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201. Supplementary table 1 from Circulating DNA and Survival in Solid Tumors

Author

Ocaña, Alberto, primary, Díez-González, Laura, primary, García-Olmo, Dolores C., primary, Templeton, Arnoud J., primary, Vera-Badillo, Francisco, primary, José Escribano, María, primary, Serrano-Heras, Gemma, primary, Corrales-Sánchez, Verónica, primary, Seruga, Bostjan, primary, Andrés-Pretel, Fernando, primary, Pandiella, Atanasio, primary, and Amir, Eitan, primary

Published
2023
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204. Supplementary Figure 6 from NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia

Author

Sánchez-Sánchez, Beatriz, primary, Gutiérrez-Herrero, Sara, primary, López-Ruano, Guillermo, primary, Prieto-Bermejo, Rodrigo, primary, Romo-González, Marta, primary, Llanillo, Marcial, primary, Pandiella, Atanasio, primary, Guerrero, Carmen, primary, Miguel, Jesús F. San, primary, Sánchez-Guijo, Fermín, primary, del Cañizo, Consuelo, primary, and Hernández-Hernández, Angel, primary

Published
2023
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206. Supplementary Figure 8 from NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia

Author

Sánchez-Sánchez, Beatriz, primary, Gutiérrez-Herrero, Sara, primary, López-Ruano, Guillermo, primary, Prieto-Bermejo, Rodrigo, primary, Romo-González, Marta, primary, Llanillo, Marcial, primary, Pandiella, Atanasio, primary, Guerrero, Carmen, primary, Miguel, Jesús F. San, primary, Sánchez-Guijo, Fermín, primary, del Cañizo, Consuelo, primary, and Hernández-Hernández, Angel, primary

Published
2023
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207. Supplementary Figure S1 from Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer

Author

Duro-Sánchez, Santiago, primary, Nadal-Serrano, Mercedes, primary, Lalinde-Gutiérrez, Marta, primary, Arenas, Enrique Javier, primary, Bernadó Morales, Cristina, primary, Morancho, Beatriz, primary, Escorihuela, Marta, primary, Pérez-Ramos, Sandra, primary, Escrivá-de-Romaní, Santiago, primary, Gandullo-Sánchez, Lucía, primary, Pandiella, Atanasio, primary, Esteve-Codina, Anna, primary, Rodilla, Verónica, primary, Dijcks, Fred A., primary, Dokter, Wim H.A., primary, Cortés, Javier, primary, Saura, Cristina, primary, and Arribas, Joaquín, primary

Published
2023
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208. Supplementary Materials and Figure Legends from Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer

Author

Duro-Sánchez, Santiago, primary, Nadal-Serrano, Mercedes, primary, Lalinde-Gutiérrez, Marta, primary, Arenas, Enrique Javier, primary, Bernadó Morales, Cristina, primary, Morancho, Beatriz, primary, Escorihuela, Marta, primary, Pérez-Ramos, Sandra, primary, Escrivá-de-Romaní, Santiago, primary, Gandullo-Sánchez, Lucía, primary, Pandiella, Atanasio, primary, Esteve-Codina, Anna, primary, Rodilla, Verónica, primary, Dijcks, Fred A., primary, Dokter, Wim H.A., primary, Cortés, Javier, primary, Saura, Cristina, primary, and Arribas, Joaquín, primary

Published
2023
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209. Supplementary Figure Legends from NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia

Author

Sánchez-Sánchez, Beatriz, primary, Gutiérrez-Herrero, Sara, primary, López-Ruano, Guillermo, primary, Prieto-Bermejo, Rodrigo, primary, Romo-González, Marta, primary, Llanillo, Marcial, primary, Pandiella, Atanasio, primary, Guerrero, Carmen, primary, Miguel, Jesús F. San, primary, Sánchez-Guijo, Fermín, primary, del Cañizo, Consuelo, primary, and Hernández-Hernández, Angel, primary

Published
2023
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210. Supplementary Figure 5 from NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia

