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204. Green dreams, local realities: Complexities of the European Union's energy transition to ensure local health and well-being in a fossil fuel-based industrial region.

Author

Dahal, Usha, Orru, Kati, Orru, Hans, and Dijst, Martin

Subjects
WELL-being, ENVIRONMENTAL health, SOCIOTECHNICAL systems, HOLISTIC medicine, FOSSILS, SYSTEMS theory, EPIDEMIOLOGICAL transition
Abstract

European Union's Green Deal is a legal obligation to EU countries to shift towards environment-friendly energy systems from fossil-fuel-based systems. This transition will bring significant global health benefits by combating climate change, but it is crucial to understand the so far understudied impacts on local communities' lives and, thus, on their health and well-being. The study proposes a novel conceptual framework based on socio-technical systems theory and the production of space theory to identify the interacting points between energy systems and health and well-being systems in the energy transition context. This framework is tested in Estonia's transitioning fossil fuel oil-shale-based energy system based on four focus group discussions, ten expert interviews, and document analysis. We innovatively pinpoint pathways, including feedback loops, through a causal loop diagram (CLD) impacting inhabitants' health and well-being from the interplay between energy and health and well-being systems. The analysis indicates that protecting and promoting health and well-being has been a challenge not only due to disruption created by the energy transition process but also due to the accumulated problems regarding socioeconomic conditions, environmental health impacts, and well-being at the local level. The compound effects of multiple existing and emerging issues, including the divergent interpretations of health and the lack of holistic support mechanisms for inhabitants to navigate the changes in sociocultural and economic space, can harm locals' health and well-being. The developed conceptual framework provides an important theoretical background to study the impacts on the mental and physical health, including social health and well-being, of the inhabitants living in the fossil-fuel-based industrial area. The CLD developed using this framework demonstrates the interacting points to avoid unintended consequences of energy transition. • Study assesses EU's energy transition impact on local health and well-being. • CLD shows the impact on inhabitants' health and well-being. • Low adaptability to socioeconomic changes creates uncertainties among inhabitants. • Local contextualized knowledge is needed in global sustainability efforts. [ABSTRACT FROM AUTHOR]

Published
2024
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207. Associations Between Extreme Temperatures and Cardiovascular Cause-Specific Mortality: Results From 27 Countries

Author

Alahmad, Barrak, Khraishah, Haitham, Royé, Dominic, Vicedo-Cabrera, Ana Maria, Guo, Yuming, Papatheodorou, Stefania I., Achilleos, Souzana, Acquaotta, Fiorella, Armstrong, Ben, Bell, Michelle L., Pan, Shih-Chun, de Sousa Zanotti Stagliorio Coelho, Micheline, Colistro, Valentina, Dang, Tran Ngoc, Van Dung, Do, De’ Donato, Francesca K., Entezari, Alireza, Guo, Yue-Liang Leon, Hashizume, Masahiro, Honda, Yasushi, Indermitte, Ene, Íñiguez, Carmen, Jaakkola, Jouni J.K., Kim, Ho, Lavigne, Eric, Lee, Whanhee, Li, Shanshan, Madureira, Joana, Mayvaneh, Fatemeh, Orru, Hans, Overcenco, Ala, Ragettli, Martina S., Ryti, Niilo R.I., Saldiva, Paulo Hilario Nascimento, Scovronick, Noah, Seposo, Xerxes, Sera, Francesco, Silva, Susana Pereira, Stafoggia, Massimo, Tobias, Aurelio, Garshick, Eric, Bernstein, Aaron S., Zanobetti, Antonella, Schwartz, Joel, Gasparrini, Antonio, and Koutrakis, Petros

Published
2023
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208. Mold, bacteria, allergens, and volatile organic compounds in homes associated with tear film break-up time, oculo-nasal symptoms, and allergic rhinitis.

Author

Wang, Juan, Janson, Christer, Gislason, Thorarinn, Gunnbjörnsdottir, Maria, Jogi, Rain, Orru, Hans, and Norbäck, Dan

Subjects
HOUSE dust mites, ALLERGIC rhinitis, VOLATILE organic compounds, CITIES & towns, ALLERGENS
Abstract

Indoor bacteria, mold, allergens, and selected volatile organic compounds (VOC) were measured at home in three Nordic cities. Data on self-reported tear film break-up time (SBUT), weekly oculo-nasal symptoms during the past three months, and allergic rhinitis of 159 adults were obtained. Among them, 58 % were females, 24.5 % were atopics, and 41 % reported home dampness. The median SBUT was 22.3 s. Oculo-nasal symptoms (15.3 %) and allergic rhinitis (32.7 %) were common. A higher level of 2-hexanone was linked to lower SBUT (p = 0.036). Higher levels of total mold (p = 0.038), allergen Fel d 1 from cat (p = 0.045), and allergen Der p 1 (p = 0.012) and Der f 1 (p = 0.036) from house dust mite (HDM), were related to more oculo-nasal symptoms. Higher levels of 3-methylfuran (p = 0.003), 2-hexanone (p = 0.037), 2-heptanone (p = 0.018), and 1-octen-3-ol (p = 0.001) were linked to oculo-nasal symptoms. Higher levels of viable bacteria (p = 0.015), 3-octanone (p = 0.049) and formaldehyde (p = 0.039) were linked to allergic rhinitis. The association between 2-heptanone and oculo-nasal symptoms (interaction p = 0.012), and between isobutyl acetate and allergic rhinitis (interaction p = 0.084) were more pronounced in women. The negative association between 2-hexanone and SBUT was stronger among atopics (interaction p = 0.098), and the links between viable bacteria and allergic rhinitis (interaction p = 0.003) and between Der f 1 and oculo-nasal symptoms (interaction p = 0.1) were more pronounced among non-atopics. In conclusion, airborne mold and bacteria, and allergens in dust were associated with oculo-nasal symptoms or allergic rhinitis. 3-Methylfuran, 2-hexanone, 1-octen-3-ol, and 2-heptanone were associated with adult oculo-nasal symptoms. Increased 3-octanone and formaldehyde were related to allergic rhinitis. [Display omitted] • Airborne mold, bacteria, and allergens in dust were related to oculo-nasal symptoms. • Some individual VOC in dwellings were associated with oculo-nasal symptoms. • Increased 3-octanone and formaldehyde in dwellings were related to allergic rhinitis. • Some VOC-related health associations were stronger among females and atopics. [ABSTRACT FROM AUTHOR]

Published
2024
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213. The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

