Search

Your search keyword '"P. Riestra"' showing total 455 results
Start Over Author "P. Riestra"
455 results on '"P. Riestra"'

202. Switching to a Second Thiopurine in Adult and Elderly Patients With Inflammatory Bowel Disease: A Nationwide Study From the ENEIDA Registry.

Author

Calafat, Margalida, Mañosa, Míriam, Mesonero, Francisco, Guardiola, Jordi, Mínguez, Miguel, Nos, Pilar, Vera, Isabel, Taxonera, Carlos, Iglesias, Eva, Ricart, Elena, Gisbert, Javier P, Calvet, Xavier, García-López, Santiago, Monfort, David, Calle, José Lázaro Pérez, Riestra, Sabino, Gomollón, Fernando, Garcia-Planella, Esther, Bermejo, Fernando, and Hernández, Vicent

Abstract

Background and Aims Although commonly used in inflammatory bowel disease [IBD], thiopurines frequently cause intolerance, and switching to a second thiopurine has only been reported in some small series. Ours aims in this study were to evaluate the safety of switching to a second thiopurine in a large cohort, and to assess the impact of age on tolerance. Methods Adult IBD patients from the ENEIDA registry, who were switched to a second thiopurine due to adverse events [excluding malignancies and infections], were identified. At the beginning of thiopurine treatment, patients were divided by age into two groups: 18–50 and over 60 years of age. The rate and concordance of adverse events between the first and second thiopurines, treatment intolerance, and persistence with the second thiopurine were evaluated. Results A total of 1278 patients [13% over 60 years of age] were switched to a second thiopurine. At 12 months, the cumulative probability of switch intolerance was 43%, and persistence with treatment was 49%. Independent risk factors of switch intolerance were age over 60 years (odds ratio [OR] 1.49; 95% confidence interval [CI] 1.07–2.07; p = 0.017) , previous gastrointestinal toxicity [OR 1.4; 95% CI 1.11–1.78; p = 0.005], previous acute pancreatitis [OR 6.78; 95% CI 2.55–18.05; p <0.001], and exposure to the first thiopurine <6 months [OR 1.59; 95% CI 1.14–2.23; p = 0.007]. Conclusions In a large series in clinical practice, switching to a second thiopurine proved to be a valid strategy. Tight monitoring of elderly IBD patients switching to a second thiopurine because of adverse events is recommended. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

203. A Course in Project Evaluation in the Chemical Process Industries.

Author

Valle-Riestra, J. Frank

Abstract

Describes a course designed to expose neophytes to methodology used in chemical process industries to evaluate commercial feasibility of proposed projects. Previously acquired disciplines are integrated to facilitate process synthesis, gain appreciation of nature of industrial projects and industrial viewpoint in managing them, and to become adept at creating successful business ventures. (JM)

Published
1983

204. Effectiveness and Safety of the Switch from Remicade® to CT-P13 in Patients with Inflammatory Bowel Disease.

Author

Chaparro, M, Garre, A, Veloz, M F Guerra, Morón, J M Vázquez, Castro, M L De, Leo, E, Rodriguez, E, Carbajo, A Y, Riestra, S, Jiménez, I, Calvet, X, Bujanda, L, Rivero, M, Gomollón, F, Benítez, J M, Bermejo, F, Alcaide, N, Gutiérrez, A, Mañosa, M, and Iborra, M

Abstract

Background and Aims To evaluate the clinical outcomes in patients with IBD after switching from Remicade® to CT-P13 in comparison with patients who maintain Remicade®. Methods Patients under Remicade® who were in clinical remission with standard dosage at study entry were included. The 'switch cohort' [SC] comprised patients who made the switch from Remicade® to CT-P13, and the 'non-switch' cohort [NC] patients remained under Remicade®. Results A total of 476 patients were included: 199 [42%] in the SC and 277 [58%] in the NC. The median follow-up was 18 months in the SC and 23 months in the NC [ p < 0.01]. Twenty-four out of 277 patients relapsed in the NC; the incidence of relapse was 5% per patient-year. The cumulative incidence of relapse was 2% at 6 months and 10% at 24 months in this group. Thirty-eight out of 199 patients relapsed in the SC; the incidence rate of relapse was 14% per patient-year. The cumulative incidence of relapse was 5% at 6 months and 28% at 24 months. In the multivariate analysis, the switch to CT-P13 was associated with a higher risk of relapse (HR = 3.5, 95% confidence interval [CI] = 2–6). Thirteen percent of patients had adverse events in the NC, compared with 6% in the SC [ p < 0.05]. Conclusions Switching from Remicade® to CT-P13 might be associated with a higher risk of clinical relapse, although this fact was not supported in our study by an increase in objective markers of inflammation. The nocebo effect might have influenced this result. Switching from Remicade® to CT-P13 was safe. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