Author

Sánchez-Sánchez, Beatriz, primary, Gutiérrez-Herrero, Sara, primary, López-Ruano, Guillermo, primary, Prieto-Bermejo, Rodrigo, primary, Romo-González, Marta, primary, Llanillo, Marcial, primary, Pandiella, Atanasio, primary, Guerrero, Carmen, primary, Miguel, Jesús F. San, primary, Sánchez-Guijo, Fermín, primary, del Cañizo, Consuelo, primary, and Hernández-Hernández, Angel, primary

Published
2023
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211. Supplementary Figure 3 from NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia

Author

Sánchez-Sánchez, Beatriz, primary, Gutiérrez-Herrero, Sara, primary, López-Ruano, Guillermo, primary, Prieto-Bermejo, Rodrigo, primary, Romo-González, Marta, primary, Llanillo, Marcial, primary, Pandiella, Atanasio, primary, Guerrero, Carmen, primary, Miguel, Jesús F. San, primary, Sánchez-Guijo, Fermín, primary, del Cañizo, Consuelo, primary, and Hernández-Hernández, Angel, primary

Published
2023
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212. Supplementary Figure 4 from NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia

Author

Sánchez-Sánchez, Beatriz, primary, Gutiérrez-Herrero, Sara, primary, López-Ruano, Guillermo, primary, Prieto-Bermejo, Rodrigo, primary, Romo-González, Marta, primary, Llanillo, Marcial, primary, Pandiella, Atanasio, primary, Guerrero, Carmen, primary, Miguel, Jesús F. San, primary, Sánchez-Guijo, Fermín, primary, del Cañizo, Consuelo, primary, and Hernández-Hernández, Angel, primary

Published
2023
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213. Supplementary Figure 7 from NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia

Author

Sánchez-Sánchez, Beatriz, primary, Gutiérrez-Herrero, Sara, primary, López-Ruano, Guillermo, primary, Prieto-Bermejo, Rodrigo, primary, Romo-González, Marta, primary, Llanillo, Marcial, primary, Pandiella, Atanasio, primary, Guerrero, Carmen, primary, Miguel, Jesús F. San, primary, Sánchez-Guijo, Fermín, primary, del Cañizo, Consuelo, primary, and Hernández-Hernández, Angel, primary

Published
2023
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214. Supplementary Tables from Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer

Author

Duro-Sánchez, Santiago, primary, Nadal-Serrano, Mercedes, primary, Lalinde-Gutiérrez, Marta, primary, Arenas, Enrique Javier, primary, Bernadó Morales, Cristina, primary, Morancho, Beatriz, primary, Escorihuela, Marta, primary, Pérez-Ramos, Sandra, primary, Escrivá-de-Romaní, Santiago, primary, Gandullo-Sánchez, Lucía, primary, Pandiella, Atanasio, primary, Esteve-Codina, Anna, primary, Rodilla, Verónica, primary, Dijcks, Fred A., primary, Dokter, Wim H.A., primary, Cortés, Javier, primary, Saura, Cristina, primary, and Arribas, Joaquín, primary

Published
2023
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216. Supplementary Figure 1 from Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer

Author

Guardia, Cristina, primary, Bianchini, Giampaolo, primary, Arpí-LLucià, Oriol, primary, Menendez, Silvia, primary, Casadevall, David, primary, Galbardi, Barbara, primary, Dugo, Matteo, primary, Servitja, Sonia, primary, Montero, Juan Carlos, primary, Soria-Jiménez, Luis, primary, Sabbaghi, MohammadA, primary, Peña, Raul, primary, Madoz-Gúrpide, Juan, primary, Lloveras, Belen, primary, Lluch, Ana, primary, Eroles, Pilar, primary, Arribas, Joaquin, primary, Pandiella, Atanasio, primary, Gianni, Luca, primary, Rojo, Federico, primary, Rovira, Ana, primary, and Albanell, Joan, primary

Published
2023
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217. Supplementary Figure 2 from NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia

Author

Sánchez-Sánchez, Beatriz, primary, Gutiérrez-Herrero, Sara, primary, López-Ruano, Guillermo, primary, Prieto-Bermejo, Rodrigo, primary, Romo-González, Marta, primary, Llanillo, Marcial, primary, Pandiella, Atanasio, primary, Guerrero, Carmen, primary, Miguel, Jesús F. San, primary, Sánchez-Guijo, Fermín, primary, del Cañizo, Consuelo, primary, and Hernández-Hernández, Angel, primary

Published
2023
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218. Supplementary Figure 2 from Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer

Author

Guardia, Cristina, primary, Bianchini, Giampaolo, primary, Arpí-LLucià, Oriol, primary, Menendez, Silvia, primary, Casadevall, David, primary, Galbardi, Barbara, primary, Dugo, Matteo, primary, Servitja, Sonia, primary, Montero, Juan Carlos, primary, Soria-Jiménez, Luis, primary, Sabbaghi, MohammadA, primary, Peña, Raul, primary, Madoz-Gúrpide, Juan, primary, Lloveras, Belen, primary, Lluch, Ana, primary, Eroles, Pilar, primary, Arribas, Joaquin, primary, Pandiella, Atanasio, primary, Gianni, Luca, primary, Rojo, Federico, primary, Rovira, Ana, primary, and Albanell, Joan, primary

Published
2023
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219. Supplementary Figure 1 from NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia

Author

Sánchez-Sánchez, Beatriz, primary, Gutiérrez-Herrero, Sara, primary, López-Ruano, Guillermo, primary, Prieto-Bermejo, Rodrigo, primary, Romo-González, Marta, primary, Llanillo, Marcial, primary, Pandiella, Atanasio, primary, Guerrero, Carmen, primary, Miguel, Jesús F. San, primary, Sánchez-Guijo, Fermín, primary, del Cañizo, Consuelo, primary, and Hernández-Hernández, Angel, primary

Published
2023
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220. Supplementary Figure 2 from Defective Cyclin B1 Induction in Trastuzumab-emtansine (T-DM1) Acquired Resistance in HER2-positive Breast Cancer

Author

Sabbaghi, MohammadA, primary, Gil-Gómez, Gabriel, primary, Guardia, Cristina, primary, Servitja, Sonia, primary, Arpí, Oriol, primary, García-Alonso, Sara, primary, Menendez, Silvia, primary, Arumi-Uria, Montserrat, primary, Serrano, Laia, primary, Salido, Marta, primary, Muntasell, Aura, primary, Martínez-García, Maria, primary, Zazo, Sandra, primary, Chamizo, Cristina, primary, González-Alonso, Paula, primary, Madoz-Gúrpide, Juan, primary, Eroles, Pilar, primary, Arribas, Joaquin, primary, Tusquets, Ignasi, primary, Lluch, Ana, primary, Pandiella, Atanasio, primary, Rojo, Federico, primary, Rovira, Ana, primary, and Albanell, Joan, primary

Published
2023
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221. Supplementary Figure 4 from Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer

Author

Guardia, Cristina, primary, Bianchini, Giampaolo, primary, Arpí-LLucià, Oriol, primary, Menendez, Silvia, primary, Casadevall, David, primary, Galbardi, Barbara, primary, Dugo, Matteo, primary, Servitja, Sonia, primary, Montero, Juan Carlos, primary, Soria-Jiménez, Luis, primary, Sabbaghi, MohammadA, primary, Peña, Raul, primary, Madoz-Gúrpide, Juan, primary, Lloveras, Belen, primary, Lluch, Ana, primary, Eroles, Pilar, primary, Arribas, Joaquin, primary, Pandiella, Atanasio, primary, Gianni, Luca, primary, Rojo, Federico, primary, Rovira, Ana, primary, and Albanell, Joan, primary

Published
2023
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222. Supplementary figures from Circulating DNA and Survival in Solid Tumors

Author

Ocaña, Alberto, primary, Díez-González, Laura, primary, García-Olmo, Dolores C., primary, Templeton, Arnoud J., primary, Vera-Badillo, Francisco, primary, José Escribano, María, primary, Serrano-Heras, Gemma, primary, Corrales-Sánchez, Verónica, primary, Seruga, Bostjan, primary, Andrés-Pretel, Fernando, primary, Pandiella, Atanasio, primary, and Amir, Eitan, primary

