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201. APOL1 Genotype and Glomerular and Tubular Kidney Injury in Women With HIV

Author

Jotwani, Vasantha, primary, Shlipak, Michael G., additional, Scherzer, Rebecca, additional, Parekh, Rulan S., additional, Kao, W.H. Linda, additional, Bennett, Michael, additional, Cohen, Mardge H., additional, Nowicki, Marek, additional, Sharma, Anjali, additional, Young, Mary, additional, Tien, Phyllis C., additional, Parikh, Chirag R., additional, and Estrella, Michelle M., additional

Published
2015
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202. Free Levels of Selected Organic Solutes and Cardiovascular Morbidity and Mortality in Hemodialysis Patients: Results from the Retained Organic Solutes and Clinical Outcomes (ROSCO) Investigators

Author

Shafi, Tariq, primary, Meyer, Timothy W., additional, Hostetter, Thomas H., additional, Melamed, Michal L., additional, Parekh, Rulan S., additional, Hwang, Seungyoung, additional, Banerjee, Tanushree, additional, Coresh, Josef, additional, and Powe, Neil R., additional

Published
2015
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206. Re-Sequencing of the APOL1-APOL4 and MYH9 Gene Regions in African Americans Does Not Identify Additional Risks for CKD Progression

Author

Hawkins, Gregory A., primary, Friedman, David J., additional, Lu, Lingyi, additional, McWilliams, David R., additional, Chou, Jeff W., additional, Sajuthi, Satria, additional, Divers, Jasmin, additional, Parekh, Rulan S., additional, Li, Man, additional, Genovese, Giulio, additional, Pollack, Martin R., additional, Hicks, Pamela J., additional, Bowden, Donald W., additional, Ma, Lijun, additional, Freedman, Barry I., additional, and Langefeld, Carl D., additional

Published
2015
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209. The Expanding Role of APOL1 Risk in Chronic Kidney Disease and Cardiovascular Disease.

Author

Estrella, Michelle M. and Parekh, Rulan S.

Abstract

Variants of the APOL1 gene, found primarily in individuals of African descent, are associated with various forms of kidney disease and kidney disease progression. Recent studies evaluating the association of APOL1 with cardiovascular disease have yielded conflicting results, and the potential role in cardiovascular disease remains unclear. In this review, we summarize the observational studies linking the APOL1 risk variants with chronic kidney and cardiovascular disease among persons of African descent. [ABSTRACT FROM AUTHOR]

Published
2017
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211. Health-Related and Psychosocial Concerns about Transplantation among Patients Initiating Dialysis

Author

Salter, Megan L., primary, Gupta, Natasha, additional, King, Elizabeth, additional, Bandeen-Roche, Karen, additional, Law, Andrew H., additional, McAdams-DeMarco, Mara A., additional, Meoni, Lucy A., additional, Jaar, Bernard G., additional, Sozio, Stephen M., additional, Kao, Wen Hong Linda, additional, Parekh, Rulan S., additional, and Segev, Dorry L., additional

Published
2014
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212. Troponin I and NT-proBNP and the Association of Systolic Blood Pressure With Outcomes in Incident Hemodialysis Patients: The Choices for Healthy Outcomes in Caring for ESRD (CHOICE) Study

Author

Shafi, Tariq, primary, Zager, Philip G., additional, Sozio, Stephen M., additional, Grams, Morgan E., additional, Jaar, Bernard G., additional, Christenson, Robert H., additional, Boulware, L. Ebony, additional, Parekh, Rulan S., additional, Powe, Neil R., additional, and Coresh, Josef, additional

Published
2014
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214. Incidental findings on cardiac computed tomography in incident hemodialysis patients: the predictors of arrhythmic and cardiovascular events in end-stage renal disease (PACE) study

Author

Jaar, Bernard G, primary, Zhang, Lili, additional, Chembrovich, Svetlana V, additional, Sozio, Stephen M, additional, Shafi, Tariq, additional, Scialla, Julia J, additional, Tomaselli, Gordon F, additional, Lima, Joao A C, additional, Kao, Wen Hong Linda, additional, Parekh, Rulan S, additional, and Meoni, Lucy A, additional

Published
2014
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215. Biomarkers of Vascular Calcification and Mortality in Patients with ESRD

Author

Scialla, Julia J., primary, Kao, W.H. Linda, additional, Crainiceanu, Ciprian, additional, Sozio, Stephen M., additional, Oberai, Pooja C., additional, Shafi, Tariq, additional, Coresh, Josef, additional, Powe, Neil R., additional, Plantinga, Laura C., additional, Jaar, Bernard G., additional, and Parekh, Rulan S., additional

