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150,861 results on '"OHTA, A."'

201. The lymphocyte/monocyte ratio predicts the efficacy of isatuximab plus pomalidomide in multiple myeloma patients

Author

Shimazu, Yutaka, Kanda, Junya, Onda, Yoshiyuki, Fuchida, Shin-ichi, Ohta, Kensuke, Shimura, Yuji, Kosugi, Satoru, Yamamura, Ryosuke, Matsuda, Mitsuhiro, Hanamoto, Hitoshi, Adachi, Yoko, Anzai, Naoyuki, Hotta, Masaaki, Fukushima, Kentaro, Yagi, Hideo, Yoshihara, Satoshi, Tanaka, Yasuhiro, Takakuwa, Teruhito, Tanaka, Hirokazu, Shibayama, Hirohiko, Uoshima, Nobuhiko, Hosen, Naoki, Ito, Tomoki, Shimazaki, Chihiro, Matsumura, Itaru, Kuroda, Junya, Takaori-Kondo, Akifumi, and Hino, Masayuki

Published
2024
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204. BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses.

Author

Houston, Jack, Ohta, Midori, Gómez-Cavazos, J, Deep, Amar, Corbett, Kevin, Oegema, Karen, Lara-Gonzalez, Pablo, Kim, Taekyung, and Desai, Arshad

Subjects
APC/C, Bub1, Cdc20, Plk1, cell cycle, centromere, embryogenesis, kinetochore, mitosis, spindle assembly checkpoint, Animals, Anaphase-Promoting Complex-Cyclosome, Caenorhabditis elegans, Cdc20 Proteins, Cell Cycle Proteins, Centers for Disease Control and Prevention, U.S., Kinetochores, Mitosis, Spindle Apparatus, United States
Abstract

During mitosis, chromosomes assemble kinetochores to dynamically couple with spindle microtubules.1,2 Kinetochores also function as signaling hubs directing mitotic progression by recruiting and controlling the fate of the anaphase promoting complex/cyclosome (APC/C) activator CDC-20.3,4,5 Kinetochores either incorporate CDC-20 into checkpoint complexes that inhibit the APC/C or dephosphorylate CDC-20, which allows it to interact with and activate the APC/C.4,6 The importance of these two CDC-20 fates likely depends on the biological context. In human somatic cells, the major mechanism controlling mitotic progression is the spindle checkpoint. By contrast, progression through mitosis during the cell cycles of early embryos is largely checkpoint independent.7,8,9,10 Here, we first show that CDC-20 phosphoregulation controls mitotic duration in the C. elegans embryo and defines a checkpoint-independent temporal mitotic optimum for robust embryogenesis. CDC-20 phosphoregulation occurs at kinetochores and in the cytosol. At kinetochores, the flux of CDC-20 for local dephosphorylation requires an ABBA motif on BUB-1 that directly interfaces with the structured WD40 domain of CDC-20.6,11,12,13 We next show that a conserved STP motif in BUB-1 that docks the mitotic kinase PLK-114 is necessary for CDC-20 kinetochore recruitment and timely mitotic progression. The kinase activity of PLK-1 is required for CDC-20 to localize to kinetochores and phosphorylates the CDC-20-binding ABBA motif of BUB-1 to promote BUB-1-CDC-20 interaction and mitotic progression. Thus, the BUB-1-bound pool of PLK-1 ensures timely mitosis during embryonic cell cycles by promoting CDC-20 recruitment to the vicinity of kinetochore-localized phosphatase activity.