205. Global multi-stakeholder endorsement of the MAFLD definition

Author

Méndez-Sánchez, Nahum, Bugianesi, Elisabetta, Gish, Robert G, Lammert, Frank, Tilg, Herbert, Nguyen, Mindie H, Sarin, Shiv K, Fabrellas, Núria, Zelber-Sagi, Shira, Fan, Jian-Gao, Shiha, Gamal, Targher, Giovanni, Zheng, Ming-Hua, Chan, Wah-Kheong, Vinker, Shlomo, Kawaguchi, Takumi, Castera, Laurent, Yilmaz, Yusuf, Korenjak, Marko, Spearman, C Wendy, Ungan, Mehmet, Palmer, Melissa, El-Shabrawi, Mortada, Gruss, Hans-Juergen, Dufour, Jean-François, Dhawan, Anil, Wedemeyer, Heiner, George, Jacob, Valenti, Luca, Fouad, Yasser, Romero‐Gomez, Manuel, Eslam, Mohammed, Abate, Maria Lorena, Abbas, Bahaa, Abbassy, Ahmed Amr, Abd El Ghany, Waleed, Abd Elkhalek, Amira, Abd ElMajeed, Emad, Abdalgaber, Mohammad, AbdAllah, Mohamed, Abdallah, Marwa, Abdallah, Nourhan, Abdelaleem, Shereen, Abdelghani, Yasser, Abdelghany, Wael, Abdelhalim, Safaa Mohamed, Abdelhamid, Wafaa, Abdelhamid, Nehal, Abdelkader, Nadia A., Abdelkreem, Elsayed, Abdelmohsen, Aly Mohamed, Abdelrahman, Awny Ali, Abd-elsalam, Sherief M, Abdeltawab, Doaa, Abduh, Abdulbaset, Abdulhakam, Nada, Abdulla, Maheeba, Abedpoor, Navid, Abenavoli, Ludovico, Åberg, Fredrik, Ablack, Omala, Abo elftouh, Mostafa, Abo-Amer, Yousry Esam-Eldin, Aboubkr, Ashraf, Aboud, Alaa, Abouelnaga, Amr M., Aboufarrag, Galal A., Aboutaleb, Ashraf, Abundis, Leticia, Adalı, Gupse, Adames, Enrique, Adams, Leon, Adda, Danjuma, Adel, Noor, Adel, Nada, Adel Sayed, Muhammad, Afaa, Taiba Jibril, Afredj, Nawal, Aghayeva, Gulnara, Aghemo, Alessio, Aguilar-Salinas, Carlos A., Ahlenstiel, Golo, Ahmady, Walid, Ahmed, Wafaa, Ahmed, Amira, Ahmed, Samah Nasser, Ahmed, Heba Mostafa, Ahmed, Rasha, Aigner, Elmar, Akarsu, Mesut, Akroush, Maisam, Akyuz, Umit, Al Mahtab, Mamun, Al Qadiri, Tahani, Al Rawahi, Yusriya, AL rubaee, Razzaq, Al Saffar, Muna, Alam, Shahinul, Al-Ani, Zaid, Albillos, Agustín, Alboraie, Mohamed, Al-Busafi, Said, Al-Emam, Mohamed, Alharthi, Jawaher, Ali, Kareem, Ali, Basma Abdelmoez, Ali, Mohammad, Ali, Raja Affendi Raja, Alisi, Anna, AL-Khafaji, Ali Raad, Alkhatry, Maryam, Aller, Rocio, Almansoury, Yahya, Al-Naamani, Khalid, Alnakeeb, Alaa, Alonso, Anna, Alqahtani, Saleh A., Alrabadi, Leina, Alswat, Khalid, Altaher, Mahir, Altamimi, Turki, Altamirano, Jose, Alvares-da-Silva, Mario R., Aly, Elsragy Adel M., Alzahaby, Amgad, Alzamzamy, Ahmed, Amano, Keisuke, Amer, Maysa A., Amin, Mona A., Amin, Sayed A., Amir, Ashraf A., Ampuero, Javier, Anas, Noha, Andreone, Pietro, Andriamandimby, Soa Fy, Anees, Mahmoud, Angela, Peltec, Antonios, Manal, Arafat, Wael, Araya, Jose Moreno, Armendariz-Borunda, Juan, Armstrong, Matthew J., Ashktorab, Hassan, Aspichueta, Patricia, Assal, Fathia, Atef, Mira, Attia, Dina, Atwa, Hoda, Awad, Reham, Awad, Mohyeldeen Abd Elaziz, Awny, Sally, Awolowo, Obafemi, Awuku, Yaw Asante, Ayada, Ibrahim, Aye, Than Than, Ayman, Sherif, Ayman, Hedy, Ayoub, Hesham, Azmy, Hosny M., Babaran, Romiro P., Badreldin, Omneya, Badry, Ahmed, Bahçecioğlu, İbrahim Halil, Bahour, Amira, Bai, Jiajia, Balaban, Yasemin, Balasubramanyam, Muthuswamy, Bamakhrama, Khaled, Banales, Jesus M, Bangaru, Babu, Bao, Jianfeng, Barahona, Jorge Suazo, Barakat, Salma, Barbalho, Sandra Maria, Barbra, Bikwa, Barranco, Beatriz, Barrera, Francisco, Baumann, Ulrich, Bazeed, Shamardan, Bech, Eva, Benayad, Aourarh, Benesic, Andreas, Bernstein, David, Bessone, Fernando, Birney, Susie, Bisseye, Cyrille, Blake, Martin, Bobat, Bilal, Bonfrate, Leonilde, Bordin, Dmitry S, Bosques-Padilla, Francisco, Boursier, Jerome, Boushab, Boushab Mohamed, Bowen, David, Bravo, Patricia Medina, Brennan, Paul N, Bright, Bisi, Broekaert, Ilse, Buque, Xabier, Burgos-Santamaría, Diego, Burman, Julio, Busetto, Luca, Byrne, Chris D., Cabral-Prodigalidad, Patricia Anne I., Cabrera-Alvarez, Guillermo, Cai, Wei, Cainelli, Francesca, Caliskan, Ali Riza, Canbay, Ali, Cano-Contreras, Ana, Cao, Hai-Xia, Cao, Zhujun, Carrion, Andres, Carubbi, Francesca, Casanovas, Teresa, Castellanos Fernández, Marlen Ivón, Chai, Jin, Chan, Siew Pheng, Charatcharoenwitthaya, Phunchai, Chavez-Tapia, Norberto, Chayama, Kazuaki, Chen, Jinjun, Chen, Lin, Chen, Zhong-Wei, Chen, Huiting, Chen, Sui-Dan, Chen, Qiang, Chen, Yaxi, Chen, Gang, Chen, En-Quang, Chen, Fei, Chen, Fei, Chen, Pei-Jer, Cheng, Robert, Cheng, Wendy, Chieh, Jack Tan Wei, Chokr, Imad, Cholongitas, Evangelos, Choudhury, Ashok, Chowdhury, Abhijit, Chukwudike, Evaristus Sunday, Ciardullo, Stefano, Clayton, Michelle, Clement, Karine, Cloa, Marie Michelle, Coccia, Cecilia, Collazos, Cristina, Colombo, Massimo, Cosar, Arif Mansur, Cotrim, Helma Pinchemel, Couillerot, Joris, Coulibaly, Alioune, Crespo, Gonzalo, Crespo, Javier, Cruells, Maria, Cua, Ian Homer Y., Dabbous, Hesham K., Dalekos, George N, D'Alia, Patricia, Dan, Li, Dao, Viet Hang, Darwish, Mostafa, Datz, Christian, Davalos-Moscol, Milagros B, Dawoud, Heba, de Careaga, Blanca Olaechea, de Knegt, Robert, de Ledinghen, Victor, de Silva, Janaka, Debzi, Nabil, Decraecker, Marie, Del Pozo, Elvira, Delgado, Teresa C, Delgado-Blanco, Manuel, Dembiński, Łukasz, Depina, Adilson, Derbala, Moutaz, Desalegn, Hailemichael, Desbois-Mouthon, Christèle, Desoky, Mahmoud, Dev, Anouk, Di Ciaula, Agostino, Diago, Moisés, Diallo, Ibrahima, Díaz, Luis Antonio, Dirchwolf, Melisa, Dongiovanni, Paola, Dorofeyev, Andrriy, Dou, Xiaoguang, Douglas, Mark W., Doulberis, Michael, Dovia, Cecil K., Doyle, Adam, Dragojević, Ivana, Drenth, Joost PH, Duan, Xuefei, Dulskas, Audrius, Dumitrascu, Dan L, Duncan, Oliver, Dusabejambo, Vincent, Dwawhi, Rev. Shem N.A., Eiketsu, Sho, El Amrousy, Doaa, El Deeb, Ahmed, El Deriny, Ghada, El Din, Hesham Salah, El Kamshishy, Salwa, El Kassas, Mohamed, El Raziky, Maissa, Elagamy, Osama A, Elakel, Wafaa, Elalfy, Dina, Elaraby, Hanaa, ElAwady, Heba, Elbadawy, Reda, Eldash, Hanaa Hassan, Eldefrawy, Manal S., Elecharri, Carol Lezama, Elfaramawy, Amel, Elfatih, Mohammed, Elfiky, Mahmoud, Elgamsy, Mohamed, Elgendy, Mohamed, El-Guindi, Mohamed A., Elhussieny, Nagi, Eliwa, Ahmed Maher, Elkabbany, Zeineb, El-Khayat, Hesham, El-Koofy, Nehal M., Elmetwalli, Alaa, Elrabat, Amr, El-Raey, Fathiya, Elrashdy, Fatma, Elsahhar, Medhat, Elsaid, Esraa M., Elsayed, Shimaa, Elsayed, Hany, Elsayed, Aly, Elsayed, Amr M., Elsayed, Hamdy, El-Serafy, Magdy, Elsharkawy, Ahmed M., Elsheemy, Reem Yehia, Elshemy, Eman Elsayed, Elsherbini, Sara, Eltoukhy, Naglaa, Elwakil, Reda, Emad, Ola, Emad, Shaimaa, Embabi, Mohamed, Ergenç, Ilkay, Ermolova, Tatiana, Esmat, Gamal, Esmat, Doaa M., Estupiñan, Enrique Carrera, Ettair, Said, Eugen, Tcaciuc, Ezz-Eldin, Mohammed, Falcón, Lidia Patricia Valdivieso, Fan, Yu-Chen, Fandari, Samah, Farag, Mahmoud, Farahat, Taghreed Mohamed, Fares, Eman M., Fares, Michael, Fassio, Eduardo, Fathy, Hayam, Fathy, Dina, Fathy, Wael, Fayed, Soheir, Feng, Dan, Feng, Gong, Fernández-Bermejo, Miguel, Ferreira, Cristina Targa, Ferrer, Javier Díaz, Forbes, Alastair, Fouad, Rabab, Fouad, Hanan M., Frisch, Tove, Fujii, Hideki, Fukunaga, Shuhei, Fukunishi, Shinya, Fulya, Hacer, Furuhashi, Masato, Gaber, Yasmine, Galang, Augusto Jose G., Gallardo, Jacqueline Cordova, Galloso, Rocío, Gamal, Mahmoud, Gamal, Reham, Gamal, Hadeel, Gan, Jian, Ganbold, Anar, Gao, Xin, Garas, George, Garba, Tony, García-Cortes, Miren, García-Monzón, Carmelo, García-Samaniego, Javier, Gastaldelli, Amalia, Gatica, Manuel, Gatley, Elizabeth, Gegeshidze, Tamar, Geng, Bin, Ghazinyan, Hasmik, Ghoneem, Salma, Giacomelli, Luca, Giannelli, Gianluigi, Giannini, Edoardo G., Giefer, Matthew, Ginès, Pere, Girala, Marcos, Giraudi, Pablo J, Goh, George Boon-Bee, Gomaa, Ahmed Ali, Gong, Benbingdi, Gonzales, Dina Hilda C., Gonzalez, Humberto C., Gonzalez-Huezo, Maria Saraí, Graupera, Isabel, Grgurevic, Ivica, Grønbæk, Henning, Gu, Xuelian, Guan, Lin, Gueye, Ibrahima, Guingané, Alice Nanelin, Gul, Ozen Oz, Gul, Cuma Bulent, Guo, Qing, Gupta, Pramendra Prasad, Gurakar, Ahmet, Gutierrez, Juan Carlos Restrepo, Habib, Ghada, Hafez, Azaa, Hagman, Emilia, Halawa, Eman, Hamdy, Osama, Hamed, Abd Elkhalek, Hamed, Dina H., Hamid, Saeed, Hamoudi, Waseem, Han, Yu, Haridy, James, Haridy, Hanan, Harris, David C H Harris, Hart, Michael, Hasan, Fuad, Hashim, Almoutaz, Hassan, Israa, Hassan, Ayman, Hassan, Essam Ali, Hassan, Adel Ahmed, Hassan, Magda Shehata, Hassanin, Fetouh, Hassnine, Alshymaa, Haukeland, John Willy, Hawal, Amr Ismael M., He, Jinfan, He, Qiong, He, Yong, He, Fang-Ping, Hegazy, Mona, Hegazy, Adham, Henegil, Osama, Hernández, Nelia, Hernández-Guerra, Manuel, Higuera-de-la-Tijera, Fatima, Hindy, Ibrahim, Hirota, Keisuke, Ho, Lee Chi, Hodge, Alexander, Hosny, Mohamed, Hou, Xin, Huang, Jiao-Feng, Huang, Yan, Huang, Zhifeng, Huang, Yuan, Huang, Ang, Huang, Yuan, Huang, Xiao-Ping, Hui-ping, Sheng, Hunyady, Bela, Hussein, Mennatallah A., Hussein, Osama, Hussien, Shahinaz Mahmoud, Ibáñez-Samaniego, Luis, Ibdah, Jamal, Ibrahim, Luqman, Ibrahim, Miada, Ibrahim, Ibrahim, Icaza-Chávez, Maria E., Idelbi, Sahar, Idilman, Ramazan Idilman, Ikeda, Mayumi, Indolfi, Giuseppe, Invernizzi, Federica, Irshad, Iram, Isa, Hasan Mohamed Ali, Iskandar, Natacha Jreige, Ismaiel, Abdulrahman, Ismail, Mariam, Ismail, Zulkifli, Ismail, Faisal, Iwamoto, Hideki, Jack, Kathryn, Jacob, Rachael, Jafarov, Fuad, Jafri, Wasim, Jahshan, Helen, Jalal, Prasun