6,261 results on '"P. Padmanabhan"'
Search Results
202. Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation
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Dumesic, Daniel A, Padmanabhan, Vasantha, Chazenbalk, Gregorio D, and Abbott, David H
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Obesity ,Contraception/Reproduction ,Nutrition ,Infertility ,Prevention ,Diabetes ,Metabolic and endocrine ,Reproductive health and childbirth ,Adaptation ,Physiological ,Adult ,Animals ,Energy Metabolism ,Female ,Humans ,Hyperandrogenism ,Insulin Resistance ,Menstruation Disturbances ,Metabolic Syndrome ,Polycystic Ovary Syndrome ,Polycystic ovary syndrome ,Insulin resistance ,Adipocyte ,Adipose stem cells ,Developmental programming ,Nonhuman primates ,Sheep ,Body fat distribution ,Metabolic adaptation ,Biological Sciences ,Medical and Health Sciences ,Obstetrics & Reproductive Medicine ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
As a common endocrinopathy of reproductive-aged women, polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo-anovulation and polycystic ovarian morphology. It is linked with insulin resistance through preferential abdominal fat accumulation that is worsened by obesity. Over the past two millennia, menstrual irregularity, male-type habitus and sub-infertility have been described in women and confirm that these clinical features of PCOS were common in antiquity. Recent findings in normal-weight hyperandrogenic PCOS women show that exaggerated lipid accumulation by subcutaneous (SC) abdominal stem cells during development to adipocytes in vitro occurs in combination with reduced insulin sensitivity and preferential accumulation of highly-lipolytic intra-abdominal fat in vivo. This PCOS phenotype may be an evolutionary metabolic adaptation to balance energy storage with glucose availability and fatty acid oxidation for optimal energy use during reproduction. This review integrates fundamental endocrine-metabolic changes in healthy, normal-weight PCOS women with similar PCOS-like traits present in animal models in which tissue differentiation is completed during fetal life as in humans to support the evolutionary concept that PCOS has common ancestral and developmental origins.
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- 2022
203. Structural and refractive outcomes of intravitreal ranibizumab followed by laser photocoagulation for type 1 retinopathy of prematurity
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Hoppe, Charis, Holt, Derick G, Arnold, Benjamin F, Thinda, Sumeer, Padmanabhan, Sriranjani P, and Oatts, Julius T
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Pediatric ,Eye Disease and Disorders of Vision ,Infant Mortality ,Perinatal Period - Conditions Originating in Perinatal Period ,Eye ,Infant ,Infant ,Newborn ,Humans ,Child ,Preschool ,Ranibizumab ,Retinopathy of Prematurity ,Bevacizumab ,Retrospective Studies ,Angiogenesis Inhibitors ,Intravitreal Injections ,Laser Coagulation ,Vascular Endothelial Growth Factor A ,Gestational Age ,Myopia ,Clinical Sciences ,Ophthalmology & Optometry ,Clinical sciences ,Ophthalmology and optometry - Abstract
PurposeTo evaluate refractive and structural outcomes for patients treated for retinopathy of prematurity (ROP) with the anti-vascular endothelial growth factor (anti-VEGF) agent ranibizumab and "delayed laser," defined as any laser photocoagulation treatment administered at least 2 weeks and
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- 2022
204. Origins of multi-sublattice magnetism and superexchange interactions in double-double perovskite CaMnCrSbO6
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Dhawan, Rakshanda, Balasubramanian, Padmanabhan, and Nautiyal, Tashi
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Condensed Matter - Materials Science ,Condensed Matter - Strongly Correlated Electrons - Abstract
We have deployed density functional theory, Wannier function analysis and mean-field calculations to investigate the double-double perovskite compound CaMnCrSbO_{6}. The crystallographically non-equivalent Mn atoms in the unit cell have tetrahedral and planar oxygen coordinations (labelled as Mn(1) and Mn(2)), while the Cr atom is in the centre of distorted oxygen octahedron. While the bulk magnetization and neutron diffraction suggest a simpler ferrimagnetic order (T_C=49 K) between Mn2+ and Cr3+ spins, the exchange interactions are more complex than that expected from a two sublattice magnetic system. The electronic structure calculations yield a ferrimagnetic insulating ground state even in absence of Hubbard U which persists for a wide range of U. The Mn(1)-O-Mn(2) (out of plane and in-plane), Mn(1)-O-Cr and Mn(2)-O-Cr superexchange interactions are found to be anti-ferromagnetic, while the Cr-O-O-Cr super-superexchange is found to be ferromagnetic. The Mn(2)-O-Cr superexchange is weaker than the Mn(1)-O-Cr superexchange, thus effectively resulting in ferrimagnetism. From a simple 3-site Hubbard model, we derived expressions for the antiferromagnetic superexchange strength J_AFM and the weaker ferromagnetic J_FM. The relative strengths of JAFM for the various superexchange interactions are in agreement with those obtained from DFT. The expression for Cr-O-O-Cr super-superexchange strength (J_SS), which is derived considering a 4-site Hubbard model, predicts a ferromagnetic exchange in agreement with DFT. Finally, our mean field calculations reveal that assuming a set of four magnetic sub-lattice for Mn2+ spins and a single magnetic sublattice for Cr3+ spins yields a much improved T_C, while a simple two magnetic sublattice model yields a much higher T_C., Comment: 29 pages, 11 figures
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- 2022
205. Self-Programming Artificial Intelligence Using Code-Generating Language Models
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Sheng, Alex and Padmanabhan, Shankar
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Computer Science - Artificial Intelligence ,Computer Science - Machine Learning ,68T07 ,I.2.0 - Abstract
Recent progress in large-scale language models has enabled breakthroughs in previously intractable computer programming tasks. Prior work in meta-learning and neural architecture search has led to substantial successes across various task domains, spawning myriad approaches for algorithmically optimizing the design and learning dynamics of deep learning models. At the intersection of these research areas, we implement a code-generating language model with the ability to modify its own source code. Self-programming AI algorithms have been of interest since the dawn of AI itself. Although various theoretical formulations of generalized self-programming AI have been posed, no such system has been successfully implemented to date under real-world computational constraints. Applying AI-based code generation to AI itself, we develop and experimentally validate the first practical implementation of a self-programming AI system. We empirically show that a self-programming AI implemented using a code generation model can successfully modify its own source code to improve performance and program sub-models to perform auxiliary tasks. Our model can self-modify various properties including model architecture, computational capacity, and learning dynamics.
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- 2022
206. Large Itinerant Electron Exchange Coupling in the Magnetic Topological Insulator MnBi2Te4
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Padmanabhan, Hari, Stoica, Vladimir A., Kim, Peter, Poore, Maxwell, Yang, Tiannan, Shen, Xiaozhe, Reid, Alexander H., Lin, Ming-Fu, Park, Suji, Yang, Jie, Wang, Huaiyu, Koocher, Nathan Z., Puggioni, Danilo, Min, Lujin, Lee, Seng-Huat, Mao, Zhiqiang, Rondinelli, James M., Lindenberg, Aaron M., Chen, Long-Qing, Wang, Xijie, Averitt, Richard D., Freeland, John W., and Gopalan, Venkatraman
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Condensed Matter - Materials Science ,Condensed Matter - Strongly Correlated Electrons - Abstract
Magnetism in topological materials creates phases exhibiting quantized transport phenomena with applications in spintronics and quantum information. The emergence of such phases relies on strong interaction between localized spins and itinerant states comprising the topological bands, and the subsequent formation of an exchange gap. However, this interaction has never been measured in any intrinsic magnetic topological material. Using a multimodal approach, this exchange interaction is measured in MnBi2Te4, the first realized intrinsic magnetic topological insulator. Interrogating nonequilibrium spin dynamics, itinerant bands are found to exhibit a strong exchange coupling to localized Mn spins. Momentum-resolved ultrafast electron scattering and magneto-optic measurements reveal that itinerant spins disorder via electron-phonon scattering at picosecond timescales. Localized Mn spins, probed by resonant X-ray scattering, disorder concurrently with itinerant spins, despite being energetically decoupled from the initial excitation. Modeling the results using atomistic simulations, the exchange coupling between localized and itinerant spins is estimated to be >100 times larger than superexchange interactions. This implies an exchange gap of >25 meV should occur in the topological surface states. By directly quantifying local-itinerant exchange coupling, this work validates the materials-by-design strategy of utilizing localized magnetic order to create and manipulate magnetic topological phases, from static to ultrafast timescales.