Published
2014
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216. A Genome-Wide Search for Linkage of Estimated Glomerular Filtration Rate (eGFR) in the Family Investigation of Nephropathy and Diabetes (FIND)

Author

Thameem, Farook, Thameem, Farook, Igo, Robert P, Freedman, Barry I, Langefeld, Carl, Hanson, Robert L, Schelling, Jeffrey R, Elston, Robert C, Duggirala, Ravindranath, Nicholas, Susanne B, Goddard, Katrina A. B, Divers, Jasmin, Guo, Xiuqing, Ipp, Eli, Kimmel, Paul L, Meoni, Lucy A, Shah, Vallabh O, Smith, Michael W, Winkler, Cheryl A, Zager, Philip G, Knowler, William C, Nelson, Robert G, Pahl, Madeline V, Parekh, Rulan S, Kao, W. H. Linda, Rasooly, Rebekah S, Adler, Sharon G, Abboud, Hanna E, Iyengar, Sudha K, Sedor, John R, Cai, Tao, Thameem, Farook, Thameem, Farook, Igo, Robert P, Freedman, Barry I, Langefeld, Carl, Hanson, Robert L, Schelling, Jeffrey R, Elston, Robert C, Duggirala, Ravindranath, Nicholas, Susanne B, Goddard, Katrina A. B, Divers, Jasmin, Guo, Xiuqing, Ipp, Eli, Kimmel, Paul L, Meoni, Lucy A, Shah, Vallabh O, Smith, Michael W, Winkler, Cheryl A, Zager, Philip G, Knowler, William C, Nelson, Robert G, Pahl, Madeline V, Parekh, Rulan S, Kao, W. H. Linda, Rasooly, Rebekah S, Adler, Sharon G, Abboud, Hanna E, Iyengar, Sudha K, Sedor, John R, and Cai, Tao

Published
2013

217. Antiretroviral-treated HIV-infected women have similar long-term kidney function trajectories as HIV-uninfected women.

Author

Estrella, Michelle M, Estrella, Michelle M, Abraham, Alison G, Jing, Yuezhou, Parekh, Rulan S, Tien, Phyllis C, Merenstein, Dan, Pearce, Celeste Leigh, Anastos, Kathryn, Cohen, Mardge H, Dehovitz, Jack A, Gange, Stephen J, Estrella, Michelle M, Estrella, Michelle M, Abraham, Alison G, Jing, Yuezhou, Parekh, Rulan S, Tien, Phyllis C, Merenstein, Dan, Pearce, Celeste Leigh, Anastos, Kathryn, Cohen, Mardge H, Dehovitz, Jack A, and Gange, Stephen J

Abstract

Natural history studies suggest increased risk for kidney function decline with HIV infection, but few studies have made comparisons with HIV-uninfected women. We examined whether HIV infection treated with highly active antiretroviral therapy (HAART) remains associated with faster kidney function decline in the Women's Interagency HIV Study. HIV-infected women initiating HAART with (n=105) or without (n=373) tenofovir (TDF) were matched to HIV-uninfected women on calendar and length of follow-up, age, systolic blood pressure, hepatitis C antibody serostatus, and diabetes history. Linear mixed models were used to evaluate differences in annual estimated glomerular filtration rate (eGFR). Person-visits were 4,741 and 11,512 for the TDF-treated and non-TDF-treated analyses, respectively. Mean baseline eGFRs were higher among women initiated on TDF-containing HAART and lower among those on TDF-sparing HAART compared to their respective HIV-uninfected matches (p<0.05 for both). HIV-infected women had annual rates of eGFR changes similar to HIV-uninfected matches (p-interaction >0.05 for both). Adjusting for baseline eGFR, mean eGFRs at 1 and 3 years of follow-up among women initiated on TDF-containing HAART were lower than their uninfected matches (-4.98 and -4.26 ml/min/1.73 m(2), respectively; p<0.05 for both). Mean eGFR of women initiated on TDF-sparing HAART was lower versus uninfected matches at 5 years (-2.19 ml/min/1.73 m(2), p=0.03). HAART-treated HIV-infected women had lower mean eGFRs at follow-up but experienced rates of annual eGFR decline similar to HIV-uninfected women. Tenofovir use in HIV-infected women with normal kidney function did not accelerate long-term kidney function decline relative to HIV-uninfected women.