K, Jancoriene, Ligita, Janicko, Martin, Jayasena, Hiruni, Jefferies, Meryem, Jha, Vivekanand, Ji, Fanpu, Ji, Yaqiu, Jia, Jidong, Jiang, Changtao, Jiang, Ni, Jiang, Zong-zhe, Jin, Xing, Jin, Yi, Jing, Xu, Jingyu, Qian, Jinjolava, Maia, Jong, FX Himawan Haryanto, Jucov, Alina, Julius, Ibecheole, Kaddah, Mona, Kamada, Yoshihiro, kamal, Abobakr, Kamal, Enas Mohamed, Kamel, Ashraf Sayed, Kao, Jia-Horng, Karin, Maja, Karlas, Thomas, Kashwaa, Mohammad, Katsidzira, Leolin, Kaya, Eda, Kayasseh, M.Azzam, Keenan, Bernadette, Keklikkiran, Caglayan, Keml, William, Khalaf, Deia K., Khalefa, Rofida, Khamis, Sherin, Khater, Doaa, khattab, Hamed, Khavkin, Anatoly, Khlynova, Olga, Khmis, Nabil, Kobyliak, Nazarii, Koffas, Apostolos, Koike, Kazuhiko, Kok, Kenneth Y.Y., Koller, Tomas, Komas, Narcisse Patrice, Korochanskaya, Nataliya V., Koulla, Yannoula, Koya, Shunji, Kraft, Colleen, Kraja, Bledar, Krawczyk, Marcin, Kuchay, Mohammad Shafi, Kulkarni, Anand V, Kumar, Ashish, Kumar, Manoj, Lakoh, Sulaiman, Lam, Philip, Lan, Ling, Lange, Naomi F., Lankarani, Kamran Bagheri, Lanthier, Nicolas, Lapshyna, Kateryna, Lashen, Sameh A., Laure, Konang Nguieguia Justine, Lazebnik, Leonid, Lebrec, Didier, Lee, Samuel S., Lee, Way Seah, Lee, Yeong Yeh, Leeming, Diana Julie, Leite, Nathalie Carvalho, Leon, Roberto, Lesmana, Cosmas Rinaldi Adithya, Li, Junfeng, Li, Qiong, Li, Jun, Li, Yang-Yang, Li, Yufang, Li, Lei, Li, Min, li, Yiling, Liang, Huiqing, Lijuan, Tang, Lim, Seng Gee, Lim, Lee-Ling, Lin, Shumei, Lin, Han-Chieh, Lin, Rita, Lithy, Rania, Liu, Yaru, Liu, Yuanyuan, Liu, Xin, Liu, Wen-Yue, Liu, Shourong, Liu, Ken, Liu, Tian, Lonardo, Amedeo, López, Mariana Bravo, López-Benages, Eva, Lopez-Jaramillo, Patricio, Lu, Huimin, Lu, Lun Gen, Lu, Yan, Lubel, John, Lui, Rashid, Lupasco, Iulianna, Luzina, Elena, Lv, Xiao-Hui, Lynch, Kate, Ma, Hong-Lei, Machado, Mariana Verdelho, Maduka, Nonso, Madzharova, Katerina, Magdaong, Russellini, Mahadeva, Sanjiv, Mahfouz, Amel, Mahmood, Nik Ritza Kosai Nik, Mahmoud, Eman, Mahrous, Mohamed, Maiwall, Rakhi, Majeed, Ammar, Majumdar, Avik, Mak, Loey, Maklouf, Madiha M, Malekzadeh, Reza, Mandato, Claudia, Mangia, Alessandra, Mann, Jake, Mansour, Hala Hussien, Mansouri, Abdellah, Mantovani, Alessandro, Mao, Jun qian, Maramag, Flor, Marchesini, Giulio, Marcus, Claude, Marinho, Rui António Rocha Tato, Martinez-Chantar, Maria L, Martins, Antonieta A. Soares, Marwan, Rana, Mason, Karen Frances, Masoud, Ghadeer, Massoud, Mohamed Naguib, Matamoros, Maria Amalia, Mateos, Rosa Martín, Mawed, Asmaa, Mbanya, Jean Claude, Mbendi, Charles, McColaugh, Lone, McLeod, Duncan, Medina, Juan Francisco Rivera, Megahed, Ahmed, Mehrez, Mai, Memon, Iqbal, Merat, Shahin, Mercado, Randy, Mesbah, Ahmed, Meskini, Taoufik, Metwally, Mayada, Metwaly, Rasha, Miao, Lei, Micah, Eileen, Miele, Luca, Milivojevic, Vladimir, Milovanovic, Tamara, Mina, Yvonne L., Mishkovik, Milan, Mishriki, Amal, Mitchell, Tim, Mohamed, Alshaimaa, Mohamed, Mona, Mohamed, Sofain, Mohammed, Shady, Mohammed, Ahmed, Mohan, Viswanathan, Mohie, Sara, Mokhtar, Aalaa, Moniem, Reham, Montilla, Mabel Segura, Morales, Jose Antonio Orozco, Morata, María María Sánchez, Moreno-Planas, Jose Maria, Morise, Silvia, Mosaad, Sherif, Moselhy, Mohamed, Mostafa, Alaa Mohamed, Mostafa, Ebraheem, Mouane, Nezha, Mousa, Nasser, Moustafa, Hamdy Mahfouz, Msherif, Abeer, Muller, Kate, Munoz, Christopher, Muñoz-Urribarri, Ana Beatriz, Murillo, Omar Alfaro, Mustapha, Feisul Idzwan, Muzurović, Emir, Nabil, Yehia, Nafady, Shaymaa, Nagamatsu, Ayu, Nakajima, Atsushi, Nakano, Dan, Nan, Yuemin, Nascimbeni, Fabio, Naseef, Mirella S., Nashat, Nagwa, Natalia, Taran, Negro, Francesco, Nersesov, Alexander V., Neuman, Manuela, Ng'wanasayi, Masolwa, Ni, Yan, Nicoll, Amanda, Niizeki, Takashi, Nikolova, Dafina, Ningning, Wang, Niriella, Madunil, Nogoibaeva, K.A, Nordien, Rozeena, O Sullivan, Catherine, O'Beirne, James, Obekpa, Solomon, Ocama, Ponsiano, Ochwoto, Missiani, Ogolodom, Michael Promise, Ojo, Olusegun, Okrostsvaridze, Nana, Oliveira, Claudia P., Omaña, Raul Contreras, Omar, Omneya M., Omar, Hanaa, Omar, Mabroka, Omran, Salma, Omran, Reham, Osman, Marian Muse, Owise, Nevin, Owusu-Ansah, Theobald, Padilla- Machaca, P. Martín, Palle, Sirish, Pan, Ziyan, Pan, Xiao-Yan, Pan, Qiuwei, Papaefthymiou, Apostolis, Paquissi, Feliciano Chanana, Par, Gabriella, Parkash, Arit, Payawal, Diana, Peltekian, Kevork M., Peng, Xuebin, Peng, Liang, Peng, Ying, Pengoria, Rahul, Perez, Martina, Pérez, José Luis, Pérez, Norma Marlene, Persico, Marcello, Pessoa, Mário Guimarães, Petta, Salvatore, Philip, Mathew, Plaz Torres, Maria Corina, Polavarapu, Naveen, Poniachik, Jaime, Portincasa, Piero, Pu, Chunwen, Pürnak, Tuğrul, Purwanto, Edhie, Qi, Xiaolong, Qi, Xingshun, Qian, Zibing, Qiang, Zhao, Qiao, Zengpei, Qiao, Liang, Queiroz, Alberto, Rabiee, Atoosa, Radwan, Manal, Rahetilahy, Alain Marcel, Ramadan, Yasmin, Ramadan, Dina, Ramli, Anis Safura, Ramm, Grant A., Ran, Ao, Rankovic, Ivan, RAO, Huiying, Raouf, Sara, Ray, Sayantan, Reau, Nancy, Refaat, Ahmed, Reiberger, Thomas, Remes-Troche, Jose M, Reyes, Eira Cerda, Richardson, Ben, Ridruejo, Ezequiel, Riestra Jimenez, Sergio, Rizk, Ibrahim, Roberts, Stuart, Roblero, Juan Pablo, Robles, Jorge Alberto Prado, Rockey, Don, Rodríguez, Manuel, Rodríguez Hernández, Heriberto, Román, Eva, Romeiro, Fernando Gomes, Romeo, Stefano, Rosales-Zabal, Jose Miguel, Roshdi, Georgina R., Rosso, Natalia, Ruf, Andres, Ruiz, Patricia Cordero, Runes, Nelia R., Ruzzenente, Andrea, Ryan, Marno, Saad, Ahmed, Sabbagh, Eman BE, Sabbah, Meriam, Saber, Shimaa, Sabrey, Reham, Sabry, Ramy, Saeed, Maysaa Abdallah, Said, Dina, Said, Ebada M, Sakr, Mohammad Amin, Salah, Yara, Salama, Rabab Maamoun, Salama, Asmaa, Saleh, Hussein, Saleh, Ahmed, Salem, Ahmed, Salem, Ahmed Thabet, Salifou, Alkassoum, Salih, Aso Faeq, Salman, Abdallah, Samouda, Hanen, Sanai, Faisal, Sánchez-Ávila, Juan Francisco, Sanker, Lakshumanan, Sano, Tomoya, Sanz, Miquel, Saparbu, Tobokalova, Sawhney, Rohit, Sayed, Fatma, Sayed, Sayed A., Sayed, Ashraf Othman, Sayed, Manar, Sebastiani, Giada, Secadas, Laura, Sediqi, Khawaja Qamaruddin, Seif, Sameh, Semida, Nady, Şenateş, Ebubekir, Serban, Elena Daniela, Serfaty, Lawrence, Seto, Wai-Kay, Sghaier, Ikram, Sha, Min, Shabaan, Hamada M., Shalaby, Lobna, Shaltout, Inass, Sharara, Ala I., Sharma, Vishal, Shawa, Isaac Thom, Shawkat, Ahmed, Shawky, Nehal, Shehata, Osama, Sheils, Sinead, Shewaye, Abate Bane, Shi, Guojun, Shi, Junping, Shimose, Shigeo, Shirono, Tomotake, Shou, Lan, Shrestha, Ananta, Shui, Guanghou, Sievert, William, Sigurdardottir, Solveig, Sira, Mostafa Mohamed, Siradj, Riyadh, Sison, Cecilia, Smyth, Linda, Soliman, Reham, Sollano, Jose D, Sombie, Roger, Sonderup, Mark, Sood, Siddharth, Soriano, German, Stedman, Catherine A M, Stefanyuk, Oksana, Štimac, Davor, Strasser, Simone, Strnad, Pavel, Stuart, Katherine, Su, Wen, Su, Minghua, Sumida, Yoshio, Sumie, Shuji, Sun, Dan-Qin, Sun, Jing, Suzuki, Hiroyuki, Svegliati-Baroni, Gianluca, Swar, Mohamed Osman, TAHARBOUCHT, S., Taher, Zenab, Takamura, Saori, Tan, Lin, Tan, Soek-Siam, Tanwandee, Tawesak, Tarek, Sara, Tatiana, Ghelimici, Tavaglione, Federica, Tecson, Gina Y., Tee, Hoi-Poh, Teschke, Rolf, Tharwat, Mostafa, Thong, Vo Duy, Thursz, Mark, Tine, Tulari, Tiribelli, Claudio, Tolmane, Ieva, Tong, Jing, Tongo, Marco, Torkie, Mamdouh, Torre, Aldo, Torres, Esther A, Trajkovska, Meri, Treeprasertsuk, Sombat, Tsutsumi, Tsubasa, Tu, Thomas, Tur, Josep A., Turan, Dilara, Turcan, Svetlana, Turkina, Svetlana, Tutar, Engin, Tzeuton, Christian, Ugiagbe, Rose, Uygun, Ahmet, Vacca, Michele, Vajro, Pietro, Van der Poorten, David, Van Kleef, Laurens A., Vashakidze, Eliza, Velazquez, Carlos Moctezuma, Velazquez, Mirtha Infante, Vento, Sandro, Verhoeven, Veronique, Vespasiani-Gentilucci, Umberto, Vethakkan, Shireene Ratna, Vilaseca, Josep, Vítek, Libor, Volkanovska, Ance, Wallace, Michael, Wan, Wang, Wang, Yan, Wang, Ying, Wang, Xiaolin, Wang, Xuemei, Wang, Chengyan, Wang, Chunjiong, Wang, Mingjie, Wangchuk, Pelden, Weltman, Martin, White, MaryFrances, Wiegand, Johannes, Wifi, Mohamed-Naguib, Wigg, Alan, Wilhelmi, Markus, William, Remon, Wittenburg, Henning, Wu, Shengjie, Wubeneh, Abdu Mohammed, Xia, Hongping, Xiao, Jian, Xiao, Xiao, Xiaofeng, Wang, Xiong, Wanyuan, Xu, Liang, Xu, Jie, Xu, Weiguo, Xu, Jing-Hang, Xu, Keshu, Xu, Yumin, Xu, Shi-Hao, Xu, Meng, Xu, Aimin, Xu, Chengfu, Yan, Hongmei, Yang, Jingyi, Yang, Rui-Xu, Yang, Yating, Yang, Qinhe, Yang, Naibin, Yao, Jia, Yara, Justine, Yaraş, Serkan, Yılmaz, Nimet, Younes, Ramy, younes, Huda, Young, Sona, Youssef, Farah, Yu, Yanyan, Yu, Ming-Lung, Yuan, Jing, Yue, Zhang, Yuen, Man-Fung, Yun, Wang, Yurukova, Nonka, Zakaria, Serag, Zaky, Samy, Zaldastanishvili, Maia, Zapata, Rodrigo, Zare, Nazanin, Zerem, Enver, Zeriban, Nema, Zeshuai, Xu, Zhang, Huijie, Zhang, Xuemei, Zhang, Yupei, Zhang, Wen-Hua, Zhang, Xuchen, Zhang, Yon-ping, Zhang, Yuexin, Zhang, Zhan-qing, Zhao, Jingmin, Zhao, Rong-Rong, Zhao, Hongwei, Zheng, Chao, Zheng, Yijie, Zheng, Ruidan, Zheng, Tian-Lei, Zheng, Kenneth, Zhou, Xi Qiao, Zhou, Yongjian, Zhou, Yu-Jie, Zhou, Hong, Zhou, Ling, Zhou, Yongning, Zhu, Long dong, Zhu, Yong Fen, Zhu, Yueyong, Zhu, Pei-Wu, Ziada, Ebtesam, Ziring, David, Ziyi, Li, Zou, Shanshan, Zou, Zhengsheng, Zou, Huaibin, and Zuart Ruiz, Roberto