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- 2022
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207. On near-martingales and a class of anticipating linear SDEs
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Kuo, Hui-Hsiung, Shrestha, Pujan, Sinha, Sudip, and Sundar, Padmanabhan
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Mathematics - Probability ,60H10, 60F10, 60G48, 60G40 (Primary) 60H05, 60H07, 60H20 (Secondary) - Abstract
The primary goal of this paper is to prove a near-martingale optional stopping theorem and establish solvability and large deviations for a class of anticipating linear stochastic differential equations. We prove the existence and uniqueness of solutions using two approaches: (1) Ayed-Kuo differential formula using an ansatz, and (2) a novel braiding technique by interpreting the integral in the Skorokhod sense. We establish a Freidlin-Wentzell type large deviations result for solution of such equations., Comment: 23 pages, 2 figures
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- 2022
208. Ergodicity for Three-Dimensional Stochastic Navier-Stokes Equations with Markov Switching
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Hsu, Po-Han and Sundar, Padmanabhan
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Mathematics - Probability ,35Q30, 37L40, 60J75 - Abstract
Asymptotic behavior of the three-dimensional stochastic Navier-Stokes equations with Markov switching in additive noises is studied for incompressible fluid flow in a bounded domain in the three-dimensional space. To study such a system, we introduce a family of regularized equations and investigate the asymptotic behavior of the regularized equations first. The existence an ergodic measure for the regularized system is established via the Krylov-Bogolyubov method. Then the existence of an stationary measure to the original system is obtained by extracting a limit from the ergodic measures of the family of the regularized system., Comment: arXiv admin note: text overlap with arXiv:2203.14442
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- 2022
209. Three-Dimensional stochastic Navier-Stokes equations with Markov switching
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Hsu, Po-Han and Sundar, Padmanabhan
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Mathematics - Probability ,60H15, 76D05 - Abstract
A finite-state Markov chain is introduced in the noise terms of the three-dimensional stochastic Navier-Stokes equations in order to allow for transitions between two types of multiplicative noises. We call such systems as stochastic Navier-Stokes equations with Markov switching. To solve such a system, a family of regularized stochastic systems is introduced. For each such regularized system, the existence of a unique strong solution (in the sense of stochastic analysis) is established by the method of martingale problems and pathwise uniqueness. The regularization is removed in the limit by obtaining a weakly convergent sequence from the family of regularized solutions, and identifying the limit as a solution of the three-dimensional stochastic Navier-Stokes equation with Markov switching.
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- 2022
210. Transfer of codebook latent factors for cross-domain recommendation with non-overlapping data
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Veeramachaneni, Sowmini Devi, Pujari, Arun K, Padmanabhan, Vineet, and Kumar, Vikas
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Computer Science - Information Retrieval ,Computer Science - Machine Learning - Abstract
Recommender systems based on collaborative filtering play a vital role in many E-commerce applications as they guide the user in finding their items of interest based on the user's past transactions and feedback of other similar customers. Data Sparsity is one of the major drawbacks with collaborative filtering technique arising due to the less number of transactions and feedback data. In order to reduce the sparsity problem, techniques called transfer learning/cross-domain recommendation has emerged. In transfer learning methods, the data from other dense domain(s) (source) is considered in order to predict the missing ratings in the sparse domain (target). In this paper, we come up with a novel transfer learning approach for cross-domain recommendation, wherein the cluster-level rating pattern(codebook) of the source domain is obtained via a co-clustering technique. Thereafter we apply the Maximum Margin Matrix factorization (MMMF) technique on the codebook in order to learn the user and item latent features of codebook. Prediction of the target rating matrix is achieved by introducing these latent features in a novel way into the optimisation function. In the experiments we demonstrate that our model improves the prediction accuracy of the target matrix on benchmark datasets.
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- 2022
211. Multiple Estimation Models for Discrete-time Adaptive Iterative Learning Control
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Padmanabhan, Ram, Makam, Rajini, and George, Koshy
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Electrical Engineering and Systems Science - Systems and Control - Abstract
This article focuses on making discrete-time Adaptive Iterative Learning Control (ILC) more effective using multiple estimation models. Existing strategies use the tracking error to adjust the parametric estimates. Our strategy uses the last component of the identification error to tune these estimates of the model parameters. We prove that this strategy results in bounded estimates of the parameters, and bounded and convergent identification and tracking errors. We emphasize that the proof does not use the key technical lemma. Rather, it uses the properties of square-summable sequences. We extend this strategy to include multiple estimation models and show that all the signals are bounded, and the errors converge. It is also shown that this works whether we switch between the models at every instant and every iteration or at the end of every iteration. Simulation results demonstrate the efficacy of the proposed method with a faster convergence using multiple estimation models., Comment: 26 pages, 5 figures, 2 tables
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- 2022
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212. Analysis of Ferroelectric Negative Capacitance-Hybrid MEMS Actuator Using Energy-Displacement Landscape
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Raman, Raghuram Tattamangalam, Shibu, Jeffin, Padmanabhan, Revathy, and Ajoy, Arvind
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Electrical Engineering and Systems Science - Systems and Control - Abstract
We propose an energy-based framework to analyze the statics and dynamics of a ferroelectric negative capacitance-hybrid Microelectromechanical System (MEMS) actuator. A mapping function that relates the charge on the ferroelectric to displacement of the movable electrode, is used to obtain the Hamiltonian of the hybrid actuator in terms of displacement. We then use graphical energy-displacement and phase portrait plots to analyze static pull-in, dynamic pull-in and pull-out phenomena of the hybrid actuator. Using these, we illustrate the low-voltage operation of the hybrid actuator to static and step inputs, as compared to the standalone MEMS actuator. The results obtained are in agreement with the analytical predictions and numerical simulations. The proposed framework enables straightforward inclusion of adhesion between the contacting surfaces, modeled using van der Waals force. We show that the pull-in voltage is not affected, while the pull-out voltage is reduced due to adhesion. The proposed framework provides a physics-based tool to design and analyze negative capacitance based low-voltage MEMS actuators., Comment: 8 pages, 9 figures
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- 2022
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213. Discrete Robust Control of Robot Manipulators using an Uncertainty and Disturbance Estimator
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Padmanabhan, Ram, Shetty, Maithili, and Chandar, T. S.
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Electrical Engineering and Systems Science - Systems and Control - Abstract
This article presents the design of a robust observer based on the discrete-time formulation of Uncertainty and Disturbance Estimator (UDE), a well-known robust control technique, for the purpose of controlling robot manipulators. The design results in a complete closed-loop, robust, controller--observer structure. The observer incorporates the estimate of the overall uncertainty associated with the plant, in order to mimic its dynamics, and the control law is generated using an auxiliary error instead of state tracking error. A detailed qualitative and quantitative stability analysis is provided, and simulations are performed on the two-link robot manipulator system. Further, a comparative study with well-known control strategies for robot manipulators is presented. The results demonstrate the efficacy of the proposed technique, with better tracking performance and lower control energy compared to other strategies., Comment: 20 pages, 7 figures, 1 table
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- 2022
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214. A Fast Scale-Invariant Algorithm for Non-negative Least Squares with Non-negative Data
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Diakonikolas, Jelena, Li, Chenghui, Padmanabhan, Swati, and Song, Chaobing
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Mathematics - Optimization and Control ,Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Nonnegative (linear) least square problems are a fundamental class of problems that is well-studied in statistical learning and for which solvers have been implemented in many of the standard programming languages used within the machine learning community. The existing off-the-shelf solvers view the non-negativity constraint in these problems as an obstacle and, compared to unconstrained least squares, perform additional effort to address it. However, in many of the typical applications, the data itself is nonnegative as well, and we show that the nonnegativity in this case makes the problem easier. In particular, while the oracle complexity of unconstrained least squares problems necessarily scales with one of the data matrix constants (typically the spectral norm) and these problems are solved to additive error, we show that nonnegative least squares problems with nonnegative data are solvable to multiplicative error and with complexity that is independent of any matrix constants. The algorithm we introduce is accelerated and based on a primal-dual perspective. We further show how to provably obtain linear convergence using adaptive restart coupled with our method and demonstrate its effectiveness on large-scale data via numerical experiments.