Published
2023
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223. Supplementary Figure 3 from Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer

Author

Guardia, Cristina, primary, Bianchini, Giampaolo, primary, Arpí-LLucià, Oriol, primary, Menendez, Silvia, primary, Casadevall, David, primary, Galbardi, Barbara, primary, Dugo, Matteo, primary, Servitja, Sonia, primary, Montero, Juan Carlos, primary, Soria-Jiménez, Luis, primary, Sabbaghi, MohammadA, primary, Peña, Raul, primary, Madoz-Gúrpide, Juan, primary, Lloveras, Belen, primary, Lluch, Ana, primary, Eroles, Pilar, primary, Arribas, Joaquin, primary, Pandiella, Atanasio, primary, Gianni, Luca, primary, Rojo, Federico, primary, Rovira, Ana, primary, and Albanell, Joan, primary

Published
2023
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224. Supplementary Table 1 from Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer

Author

Guardia, Cristina, primary, Bianchini, Giampaolo, primary, Arpí-LLucià, Oriol, primary, Menendez, Silvia, primary, Casadevall, David, primary, Galbardi, Barbara, primary, Dugo, Matteo, primary, Servitja, Sonia, primary, Montero, Juan Carlos, primary, Soria-Jiménez, Luis, primary, Sabbaghi, MohammadA, primary, Peña, Raul, primary, Madoz-Gúrpide, Juan, primary, Lloveras, Belen, primary, Lluch, Ana, primary, Eroles, Pilar, primary, Arribas, Joaquin, primary, Pandiella, Atanasio, primary, Gianni, Luca, primary, Rojo, Federico, primary, Rovira, Ana, primary, and Albanell, Joan, primary

Published
2023
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225. Supplementary Data from Induction of B-Chronic Lymphocytic Leukemia Cell Apoptosis by Arsenic Trioxide Involves Suppression of the Phosphoinositide 3-Kinase/Akt Survival Pathway via c-jun-NH2 Terminal Kinase Activation and PTEN Upregulation

Author

Redondo-Muñoz, Javier, primary, Escobar-Díaz, Elizabeth, primary, Hernández del Cerro, Mercedes, primary, Pandiella, Atanasio, primary, Terol, María José, primary, García-Marco, José A., primary, and García-Pardo, Angeles, primary

Published
2023
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226. Supplementary Table 2 from Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer

Author

Guardia, Cristina, primary, Bianchini, Giampaolo, primary, Arpí-LLucià, Oriol, primary, Menendez, Silvia, primary, Casadevall, David, primary, Galbardi, Barbara, primary, Dugo, Matteo, primary, Servitja, Sonia, primary, Montero, Juan Carlos, primary, Soria-Jiménez, Luis, primary, Sabbaghi, MohammadA, primary, Peña, Raul, primary, Madoz-Gúrpide, Juan, primary, Lloveras, Belen, primary, Lluch, Ana, primary, Eroles, Pilar, primary, Arribas, Joaquin, primary, Pandiella, Atanasio, primary, Gianni, Luca, primary, Rojo, Federico, primary, Rovira, Ana, primary, and Albanell, Joan, primary

Published
2023
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227. Supplementary Methods from NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia

Author

Sánchez-Sánchez, Beatriz, primary, Gutiérrez-Herrero, Sara, primary, López-Ruano, Guillermo, primary, Prieto-Bermejo, Rodrigo, primary, Romo-González, Marta, primary, Llanillo, Marcial, primary, Pandiella, Atanasio, primary, Guerrero, Carmen, primary, Miguel, Jesús F. San, primary, Sánchez-Guijo, Fermín, primary, del Cañizo, Consuelo, primary, and Hernández-Hernández, Angel, primary

Published
2023
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228. Supplementary Figure 8 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo

Author

Mitsiades, Constantine S., primary, Ocio, Enrique M., primary, Pandiella, Atanasio, primary, Maiso, Patricia, primary, Gajate, Consuelo, primary, Garayoa, Mercedes, primary, Vilanova, David, primary, Montero, Juan Carlos, primary, Mitsiades, Nicholas, primary, McMullan, Ciaran J., primary, Munshi, Nikhil C., primary, Hideshima, Teru, primary, Chauhan, Dharminder, primary, Aviles, Pablo, primary, Otero, Gabriel, primary, Faircloth, Glynn, primary, Mateos, M. Victoria, primary, Richardson, Paul G., primary, Mollinedo, Faustino, primary, San-Miguel, Jesus F., primary, and Anderson, Kenneth C., primary

Published
2023
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229. Supplementary Figure 3b from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo

Author

Mitsiades, Constantine S., primary, Ocio, Enrique M., primary, Pandiella, Atanasio, primary, Maiso, Patricia, primary, Gajate, Consuelo, primary, Garayoa, Mercedes, primary, Vilanova, David, primary, Montero, Juan Carlos, primary, Mitsiades, Nicholas, primary, McMullan, Ciaran J., primary, Munshi, Nikhil C., primary, Hideshima, Teru, primary, Chauhan, Dharminder, primary, Aviles, Pablo, primary, Otero, Gabriel, primary, Faircloth, Glynn, primary, Mateos, M. Victoria, primary, Richardson, Paul G., primary, Mollinedo, Faustino, primary, San-Miguel, Jesus F., primary, and Anderson, Kenneth C., primary

Published
2023
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230. Supplementary Table 1 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo

Author

Mitsiades, Constantine S., primary, Ocio, Enrique M., primary, Pandiella, Atanasio, primary, Maiso, Patricia, primary, Gajate, Consuelo, primary, Garayoa, Mercedes, primary, Vilanova, David, primary, Montero, Juan Carlos, primary, Mitsiades, Nicholas, primary, McMullan, Ciaran J., primary, Munshi, Nikhil C., primary, Hideshima, Teru, primary, Chauhan, Dharminder, primary, Aviles, Pablo, primary, Otero, Gabriel, primary, Faircloth, Glynn, primary, Mateos, M. Victoria, primary, Richardson, Paul G., primary, Mollinedo, Faustino, primary, San-Miguel, Jesus F., primary, and Anderson, Kenneth C., primary

Published
2023
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231. Supplementary Methods, Figure Legends 1-8 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo

Author

Mitsiades, Constantine S., primary, Ocio, Enrique M., primary, Pandiella, Atanasio, primary, Maiso, Patricia, primary, Gajate, Consuelo, primary, Garayoa, Mercedes, primary, Vilanova, David, primary, Montero, Juan Carlos, primary, Mitsiades, Nicholas, primary, McMullan, Ciaran J., primary, Munshi, Nikhil C., primary, Hideshima, Teru, primary, Chauhan, Dharminder, primary, Aviles, Pablo, primary, Otero, Gabriel, primary, Faircloth, Glynn, primary, Mateos, M. Victoria, primary, Richardson, Paul G., primary, Mollinedo, Faustino, primary, San-Miguel, Jesus F., primary, and Anderson, Kenneth C., primary

Published
2023
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232. Supplementary Figure 2 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo

Author

Mitsiades, Constantine S., primary, Ocio, Enrique M., primary, Pandiella, Atanasio, primary, Maiso, Patricia, primary, Gajate, Consuelo, primary, Garayoa, Mercedes, primary, Vilanova, David, primary, Montero, Juan Carlos, primary, Mitsiades, Nicholas, primary, McMullan, Ciaran J., primary, Munshi, Nikhil C., primary, Hideshima, Teru, primary, Chauhan, Dharminder, primary, Aviles, Pablo, primary, Otero, Gabriel, primary, Faircloth, Glynn, primary, Mateos, M. Victoria, primary, Richardson, Paul G., primary, Mollinedo, Faustino, primary, San-Miguel, Jesus F., primary, and Anderson, Kenneth C., primary

Published
2023
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233. Supplementary Figure 5 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo

Author

Mitsiades, Constantine S., primary, Ocio, Enrique M., primary, Pandiella, Atanasio, primary, Maiso, Patricia, primary, Gajate, Consuelo, primary, Garayoa, Mercedes, primary, Vilanova, David, primary, Montero, Juan Carlos, primary, Mitsiades, Nicholas, primary, McMullan, Ciaran J., primary, Munshi, Nikhil C., primary, Hideshima, Teru, primary, Chauhan, Dharminder, primary, Aviles, Pablo, primary, Otero, Gabriel, primary, Faircloth, Glynn, primary, Mateos, M. Victoria, primary, Richardson, Paul G., primary, Mollinedo, Faustino, primary, San-Miguel, Jesus F., primary, and Anderson, Kenneth C., primary

Published
2023
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234. Supplementary Figure 6 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo

Author

Mitsiades, Constantine S., primary, Ocio, Enrique M., primary, Pandiella, Atanasio, primary, Maiso, Patricia, primary, Gajate, Consuelo, primary, Garayoa, Mercedes, primary, Vilanova, David, primary, Montero, Juan Carlos, primary, Mitsiades, Nicholas, primary, McMullan, Ciaran J., primary, Munshi, Nikhil C., primary, Hideshima, Teru, primary, Chauhan, Dharminder, primary, Aviles, Pablo, primary, Otero, Gabriel, primary, Faircloth, Glynn, primary, Mateos, M. Victoria, primary, Richardson, Paul G., primary, Mollinedo, Faustino, primary, San-Miguel, Jesus F., primary, and Anderson, Kenneth C., primary

Published
2023
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235. Supplementary Figure 4 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo

Author

Mitsiades, Constantine S., primary, Ocio, Enrique M., primary, Pandiella, Atanasio, primary, Maiso, Patricia, primary, Gajate, Consuelo, primary, Garayoa, Mercedes, primary, Vilanova, David, primary, Montero, Juan Carlos, primary, Mitsiades, Nicholas, primary, McMullan, Ciaran J., primary, Munshi, Nikhil C., primary, Hideshima, Teru, primary, Chauhan, Dharminder, primary, Aviles, Pablo, primary, Otero, Gabriel, primary, Faircloth, Glynn, primary, Mateos, M. Victoria, primary, Richardson, Paul G., primary, Mollinedo, Faustino, primary, San-Miguel, Jesus F., primary, and Anderson, Kenneth C., primary

Published
2023
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236. Supplementary Figure 7 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo

Author

Mitsiades, Constantine S., primary, Ocio, Enrique M., primary, Pandiella, Atanasio, primary, Maiso, Patricia, primary, Gajate, Consuelo, primary, Garayoa, Mercedes, primary, Vilanova, David, primary, Montero, Juan Carlos, primary, Mitsiades, Nicholas, primary, McMullan, Ciaran J., primary, Munshi, Nikhil C., primary, Hideshima, Teru, primary, Chauhan, Dharminder, primary, Aviles, Pablo, primary, Otero, Gabriel, primary, Faircloth, Glynn, primary, Mateos, M. Victoria, primary, Richardson, Paul G., primary, Mollinedo, Faustino, primary, San-Miguel, Jesus F., primary, and Anderson, Kenneth C., primary

Published
2023
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237. Supplementary Figure 1 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo

Author

Mitsiades, Constantine S., primary, Ocio, Enrique M., primary, Pandiella, Atanasio, primary, Maiso, Patricia, primary, Gajate, Consuelo, primary, Garayoa, Mercedes, primary, Vilanova, David, primary, Montero, Juan Carlos, primary, Mitsiades, Nicholas, primary, McMullan, Ciaran J., primary, Munshi, Nikhil C., primary, Hideshima, Teru, primary, Chauhan, Dharminder, primary, Aviles, Pablo, primary, Otero, Gabriel, primary, Faircloth, Glynn, primary, Mateos, M. Victoria, primary, Richardson, Paul G., primary, Mollinedo, Faustino, primary, San-Miguel, Jesus F., primary, and Anderson, Kenneth C., primary

Published
2023
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238. Supplementary Table 2 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo

Author

Mitsiades, Constantine S., primary, Ocio, Enrique M., primary, Pandiella, Atanasio, primary, Maiso, Patricia, primary, Gajate, Consuelo, primary, Garayoa, Mercedes, primary, Vilanova, David, primary, Montero, Juan Carlos, primary, Mitsiades, Nicholas, primary, McMullan, Ciaran J., primary, Munshi, Nikhil C., primary, Hideshima, Teru, primary, Chauhan, Dharminder, primary, Aviles, Pablo, primary, Otero, Gabriel, primary, Faircloth, Glynn, primary, Mateos, M. Victoria, primary, Richardson, Paul G., primary, Mollinedo, Faustino, primary, San-Miguel, Jesus F., primary, and Anderson, Kenneth C., primary

Published
2023
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241. Chemical-proteomics Identify Peroxiredoxin-1 as an Actionable Target in Triple-negative Breast Cancer

Author

Spínola-Lasso, Elena, primary, Montero, Juan Carlos, additional, Jiménez-Monzón, Roberto, additional, Estévez, Francisco, additional, Quintana, José, additional, Guerra, Borja, additional, Elokely, Khaled M., additional, León, Francisco, additional, del Rosario, Henoc, additional, Fernández-Pérez, Leandro, additional, López, Manuel Rodríguez, additional, Díaz-Chico, Bonifacio Nicolás, additional, McNaughton-Smith, Grant, additional, Pandiella, Atanasio, additional, and Díaz-Chico, Juan Carlos, additional

Published
2023
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244. Data from Induction of B-Chronic Lymphocytic Leukemia Cell Apoptosis by Arsenic Trioxide Involves Suppression of the Phosphoinositide 3-Kinase/Akt Survival Pathway via c-jun-NH2 Terminal Kinase Activation and PTEN Upregulation

Author

Angeles García-Pardo, José A. García-Marco, María José Terol, Atanasio Pandiella, Mercedes Hernández del Cerro, Elizabeth Escobar-Díaz, and Javier Redondo-Muñoz

Abstract

Purpose: Arsenic trioxide (ATO) induces B-cell chronic lymphocytic leukemia (B-CLL) cell apoptosis in vitro. We sought to study the mechanism involved in this effect and whether ATO is suitable for combination therapies with protein kinase inhibitors.Experimental Design: B-CLL cells were isolated from the peripheral blood of 28 patients. Cell viability studies with ATO alone or in combination with kinase inhibitors were done by flow cytometry, Western blotting, and immunofluorescence analyses.Results: After 48 hours, 3 μmol/L ATO induced apoptosis (average 75%) in all B-CLL samples studied and with minimal effect on normal peripheral blood lymphocytes. Apoptosis entailed Akt and NF-κB inactivation, XIAP downregulation, and PTEN upregulation, thus implying inhibition of the phosphoinositide 3-kinase (PI3K) survival pathway. Indeed, the combination of ATO and PI3K inhibitors increased the apoptotic effect of either agent alone. ATO also induced c-jun-NH2 terminal kinase (JNK) activation, and this was crucial and required for subsequent apoptotic events, as inhibiting JNK activity by either gene silencing or specific inhibitors prevented Akt and NF-κB inactivation, caspase activation, and mitochondrial damage. Moreover, JNK activation was the earliest response to ATO, preceding and determining reactive oxygen species production.Conclusions: We identified the mechanism involved in ATO action on B-CLL cells and show that the combination of low doses of ATO and PI3K inhibitors efficiently induces B-CLL cell death. ATO may therefore constitute an efficient treatment for B-CLL, particularly in combined therapies. Clin Cancer Res; 16(17); 4382–91. ©2010 AACR.

Published
2023
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245. Supplementary Tables from Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer

Author

Joaquín Arribas, Cristina Saura, Javier Cortés, Wim H.A. Dokter, Fred A. Dijcks, Verónica Rodilla, Anna Esteve-Codina, Atanasio Pandiella, Lucía Gandullo-Sánchez, Santiago Escrivá-de-Romaní, Sandra Pérez-Ramos, Marta Escorihuela, Beatriz Morancho, Cristina Bernadó Morales, Enrique Javier Arenas, Marta Lalinde-Gutiérrez, Mercedes Nadal-Serrano, and Santiago Duro-Sánchez

Abstract

Supplementary Tables

Published
2023
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246. Data from Circulating DNA and Survival in Solid Tumors

