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205. Revista de psicología y educación

Author

Simos, Panagiotis G., Fernández, Magdalena, Papanicolaou, Andrew C., and Catillo, Eduardo M.

Subjects
dislexia, fonología, lectura, educación de la primera infancia, neurofisiología
Abstract

Título, resumen, palabras clave en español y portugués Resumen basado en el de la publicación Se describe como en niños disléxicos se sospecha un déficit funcional del circuito cerebral implicado en algunos de los procesos que acaecen cuando aprenden la relación entre la conversión del grafema al fonema. Tres han sido los estudios que han servido para abordar factores clave en esta condición, mediante el empleo de la Magnetoencefalografía (MEG) en la Universidad de Texas –Houston. El primer estudio, en el que se incluyeron 30 niños en edad pre-escolar en riesgo de padecer problemas lectores y 15 controles sin riesgo de padecerlos, se comprobó que el circuito neuronal aberrante característico en los problemas lectores es aparente en los primeros estadios de la adquisición de habilidades lectoras. Un grupo de estos niños se estudiaron un año después con el mismo procedimiento en un segundo estudio. Los niños en riesgo de padecer problemas lectores mostraron un perfil de activación cerebral destacado que predecía diferencias individuales en las pruebas de habilidades lectoras. Un tercer estudio mostró una clara tendencia a la corrección del patrón de activación cerebral anormal tras una intervención cognitiva intensiva de los niños. Estos hallazgos son consistentes con la perspectiva de que la dislexia constituye un déficit funcional en el circuito neuronal implicado en la conversión del grafema al fonema, y que es susceptible de ser corregido con una intervención adecuada. ESP

Published
2008

247. Neuroimaging Features of Epidermal Nevus Syndrome

Author

Zhang, Wenbo, Simos, Panagiotis G., Ishibashi, Hideaki, Wheless, James W., Castillo, Eduardo M., Breier, Joshua I, Baumgartner, James E., Fitzgerald, Michele E., and Papanicolaou, Andrew C.

Subjects
Pediatric, Central Nervous System, Male, Tomography, Emission-Computed, Single-Photon, Neurocutaneous Syndromes, Infant, Magnetoencephalography, Magnetic Resonance Imaging, Radiography, Seizures, Child, Preschool, Humans, Abnormalities, Multiple, Female, Epidermis
Abstract

Summary: Epidermal nevus syndrome is a kind of neurocutaneous syndrome that is associated with epidermal nevus and a variety of congenital CNS disorders. Clinical presentations include seizures, paresis, mental retardation, and developmental delay. We report three cases with MR imaging and magnetoencephalography findings; one patient underwent ictal and interictal single photon emission CT. Both structural and functional imaging studies indicated that the frontal lobes had lesser involvement or were intact. One patient underwent hemispherectomy because of the medically intractable seizure. He remained seizure free with topiramate monotherapy.

Published
2003

249. The Mission Connect Translational MTBI Translational Research Consortium

Author

TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON, Papanicolaou, Andrew C., TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON, and Papanicolaou, Andrew C.

Abstract

In this study we use Magnetoencephalography (MEG) to detect and characterize focal abnormalities in neurophysiological function in patients with mTBI and PTSD for the purpose of distinguishing between the two. MEG is a completely non-invasive imaging modality which is able to provide information regarding focal abnormalities in the brain. MEG has been shown to be sensitive to cognitive complaints in patients with mTBI. In addition neurophysiological abnormalities differentiate patients with mTBI and PTSD in some studies. We are also exploring the relationship between diffusion tensor imaging (DTI) and MEG findings. While MEG provides data regarding focal abnormalities in neural response in the cortex, DTI reveals the status of white matter tracts that form the intracortical connections. Thus, MEG, in combination with DTI, may lead to identification of more distinct, replicable patterns of brain abnormalities in subjects with PTSD and mTBI that may lead to better differentiation between these groups of patients, as well as from patients with a combination of both disorders.

Published
2010

250. The Mission Connect Mild TBI Translational Research Consortium

Author

TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON, Papanicolaou, Andrew C., TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON, and Papanicolaou, Andrew C.

Abstract

In this study we propose to use magnetoencephalography (MEG) to detect and characterize focal abnormalities in neurophysiological function in patients with mTBI and PTSD for the purpose of distinguishing between the two. MEG is a completely non-invasive imaging modality which is able to provide information regarding focal abnormalities in the brain. MEG has been shown to be sensitive to cognitive complaints in patients with mTBI. In addition neurophysiological abnormalities differentiate patients with mTBI and PTSD in some studies. We also propose to explore the relationship between diffusion tensor imaging (DTI) and MEG findings. While MEG provides data regarding focal abnormalities in neural response in the cortex, DTI reveals the status of white matter tracts that form the intracortical connections. Thus, MEG, in combination with DTI, may lead to identification of more distinct, replicable patterns of brain abnormalities in subjects with PTSD and mTBI that may lead to better differentiation between these groups of patients, as well as from patients with a combination of both disorders. We continue to await approval to begin to collect data from patients at this time.

Published
2009

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