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- 2022
215. Cold shock domain–containing protein E1 is a posttranscriptional regulator of the LDL receptor
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Smith, Geoffrey A, Padmanabhan, Arun, Lau, Bryan H, Pampana, Akhil, Li, Li, Lee, Clara Y, Pelonero, Angelo, Nishino, Tomohiro, Sadagopan, Nandhini, Xia, Vivian Q, Jain, Rajan, Natarajan, Pradeep, Wu, Roland S, Black, Brian L, Srivastava, Deepak, Shokat, Kevan M, and Chorba, John S
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Medical Biotechnology ,Biomedical and Clinical Sciences ,Atherosclerosis ,Heart Disease ,Digestive Diseases ,Heart Disease - Coronary Heart Disease ,Cardiovascular ,Genetics ,Biotechnology ,Aetiology ,2.1 Biological and endogenous factors ,Animals ,Cold-Shock Response ,DNA-Binding Proteins ,Humans ,Mice ,Proprotein Convertase 9 ,RNA ,Messenger ,RNA-Binding Proteins ,Receptors ,LDL ,Transcription ,Genetic ,Biological Sciences ,Medical and Health Sciences ,Medical biotechnology ,Biomedical engineering - Abstract
The low-density lipoprotein receptor (LDLR) controls cellular delivery of cholesterol and clears LDL from the bloodstream, protecting against atherosclerotic heart disease, the leading cause of death in the United States. We therefore sought to identify regulators of the LDLR beyond the targets of current therapies and known causes of familial hypercholesterolemia. We found that cold shock domain-containing protein E1 (CSDE1) enhanced hepatic LDLR messenger RNA (mRNA) decay via its 3' untranslated region and regulated atherogenic lipoproteins in vivo. Using parallel phenotypic genome-wide CRISPR interference screens in a tissue culture model, we identified 40 specific regulators of the LDLR that were not previously identified by observational human genetic studies. Among these, we demonstrated that, in HepG2 cells, CSDE1 regulated the LDLR at least as strongly as statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. In addition, we showed that hepatic gene silencing of Csde1 treated diet-induced dyslipidemia in mice to a similar degree as Pcsk9 silencing. These results suggest the therapeutic potential of targeting CSDE1 to manipulate the posttranscriptional regulation of the LDLR mRNA for the prevention of cardiovascular disease. Our approach of modeling a clinically relevant phenotype in a forward genetic screen, followed by mechanistic pharmacologic dissection and in vivo validation, may serve as a generalizable template for the identification of therapeutic targets in other human disease states.
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- 2022
216. Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors.
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Zhu, Lili, Gonzalez-Teran, Barbara, Ang, Yen-Sin, Thomas, Reuben, Stone, Nicole, Liu, Lei, Zhou, Ping, Zhu, Chenchen, Ruan, Hongmei, Huang, Yu, Jin, Shibo, Pelonero, Angelo, Koback, Frances, Padmanabhan, Arun, Sadagopan, Nandhini, Hsu, Austin, Costa, Mauro, Gifford, Casey, van Bemmel, Joke, Hüttenhain, Ruth, Conklin, Bruce, Black, Brian, Bruneau, Benoit, Steinmetz, Lars, Krogan, Nevan, Pollard, Katherine, Srivastava, Deepak, Vedantham, Vasanth, and Choudhary, Krishna
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GATA4 transcription factor ,RNA splicing ,RNA-binding motifs ,induced pluripotent stem cells ,myocytes ,cardiac ,Alternative Splicing ,Animals ,GATA4 Transcription Factor ,Heart ,Humans ,Induced Pluripotent Stem Cells ,Mice ,Myocytes ,Cardiac ,RNA - Abstract
BACKGROUND: GATA4 (GATA-binding protein 4), a zinc finger-containing, DNA-binding transcription factor, is essential for normal cardiac development and homeostasis in mice and humans, and mutations in this gene have been reported in human heart defects. Defects in alternative splicing are associated with many heart diseases, yet relatively little is known about how cell type- or cell state-specific alternative splicing is achieved in the heart. Here, we show that GATA4 regulates cell type-specific splicing through direct interaction with RNA and the spliceosome in human induced pluripotent stem cell-derived cardiac progenitors. METHODS: We leveraged a combination of unbiased approaches including affinity purification of GATA4 and mass spectrometry, enhanced cross-linking with immunoprecipitation, electrophoretic mobility shift assays, in vitro splicing assays, and unbiased transcriptomic analysis to uncover GATA4s novel function as a splicing regulator in human induced pluripotent stem cell-derived cardiac progenitors. RESULTS: We found that GATA4 interacts with many members of the spliceosome complex in human induced pluripotent stem cell-derived cardiac progenitors. Enhanced cross-linking with immunoprecipitation demonstrated that GATA4 also directly binds to a large number of mRNAs through defined RNA motifs in a sequence-specific manner. In vitro splicing assays indicated that GATA4 regulates alternative splicing through direct RNA binding, resulting in functionally distinct protein products. Correspondingly, knockdown of GATA4 in human induced pluripotent stem cell-derived cardiac progenitors resulted in differential alternative splicing of genes involved in cytoskeleton organization and calcium ion import, with functional consequences associated with the protein isoforms. CONCLUSIONS: This study shows that in addition to its well described transcriptional function, GATA4 interacts with members of the spliceosome complex and regulates cell type-specific alternative splicing via sequence-specific interactions with RNA. Several genes that have splicing regulated by GATA4 have functional consequences and many are associated with dilated cardiomyopathy, suggesting a novel role for GATA4 in achieving the necessary cardiac proteome in normal and stress-responsive conditions.
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- 2022
217. Simulating Network Paths with Recurrent Buffering Units
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Anshumaan, Divyam, Balasubramanian, Sriram, Tiwari, Shubham, Natarajan, Nagarajan, Sellamanickam, Sundararajan, and Padmanabhan, Venkata N.
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Computer Science - Networking and Internet Architecture ,Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Simulating physical network paths (e.g., Internet) is a cornerstone research problem in the emerging sub-field of AI-for-networking. We seek a model that generates end-to-end packet delay values in response to the time-varying load offered by a sender, which is typically a function of the previously output delays. The problem setting is unique, and renders the state-of-the-art text and time-series generative models inapplicable or ineffective. We formulate an ML problem at the intersection of dynamical systems, sequential decision making, and time-series modeling. We propose a novel grey-box approach to network simulation that embeds the semantics of physical network path in a new RNN-style model called RBU, providing the interpretability of standard network simulator tools, the power of neural models, the efficiency of SGD-based techniques for learning, and yielding promising results on synthetic and real-world network traces., Comment: Accepted in AAAI 2023, 19 pages, 14 figures
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- 2022
218. Redshift space distortions in Lagrangian space and the linear large scale velocity field of dark matter
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Tyhurst, Emily, Padmanabhan, Hamsa, and Pen, Ue-Li
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Untangling the connection between redshift space coordinates, a velocity measurement, and three dimensional real space coordinates, is a cosmological problem that is often modeled through a linear understanding of the velocity-position coupling. This linear information is better preserved in the Lagrangian space picture of the matter density field. Through Lagrangian space measurements, we can extract more information and make more accurate estimates of the linear growth rate of the universe. In this paper, we address the linear modelling of matter particle velocities through transfer functions, and in doing so examine to what degree the decrease in correlation with initial conditions may be contaminated by velocity-based nonlinearities. With a thorough analysis of the monopole-quadrupole ratio, we find the best-fit value for the Eulerian velocity dispersion, $\sigma_p = 378.3$ km/s. The covariance of the cosmological linear growth rate $f$, is estimated in the Eulerian and Lagrangian cases. Comparing Lagrangian and Eulerian, we find that the error in $f$ improves by a factor of 3, without the need for nonlinear velocity dispersion modelling., Comment: 7 pages, 7 figures
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- 2022
219. Signatures of supermassive black hole binaries on maser systems
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Padmanabhan, Hamsa and Loeb, Abraham
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We illustrate a novel signature of black hole binaries from their effect on the kinematics of water maser emission in their environments. With the help of simulations, we establish the condition for clumps to mase based on their coherence lengths calibrated to those of the known maser galaxy NGC 4258. This is then used to identify masing clumps around a binary black hole system, and quantify the kinematic and spectral differences relative to the single black hole case. For some generic circumstances, blue-shifted masers around a binary black hole are found to preferentially follow the Keplerian rotation curve observed in the single black hole case. The redshifted ones, however, are found to visibly deviate from this relation, and also display more scatter with a tendency towards lower absolute values of the velocity along the line-of-sight. The spectrum of the masers as a function of line-of-sight velocity also shows a double peaked structure, reminiscent of recent observations of systems such as Mrk 1. Our results motivate future prospects for identifying binary black hole candidates with the help of water maser emissions., Comment: 6 pages, 11 figures; accepted for publication in MNRAS
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- 2022
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220. Leveraging Bitstream Metadata for Fast, Accurate, Generalized Compressed Video Quality Enhancement
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Ehrlich, Max, Barker, Jon, Padmanabhan, Namitha, Davis, Larry, Tao, Andrew, Catanzaro, Bryan, and Shrivastava, Abhinav
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Video compression is a central feature of the modern internet powering technologies from social media to video conferencing. While video compression continues to mature, for many compression settings, quality loss is still noticeable. These settings nevertheless have important applications to the efficient transmission of videos over bandwidth constrained or otherwise unstable connections. In this work, we develop a deep learning architecture capable of restoring detail to compressed videos which leverages the underlying structure and motion information embedded in the video bitstream. We show that this improves restoration accuracy compared to prior compression correction methods and is competitive when compared with recent deep-learning-based video compression methods on rate-distortion while achieving higher throughput. Furthermore, we condition our model on quantization data which is readily available in the bitstream. This allows our single model to handle a variety of different compression quality settings which required an ensemble of models in prior work., Comment: WACV 2024
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- 2022
221. GEMEL: Model Merging for Memory-Efficient, Real-Time Video Analytics at the Edge
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Padmanabhan, Arthi, Agarwal, Neil, Iyer, Anand, Ananthanarayanan, Ganesh, Shu, Yuanchao, Karianakis, Nikolaos, Xu, Guoqing Harry, and Netravali, Ravi
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Computer Science - Distributed, Parallel, and Cluster Computing ,Computer Science - Artificial Intelligence - Abstract
Video analytics pipelines have steadily shifted to edge deployments to reduce bandwidth overheads and privacy violations, but in doing so, face an ever-growing resource tension. Most notably, edge-box GPUs lack the memory needed to concurrently house the growing number of (increasingly complex) models for real-time inference. Unfortunately, existing solutions that rely on time/space sharing of GPU resources are insufficient as the required swapping delays result in unacceptable frame drops and accuracy violations. We present model merging, a new memory management technique that exploits architectural similarities between edge vision models by judiciously sharing their layers (including weights) to reduce workload memory costs and swapping delays. Our system, GEMEL, efficiently integrates merging into existing pipelines by (1) leveraging several guiding observations about per-model memory usage and inter-layer dependencies to quickly identify fruitful and accuracy-preserving merging configurations, and (2) altering edge inference schedules to maximize merging benefits. Experiments across diverse workloads reveal that GEMEL reduces memory usage by up to 60.7%, and improves overall accuracy by 8-39% relative to time/space sharing alone.
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- 2022
222. Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells
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Padmanabhan, Jagannath, Chen, Kellen, Sivaraj, Dharshan, Henn, Dominic, Kuehlmann, Britta A., Kussie, Hudson C., Zhao, Eric T., Kahn, Anum, Bonham, Clark A., Dohi, Teruyuki, Beck, Thomas C., Trotsyuk, Artem A., Stern-Buchbinder, Zachary A., Than, Peter A., Hosseini, Hadi S., Barrera, Janos A., Magbual, Noah J., Leeolou, Melissa C., Fischer, Katharina S., Tigchelaar, Seth S., Lin, John Q., Perrault, David P., Borrelli, Mimi R., Kwon, Sun Hyung, Maan, Zeshaan N., Dunn, James C. Y., Nazerali, Rahim, Januszyk, Michael, Prantl, Lukas, and Gurtner, Geoffrey C.
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- 2023
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223. Experimental studies on liquefaction and reliquefaction potential of saturated ground subjected to repeated incremental acceleration loading with varying shaking duration
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Padmanabhan, Gowtham and Shanmugam, Ganesh Kumar
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- 2023
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224. On the Role of Semi-Die Angle in Multi-Pass Cyclic Expansion Extrusion: Effects on Microstructure and Mechanical Properties of AA 6063
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Babu, V., Shanmugavel, Balasivanandha Prabu, and Padmanabhan, K. A.
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- 2023
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225. Effect of green pea pod lignin addition on thermal degradation, flame resistance, DMA, and creep resistance of pineapple fibre epoxy composite
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Giridharan, K., Sasirekha, S., Padmanabhan, S., Chakravarthi, G., and Stalin, B.
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- 2023
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226. Hegelian Legacy of Aesthetics: Theory of Art Versus Philosophy of Art
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Padmanabhan, Sudarsan
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- 2023
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227. Small Round Blue Cell Tumours of the Sinonasal Area: Our 5 year Experience in a Tertiary Care Centre in India
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Reddy Y, Mounika, Padmanabhan, Sourabh, Babu A, Shobhan, Swarna B, Sai, and Nagaraju
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- 2023
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228. Pollution to Product—a Novel Two-Stage Single-Pot Fermentative Production of 1,3-Propanediol
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Anand, Shreya, Mukherjee, Koel, and Padmanabhan, Padmini
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- 2023
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229. Non-CSS color codes on 2D lattices : Models and Topological Properties
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Padmanabhan, Pramod, Chowdhury, Abhishek, Sugino, Fumihiko, Majumdar, Mrittunjoy Guha, and Sabapathy, Krishna Kumar
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Quantum Physics ,Condensed Matter - Strongly Correlated Electrons ,High Energy Physics - Theory - Abstract
The two-dimensional color code is an alternative to the toric code that encodes more logical qubits while maintaining crucial features of the $\mathbb{Z}_2\times\mathbb{Z}_2$ toric code in the long wavelength limit. However its short range physics include single qubit Pauli operations that violate either three or six stabilisers as opposed to the toric code where single qubit Pauli operations violate two or four stabilisers. Exploiting this fact we construct several non-CSS versions of the two-dimensional color code falling into two families - those where either three, four or five stabilisers are violated and those which violate exactly four stabilisers for all the three types of single qubit Pauli operations. These models are not equivalent to the original color code by a local unitary transformation. Nevertheless the code spaces of the CSS and non-CSS versions are related by local unitaries which reflects the fact that their long range physics coincide. This also implies that the non-CSS versions host transversal Clifford gates and hence support fault-tolerant computations. As a consequence of the non-CSS structure, the logical operators are of a mixed type which in some cases include all the three Pauli operators making them potentially useful for protection against biased Pauli noise., Comment: v1 - 58 pages, 100 figures; v2 - Minor changes in Introduction and in Preliminaries section. More references added, 59 pages
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- 2021
230. Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and Therapeutics
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Desikan, Rajat, Padmanabhan, Pranesh, Kierzek, Andrzej M., and van der Graaf, Piet H.