Author

Tran, Khanh Bao, Lang, Justin J, Compton, Kelly, Xu, Rixing, Acheson, Alistair R, Henrikson, Hannah Jacqueline, Kocarnik, Jonathan M, Penberthy, Louise, Aali, Amirali, Abbas, Qamar, Abbasi, Behzad, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abbastabar, Hedayat, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdelwahab, Ahmed Abdelwahab, Abdoli, Gholamreza, Abdulkadir, Hanan Abdulkadir, Abedi, Aidin, Abegaz, Kedir Hussein, Abidi, Hassan, Aboagye, Richard Gyan, Abolhassani, Hassan, Absalan, Abdorrahim, Abtew, Yonas Derso, Abubaker Ali, Hiwa, Abu-Gharbieh, Eman, Achappa, Basavaprabhu, Acuna, Juan Manuel, Addison, Daniel, Addo, Isaac Yeboah, Adegboye, Oyelola A, Adesina, Miracle Ayomikun, Adnan, Mohammad, Adnani, Qorinah Estiningtyas Sakilah, Advani, Shailesh M, Afrin, Sumia, Afzal, Muhammad Sohail, Aggarwal, Manik, Ahinkorah, Bright Opoku, Ahmad, Araz Ramazan, Ahmad, Rizwan, Ahmad, Sajjad, Ahmad, Sohail, Ahmadi, Sepideh, Ahmed, Haroon, Ahmed, Luai A, Ahmed, Muktar Beshir, Ahmed Rashid, Tarik, Aiman, Wajeeha, Ajami, Marjan, Akalu, Gizachew Taddesse, Akbarzadeh-Khiavi, Mostafa, Aklilu, Addis, Akonde, Maxwell, Akunna, Chisom Joyqueenet, Al Hamad, Hanadi, Alahdab, Fares, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alessy, Saleh Ali, Algammal, Abdelazeem M, Al-Hanawi, Mohammed Khaled, Alhassan, Robert Kaba, Ali, Beriwan Abdulqadir, Ali, Liaqat, Ali, Syed Shujait, Alimohamadi, Yousef, Alipour, Vahid, Aljunid, Syed Mohamed, Alkhayyat, Motasem, Al-Maweri, Sadeq Ali Ali, Almustanyir, Sami, Alonso, Nivaldo, Alqalyoobi, Shehabaldin, Al-Raddadi, Rajaa M, Al-Rifai, Rami H Hani, Al-Sabah, Salman Khalifah, Al-Tammemi, Ala'a B, Altawalah, Haya, Alvis-Guzman, Nelson, Amare, Firehiwot, Ameyaw, Edward Kwabena, Aminian Dehkordi, Javad Javad, Amirzade-Iranaq, Mohammad Hosein, Amu, Hubert, Amusa, Ganiyu Adeniyi, Ancuceanu, Robert, Anderson, Jason A, Animut, Yaregal Animut, Anoushiravani, Amir, Anoushirvani, Ali Arash, Ansari-Moghaddam, Alireza, Ansha, Mustafa Geleto, Antony, Benny, Antwi, Maxwell Hubert, Anwar, Sumadi Lukman, Anwer, Razique, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Arab-Zozani, Morteza, Aremu, Olatunde, Argaw, Ayele Mamo, Ariffin, Hany, Aripov, Timur, Arshad, Muhammad, Artaman, Al, Arulappan, Judie, Aruleba, Raphael Taiwo, Aryannejad, Armin, Asaad, Malke, Asemahagn, Mulusew A, Asemi, Zatollah, Asghari-Jafarabadi, Mohammad, Ashraf, Tahira, Assadi, Reza, Athar, Mohammad, Athari, Seyyed Shamsadin, Atout, Maha Moh'd Wahbi, Attia, Sameh, Aujayeb, Avinash, Ausloos, Marcel, Avila-Burgos, Leticia, Awedew, Atalel Fentahun, Awoke, Mamaru Ayenew, Awoke, Tewachew, Ayala Quintanilla, Beatriz Paulina, Ayana, Tegegn Mulatu, Ayen, Solomon Shitu, Azadi, Davood, Azadnajafabad, Sina, Azami-Aghdash, Saber, Azanaw, Melkalem Mamuye, Azangou-Khyavy, Mohammadreza, Azari Jafari, Amirhossein, Azizi, Hosein, Azzam, Ahmed Y Y, Babajani, Amirhesam, Badar, Muhammad, Badiye, Ashish D, Baghcheghi, Nayereh, Bagheri, Nader, Bagherieh, Sara, Bahadory, Saeed, Baig, Atif Amin, Baker, Jennifer L, Bakhtiari, Ahad, Bakshi, Ravleen Kaur, Banach, Maciej, Banerjee, Indrajit, Bardhan, Mainak, Barone-Adesi, Francesco, Barra, Fabio, Barrow, Amadou, Bashir, Nasir Z, Bashiri, Azadeh, Basu, Saurav, Batiha, Abdul-Monim Mohammad, Begum, Aeysha, Bekele, Alehegn Bekele, Belay, Alemayehu Sayih, Belete, Melaku Ashagrie, Belgaumi, Uzma Iqbal, Bell, Arielle Wilder, Belo, Luis, Benzian, Habib, Berhie, Alemshet Yirga, Bermudez, Amiel Nazer C, Bernabe, Eduardo, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhandari, Bharti Bhandari, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhattacharyya, Krittika, Bhojaraja, Vijayalakshmi S, Bhuyan, Soumitra S, Bibi, Sadia, Bilchut, Awraris Hailu, Bintoro, Bagas Suryo, Biondi, Antonio, Birega, Mesfin Geremaw Birega, Birhan, Habitu Eshetu, Bjørge, Tone, Blyuss, Oleg, Bodicha, Belay Boda Abule, Bolla, Srinivasa Rao, Boloor, Archith, Bosetti, Cristina, Braithwaite, Dejana, Brauer, Michael, Brenner, Hermann, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Buchanan, Christina Maree, Bulamu, Norma B, Bustamante-Teixeira, Maria Teresa, Butt, Muhammad Hammad, Butt, Nadeem Shafique, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cámera, Luis Alberto, Cao, Chao, Cao, Yin, Carreras, Giulia, Carvalho, Márcia, Cembranel, Francieli, Cerin, Ester, Chakraborty, Promit Ananyo, Charalampous, Periklis, Chattu, Vijay Kumar, Chimed-Ochir, Odgerel, Chirinos-Caceres, Jesus Lorenzo, Cho, Daniel Youngwhan, Cho, William C S, Christopher, Devasahayam J, Chu, Dinh-Toi, Chukwu, Isaac Sunday, Cohen, Aaron J, Conde, Joao, Cortés, Sandra, Costa, Vera Marisa, Cruz-Martins, Natália, Culbreth, Garland T, Dadras, Omid, Dagnaw, Fentaw Teshome, Dahlawi, Saad M A, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Daneshpajouhnejad, Parnaz, Danielewicz, Anna, Dao, An Thi Minh, Darvishi Cheshmeh Soltani, Reza, Darwesh, Aso Mohammad, Das, Saswati, Davitoiu, Dragos Virgil, Davtalab Esmaeili, Elham, De la Hoz, Fernando Pio, Debela, Sisay Abebe, Dehghan, Azizallah, Demisse, Biniyam, Demisse, Fitsum Wolde, Denova-Gutiérrez, Edgar, Derakhshani, Afshin, Derbew Molla, Meseret, Dereje, Diriba, Deribe, Kalkidan Solomon, Desai, Rupak, Desalegn, Markos Desalegn, Dessalegn, Fikadu Nugusu, Dessalegni, Samuel Abebe A, Dessie, Gashaw, Desta, Abebaw Alemayehu, Dewan, Syed Masudur Rahman, Dharmaratne, Samath Dhamminda, Dhimal, Meghnath, Dianatinasab, Mostafa, Diao, Nancy, Diaz, Daniel, Digesa, Lankamo Ena, Dixit, Shilpi Gupta, Doaei, Saeid, Doan, Linh Phuong, Doku, Paul Narh, Dongarwar, Deepa, dos Santos, Wendel Mombaque, Driscoll, Tim Robert, Dsouza, Haneil Larson, Durojaiye, Oyewole Christopher, Edalati, Sareh, Eghbalian, Fatemeh, Ehsani-Chimeh, Elham, Eini, Ebrahim, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, Ekwueme, Donatus U, El Tantawi, Maha, Elbahnasawy, Mostafa Ahmed, Elbarazi, Iffat, Elghazaly, Hesham, Elhadi, Muhammed, El-Huneidi, Waseem, Emamian, Mohammad Hassan, Engelbert Bain, Luchuo, Enyew, Daniel Berhanie, Erkhembayar, Ryenchindorj, Eshetu, Tegegne, Eshrati, Babak, Eskandarieh, Sharareh, Espinosa-Montero, Juan, Etaee, Farshid, Etemadimanesh, Azin, Eyayu, Tahir, Ezeonwumelu, Ifeanyi Jude, Ezzikouri, Sayeh, Fagbamigbe, Adeniyi Francis, Fahimi, Saman, Fakhradiyev, Ildar Ravisovich, Faraon, Emerito Jose A, Fares, Jawad, Farmany, Abbas, Farooque, Umar, Farrokhpour, Hossein, Fasanmi, Abidemi Omolara, Fatehizadeh, Ali, Fatima, Wafa, Fattahi, Hamed, Fekadu, Ginenus, Feleke, Berhanu Elfu, Ferrari, Allegra Allegra, Ferrero, Simone, Ferro Desideri, Lorenzo, Filip, Irina, Fischer, Florian, Foroumadi, Roham, Foroutan, Masoud, Fukumoto, Takeshi, Gaal, Peter Andras, Gad, Mohamed M, Gadanya, Muktar A, Gaipov, Abduzhappar, Galehdar, Nasrin, Gallus, Silvano, Garg, Tushar, Gaspar Fonseca, Mariana, Gebremariam, Yosef Haile, Gebremeskel, Teferi Gebru, Gebremichael, Mathewos Alemu, Geda, Yohannes Fikadu, Gela, Yibeltal Yismaw, Gemeda, Belete Negese Belete, Getachew, Melaku, Getachew, Motuma Erena, Ghaffari, Kazem, Ghafourifard, Mansour, Ghamari, Seyyed-Hadi, Ghasemi Nour, Mohammad, Ghassemi, Fariba, Ghimire, Ajnish, Ghith, Nermin, Gholamalizadeh, Maryam, Gholizadeh Navashenaq, Jamshid, Ghozy, Sherief, Gilani, Syed Amir, Gill, Paramjit Singh, Ginindza, Themba G, Gizaw, Abraham Tamirat T, Glasbey, James C, Godos, Justyna, Goel, Amit, Golechha, Mahaveer, Goleij, Pouya, Golinelli, Davide, Golitaleb, Mohamad, Gorini, Giuseppe, Goulart, Bárbara Niegia Garcia, Grosso, Giuseppe, Guadie, Habtamu Alganeh, Gubari, Mohammed Ibrahim Mohialdeen, Gudayu, Temesgen Worku, Guerra, Maximiliano Ribeiro, Gunawardane, Damitha Asanga, Gupta, Bhawna, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Gurara, Mekdes Kondale, Guta, Alemu, Habibzadeh, Parham, Haddadi Avval, Atlas, Hafezi-Nejad, Nima, Hajj Ali, Adel, Haj-Mirzaian, Arvin, Halboub, Esam S, Halimi, Aram, Halwani, Rabih, Hamadeh, Randah R, Hameed, Sajid, Hamidi, Samer, Hanif, Asif, Hariri, Sanam, Harlianto, Netanja I, Haro, Josep Maria, Hartono, Risky Kusuma, Hasaballah, Ahmed I, Hasan, S M Mahmudul, Hasani, Hamidreza, Hashemi, Seyedeh Melika, Hassan, Abbas M, Hassanipour, Soheil, Hayat, Khezar, Heidari, Golnaz, Heidari, Mohammad, Heidarymeybodi, Zahra, Herrera-Serna, Brenda Yuliana, Herteliu, Claudiu, Hezam, Kamal, Hiraike, Yuta, Hlongwa, Mbuzeleni Mbuzeleni, Holla, Ramesh, Holm, Marianne, Horita, Nobuyuki, Hoseini, Mohammad, Hossain, Md Mahbub, Hossain, Mohammad Bellal Hossain, Hosseini, Mohammad-Salar, Hosseinzadeh, Ali, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Huang, Junjie, Hugo, Fernando N, Humayun, Ayesha, Hussain, Salman, Hussein, Nawfal R, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Iftikhar, Pulwasha Maria, Ikuta, Kevin S, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Immurana, Mustapha, Innos, Kaire, Iranpour, Pooya, Irham, Lalu Muhammad, Islam, Md Shariful, Islam, Rakibul M, Islami, Farhad, Ismail, Nahlah Elkudssiah, Isola, Gaetano, Iwagami, Masao, J, Linda Merin, Jaiswal, Abhishek, Jakovljevic, Mihajlo, Jalili, Mahsa, Jalilian, Shahram, Jamshidi, Elham, Jang, Sung-In, Jani, Chinmay T, Javaheri, Tahereh, Jayarajah, Umesh Umesh, Jayaram, Shubha, Jazayeri, Seyed Behzad, Jebai, Rime, Jemal, Bedru, Jeong, Wonjeong, Jha, Ravi Prakash, Jindal, Har Ashish, John-Akinola, Yetunde O, Jonas, Jost B, Joo, Tamas, Joseph, Nitin, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Ali, Kacimi, Salah Eddine Oussama, Kadashetti, Vidya, Kahe, Farima, Kakodkar, Pradnya Vishal, Kalankesh, Laleh R, Kalankesh, Leila R, Kalhor, Rohollah, Kamal, Vineet Kumar, Kamangar, Farin, Kamath, Ashwin, Kanchan, Tanuj, Kandaswamy, Eswar, Kandel, Himal, Kang, HyeJung, Kanno, Girum Gebremeskel, Kapoor, Neeti, Kar, Sitanshu Sekhar, Karanth, Shama D, Karaye, Ibraheem M, Karch, André, Karimi, Amirali, Kassa, Bekalu Getnet, Katoto, Patrick DMC, Kauppila, Joonas H, Kaur, Harkiran, Kebede, Abinet Gebremickael, Keikavoosi-Arani, Leila, Kejela, Gemechu Gemechu, Kemp Bohan, Phillip M, Keramati, Maryam, Keykhaei, Mohammad, Khajuria, Himanshu, Khan, Abbas, Khan, Abdul Aziz Khan, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khan, Md Nuruzzaman, Khan, Moien AB, Khanali, Javad, Khatab, Khaled, Khatatbeh, Moawiah Mohammad, Khatib, Mahalaqua Nazli, Khayamzadeh, Maryam, Khayat Kashani, Hamid Reza, Khazeei Tabari, Mohammad Amin, Khezeli, Mehdi, Khodadost, Mahmoud, Kim, Min Seo, Kim, Yun Jin, Kisa, Adnan, Kisa, Sezer, Klugar, Miloslav, Klugarová, Jitka, Kolahi, Ali-Asghar, Kolkhir, Pavel, Kompani, Farzad, Koul, Parvaiz A, Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Krishan, Kewal, Krishnamoorthy, Yuvaraj, Kucuk Bicer, Burcu, Kugbey, Nuworza, Kulimbet, Mukhtar, Kumar, Akshay, Kumar, G Anil, Kumar, Narinder, Kurmi, Om P, Kuttikkattu, Ambily, La Vecchia, Carlo, Lahiri, Arista, Lal, Dharmesh Kumar, Lám, Judit, Lan, Qing, Landires, Iván, Larijani, Bagher, Lasrado, Savita, Lau, Jerrald, Lauriola, Paolo, Ledda, Caterina, Lee, Sang-woong, Lee, Shaun Wen Huey, Lee, Wei-Chen, Lee, Yeong Yeh, Lee, Yo Han, Legesse, Samson Mideksa, Leigh, James, Leong, Elvynna, Li, Ming-Chieh, Lim, Stephen S, Liu, Gang, Liu, Jue, Lo, Chun-Han, Lohiya, Ayush, Lopukhov, Platon D, Lorenzovici, László, Lotfi, Mojgan, Loureiro, Joana A, Lunevicius, Raimundas, Madadizadeh, Farzan, Mafi, Ahmad R, Magdeldin, Sameh, Mahjoub, Soleiman, Mahmoodpoor, Ata, Mahmoudi, Morteza, Mahmoudimanesh, Marzieh, Mahumud, Rashidul Alam, Majeed, Azeem, Majidpoor, Jamal, Makki, Alaa, Makris, Konstantinos Christos, Malakan Rad, Elaheh, Malekpour, Mohammad-Reza, Malekzadeh, Reza, Malik, Ahmad Azam, Mallhi, Tauqeer Hussain, Mallya, Sneha Deepak, Mamun, Mohammed A, Manda, Ana Laura, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, Martini, Santi, Martorell, Miquel, Masoudi, Sahar, Masoumi, Seyedeh Zahra, Matei, Clara N, Mathews, Elezebeth, Mathur, Manu Raj, Mathur, Vasundhara, McKee, Martin, Meena, Jitendra Kumar, Mehmood, Khalid, Mehrabi Nasab, Entezar, Mehrotra, Ravi, Melese, Addisu, Mendoza, Walter, Menezes, Ritesh G, Mengesha, SIsay Derso, Mensah, Laverne G, Mentis, Alexios-Fotios A, Mera-Mamián, Andry Yasmid Mera, Meretoja, Tuomo J, Merid, Mehari Woldemariam, Mersha, Amanual Getnet, Meselu, Belsity Temesgen, Meshkat, Mahboobeh, Mestrovic, Tomislav, Miao Jonasson, Junmei, Miazgowski, Tomasz, Michalek, Irmina Maria, Mijena, Gelana Fekadu Worku, Miller, Ted R, Mir, Shabir Ahmad, Mirinezhad, Seyed Kazem, Mirmoeeni, Seyyedmohammadsadeq, Mirza-Aghazadeh-Attari, Mohammad, Mirzaei, Hamed, Mirzaei, Hamid Reza, Misganaw, Abay Sisay, Misra, Sanjeev, Mohammad, Karzan Abdulmuhsin, Mohammadi, Esmaeil, Mohammadi, Mokhtar, Mohammadian-Hafshejani, Abdollah, Mohammadpourhodki, Reza, Mohammed, Arif, Mohammed, Shafiu, Mohan, Syam, Mohseni, Mohammad, Moka, Nagabhishek, Mokdad, Ali H, Molassiotis, Alex, Molokhia, Mariam, Momenzadeh, Kaveh, Momtazmanesh, Sara, Monasta, Lorenzo, Mons, Ute, Montasir, Ahmed Al, Montazeri, Fateme, Montero, Arnulfo, Moosavi, Mohammad Amin, Moradi, Abdolvahab, Moradi, Yousef, Moradi Sarabi, Mostafa, Moraga, Paula, Morawska, Lidia, Morrison, Shane Douglas, Morze, Jakub, Mosapour, Abbas, Mostafavi, Ebrahim, Mousavi, Seyyed Meysam, Mousavi Isfahani, Haleh, Mousavi Khaneghah, Amin, Mpundu-Kaambwa, Christine, Mubarik, Sumaira, Mulita, Francesk, Munblit, Daniel, Munro, Sandra B, Murillo-Zamora, Efrén, Musa, Jonah, Nabhan, Ashraf F, Nagarajan, Ahamarshan Jayaraman, Nagaraju, Shankar Prasad, Nagel, Gabriele, Naghipour, Mohammadreza, Naimzada, Mukhammad David, Nair, Tapas Sadasivan, Naqvi, Atta Abbas, Narasimha Swamy, Sreenivas, Narayana, Aparna Ichalangod, Nassereldine, Hasan, Natto, Zuhair S, Nayak, Biswa Prakash, Ndejjo, Rawlance, Nduaguba, Sabina Onyinye, Negash, Wogene Wogene, Nejadghaderi, Seyed Aria, Nejati, Kazem, Neupane Kandel, Sandhya, Nguyen, Huy Van Nguyen, Niazi, Robina Khan, Noor, Nurulamin M, Noori, Maryam, Noroozi, Nafise, Nouraei, Hasti, Nowroozi, Ali, Nuñez-Samudio, Virginia, Nzoputam, Chimezie Igwegbe, Nzoputam, Ogochukwu Janet, Oancea, Bogdan, Odukoya, Oluwakemi Ololade, Oghenetega, Onome Bright, Ogunsakin, Ropo Ebenezer, Oguntade, Ayodipupo Sikiru, Oh, In-Hwan, Okati-Aliabad, Hassan, Okekunle, Akinkunmi Paul, Olagunju, Andrew T, Olagunju, Tinuke O, Olakunde, Babayemi Oluwaseun, Olufadewa, Isaac Iyinoluwa, Omer, Emad, Omonisi, Abidemi E Emmanuel, Ong, Sokking, Onwujekwe, Obinna E, Orru, Hans, Otstavnov, Stanislav S, Oulhaj, Abderrahim, Oumer, Bilcha, Owopetu, Oluwatomi Funbi, Oyinloye, Babatunji Emmanuel, P A, Mahesh, Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Pakbin, Babak, Pakshir, Keyvan, Pakzad, Reza, Palicz, Tamás, Pana, Adrian, Pandey, Anamika, Pandey, Ashok, Pant, Suman, Pardhan, Shahina, Park, Eun-Cheol, Park, Eun-Kee, Park, Seoyeon, Patel, Jay, Pati, Siddhartha, Paudel, Rajan, Paudel, Uttam, Paun, Mihaela, Pazoki Toroudi, Hamidreza, Peng, Minjin, Pereira, Jeevan, Pereira, Renato B, Perna, Simone, Perumalsamy, Navaraj, Pestell, Richard G, Pezzani, Raffaele, Piccinelli, Cristiano, Pillay, Julian David, Piracha, Zahra Zahid, Pischon, Tobias, Postma, Maarten J, Pourabhari Langroudi, Ashkan, Pourshams, Akram, Pourtaheri, Naeimeh, Prashant, Akila, Qadir, Mirza Muhammad Fahd, Quazi Syed, Zahiruddin, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Radhakrishnan, Raghu Anekal, Radhakrishnan, Venkatraman, Raeisi, Mojtaba, Rafiee, Ata, Rafiei, Alireza, Raheem, Nasiru, Rahim, Fakher, Rahman, Md Obaidur, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rahmani, Shayan, Rahmanian, Vahid, Rajai, Nazanin, Rajesh, Aashish, Ram, Pradhum, Ramezanzadeh, Kiana, Rana, Juwel, Ranabhat, Kamal, Ranasinghe, Priyanga, Rao, Chythra R, Rao, Sowmya J, Rashedi, Sina, Rashidi, Amirfarzan, Rashidi, Mahsa, Rashidi, Mohammad-Mahdi, Ratan, Zubair Ahmed, Rawaf, David Laith, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Razeghinia, Mohammad Sadegh, Rehman, Ashfaq Ur, Rehman, Inayat ur, Reitsma, Marissa B, Renzaho, Andre M N, Rezaei, Maryam, Rezaei, Nazila, Rezaei, Negar, Rezaei, Nima, Rezaei, Saeid, Rezaeian, Mohsen, Rezapour, Aziz, Riad, Abanoub, Rikhtegar, Reza, Rios-Blancas, Maria, Roberts, Thomas J, Rohloff, Peter, Romero-Rodríguez, Esperanza, Roshandel, Gholamreza, Rwegerera, Godfrey M, S, Manjula, Saber-Ayad, Maha Mohamed, Saberzadeh-Ardestani, Bahar, Sabour, Siamak, Saddik, Basema, Sadeghi, Erfan, Saeb, Mohammad Reza, Saeed, Umar, Safaei, Mohsen, Safary, Azam, Sahebazzamani, Maryam, Sahebkar, Amirhossein, Sahoo, Harihar, Sajid, Mirza Rizwan, Salari, Hedayat, Salehi, Sana, Salem, Marwa Rashad, Salimzadeh, Hamideh, Samodra, Yoseph Leonardo, Samy, Abdallah M, Sanabria, Juan, Sankararaman, Senthilkumar, Sanmarchi, Francesco, Santric-Milicevic, Milena M, Saqib, Muhammad Arif Nadeem, Sarveazad, Arash, Sarvi, Fatemeh, Sathian, Brijesh, Satpathy, Maheswar, Sayegh, Nicolas, Schneider, Ione Jayce Ceola, Schwarzinger, Michaël, Šekerija, Mario, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Seylani, Allen, Seyoum, Kenbon, Sha, Feng, Shafaat, Omid, Shah, Pritik A, Shahabi, Saeed, Shahid, Izza, Shahrbaf, Mohammad Amin, Shahsavari, Hamid R, Shaikh, Masood Ali, Shaka, Mohammed Feyisso, Shaker, Elaheh, Shannawaz, Mohammed, Sharew, Mequannent Melaku Sharew, Sharifi, Azam, Sharifi-Rad, Javad, Sharma, Purva, Shashamo, Bereket Beyene, Sheikh, Aziz, Sheikh, Mahdi, Sheikhbahaei, Sara, Sheikhi, Rahim Ali, Sheikhy, Ali, Shepherd, Peter Robin, Shetty, Adithi, Shetty, Jeevan K, Shetty, Ranjitha S, Shibuya, Kenji, Shirkoohi, Reza, Shirzad-Aski, Hesamaddin, Shivakumar, K M, Shivalli, Siddharudha, Shivarov, Velizar, Shobeiri, Parnian, Shokri Varniab, Zahra, Shorofi, Seyed Afshin, Shrestha, Sunil, Sibhat, Migbar Mekonnen, Siddappa Malleshappa, Sudeep K, Sidemo, Negussie Boti, Silva, Diego Augusto Santos, Silva, Luís Manuel Lopes Rodrigues, Silva Julian, Guilherme, Silvestris, Nicola, Simegn, Wudneh, Singh, Achintya Dinesh, Singh, Ambrish, Singh, Garima, Singh, Harpreet, Singh, Jasvinder A, Singh, Jitendra Kumar, Singh, Paramdeep, Singh, Surjit, Sinha, Dhirendra Narain, Sinke, Abiy H, Siraj, Md Shahjahan, Sitas, Freddy, Siwal, Samarjeet Singh, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Socea, Bogdan, Soeberg, Matthew J, Sofi-Mahmudi, Ahmad, Solomon, Yonatan, Soltani-Zangbar, Mohammad Sadegh, Song, Suhang, Song, Yimeng, Sorensen, Reed J D, Soshnikov, Sergey, Sotoudeh, Houman, Sowe, Alieu, Sufiyan, Mu'awiyyah Babale, Suk, Ryan, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sultana, Saima, Sur, Daniel, Szócska, Miklós, Tabaeian, Seidamir Pasha, Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabuchi, Takahiro, Tadbiri, Hooman, Taheri, Ensiyeh, Taheri, Majid, Taheri Soodejani, Moslem, Takahashi, Ken, Talaat, Iman M, Tampa, Mircea, Tan, Ker-Kan, Tat, Nathan Y, Tat, Vivian Y, Tavakoli, Ahmad, Tavakoli, Arash, Tehrani-Banihashemi, Arash, Tekalegn, Yohannes, Tesfay, Fisaha Haile, Thapar, Rekha, Thavamani, Aravind, Thoguluva Chandrasekar, Viveksandeep, Thomas, Nihal, Thomas, Nikhil Kenny, Ticoalu, Jansje Henny Vera, Tiyuri, Amir, Tollosa, Daniel Nigusse, Topor-Madry, Roman, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Traini, Eugenio, Tran, Mai Thi Ngoc, Tripathy, Jaya Prasad, Ukke, Gebresilasea Gendisha, Ullah, Irfan, Ullah, Saif, Ullah, Sana, Unnikrishnan, Bhaskaran, Vacante, Marco, Vaezi, Maryam, Valadan Tahbaz, Sahel, Valdez, Pascual R, Vardavas, Constantine, Varthya, Shoban Babu, Vaziri, Siavash, Velazquez, Diana Zuleika, Veroux, Massimiliano, Villeneuve, Paul J, Violante, Francesco S, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vo, Bay, Vu, Linh Gia, Wadood, Abdul Wadood, Waheed, Yasir, Walde, Mandaras Tariku, Wamai, Richard G, Wang, Cong, Wang, Fang, Wang, Ning, Wang, Yu, Ward, Paul, Waris, Abdul, Westerman, Ronny, Wickramasinghe, Nuwan Darshana, Woldemariam, Melat, Woldu, Berhanu, Xiao, Hong, Xu, Suowen, Xu, Xiaoyue, Yadav, Lalit, Yahyazadeh Jabbari, Seyed Hossein, Yang, Lin, Yazdanpanah, Fereshteh, Yeshaw, Yigizie, Yismaw, Yazachew, Yonemoto, Naohiro, Younis, Mustafa Z, Yousefi, Zabihollah, Yousefian, Fatemeh, Yu, Chuanhua, Yu, Yong, Yunusa, Ismaeel, Zahir, Mazyar, Zaki, Nazar, Zaman, Burhan Abdullah, Zangiabadian, Moein, Zare, Fariba, Zare, Iman, Zareshahrabadi, Zahra, Zarrintan, Armin, Zastrozhin, Mikhail Sergeevich, Zeineddine, Mohammad A, Zhang, Dongyu, Zhang, Jianrong, Zhang, Yunquan, Zhang, Zhi-Jiang, Zhou, Linghui, Zodpey, Sanjay, Zoladl, Mohammad, Vos, Theo, Hay, Simon I, Force, Lisa M, and Murray, Christopher J L