Published
2023

207. Near-field Imaging of Optical Resonances in Silicon Metasurfaces Using Photoelectron Microscopy

Author

Boehm, Alex, Gennaro, Sylvain D., Doiron, Chloe F., Beechem, Thomas E., Sinclair, Michael B., Brener, Igal, Sarma, Raktim, and Ohta, Taisuke

Subjects
Physics - Optics, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Precise control of light-matter interactions at the nanoscale lies at the heart of nanophotonics. Experimental examination at this length scale is challenging, however, since the corresponding electromagnetic near-field is often confined within volumes below the resolution of conventional optical microscopy. In semiconductor nanophotonics electromagnetic fields are further restricted within the confines of individual subwavelength resonators, limiting access to critical light-matter interactions in these structures. In this work, we demonstrate that photoelectron emission microscopy (PEEM) can be used for polarization resolved near-field spectroscopy and imaging of electromagnetic resonances supported by broken-symmetry silicon metasurfaces. We find that the photoemission results, enabled through an in-situ potassium surface layer, are consistent with full-wave simulations and far-field reflectance measurements across visible and near-infrared wavelengths. In addition, we uncover a polarization dependent evolution of collective resonances near the metasurface array edge taking advantage of the far-field excitation and full-field imaging of PEEM. Here, we deduce that coupling between eight resonators or more establishes the collective excitations of this metasurface. All told, we demonstrate that the high-spatial resolution hyperspectral imaging and far-field illumination of PEEM can be leveraged for the metrology of collective, non-local, optical resonances in semiconductor nanophotonic structures., Comment: 17 pages, 5 Figures, Supporting Information: 14 pages, 10 figures

Published
2023
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208. Open data from the third observing run of LIGO, Virgo, KAGRA and GEO