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Quantitative Biology - Populations and Evolution - Abstract
The COVID-19 pandemic has severely impacted health systems and economies worldwide. Significant global efforts are therefore ongoing to improve vaccine efficacies, optimize vaccine deployment, and develop new antiviral therapies to combat the pandemic. Mechanistic viral dynamics and quantitative systems pharmacology models of SARS-CoV-2 infection, vaccines, immunomodulatory agents, and antiviral therapeutics have played a key role in advancing our understanding of SARS-CoV-2 pathogenesis and transmission, the interplay between innate and adaptive immunity to influence the outcomes of infection, effectiveness of treatments, mechanisms and performance of COVID-19 vaccines, and the impact of emerging SARS-CoV-2 variants. Here, we review some of the critical insights provided by these models and discuss the challenges ahead., Comment: Mini-review, 2 figures
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- 2021
231. Microscopic origin of Einstein's field equations and the raison d'\^{e}tre for a positive cosmological constant
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Padmanabhan, T. and Chakraborty, Sumanta
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General Relativity and Quantum Cosmology ,Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Theory - Abstract
In the paradigm of effective field theory, one hierarchically obtains the effective action $\mathcal{A}_{\rm eff}[q, \cdots]$ for some low(er) energy degrees of freedom $q$, by integrating out the high(er) energy degrees of freedom $\xi$, in a path integral, based on an action $\mathcal{A}[q,\xi, \cdots]$. We show how one can integrate out a vector field $v^a$ in an action $\mathcal{A}[\Gamma,v,\cdots ]$ and obtain an effective action $\mathcal{A}_{\rm eff}[\Gamma, \cdots]$ which, on variation with respect to the connection $\Gamma$, leads to the Einstein's field equations and a metric compatible with the connection. The derivation \textit{predicts} a non-zero, positive, \cc, which arises as an integration constant. The Euclidean action $\mathcal{A}[\Gamma,v, \cdots]$, has an interpretation as the heat density of null surfaces, when translated into the Lorentzian spacetime. The vector field $v^a$ can be interpreted as the Euclidean analogue of the microscopic degrees of freedom hosted by any null surface. Several implications of this approach are discussed., Comment: Published Version; 12 pages; Prof. T. Padmanabhan has passed away on 17th September, 2021, while this paper was under review in a journal
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- 2021
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232. Decomposing the Deep: Finding Class Specific Filters in Deep CNNs
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Badola, Akshay, Roy, Cherian, Padmanabhan, Vineet, and Lal, Rajendra
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Interpretability of Deep Neural Networks has become a major area of exploration. Although these networks have achieved state of the art accuracy in many tasks, it is extremely difficult to interpret and explain their decisions. In this work we analyze the final and penultimate layers of Deep Convolutional Networks and provide an efficient method for identifying subsets of features that contribute most towards the network's decision for a class. We demonstrate that the number of such features per class is much lower in comparison to the dimension of the final layer and therefore the decision surface of Deep CNNs lies on a low dimensional manifold and is proportional to the network depth. Our methods allow to decompose the final layer into separate subspaces which is far more interpretable and has a lower computational cost as compared to the final layer of the full network., Comment: 22 pages, 5 figures, 8 tables. github repo: https://github.com/akshaybadola/cnn-class-specific-filters-with-histogram. Preprint submitted to Elsevier. This version contains visualization of filters and ablation study w.r.t. influential features
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- 2021
233. A gradient sampling method with complexity guarantees for Lipschitz functions in high and low dimensions
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Davis, Damek, Drusvyatskiy, Dmitriy, Lee, Yin Tat, Padmanabhan, Swati, and Ye, Guanghao
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Mathematics - Optimization and Control ,65K05, 65K10, 90C15, 90C30 - Abstract
Zhang et al. introduced a novel modification of Goldstein's classical subgradient method, with an efficiency guarantee of $O(\varepsilon^{-4})$ for minimizing Lipschitz functions. Their work, however, makes use of a nonstandard subgradient oracle model and requires the function to be directionally differentiable. In this paper, we show that both of these assumptions can be dropped by simply adding a small random perturbation in each step of their algorithm. The resulting method works on any Lipschitz function whose value and gradient can be evaluated at points of differentiability. We additionally present a new cutting plane algorithm that achieves better efficiency in low dimensions: $O(d\varepsilon^{-3})$ for Lipschitz functions and $O(d\varepsilon^{-2})$ for those that are weakly convex., Comment: 14 pages
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- 2021
234. Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapy
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Götz, Jürgen and Padmanabhan, Pranesh
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- 2024
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235. Targeting transcription in heart failure via CDK7/12/13 inhibition
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Hsu, Austin, Duan, Qiming, Day, Daniel S, Luo, Xin, McMahon, Sarah, Huang, Yu, Feldman, Zachary B, Jiang, Zhen, Zhang, Tinghu, Liang, Yanke, Alexanian, Michael, Padmanabhan, Arun, Brown, Jonathan D, Lin, Charles Y, Gray, Nathanael S, Young, Richard A, Bruneau, Benoit G, and Haldar, Saptarsi M
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Medical Physiology ,Biomedical and Clinical Sciences ,Biotechnology ,Heart Disease ,Genetics ,Cardiovascular ,2.1 Biological and endogenous factors ,Aetiology ,Animals ,Cell Line ,Tumor ,Cyclin-Dependent Kinases ,Heart Failure ,Humans ,Mice ,RNA Polymerase II ,Stroke Volume - Abstract
Heart failure with reduced ejection fraction (HFrEF) is associated with high mortality, highlighting an urgent need for new therapeutic strategies. As stress-activated cardiac signaling cascades converge on the nucleus to drive maladaptive gene programs, interdicting pathological transcription is a conceptually attractive approach for HFrEF therapy. Here, we demonstrate that CDK7/12/13 are critical regulators of transcription activation in the heart that can be pharmacologically inhibited to improve HFrEF. CDK7/12/13 inhibition using the first-in-class inhibitor THZ1 or RNAi blocks stress-induced transcription and pathologic hypertrophy in cultured rodent cardiomyocytes. THZ1 potently attenuates adverse cardiac remodeling and HFrEF pathogenesis in mice and blocks cardinal features of disease in human iPSC-derived cardiomyocytes. THZ1 suppresses Pol II enrichment at stress-transactivated cardiac genes and inhibits a specific pathologic gene program in the failing mouse heart. These data identify CDK7/12/13 as druggable regulators of cardiac gene transactivation during disease-related stress, suggesting that HFrEF features a critical dependency on transcription that can be therapeutically exploited.
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- 2022
236. Young Mathematicians Take Action through Sport Clinics
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Jennifer Suh, Gretchen Maxwell, Kate Roscioli, Holly Tate, Padmanabhan Seshaiyer, and Risto Marttinen
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A powerful way to build students' mathematical power and agency is through Teaching Mathematics for Social Justice (TMfSJ), where students read and write the world with mathematics (Gutstein, 2005). Reading the world with mathematics uses mathematics to understand relations of power, resource inequities, and disparate opportunities between different social groups and to understand explicit discrimination based on race, class, gender, language, and other differences, while writing the world with mathematics involves taking action (Gutstein & Peterson, 2013). In this article, the authors share one teacher's story of how she used her students' interests to uncover reasons for the economic inequalities and fair access to sports at their local high school.
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- 2023
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237. Health Monitoring of Industrial machines using Scene-Aware Threshold Selection
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Singh, Arshdeep, Arvind, Raju, and Rajan, Padmanabhan
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Computer Science - Sound ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Audio and Speech Processing ,Electrical Engineering and Systems Science - Signal Processing - Abstract
This paper presents an autoencoder based unsupervised approach to identify anomaly in an industrial machine using sounds produced by the machine. The proposed framework is trained using log-melspectrogram representations of the sound signal. In classification, our hypothesis is that the reconstruction error computed for an abnormal machine is larger than that of the a normal machine, since only normal machine sounds are being used to train the autoencoder. A threshold is chosen to discriminate between normal and abnormal machines. However, the threshold changes as surrounding conditions vary. To select an appropriate threshold irrespective of the surrounding, we propose a scene classification framework, which can classify the underlying surrounding. Hence, the threshold can be selected adaptively irrespective of the surrounding. The experiment evaluation is performed on MIMII dataset for industrial machines namely fan, pump, valve and slide rail. Our experiment analysis shows that utilizing adaptive threshold, the performance improves significantly as that obtained using the fixed threshold computed for a given surrounding only., Comment: 5 pages, 4 figures, 1 Table