Abstract

Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally.

Published
2022
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214. Correction: Corrigendum: A large light-mass component of cosmic rays at 1017–1017.5 electronvolts from radio observations

Author

Buitink, S., Corstanje, A., Falcke, H., Hörandel, J. R., Huege, T., Nelles, A., Rachen, J. P., Rossetto, L., Schellart, P., Scholten, O., ter Veen, S., Thoudam, S., Trinh, T. N. G., Anderson, J., Asgekar, A., Avruch, I. M., Bell, M. E., Bentum, M. J., Bernardi, G., Best, P., Bonafede, A., Breitling, F., Broderick, J. W., Brouw, W. N., Brüggen, M., Butcher, H. R., Carbone, D., Ciardi, B., Conway, J. E., de Gasperin, F., de Geus, E., Deller, A., Dettmar, R.-J., van Diepen, G., Duscha, S., Eislöffel, J., Engels, D., Enriquez, J. E., Fallows, R. A., Fender, R., Ferrari, C., Frieswijk, W., Garrett, M. A., Grießmeier, J. M., Gunst, A. W., van Haarlem, M. P., Hassall, T. E., Heald, G., Hessels, J. W. T., Hoeft, M., Horneffer, A., Iacobelli, M., Intema, H., Juette, E., Karastergiou, A., Kondratiev, V. I., Kramer, M., Kuniyoshi, M., Kuper, G., van Leeuwen, J., Loose, G. M., Maat, P., Mann, G., Markoff, S., McFadden, R., McKay-Bukowski, D., McKean, J. P., Mevius, M., Mulcahy, D. D., Munk, H., Norden, M. J., Orru, E., Paas, H., Pandey-Pommier, M., Pandey, V. N., Pietka, M., Pizzo, R., Polatidis, A. G., Reich, W., Röttgering, H. J. A., Scaife, A. M. M., Schwarz, D. J., Serylak, M., Sluman, J., Smirnov, O., Stappers, B. W., Steinmetz, M., Stewart, A., Swinbank, J., Tagger, M., Tang, Y., Tasse, C., Toribio, M. C., Vermeulen, R., Vocks, C., Vogt, C., van Weeren, R. J., Wijers, R. A. M. J., Wijnholds, S. J., Wise, M. W., Wucknitz, O., Yatawatta, S., Zarka, P., and Zensus, J. A.

Published
2016
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217. Fetal programming of atherosclerosis: may the barker hypothesis explain the susceptibility of a subset of patients to develop stroke or cardiac infarct?

Author

GEROSA, C., FAA, G., FANNI, D., CERRONE, G., SURI, J. S., BARCELLONA, D., CONI, P., CONGIU, T., LAI, M. L., PIRAS, M., CAU, F., COGHE, F., BALESTRIERI, A., CAU, R., ORRU', G., SCANO, A., VAN EYKEN, P., LA NASA, G., CAMPAGNA, M., and CASTAGNOLA, M.

Abstract

The risk stratification of young adults between subjects who will develop a mild form of atherosclerosis and subjects who will undergo a severe disease remains inaccurate. In the eighties of the previous century, David JP Barker has demonstrated the relationship between fetal conditions and occurrence of pathologies in adulthood. In this paper, the multiple evidence that might explain the increased susceptibility to severe forms of atherosclerosis, including stroke and cardiac infarct, in subjects who underwent intrauterine growth restriction (IUGR) will be analyzed. Specifically, we will review those inter-connected data indicating an association between a low weight at birth and an adult phenotype which might favor a severe outcome of atherosclerosis. Young and adult subjects born too small (IUGR) or too early (pre-terms) might represent a subgroup of "at risk subjects", more susceptible toward severe forms of atherosclerosis. Given that low birth weight (LBW) may be considered a surrogate of IUGR, this phenotypic feature could be considered among those indispensable clinical data collected in every patient presenting with atherosclerosis, irrespectively of age. According to the hypothesis that structural arterial changes might represent the link between LBW and susceptibility to atherosclerosis later in life, we suggest that the prevention of atherosclerosis should begin at birth. Regenerative and physiological substances such as thymosin Beta-4 could be challenged for a new "arterial regenerative medicine" in the perinatal period. The goal of this new approach should be the reinforcement of the structure of the arterial wall, allowing LBW newborns to avoid the most severe complications of atherosclerosis later in life: a dream that our research could contribute to bringing to life. [ABSTRACT FROM AUTHOR]

Published
2021

218. Global, regional, and national burden of mortality associated with short-term temperature variability from 2000–19: a three-stage modelling study

Author

Wu, Yao, Li, Shanshan, Zhao, Qi, Wen, Bo, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J K, Katsouyanni, Klea, Hurtado Diaz, Magali, Ragettli, Martina S, Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Correa, Patricia Matus, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Guo, Yue Leon, Bell, Michelle L, and Guo, Yuming

Abstract

Increased mortality risk is associated with short-term temperature variability. However, to our knowledge, there has been no comprehensive assessment of the temperature variability-related mortality burden worldwide. In this study, using data from the MCC Collaborative Research Network, we first explored the association between temperature variability and mortality across 43 countries or regions. Then, to provide a more comprehensive picture of the global burden of mortality associated with temperature variability, global gridded temperature data with a resolution of 0·5° × 0·5° were used to assess the temperature variability-related mortality burden at the global, regional, and national levels. Furthermore, temporal trends in temperature variability-related mortality burden were also explored from 2000–19.