Published
2013

218. APOL1 risk variants, race, and progression of chronic kidney disease.

Author

Parsa, Afshin, Parsa, Afshin, Kao, WH Linda, Xie, Dawei, Astor, Brad C, Li, Man, Hsu, Chi-yuan, Feldman, Harold I, Parekh, Rulan S, Kusek, John W, Greene, Tom H, Fink, Jeffrey C, Anderson, Amanda H, Choi, Michael J, Wright, Jackson T, Lash, James P, Freedman, Barry I, Ojo, Akinlolu, Winkler, Cheryl A, Raj, Dominic S, Kopp, Jeffrey B, He, Jiang, Jensvold, Nancy G, Tao, Kaixiang, Lipkowitz, Michael S, Appel, Lawrence J, AASK Study Investigators, CRIC Study Investigators, Parsa, Afshin, Parsa, Afshin, Kao, WH Linda, Xie, Dawei, Astor, Brad C, Li, Man, Hsu, Chi-yuan, Feldman, Harold I, Parekh, Rulan S, Kusek, John W, Greene, Tom H, Fink, Jeffrey C, Anderson, Amanda H, Choi, Michael J, Wright, Jackson T, Lash, James P, Freedman, Barry I, Ojo, Akinlolu, Winkler, Cheryl A, Raj, Dominic S, Kopp, Jeffrey B, He, Jiang, Jensvold, Nancy G, Tao, Kaixiang, Lipkowitz, Michael S, Appel, Lawrence J, AASK Study Investigators, and CRIC Study Investigators

Abstract

BackgroundAmong patients in the United States with chronic kidney disease, black patients are at increased risk for end-stage renal disease, as compared with white patients.MethodsIn two studies, we examined the effects of variants in the gene encoding apolipoprotein L1 (APOL1) on the progression of chronic kidney disease. In the African American Study of Kidney Disease and Hypertension (AASK), we evaluated 693 black patients with chronic kidney disease attributed to hypertension. In the Chronic Renal Insufficiency Cohort (CRIC) study, we evaluated 2955 white patients and black patients with chronic kidney disease (46% of whom had diabetes) according to whether they had 2 copies of high-risk APOL1 variants (APOL1 high-risk group) or 0 or 1 copy (APOL1 low-risk group). In the AASK study, the primary outcome was a composite of end-stage renal disease or a doubling of the serum creatinine level. In the CRIC study, the primary outcomes were the slope in the estimated glomerular filtration rate (eGFR) and the composite of end-stage renal disease or a reduction of 50% in the eGFR from baseline.ResultsIn the AASK study, the primary outcome occurred in 58.1% of the patients in the APOL1 high-risk group and in 36.6% of those in the APOL1 low-risk group (hazard ratio in the high-risk group, 1.88; P<0.001). There was no interaction between APOL1 status and trial interventions or the presence of baseline proteinuria. In the CRIC study, black patients in the APOL1 high-risk group had a more rapid decline in the eGFR and a higher risk of the composite renal outcome than did white patients, among those with diabetes and those without diabetes (P<0.001 for all comparisons).ConclusionsRenal risk variants in APOL1 were associated with the higher rates of end-stage renal disease and progression of chronic kidney disease that were observed in black patients as compared with white patients, regardless of diabetes status. (Funded by the National Institute of Diabetes and Digestive

Published
2013

219. Global Prevalence of Protein-Energy Wasting in Kidney Disease: A Meta-analysis of Contemporary Observational Studies From the International Society of Renal Nutrition and Metabolism

Author

Carrero, Juan J., Thomas, Fridtjof, Nagy, Kristóf, Arogundade, Fatiu, Avesani, Carla M., Chan, Maria, Chmielewski, Michal, Cordeiro, Antonio C., Espinosa-Cuevas, Angeles, Fiaccadori, Enrico, Guebre-Egziabher, Fitsum, Hand, Rosa K., Hung, Adriana M., Ikizler, Talat A., Johansson, Lina R., Kalantar-Zadeh, Kamyar, Karupaiah, Tilakavati, Lindholm, Bengt, Marckmann, Peter, Mafra, Denise, Parekh, Rulan S., Park, Jongha, Russo, Sharon, Saxena, Anita, Sezer, Siren, Teta, Daniel, Ter Wee, Pieter M., Verseput, Cecile, Wang, Angela Y.M., Xu, Hong, Lu, Yimin, Molnar, Miklos Z., and Kovesdy, Csaba P.

Abstract

To better define the prevalence of protein-energy wasting (PEW) in kidney disease is poorly defined.