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- 2021
238. COMAP Early Science: VII. Prospects for CO Intensity Mapping at Reionization
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Breysse, Patrick C., Chung, Dongwoo T., Cleary, Kieran A., Ihle, Håvard T., Padmanabhan, Hamsa, Silva, Marta B., Bond, J. Richard, Borowska, Jowita, Catha, Morgan, Church, Sarah E., Dunne, Delaney A., Eriksen, Hans Kristian, Foss, Marie Kristine, Gaier, Todd, Gundersen, Joshua Ott, Harris, Andrew I., Hobbs, Richard, Keating, Laura, Lamb, James W., Lawrence, Charles R., Lunde, Jonas G. S., Murray, Norman, Pearson, Timothy J., Philip, Liju, Rasmussen, Maren, Readhead, Anthony C. S., Rennie, Thomas J., Stutzer, Nils-Ole, Viero, Marco P., Watts, Duncan J., Wehus, Ingunn Katherine, and Woody, David P.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We introduce COMAP-EoR, the next generation of the Carbon Monoxide Mapping Array Project aimed at extending CO intensity mapping to the Epoch of Reionization. COMAP-EoR supplements the existing 30 GHz COMAP Pathfinder with two additional 30 GHz instruments and a new 16 GHz receiver. This combination of frequencies will be able to simultaneously map CO(1--0) and CO(2--1) at reionization redshifts ($z\sim5-8$) in addition to providing a significant boost to the $z\sim3$ sensitivity of the Pathfinder. We examine a set of existing models of the EoR CO signal, and find power spectra spanning several orders of magnitude, highlighting our extreme ignorance about this period of cosmic history and the value of the COMAP-EoR measurement. We carry out the most detailed forecast to date of an intensity mapping cross-correlation, and find that five out of the six models we consider yield signal to noise ratios (S/N) $\gtrsim20$ for COMAP-EoR, with the brightest reaching a S/N above 400. We show that, for these models, COMAP-EoR can make a detailed measurement of the cosmic molecular gas history from $z\sim2-8$, as well as probe the population of faint, star-forming galaxies predicted by these models to be undetectable by traditional surveys. We show that, for the single model that does not predict numerous faint emitters, a COMAP-EoR-type measurement is required to rule out their existence. We briefly explore prospects for a third-generation Expanded Reionization Array (COMAP-ERA) capable of detecting the faintest models and characterizing the brightest signals in extreme detail., Comment: Paper 7 of 7 in series. 19 pages, 10 figures, to be submitted to ApJ
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- 2021
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239. COMAP Early Science: V. Constraints and Forecasts at $z \sim 3$
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Chung, Dongwoo T., Breysse, Patrick C., Cleary, Kieran A., Ihle, Håvard T., Padmanabhan, Hamsa, Silva, Marta B., Bond, J. Richard, Borowska, Jowita, Catha, Morgan, Church, Sarah E., Dunne, Delaney A., Eriksen, Hans Kristian, Foss, Marie Kristine, Gaier, Todd, Gundersen, Joshua Ott, Harper, Stuart E., Harris, Andrew I., Hensley, Brandon, Hobbs, Richard, Keating, Laura C., Kim, Junhan, Lamb, James W., Lawrence, Charles R., Lunde, Jonas Gahr Sturtzel, Murray, Norman, Pearson, Timothy J., Philip, Liju, Rasmussen, Maren, Readhead, Anthony C. S., Rennie, Thomas J., Stutzer, Nils-Ole, Uzgil, Bade D., Viero, Marco P., Watts, Duncan J., Wechsler, Risa H., Wehus, Ingunn Kathrine, and Woody, David P.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present the current state of models for the $z\sim3$ carbon monoxide (CO) line-intensity signal targeted by the CO Mapping Array Project (COMAP) Pathfinder in the context of its early science results. Our fiducial model, relating dark matter halo properties to CO luminosities, informs parameter priors with empirical models of the galaxy-halo connection and previous CO(1-0) observations. The Pathfinder early science data spanning wavenumbers $k=0.051$-$0.62\,$Mpc$^{-1}$ represent the first direct 3D constraint on the clustering component of the CO(1-0) power spectrum. Our 95% upper limit on the redshift-space clustering amplitude $A_{\rm clust}\lesssim70\,\mu$K$^2$ greatly improves on the indirect upper limit of $420\,\mu$K$^2$ reported from the CO Power Spectrum Survey (COPSS) measurement at $k\sim1\,$Mpc$^{-1}$. The COMAP limit excludes a subset of models from previous literature, and constrains interpretation of the COPSS results, demonstrating the complementary nature of COMAP and interferometric CO surveys. Using line bias expectations from our priors, we also constrain the squared mean line intensity-bias product, $\langle{Tb}\rangle^2\lesssim50\,\mu$K$^2$, and the cosmic molecular gas density, $\rho_\text{H2}<2.5\times10^8\,M_\odot\,$Mpc$^{-3}$ (95% upper limits). Based on early instrument performance and our current CO signal estimates, we forecast that the five-year Pathfinder campaign will detect the CO power spectrum with overall signal-to-noise of 9-17. Between then and now, we also expect to detect the CO-galaxy cross-spectrum using overlapping galaxy survey data, enabling enhanced inferences of cosmic star-formation and galaxy-evolution history., Comment: Paper 5 of 7 in series. 17 pages + appendix and bibliography (30 pages total); 15 figures, 6 tables; accepted for publication in ApJ; v3 reflects the accepted version with minor changes and additions to text
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- 2021
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240. COMAP Early Science: IV. Power Spectrum Methodology and Results
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Ihle, Håvard T., Borowska, Jowita, Cleary, Kieran A., Eriksen, Hans Kristian, Foss, Marie K., Harper, Stuart E., Kim, Junhan, Lunde, Jonas G. S., Philip, Liju, Rasmussen, Maren, Stutzer, Nils-Ole, Uzgil, Bade D., Watts, Duncan J., Wehus, Ingunn Kathrine, Bond, J. Richard, Breysse, Patrick C., Catha, Morgan, Church, Sarah E., Chung, Dongwoo T., Dickinson, Clive, Dunne, Delaney A., Gaier, Todd, Gundersen, Joshua Ott, Harris, Andrew I., Hobbs, Richard, Lamb, James W., Lawrence, Charles R., Murray, Norman, Readhead, Anthony C. S., Padmanabhan, Hamsa, Pearson, Timothy J., Rennie, Thomas J., and Woody, David P.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present the power spectrum methodology used for the first-season COMAP analysis, and assess the quality of the current data set. The main results are derived through the Feed-feed Pseudo-Cross-Spectrum (FPXS) method, which is a robust estimator with respect to both noise modeling errors and experimental systematics. We use effective transfer functions to take into account the effects of instrumental beam smoothing and various filter operations applied during the low-level data processing. The power spectra estimated in this way have allowed us to identify a systematic error associated with one of our two scanning strategies, believed to be due to residual ground or atmospheric contamination. We omit these data from our analysis and no longer use this scanning technique for observations. We present the power spectra from our first season of observing and demonstrate that the uncertainties are integrating as expected for uncorrelated noise, with any residual systematics suppressed to a level below the noise. Using the FPXS method, and combining data on scales $k=0.051-0.62 \,\mathrm{Mpc}^{-1}$ we estimate $P_\mathrm{CO}(k) = -2.7 \pm 1.7 \times 10^4\mu\textrm{K}^2\mathrm{Mpc}^3$, the first direct 3D constraint on the clustering component of the CO(1-0) power spectrum in the literature., Comment: Paper 4 of 7 in series. 18 pages, 11 figures, as accepted in ApJ
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- 2021
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241. COMAP Early Science: III. CO Data Processing
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Foss, Marie K., Ihle, Håvard T., Borowska, Jowita, Cleary, Kieran A., Eriksen, Hans Kristian, Harper, Stuart E., Kim, Junhan, Lamb, James W., Lunde, Jonas G. S., Philip, Liju, Rasmussen, Maren, Stutzer, Nils-Ole, Uzgil, Bade D., Watts, Duncan J., Wehus, Ingunn K., Woody, David P., Bond, J. Richard, Breysse, Patrick C., Catha, Morgan, Church, Sarah E., Chung, Dongwoo T., Dickinson, Clive, Dunne, Delaney A., Gaier, Todd, Gundersen, Joshua Ott, Harris, Andrew I., Hobbs, Richard, Lawrence, Charles R., Murray, Norman, Readhead, Anthony C. S., Padmanabhan, Hamsa, Pearson, Timothy J., and Rennie, Thomas J.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We describe the first season COMAP analysis pipeline that converts raw detector readouts to calibrated sky maps. This pipeline implements four main steps: gain calibration, filtering, data selection, and map-making. Absolute gain calibration relies on a combination of instrumental and astrophysical sources, while relative gain calibration exploits real-time total-power variations. High efficiency filtering is achieved through spectroscopic common-mode rejection within and across receivers, resulting in nearly uncorrelated white noise within single-frequency channels. Consequently, near-optimal but biased maps are produced by binning the filtered time stream into pixelized maps; the corresponding signal bias transfer function is estimated through simulations. Data selection is performed automatically through a series of goodness-of-fit statistics, including $\chi^2$ and multi-scale correlation tests. Applying this pipeline to the first-season COMAP data, we produce a dataset with very low levels of correlated noise. We find that one of our two scanning strategies (the Lissajous type) is sensitive to residual instrumental systematics. As a result, we no longer use this type of scan and exclude data taken this way from our Season 1 power spectrum estimates. We perform a careful analysis of our data processing and observing efficiencies and take account of planned improvements to estimate our future performance. Power spectrum results derived from the first-season COMAP maps are presented and discussed in companion papers., Comment: Paper 3 of 7 in series. 26 pages, 23 figures, submitted to ApJ