Author

The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abbott, R., Abe, H., Acernese, F., Ackley, K., Adhicary, S., Adhikari, N., Adhikari, R. X., Adkins, V. K., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akutsu, T., Albanesi, S., Alfaidi, R. A., Al-Jodah, A., Alléné, C., Allocca, A., Almualla, M., Altin, P. A., Amato, A., Amez-Droz, L., Amorosi, A., Anand, S., Ananyeva, A., Andersen, R., Anderson, S. B., Anderson, W. G., Andia, M., Ando, M., Andrade, T., Andres, N., Andrés-Carcasona, M., Andrić, T., Ansoldi, S., Antelis, J. M., Antier, S., Aoumi, M., Apostolatos, T., Appavuravther, E. Z., Appert, S., Apple, S. K., Arai, K., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Arogeti, M., Aronson, S. M., Arun, K. G., Asada, H., Ashton, G., Aso, Y., Assiduo, M., Melo, S. Assis de Souza, Aston, S. M., Astone, P., Aubin, F., AultONeal, K., Babak, S., Badalyan, A., Badaracco, F., Badger, C., Bae, S., Bagnasco, S., Bai, Y., Baier, J. G., Baiotti, L., Baird, J., Bajpai, R., Baka, T., Ball, M., Ballardin, G., Ballmer, S. W., Baltus, G., Banagiri, S., Banerjee, B., Bankar, D., Baral, P., Barayoga, J. C., Barber, J., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Barthelmy, S. D., Barton, M. A., Bartos, I., Basak, S., Basalaev, A., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Baylor, A. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Beirnaert, F., Bejger, M., Bell, A. S., Benedetto, V., Beniwal, D., Benoit, W., Bentley, J. D., Yaala, M. Ben, Bera, S., Berbel, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Beroiz, M., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Beveridge, D., Bevins, N., Bhandare, R., Bhandari, A. V., Bhardwaj, U., Bhatt, R., Bhattacharjee, D., Bhaumik, S., Bianchi, A., Bilenko, I. A., Bilicki, M., Billingsley, G., Bini, S., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boër, M., Bogaert, G., Boileau, G., Boldrini, M., Bolingbroke, G. N., Bonavena, L. D., Bondarescu, R., Bondu, F., Bonilla, E., Bonilla, G. S., Bonnand, R., Booker, P., Bork, R., Boschi, V., Bose, N., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Braglia, M., Branch, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Bucci, F., Buchanan, J., Bulashenko, O., Bulik, T., Bulten, H. J., Buonanno, A., Burtnyk, K., Buscicchio, R., Buskulic, D., Buy, C., Byer, R. L., Davies, G. S. Cabourn, Cabras, G., Cabrita, R., Cadonati, L., Caesar, S., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Santoro, G. Caneva, Cannavacciuolo, M., Cannon, K. C., Cao, H., Cao, Z., Capistran, L. A., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Carlassara, M., Carlin, J. B., Carpinelli, M., Carter, J. J., Carullo, G., Diaz, J. Casanueva, Casentini, C., Castaldi, G., Castro-Lucas, S. Y., Caudill, S., Cavaglià, M., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakalis, W., Subrahmanya, S. Chalathadka, Champion, E., Chan, C., Chan, C. L., Chandra, K., Chang, I. P., Chang, W., Chanial, P., Chao, S., Chapman-Bird, C., Charlton, E. L., Charlton, P., Chassande-Mottin, E., Chastain, L., Chatterjee, C., Chatterjee, Debarati, Chatterjee, Deep, Chaturvedi, M., Chaty, S., Chatziioannou, K., Chen, D., Chen, H., Chen, H. Y., Chen, J., Chen, K. H., Chen, X., Chen, Y. -R., Chen, Y., Cheng, H., Chessa, P., Cheung, H. Y., Chia, H. Y., Chiadini, F., Chiang, C-I., Chiang, C., Chiarini, G., Chiba, A., Chiba, R., Chierici, R., Chincarini, A., Chiofalo, M. L., Chiummo, A., Choudhary, S., Christensen, N., Chua, S. S. Y., Chung, K. W., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciobanu, A. A., Ciolfi, R., Clara, F., Clark, J. A., Clarke, T. A., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Codazzo, E., Cohadon, P. -F., Colleoni, M., Collette, C. G