Published
2022
Full Text
View/download PDF

206. Pulmonary artery pseudoaneurysm arising from primary lung neoplasm: A proposed mechanism.

Author

Riestra Guiance, Irene, Meade, Charles, McCambridge, Amanda, Bendel, Emily, and Kern, Ryan

Abstract

Pulmonary artery pseudoaneurysms (PAPs) are rare and life-threatening occurrences. We present a 57-year-old male patient with squamous cell lung cancer, who presented with hemoptysis. Bronchoscopy did not reveal ongoing bleeding. Imaging showed a left lower lobe tumor, a cavitary lesion communicating with the bronchus, and a pulmonary artery pseudoaneurysm. Successful embolization of the originating segmental branch of the pulmonary artery was performed. The pathogenesis of PAPs associated with primary lung malignancies remains poorly understood. We propose a four-step mechanism involving primary tumor expansion, central cavitary necrosis, direct arterial invasion, inflammatory response, vessel wall damage, pseudoaneurysm formation, and subsequent filling of the former cavitary lesion. This case emphasizes the importance of considering PAPs in primary lung malignancies, particularly in male patients with squamous cell pathology. Understanding the proposed pathogenic mechanism could lead to early detection, prompt intervention, and improved outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

207. Recomendaciones del Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU) sobre el cribado y tratamiento de la infección tuberculosa en pacientes con enfermedad inflamatoria intestinal

Author

Riestra, Sabino, Taxonera, Carlos, Zabana, Yamile, Carpio, Daniel, Beltrán, Belén, Mañosa, Míriam, Gutiérrez, Ana, and Barreiro-de Acosta, Manuel

Abstract

La evidencia de que el seguimiento de las recomendaciones sobre el cribado y tratamiento de la infección tuberculosa no evita totalmente la aparición de tuberculosis en pacientes con enfermedad inflamatoria intestinal, y el uso reciente de nuevos fármacos biológicos y de nuevos inmunomoduladores, ha llevado al Grupo Español de Trabajo en Enfermedad de Crohn y en Colitis Ulcerosa a actualizar sus recomendaciones para la prevención de la tuberculosis en los pacientes con enfermedad inflamatoria intestinal. Se revisan los métodos de diagnóstico de la infección tuberculosa latente, los distintos escenarios en los que se va a realizar el cribado, las estrategias para disminuir el riesgo de tuberculosis una vez iniciado el tratamiento biológico, las pautas de quimioprofilaxis de la infección tuberculosa latente y el manejo de la tuberculosis activa durante el tratamiento biológico. Finalmente, se resumen las recomendaciones en el texto y en un algoritmo.