Published
2022
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219. Fetal programming of COVID-19: may the barker hypothesis explain the susceptibility of a subset of young adults to develop severe disease?

Author

GEROSA, C., FAA, G., FANNI, D., MANCHIA, M., SURI, J. S., RAVARINO, A., BARCELLONA, D., PICHIRI, G., CONI, P., CONGIU, T., PIRAS, M., CERRONE, G., CAU, F., LEDDA, F., AIMOLA, V., COGHE, F., PORCU, M., CAU, R., ORRU’, G., and VAN EYKEN, P.

Abstract

The risk stratification of young adults between subjects who will develop a mild form COVID-19 and subjects who will undergo a severe disease remains inaccurate. In this review, we propose that the Barker hypothesis might explain the increased susceptibility to severe forms of COVID-19 in subjects who underwent intrauterine growth restriction (IUGR). In this paper evidence indicating an association between a low birth weight and an adult phenotype which might favor a severe outcome of SARS-CoV-2 infection are presented: lower lung functional capacity; increased respiratory morbidity; changes in fibrinogen and Factor VII serum levels and dysregulation of the hemostasis and thrombosis system; acquisition of a pro-thrombotic phenotype; low nephron number, with decreased ability to sustain renal function and increased renal morbidity; heart remodeling, with a less efficient cardiac function; endothelial dysfunction, a risk factor for the insurgence of the multiple organ failure; remodeling of arteries, with changes in the elastic properties of the arterial wall, predisposing to the insurgence and progression of atherosclerosis; dysfunction of the innate immune system, a risk factor for immune diseases in adulthood. These data suggest that young and adult subjects born too small (IUGR) or too early (pre-terms) might represent a subgroup of “at risk subjects”, more susceptible toward severe forms of COVID-19. Given that LBW may be considered a surrogate of IUGR, this phenotypic marker should be included among the indispensable clinical data collected in every patient presenting with SARSCOV- 2 infection, irrespectively of his/her age. [ABSTRACT FROM AUTHOR]

Published
2021

220. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019

Author

Kocarnik, Jonathan M., Compton, Kelly, Dean, Frances E., Fu, Weijia, Gaw, Brian L., Harvey, James D., Henrikson, Hannah Jacqueline, Lu, Dan, Pennini, Alyssa, Xu, Rixing, Ababneh, Emad, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd-Elsalam, Sherief M., Abdoli, Amir, Abedi, Aidin, Abidi, Hassan, Abolhassani, Hassan, Adedeji, Isaac Akinkunmi, Adnani, Qorinah Estiningtyas Sakilah, Advani, Shailesh M., Afzal, Muhammad Sohail, Aghaali, Mohammad, Ahinkorah, Bright Opoku, Ahmad, Sajjad, Ahmad, Tauseef, Ahmadi, Ali, Ahmadi, Sepideh, Ahmed Rashid, Tarik, Ahmed Salih, Yusra, Akalu, Gizachew Taddesse, Aklilu, Addis, Akram, Tayyaba, Akunna, Chisom Joyqueenet, Al Hamad, Hanadi, Alahdab, Fares, Al-Aly, Ziyad, Ali, Saqib, Alimohamadi, Yousef, Alipour, Vahid, Aljunid, Syed Mohamed, Alkhayyat, Motasem, Almasi-Hashiani, Amir, Almasri, Nihad A., Al-Maweri, Sadeq Ali Ali, Almustanyir, Sami, Alonso, Nivaldo, Alvis-Guzman, Nelson, Amu, Hubert, Anbesu, Etsay Woldu, Ancuceanu, Robert, Ansari, Fereshteh, Ansari-Moghaddam, Alireza, Antwi, Maxwell Hubert, Anvari, Davood, Anyasodor, Anayochukwu Edward, Aqeel, Muhammad, Arabloo, Jalal, Arab-Zozani, Morteza, Aremu, Olatunde, Ariffin, Hany, Aripov, Timur, Arshad, Muhammad, Artaman, Al, Arulappan, Judie, Asemi, Zatollah, Asghari Jafarabadi, Mohammad, Ashraf, Tahira, Atorkey, Prince, Aujayeb, Avinash, Ausloos, Marcel, Awedew, Atalel Fentahun, Ayala Quintanilla, Beatriz Paulina, Ayenew, Temesgen, Azab, Mohammed A., Azadnajafabad, Sina, Azari Jafari, Amirhossein, Azarian, Ghasem, Azzam, Ahmed Y., Badiye, Ashish D., Bahadory, Saeed, Baig, Atif Amin, Baker, Jennifer L., Balakrishnan, Senthilkumar, Banach, Maciej, Bärnighausen, Till Winfried, Barone-Adesi, Francesco, Barra, Fabio, Barrow, Amadou, Behzadifar, Masoud, Belgaumi, Uzma Iqbal, Bezabhe, Woldesellassie M. Mequanint, Bezabih, Yihienew Mequanint, Bhagat, Devidas S., Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhaskar, Sonu, Bhattacharyya, Krittika, Bhojaraja, Vijayalakshmi S., Bibi, Sadia, Bijani, Ali, Biondi, Antonio, Bisignano, Catherine, Bjørge, Tone, Bleyer, Archie, Blyuss, Oleg, Bolarinwa, Obasanjo Afolabi, Bolla, Srinivasa Rao, Braithwaite, Dejana, Brar, Amanpreet, Brenner, Hermann, Bustamante-Teixeira, Maria Teresa, Butt, Nadeem Shafique, Butt, Zahid A., Caetano dos Santos, Florentino Luciano, Cao, Yin, Carreras, Giulia, Catalá-López, Ferrán, Cembranel, Francieli, Cerin, Ester, Cernigliaro, Achille, Chakinala, Raja Chandra, Chattu, Soosanna Kumary, Chattu, Vijay Kumar, Chaturvedi, Pankaj, Chimed-Ochir, Odgerel, Cho, Daniel Youngwhan, Christopher, Devasahayam J., Chu, Dinh-Toi, Chung, Michael T., Conde, Joao, Cortés, Sanda, Cortesi, Paolo Angelo, Costa, Vera Marisa, Cunha, Amanda Ramos, Dadras, Omid, Dagnew, Amare Belachew, Dahlawi, Saad M. A., Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Darwesh, Aso Mohammad, das Neves, José, De la Hoz, Fernando Pio, Demis, Asmamaw Bizuneh, Denova-Gutiérrez, Edgar, Dhamnetiya, Deepak, Dhimal, Mandira Lamichhane, Dhimal, Meghnath, Dianatinasab, Mostafa, Diaz, Daniel, Djalalinia, Shirin, Do, Huyen Phuc, Doaei, Saeid, Dorostkar, Fariba, dos Santos Figueiredo, Francisco Winter, Driscoll, Tim Robert, Ebrahimi, Hedyeh, Eftekharzadeh, Sahar, El Tantawi, Maha, El-Abid, Hassan, Elbarazi, Iffat, Elhabashy, Hala Rashad, Elhadi, Muhammed, El-Jaafary, Shaimaa I., Eshrati, Babak, Eskandarieh, Sharareh, Esmaeilzadeh, Firooz, Etemadi, Arash, Ezzikouri, Sayeh, Faisaluddin, Mohammed, Faraon, Emerito Jose A., Fares, Jawad, Farzadfar, Farshad, Feroze, Abdullah Hamid, Ferrero, Simone, Ferro Desideri, Lorenzo, Filip, Irina, Fischer, Florian, Fisher, James L., Foroutan, Masoud, Fukumoto, Takeshi, Gaal, Peter Andras, Gad, Mohamed M., Gadanya, Muktar A., Gallus, Silvano, Gaspar Fonseca, Mariana, Getachew Obsa, Abera, Ghafourifard, Mansour, Ghashghaee, Ahmad, Ghith, Nermin, Gholamalizadeh, Maryam, Gilani, Syed Amir, Ginindza, Themba G., Gizaw, Abraham Tamirat T., Glasbey, James C., Golechha, Mahaveer, Goleij, Pouya, Gomez, Ricardo Santiago, Gopalani, Sameer Vali, Gorini, Giuseppe, Goudarzi, Houman, Grosso, Giuseppe, Gubari, Mohammed Ibrahim Mohialdeen, Guerra, Maximiliano Ribeiro, Guha, Avirup, Gunasekera, D. Sanjeeva, Gupta, Bhawna, Gupta, Veer Bala, Gupta, Vivek Kumar, Gutiérrez, Reyna Alma, Hafezi-Nejad, Nima, Haider, Mohammad Rifat, Haj-Mirzaian, Arvin, Halwani, Rabih, Hamadeh, Randah R., Hameed, Sajid, Hamidi, Samer, Hanif, Asif, Haque, Shafiul, Harlianto, Netanja I., Haro, Josep Maria, Hasaballah, Ahmed I., Hassanipour, Soheil, Hay, Roderick J., Hay, Simon I., Hayat, Khezar, Heidari, Golnaz, Heidari, Mohammad, Herrera-Serna, Brenda Yuliana, Herteliu, Claudiu, Hezam, Kamal, Holla, Ramesh, Hossain, Md Mahbub, Hossain, Mohammad Bellal Hossain, Hosseini, Mohammad-Salar, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hsairi, Mohamed, Huang, Junjie, Hugo, Fernando N., Hussain, Rabia, Hussein, Nawfal R., Hwang, Bing-Fang, Iavicoli, Ivo, Ibitoye, Segun Emmanuel, Ida, Fidelia, Ikuta, Kevin S., Ilesanmi, Olayinka Stephen, Ilic, Irena M., Ilic, Milena D., Irham, Lalu Muhammad, Islam, Jessica Y., Islam, Rakibul M., Islam, Sheikh Mohammed Shariful, Ismail, Nahlah Elkudssiah, Isola, Gaetano, Iwagami, Masao, Jacob, Louis, Jain, Vardhmaan, Jakovljevic, Mihajlo B., Javaheri, Tahereh, Jayaram, Shubha, Jazayeri, Seyed Behzad, Jha, Ravi Prakash, Jonas, Jost B., Joo, Tamas, Joseph, Nitin, Joukar, Farahnaz, Jürisson, Mikk, Kabir, Ali, Kahrizi, Danial, Kalankesh, Leila R., Kalhor, Rohollah, Kaliyadan, Feroze, Kalkonde, Yogeshwar, Kamath, Ashwin, Kameran Al-Salihi, Nawzad, Kandel, Himal, Kapoor, Neeti, Karch, André, Kasa, Ayele Semachew, Katikireddi, Srinivasa Vittal, Kauppila, Joonas H., Kavetskyy, Taras, Kebede, Sewnet Adem, Keshavarz, Pedram, Keykhaei, Mohammad, Khader, Yousef Saleh, Khalilov, Rovshan, Khan, Gulfaraz, Khan, Maseer, Khan, Md Nuruzzaman, Khan, Moien A. B., Khang, Young-Ho, Khater, Amir M., Khayamzadeh, Maryam, Kim, Gyu Ri, Kim, Yun Jin, Kisa, Adnan, Kisa, Sezer, Kissimova-Skarbek, Katarzyna, Kopec, Jacek A., Koteeswaran, Rajasekaran, Koul, Parvaiz A., Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Kucuk Bicer, Burcu, Kugbey, Nuworza, Kumar, G. Anil, Kumar, Narinder, Kumar, Nithin, Kurmi, Om P., Kutluk, Tezer, La Vecchia, Carlo, Lami, Faris Hasan, Landires, Iván, Lauriola, Paolo, Lee, Sang-woong, Lee, Shaun Wen Huey, Lee, Wei-Chen, Lee, Yo Han, Leigh, James, Leong, Elvynna, Li, Jiarui, Li, Ming-Chieh, Liu, Xuefeng, Loureiro, Joana A., Lunevicius, Raimundas, Magdy Abd El Razek, Muhammed, Majeed, Azeem, Makki, Alaa, Male, Shilpa, Malik, Ahmad Azam, Mansournia, Mohammad Ali, Martini, Santi, Masoumi, Seyedeh Zahra, Mathur, Prashant, McKee, Martin, Mehrotra, Ravi, Mendoza, Walter, Menezes, Ritesh G., Mengesha, Endalkachew Worku, Mesregah, Mohamed Kamal, Mestrovic, Tomislav, Miao Jonasson, Junmei, Miazgowski, Bartosz, Miazgowski, Tomasz, Michalek, Irmina Maria, Miller, Ted R., Mirzaei, Hamed, Mirzaei, Hamid Reza, Misra, Sanjeev, Mithra, Prasanna, Moghadaszadeh, Masoud, Mohammad, Karzan Abdulmuhsin, Mohammad, Yousef, Mohammadi, Mokhtar, Mohammadi, Seyyede Momeneh, Mohammadian-Hafshejani, Abdollah, Mohammed, Shafiu, Moka, Nagabhishek, Mokdad, Ali H., Molokhia, Mariam, Monasta, Lorenzo, Moni, Mohammad Ali, Moosavi, Mohammad Amin, Moradi, Yousef, Moraga, Paula, Morgado-da-Costa, Joana, Morrison, Shane Douglas, Mosapour, Abbas, Mubarik, Sumaira, Mwanri, Lillian, Nagarajan, Ahamarshan Jayaraman, Nagaraju, Shankar Prasad, Nagata, Chie, Naimzada, Mukhammad David, Nangia, Vinay, Naqvi, Atta Abbas, Narasimha Swamy, Sreenivas, Ndejjo, Rawlance, Nduaguba, Sabina O., Negoi, Ionut, Negru, Serban Mircea, Neupane Kandel, Sandhya, Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Niazi, Robina Khan, Nnaji, Chukwudi A., Noor, Nurulamin M., Nuñez-Samudio, Virginia, Nzoputam, Chimezie Igwegbe, Oancea, Bogdan, Ochir, Chimedsuren, Odukoya, Oluwakemi Ololade, Ogbo, Felix Akpojene, Olagunju, Andrew T., Olakunde, Babayemi Oluwaseun, Omar, Emad, Omar Bali, Ahmed, Omonisi, Abidemi E. Emmanuel, Ong, Sokking, Onwujekwe, Obinna E., Orru, Hans, Ortega-Altamirano, Doris V., Otstavnov, Nikita, Otstavnov, Stanislav S., Owolabi, Mayowa O., P A, Mahesh, Padubidri, Jagadish Rao, Pakshir, Keyvan, Pana, Adrian, Panagiotakos, Demosthenes, Panda-Jonas, Songhomitra, Pardhan, Shahina, Park, Eun-Cheol, Park, Eun-Kee, Pashazadeh Kan, Fatemeh, Patel, Harsh K., Patel, Jenil R., Pati, Siddhartha, Pattanshetty, Sanjay M., Paudel, Uttam, Pereira, David M., Pereira, Renato B., Perianayagam, Arokiasamy, Pillay, Julian David, Pirouzpanah, Saeed, Pishgar, Farhad, Podder, Indrashis, Postma, Maarten J., Pourjafar, Hadi, Prashant, Akila, Preotescu, Liliana, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Radhakrishnan, Raghu Anekal, Radhakrishnan, Venkatraman, Rafiee, Ata, Rahim, Fakher, Rahimzadeh, Shadi, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rajai, Nazanin, Rajesh, Aashish, Rakovac, Ivo, Ram, Pradhum, Ramezanzadeh, Kiana, Ranabhat, Kamal, Ranasinghe, Priyanga, Rao, Chythra R., Rao, Sowmya J., Rawassizadeh, Reza, Razeghinia, Mohammad Sadegh, Renzaho, Andre M. N., Rezaei, Negar, Rezaei, Nima, Rezapour, Aziz, Roberts, Thomas J., Rodriguez, Jefferson Antonio Buendia, Rohloff, Peter, Romoli, Michele, Ronfani, Luca, Roshandel, Gholamreza, Rwegerera, Godfrey M., S, Manjula, Sabour, Siamak, Saddik, Basema, Saeed, Umar, Sahebkar, Amirhossein, Sahoo, Harihar, Salehi, Sana, Salem, Marwa Rashad, Salimzadeh, Hamideh, Samaei, Mehrnoosh, Samy, Abdallah M., Sanabria, Juan, Sankararaman, Senthilkumar, Santric-Milicevic, Milena M., Sardiwalla, Yaeesh, Sarveazad, Arash, Sathian, Brijesh, Sawhney, Monika, Saylan, Mete, Schneider, Ione Jayce Ceola, Sekerija, Mario, Seylani, Allen, Shafaat, Omid, Shaghaghi, Zahra, Shaikh, Masood Ali, Shamsoddin, Erfan, Shannawaz, Mohammed, Sharma, Rajesh, Sheikh, Aziz, Sheikhbahaei, Sara, Shetty, Adithi, Shetty, Jeevan K., Shetty, Pavanchand H., Shibuya, Kenji, Shirkoohi, Reza, Shivakumar, K. M., Shivarov, Velizar, Siabani, Soraya, Siddappa Malleshappa, Sudeep K., Silva, Diego Augusto Santos, Singh, Jasvinder A., Sintayehu, Yitagesu, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Soeberg, Matthew J., Sofi-Mahmudi, Ahmad, Sotoudeh, Houman, Steiropoulos, Paschalis, Straif, Kurt, Subedi, Ranjeeta, Sufiyan, Mu'awiyyah Babale, Sultan, Iyad, Sultana, Saima, Sur, Daniel, Szerencsés, Viktória, Szócska, Miklós, Tabarés-Seisdedos, Rafael, Tabuchi, Takahiro, Tadbiri, Hooman, Taherkhani, Amir, Takahashi, Ken, Talaat, Iman M., Tan, Ker-Kan, Tat, Vivian Y., Tedla, Bemnet Amare A., Tefera, Yonas Getaye, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Tesfay, Fisaha Haile, Tessema, Gizachew Assefa, Thapar, Rekha, Thavamani, Aravind, Thoguluva Chandrasekar, Viveksandeep, Thomas, Nihal, Tohidinik, Hamid Reza, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Traini, Eugenio, Tran, Bach Xuan, Tran, Khanh Bao, Tran, Mai Thi Ngoc, Tripathy, Jaya Prasad, Tusa, Biruk Shalmeno, Ullah, Irfan, Ullah, Saif, Umapathi, Krishna Kishore, Unnikrishnan, Bhaskaran, Upadhyay, Era, Vacante, Marco, Vaezi, Maryam, Valadan Tahbaz, Sahel, Velazquez, Diana Zuleika, Veroux, Massimiliano, Violante, Francesco S., Vlassov, Vasily, Vo, Bay, Volovici, Victor, Vu, Giang Thu, Waheed, Yasir, Wamai, Richard G., Ward, Paul, Wen, Yi Feng, Westerman, Ronny, Winkler, Andrea Sylvia, Yadav, Lalit, Yahyazadeh Jabbari, Seyed Hossein, Yang, Lin, Yaya, Sanni, Yazie, Taklo Simeneh Yazie, Yeshaw, Yigizie, Yonemoto, Naohiro, Younis, Mustafa Z., Yousefi, Zabihollah, Yu, Chuanhua, Yuce, Deniz, Yunusa, Ismaeel, Zadnik, Vesna, Zare, Fariba, Zastrozhin, Mikhail Sergeevich, Zastrozhina, Anasthasia, Zhang, Jianrong, Zhong, Chenwen, Zhou, Linghui, Zhu, Cong, Ziapour, Arash, Zimmermann, Ivan R., Fitzmaurice, Christina, Murray, Christopher J. L., and Force, Lisa M.