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- 2021
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242. COMAP Early Science: I. Overview
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Cleary, Kieran A., Borowska, Jowita, Breysse, Patrick C., Catha, Morgan, Chung, Dongwoo T., Church, Sarah E., Dickinson, Clive, Eriksen, Hans Kristian, Foss, Marie Kristine, Gundersen, Joshua Ott, Harper, Stuart E., Harris, Andrew I., Hobbs, Richard, Håvard, Ihle, T., Kim, Junhan, Kocz, Jonathon, Lamb, James W., Lunde, Jonas G. S., Padmanabhan, Hamsa, Pearson, Timothy J., Philip, Liju, Powell, Travis W., Rasmussen, Maren, Readhead, Anthony C. S., Rennie, Thomas J., Silva, Marta B., Stutzer, Nils-Ole, Uzgil, Bade D., Watts, Duncan J., Wehus, Ingunn Kathrine, Woody, David P., Basoalto, Lilian, Bond, J. Richard, Dunne, Delaney A., Gaier, Todd, Hensley, Brandon, Keating, Laura C., Lawrence, Charles R., Murray, Norman, Reeves, Rodrigo, Viero, Marco P., and Wechsler, Risa
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
The CO Mapping Array Project (COMAP) aims to use line intensity mapping of carbon monoxide (CO) to trace the distribution and global properties of galaxies over cosmic time, back to the Epoch of Reionization (EoR). To validate the technologies and techniques needed for this goal, a Pathfinder instrument has been constructed and fielded. Sensitive to CO(1-0) emission from $z=2.4$-$3.4$ and a fainter contribution from CO(2-1) at $z=6$-8, the Pathfinder is surveying $12$ deg$^2$ in a 5-year observing campaign to detect the CO signal from $z\sim3$. Using data from the first 13 months of observing, we estimate $P_\mathrm{CO}(k) = -2.7 \pm 1.7 \times 10^4\mu\mathrm{K}^2 \mathrm{Mpc}^3$ on scales $k=0.051-0.62 \mathrm{Mpc}^{-1}$ - the first direct 3D constraint on the clustering component of the CO(1-0) power spectrum. Based on these observations alone, we obtain a constraint on the amplitude of the clustering component (the squared mean CO line temperature-bias product) of $\langle Tb\rangle^2<49$ $\mu$K$^2$ - nearly an order-of-magnitude improvement on the previous best measurement. These constraints allow us to rule out two models from the literature. We forecast a detection of the power spectrum after 5 years with signal-to-noise ratio (S/N) 9-17. Cross-correlation with an overlapping galaxy survey will yield a detection of the CO-galaxy power spectrum with S/N of 19. We are also conducting a 30 GHz survey of the Galactic plane and present a preliminary map. Looking to the future of COMAP, we examine the prospects for future phases of the experiment to detect and characterize the CO signal from the EoR., Comment: Paper 1 of 7 in series. 18 pages, 16 figures, submitted to ApJ
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- 2021
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243. COMAP Early Science: II. Pathfinder Instrument
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Lamb, James W., Cleary, Kieran A., Woody, David P., Catha, Morgan, Chung, Dongwoo T., Gundersen, Joshua Ott, Harper, Stuart E., Harris, Andrew I., Hobbs, Richard, Ihle, Håvard T., Kocz, Jonathon, Pearson, Timothy J., Philip, Liju, Powell, Travis W., Basoalto, Lilian, Bond, J. Richard, Borowska, Jowita, Breysse, Patrick C., Church, Sarah E., Dickinson, Clive, Dunne, Delaney A., Eriksen, Hans Kristian, Foss, Marie Kristine, Gaier, Todd, Kim, Junhan, Lawrence, Charles R., Lunde, Jonas G. S., Padmanabhan, Hamsa, Rasmussen, Maren, Readhead, Anthony C. S., Reeves, Rodrigo, Rennie, Thomas J., Stutzer, Nils-Ole, Watts, Duncan J., and Wehus, Ingunn Kathrine
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
Line intensity mapping (LIM) is a new technique for tracing the global properties of galaxies over cosmic time. Detection of the very faint signals from redshifted carbon monoxide (CO), a tracer of star formation, pushes the limits of what is feasible with a total-power instrument. The CO Mapping Project (COMAP) Pathfinder is a first-generation instrument aiming to prove the concept and develop the technology for future experiments, as well as delivering early science products. With 19 receiver channels in a hexagonal focal plane arrangement on a 10.4 m antenna, and an instantaneous 26-34 GHz frequency range with 2 MHz resolution, it is ideally suited to measuring CO($J$=1-0) from $z\sim3$. In this paper we discuss strategies for designing and building the Pathfinder and the challenges that were encountered. The design of the instrument prioritized LIM requirements over those of ancillary science. After a couple of years of operation, the instrument is well understood, and the first year of data is already yielding useful science results. Experience with this Pathfinder will drive the design of the next generations of experiments., Comment: Paper 2 of 7 in series. 27 pages, 28 figures, submitted to ApJ
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- 2021
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244. Synergies between the COMAP CO Line Intensity Mapping mission and a Ly{\alpha} galaxy survey: How to probe the early universe with voxel based analysis of observational data
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Silva, Marta B., Baumschlager, Bernhard, Cleary, Kieran A., Breysse, Patrick C., Chung, Dongwoo T., Ihle, Håvard T., Padmanabhan, Hamsa, Keating, Laura C., Kim, Junhan, and Philip, Liju
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Astrophysics - Astrophysics of Galaxies - Abstract
Line Intensity Mapping (LIM) offers a novel avenue to observe and characterize our universe. LIM data of CO spectral lines are becoming available, such as those obtained by the CO Mapping Array Project (COMAP). COMAP data can be used to probe the molecular gas content of the universe from the last stages of the Epoch of Reionization (EoR) ($z < 8.0$) to $z \sim 2.5$. In this work, we examine the prospects for deriving voxel-level statistical constraints on high-redshift galaxies from COMAP data by considering the additional information available from observations of LAEs galaxies using the Visible Integral-Field Replicable Unit Spectrograph (VIRUS) on the Hobby-Eberly Telescope (HET). We post-process the IllustrisTNG300 galaxy-formation simulation with a set of prescriptions to consistently determine CO and Ly$\alpha$ line luminosities. The different line prescriptions span the uncertainty in the CO line luminosity according to current observations by the VLA high-z CO surveys and set the Ly$\alpha$ emission to be compatible with observational LAE luminosity functions. We produce mock observations for the two surveys over a $(300\, {\rm Mpc})^3$ volume. These are then used to formulate and test methodologies for data analysis and to predict COMAP constraints on CO emission. We use combinations of masking, stacking, voxel intensity distribution (VID), and other statistics. We find that in combination with VIRUS/HET, a voxel-level analysis of the COMAP Pathfinder survey can detect and characterize the CO signal from $z\sim3$ and improve current constraints on the $z\sim6$ signal, identify individual voxels with bright CO(1-0) emission at $z\sim3$ and probe the redshift evolution of the CO emission. This study illustrates the potential of synergies between LIM and galaxy surveys both to improve the significance of a detection and to aid the interpretation of noisy LIM data., Comment: 15 pages, 9 figures, Submitted to Astronomy & Astrophysics
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- 2021
245. Computing Lewis Weights to High Precision
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Fazel, Maryam, Lee, Yin Tat, Padmanabhan, Swati, and Sidford, Aaron
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Computer Science - Data Structures and Algorithms ,Mathematics - Optimization and Control - Abstract
We present an algorithm for computing approximate $\ell_p$ Lewis weights to high precision. Given a full-rank $\mathbf{A} \in \mathbb{R}^{m \times n}$ with $m \geq n$ and a scalar $p>2$, our algorithm computes $\epsilon$-approximate $\ell_p$ Lewis weights of $\mathbf{A}$ in $\widetilde{O}_p(\log(1/\epsilon))$ iterations; the cost of each iteration is linear in the input size plus the cost of computing the leverage scores of $\mathbf{D}\mathbf{A}$ for diagonal $\mathbf{D} \in \mathbb{R}^{m \times m}$. Prior to our work, such a computational complexity was known only for $p \in (0, 4)$ [CohenPeng2015], and combined with this result, our work yields the first polylogarithmic-depth polynomial-work algorithm for the problem of computing $\ell_p$ Lewis weights to high precision for all constant $p > 0$. An important consequence of this result is also the first polylogarithmic-depth polynomial-work algorithm for computing a nearly optimal self-concordant barrier for a polytope., Comment: 24 pages
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- 2021
246. Thermal nature of a generic null surface
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Dalui, Surojit, Majhi, Bibhas Ranjan, and Padmanabhan, T.