Published
2021
Full Text
View/download PDF

208. Las responsabilidades derivadas del uso de las tecnologías de la información y comunicación en el ejercicio de las profesiones sanitarias

Author

Muñoz Fernández, Laura, Díaz García, Elena, and Gallego Riestra, Sergio

Abstract

La evolución de las tecnologías de la información y comunicación (en adelante TIC) en el ámbito sanitario ha dado lugar al fenómeno actual de la eHealth o eSalud, términos equivalentes al concepto de ciberespacio, pero referido exclusivamente a la salud. Fruto de la aparición de la web 2.0 se puede afirmar que nos encontramos ante un fenómeno mucho mayor que lo que sería el mero uso de tecnologías: estamos ante un verdadero cambio social dando lugar a la denominada Salud 2.0.

Published
2020
Full Text
View/download PDF

209. Efficacy of Long-lasting Insecticidal Nets With Declining Physical and Chemical Integrity on Aedes aegypti(Diptera: Culicidae)

Author

Herrera-Bojórquez, Josué, Trujillo-Peña, Emilio, Vadillo-Sánchez, José, Riestra-Morales, Martin, Che-Mendoza, Azael, Delfín-González, Hugo, Pavía-Ruz, Norma, Arredondo-Jimenez, Juan, Santamaría, Erika, Flores-Suárez, Adriana E, Vazquez-Prokopec, Gonzalo, and Manrique-Saide, Pablo

Abstract

Fitting long-lasting insecticidal nets (LLIN) as screens on doors/windows has a significant impact on indoor-adult Aedes aegypti(L.), with entomological reductions measured in a previous study being significant for up to 2 yr post-installation, even in the presence of pyrethroid-resistant Aedespopulations. To better understand the mode of LLIN protection, bioassays were performed to evaluate the effects of field deployment (0, 6, and 12 mo) and damage type (none, central, lateral, and multiple) on LLIN efficacy. Contact bioassays confirmed that LLIN residual activity (median knockdown time, in minutes, or MKDT) decreased significantly over time: 6.95 (95% confidence interval [CI]: 5.32–8.58) to 9.24 (95% CI: 8.69–9.79) MKDT at 0- and 12-mo age, respectively, using a pyrethroid-susceptible Aedesstrain. Tunnel tests (exposing human forearm for 40 min as attractant) showed that deployment time affected negatively Aedespassage inhibition from 54.9% (95% CI: 43.5–66.2) at 0 mo to 35.7% (95% CI: 16.3–55.1) at 12 mo and blood-feeding inhibition from 65.2% (95% CI: 54.2–76.2) to 48.9% (95% CI: 26.4–71.3), respectively; both the passage/blood-feeding inhibition increased by a factor of 1.8–2.9 on LLINs with multiple and central damages compared with nets with lateral damage. Mosquito mortality was 74.6% (95% CI: 65.3–83.9) at 0 mo, 72.3% (95% CI: 64.1–80.5) at 6 mo, and 59% (95% CI: 46.7–71.3) at 12 mo. Despite the LLIN physical integrity could be compromised over time, we demonstrate that the remaining chemical effect after field conditions would still contribute to killing/repelling mosquitoes.

Published
2020
Full Text
View/download PDF

210. High rates of tuberculin skin test positivity due to methotrexate therapy: False positive results?

Author

Arias-Guillén, Miguel, Sánchez Menéndez, Marta M., Alperi, Mercedes, Riestra, Sabino, González Budiño, María Teresa, García-Clemente, Marta María, Martínez-González, Susana, Enríquez, Ana Isabel, Alonso-Arias, Rebeca, Palacios Gutiérrez, Juan José, Santibáñez, Miguel, Coto-Segura, Pablo, Camblor, Pablo Martínez, García-Alfonso, Lucía, Morante, Isla, and Escalante, Patricio

Abstract

Abstract Rationale The tuberculin skin test (TST) and interferon ? release assays (IGRAs) are commonly used for latent tuberculosis infection (LTBI) screening. Unexpectedly high TST positivity rates have been reported in patients with rheumatic diseases, and methotrexate is frequently used in this population. We hypothesized that methotrexate use could be associated with false-positive TST results. Objectives To investigate whether treatment with methotrexate and other factors are associated with false-positive TST results in patients with rheumatic diseases. Methods Prospective single-center study conducted between April 2013 and March 2016. Adult patients with rheumatic diseases were evaluated with a TST and two IGRAs for LTBI screening. We compared TST and IGRA results in patients treated and not treated with methotrexate and analyzed for factors associated with positive TST results. Conclusions Our data suggest false-positive TST results associated with methotrexate therapy. Thus, we recommend against using the TST for LTBI screening in patients receiving methotrexate and the preferential use of IGRAs in such patients. Measurements and Main Results We studied 393 patients with rheumatic diseases, including ankylosing spondylitis (ASP, n = 90), rheumatoid arthritis (RA; n = 120), psoriatic arthritis (PA, n = 126), and other disorders (n = 57). The rate of TST positivity varied across the groups: ASP 22.2%, RA 25%, PA 35.7%, and other disorders (22.8%). Positivity rates were lower with IGRAs. Methotrexate use was associated with a statistically significant two-fold increase in the risk of a positive TST and a dose\x96 response relationship was observed. We found no statistically significant associations between methotrexate use and IGRA test positivity. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

211. Serial Tuberculin Skin Tests Improve the Detection of Latent Tuberculosis Infection in Patients With Inflammatory Bowel Disease.

Author

Taxonera, Carlos, Ponferrada, Ángel, Riestra, Sabino, Bermejo, Fernando, Saro, Cristina, Martín-Arranz, María Dolores, Cabriada, José Luis, Acosta, Manuel Barreiro-de, Castro, María Luisa de, and López-Serrano, Pilar

Abstract

Aim To assess the likelihood of detecting latent tuberculosis infection [LTBI] by the positive conversion of a serial tuberculin skin test [TST] at 1 year in inflammatory bowel disease [IBD] patients with negative baseline two-step TST. Methods In this multicentre prospective cohort study, we evaluated rate and predictors of conversion of TST at 1 year in patients with negative baseline TST. We also evaluated management of patients who had a positive TST at baseline or a conversion at 1 year. In all patients we assessed TB cases occurring during follow-up. Results Of the 192 IBD patients receiving anti-tumour necrosis factor [TNF] and 220 IBD controls not receiving anti-TNF, 35 [8.5%, 95% CI 5.7–11.3] had positive conversion (median TST induration 13 mm, interquartile range [IQR] 9–16). Ten anti-TNF cohort patients [5.2%, 95% CI 2.5–9.5] versus 25 controls [11.4%, 95% CI 7.5–16.3] had TST conversion [ p = 0.029]. In multivariate analysis, conversion was associated with smoking habit (odds ratio [OR] 2.19, 95% CI 1.08–3.97; p = 0.028). Anti-TNF-treated patients had a lower conversion rate [OR 0.41, 95% CI 0.20–0.83; p = 0.013]. The likelihood of conversion correlates with fewer immunosuppressive therapies between baseline TST and TST at 1 year [ p = 0.042]. One case of active TB [isoniazid-resistant strain] occurred in a patient with positive baseline TST receiving anti-TNF [0.05 events/100 patient-years]. Conclusions Serial TST at 1 year can detect LTBI in IBD patients receiving anti-TNF therapy with negative baseline TST. Serial TST seems to be advisable to reduce the risk of TB cases associated with inability to detect LTBI in pre-treatment screening. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

212. ¿Quién decide qué datos deben constar en la historia clínica en relación con el origen biológico?

Author

Gallego Riestra, Sergio and Riaño Galán, Isolina

Abstract

Cada vez es más frecuente que se produzcan peticiones de pacientes o de sus representantes relativas a que determinada información no quede registrada en la historia clínica o que, si ya lo está, se elimine. Sin duda esto es debido a que saben que a los historiales clínicos acceden numerosos profesionales que en muchas ocasiones no guardan una relación estrictamente asistencial con ellos y que de manera generalizada se copian antecedentes médicos que de forma innecesaria se reproducen en los diversos informes de alta o de asistencia. El problema produce situaciones de conflicto cuando los datos objeto de controversia hacen referencia a aspectos clínicos especialmente sensibles para la intimidad personal y familiar, como ocurre con las técnicas de reproducción asistida. Por ello, la pregunta que cabe formular es: ¿quién decide qué datos deben constar en la historia clínica y en función de qué criterios debe tomarse esa decisión?