., Colombo, A., Colpi, M., Compton, C. M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Cornish, N. J., Corsi, A., Cortese, S., Coschizza, A. C., Cottingham, R., Coughlin, M. W., Coulon, J. -P., Countryman, S. T., Coupechoux, J. -F., Cousins, B., Couvares, P., Coward, D. M., Cowart, M. J., Cowburn, B. D., Coyne, D. C., Coyne, R., Craig, K., Creighton, J. D. E., Creighton, T. D., Criswell, A. W., Crockett-Gray, J. C. G., Croquette, M., Crowder, S. G., Cudell, J. R., Cullen, T. J., Cumming, A., Cummings, R., Cuoco, E., Curyło, M., Dabadie, P., Canton, T. Dal, Dall'Osso, S., Dálya, G., D'Angelo, B., Danilishin, S., D'Antonio, S., Danzmann, K., Darroch, K. E., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. H., Datta, Sayantani, Dattilo, V., Dave, I., Davenport, A., Davier, M., Davis, D., Davis, M. C., Daw, E. J., Dax, M., DeBra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Del Favero, V., De Lillo, F., De Lillo, N., Dell'Aquila, D., Del Pozzo, W., De Matteis, F., D'Emilio, V., Demos, N., Dent, T., Depasse, A., De Pietri, R., De Rosa, R., De Rossi, C., DeSalvo, R., De Simone, R., Dhurandhar, S., Diab, R., Diamond, P. Z., Díaz, M. C., Didio, N. A., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giorgio, C., Di Giovanni, F., Di Giovanni, M., Di Girolamo, T., Diksha, D., Di Lieto, A., Di Michele, A., Di Pace, S., Di Palma, I., Di Renzo, F., Divyajyoti, Dmitriev, A., Doctor, Z., Dohmen, E., Doleva, P. P., Donahue, L., D'Onofrio, L., Donovan, F., Dooley, K. L., Dooney, T., Doravari, S., Dorosh, O., Drago, M., Driggers, J. C., Drori, Y., Ducoin, J. -G., Dunn, L., Dupletsa, U., Durante, O., D'Urso, D., Duverne, P. -A., Dwyer, S. E., Eassa, C., Easter, P. J., Ebersold, M., Eckhardt, T., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eichholz, J., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Engelby, E., Engl, A. J., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etzel, T., Evans, C., Evans, M., Evans, T. M., Evstafyeva, T., Ewing, B. E., Fabrizi, F., Faedi, F., Fafone, V., Fair, H., Fairhurst, S., Fan, P. C., Fan, X., Farah, A. M., Farr, B., Farr, W. M., Fauchon-Jones, E. J., Favaro, G., Favata, M., Fays, M., Feicht, J., Fejer, M. M., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, A., Fiori, I., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fiumara, V., Flaminio, R., Fleischer, S. M., Fleming, L. S., Floden, E., Fong, H. K., Font, J. A., Fornal, B., Forsyth, P. W. F., Franke, A., Frasca, S., Frasconi, F., Freed, J. P., Frei, Z., Freise, A., Freitas, O., Frey, R., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fujimoto, Y., Fukunaga, I., Fulda, P., Fyffe, M., Gabbard, H. A., Gabella, W. E., Gadre, B. U., Gaglani, K., Gair, J. R., Gais, J., Galaudage, S., Gallardo, S., Gamba, R., Ganapathy, D., Ganguly, A., Gao, D., Gaonkar, S. G., Garaventa, B., Garcia-Bellido, J., García-Núñez, C., García-Quirós, C., Gardner, K. A., Gargiulo, J., Garufi, F., Gasbarra, C., Gateley, B., Gayathri, V., Gemme, G., Gennai, A., George, J., Gerberding, O., Gergely, L., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, Shaon, Ghosh, Shrobana, Ghosh, Tathagata, Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Giri, P., Gissi, F., Gkaitatzis, S., Glanzer, J., Gleckl, A. E., Glotin, F., Godfrey, J., Godwin, P., Goetz, E., Goetz, R., Golomb, J., Goncharov, B., González, G., Gosselin, M., Gouaty, R., Gould, D. W., Goyal, S., Grace, B., Grado, A., Graham, V., Granata, M., Granata, V., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Green, S., Green, S. R., Gretarsson, A. M., Gretarsson, E. M., Griffith, D., Griffiths, W. L., Griggs, H. L., Grignani, G., Grimaldi, A., Grote, H., Gruson, A. S., Guerra, D., Guetta, D., Guidi, G. M., Guimaraes, A. R., Gulati, H. K., Gulminelli, F., Gunny, A. M., Guo, H., Guo, Y., Gupta, Anchal, Gupta, Anuradha, Gupta, Ish, Gupta, N. C., Gupta, P., Gupta, S. K., Gurs, J., Gushima, Y., Gustafson, E. K., Gutierrez, N., Guzman, F., Haegel, L., Hain, G., Haino, S., Halim, O., Hall, E. D., Hamilton, E. Z., Hammond, G., Han, W. -B., Haney, M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O. A., Hansen, H., Hanson, J., Harada, R., Harder, T., Haris, K., Harmark, T., Harms, J., Harry, G. M., Harry, I. W., Hartwig, D., Haskell, B., Haster, C. -J., Hathaway, J. S., Haughian, K., Hayakawa, H., Hayama, K., Hayes, F. J., Healy, J., Heffernan, A., Heidmann, A., Heintze, M. C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A. F., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J. -S., Hennig, M., Henshaw, C., Vivanco, F. Hernandez, Heurs, M., Hewitt, A. L., Higginbotham, S., Hild, S., Hill, P., Himemoto, Y., Hines, A. S., Hirata, N., Hirose, C., Ho, J., Hochheim, S., Hofman, D., Hohmann, J. N., Holcomb, D. G., Holland, N. A., Holley-Bockelmann, K., Hollows, I. J., Holmes, Z. J., Holt, K., Holz, D. E., Hong, Q., Hornung, J., Hoshino, S., Hough, J., Hourihane, S., Howell, D., Howell, E. J., Hoy, C. G., Hoyland, D., Hsieh, B. -H., Hsieh, H. -F., Hsiung, C., Hsu, H., Hu, P., Hu, Q., Huang, H. -Y., Huang, Y. -J., Huang, Y., Huang, Y. T., Hübner, M. T., Huddart, A. D., Hughey, B., Hui, D. C. Y., Hui, V., Husa, S., Huttner, S. H., Huxford, R., Huynh-Dinh, T., Hyland, J., Iakovlev, A., Iandolo, G. A., Idzkowski, B., Iess, A., Inayoshi, K., Inoue, Y., Iorio, G., Iosif, P., Irwin, J., Isi, M., Ismail, M. A., Itoh, Y., Iyer, B. R., JaberianHamedan, V., Jacqmin, T., Jacquet, P. -E., Jadhav, S. J., Jadhav, S. P., Jain, D., Jain, T., James, A. L., Jan, A. Z., Jani, K., Janiurek, L., Janquart, J., Janssens, K., Janthalur, N. N., Jaraba, S., Jaranowski, P., Jarov, S., Jasal, P., Jaume, R., Javed, W., Jenkins, A. C., Jenner, K., Jennings, A., Jia, W., Jiang, J., Liu, Jian, Jin, H. -B., Johansmeyer, K., Johns, G. R., Johnson, N. A., Johnston, R., Johny, N., Jones, A. W., Jones, D. H., Jones, D. I., Jones, P., Jones, R., Joshi, P., Ju, L., Jung, K., Junker, J., Juste, V., Kajita, T., Kalaghatgi, C., Kalogera, V., Kamai, B., Kamiizumi, M., Kanda, N., Kandhasamy, S., Kang, G., Kanner, J. B., Kapadia, S. J., Kapasi, D. P., Karat, S., Karathanasis, C., Karki, S., Kasamatsu, D., Kas-danouche, Y. A., Kashyap, R., Kasprzack, M., Kastaun, W., Kato, J., Katsanevas, S., Katsavounidis, E., Katsuren, J. K., Katzman, W., Kaur, T., Kawabe, K., Kawazoe, K., Kéfélian, F., Keitel, D., Kellard, I., Kelley-Derzon, J., Kennington, J., Key, J. S., Khadka, S., Khalili, F. Y., Khan, S., Khanam, T., Khazanov, E. A., Khursheed, M., Kijbunchoo, N., Kim, C., Kim, J. C., Kim, K., Kim, M. H., Kim, P., Kim, S., Kim, W. S., Kim, Y. -M., Kimball, C., Kimura, N., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kiyota, T., Klimenko, S., Klinger, T., Knee, A. M., Knust, N., Kobayashi, Y., Koch, P., Koehlenbeck, S. M., Koekoek, G., Kohri, K., Kokeyama, K., Koley, S., Koliadko, N. D., Kolitsidou, P., Kolstein, M., Kondrashov, V., Kong, A. K. H., Kontos, A., Korobko, M., Kossak, R. V., Kouvatsos, N., Kovalam, M., Koyama, N., Kozak, D. B., Kranzhoff, L., Kranzhoff, S. L., Kringel, V., Krishnendu, N. V., Królak, A., Kuehn, G., Kuijer, P., Kukihara, M., Kulkarni, S., Kumar, A., Kumar, Praveen, Kumar, Prayush, Kumar, Rahul, Kumar, Rakesh, Kume, J., Kuns, K., Kuroyanagi, S., Kuwahara, S., Kwak, K., Lacaille, G., Lagabbe, P., Laghi, D., Lakkis, M. H., Lalande, E., Lalleman, M., Lamberts, A., Landry, M., Lane, B. B., Lang, R. N., Lange, J., Lantz, B., La Rana, A., La Rosa, I., Lartaux-Vollard, A., Lasky, P. D., