afshin, additional, Thomas, Leslie F., additional, Sirganagari, Dheeraj Reddy, additional, Guru, Pramod K., additional, Kashani, Kianoush, additional, Zhou, Yan, additional, Bergl, Paul A., additional, Rodriguez, Jesus, additional, Shah, Jatan A., additional, Gupta, Mrigank S., additional, Kumar, Princy N., additional, Lazarous, Deepa G., additional, Kassaye, Seble G., additional, Melamed, Michal L., additional, Johns, Tanya S., additional, Mocerino, Ryan, additional, Prudhvi, Kalyan, additional, Zhu, Denzel, additional, Levy, Rebecca V., additional, Azzi, Yorg, additional, Fisher, Molly, additional, Yunes, Milagros, additional, Sedaliu, Kaltrina, additional, Golestaneh, Ladan, additional, Brogan, Maureen, additional, Kumar, Neelja, additional, Chang, Michael, additional, Raichoudhury, Ritesh, additional, Athreya, Akshay, additional, Farag, Mohamed, additional, Schenck, Edward J., additional, Cho, Soo Jung, additional, Plataki, Maria, additional, Alvarez-Mulett, Sergio L., additional, Gomez-Escobar, Luis G., additional, Pan, Di, additional, Lee, Stefi, additional, Krishnan, Jamuna, additional, Whalen, William, additional, Charytan, David, additional, Macina, Ashley, additional, Chaudhry, Sobaata, additional, Wu, Benjamin, additional, Modersitzki, Frank, additional, Srivastava, Anand, additional, Leidner, Alexander S., additional, Martinez, Carlos, additional, Kruser, Jacqueline M., additional, Wunderink, Richard G., additional, Hodakowski, Alexander J., additional, Velez, Juan Carlos Q., additional, Price-Haywood, Eboni G., additional, Matute-Trochez, Luis A., additional, Hasty, Anna E., additional, Mohamed, Muner MB., additional, Avasare, Rupali S., additional, Zonies, David, additional, Sise, Meghan E., additional, Newman, Erik T., additional, Abu Omar, Samah, additional, Pokharel, Kapil K., additional, Sharma, Shreyak, additional, Singh, Harkarandeep, additional, Correa, Simon, additional, Shaukat, Tanveer, additional, Kamal, Omer, additional, Wang, Wei, additional, Yang, Heather, additional, Boateng, Jeffery O., additional, Lee, Meghan, additional, Strohbehn, Ian A., additional, Li, Jiahua, additional, Mueller, Ariel L., additional, Redfern, Roberta, additional, Cairl, Nicholas S., additional, Naimy, Gabriel, additional, Abu-Saif, Abeer, additional, Hall, Danyell, additional, Bickley, Laura, additional, Rowan, Chris, additional, Madhani-Lovely, Farah, additional, Cruz, Vivian S., additional, Hess, Kristen M., additional, Jacobs, Alanna L., additional, Peev, Vasil, additional, Reiser, Jochen, additional, Byun, John J., additional, Vissing, Andrew, additional, Kapania, Esha M., additional, Post, Zoe, additional, Patel, Nilam P., additional, Hermes, Joy-Marie, additional, Sutherland, Anne K., additional, Patrawalla, Amee, additional, Finkel, Diana G., additional, Danek, Barbara A., additional, Arikapudi, Sowminya, additional, Paer, Jeffrey M., additional, Cangialosi, Peter, additional, Liotta, Mark, additional, Radbel, Jared, additional, Puri, Sonika, additional, Sunderram, Jag, additional, Scharf, Matthew T., additional, Ahmed, Ayesha, additional, Berim, Ilya, additional, Vatson, Jayanth S., additional, Anand, Shuchi, additional, Levitt, Joseph E., additional, Boyle, Suzanne M., additional, Song, Rui, additional, Zhang, Jingjing, additional, Woo, Sang Hoon, additional, Deng, Xiaoying, additional, Katz-Greenberg, Goni, additional, Senter, Katharine, additional, Sharshir, Moh’d A., additional, Rusnak, Vadym V., additional, Ali, Muhammad Imran, additional, Bansal, Anip, additional, Podoll, Amber S., additional, Chonchol, Michel, additional, Sharma, Sunita, additional, Burnham, Ellen L., additional, Rashidi, Arash, additional, Hejal, Rana, additional, Judd, Eric, additional, Latta, Laura, additional, Tolwani, Ashita, additional, Albertson, Timothy E., additional, Adams, Jason Y., additional, Chang, Steven Y., additional, Beutler, Rebecca M., additional, Macedo, Etienne, additional, Rhee, Harin, additional, Liu, Kathleen D., additional, Jotwani, Vasantha K., additional, Koyner, Jay L., additional, Shah, Chintan V., additional, Jaikaransingh, Vishal, additional, Toth-Manikowski, Stephanie M., additional, Joo, Min J., additional, Lash, James P., additional, Neyra, Javier A., additional, Chaaban, Nourhan, additional, Elias, Madona, additional, Ahmad, Yahya, additional, Iardino, Alfredo, additional, Au, Elizabeth H., additional, Sharma, Jill H., additional, Sosa, Marie Anne, additional, Taldone, Sabrina, additional, Contreras, Gabriel, additional, De La Zerda, David, additional, Gershengorn, Hayley B., additional, Shukla, Bhavarth, additional, Fornoni, Alessia, additional, Ferreira, Tanira, additional, Hayek, Salim S., additional, Blakely, Pennelope, additional, Berlin, Hanna, additional, Azam, Tariq U., additional, Shadid, Husam, additional, Pan, Michael, additional, O’ Hayer, Patrick, additional, Meloche, Chelsea, additional, Feroze, Rafey, additional, Kaakati, Rayan, additional, Perry, Danny, additional, Bitar, Abbas, additional, Anderson, Elizabeth, additional, Padalia, Kishan J., additional, Donnelly, John P., additional, Admon, Andrew J., additional, Flythe, Jennifer E., additional, Tugman, Matthew J., additional, Chang, Emily H., additional, Brown, Brent R., additional, Leonberg-Yoo, Amanda K., additional, Spiardi, Ryan C., additional, Miano, Todd A., additional, Roche, Meaghan S., additional, Vasquez, Charles R., additional, Bansal, Amar D., additional, Ernecoff, Natalie C., additional, Kapoor, Sanjana, additional, Verma, Siddharth, additional, Kovesdy, Csaba P., additional, Molnar, Miklos Z., additional, Azhar, Ambreen, additional, Hedayati, S. Susan, additional, Nadamuni, Mridula V., additional, Shastri, Shani, additional, Willett, Duwayne L., additional, Short, Samuel A.P., additional, Renaghan, Amanda D., additional, Enfield, Kyle B., additional, Bhatraju, Pavan K., additional, Malik, A. Bilal, additional, Semler, Matthew W., additional, Vijayan, Anitha, additional, Joy, Christina Mariyam, additional, Li, Tingting, additional, Goldberg, Seth, additional, Kao, Patricia F., additional, Schumaker, Greg L., additional, Goyal, Nitender, additional, Faugno, Anthony J., additional, Hsu, Caroline M., additional, Tariq, Asma, additional, Meyer, Leah, additional, Kshirsagar, Ravi K., additional, Weiner, Daniel E., additional, Jose, Aju, additional, Christov, Marta, additional, Griffiths, Jennifer, additional, Gupta, Sanjeev, additional, Kapoor, Aromma, additional, Wilson, Perry, additional, Arora, Tanima, additional, and Ugwuowo, Ugochukwu, additional

Published
2021
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232. Identification of Distinct Clinical Subphenotypes in Critically Ill Patients With COVID-19

Author

Vasquez, Charles R., primary, Gupta, Shruti, additional, Miano, Todd A., additional, Roche, Meaghan, additional, Hsu, Jesse, additional, Yang, Wei, additional, Holena, Daniel N., additional, Reilly, John P., additional, Schrauben, Sarah J., additional, Leaf, David E., additional, Shashaty, Michael G.S., additional, Walther, Carl P., additional, Anumudu, Samaya J., additional, Arunthamakun, Justin, additional, Kopecky, Kathleen F., additional, Milligan, Gregory P., additional, McCullough, Peter A., additional, Nguyen, Thuy-Duyen, additional, Shaefi, Shahzad, additional, Krajewski, Megan L., additional, Shankar, Sidharth, additional, Pannu, Ameeka, additional, Valencia, Juan D., additional, Waikar, Sushrut S., additional, Kibbelaar, Zoe A., additional, Athavale, Ambarish M., additional, Hart, Peter, additional, Upadhyay, Shristi, additional, Vohra, Ishaan, additional, Oyintayo, Ajiboye, additional, Green, Adam, additional, Rachoin, Jean-Sebastien, additional, Schorr, Christa A., additional, Shea, Lisa, additional, Edmonston, Daniel L., additional, Mosher, Christopher L., additional, Shehata, Alexandre M., additional, Cohen, Zaza, additional, Allusson, Valerie, additional, Bambrick-Santoyo, Gabriela, additional, Bhatti, Noor ul aain, additional, Mehta, Bijal, additional, Williams, Aquino, additional, Brenner, Samantha K., additional, Walters, Patricia, additional, Go, Ronaldo C., additional, Rose, Keith M., additional, Chan, Lili, additional, Mathews, Kusum S., additional, Coca, Steven G., additional, Altman, Deena R., additional, Saha, Aparna, additional, Soh, Howard, additional, Wen, Huei Hsun, additional, Bose, Sonali, additional, Leven, Emily A., additional, Wang, Jing G., additional, Mosoyan, Gohar, additional, Nadkarni, Girish N., additional, Pattharanitima, Pattharawin, additional, Gallagher, Emily J., additional, Friedman, Allon N., additional, Guirguis, John, additional, Kapoor, Rajat, additional, Meshberger, Christopher, additional, Kelly, Katherine J., additional, Parikh, Chirag R., additional, Garibaldi, Brian T., additional, Corona-Villalobos, Celia P., additional, Wen, Yumeng, additional, Menez, Steven, additional, Malik, Rubab F., additional, Cervantes, Carmen Elena, additional, Gautam, Samir C., additional, Mallappallil, Mary C., additional, Ouyang, Jie, additional, John, Sabu, additional, Yap, Ernie, additional, Melaku, Yohannes, additional, Mohamed, Ibrahim, additional, Bajracharya, Siddhartha, additional, Puri, Isha, additional, Thaxton, Mariah, additional, Bhattacharya, Jyotsna, additional, Wagner, John, additional, Boudourakis, Leon, additional, Nguyen, H. Bryant, additional, Ahoubim, Afshin, additional, Kashani, Kianoush, additional, Tehranian, Shahrzad, additional, Thomas, Leslie F., additional, Sirganagari, Dheeraj Reddy, additional, Guru, Pramod K., additional, Zhou, Yan, additional, Bergl, Paul A., additional, Rodriguez, Jesus, additional, Shah, Jatan A., additional, Gupta, Mrigank S., additional, Kumar, Princy N., additional, Lazarous, Deepa G., additional, Kassaye, Seble G., additional, Melamed, Michal L., additional, Johns, Tanya S., additional, Mocerino, Ryan, additional, Prudhvi, Kalyan, additional, Zhu, Denzel, additional, Levy, Rebecca V., additional, Azzi, Yorg, additional, Fisher, Molly, additional, Yunes, Milagros, additional, Sedaliu, Kaltrina, additional, Golestaneh, Ladan, additional, Brogan, Maureen, additional, Kumar, Neelja, additional, Chang, Michael, additional, Thakkar, Jyotsana, additional, Raichoudhury, Ritesh, additional, Athreya, Akshay, additional, Farag, Mohamed, additional, Schenck, Edward J., additional, Cho, Soo Jung, additional, Plataki, Maria, additional, Alvarez-Mulett, Sergio L., additional, Gomez-Escobar, Luis G., additional, Pan, Di, additional, Lee, Stefi, additional, Krishnan, Jamuna, additional, Whalen, William, additional, Charytan, David, additional, Macina, Ashley, additional, Chaudhry, Sobaata, additional, Wu, Benjamin, additional, Modersitzki, Frank, additional, Srivastava, Anand, additional, Leidner, Alexander S., additional, Martinez, Carlos, additional, Kruser, Jacqueline M., additional, Wunderink, Richard G., additional, Hodakowski, Alexander J., additional, Velez, Juan Carlos Q., additional, Price-Haywood, Eboni G., additional, Matute-Trochez, Luis A., additional, Hasty, Anna E., additional, Mohamed, Muner M.B., additional, Avasare, Rupali S., additional, Zonies, David, additional, Sise, Meghan E., additional, Newman, Erik T., additional, Omar, Samah Abu, additional, Pokharel, Kapil K., additional, Sharma, Shreyak, additional, Singh, Harkarandeep, additional, Correa, Simon, additional, Shaukat, Tanveer, additional, Kamal, Omer, additional, Wang, Wei, additional, Yang, Heather, additional, Boateng, Jeffery O., additional, Lee, Meghan, additional, Strohbehn, Ian A., additional, Li, Jiahua, additional, Mueller, Ariel L., additional, Redfern, Roberta E., additional, Cairl, Nicholas S., additional, Naimy, Gabriel, additional, Abu-Saif, Abeer, additional, Hall, Danyell, additional, Bickley, Laura, additional, Rowan, Chris, additional, Madhani-Lovely, Farah, additional, Peev, Vasil, additional, Reiser, Jochen, additional, Byun, John J., additional, Vissing, Andrew, additional, Kapania, Esha M., additional, Post, Zoe, additional, Patel, Nilam P., additional, Hermes, Joy-Marie, additional, Sutherland, Anne K., additional, Patrawalla, Amee, additional, Finkel, Diana G., additional, Danek, Barbara A., additional, Arikapudi, Sowminya, additional, Paer, Jeffrey M., additional, Cangialosi, Peter, additional, Liotta, Mark, additional, Radbel, Jared, additional, Puri, Sonika, additional, Sunderram, Jag, additional, Scharf, Matthew T., additional, Ahmed, Ayesha, additional, Berim, Ilya, additional, Vatson, Jayanth S., additional, Anand, Shuchi, additional, Levitt, Joseph E., additional, Garcia, Pablo, additional, Boyle, Suzanne M., additional, Song, Rui, additional, Zhang, Jingjing, additional, Woo, Sang Hoon, additional, Deng, Xiaoying, additional, Katz-Greenberg, Goni, additional, Senter, Katharine, additional, Sharshir, Moh’d A., additional, Rusnak, Vadym V., additional, Ali, Muhammad Imran, additional, Bansal, Anip, additional, Podoll, Amber S., additional, Chonchol, Michel, additional, Sharma, Sunita, additional, Burnham, Ellen L., additional, Rashidi, Arash, additional, Hejal, Rana, additional, Judd, Eric, additional, Latta, Laura, additional, Tolwani, Ashita, additional, Albertson, Timothy E., additional, Adams, Jason Y., additional, Chang, Steven Y., additional, Beutler, Rebecca M., additional, Schulze, Carl E., additional, Macedo, Etienne, additional, Rhee, Harin, additional, Liu, Kathleen D., additional, Jotwani, Vasantha K., additional, Koyner, Jay L., additional, Kunczt, Alissa, additional, Shah, Chintan V., additional, Jaikaransingh, Vishal, additional, Toth-Manikowski, Stephanie M., additional, Joo, Min J., additional, Lash, James P., additional, Neyra, Javier A., additional, Chaaban, Nourhan, additional, Ahmad, Yahya, additional, Elias, Madona, additional, Dy, Rajany, additional, Iardino, Alfredo, additional, Au, Elizabeth H., additional, Sharma, Jill H., additional, Sosa, Marie Anne, additional, Taldone, Sabrina, additional, Contreras, Gabriel, additional, De La Zerda, David, additional, Gershengorn, Hayley B., additional, Hayek, Salim S., additional, Blakely, Pennelope, additional, Berlin, Hanna, additional, Azam, Tariq U., additional, Shadid, Husam, additional, Pan, Michael, additional, Hayer, Patrick O’, additional, Meloche, Chelsea, additional, Feroze, Rafey, additional, Kaakati, Rayan, additional, Perry, Danny, additional, Bitar, Abbas, additional, Anderson, Elizabeth, additional, Padalia, Kishan J., additional, Donnelly, John P., additional, Admon, Andrew J., additional, Flythe, Jennifer E., additional, Tugman, Matthew J., additional, Chang, Emily H., additional, Brown, Brent R., additional, Leonberg-Yoo, Amanda K., additional, Spiardi, Ryan C., additional, Roche, Meaghan S., additional, Vasquez, Charles R., additional, Bansal, Amar D., additional, Ernecoff, Natalie C., additional, Kapoor, Sanjana, additional, Verma, Siddharth, additional, Chen, Huiwen, additional, Kovesdy, Csaba P., additional, Molnar, Miklos Z., additional, Azhar, Ambreen, additional, Hedayati, S. Susan, additional, Nadamuni, Mridula V., additional, Shastri, Shani, additional, Willett, Duwayne L., additional, Short, Samuel A.P., additional, Renaghan, Amanda D., additional, Enfield, Kyle B., additional, Bhatraju, Pavan K., additional, Malik, A. Bilal, additional, Semler, Matthew W., additional, Vijayan, Anitha, additional, Joy, Christina Mariyam, additional, Li, Tingting, additional, Goldberg, Seth, additional, Kao, Patricia F., additional, Schumaker, Greg L., additional, Goyal, Nitender, additional, Faugno, Anthony J., additional, Hsu, Caroline M., additional, Tariq, Asma, additional, Meyer, Leah, additional, Kshirsagar, Ravi K., additional, Weiner, Daniel E., additional, Jose, Aju, additional, Christov, Marta, additional, Griffiths, Jennifer, additional, Gupta, Sanjeev, additional, Kapoor, Aromma, additional, Chugh, Savneek, additional, Wilson, Perry, additional, Arora, Tanima, additional, and Ugwuowo, Ugochukwu, additional