Published
2018
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221. APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease

Author

Parsa, Afshin, primary, Kao, W.H. Linda, additional, Xie, Dawei, additional, Astor, Brad C., additional, Li, Man, additional, Hsu, Chi-yuan, additional, Feldman, Harold I., additional, Parekh, Rulan S., additional, Kusek, John W., additional, Greene, Tom H., additional, Fink, Jeffrey C., additional, Anderson, Amanda H., additional, Choi, Michael J., additional, Wright, Jackson T., additional, Lash, James P., additional, Freedman, Barry I., additional, Ojo, Akinlolu, additional, Winkler, Cheryl A., additional, Raj, Dominic S., additional, Kopp, Jeffrey B., additional, He, Jiang, additional, Jensvold, Nancy G., additional, Tao, Kaixiang, additional, Lipkowitz, Michael S., additional, and Appel, Lawrence J., additional

Published
2013
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222. Age of Onset and Disease Course in Biopsy-Proven Minimal Change Disease: An Analysis From the Cure Glomerulonephropathy Network

Author

Chen, Dhruti P., Helmuth, Margaret E., Smith, Abigail R., Canetta, Pietro A., Ayoub, Isabelle, Mucha, Krzysztof, Kallash, Mahmoud, Kopp, Jeffrey B., Gbadegesin, Rasheed, Gillespie, Brenda W., Greenbaum, Larry A., Parekh, Rulan S., Hunley, Tracy E., Sperati, C. John, Selewski, David T., Kidd, Jason, Chishti, Aftab, Reidy, Kimberly, Mottl, Amy K., Gipson, Debbie S., Srivastava, Tarak, Twombley, Katherine E., Ahn, Wooin, Appel, Gerald, Appelbaum, Paul, Babayev, Revekka, Bomback, Andrew, Chan, Brenda, D’Agati, Vivette Denise, Dogra, Samitri, Fernandez, Hilda, Gharavi, Ali, Hines, William, Husain, Syed Ali, Jain, Namrata, Kiryluk, Krzysztof, Lin, Fangming, Marasa, Maddalena, Markowitz, Glen, Rasouly, Hila Milo, Mohan, Sumit, Mongera, Nicola, Nestor, Jordan, Nickolas, Thomas, Radhakrishnan, Jai, Rao, Maya, Sanna-Cherchi, Simone, Shirazian, Shayan, Stokes, Michael Barry, Uy, Natalie, Valeri, Anthony, Vena, Natalie, Foroncewicz, Bartosz, Moszczuk, Barbara, Perkowska-Ptasińska, Agnieszka, Ghiggeri, Gian Marco, Lugani, Francesca, Ambruzs, Josephine, Liapis, Helen, Baracco, Rossana, Jain, Amrish, Ashoor, Isa, Aviles, Diego, Ahn, Sun-Young, Devarajan, Prasad, Erkan, Elif, Claes, Donna, Stone, Hillarey, Mason, Sherene, Gomez-Mendez, Liliana, Wang, Chia-shi, Yin, Hong, Cai, Yi, Jens, Goebel, Steinke, Julia, Weaver, Donald, Lane, Jerome, Cramer, Carl, Pan, Cindy, Paloian, Neil, Sreedharan, Rajasree, Bowers, Corinna, Dreher, Mary, Mahan, John, Sharpe, Samantha, Smoyer, William, Al-Uzri, Amira, Iragorri, Sandra, Khalid, Myda, Belsha, Craig, Alge, Joseph, Braun, Michael, Gomez, A.C., Wenderfer, Scott, Vasylyeva, Tetyana, Feig, Daniel, Fuentes, Gabriel Cara, Hannah, Melisha, Nester, Carla, Klein, Jon, Katsoufis, Chryso, Seeherunvong, Wacharee, Rheault, Michelle, Wong, Craig, Mathews, Nisha, Barcia, John, Swiatecka-Urban, Agnes, Bartosh, Sharon, Dharnidharka, Vikas, Gaut, Joseph, Laurin, Louis-Philippe, Royal, Virginie, Achanti, Anand, Budisavljevic, Milos, Self, Sally, Ghossein, Cybele, Peleg, Yonatan, Wadhwani, Shikha, Almaani, Salem, Nadasdy, Tibor, Samir, Parikh, Rovin, Brad, Chang, Anthony, Fatima, Huma, Julian, Bruce, Novak, Jan, Renfrow, Matthew, Rizk, Dana, Derebail, Vimal, Falk, Ronald, Gibson, Keisha, Glenn, Dorey, Hogan, Susan, Jain, Koyal, Jennette, J. Charles, Poulton, Caroline, Saha, Manish Kanti, Fogo, Agnes, Sanghani, Neil, Muthusamy, Selvaraj, Schelling, Jeffrey, Hou, Jean, Lemley, Kevin, Mika, Warren, Russo, Pierre, Denburg, Michelle, Kogon, Amy, Meyers, Kevin, Pradhan, Madhura, Matar, Raed Bou, O’Toole, John, Sedor, John, Sethna, Christine, Vento, Suzanne, Atta, Mohamed, Bagnasco, Serena, Neu, Alicia, Adler, Sharon, Dai, Tiane, Dukkipati, Ram, Fervenza, Fernando, Sethi, Sanjeev, Kaskel, Frederick, Brathwaite, Kaye, Weisstuch, Joseph, Wu, Ming, Zhdanova, Olga, Heymann, Jurgen, Waldman, Meryl, Winkler, Cheryl, Tuttle, Katherine, Krissberg, Jill, Lafayette, Richard, Fahmeedah, Kamal, Talley, Elizabeth, Hladunewich, Michelle, Avila-Casado, Carmen, Cattran, Daniel, Heather, Reich, Boll, Philip, Drexler, Yelena, Fornoni, Alessia, Gipson, Patrick, Hodgin, Jeffrey, Oliverio, Andrea, Hogan, Jon, Holzman, Lawrence, Palmer, Matthew, Coppock, Gaia, Abromovitz, Blaise, Mortiz, Michael, Alpers, Charles, Jefferson, J. Ashley, Brown, Elizabeth, Sambandam, Kamal, Roehm, Bethany, Robinson, Bruce, Nast, Cynthia, Barisoni, Laura, Kretzler, Matthias, Mariani, Laura, and Guay-Woodford, Lisa M.