Author

Eitan Amir, Atanasio Pandiella, Fernando Andrés-Pretel, Bostjan Seruga, Verónica Corrales-Sánchez, Gemma Serrano-Heras, María José Escribano, Francisco Vera-Badillo, Arnoud J. Templeton, Dolores C. García-Olmo, Laura Díez-González, and Alberto Ocaña

Abstract

Background: The ability to undertake molecular analysis to inform on prognosis and predictors of response to therapy is limited by accessibility of tissue. Measurement of total circulating free DNA (cfDNA) or circulating tumor DNA (ctDNA) in peripheral blood may allow easier access to tumor material and help to predict clinical outcomes.Methods: A systematic review of electronic databases identified publications exploring the association between cfDNA or ctDNA and overall survival (OS) in solid tumors. HRs for OS were extracted from multivariable analyses and included in a meta-analysis. Pooled HRs were computed and weighted using generic inverse variance and random-effect modeling. For studies not reporting multivariable analyses, univariable ORs were estimated from Kaplan–Meier curves for OS at 1 and 3 years.Results: Thirty-nine studies comprising 4,052 patients were included in the analysis. Detection of ctDNA was associated with a significantly worse OS in multivariable analyses [HR, 2.70; 95% confidence interval (CI), 2.02–3.61; P < 0.001). Similar results were observed in the univariable analyses at 3 and 1 year (OR, 4.83; 95% CI, 3.20–7.28; P < 0.001).There was also a statistically significant association between high total cfDNA and worse OS for studies reporting multivariable and univariate data at 3 years (HR, 1.91; 95% CI, 1.59–2.29; P < 0.001 and OR, 2.82; 95% CI, 1.93–4.13; P < 0.001, respectively).Conclusions: High levels of total cfDNA and presence of ctDNA are associated with worse survival in solid tumors.Impact: Circulating DNA is associated with worse outcome in solid tumors. Cancer Epidemiol Biomarkers Prev; 25(2); 399–406. ©2015 AACR.

Published
2023
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247. Supplementary Materials and Figure Legends from Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer

Author

Joaquín Arribas, Cristina Saura, Javier Cortés, Wim H.A. Dokter, Fred A. Dijcks, Verónica Rodilla, Anna Esteve-Codina, Atanasio Pandiella, Lucía Gandullo-Sánchez, Santiago Escrivá-de-Romaní, Sandra Pérez-Ramos, Marta Escorihuela, Beatriz Morancho, Cristina Bernadó Morales, Enrique Javier Arenas, Marta Lalinde-Gutiérrez, Mercedes Nadal-Serrano, and Santiago Duro-Sánchez

Abstract

Extended Materials and Methods and Supplementary figures with legends

Published
2023
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249. Supplementary Figure S2 from Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer

Author

Joaquín Arribas, Cristina Saura, Javier Cortés, Wim H.A. Dokter, Fred A. Dijcks, Verónica Rodilla, Anna Esteve-Codina, Atanasio Pandiella, Lucía Gandullo-Sánchez, Santiago Escrivá-de-Romaní, Sandra Pérez-Ramos, Marta Escorihuela, Beatriz Morancho, Cristina Bernadó Morales, Enrique Javier Arenas, Marta Lalinde-Gutiérrez, Mercedes Nadal-Serrano, and Santiago Duro-Sánchez

Abstract

Effect of doxorubicin and Cdk4/6i on cells expressing different levels of HER2.

Published
2023
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250. Supplementary Figure 6 from NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia

Author

Angel Hernández-Hernández, Consuelo del Cañizo, Fermín Sánchez-Guijo, Jesús F. San Miguel, Carmen Guerrero, Atanasio Pandiella, Marcial Llanillo, Marta Romo-González, Rodrigo Prieto-Bermejo, Guillermo López-Ruano, Sara Gutiérrez-Herrero, and Beatriz Sánchez-Sánchez

Abstract

PDF file - 44KB, Supplementary figure 6. Validation of the oligonucleotides pairs used to detect the expression of the different isoforms of NADPH oxidases.

Published
2023
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