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory ,Quantum Physics - Abstract
Dynamical properties of a generic null surface are known to have a thermodynamic interpretation. Such an interpretation is completely based on an analogy between the usual law of thermodynamics and structure of gravitational field equation on the surface. Here we materialise this analogy and show that assigning a temperature on the null surface for a local observer is indeed physically relevant. We find that for a local frame, chosen as outgoing massless chargeless particle (or field mode), perceives a "{\it local unstable Hamiltonian}" very near to the surface. Due to this it has finite quantum probability to escape through acausal null path which is given by Maxwell-Boltzmann like distribution, thereby providing a temperature on the surface., Comment: Minor modifications. This work is a tribute to Prof. T. Padmanabhan (1957-2021), a co-author of this paper, and it carries the fond memory of our last collaboration with him. To appear in Phys. Rev. D
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- 2021
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247. Complex interplay of magnetic ordering and spin-lattice coupling in orthochromite Nd$_{0.5}$Dy$_{0.5}$CrO$_{3}$
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Anas, M., Balasubramanian, Padmanabhan, Vikram, K., Singh, Ankita, Kumar, C. M. N., Hoser, Andreas, Rusinek, Dariusz, Sinha, A. K., Srihari, V., Singh, Ranjan K., Kumar, Rinku, Gupta, Mukul, Maitra, T., and Malik, V. K.
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Condensed Matter - Strongly Correlated Electrons - Abstract
The mixed rare-earth orthochromite Nd$_{0.5}$Dy$_{0.5}$CrO$_{3}$ has a N\'eel temperature ($T_\mathrm{{N}}$) of ${\sim}$ 175\,K, resulting in the G-type antiferromagnetic ordering of Cr$^{3+}$ spins. The inverse susceptibility shows a deviation from Curie-Weiss law at 230\,K, with a large effective paramagnetic moment of 8.8\,${\mu}_{\mathrm{B}}$. The ZFC-FC magnetization bifurcate just above $T_\mathrm{{N}}$ and show a distinct signature of spin reorientation near 60\,K. Neutron diffraction show that below $T_\mathrm{{N}}$, the Cr$^{3+}$ spins align in ${\Gamma}_{2}$ representation as ($F_{x}$, $G_{z}$). Below 60\,K, due to spin reorientation, the magnetic structure is in ${\Gamma}_{1}$ ($G_{y}$) configuration. The neutron diffraction does not show any signature of rare-earth ordering even at 1.5\,K. First principles density functional theory calculations within GGA+U and GGA+U+SO approximations reveal that the G-type antiferromagnetic order is the ground state magnetic structure of Cr sublattice and the spin-reorientation of Cr$^{3+}$ spins can happen in the absence of 3d-4f interactions unlike in the case of orthoferrites. The specific heat shows a `${\lambda}$' anomaly at $T_\mathrm{{N}}$, while at low temperature two distinct Schottky anomalies are observed; a Schottky peak at 2\,K and an additional step-like feature above 10\,K. Above $T_\mathrm{{N}}$, the magnetic transition is preceded by structural anomalies as seen in our x-ray diffraction and Raman measurements. The deviation of structural parameters near N\'eel temperature is smaller. The phonon frequencies show deviation from the standard anharmonic behaviour: first near 250\,K, due to magneto-volume effects while the second deviation occurs near 200\,K due to spin-phonon coupling., Comment: 12 pages, 13 figures
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- 2021
248. Data-driven approaches for predicting spread of infectious diseases through DINNs: Disease Informed Neural Networks
- Author
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Shaier, Sagi, Raissi, Maziar, and Seshaiyer, Padmanabhan
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Computer Science - Machine Learning ,Quantitative Biology - Quantitative Methods - Abstract
In this work, we present an approach called Disease Informed Neural Networks (DINNs) that can be employed to effectively predict the spread of infectious diseases. This approach builds on a successful physics informed neural network approaches that have been applied to a variety of applications that can be modeled by linear and non-linear ordinary and partial differential equations. Specifically, we build on the application of PINNs to SIR compartmental models and expand it a scaffolded family of mathematical models describing various infectious diseases. We show how the neural networks are capable of learning how diseases spread, forecasting their progression, and finding their unique parameters (e.g. death rate). To demonstrate the robustness and efficacy of DINNs, we apply the approach to eleven highly infectious diseases that have been modeled in increasing levels of complexity. Our computational experiments suggest that DINNs is a reliable candidate for effectively learn about the dynamics of spread and forecast its progression into the future from available real-world data., Comment: Paper accepted. Citation: "Shaier, S., Raissi, M. and Seshaiyer, P., Data-Driven Approaches for Predicting Spread of Infectious Diseases Through DINNs: Disease Informed Neural Networks, Lett. Biomath., Vol. 8, Iss. 1 (2022), pp. 71-105."
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- 2021
249. The High Latitude Spectroscopic Survey on the Nancy Grace Roman Space Telescope
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Wang, Yun, Zhai, Zhongxu, Alavi, Anahita, Massara, Elena, Pisani, Alice, Benson, Andrew, Hirata, Christopher M., Samushia, Lado, Weinberg, David H., Colbert, James, Doré, Olivier, Eifler, Tim, Heinrich, Chen, Ho, Shirley, Krause, Elisabeth, Padmanabhan, Nikhil, Spergel, David, and Teplitz, Harry I.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,General Relativity and Quantum Cosmology ,High Energy Physics - Phenomenology - Abstract
The Nancy Grace Roman Space Telescope will conduct a High Latitude Spectroscopic Survey (HLSS) over a large volume at high redshift, using the near-IR grism (1.0-1.93 $\mu$m, $R=435-865$) and the 0.28 deg$^2$ wide field camera. We present a reference HLSS which maps 2000 deg$^2$ and achieves an emission line flux limit of 10$^{-16}$ erg/s/cm$^2$ at 6.5$\sigma$, requiring $\sim$0.6 yrs of observing time. We summarize the flowdown of the Roman science objectives to the science and technical requirements of the HLSS. We construct a mock redshift survey over the full HLSS volume by applying a semi-analytic galaxy formation model to a cosmological N-body simulation, and use this mock survey to create pixel-level simulations of 4 deg$^2$ of HLSS grism spectroscopy. We find that the reference HLSS would measure $\sim$ 10 million H$\alpha$ galaxy redshifts that densely map large scale structure at $z=1-2$ and 2 million [OIII] galaxy redshifts that sparsely map structures at $z=2-3$. We forecast the performance of this survey for measurements of the cosmic expansion history with baryon acoustic oscillations and the growth of large scale structure with redshift space distortions. We also study possible deviations from the reference design, and find that a deep HLSS at $f_{\rm line}>7\times10^{-17}$erg/s/cm$^2$ over 4000 deg$^2$ (requiring $\sim$1.5 yrs of observing time) provides the most compelling stand-alone constraints on dark energy from Roman alone. This provides a useful reference for future optimizations. The reference survey, simulated data sets, and forecasts presented here will inform community decisions on the final scope and design of the Roman HLSS., Comment: 29 pages, 8 figures, ApJ submitted
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- 2021
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250. Inductive Conformal Recommender System
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Kagita, Venkateswara Rao, Pujari, Arun K, Padmanabhan, Vineet, and Kumar, Vikas
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Computer Science - Machine Learning ,Computer Science - Information Retrieval ,I.2 - Abstract
Traditional recommendation algorithms develop techniques that can help people to choose desirable items. However, in many real-world applications, along with a set of recommendations, it is also essential to quantify each recommendation's (un)certainty. The conformal recommender system uses the experience of a user to output a set of recommendations, each associated with a precise confidence value. Given a significance level $\varepsilon$, it provides a bound $\varepsilon$ on the probability of making a wrong recommendation. The conformal framework uses a key concept called \emph{nonconformity measure} that measures the strangeness of an item concerning other items. One of the significant design challenges of any conformal recommendation framework is integrating nonconformity measures with the recommendation algorithm. This paper introduces an inductive variant of a conformal recommender system. We propose and analyze different nonconformity measures in the inductive setting. We also provide theoretical proofs on the error-bound and the time complexity. Extensive empirical analysis on ten benchmark datasets demonstrates that the inductive variant substantially improves the performance in computation time while preserving the accuracy., Comment: 25 pages
- Published
- 2021
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