Abstract

Adolescent- and adult-onset minimal change disease (MCD) may have a clinical course distinct from childhood-onset disease. We characterized the course of children and adults with MCD in the Cure Glomerulonephropathy Network (CureGN) and assessed predictors of rituximab response.

Published
2023
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223. 5-year-old girl with abdominal pain, headache, and cracked lips.

Author

Tran, My-An, Chad, Lauren, Parekh, Rulan S, and Bismilla, Zia

Subjects
ANTIBIOTICS, PHYSICAL diagnosis, FEVER, LYMPHADENITIS, EXANTHEMA, LUMBAR puncture, ABDOMINAL pain, HEADACHE, NECK, ROUTINE diagnostic tests, LIPS, EYE examination, ABDOMINAL radiography, PAPILLEDEMA
Abstract

The article reports that A previously healthy 5-year-old girl presented to the Emergency Room with a 2-week history of neck stiffness and rash, and a 4-day history of abdominal pain, headaches, low-grade fevers, and cracked lips. Parents were also concerned she was more irritable than usual She was unimmunized and on a strict vegan diet with Vitamin A, C, D, probiotics, and fish oil supplementation.

Published
2022
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224. Genomewide linkage scan for diabetic renal failure and albuminuria: the FIND study.

Author

Igo, Robert P, Jr, Igo, Robert P, Jr, Iyengar, Sudha K, Nicholas, Susanne B, Goddard, Katrina A B, Langefeld, Carl D, Hanson, Robert L, Duggirala, Ravindranath, Divers, Jasmin, Abboud, Hanna, Adler, Sharon G, Arar, Nedal H, Horvath, Amanda, Elston, Robert C, Bowden, Donald W, Guo, Xiuqing, Ipp, Eli, Kao, W H Linda, Kimmel, Paul L, Knowler, William C, Meoni, Lucy A, Molineros, Julio, Nelson, Robert G, Pahl, Madeline V, Parekh, Rulan S, Rasooly, Rebekah S, Schelling, Jeffrey R, Shah, Vallabh O, Smith, Michael W, Winkler, Cheryl A, Zager, Philip G, Sedor, John R, Freedman, Barry I, Igo, Robert P, Jr, Igo, Robert P, Jr, Iyengar, Sudha K, Nicholas, Susanne B, Goddard, Katrina A B, Langefeld, Carl D, Hanson, Robert L, Duggirala, Ravindranath, Divers, Jasmin, Abboud, Hanna, Adler, Sharon G, Arar, Nedal H, Horvath, Amanda, Elston, Robert C, Bowden, Donald W, Guo, Xiuqing, Ipp, Eli, Kao, W H Linda, Kimmel, Paul L, Knowler, William C, Meoni, Lucy A, Molineros, Julio, Nelson, Robert G, Pahl, Madeline V, Parekh, Rulan S, Rasooly, Rebekah S, Schelling, Jeffrey R, Shah, Vallabh O, Smith, Michael W, Winkler, Cheryl A, Zager, Philip G, Sedor, John R, and Freedman, Barry I

Abstract

Diabetic nephropathy (DN) is a leading cause of mortality and morbidity in patients with type 1 and type 2 diabetes. The multicenter FIND consortium aims to identify genes for DN and its associated quantitative traits, e.g. the urine albumin:creatinine ratio (ACR). Herein, the results of whole-genome linkage analysis and a sparse association scan for ACR and a dichotomous DN phenotype are reported in diabetic individuals.A genomewide scan comprising more than 5,500 autosomal single nucleotide polymorphism markers (average spacing of 0.6 cM) was performed on 1,235 nuclear and extended pedigrees (3,972 diabetic participants) ascertained for DN from African-American (AA), American-Indian (AI), European-American (EA) and Mexican-American (MA) populations.Strong evidence for linkage to DN was detected on chromosome 6p (p = 8.0 × 10(-5), LOD = 3.09) in EA families as well as suggestive evidence for linkage to chromosome 7p in AI families. Regions on chromosomes 3p in AA, 7q in EA, 16q in AA and 22q in MA displayed suggestive evidence of linkage for urine ACR. The linkage peak on chromosome 22q overlaps the MYH9/APOL1 gene region, previously implicated in AA diabetic and nondiabetic nephropathies.These results strengthen the evidence for previously identified genomic regions and implicate several novel loci potentially involved in the pathogenesis of DN.