Published
2024
Full Text
View/download PDF

215. Risk factors for tuberculosis in inflammatory bowel disease: anti-tumor necrosis factor and hospitalization

Author

Sabino Riestra, Ruth de Francisco, Miguel Arias-Guillén, Cristina Saro, María García-Alvarado, José M. Duque, Juan José Palacios, Fernando Muñoz, Lorena Blanco, Olegario Castaño, Isabel Pérez-Martínez, Pablo Martínez-Camblor, Dolores Pérez-Hernández, and Adolfo Suárez

Subjects
Tuberculosis, Inflammatory bowel disease, Risk factors, Anti-TNF, Hospitalization, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Aims: To determine risk factors for active tuberculosis in patients with inflammatory bowel diseases. Methods: Retrospective, case-control study at 4 referral hospitals in Spain. Cases developed tuberculosis after a diagnosis of inflammatory bowel disease. Controls were inflammatory bowel disease patients who did not develop tuberculosis. For each case, we randomly selected 3 controls matched for sex, age (within 5 years) and time of inflammatory bowel disease diagnosis (within 3 years). Inflammatory bowel disease characteristics, candidate risk factors for tuberculosis and information about the tuberculosis episode were recorded. Multivariate analysis and a Chi-squared automatic interaction detector were used. Results: Thirty-four cases and 102 controls were included. Nine of the 34 cases developed active tuberculosis between 1989 and 1999, and 25 became ill between 2000 and 2012. Multivariate regression showed an association between active tuberculosis and anti-TNF (tumor necrosis factor) therapy in the previous 12 months (OR 7.45; 95% CI, 2.39-23.12; p = 0.001); hospitalization in the previous 6 months (OR 4.38; 95% CI, 1.18-16.20; p = 0.027); and albumin levels (OR 0.88; 95% CI, 0.81-0.95; p = 0.001). The median time between the start of biologic therapy and the onset of active tuberculosis was 13 (interquartile range, 1-58) months. Tuberculosis developed after a year of anti-TNF therapy in 53%, and late reactivation occurred in at least 3 of 8 patients. Conclusions: The main risks factors for developing tuberculosis were anti-TNF therapy and hospitalization. Over half the cases related to anti-TNF treatment occurred after a year.

Full Text
View/download PDF

219. Hall-Petch equation in a hypoeutectic Al-Si cast alloy: grain size vs. secondary dendrite arm spacing.

Author

Ghassemali, Ehsan, Riestra, Martin, Bogdanoff, Toni, Kumar, Bharath S., and Seifeddine, Salem

Subjects
ALUMINUM alloys, HYPOEUTECTIC alloys, GRAIN size, DENDRITIC crystals, MECHANICAL loads
Abstract

The Al-Si cast alloy family is widely used in the production of complex castings for various applications and known for its very good castability and high strength-to-weight ratio. However, early cracking under tensile loading is sometimes a limiting factor. Among other parameters, it is yet controversial whether grain boundaries are dominant strengthening factor in cast alloys, instead of dendrite/eutectic boundaries. This study presents the effect of secondary dendrite arm spacing (SDAS) and grain size on crack initiation and propagation of Al-Si cast alloys under tensile loading. The Al-10Si (wt.%) alloy with modified Si morphology was cast using inoculants (Al-5Ti-B master alloy) under different cooling rates to obtain a range of grain sizes (from below 138 µm to above 300 µm) and SDAS (6, 15 and 35 µm). Conventional tensile test as well as in-situ tensile test in a scanning electron microscope, equipped with an electron backscatter diffraction (EBSD) was carried out to understand the deformation mechanisms of the alloy. Observation of slip bands within the dendrites showed that in modified Si structure, the interdendritic (eutectic) area takes more portion of the strain during plastic deformation. Besides, only a few cracks were initiated at the grain boundaries; they were mostly initiated from dendrite/eutectic interface. All cracks propagated trans-granularly. Hall-Petch calculations also showed a strong relationship between SDAS and flow stress of the cast alloy. Although statistically correct, there was no physically meaningful relationship between the grain size and the flow stress. Nevertheless, formation of identical slip bands in each grain could be an evidence for the marginal effect of the grain size on the overall strength development of the alloy. Consequently, among other effects, the combinational dominant effect of SDAS and modest effect of grain size shall be considered for modification of the Hall-Petch equation for precise prediction of mechanical properties of cast alloys. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

220. Modos de fallecimiento de los niños en Cuidados Intensivos en España. Estudio MOMUCIP (modos de muerte en UCIP)

Author

Agra Tuñas, María Carmen, Pilar Orive, Francisco Javier, Merino, Elva Rodríguez, López-Herce Cid, Jesús, Martín, Gema Manrique, Casas, Paula García, González, Arturo Hernández, Fraga, Carmen Ramil, Galán, Corsino Rey, Riestra Rodríguez, María Rosario, Rastrollo, Ramón Hernández, Carrión, Francisco Fernández, and Núñez, Antonio Rodríguez

Abstract

Describir los modos de muerte de los niños en las Unidades de Cuidados Intensivos Pediátricos (UCIP) en España y analizar las características de aquellos que fallecen tras decidir una limitación del esfuerzo terapéutico (LET).

Published
2019
Full Text
View/download PDF

221. Type 1 diabetes mellitus prevalence and care in children under 15 years old in Asturias

Author

Osorio Álvarez, Sofía, Riestra Rodríguez, María del Rosario, López Sánchez, Raquel, Alonso Pérez, Fernando, and Oltra Rodríguez, Enrique

Abstract

Prevalence of type 1 diabetes mellitus (T1DM) is increasing worldwide. Care provided appears to have an influence on the course of disease. The aim of this study was to ascertain the prevalence of T1DM and to collect data on the resources and care used in Asturias.

Published
2019
Full Text
View/download PDF

222. Prevalencia y datos asistenciales de la diabetes mellitus tipo 1 en menores de 15 años en Asturias

Author

Osorio Álvarez, Sofía, Riestra Rodríguez, María del Rosario, López Sánchez, Raquel, Alonso Pérez, Fernando, and Oltra Rodríguez, Enrique

Abstract

La prevalencia de diabetes mellitus 1 (DM1) está aumentando en todo el mundo. La atención recibida parece tener influencia en la evolución de la enfermedad. El objetivo es conocer la prevalencia de DM1, así como los recursos y datos asistenciales que se están utilizando en Asturias.

Published
2019
Full Text
View/download PDF

225. Anatomical criteria to measure the adult right liver lobe by ultrasound

Author

Riestra‐Candelaria, Bárbara L., Rodriguez‐Mojica, Wilma, and Jorge, Juan Carlos

Abstract

This study aims to establish objective anatomical criteria to obtain accurate and reliable measurements of the right liver lobe (RLL) length by ultrasound while considering sex and anthropometry of the patient. Thirty‐three (n= 33) adult participants underwent two‐dimensional (2D) and panoramic (PAN) ultrasound imaging of the RLL in the anterior axillary region. Each measurement was performed in the standard oblique plane and in a tested craniocaudal (CC) plane by two independent observers. Pearson analysis was conducted to evaluate correlation between measurements and intraclass correlation coefficient for inter‐rater reliability. Two‐tail paired ttest was used to compare groups. Statistical significance was attained at p< 0.05. The proposed CC 2D RLL length was 13.0 ± 1.5 cm for women and 14.1 ± 1.3 cm for men whereas PAN RLL size was 13.7 ± 1.8 cm for women and 15.0 ± 1.1 cm for men. A strong correlation between the proposed 2D CC measurement of the RLL length with PAN CC measurements was found (r= 0.87). Inter‐rater reliability for 2D CC measurements showed high reliability (intraclass correlation coefficient 0.96). Craniocaudal measurement of RLL by ultrasound in anterior axillary region is a precise and reliable measurement that may allow for the routine monitoring of RLL length across time.

Published
2018
Full Text
View/download PDF

226. Trichomonas vaginalisInduces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages

Author

Riestra, Angelica Montenegro, Valderrama, J. Andrés, Patras, Kathryn A., Booth, Sharon D., Quek, Xing Yen, Tsai, Chih-Ming, and Nizet, Victor

Abstract

Trichomonas vaginalisis a sexually transmitted, eukaryotic parasite that causes trichomoniasis, the most common nonviral, sexually transmitted disease in the USA and worldwide. Little is known about the molecular mechanisms involved in the host immune response to this widespread parasite. Here we report that T. vaginalisinduces NLRP3 inflammasome activation in human macrophages, leading to caspase-1 activation and the processing of pro-IL-1β to the mature and bioactive form of the cytokine. Using inhibitor-based approaches, we show that NLRP3 activation by T. vaginalisinvolves host cell detection of extracellular ATP via P2X7receptors and potassium efflux. In addition, our data reveal that T. vaginalisinflammasome activation induces macrophage inflammatory cell death by pyroptosis, known to occur via caspase-1 cleavage of the gasdermin D protein, which assembles to form pores in the host cell membrane. We found that T. vaginalis-induced cytolysis of macrophages is attenuated in gasdermin D knockout cells. Lastly, in a murine challenge model, we detected IL-1β production in vaginal fluids in response to T. vaginalisinfection in vivo. Together, our findings mechanistically dissect how T. vaginaliscontributes to the production of the proinflammatory IL-1β cytokine and uncover pyroptosis as a mechanism by which the parasite can trigger host macrophage cell death.