Abstract

IMPORTANCE: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.

Published
2022
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221. Cuestiones actuales del derecho aéreo

Author

LEBRÓN, MARÍA JESÚS GUERRERO, Coord., Lavall, María Victoria Petit, Folchi, Mario O., Zampone, Alessandro, de Riduan, Llamal Bencharki, Bocchese, Donatella, Cangelosi, Gabriella, Marchiafava, Giovanni, Orrù, Elena, Meza, Diana Paola Rubiano, Caballero, Alfonso Llorente, Piras, Massimiliano, Pinto, Michele M. Comenale, Álvarez, Belén García, Tapia, Belén Ferrer, Delgado, Juan Pablo Rodríguez, Barros, Ángel M.ª Ballesteros, Oria, Blanca Bago, Liso, Lourdes Moreno, Méndez, Jorge Álvarez, Puetz, Achim, LEBRÓN, MARÍA JESÚS GUERRERO, Lavall, María Victoria Petit, Folchi, Mario O., Zampone, Alessandro, de Riduan, Llamal Bencharki, Bocchese, Donatella, Cangelosi, Gabriella, Marchiafava, Giovanni, Orrù, Elena, Meza, Diana Paola Rubiano, Caballero, Alfonso Llorente, Piras, Massimiliano, Pinto, Michele M. Comenale, Álvarez, Belén García, Tapia, Belén Ferrer, Delgado, Juan Pablo Rodríguez, Barros, Ángel M.ª Ballesteros, Oria, Blanca Bago, Liso, Lourdes Moreno, Méndez, Jorge Álvarez, and Puetz, Achim

Published
2012
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222. Morphodynamics of coastal areas represented in the new geomorphologic map of Italy: draw the landforms of the past to outline the future

Author

Chelli, A., Aringoli, D., Aucelli, P., Baldassarre, M. A., Bellotti, P., Bini, M., Biolchi, S., Bontempi, S., Brandolini, P., Davoli, L., Deiana, G., DE MURO, S., Devoto, S., DI PAOLA, G., Donadio, C., Fago, P., Ferrari, M., Furlani, S., Ibba, A., LUPIA PALMIERI, E., Marsico, A., Mastronuzzi, G. MELIS R. T., Milella, M., Mucerino, L., Nesci, O., Orru’, P. E., Panizza, V., Pennetta, M., Piacentini, D., Piscitelli, A., Pusceddu, N., Raffi, R., Rosskopf, C. M., Sanso’, P., Stanislao, C., Tarragoni, C., and Valente, A.

Published
2018

223. Mortality risk attributable to wildfire-related PM2·5pollution: a global time series study in 749 locations

Author

Chen, Gongbo, Guo, Yuming, Yue, Xu, Tong, Shilu, Gasparrini, Antonio, Bell, Michelle L, Armstrong, Ben, Schwartz, Joel, Jaakkola, Jouni J K, Zanobetti, Antonella, Lavigne, Eric, Nascimento Saldiva, Paulo Hilario, Kan, Haidong, Royé, Dominic, Milojevic, Ai, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Samoli, Evangelia, Mayvaneh, Fatemeh, Sera, Francesco, Carrasco-Escobar, Gabriel, Lei, Yadong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Teixeira, João Paulo, Madureira, Joana, Katsouyanni, Klea, Hurtado-Díaz, Magali, Maasikmets, Marek, Ragettli, Martina S, Hashizume, Masahiro, Stafoggia, Massimo, Pascal, Mathilde, Scortichini, Matteo, de Sousa Zanotti Stagliorio Coêlho, Micheline, Valdés Ortega, Nicolás, Ryti, Niilo R I, Scovronick, Noah, Matus, Patricia, Goodman, Patrick, Garland, Rebecca M, Abrutzky, Rosana, Garcia, Samuel Osorio, Rao, Shilpa, Fratianni, Simona, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Guo, Yue Leon, Ye, Tingting, Yu, Wenhua, Abramson, Michael J, Samet, Jonathan M, and Li, Shanshan

Abstract

Many regions of the world are now facing more frequent and unprecedentedly large wildfires. However, the association between wildfire-related PM2·5and mortality has not been well characterised. We aimed to comprehensively assess the association between short-term exposure to wildfire-related PM2·5and mortality across various regions of the world.

Published
2021
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224. Feasibility studies for a Mediterranean neutrino observatory — the NEMO.RD Project

Author

De Marzo, C., Ambriola, M., Bellotti, R., Cafagna, F., Calicchio, M., Ciacio, F., Circella, M., Montaruli, T., Falchieri, D., Gabrielli, A., Gandolfi, E., Masetti, M., Vitullo, C., Zanarini, G., Habel, R., Usai, I., Aiello, S., Burrafato, G., Caponetto, L., Costanzo, E., LoPresti, D., Pappalardo, L., Petta, C., Randazzo, N., Russo, G.V., Troia, O., Barnà, R., D'Amico, V., De Domenico, E., De Pasquale, D., Giacobbe, S., Italiano, A., Migliardo, F., Salvato, G., Trafirò, A., Trimarchi, M., Ameli, F., Bonori, M., Bottai, S., Capone, A., Desiati, P., Massa, F., Masullo, R., Salusti, E., Vicini, M., Coniglione, R., Migneco, E., Piattelli, P., Riccobene, R., Sapienza, P., Cordelli, M., Trasatti, L., Valente, V., De Marchis, G., Piccari, L., Accerboni, E., Mosetti, R., Astraldi, M., Gasparini, G.P., Ulzega, A., and Orrù, P.

Published
2000
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225. Evaluation of the pulmonary and muscle oxygen kinetics in heart failure patients with reduced and preserved ejection fraction

Author

Gerson Cipriano Junior, G C J, Gaspar R Chiappa, G R C, Luz Goulart, C, Marianne Lucena Da Silva, M L S, Edson Marcio Negrao, E M N, Luciana Bartolomei Orru Davila, L B O D, Sergio Henrique Rodolpho Ramalho, S H R R, Nadia Oliveira Gomes, N O G, Graziella F Bernardelli Cipriano, G F B C, Dominique Hansen, D H, and Lawrence Patrick Cahalin, L P C

Published
2024
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226. Molecular pathways triggered by COVID-19 in different organs: ACE2 receptor-expressing cells under attack? A review.