Published
2011

227. Antiretroviral-Treated HIV-Infected Women Have Similar Long-Term Kidney Function Trajectories as HIV-Uninfected Women

Author

Estrella, Michelle M., primary, Abraham, Alison G., additional, Jing, Yuezhou, additional, Parekh, Rulan S., additional, Tien, Phyllis C., additional, Merenstein, Dan, additional, Pearce, Celeste Leigh, additional, Anastos, Kathryn, additional, Cohen, Mardge H., additional, Dehovitz, Jack A., additional, and Gange, Stephen J., additional

Published
2013
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228. CLINICAL PREDICTORS OF CORONARY ARTERY CALCIFICATION IN END-STAGE RENAL DISEASE PATIENTS: THE PACE (PREDICTORS OF ARRHYTHMIC AND CARDIOVASCULAR RISK IN END-STAGE RENAL DISEASE) STUDY

Author

Magalhaes, Tiago A., primary, Rizzi, Patricia B., additional, Meoni, Lucy, additional, Jaar, Bernard, additional, Sozio, Steve, additional, Estrella, Michelle, additional, Kao, Wen-Hong, additional, Santaularia-Tomas, Miguel, additional, Lima, Joao A., additional, and Parekh, Rulan S., additional

Published
2013
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229. The rationale and design of Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT): a prospective cohort study of childhood nephrotic syndrome

Author

Hussain, Neesha, primary, Zello, J Anastasia, additional, Vasilevska-Ristovska, Jovanka, additional, Banh, Tonny M, additional, Patel, Viral P, additional, Patel, Pranali, additional, Battiston, Christopher D, additional, Hebert, Diane, additional, Licht, Christoph P B, additional, Piscione, Tino D, additional, and Parekh, Rulan S, additional

Published
2013
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231. Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans

Author

Lipkowitz, Michael S., primary, Freedman, Barry I., additional, Langefeld, Carl D., additional, Comeau, Mary E., additional, Bowden, Donald W., additional, Linda Kao, W.H., additional, Astor, Brad C., additional, Bottinger, Erwin P., additional, Iyengar, Sudha K., additional, Klotman, Paul E., additional, Freedman, Richard G., additional, Zhang, Weijia, additional, Parekh, Rulan S., additional, Choi, Michael J., additional, Nelson, George W., additional, Winkler, Cheryl A., additional, and Kopp, Jeffrey B., additional

Published
2013
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232. Neoral induction in pediatric renal transplantation

Author

Division of Pediatric Nephrology, University of Michigan, Michigan, USA, US, Ann Arbor, Kershaw, David B., Sandvordenker, Jill, Brown, Catherine, Parekh, Rulan S., Pontillo, Brenda J., Smoyer, William E., Flynn, Joseph T., Valentini, Rudolph P., Bunchman, Timothy E., Sedman, Aileen B., Division of Pediatric Nephrology, University of Michigan, Michigan, USA, US, Ann Arbor, Kershaw, David B., Sandvordenker, Jill, Brown, Catherine, Parekh, Rulan S., Pontillo, Brenda J., Smoyer, William E., Flynn, Joseph T., Valentini, Rudolph P., Bunchman, Timothy E., and Sedman, Aileen B.

Abstract

Neoral was instituted in pediatric renal transplant patients with the hypothesis it would have more predictable kinetics than Sandimmun. However, significant questions have arisen concerning potential toxicity and dosing interval related to its rapid absorption with subsequent high initial peak. This is compounded by the fact that children appear to metabolize cyclosporine at a greater rate than adults. This combination of a rapid peak and rapid absorption may then result in lower trough levels at 12 h. We compared the trough cyclosporine levels of nine children who received Neoral with nine who received Sandimmun at the time of initial transplantation. More frequent dosing (every 8 h) was required in the Neoral population compared with the Sandimmun population for the 1st month in order to obtain comparable trough levels. Beyond the initial 4???6 weeks, trough levels were similar for Neoral and Sandimmun. Whereas 1-month creatinine levels and blood pressures were similar, the number of blood pressure medications was significantly higher in the Neoral group. At 5.5?? 1.1 months??? followup, a single patient in the current Neoral group and in the retrospective Sandimmun group each experienced a single OKT3 allograft-treated rejection. We suggest that the area under the curve is different in Neoral than Sandimmun, and the initial dosing frequency may need to be adjusted accordingly.