Published
2021
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233. Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis

Author

Schmidt, Insa M., primary, Colona, Mia R., additional, Kestenbaum, Bryan R., additional, Alexopoulos, Leonidas G., additional, Palsson, Ragnar, additional, Srivastava, Anand, additional, Liu, Jing, additional, Stillman, Isaac E., additional, Rennke, Helmut G., additional, Vaidya, Vishal S., additional, Wu, Haojia, additional, Humphreys, Benjamin D., additional, Waikar, Sushrut S., additional, Knight, Richard, additional, Lecker, Stewart H., additional, Stillman, Isaac, additional, Bogen, Steve, additional, Amodu, Afolarin A., additional, Ilori, Titlayo, additional, Maikhor, Shana, additional, Schmidt, Insa M., additional, Beck, Laurence H., additional, Henderson, Joel M., additional, Onul, Ingrid, additional, Verma, Ashish, additional, McMahon, Gearoid M., additional, Valerius, M. Todd, additional, Waikar, Sushrut, additional, Weins, Astrid, additional, Greka, Anna, additional, Hacohen, Nir, additional, Hoover, Paul J., additional, Marshall, Jamie L., additional, Aulisio, Mark, additional, Chen, Yijiang M., additional, Janowczyk, Andrew, additional, Jayapandian, Catherine, additional, Viswanathan, Vidya S., additional, Bush, William S., additional, Crawford, Dana C., additional, Madabhushi, Anant, additional, Bush, Lakeshia, additional, Cooperman, Leslie, additional, Gonzalez-Vicente, Agustin, additional, Herlitz, Leal, additional, Jolly, Stacey, additional, Nguyen, Jane, additional, O’toole, John, additional, Palmer, Ellen, additional, Poggio, Emilio, additional, Sedor, John, additional, Sendrey, Dianna, additional, Spates-Harden, Kassandra, additional, Taliercio, Jonathan, additional, Bjornstad, Petter M., additional, Pyle, Laura, additional, Vinovskis, Carissa, additional, Appelbaum, Paul, additional, Balderes, Olivia, additional, Barasch, Jonathan M., additional, Bomback, Andrew S., additional, Canetta, Pietro A., additional, D’Agati, Vivette D., additional, Kiryluk, Krzysztof, additional, Kudose, Satoru, additional, Mehl, Karla, additional, Shang, Ning, additional, Bansal, Shweta, additional, Alexandrov, Theodore, additional, Rennke, Helmut, additional, El-Achkar, Tarek M., additional, Barwinska, Daria, additional, Bledso, Sharon, additional, Borner, Katy, additional, Bueckle, Andreas, additional, Cheng, Yinghua, additional, Dagher, Pierre C., additional, Dunn, Kenneth W., additional, Eadon, Michael T., additional, Ferkowicz, Michael J., additional, Herr, Bruce W., additional, Kelly, Katherine J., additional, Ferreira, Ricardo Melo, additional, Quardokus, Ellen M., additional, Record, Elizabeth, additional, Rivera, Marcelino, additional, Su, Jing, additional, Sutton, Timothy A., additional, Williams, James C., additional, Winfree, Seth, additional, Jain, Yashvardhan, additional, Menez, Steven, additional, Parikh, Chirag R., additional, Rosenberg, Avi, additional, Corona-Villalobos, Celia P., additional, Wen, Yumeng, additional, Johansen, Camille, additional, Rosas, Sylvia E., additional, Roy, Neil, additional, Sun, Jennifer, additional, Williams, Mark, additional, Azeloglu, Evren U., additional, Hansen, Jens, additional, He, Cijang, additional, Iyengar, Ravi, additional, Xiong, Yuguang, additional, Prasad, Pottumarthi, additional, Madhavan, Sethu M., additional, Parikh, Samir, additional, Rovin, Brad, additional, Shapiro, John P., additional, Anderton, Christopher R., additional, Lukowski, Jessica, additional, Pasa-Tolic, Ljiljana, additional, Velickovic, Dusan, additional, Oliver, George (Holt), additional, Ardayfio, Joseph, additional, Bebiak, Jack, additional, Brown, Keith, additional, Campbell, Taneisha, additional, Campbell, Catherine E., additional, Hayashi, Lynda, additional, Jefferson, Nichole, additional, Roberts, Glenda V., additional, Saul, John, additional, Shpigel, Anna, additional, Stutzke, Christy, additional, Koewler, Robert, additional, Pinkeney, Roy, additional, Sealfon, Rachel, additional, Troyanskaya, Olga, additional, Wong, Aaron, additional, Tuttle, Katherine R., additional, Pollack, Ari, additional, Goltsev, Yury, additional, Ginley, Brandon, additional, Lucarelli, Nicholas, additional, Lutnick, Brendon, additional, Sarder, Pinaki, additional, Lake, Blue B., additional, Zhang, Kun, additional, Boada, Patrick, additional, Laszik, Zoltan G., additional, Nolan, Garry, additional, Anjani, Kavya, additional, Sarwal, Minnie, additional, Mukatash, Tariq, additional, Sigdel, Tara, additional, Alloway, Rita R., additional, Burg, Ashley R., additional, Lee, Paul J., additional, Rike, Adele, additional, Shi, Tiffany, additional, Woodle, E. Steve, additional, Ascani, Heather, additional, Balis, Ulysses G.J., additional, Blanc, Victoria M., additional, Conser, Ninive C., additional, Eddy, Sean, additional, Frey, Renee, additional, He, Yougqun, additional, Hodgin, Jeffrey B., additional, Kretzler, Matthias, additional, Lienczewski, Chrysta, additional, Luo, Jinghui, additional, Mariani, Laura H., additional, Menon, Rajasree, additional, Otto, Edgar, additional, Schaub, Jennifer, additional, Steck, Becky, additional, Elder, Michele M., additional, Gilliam, Matthew, additional, Hall, Daniel E., additional, Murugan, Raghavan, additional, Palevsky, Paul M., additional, Randhawa, Parmjeet, additional, Rosengart, Matthew, additional, Tublin, Mitchell, additional, Vita, Tina, additional, Winters, James, additional, Kellum, John A., additional, Alpers, Charles E., additional, Berglund, Ashley, additional, Berry, Brooke, additional, Blank, Kristina N., additional, Carson, Jonas, additional, Daniel, Stephen, additional, De Boer, Ian H., additional, Dighe, Ashveena L., additional, Dowd, Frederick, additional, Grewenow, Stephanie M., additional, Himmelfarb, Jonathan, additional, Hoofnagle, Andrew N., additional, Limonte, Christine, additional, McClelland, Robyn L., additional, Mooney, Sean D., additional, Rezaei, Kasra, additional, Shankland, Stuart, additional, Snyder, Jamie, additional, Wang, Ruikang, additional, Wilcox, Adam, additional, Williams, Kayleen, additional, Park, Christopher, additional, Montellano, Richard, additional, Pamreddy, Annapurna, additional, Sharma, Kumar, additional, Venkatachalam, Manjeri, additional, Ye, Hongping, additional, Zhang, Guanshi, additional, Basit, Mujeeb, additional, Hedayati, S. Susan, additional, Kermani, Asra, additional, Lee, Simon C., additional, Lu, Christopher Y., additional, Miller, R. Tyler, additional, Moe, Orson W., additional, Patel, Jiten, additional, Pillai, Anil, additional, Sambandam, Kamalanathan, additional, Torrealba, Jose, additional, Toto, Robert D., additional, Vazquez, Miguel, additional, Wang, Nancy, additional, Wen, Natasha, additional, Zhang, Dianbo, additional, Park, Harold, additional, Caprioli, Richard M., additional, Patterson, Nathan, additional, Sharman, Kavya, additional, Spraggins, Jeffrey M., additional, Van de Plas, Raf, additional, Basta, Jeanine, additional, Diettman, Sabine M., additional, Gaut, Joseph P., additional, Jain, Sanjay, additional, Rauchman, Michael I., additional, Vijayan, Anitha, additional, Cantley, Lloyd G., additional, Kakade, Vijaykumar R., additional, Moledina, Dennis, additional, Shaw, Melissa M., additional, Ugwuowo, Ugochukwu, additional, Wilson, Francis P., additional, and Arora, Tanima, additional

Published
2021
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235. Post-transplant Diabetes Mellitus in Kidney Transplant Recipients: A Multicenter Study

Author

Malik, Rubab F., primary, Jia, Yaqi, additional, Mansour, Sherry G., additional, Reese, Peter P., additional, Hall, Isaac E., additional, Alasfar, Sami, additional, Doshi, Mona D., additional, Akalin, Enver, additional, Bromberg, Jonathan S., additional, Harhay, Meera N., additional, Mohan, Sumit, additional, Muthukumar, Thangamani, additional, Schröppel, Bernd, additional, Singh, Pooja, additional, Weng, Francis L., additional, Thiessen Philbrook, Heather R., additional, and Parikh, Chirag R., additional

Published
2021
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236. Hospital-Level Variation in Death for Critically Ill Patients with COVID-19