Author

SABA, L., GEROSA, C., FANNI, D., MARONGIU, F., LA NASA, G., CAOCCI, G., BARCELLONA, D., BALESTRIERI, A., COGHE, F., ORRU, G., CONI, P., PIRAS, M., LEDDA, F., SURI, J. S., RONCHI, A., D'ANDREA, F., CAU, R., CASTAGNOLA, M., and FAA, G.

Abstract

OBJECTIVE: In human pathology, SARS-CoV-2 utilizes multiple molecular pathways to determine structural and biochemical changes within the different organs and cell types. The clinical picture of patients with COVID-19 is characterized by a very large spectrum. The reason for this variability has not been clarified yet, causing the inability to make a prognosis on the evolution of the disease. MATERIALS AND METHODS: PubMed search was performed focusing on the role of ACE 2 receptors in allowing the viral entry into cells, the role of ACE 2 downregulation in triggering the tissue pathology or in accelerating previous disease states, the role of increased levels of Angiotensin II in determining endothelial dysfunction and the enhanced vascular permeability, the role of the dysregulation of the renin angiotensin system in COVID-19 and the role of cytokine storm. RESULTS: The pathological changes induced by SARS-CoV-2 infection in the different organs, the correlations between the single cell types targeted by the virus in the different human or gans and the clinical consequences, COVID-19 chronic pathologies in liver fibrosis, cardiac fibrosis and atrial arrhythmias, glomerulosclerosis and pulmonary fibrosis, due to the systemic fibroblast activation induced by angiotensin II are discussed. CONCLUSIONS: The main pathways involved showed different pathological changes in multiple tissues and the different clinical presentations. Even if ACE2 is the main receptor of SARS-CoV-2 and the main entry point into cells for the virus, ACE2 expression does not always explain the observed marked inter-individual variability in clinical presentation and outcome, evidencing the complexity of this disorder. The proper interpretation of the growing data available might allow to better classifying COVID-19 in human pathology. [ABSTRACT FROM AUTHOR]

Published
2020

227. Morphometry and elevation of the last interglacial tidal notches in tectonically stable coasts of the Mediterranean Sea

Author

Antonioli, F., Ferranti, L., Stocchi, P., Deiana, G., Lo Presti, V., Furlani, S., Marino, C., Orru, P., Scicchitano, G., Trainito, E., Anzidei, M., Bonamini, M., Sansò, P., Mastronuzzi, G., Antonioli, F., Ferranti, L., Stocchi, P., Deiana, G., Lo Presti, V., Furlani, S., Marino, C., Orru, P., Scicchitano, G., Trainito, E., Anzidei, M., Bonamini, M., Sansò, P., and Mastronuzzi, G.

Abstract

We report detailed morphometric observations on several MIS 5.5 and a few older (MIS 11, 21, 25) fossil tidal notches shaped along carbonate coasts at 80 sites in the central Mediterranean Sea and at an additional six sites in the eastern and western Mediterranean. At each site, we performed precise measurements of the fossil tidal notch (FTN) width and depth, and of the elevation of its base relative to the base of the present tidal notch (PTN). The age of the fossil notches is obtained by correlation with biologic material associated with the notches at or very close to the site. This material was previously dated either through radiometric analysis or by its fossiliferous content.The width (i.e. the difference in elevation between base and top) of the notches ranges from 1.20 to 0.38 m, with a mean of 0.74 m. Although the FTN is always a few centimetres wider than the PTN, probably because of the lack of the biological reef coupled with a small erosional enlargement in the FTN, the broadly comparable width suggests that tide amplitude has not changed since MIS 5.5 times. This result can be extended to the MIS 11 features because of a comparable notch width, but not to the MIS 21 and 25 epochs. Although observational control of these older notches is limited, we regard this result as suggesting that changes in tide amplitude broadly occurred at the Early-Middle Pleistocene transition.The investigated MIS 5.5 notches are located in tectonically stable coasts, compared to other sectors of the central Mediterranean Sea where they are uplifted or subsided to ~100 m and over. In these stable areas, the elevation of the base of the MIS 5.5 notch ranges from 2.09 to 12.48 m, with a mean of 5.7 m. Such variability, although limited, indicates that small land movements, deriving from slow crustal processes, may have occurred in stable areas. We defined a number of sectors characterized by different geologic histories, where a careful evaluation of local vertical land motio

Published
2018

228. Global, regional, and national burden of mortality associated with non-optimal ambient temperatures from 2000 to 2019: a three-stage modelling study

Author

Zhao, Qi, Guo, Yuming, Ye, Tingting, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Dung, Do Van, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Di Ruscio, Francesco, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J K, Katsouyanni, Klea, Hurtado Diaz, Magali, Ragettli, Martina S, Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Valdés Ortega, Nicolás, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Matus Correa, Patricia, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Rao, Shilpa, Fratianni, Simona, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Guo, Yue Leon, Bell, Michelle L, and Li, Shanshan

Abstract

Exposure to cold or hot temperatures is associated with premature deaths. We aimed to evaluate the global, regional, and national mortality burden associated with non-optimal ambient temperatures.

Published
2021
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229. Acute Myelopathy

Author

McEntire, Caleb R., Dowd, Richard S., Orru’, Emanuele, David, Carlos, Small, Juan E., Cervantes-Arslanian, Anna, and Lerner, David P.

Abstract

Vascular and infectious causes are rare but important causes of spinal cord injury. High suspicion for these processes is necessary, as symptoms may progress over hours to days, resulting in delayed presentation and diagnosis and worse outcomes. History and clinical examination findings can assist with localization of the affected vascular territory and spinal level, which will assist with focusing spinal imaging. Open and/or endovascular surgical management depends on the associated vascular abnormality. Infectious myelopathy treatment consists of targeted antimicrobial therapy when possible, infectious source control, and again, close monitoring for systemic complications.

Published
2021
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231. The geomorphological map of the Italian coast: from a descriptive to a morphodynamic approach

Author

Mastronuzzi, G., Aringoli, D., Aucelli, P., Baldassarre, M. A., Bellotti, P., Bini, M., Biolchi, S., Bontempi, S., Brandolini, P., Chelli, A., Davoli, L., Deiana, G., DE MURO, S., Devoto, S., DI PAOLA, G., Donadio, C., Fago, P., Ferrari, M., Furlani, S., Ibba, A., LUPIA PALMIERI, E., Marsico, A., Melis, R. T., Milella, M., Mucerino, L., Nesci, O., Orru’, P. E., Panizza, V., Pennetta, M., Piacentini, D., Piscitelli, A., Pusceddu, N., Raffi, R., Rosskopf, C. M., Sanso’, P., Stanislao, C., Tarragoni, C., and Valente, A.

Subjects
coastal dynamics, coastal morphology, coastal dynamics, coastal morphology, cartography, cartography
Published
2017

233. Hearing loss prevalence and years lived with disability, 1990–2019: findings from the Global Burden of Disease Study 2019

Author

Haile, Lydia M, Kamenov, Kaloyan, Briant, Paul Svitil, Orji, Aislyn U, Steinmetz, Jaimie D, Abdoli, Amir, Abdollahi, Mohammad, Abu-Gharbieh, Eman, Afshin, Ashkan, Ahmed, Haroon, Ahmed Rashid, Tarik, Akalu, Yonas, Alahdab, Fares, Alanezi, Fahad Mashhour, Alanzi, Turki M, Al Hamad, Hanadi, Ali, Liaqat, Alipour, Vahid, Al-Raddadi, Rajaa M, Amu, Hubert, Arabloo, Jalal, Arab-Zozani, Morteza, Arulappan, Judie, Ashbaugh, Charlie, Atnafu, Desta Debalkie, Babar, Zaheer-Ud-Din, Baig, Atif Amin, Banik, Palash Chandra, Bärnighausen, Till Winfried, Barrow, Amadou, Bender, Rose G, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bibi, Sadia, Bijani, Ali, Burkart, Katrin, Cederroth, Christopher R, Charan, Jaykaran, Choudhari, Sonali Gajanan, Chu, Dinh-Toi, Couto, Rosa A S, Dagnew, Amare Belachew, Dagnew, Baye, Dahlawi, Saad M A, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Desalew, Assefa, Dhamnetiya, Deepak, Dhimal, Mandira Lamichhane, Dhimal, Meghnath, Doyle, Kerrie E, Duncan, Bruce B, Ekholuenetale, Michael, Filip, Irina, Fischer, Florian, Franklin, Richard Charles, Gaidhane, Abhay Motiramji, Gaidhane, Shilpa, Gallus, Silvano, Ghamari, Farhad, Ghashghaee, Ahmad, Ghozali, Ghozali, Gilani, Syed Amir, Glavan, Ionela-Roxana, Golechha, Mahaveer, Goulart, Bárbara Niegia Garcia, Gupta, Veer Bala, Gupta, Vivek Kumar, Hamidi, Samer, Hammond, Billy Randall, Hay, Simon I, Hayat, Khezar, Heidari, Golnaz, Hoffman, Howard J, Hopf, Kathleen Pillsbury, Hosseinzadeh, Mehdi, Househ, Mowafa, Hussain, Rabia, Hwang, Bing-Fang, Iavicoli, Ivo, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Iwagami, Masao, Jacob, Louis, Jayapal, Sathish Kumar, Jha, Ravi Prakash, Jonas, Jost B, Kalhor, Rohollah, Kameran Al-Salihi, Nawzad, Kandel, Himal, Kasa, Ayele Semachew, Kayode, Gbenga A, Khalilov, Rovshan, Khan, Ejaz Ahmad, Khatib, Mahalaqua Nazli, Kosen, Soewarta, Koyanagi, Ai, Kumar, G Anil, Landires, Iván, Lasrado, Savita, Lim, Stephen S, Liu, Xuefeng, Lobo, Stany W, Lugo, Alessandra, Makki, Alaa, Mendoza, Walter, Mersha, Amanual Getnet, Mihretie, Kebadnew Mulatu, Miller, Ted R, Misra, Sanjeev, Mohamed, Teroj Abdulrahman, Mohammadi, Mokhtar, Mohammadian-Hafshejani, Abdollah, Mohammed, Arif, Mokdad, Ali H, Moni, Mohammad Ali, Neupane Kandel, Sandhya, Nguyen, Huong Lan Thi, Nixon, Molly R, Noubiap, Jean Jacques, Nuñez-Samudio, Virginia, Oancea, Bogdan, Oguoma, Victor Maduabuchi, Olagunju, Andrew T, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Orru, Hans, Owolabi, Mayowa O, Padubidri, Jagadish Rao, Pakshir, Keyvan, Pardhan, Shahina, Pashazadeh Kan, Fatemeh, Pasovic, Maja, Pawar, Shrikant, Pham, Hai Quang, Pinheiro, Marina, Pourshams, Akram, Rabiee, Navid, Rabiee, Mohammad, Radfar, Amir, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahman, Mohammad Hifz Ur, Rahman, Mosiur, Rahmani, Amir Masoud, Rana, Juwel, Rao, Chythra R, Rao, Sowmya J, Rashedi, Vahid, Rawaf, David Laith, Rawaf, Salman, Renzaho, Andre M N, Rezapour, Aziz, Ripon, Rezaul Karim, Rodrigues, Voilet, Rustagi, Neeti, Saeed, Umar, Sahebkar, Amirhossein, Samy, Abdallah M, Santric-Milicevic, Milena M, Sathian, Brijesh, Satpathy, Maheswar, Sawhney, Monika, Schlee, Winfried, Schmidt, Maria Inês, Seylani, Allen, Shaikh, Masood Ali, Shannawaz, Mohammed, Shiferaw, Wondimeneh Shibabaw, Siabani, Soraya, Singal, Anjali, Singh, Jasvinder A, Singh, Jitendra Kumar, Singhal, Deepika, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sotoudeh, Houman, Spurlock, Emma Elizabeth, Taddele, Biruk Wogayehu, Tamiru, Animut Tagele, Tareque, Md Ismail, Thapar, Rekha, Tovani-Palone, Marcos Roberto, Tran, Bach Xuan, Ullah, Saif, Valadan Tahbaz, Sahel, Violante, Francesco S, Vlassov, Vasily, Vo, Bay, Vongpradith, Avina, Vu, Giang Thu, Wei, Jingkai, Yadollahpour, Ali, Yahyazadeh Jabbari, Seyed Hossein, Yeshaw, Yigizie, Yigit, Vahit, Yirdaw, Birhanu Wubale, Yonemoto, Naohiro, Yu, Chuanhua, Yunusa, Ismaeel, Zamani, Mohammad, Zastrozhin, Mikhail Sergeevich, Zastrozhina, Anasthasia, Zhang, Zhi-Jiang, Zhao, Jeff T, Murray, Christopher J L, Davis, Adrian C, Vos, Theo, and Chadha, Shelly

Abstract

Hearing loss affects access to spoken language, which can affect cognition and development, and can negatively affect social wellbeing. We present updated estimates from the Global Burden of Disease (GBD) study on the prevalence of hearing loss in 2019, as well as the condition's associated disability.