Published
2006

235. Genetic Association and Gene-Gene Interaction Analyses in African American Dialysis Patients With Nondiabetic Nephropathy

Author

Bostrom, Meredith A., primary, Kao, W.H. Linda, additional, Li, Man, additional, Abboud, Hanna E., additional, Adler, Sharon G., additional, Iyengar, Sudha K., additional, Kimmel, Paul L., additional, Hanson, Robert L., additional, Nicholas, Susanne B., additional, Rasooly, Rebekah S., additional, Sedor, John R., additional, Coresh, Josef, additional, Kohn, Orly F., additional, Leehey, David J., additional, Thornley-Brown, Denyse, additional, Bottinger, Erwin P., additional, Lipkowitz, Michael S., additional, Meoni, Lucy A., additional, Klag, Michael J., additional, Lu, Lingyi, additional, Hicks, Pamela J., additional, Langefeld, Carl D., additional, Parekh, Rulan S., additional, Bowden, Donald W., additional, and Freedman, Barry I., additional

Published
2012
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236. Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease

Author

Krissberg, Jill R., O’Shaughnessy, Michelle M., Smith, Abigail R., Helmuth, Margaret E., Almaani, Salem, Aviles, Diego H., Brathwaite, Kaye E., Cai, Yi, Cattran, Daniel, Gbadegesin, Rasheed, Glenn, Dorey A., Greenbaum, Larry A., Iragorri, Sandra, Jain, Koyal, Khalid, Myda, Kidd, Jason, Kopp, Jeffrey, Lafayette, Richard, Lane, Jerome C., Lugani, Francesca, Nestor, Jordan G., Parekh, Rulan S., Reidy, Kimberly, Selewski, David T., Sethna, Christine B., Sperati, C. John, Tuttle, Katherine, Twombley, Katherine, Vasylyeva, Tetyana L., Weaver, Donald J., Wenderfer, Scott E., Gibson, Keisha, Ahn, Wooin, Appel, Gerald, Appelbaum, Paul, Babayev, Revekka, Bomback, Andrew, Brown, Eric, Canetta, Pietro, Carlassara, Lucrezia, Chan, Brenda, D’Agati, Vivette Denise, Dogra, Samitri, Fernandez, Hilda, Gharavi, Ali, Hines, William, Husain, Syed Ali, Kiryluk, Krzysztof, Lin, Fangming, Marasa, Maddalena, Markowitz, Glen, Rasouly, Hila Milo, Mohan, Sumit, Mongera, Nicola, Nickolas, Thomas, Radhakrishnan, Jai, Rao, Maya, Sanna-Cherchi, Simone, Shirazian, Shayan, Stokes, Michael Barry, Uy, Natalie, Valeri, Anthony, Vena, Natalie, Foroncewicz, Bartosz, Moszczuk, Barbara, Mucha, Krzysztof, Perkowska-Ptasińska, Agnieszka, Ghiggeri, Gian Marco, Ambruzs, Josephine, Liapis, Helen, Baracco, Rossana, Jain, Amrish, Ashoor, Isa, Srivastava, Tarak, Ahn, Sun-Young, Devarajan, Prasad, Erkan, Elif, Claes, Donna, Stone, Hillarey, Mason, Sherene, Silva, Cynthia, Gomez-Mendez, Liliana, Wang, Chia-shi, Yin, Hong (Julie), Jens, Goebel, Steinke, Julia, Cramer, Carl, Pan, Cindy, Sreedharan, Rajasree, Bowers, Corinna, Dreher, Mary, Kallash, Mahmoud, Mahan, John, Sharpe, Samantha, Smoyer, William, Al-Uzri, Amira, Belsha, Craig, Braun, Michael, Gomez, A.C., Feig, Daniel, Fuentes, Gabriel Cara, Hannah, Melisha, Nester, Carla, Chishti, Aftab, Klein, Jon, Katsoufis, Chryso, Seeherunvong, Wacharee, Rheault, Michelle, Wong, Craig, Mathews, Nisha, Barcia, John, Swiatecka-Urban, Agnes, Bartosh, Sharon, Hunley, Tracy, Dharnidharka, Vikas, Gaut, Joseph, Laurin, Louis-Philippe, Royal, Virginie, Achanti, Anand, Budisavljevic, Milos, Self, Sally, Ghossein, Cybele, Wadhwani, Shikha, Ayoub, Isabelle, Nadasdy, Tibor, Parikh, Samir, Rovin, Brad, Chang, Anthony, Fatima, Huma, Novak, Jan, Renfrow, Matthew, Rizk, Dana, Chen, Dhruti, Derebail, Vimal, Falk, Ronald, Gibson, Keisha, Hogan, Susan, Jain, Koyal, Jennette, J. Charles, Mottl, Amy, Poulton, Caroline, Saha, Manish Kanti, Fogo, Agnes, Sanghani, Neil, Kidd, Jason, Massey, Hugh, Muthusamy, Selvaraj, Ganesan, Santhi, Gonzalez-Vicente, Agustin, Schelling, Jeffrey, Hou, Jean, Lemley, Kevin, Mika, Warren, Russo, Pierre, Denburg, Michelle, Kogon, Amy, Meyers, Kevin, Pradhan, Madhura, Matar, Raed Bou, O’Toole, John, Sedor, John, Bagnasco, Serena, Neu, Alicia, Adler, Sharon, Dai, Tiane, Dukkipati, Ram, Fervenza, Fernando, Sethi, Sanjeev, Kaskel, Frederick, Vento, Suzanne, Weisstuch, Joseph, Wu, Ming, Zhdanova, Olga, Heymann, Jurgen, Waldman, Meryl, Winkler, Cheryl, Hladunewich, Michelle, Avila-Casado, Carmen, Cattran, Daniel, Heather, Reich, Boll, Philip, Drexler, Yelena, Fornoni, Alessia, Gipson, Patrick, Hodgin, Jeffrey, Oliverio, Andrew, Hogan, Jon, Holzman, Lawrence, Palmer, Matthew, Abromovitz, Blaise, Mortiz, Michael, Alpers, Charles, Jefferson, J. Ashley, Brown, Elizabeth, Sambandam, Kamal, Robinson, Bruce, Nast, Cynthia, Barisoni, Laura, Gillespie, Brenda, Gipson, Deb, Hicken, Maggie, Kretzler, Matthias, Mariani, Laura, and Guay-Woodford, Lisa M.