Published
2018
Full Text
View/download PDF

231. Association of the Q223R polymorphism with age at menarche in the leptin receptor gene in humans

Author

M. de Oya, M.J. Bayonas, Carmen Garcés, P. Riestra, A. Torres-Cantero, and A. Garcia-Anguita

Subjects
medicine.medical_specialty, Adolescent, Population, Adipokine, Biology, Polymorphism, Single Nucleotide, Gene Frequency, Polymorphism (computer science), Internal medicine, parasitic diseases, Genotype, medicine, Humans, education, Child, Genetic Association Studies, Menarche, education.field_of_study, Leptin, Age Factors, Cell Biology, General Medicine, Leptin Receptor Gene, Genotype frequency, Endocrinology, Cross-Sectional Studies, Reproductive Medicine, Amino Acid Substitution, Spain, Receptors, Leptin, Female
Abstract

Although genetics clearly influences the onset of menarche, the association of age at menarche (AAM) with variants in genes related to energy homeostasis remains unexplored. Our aim was to analyze the relationship of the Q223R polymorphism in the leptin receptor gene (LEPR(Q223R)) with AAM in a population-based sample of healthy pubertal girls. The study included 338 Spanish girls aged between 11 and 17 yr. Data were collected on AAM. The Q223R polymorphism in LEPR was detected by TaqMan allelic discrimination assays. Girls carrying the RR genotype had a significantly younger AAM (11.5 yr) than those carrying the QR (11.9 yr) or QQ (12.0 yr) genotype (P0.05). Furthermore, we found a significantly higher frequency of the RR genotype in girls with an AAM of 11 yr or younger than in girls with an AAM older than 12 yr (23.9% vs. 7.8%, χ(2) = 11.17, P = 0.0008). Also, the RR genotype frequency in girls with an AAM between 11 and 12 yr was significantly higher than in girls with an AAM older than 12 yr (16.8% vs. 7.8%, χ(2) = 3.97, P = 0.0046). The Q223R polymorphism in the LEPR gene is associated with variations in AAM among Spanish girls, with the RR genotype being related to earlier onset.

Published
2010

232. Sex-specific association between leptin receptor polymorphisms and leptin levels and BMI in healthy adolescents

Author

P, Riestra, A, García-Anguita, S, Schoppen, L, López-Simón, M, De Oya, and C, Garcés

Subjects
Leptin, Male, Chi-Square Distribution, Adolescent, Genotype, Polymorphism, Single Nucleotide, White People, Body Mass Index, Cross-Sectional Studies, Phenotype, Sex Factors, Spain, Body Composition, Humans, Receptors, Leptin, Female, Child
Abstract

To examine the relationship of three common polymorphisms in the leptin receptor (LEPR) gene, implicated in the regulation of body weight, with leptin levels and obesity-related phenotypes in a population-based sample of healthy pubertal children in Spain.The study included 806 boys and girls aged 12-16 whose anthropometrical data and body composition were recorded. Serum leptin levels were determined by ELISA. The LEPR Q223R, K109R and K656N polymorphisms were determined by TaqMan® allelic discrimination assays.When analysing the Q223R polymorphism, we observed that female carriers of the RR genotype had significantly higher plasma leptin levels (18.2 vs. 15.1 ng/mL p = 0.016) and significantly higher mean BMI values (22.5 vs. 21.3 Kg/m² p = 0.032) than QR carriers. Furthermore, the frequency of the RR genotype in overweight-obese girls was significantly higher than that found in normal-weight girls. No significant differences were observed in boys. Neither boys nor girls showed significant differences when comparing leptin levels, anthropometric variables or body composition by K109R or K656N genotype.The fact, that the Q223R polymorphism in the LEPR gene is significantly associated with leptin levels and BMI only in girls, suggests a sex-specific influence of this polymorphism on these variables.

Published
2010

233. ¿TIENEN LOS PACIENTES PORTADORES DE PRÓTESIS ARTICULAR MAYOR RIESGO DE DESARROLLO DE ENDOCARDITIS INFECCIOSA TRAS UNA BACTERIEMIA POR S. AUREUS?

Author

de la Rosa Riestra, S, Martínez Pérez-Crespo, PM, Fernández-Natal, I, Goikoetxea-Aguirre, AJ, Sousa-Domínguez, A, Armiñanzas-Castillo, C, Morán Rodríguez, MÁ, Fernández-Suárez, J, Reguera-Iglesias, JM, Jóver-Saenz, A, Sánchez-Calvo, JM, Natera Kindelán, C, López Hernández, I, Rodríguez Baño, J, and López Cortés, LE

Published
2023
Full Text
View/download PDF

235. Early Tuberculin Skin Test for the Diagnosis of Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease.

Author

Taxonera, Carlos, Ponferrada, Ángel, Bermejo, Fernando, Riestra, Sabino, Saro, Cristina, Martín-Arranz, María Dolores, Cabriada, José Luis, Acosta, Manuel Barreiro-de, de Castro, María Luisa, López-Serrano, Pilar, Barrio, Jesús, Suarez, Cristina, Iglesias, Eva, Argüelles-Arias, Federico, Ferrer, Isabel, Marín-Jiménez, Ignacio, Hernández-Camba, Alejandro, Bastida, Guillermo, Domselaar, Manuel Van, and Martínez-Montiel, Pilar

Abstract

Background and Aim: Sensitivity of tuberculin skin test [TST] during screening for latent tuberculosis infection [LTBI] is affected by steroid and/or immunosuppressant therapy. The aim of this study was to compare performance of the two-step TST in inflammatory bowel disease patients immediately before anti-tumour necrosis factor [TNF] therapy as part of routine screening for LTBI vs control patients when the TST was carried out at an early stage. Methods: In this multicentre prospective controlled study, we evaluated the performance of two-step TST with 5-mm threshold. Factors associated with TST results were determined by logistic regression. Results: We evaluated 243 candidates for anti-TNF therapy and 337 control patients. Overall, 105 patients [18.1%] had an induration = 5 mm in the first TST or in TST retest. LTBI was diagnosed in 25% of patients by TST retest. Twenty-eight [11.5%] anti-TNF group patients vs 77 [22.8%] control patients had a positive TST (odds ratio [OR] 0.44, 95% confidence interval [CI] 0.28-0.70; P < 0.001]. In multivariate analysis, positive TST was associated with higher age [OR 2.63, 95% CI 1.21-5.72; P < 0.001] and 5-aminosalicylate therapy [OR 1.86, 95% CI 1.14-3.05; P = 0.013]. Negative TST was associated with steroid therapy [OR 0.36, 95% CI 0.16-0.83; P = 0.016], immunosuppressant therapy [OR 0.36, 95% CI 0.21-0.62; P < 0.001], or steroids + immunosuppressant therapy [OR 0.20, 95% CI 0.07-0.59; P = 0.004]. Conclusions: The sensitivity of routine TST performed just before starting anti-TNF therapy is low. TST performed at an early stage enables screening in the absence of immunosuppressive treatment and thus maximises the diagnostic yield of TST for detecting LTBI. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

236. La concepción del diálogo de los rusos desde la perspectiva interaccionista socio-discursiva.

Author

Riestra, Dora

Abstract

Copyright of Revista Veredas is the property of Revista Veredas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017

237. A survey of the video game industry in Portugal.

Author

Santos, Pedro A., Romeiro, Patrícia, Nunes, Flávio, Hollins, Paul, and Riestra, Ruben

Subjects
VIDEO game industry, VIDEO games
Abstract

Copyright of Revista de Ciências da Computação is the property of Universidade Aberta and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017

238. Consensus SEO-SEFH of recommendations for use and compounding of ophthalmic preparations

Author

Fuentes-Irigoyen, Raquel, de Rosales Cabrera, Ana María Martín, Riestra, Ana Cristina, Vila, María Nieves, Dávila-Pousa, Carmela, Herreros, José María Alonso, López-Cabezas, Carmen, Cañete, Carme, Pernía-López, María Sagrario, García-Palomo, Marta, Villalobos, Pedro Arriola, Ibares-Frías, Lucía, Segura, José Luis Urcelay, and Martínez, Jacobo Ramón Yañez

Abstract

There are many medicinal products that, although having shown efficacy and safety in different ophthalmological indications, they are not authorized or commercially available for ophthalmic administration. This implies, on one hand, that they must be used according to legislation that regulates the availability of medicines in special situations and, on the other hand, that they must be prepared in the pharmacy services for ophthalmic administration, according to quality criteria to ensure its effectiveness, stability and sterility. This document gathers the consensus between the Spanish Society of Ophthalmology and the Spanish Society of Hospital Pharmacy about these selected preparations which have shown enough evidence in their efficacy and safety for their ophthalmic use (off label) and ophthalmic administration. This document includes recommendations about its use according to the current legislation. In addition, with the aim of harmonizing the preparation of intraocular injections in the hospital pharmacy services, general recommendations are set in this document to ensure the compliance with standards established in the Spanish Guideline for GoodPreparation Practices of Medicinal Products in Hospital Pharmacies.These recommendations include sections such as the area of preparation, material, technique, packaging, stability, quality control, prescription and traceability of intraocular preparations.