Author

Churpek, Matthew M., primary, Gupta, Shruti, additional, Spicer, Alexandra B., additional, Parker, William F., additional, Fahrenbach, John, additional, Brenner, Samantha K., additional, Leaf, David E., additional, Walther, Carl P., additional, Anumudu, Samaya J., additional, Arunthamakun, Justin, additional, Kopecky, Kathleen F., additional, Milligan, Gregory P., additional, McCullough, Peter A., additional, Nguyen, Thuy-Duyen, additional, Shaefi, Shahzad, additional, Krajewski, Megan L., additional, Shankar, Sidharth, additional, Pannu, Ameeka, additional, Valencia, Juan D., additional, Waikar, Sushrut S., additional, Kibbelaar, Zoe A., additional, Athavale, Ambarish M., additional, Hart, Peter, additional, Upadhyay, Shristi, additional, Vohra, Ishaan, additional, Green, Adam, additional, Rachoin, Jean-Sebastien, additional, Schorr, Christa A., additional, Shea, Lisa, additional, Edmonston, Daniel L., additional, Mosher, Christopher L., additional, Shehata, Alexandre M., additional, Cohen, Zaza, additional, Allusson, Valerie, additional, Bambrick-Santoyo, Gabriela, additional, ul aain Bhatti, Noor, additional, Mehta, Bijal, additional, Williams, Aquino, additional, Walters, Patricia, additional, Go, Ronaldo C., additional, Rose, Keith M., additional, Hernán, Miguel A., additional, Chan, Lili, additional, Mathews, Kusum S., additional, Coca, Steven G., additional, Altman, Deena R., additional, Saha, Aparna, additional, Soh, Howard, additional, Wen, Huei Hsun, additional, Bose, Sonali, additional, Leven, Emily A., additional, Wang, Jing G., additional, Mosoyan, Gohar, additional, Nadkarni, Girish N., additional, Pattharanitima, Pattharawin, additional, Gallagher, Emily J., additional, Friedman, Allon N., additional, Guirguis, John, additional, Kapoor, Rajat, additional, Meshberger, Christopher, additional, Kelly, Katherine J., additional, Parikh, Chirag R., additional, Garibaldi, Brian T., additional, Corona-Villalobos, Celia P., additional, Wen, Yumeng, additional, Menez, Steven, additional, Malik, Rubab F., additional, Cervantes, Elena, additional, Gautam, Samir, additional, Mallappallil, Mary C., additional, Ouyang, Jie, additional, John, Sabu, additional, Yap, Ernie, additional, Melaku, Yohannes, additional, Mohamed, Ibrahim, additional, Bajracharya, Siddartha, additional, Puri, Isha, additional, Thaxton, Mariah, additional, Bhattacharya, Jyotsna, additional, Wagner, John, additional, Boudourakis, Leon, additional, Nguyen, H. Bryant, additional, Ahoubim, Afshin, additional, Thomas, Leslie F., additional, Sirganagari, Dheeraj Reddy, additional, Guru, Pramod K., additional, Kashani, Kianoush, additional, Tehranian, Shahrzad, additional, Zhou, Yan, additional, Bergl, Paul A., additional, Rodriguez, Jesus, additional, Shah, Jatan A., additional, Gupta, Mrigank S., additional, Kumar, Princy N., additional, Lazarous, Deepa G., additional, Kassaye, Seble G., additional, Melamed, Michal L., additional, Johns, Tanya S., additional, Mocerino, Ryan, additional, Prudhvi, Kalyan, additional, Zhu, Denzel, additional, Levy, Rebecca V., additional, Azzi, Yorg, additional, Fisher, Molly, additional, Yunes, Milagros, additional, Sedaliu, Kaltrina, additional, Golestaneh, Ladan, additional, Brogan, Maureen, additional, Kumar, Neelja, additional, Chang, Michael, additional, Thakkar, Jyotsana, additional, Raichoudhury, Ritesh, additional, Athreya, Akshay, additional, Farag, Mohamed, additional, Schenck, Edward J., additional, Cho, Soo Jung, additional, Plataki, Maria, additional, Alvarez-Mulett, Sergio L., additional, Gomez-Escobar, Luis G., additional, Pan, Di, additional, Lee, Stefi, additional, Krishnan, Jamuna, additional, Whalen, William, additional, Charytan, David, additional, Macina, Ashley, additional, Chaudhry, Sobaata, additional, Wu, Benjamin, additional, Modersitzki, Frank, additional, Srivastava, Anand, additional, Leidner, Alexander S., additional, Martinez, Carlos, additional, Kruser, Jacqueline M., additional, Wunderink, Richard G., additional, Hodakowski, Alexander J., additional, Velez, Juan Carlos Q., additional, Price-Haywood, Eboni G., additional, Matute-Trochez, Luis A., additional, Hasty, Anna E., additional, Mohamed, Muner M. B., additional, Avasare, Rupali S., additional, Zonies, David, additional, Sise, Meghan E., additional, Newman, Erik T., additional, Abu Omar, Samah, additional, Pokharel, Kapil K., additional, Sharma, Shreyak, additional, Singh, Harkarandeep, additional, Correa, Simon, additional, Shaukat, Tanveer, additional, Kamal, Omer, additional, Wang, Wei, additional, Yang, Heather, additional, Boateng, Jeffery O., additional, Lee, Meghan, additional, Strohbehn, Ian A., additional, Li, Jiahua, additional, Mueller, Ariel L., additional, Redfern, Roberta, additional, Cairl, Nicholas S., additional, Naimy, Gabriel, additional, Abu-Saif, Abeer, additional, Hall, Danyell, additional, Bickley, Laura, additional, Rowan, Chris, additional, Madhai-Lovely, Farah, additional, Peev, Vasil, additional, Reiser, Jochen, additional, Byun, John J., additional, Vissing, Andrew, additional, Kapania, Esha M., additional, Post, Zoe, additional, Patel, Nilam P., additional, Hermes, Joy-Marie, additional, Sutherland, Anne K., additional, Patrawalla, Amee, additional, Finkel, Diana G., additional, Danek, Barbara A., additional, Arikapudi, Sowminya, additional, Paer, Jeffrey M., additional, Cangialosi, Peter, additional, Liotta, Mark, additional, Radbel, Jared, additional, Sunderram, Jag, additional, Puri, Sonika, additional, Vatson, Jayanth S., additional, Scharf, Matthew T., additional, Ahmed, Ayesha, additional, Berim, Ilya, additional, Anand, Shuchi, additional, Levitt, Joseph E., additional, Garcia, Pablo, additional, Boyle, Suzanne M., additional, Song, Rui, additional, Arif, Ali, additional, Zhang, Jingjing, additional, Woo, Sang Hoon, additional, Deng, Xiaoying, additional, Katz-Greenberg, Goni, additional, Senter, Katharine, additional, Sharshir, Moh’d A., additional, Rusnak, Vadym V., additional, Ali, Muhammad Imran, additional, Peters, Terri, additional, Hughes, Kathy, additional, Bansal, Anip, additional, Podoll, Amber S., additional, Chonchol, Michel, additional, Sharma, Sunita, additional, Burnham, Ellen L., additional, Rashidi, Arash, additional, Hejal, Rana, additional, Judd, Eric, additional, Latta, Laura, additional, Tolwani, Ashita, additional, Albertson, Timothy E., additional, Adams, Jason Y., additional, Chang, Steven Y., additional, Beutler, Rebecca M., additional, Monica, Santa, additional, Schulze, Carl E., additional, Macedo, Etienne, additional, Rhee, Harin, additional, Liu, Kathleen D., additional, Jotwani, Vasantha K., additional, Koyner, Jay L., additional, Shah, Chintan V., additional, Jaikaransingh, Vishal, additional, Toth-Manikowski, Stephanie M., additional, Joo, Min J., additional, Lash, James P., additional, Neyra, Javier A., additional, Chaaban, Nourhan, additional, Iardino, Alfredo, additional, Au, Elizabeth H., additional, Sharma, Jill H., additional, Sosa, Marie Anne, additional, Taldone, Sabrina, additional, Contreras, Gabriel, additional, De La Zerda, David, additional, Fornoni, Alessia, additional, Gershengorn, Hayley B., additional, Hayek, Salim S., additional, Blakely, Pennelope, additional, Berlin, Hanna, additional, Azam, Tariq U., additional, Shadid, Husam, additional, Pan, Michael, additional, O’Hayer, Patrick, additional, Meloche, Chelsea, additional, Feroze, Rafey, additional, Kaakati, Rayan, additional, Perry, Danny, additional, Bitar, Abbas, additional, Anderson, Elizabeth, additional, Padalia, Kishan J., additional, Launius, Christopher, additional, Donnelly, John P., additional, Admon, Andrew J., additional, Flythe, Jennifer E., additional, Tugman, Matthew J., additional, Chang, Emily H., additional, Brown, Brent R., additional, Leonberg-Yoo, Amanda K., additional, Spiardi, Ryan C., additional, Miano, Todd A., additional, Roche, Meaghan S., additional, Vasquez, Charles R., additional, Bansal, Amar D., additional, Ernecoff, Natalie C., additional, Kapoor, Sanjana, additional, Verma, Siddharth, additional, Chen, Huiwen, additional, Kovesdy, Csaba P., additional, Molnar, Miklos Z., additional, Azhar, Ambreen, additional, Hedayati, S. Susan, additional, Nadamuni, Mridula V., additional, Shastri, Shani, additional, Willett, Duwayne L., additional, Short, Samuel A. P., additional, Renaghan, Amanda D., additional, Enfield, Kyle B., additional, Bhatraju, Pavan K., additional, Malik, A. Bilal, additional, Semler, Matthew W., additional, Vijayan, Anitha, additional, Joy, Christina Mariyam, additional, Li, Tingting, additional, Goldberg, Seth, additional, Kao, Patricia F., additional, Schumaker, Greg L., additional, Goyal, Nitender, additional, Faugno, Anthony J., additional, Hsu, Caroline M., additional, Tariq, Asma, additional, Meyer, Leah, additional, Kshirsagar, Ravi K., additional, Weiner, Daniel E., additional, Christov, Marta, additional, Griffiths, Jennifer, additional, Gupta, Sanjeev, additional, Kapoor, Aromma, additional, Wilson, Perry, additional, Arora, Tanima, additional, and Ugwuowo, Ugochukwu, additional