Abstract

The effects of race, ethnicity, socioeconomic status (SES), and disease severity on acute care utilization in patients with glomerular disease are unknown.

Published
2023
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239. Correlates of Osteoprotegerin and Association with Aortic Pulse Wave Velocity in Patients with Chronic Kidney Disease

Author

Scialla, Julia J., primary, Leonard, Mary B., additional, Townsend, Raymond R., additional, Appel, Lawrence, additional, Wolf, Myles, additional, Budoff, Matt J., additional, Chen, Jing, additional, Lustigova, Eva, additional, Gadegbeku, Crystal A., additional, Glenn, Melanie, additional, Hanish, Asaf, additional, Raj, Dominic, additional, Rosas, Sylvia E., additional, Seliger, Stephen L., additional, Weir, Matthew R., additional, and Parekh, Rulan S., additional

Published
2011
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245. The Impact of Kidney Function at Highly Active Antiretroviral Therapy Initiation on Mortality in HIV-Infected Women

Author

Estrella, Michelle M, primary, Parekh, Rulan S, additional, Abraham, Alison, additional, Astor, Brad C, additional, Szczech, Lynda A, additional, Anastos, Kathryn, additional, Dehovitz, Jack A, additional, Merenstein, Daniel J, additional, Pearce, C Leigh, additional, Tien, Phyllis C, additional, Cohen, Mardge H, additional, and Gange, Stephen J, additional

Published
2010
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250. Genome‐wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations—significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group

Author

Malhotra, Alka, primary, Igo Jr, Robert P., additional, Thameem, Farook, additional, Kao, W. H. Linda, additional, Abboud, Hanna E., additional, Adler, Sharon G., additional, Arar, Nedal H., additional, Bowden, Donald W., additional, Duggirala, Ravindranath, additional, Freedman, Barry I., additional, Goddard, Katrina A. B., additional, Ipp, Eli, additional, Iyengar, Sudha K., additional, Kimmel, Paul L., additional, Knowler, William C., additional, Kohn, Orly, additional, Leehey, David, additional, Meoni, Lucy A., additional, Nelson, Robert G., additional, Nicholas, Susanne B., additional, Parekh, Rulan S., additional, Rich, Stephen S., additional, Chen, Yii‐Der I., additional, Saad, Mohammed F., additional, Scavini, Marina, additional, Schelling, Jeffrey R., additional, Sedor, John R., additional, Shah, Vallabh O., additional, Taylor, Kent D., additional, Thornley‐Brown, Denyse, additional, Zager, Philip G., additional, Horvath, Amanda, additional, and Hanson, Robert L., additional

Published
2009
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