Published
2018
Full Text
View/download PDF

239. ¿Son complejos los pacientes atendidos por unidades de cuidados paliativos domiciliarias?

Author

de Miguel, Cristina, Ruiz, Susana, de la Uz, Ana, Merino, Elena, Gutierrez, Aránzazu, Sanz, Lara, Molinero, Eugenia, Sanz, M. Esther, Navarro, Asunción, and Riestra, Ana

Abstract

Determinar el grado de complejidad de los pacientes atendidos por un Equipo de Soporte de Atención Domiciliaria Paliativa (ESAPD) urbano y un ESAPD urbano y rural, medida mediante el Instrumento de Complejidad Paliativa (IDC-Pal).

Published
2018
Full Text
View/download PDF

240. Small depth long-span timber floor design with self-tensioned systems

Author

Otero-Chans, Dolores, Estévez-Cimadevila, Javier, Suárez-Riestra, Félix, and Pérez-Valcárcel, Juan

Abstract

AbstractThe design of long-span timber floors, which are able to bear overloaded public spaces, requires the use of beams with large depths to meet the requirements of the serviceability limit state. This article studies the use of a self-tensioning system that, in combination with a pre-stressing, allows designing wooden structural floors that are able to remain practically horizontal in service load situations with depths that are no greater than 1/30 of the span. Several situations are studied, with spans between 9 and 18 m and variable loads of 3.0 and 5.0 kN/m2. These situations obtain deflections below 1/1000 of the span under a total load set-up.

Published
2018
Full Text
View/download PDF

241. Estado nutricional de yodo en la población escolar asturiana

Author

Riestra Fernández, María, Menéndez Torre, Edelmiro, Díaz Cadórniga, Francisco, Fernández Fernández, Juan Carlos, and Delgado Álvarez, Elías

Abstract

El déficit de yodo es considerado un problema de salud pública. El estado nutricional de yodo de una población debería determinarse periódicamente.

Published
2017
Full Text
View/download PDF

242. Iodine nutritional status in Asturian schoolchildren

Author

Riestra Fernández, María, Menéndez Torre, Edelmiro, Díaz Cadórniga, Francisco, Fernández Fernández, Juan Carlos, and Delgado Álvarez, Elías

Abstract

Iodine deficiency is a public health problem, and iodine nutritional status should therefore be regularly measured.

Published
2017
Full Text
View/download PDF

244. Patient satisfaction in the management of mild-to-moderate ulcerative colitis: Results of a Delphi study among patients and physicians.

Author

Casellas, Francesc, Ginard, Daniel, and Riestra, Sabino

Abstract

Goals To determine factors contributing to satisfaction with treatment in mild-to-moderate ulcerative colitis (UC) from both the patients and the physicians perspectives. Background Despite the impact of UC on different aspects of daily life, patient's and physician's satisfaction with clinical management has been poorly evaluated. Study A Delphi study involving 22 patients and 20 clinicians was conducted. The patient's questionnaire included 285 items regarding diagnosis, treatment, and follow-up, whereas the physician's questionnaire added 32 specific items for clinicians. Relevance of items was scored from 1 (not at all important) to 9 (very important). Recommendations were based on very highly rated items. Results Most items were rated consistently by patients and physicians with some exceptions. Patients emphasized the choice of moderate flare-ups to be followed at the hospital setting rather than in primary care as well as to be informed on aspects, such as diet and impact of UC on their health and lifestyle. Treatment-related efficacy, safety, and improved quality of life were relevant for both patients and physicians. Physicians believed that to reduce pill burden was a crucial aspect to improve patient's satisfaction. Patients preferred oral administration treatment over rectal treatment. Conclusions The study identified specific aspects related to the management of mild-to-moderate UC that both patients and physicians considered to be highly relevant for patient satisfaction. Recommendation based on these factors would be important at the time of designing and implementing strategies targeting satisfaction in UC patients. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

245. DUELO PROLONGADO Y FACTORES ASOCIADOS.

Author

Estevan Burdeus, Patricia, De Miguel Sánchez, Cristina, Álvarez Álvarez, Roberto, Martín Molpeceres, Esther, Múgica Aguirre, Borja, Riestra Fernández, Ana, Gutiérrez Ruiz, Aránzazu, Sanz Venturerira, Lara, Vicente Sánchez, Fernando, García Jiménez, Gema, García Oliva, Francisco Javier, Cristóbal Saenz de Manjares, Rhut, Corral Rubio, Amparo, Bonivento Martínez, Vanesa, Guechoum González, José Antonio, Carrera Lavín, María, López Rodríguez, María Jesús, Morán Tiesta, Cristina, and Del Cura González, Isabel

Abstract

Copyright of Psicooncologia is the property of Universidad Complutense de Madrid and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016
Full Text
View/download PDF

247. Autologous method for ex vivoexpansion of human limbal epithelial progenitor cells based on plasma rich in growth factors technology

Author

Riestra, A.C., Vazquez, N., Chacon, M., Berisa, S., Sanchez-Avila, R.M., Orive, G., Anitua, E., Meana, A., and Merayo-Lloves, J.

Abstract

Develop an autologous culture method for ex vivoexpansion of human limbal epithelial progenitor cells (LEPCs) using Plasma Rich in Growth Factors (PRGF) as a growth supplement and as a scaffold for the culture of LEPCs.

Published
2017
Full Text
View/download PDF

248. ENSAYO CLÍNICO ALEATORIZADO COMPARATIVO DEL EFECTO DE MEGABOLOS DE CORTICOIDES INTRAVENOSOS AÑADIDOS A LOS CORTICOIDES ORALES EN EL TRATAMIENTO DE LA CU CON ACTIVIDAD MODERADA

Author

LLaó, Jordina, Mañosa, Míriam, Martín-Arranz, Eduardo, Zabana, Yamile, Navarro-Llavat, Mercè, Garcia-Planella, Esther, Busquets, David, Monfort, David, Pineda, Juan-Ramón, Gutiérrez, Ana, Villoria, Albert, Menchén, Luis, Bastida, Guillermo, García-Alonso, Francisco Javier, Rivero, Montserrat, Chaparro, María, Riestra, Sabino, Merino, Olga, Lago, Iago Rodríguez-, Acosta, Manuel Barreiro-de, and Domènech, Eugeni

Published
2023
Full Text
View/download PDF

249. CARACTERIZACIÓN PROTEÓMICA DE LAS VESÍCULAS EXTRACELULARES SÉRICAS DE PACIENTES RECIÉN DIAGNOSTICADOS DE ENFERMEDAD INFLAMATORIA INTESTINAL

Author

Soleto, Irene, Baldan-Martín, Montse, Ramirez, Cristina, Orejudo, Macarena, García, Sara, Mercado, Jorge, Azkargorta, Mikel, Iloro, Ibon, Moreno, Lorena Ortega, Garcia, Laila Aldars, Riestra, Sabino, Rivero, Montserrat, Gutierrez, Ana, Rodríguez-Lago, Iago, Fernández, Luis, Ceballos, Daniel, Benitez, Jose Manuel, Aguas, Mariam, Rey, Iria Bastón, Bermejo, Fernando, Casanova, Maria Jose, Llorente, Rufo, Ber, Yolanda, Ginard, Daniel, Esteve, Maria, Elortza, Felix, Gisbert, Javier P, Martín-Cofreces, Noa, and Chaparro, Maria

Published
2023
Full Text
View/download PDF

250. EFICACIA Y SEGURIDAD DEL TRATAMIENTO DE RESCATE EN LA COLITIS ULCEROSA CORTICORREFRACTARIA GRAVE REFRACTARIA A INFLIXIMAB O CICLOSPORINA (ESTUDIO REASUC)

Author

García, María José, Riestra, Sabino, Amiot, Aurelien, Julsgaard, Mette, de la Filia, Irene García, Calafat, Margalida, Aguas, Mariam, de la Peña, Luisa, Roig-Ramos, Cristina, Caballol, Berta, Casanova, María José, Farkas, Klaudia, Boysen, Trine, Bujanda, Luis, Cuarán, Camila, Dobru, Daniela, Fousekis, Fotios, Gargallo-Puyuelo, Carla Jerusalén, Savarino, Edoardo, Calvet, Xavier, Huguet, José María, Kupcinskas, Limas, López-Cardona, Julia, Raine, Tim, van Oostrom, Joep, Gisbert, Javier P., and Chaparro, María

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results