Published
2021
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235. International teleproctoring in neurointerventional surgery and its potential impact on clinical trials in the era of COVID-19: legal and technical considerations

Author

Orru', Emanuele, Marosfoi, Miklos, Patel, Neil V, Coon, Alexander L, Wald, Christoph, Repucci, Nicholas, Nicholson, Patrick, Pereira, Vitor M, and Wakhloo, Ajay K

Abstract

BackgroundExisting travel restrictions limit the mobility of proctors, significantly delaying clinical trials and the introduction of new neurointerventional devices. We aim to describe in detail technical and legal considerations regarding international teleproctoring, a tool that could waive the need for in-person supervision during procedures.MethodsInternational teleproctoring was chosen to provide remote supervision during the first three intracranial aneurysm treatments with a new flow diverter (currently subject of a clinical trial) in the US. Real-time, high-resolution transmission software streamed audiovisual data to a proctor located in Canada. The software allowed the transmission of images in a de-identified, HIPAA-compliant manner.ResultsAll three flow diverters were implanted as desired by operator and proctor and without complication. The proctor could swap between images from multiple sources and reported complete spatial and situational awareness, without any significant lag or delay in communication. Procedural times and radiologic dose were similar to those of uncomplicated, routine flow diversion cases at our institution.ConclusionsInternational teleproctoring was successfully implemented in our clinical practice. Its first use provided important insights for establishing this tool in our field. With no clear horizon for lifting the current travel restrictions, teleproctoring has the potential to remove the need for proctor presence in the angiography suite, thereby allowing the field to advance through the continuation of trials and the introduction of new devices in clinical practice. In order for this tool to be used safely and effectively, highly reliable connection and high-resolution equipment is necessary, and multiple legal nuances have to be considered.

Published
2021
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237. Projections of excess mortality related to diurnal temperature range under climate change scenarios: a multi-country modelling study

Author

Lee, Whanhee, Kim, Yoonhee, Sera, Francesco, Gasparrini, Antonio, Park, Rokjin, Michelle Choi, Hayon, Prifti, Kristi, Bell, Michelle L, Abrutzky, Rosana, Guo, Yuming, Tong, Shilu, de Sousa Zanotti Stagliorio Coelho, Micheline, Nascimento Saldiva, Paulo Hilario, Lavigne, Eric, Orru, Hans, Indermitte, Ene, Jaakkola, Jouni J K, Ryti, Niilo R I, Pascal, Mathilde, Goodman, Patrick, Zeka, Ariana, Hashizume, Masahiro, Honda, Yasushi, Hurtado Diaz, Magali, César Cruz, Julio, Overcenco, Ala, Nunes, Baltazar, Madureira, Joana, Scovronick, Noah, Acquaotta, Fiorella, Tobias, Aurelio, Vicedo-Cabrera, Ana Maria, Ragettli, Martina S, Guo, Yue-Liang Leon, Chen, Bing-Yu, Li, Shanshan, Armstrong, Ben, Zanobetti, Antonella, Schwartz, Joel, and Kim, Ho

Abstract

Various retrospective studies have reported on the increase of mortality risk due to higher diurnal temperature range (DTR). This study projects the effect of DTR on future mortality across 445 communities in 20 countries and regions.

Published
2020
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238. Synthesis of Quinazolin-4-ones by Copper-Catalyzed Isocyanide Insertion

Author

Collet, Jurriën W., van der Nol, Edith A., Roose, Tom R., Maes, Bert U. W., Ruijter, Eelco, and Orru, Romano V. A.

Abstract

Herein, we report a novel copper-catalyzed imidoylative cross-coupling/cyclocondensation reaction between 2-isocyanobenzoates and amines efficiently producing quinazolin-4-ones. The reaction utilizes Cu(II) acetate as an environmentally benign catalyst in combination with a mild base and proceeds well in anisole, a recommended, sustainable solvent. Additionally, the reaction does not require dry conditions or inert atmospheres for optimal performance. The scope of this isocyanide insertion reaction is rather broad, tolerating various functionalized isocyanobenzoates and a range of substituted amines, although the use of aromatic amines as nucleophiles requires microwave heating.

Published
2020
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239. Synthesis of Densely Functionalized Pyrimidouracils by Nickel(II)-Catalyzed Isocyanide Insertion

Author

Collet, Jurriën W., Morel, Bénédicte, Lin, Hung-Chien, Roose, Thomas R., Mampuys, Pieter, Orru, Romano V. A., Ruijter, Eelco, and Maes, Bert U. W.

Abstract

A robust nickel-catalyzed oxidative isocyanide insertion/C–H amination by reaction of readily available N-uracil-amidines with isocyanides affording polysubstituted pyrimidouracils has been reported. The reaction proceeds in moderate to quantitative yield, under mild conditions (i.e., greensolvent, air atmosphere, moderate temperature). The broad range of structurally diverse isocyanides and N-uracil-amidines that are tolerated make this method an interesting alternative to the currently available procedures toward pyrimidouracils.

Published
2020
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242. Regular Wine Consumption in Chronic Heart Failure: Impact on Outcomes, Quality of Life, and Circulating Biomarkers

Author

Cosmi, Franco, Di Giulio, Paola, Masson, Serge, Finzi, Andrea, Marfisi, Rosa Maria, Cosmi, Deborah, Scarano, Marco, Tognoni, Gianni, Maggioni, Aldo P., Porcu, Maurizio, Boni, Silvana, Cutrupi, Giovanni, Tavazzi, Luigi, Latini, Roberto Tavazzi, L, Tognoni, G, Barlera, S, Franzosi, Mg, Latini, R, Lucci, D, Maggioni, Ap, Marchioli, R, Nicolosi, Gl, Porcu, M, Yusuf, S, Camerini, F, Cohn, Jn, Decarli, A, Pitt, B, Sleight, P, Poole-Wilson, Pa, Geraci, E, Scherillo, M, Fabbri, G, Bartolomei, B, Bertoli, D, Cobelli, F, Fresco, C, Ledda, A, Levantesi, G, Opasich, C, Rusconi, F, Sinagra, G, Turazza, F, Volpi, A, Ceseri, M, Alongi, G, Atzori, A, Bambi, F, Bastarolo, D, Bianchini, F, Cangioli, I, Canu, V, Caporusso, C, Cenni, G, Cintelli, L, Cocchio, M, Confente, A, Fenicia, E, Friso, G, Gianfriddo, M, Grilli, G, Lazzaro, B, Lonardo, G, Luise, A, Nota, R, Orlando, M, Petrolo, R, Pierattini, C, Pierota, V, Provenzani, A, Quartuccio, V, Ragno, A, Serio, C, Spolaor, A, Tafi, A, Tellaroli, E, Ghio, S, Ghizzardi, E, Masson, S, Crociati, L, Rovere, Mt, Corra, U, Di Giulio, P, Finzi, A, Gorini, M, Gonzini, L, Milani, V, Orsini, G, Bianchini, E, Cabiddu, S, Cipressa, L, Cipressa, Ml, Di Bitetto, G, Ferri, B, Galbiati, L, Lorimer, A, Pera, C, Priami, P, Rossi, Mg, Pasotti, E, Vaghi, F, Roncarolo, P, Zunino, Mt, Matta, F, Actis, E, Gaita, F, Azzaro, G, Zanetta, M, Paino, Am, Parravicini, U, Vegis, D, Conte, R, Ferraro, P, De Bernardi, A, Morelloni, S, Fagnani, M, Lucchina, Pg, Montagna, L, Bellone, E, Sappe, D, Ferraro, F, Delucchi, M, Reynaud, Sg, Dore, M, La, A, Massobrio, N, Bo, L, Trinchero, R, Imazio, M, Brocchi, G, Nejrotti, A, Rissone, L, Gabasio, S, Zocchi, C, Randazzo, S, Crenna, A, Giannuzzi, P, Bonanomi, E, Mezzani, A, De Marchi, M, Begliuomini, G, Gianonatti, Ca, Gavazzi, A, Grosu, A, Cas, Ld, Nodari, S, Garyfallidis, P, Bertoletti, A, Bonifazi, C, Arisi, S, Mascaro, F, Fraccarollo, M, Dell, S, Sfolcini, M, Bortolini, F, Raccagni, D, Turelli, A, Santarone, M, Miglierina, E, Sormani, L, Jemoli, R, Tettamanti, F, Pirelli, S, Bianchi, C, Verde, S, Mariani, M, Ziacchi, V, Ferrazza, A, Russo, A, Bortolotti, M, Pasini, Gf, Jones, Kn, Cuzzucrea, D, Gullace, G, Carbone, C, Granata, A, De, S, Del Rosso, G, Inserra, C, Renaldini, E, Zappa, C, Moretti, M, Zanini, R, Ferrari, M, Cei, A, Lissi, C, Dovico, E, Fiorentini, C, Palermo, P, Brusoni, B, Negrini, M, Heyman, J, Danzi, Gb, Frigerio, M, Beretta, L, Sachero, A, Casazza, F, Squadroni, L, Lombardi, F, Marano, L, Margonato, A, Fragasso, G, Febo, Oc, Aiolfi, E, Olmetti, F, Grieco, A, Antonazzo, V, Specchia, G, Mortara, A, Robustelli, F, Songini, Mg, Schweiger, C, Frisinghelli, A, Palvarini, M, Campana, C, Scelsi, L, Marsan, Na, Gualco, A, De Feo, S, Iannone, Ma, Diaco, T, Zaniboni, D, Milanesi, G, Nassiacos, D, Meloni, S, Giani, P, Nicoli, T, Malinverni, C, Gusmini, A, Pozzoni, L, Bisiani, G, Margaroli, P, Schizzarotto, A, Daverio, A, Morelli, E, Occhi, G, Partesana, N, Bandini, P, Rosella, Mg, Giustiniani, S, Cucchi, G, Pedretti, R, Raimondo, R, Vaninetti, R, Fedele, A, Ghezzi, I, Rezzonico, E, Salerno, Ja, Morandi, F, Salvucci, F, Valenti, C, Graziano, G, Romano, M, Cimminiello, C, Mangone, I, Lombardo, M, Quorso, P, Marinoni, G, Breghi, M, Erckert, M, Dienstl, A, Mirante, G, Stefenelli, C, Cioffi, G, Buczkowska, E, Bonanome, A, Bazzanini, F, Parissenti, L, Serafini, C, Catania, G, Tarantini, L, Rigatelli, G, Boni, S, Pasini, A, Masini, E, Zampiero, Aa, Zanchetta, M, Franceschetto, L, Delise, P, Marcon, C, Sacchetta, A, Borgese, L, Artusi, L, Casolino, P, Corbara, F, Banzato, A, Barbiero, M, Aldegheri, Mp, Bazzucco, R, Crivellenti, G, Raviele, A, Zanella, C, Pascotto, P, Sarto, P, Milan, S, Barbieri, E, Girardi, P, Dalla, W, Mule, Jd, Di Sipio ML, Cazzin, R, Milan, D, Zonzin, P, Carraro, M, Rossi, R, Carbonieri, E, Rossi, I, Stritoni, P, Meneghetti, P, Risica, G, Tenderini, Pl, Vassanelli, C, Zanolla, L, Perini, G, Brighetti, G, Chiozza, R, Giuliano, G, Baldin, Mg, Gortan, R, Cesanelli, R, Piazza, R, Mos, L, Vriz, O, Pavan, D, Pascottini, G, Alberti, E, Werren, M, Solinas, L, Longaro, F, Fioretti, P, Albanese, Mc, Miani, D, Gianrossi, R, Pende, A, Rubartelli, P, Magaia, O, Caruso, D, Faraguti, As, Magliani, L, Miccoli, F, Guglielmino, G, Cantarelli, A, Orlandi, S, Vallebona, A, Pozzati, A, Brega, G, Pancaldi, Lg, Vandelli, R, Urbinati, S, Poci, Mg, Zoli, M, Costa, Gm, Guiducci, U, Zobbi, G, Tartagni, F, Tisselli, A, Gentili, A, Pieri, P, Cagnetta, E, Bendinelli, S, Barbieri, A, Conti, R, Ferrari, R, Merlini, F, Fucili, A, Moruzzi, P, Buia, E, Galvani, M, Ferrini, D, Baggioni, G, Yiannacopulu, P, Canè, G, Bonfiglioli, A, Zandomeneghi, R, Brugioni, L, Giannini, A, Di, R, Giuliani, M, Rusconi, L, Del Corso, P, Piovaccari, G, Bologna, F, Venturi, P, Melandri, F, Bagni, E, Bolognese, L, Perticucci, R, Zuppiroli, A, Nannini, M, Consoli, N, Petrone, P, Pipitò, C, Colombi, L, Bernardi, D, Mariani, Pr, Testa, R, Mazzinghi, F, Cosmi, F, Cosmi, D, Zipoli, A, Cecchi, A, Castelli, G, Ciaccheri, M, Mori, F, Pieri, F, Valoti, P, Chiarantini, D, Santoro, Gm, Minneci, C, Marchi, F, Milli, M, Zambaldi, G, Geri, Aa, Cipriani, M, Alessandri, M, Severi, S, Stefanelli, S, Comella, A, Poddighe, R, Digiorgio, A, Carluccio, M, Berti, S, Rizza, A, Bonatti, V, Molendi, V, Brancato, A, D'Aprile, N, Giappichini, G, Del Vecchio, S, Mantini, G, De Tommasi, F, Meucci, G, Cordoni, M, Bechi, S, Barsotti, L, Baldini, P, Romei, M, Scopelliti, G, Lauri, G, Pestelli, F, Furiozzi, F, Cocchieri, M, Severini, D, Patriarchi, F, Chiocchi, P, Buccolieri, M, Martinelli, S, Wee, A, Angelici, F, Bernardinangeli, M, Proietti, G, Biscottini, B, Panciarola, R, Marinacci, L, Perna, Gp, Gabrielli, D, Moraca, A, Moretti, L, Partemi, L, Gregori, G, Amici, R, Patteri, G, Capone, P, Savini, E, Morgagni, Gl, Paccaloni, L, Pezzuoli, F, Carincola, S, Papi, S, De Crescentini, S, Gerardi, P, Midi, P, Gallenzi, E, Pajes, G, Mancone, C, Di, V, Di Gennaro, M, Calcagno, S, Toscano, S, Antonicoli, S, Carta, F, Giorgi, G, Comito, F, Daniele, E, Goretti, Sm, Ciarla, O, Gelfo, Pg, Acquaviva, A, Testa, D, Testa, G, Pagliaro, Fa, Russo, F, Vetta, F, Marchese, I, Di, G, D'Ambrosio, A, Leggio, F, Del Sindaco, D, Lacchè, A, Avallone, A, Risa, Mp, Azzolini, P, Baldo, E, Giovannini, E, Pulignano, G, Tondo, C, Picchio, E, Biffani, E, Tanzi, P, Pozzar, F, Farnetti, F, Azzarito, M, Santini, M, Varveri, A, Ferraiuolo, G, Valtorta, C, Gaspardone, A, Barbato, G, Ceci, V, Aspromonte, N, Bellocci, F, Colizzi, C, Fedele, F, Perez, Fi, Galati, A, Rossetti, A, Mainella, A, Ciuffetta, D, Matteucci, C, Busi, G, De, A, Farina, G, Granatelli, A, Leone, F, Frasca, F, Castellani, G, Massaro, G, Mastrogiuseppe, G, Vacri, A, De Sanctis, F, Cioli, M, Di Luzio, S, Napoletano, C, Piccioni, Ll, De Simone, G, Ottaviano, A, Mazza, V, Spedaliere, C, Staniscia, Td, Calgione, E, De Marco, G, Chiacchio, T, Di, T, Romanzi, S, Salvatore, G, Golino, P, Palermo, A, Mascia, F, Vetrano, A, Vinciguerra, A, Caliendo, L, Longobardi, R, De Caro, G, Di Nola, R, Piemonte, F, Prinzi, D, De Rosa, P, De, V, Riello, F, Capuano, V, Vecchio, G, Landi, M, Amato, S, Garofalo, M, D'Avino, M, Sensale, P, Maiolica, O, Santoro, R, Caso, P, Miceli, D, Maurea, N, Bianchi, U, Crispo, C, Chiariello, M, Filardi, Pp, Russo, L, Capuano, N, Ungaro, G, Vergara, G, Scafuro, F, D'Angelo, G, Campaniello, C, Bottiglieri, P, Volpe, A, Battista, R, De Risi, L, Cardillo, G, Sibilio, G, Marino, Ap, Silvestri, F, Predotti, P, Iervoglini, A, De Matteis, C, Sarnicola, P, Matarazzo, Mm, Baldi, S, Iuliano, V, Astarita, C, Cuccaro, P, Liguori, A, Liguori, G, Gregorio, G, Petraglia, L, Antonelli, G, Amodio, G, De Luca, I, Franchini, G, Lenti, Ml, Cavallari, D, D'Agostino, C, Scalera, G, Altamura, Cm, Russo, M, Mascolo, Ar, Pettinati, G, Ciricugno, Sa, Scrutinio, D, Passantino, A, Mastrangelo, D, Di Masi, A, De, R, Cannone, M, Dibiase, F, Pensato, M, Loliva, F, Trapani, F, Panettieri, I, Leone, L, Di, M, Carrone, M, Gallone, V, Cocco, F, Costantini, M, Tritto, C, Cavalieri, F, Stella, L, Magliari, F, Callerame, M, De Giorgi, A, Pellegrino, L, Correra, M, Portulano, V, Nisi, Gl, Grassi, G, Cristallo, E, De Laura, D, Salerno, C, Fanelli, R, Villella, M, Pede, S, Renna, A, De Lorenzi, E, Urso, L, Lenti, V, Peluso, A, Baldi, N, Polimeni, G, Palma, P, Lauletta, R, Tagliamonte, E, Cirillo, T, Centonze, G, D'Alessandro, B, Truncellito, L, Mecca, D, Petruzzi, Ma, Coviello, Ro, Lopizzo, A, Chiaffitelli, M, Barbuzzi, S, Gubelli, S, Germinario, G, Cosentino, N, Mingrone, A, Vico, R, Borrello, G, Mazza, Ml, Cimino, R, Galasso, D, Cassadonte, F, Talarico, U, Perticone, F, Cassano, S, Catapano, F, Calemme, S, Feraco, E, Cloro, C, Misuraca, G, Caporale, R, Vigna, L, Spagnuolo, V, De Rosa, F, Spadafora, G, Zampaglione, G, Russo, R, Schipani, Fa, Ferragina, Af, Stranieri, D, Musca, G, Carpino, C, Bencardino, P, Raimondo, F, Musacchio, D, Pulitano, G, Ruggeri, A, Provenzano, A, Salituri, S, Musolino, M, Calandruccio, S, Marrari, A, Tripodi, E, Scali, R, Anastasio, L, Arone, A, Aragona, P, Donnangelo, L, Comito, Mg, Bilotta, F, Vaccaro, I, Rametta, R, Ventura, V, Bonvegna, A, Alì, A, Cinnirella, C, Raineri, M, Pompeo, F, Ingurgio, Nc, Carini, V, Coco, R, Giunta, G, Leonardi, G, Randazzo, V, Di Blasi, V, Tamburino, C, Russo, G, Mangiameli, S, Cardillo, R, Castelli, D, Inserra, V, Arena, A, Gulizia, Mm, Raciti, S, Rapisarda, G, Romano, R, Prestifilippo, P, Braschi, Gb, Ledda, G, Terrazzino, R, De Caro, M, Scilabra, G, Graffagnino, B, Grassi, R, Scimone, Gf, Vasquez, L, Coppolino, C, Casale, A, Castelli, M, D'Urso, G, D'Antonio, E, Presti, Ll, Badalamenti, E, Conti, P, Sanfilippo, N, Cirrincione, V, Cinà, Mt, Cusimano, G, Taormina, A, Giuliano, P, Bajardi, A, Mandala, V, Canonico, A, Geraci, G, Sabella, Fp, Enia, F, Floresta, Am, Cascio, Il, Gumina, D, Cavallaro, A, Piccione, G, Ferrante, R, Blandino, M, Iudicello, Ms, Mossuti, E, Romano, G, Lombardo, L, Monastra, P, Di Vincenzo, D, Orru, P, Muscas, F, Giardina, G, Corda, M, Locci, G, Podda, A, Ledda, M, Siddi, P, Lai, C, Pili, G, Mercuro, G, Mureddu, G, Ganau, A, Meloni, G, Poddighe, G, Sanna, G., Cosmi, Franco, Di Giulio, Paola, Masson, Serge, Finzi, Andrea, Marfisi, Rosa Maria, Cosmi, Deborah, Scarano, Marco, Tognoni, Gianni, Maggioni, Aldo P, Porcu, Maurizio, Boni, Silvana, Cutrupi, Giovanni, Tavazzi, Luigi, Latini, Roberto, on behalf of the GISSI-HF, Investigator, Margonato, Alberto, DI GIULIO, Paola, Maggioni, Aldo P., GISSI HF, Investigator, and Sinagra, Gianfranco