Published
2021
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238. Machine Learning Prediction of Death in Critically Ill Patients With Coronavirus Disease 2019

Author

Churpek, Matthew M., primary, Gupta, Shruti, additional, Spicer, Alexandra B., additional, Hayek, Salim S., additional, Srivastava, Anand, additional, Chan, Lili, additional, Melamed, Michal L., additional, Brenner, Samantha K., additional, Radbel, Jared, additional, Madhani-Lovely, Farah, additional, Bhatraju, Pavan K., additional, Bansal, Anip, additional, Green, Adam, additional, Goyal, Nitender, additional, Shaefi, Shahzad, additional, Parikh, Chirag R., additional, Semler, Matthew W., additional, and Leaf, David E., additional

Published
2021
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239. Characterization of Glomerular and Tubulointerstitial Proteomes in a Case of Nonsteroidal Anti-Inflammatory Drug–Attributed Acute Kidney Injury

Author

Parikh, Samir V., Madhavan, Sethu, Shapiro, John, Knight, Richard, Rosenberg, Avi Z., Parikh, Chirag R., Rovin, Brad, and Menez, Steven

Abstract

The major goals of the Kidney Precision Medicine Project (KPMPP) are to establish a molecular atlas of the kidney in health and disease and improve our understanding of the molecular drivers of CKD and AKI. In this clinical-pathologic-molecular correlation, we describe the case of a 38-year-old woman without any history of CKD who underwent a research kidney biopsy in the setting of AKI suspected to be due to nonsteroidal anti-inflammatory use after cesarean section delivery. The participant's histopathology was consistent with mild acute tubular injury, without significant interstitial fibrosis or tubular atrophy. This diagnosis was supported by analysis of the glomerular and tubulointerstitial proteomes. The proteomic interrogation revealed a molecular landscape that demonstrated differences in kidney prostaglandin synthesis that may be in response to nonsteroidal anti-inflammatory drugs and signs of intrarenal inflammation and fibrosis that were not evident by histopathology alone.

Published
2023
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240. Rationale and design of the Kidney Precision Medicine Project