Subjects
Male, Health Status, Left, Wine, Comorbidity, Ventricular Function, Left, Health Statu, Quality of life, Risk Factors, Surveys and Questionnaires, Prevalence, Ventricular Function, Surveys and Questionnaire, Depression (differential diagnoses), Depression, Medicine (all), Middle Aged, Prognosis, biological marker, Italy, Female, Risk assessment, Cardiology and Cardiovascular Medicine, biological markers, Human, Cardiac function curve, Vasculitis, medicine.medical_specialty, Vasculiti, Alcohol Drinking, Prognosi, Lower risk, Risk Assessment, Internal medicine, medicine, Humans, Protective Factor, Aged, Heart Failure, business.industry, Risk Factor, Stroke Volume, Biomarker, quality of life, wine, aged, alcohol drinking, biomarkers, chronic disease, comorbidity, depression, female, heart failure, humans, italy, male, middle aged, prevalence, prognosis, protective factors, risk assessment, risk factors, stroke volume, surveys and questionnaires, vasculitis, ventricular function, left, health status, cardiology and cardiovascular medicine, Biomarkers, Chronic Disease, Protective Factors, Quality of Life, medicine.disease, Clinical trial, Heart failure, Physical therapy, business
Abstract

Background— Moderate, regular alcohol consumption is generally associated with a lower risk of cardiovascular events but data in patients with chronic heart failure are scarce. We evaluated the relations between wine consumption, health status, circulating biomarkers, and clinical outcomes in a large Italian population of patients with chronic heart failure enrolled in a multicenter clinical trial. Methods and Results— A brief questionnaire on dietary habits was administered at baseline to 6973 patients enrolled in the Gruppo Italiano per lo Studio della Sopravvivenza nell’Insufficienza Cardiaca-Heart Failure (GISSI-HF) trial. The relations between wine consumption, fatal and nonfatal clinical end points, quality of life, symptoms of depression, and circulating biomarkers of cardiac function and inflammation (in subsets of patients) were evaluated with simple and multivariable-adjusted statistical models. Almost 56% of the patients reported drinking at least 1 glass of wine per day. After adjustment, clinical outcomes were not significantly different in the predefined 4 groups of wine consumption. However, patients with more frequent wine consumption had a significantly better perception of health status (Kansas City Cardiomyopathy Questionnaire score, adjusted P P =0.01), and lower plasma levels of biomarkers of vascular inflammation (osteoprotegerin and C-terminal proendothelin-1, adjusted P P =0.01) after adjusting for possible confounders. Conclusions— We show for the first time in a large cohort of patients with chronic heart failure that moderate wine consumption is associated with a better perceived and objective health status, lower prevalence of depression, and less vascular inflammation, but does not translate into more favorable clinical 4-year outcomes. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT0033633.

Published
2015

249. First clinical experience with the new Surpass Evolve flow diverter: technical and clinical considerations

Author

Orru, Emanuele, Rice, Henry, De Villiers, Laetitia, Klostranec, Jesse M, Wakhloo, Ajay K, Coon, Alexander L, Radovanovic, Ivan, Kortman, Hans, Bhatia, Kartik Dev, Krings, Timo, and Pereira, Vitor M

Abstract

ObjectiveTo describe the results in patients treated with the Surpass Evolve (SE) device, the new generation of Surpass flow diverters.MethodsTwenty-five consecutive patients (20 women, average age 58 years), with anterior or posterior circulation aneurysms treated with SEs in two early-user centers, were included. Device properties and related technical properties, imaging and clinical follow-up data, and intraprocedural, early (<30 days) and delayed (>30 days) neurological complications, further divided into minor (silent/non-permanent) and major (permanent) complications, were recorded and analyzed.ResultsTwenty-nine SEs were successfully implanted in all subjects to treat 26 aneurysms using an 0.027" microcatheter with an average of 1.2 stents per patient. No intraprocedural thromboembolic or hemorrhagic complications were seen. At clinical follow-up, 24/25 (96%) patients had a modified Rankin Score of 0–2. Mortality was 0%. Imaging follow-up, available in 22/25 (88%) patients (median follow-up time 4 months), showed a complete aneurysm occlusion in 13/23 (57%) imaged lesions. Minor, transitory neurological deficits were recorded in 5/25 (20%) patients. One (4%) major complication was seen in one patient (4%) with a left-sided hemispheric stroke on postprocedural day 4 due to an acute stent thrombosis.ConclusionsPreliminary experience in patients demonstrates a good performance of the SE. This newly designed implant maintains the engineering characteristics of Surpass flow diverters, including precise placement due to its lower foreshortening and a high mesh density, yet can be deployed through a significantly lower-profile delivery system.

Published
2020
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250. Procedural success with radial access for carotid artery stenting: systematic review and meta-analysis

Author

Jaroenngarmsamer, Tanaporn, Bhatia, Kartik Dev, Kortman, Hans, Orru, Emanuele, and Krings, Timo

Abstract

BackgroundFemoral access is the traditional approach for endovascular carotid artery stenting. Radial access is increasingly used as an alternative approach due to its known anatomical advantages in patients with unfavorable aortic arch morphology via the femoral approach and its excellent access site safety profile. Our objective was to analyze procedural success using radial access for carotid artery stenting as reported in the literature.MethodsThree online databases were systematically searched following PRISMA guidelines for studies (n ≥20) using radial artery access for carotid artery stenting (1999–2018). Random-effects meta-analysis was used to pool the procedural success (successful stent placement with no requirement for crossover to femoral access), mortality, and complication rates associated with radial access.ResultsSeven eligible studies reported procedural success outcomes with a pooled meta-analysis rate of 90.8% (657/723; 95% CI 86.7% to 94.2%; I2=53.1%). Asymptomatic radial artery occlusion occurred in 5.9% (95% CI 4.1% to 8.0%; I2=0%) and forearm hematoma in 1.4% (95% CI 0.4% to 2.9%; I2=0%). Risk of minor stroke/transient ischemic attack was 1.9% (95% CI 0.6% to 3.8%; I2=42.3%) and major stroke was 1.0% (95% CI 0.4% to 1.8%; I2=0%). There were three deaths across the seven studies (0.6%; 95% CI 0.2% to 1.3%; I2=0%). The meta-analysis was limited by statistically significant heterogeneity for the primary outcome of procedural success.ConclusionRadial access for carotid artery stenting has a high procedural success rate with low rates of mortality, access site complications, and cerebrovascular complications. The potential benefits of this approach in patients with unfavorable aortic arch access should be explored in a prospective randomized trial.

Published
2020
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