Author

Knight, Richard, Lecker, Stewart, Stillman, Isaac, Waikar, Sushrut, Mcmahon, Gearoid, Weins, Astrid, Short, Samuel, Hacohen, Nir, Hoover, Paul, Aulisio, Mark, Cooperman, Leslie, Herlitz, Leal, O’Toole, John, Poggio, Emilio, Sedor, John, Jolly, Stacey, Appelbaum, Paul, Balderes, Olivia, Barasch, Jonathan, Bomback, Andrew, Canetta, Pietro A., d’Agati, Vivette D., Kiryluk, Krzysztof, Kudose, Satoru, Mehl, Karla, Radhakrishnan, Jai, Weng, Chenhua, Barisoni, Laura, Alexandrov, Theodore, Ashkar, Tarek, Barwinska, Daria, Dagher, Pierre, Dunn, Kenneth, Eadon, Michael, Ferkowicz, Michael, Kelly, Katherine, Sutton, Timothy, Winfree, Seth, Menez, Steven, Parikh, Chirag, Rosenberg, Avi, Villalobos, Pam, Malik, Rubab, Fine, Derek, Atta, Mohammed, Monroy Trujillo, Jose Manuel, Slack, Alison, Rosas, Sylvia, Williams, Mark, Azeloglu, Evren, He, Cijang (John), Iyengar, Ravi, Hansen, Jens, Parikh, Samir, Rovin, Brad, Anderton, Chris, Pasa-Tolic, Ljiljana, Velickovic, Dusan, Lukowski, Jessica, Oliver, George (Holt), Ardayfio, Joseph, Bebiak, Jack, Brown, Keith, Campbell, Taneisha, Campbell, Catherine, Hayashi, Lynda, Jefferson, Nichole, Koewler, Robert, Roberts, Glenda, Saul, John, Shpigel, Anna, Stutzke, Edith Christine, Wright, Lorenda, Miegs, Leslie, Pinkeney, Roy, Sealfon, Rachel, Troyanskaya, Olga, Tuttle, Katherine, Dobi, Dejan, Goltsev, Yury, Lake, Blue, Zhang, Kun, Joanes, Maria, Laszik, Zoltan, Schroeder, Andrew, Sarwal, Minnie, Sigdel, Tara, Balis, Ulysses, Blanc, Victoria, He, Oliver, Hodgin, Jeffrey, Kretzler, Matthias, Mariani, Laura, Menon, Rajasree, Otto, Edgar, Schaub, Jennifer, Steck, Becky, Lienczewski, Chrysta, Eddy, Sean, Elder, Michele, Hall, Daniel, Kellum, John, Kruth, Mary, Murugan, Raghav, Palevsky, Paul, Randhawa, Parmjeet, Rosengart, Matthew, Sims-Lucas, Sunny, Stefanick, Mary, Stull, Stacy, Tublin, Mitchell, Alpers, Charles, de Boer, Ian, Dighe, Ashveena, Himmelfarb, Jonathan, Mcclelland, Robyn, Mooney, Sean, Shankland, Stuart, Williams, Kayleen, Blank, Kristina, Carson, Jonas, Dowd, Frederick, Drager, Zach, Park, Christopher, Sharma, Kumar, Zhang, Guanshi, Bansal, Shweta, Venkatachalam, Manjeri, Kermani, Asra, Lee, Simon, Lu, Christopher, Miller, Tyler, Moe, Orson, Park, Harold, Sambandam, Kamalanathan, Sanchez, Francisco, Torrealba, Jose, Robert, Toto, Vazquez, Miguel, Wang, Nancy, Gaut, Joe, Jain, Sanjay, Vijayan, Anitha, Luciano, Randy, Moledina, Dennis, Ugochukwu, Ugwuowo, Wilson, Francis Perry, Alfano, Sandy, de Boer, Ian H., Alpers, Charles E., Azeloglu, Evren U., Balis, Ulysses G.J., Barasch, Jonathan M., Blank, Kristina N., Bomback, Andrew S., Dagher, Pierre C., Dighe, Ashveena L., Eadon, Michael T., El-Achkar, Tarek M., Gaut, Joseph P., He, Yongqun, Hodgin, Jeffrey B., Kellum, John A., Laszik, Zoltan G., Mariani, Laura H., McClelland, Robyn L., Moledina, Dennis G., Mooney, Sean D., O’Toole, John F., Palevsky, Paul M., Parikh, Chirag R., Poggio, Emilio D., Rosas, Sylvia E., Rosengart, Matthew R., Sarwal, Minnie M., Schaub, Jennifer A., Sedor, John R., Toto, Robert D., Troyanskaya, Olga G., Tuttle, Katherine R., Vazquez, Miguel A., and Waikar, Sushrut S.

Published
2021
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243. The Relationship Between Urine Uromodulin and Blood Pressure Changes: The DASH-Sodium Trial

Author

Bakhoum, Christine Y, Anderson, Cheryl AM, Juraschek, Stephen P, Rebholz, Casey M, Appel, Lawrence J, Miller, Edgar R, Parikh, Chirag R, Obeid, Wassim, Rifkin, Dena E, Ix, Joachim H, and Garimella, Pranav S

Subjects
Aging, hypertension, Dietary Approaches To Stop Hypertension, uromodulin, Clinical Trials and Supportive Activities, Clinical Sciences, Dietary, blood pressure, DASH, Sodium Chloride, Cardiovascular, Mice, Cardiovascular System & Hematology, Clinical Research, salt sensitivity, Animals, Humans, sodium, Nutrition
Abstract

BackgroundUromodulin modulates the sodium-potassium-two-chloride transporter in the thick ascending limb of the loop of Henle, and its overexpression in murine models leads to salt-induced hypertension. We hypothesized that individuals with higher baseline levels of urine uromodulin would have a greater increase in systolic blood pressure (SBP) for the same increase in sodium compared with those with lower uromodulin levels.MethodsWe used data from 157 subjects randomized to the control diet of the Dietary Approaches to Stop Hypertension (DASH)-Sodium trial who were assigned to 30 days of low (1,500 mg/d), medium (2,400 mg/d), and high salt (3,300 mg/d) diets in random order. Blood pressure was measured prerandomization and then weekly during each feeding period. We evaluated the association of prerandomization urine uromodulin with change in SBP between diets, as measured at the end of each feeding period, using multivariable linear regression.ResultsBaseline urine uromodulin stratified by tertiles was ≤17.64, 17.65-31.97, and ≥31.98 µg/ml. Across the tertiles, there were no significant differences in SBP at baseline, nor was there a differential effect of sodium diet on SBP across tertiles (low to high, P = 0.81). After adjusting for age, sex, body mass index, and race, uromodulin levels were not significantly associated with SBP change from low to high sodium diet (P = 0.42).ConclusionsIn a randomized trial of different levels of salt intake, higher urine uromodulin levels were not associated with a greater increase in blood pressure in response to high salt intake.

Published
2021

244. Rationale and design of the Kidney Precision Medicine Project

Author

de Boer, Ian H, Alpers, Charles E, Azeloglu, Evren U, Balis, Ulysses GJ, Barasch, Jonathan M, Barisoni, Laura, Blank, Kristina N, Bomback, Andrew S, Brown, Keith, Dagher, Pierre C, Dighe, Ashveena L, Eadon, Michael T, El-Achkar, Tarek M, Gaut, Joseph P, Hacohen, Nir, He, Yongqun, Hodgin, Jeffrey B, Jain, Sanjay, Kellum, John A, Kiryluk, Krzysztof, Knight, Richard, Laszik, Zoltan G, Lienczewski, Chrysta, Mariani, Laura H, McClelland, Robyn L, Menez, Steven, Moledina, Dennis G, Mooney, Sean D, O'Toole, John F, Palevsky, Paul M, Parikh, Chirag R, Poggio, Emilio D, Rosas, Sylvia E, Rosengart, Matthew R, Sarwal, Minnie M, Schaub, Jennifer A, Sedor, John R, Sharma, Kumar, Steck, Becky, Toto, Robert D, Troyanskaya, Olga G, Tuttle, Katherine R, Vazquez, Miguel A, Waikar, Sushrut S, Williams, Kayleen, Wilson, Francis Perry, Zhang, Kun, Iyengar, Ravi, Kretzler, Matthias, Himmelfarb, Jonathan, and Kidney Precision Medicine Project

Subjects
Proteomics, Adult, Transplantation, hypertension, Kidney Disease, diabetes, precision medicine, Prevention, Clinical Sciences, Renal and urogenital, Acute Kidney Injury, Urology & Nephrology, Kidney, Kidney Precision Medicine Project, Good Health and Well Being, acute kidney injury, Clinical Research, Humans, Prospective Studies, Renal Insufficiency, Chronic, Precision Medicine, chronic kidney disease
Abstract

Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment. The Kidney Precision Medicine Project aims to ethically and safely obtain kidney biopsies from participants with CKD or AKI, create a reference kidney atlas, and characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes. An additional aim is to identify critical cells, pathways, and targets for novel therapies and preventive strategies. This project is a multicenter prospective cohort study of adults with CKD or AKI who undergo a protocol kidney biopsy for research purposes. This investigation focuses on kidney diseases that are most prevalent and therefore substantially burden the public health, including CKD attributed to diabetes or hypertension and AKI attributed to ischemic and toxic injuries. Reference kidney tissues (for example, living-donor kidney biopsies) will also be evaluated. Traditional and digital pathology will be combined with transcriptomic, proteomic, and metabolomic analysis of the kidney tissue as well as deep clinical phenotyping for supervised and unsupervised subgroup analysis and systems biology analysis. Participants will be followed prospectively for 10 years to ascertain clinical outcomes. Cell types, locations, and functions will be characterized in health and disease in an open, searchable, online kidney tissue atlas. All data from the Kidney Precision Medicine Project will be made readily available for broad use by scientists, clinicians, and patients.

Published
2021

245. A prospective cohort study of acute kidney injury and kidney outcomes, cardiovascular events, and death

Author

Ikizler, T Alp, Parikh, Chirag R, Himmelfarb, Jonathan, Chinchilli, Vernon M, Liu, Kathleen D, Coca, Steven G, Garg, Amit X, Hsu, Chi-Yuan, Siew, Edward D, Wurfel, Mark M, Ware, Lorraine B, Faulkner, Georgia Brown, Tan, Thida C, Kaufman, James S, Kimmel, Paul L, Go, Alan S, and ASSESS-AKI Study Investigators

Subjects
Adult, Aging, Kidney Disease, Clinical Sciences, Renal and urogenital, Aftercare, heart failure, urologic and male genital diseases, Kidney, Cardiovascular, acute renal failure, Risk Factors, cardiovascular disease, Clinical Research, Humans, Prospective Studies, urogenital system, Acute Kidney Injury, Urology & Nephrology, mortality, female genital diseases and pregnancy complications, Patient Discharge, ASSESS-AKI Study Investigators, Good Health and Well Being, Cardiovascular Diseases, chronic kidney disease, Glomerular Filtration Rate
Abstract

Acute kidney injury (AKI) has been reported to be associated with excess risks of death, kidney disease progression and cardiovascular events although previous studies have important limitations. To further examine this, we prospectively studied adults from four clinical centers surviving three months and more after hospitalization with or without AKI who were matched on center, pre-admission CKD status, and an integrated priority score based on age, prior cardiovascular disease or diabetes mellitus, preadmission estimated glomerular filtration rate (eGFR) and treatment in the intensive care unit during the index hospitalization between December 2009-February 2015, with follow-up through November 2018. All participants had assessments of kidney function before (eGFR) and at three months and annually (eGFR and proteinuria) after the index hospitalization. Associations of AKI with outcomes were examined after accounting for pre-admission and three-month post-discharge factors. Among 769 AKI (73% Stage 1, 14% Stage 2, 13% Stage 3) and 769 matched non-AKI adults, AKI was associated with higher adjusted rates of incident CKD (adjusted hazard ratio 3.98, 95% confidence interval 2.51-6.31), CKD progression (2.37,1.28-4.39), heart failure events (1.68, 1.22-2.31) and all-cause death (1.78, 1.24-2.56). AKI was not associated with major atherosclerotic cardiovascular events in multivariable analysis (0.95, 0.70-1.28). After accounting for degree of kidney function recovery and proteinuria at three months after discharge, the associations of AKI with heart failure (1.13, 0.80-1.61) and death (1.29, 0.84-1.98) were attenuated and no longer significant. Thus, assessing kidney function recovery and proteinuria status three months after AKI provides important prognostic information for long-term clinical outcomes.

Published
2021

246. Absence of long-term changes in urine biomarkers after AKI: findings from the CRIC study.

Author

McCoy, Ian E., Hsu, Jesse Y., Bonventre, Joseph V., Parikh, Chirag R., Go, Alan S., Liu, Kathleen D., Ricardo, Ana C., Srivastava, Anand, Cohen, Debbie L., He, Jiang, Chen, Jing, Rao, Panduranga S., Muiru, Anthony N., and Hsu, Chi-yuan

Abstract

Background: Mechanisms by which AKI leads to CKD progression remain unclear. Several urine biomarkers have been identified as independent predictors of progressive CKD. It is unknown whether AKI may result in long-term changes in these urine biomarkers, which may mediate the effect of AKI on CKD progression.Methods: We selected 198 episodes of hospitalized AKI (defined as peak/nadir inpatient serum creatinine values ≥ 1.5) among adult participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. We matched the best non-AKI hospitalization (unique patients) for each AKI hospitalization using pre-hospitalization characteristics including eGFR and urine protein/creatinine ratio. Biomarkers were measured in banked urine samples collected at annual CRIC study visits.Results: Urine biomarker measurements occurred a median of 7 months before and 5 months after hospitalization. There were no significant differences in the change in urine biomarker-to-creatinine ratio between the AKI and non-AKI groups: KIM-1/Cr + 9% vs + 7%, MCP-1/Cr + 4% vs + 1%, YKL-40/Cr + 7% vs -20%, EGF/Cr -11% vs -8%, UMOD/Cr -2% vs -7% and albumin/Cr + 17% vs + 13% (all p > 0.05).Conclusion: In this cohort of adults with CKD, AKI did not associate with long-term changes in urine biomarkers. [ABSTRACT FROM AUTHOR]

Published
2022
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247. Perioperative Aspirin and Clonidine and Risk of Acute Kidney Injury: A Randomized Clinical Trial

Author

Garg, Amit X., Kurz, Andrea, Sessler, Daniel I., Cuerden, Meaghan, Robinson, Andrea, Mrkobrada, Marko, Parikh, Chirag R., Mizera, Richard, Jones, Philip M., Tiboni, Maria, Font, Adrià, Cegarra, Virginia, Rojas Gomez, Maria Fernanda, Meyhoff, Christian S., VanHelder, Tomas, Chan, Matthew T.V., Torres, David, Parlow, Joel, de Nadal, Miriam Clanchet, Amir, Mohammed, Bidgoli, Seyed Javad, Pasin, Laura, Martinsen, Kristian, Malaga, German, Myles, Paul, Acedillo, Rey, Roshanov, Pavel S., Walsh, Michael, Dresser, George, Kumar, Priya, Fleischmann, Edith, Villar, Juan Carlos, Painter, Thomas, Biccard, Bruce, Bergese, Sergio, Srinathan, Sadeesh, Cata, Juan P., Chan, Vincent, Mehra, Bhupendra, Wijeysundera, Duminda N., Leslie, Kate, Forget, Patrice, Whitlock, Richard, Yusuf, Salim, and Devereaux, P. J.

Published
2014
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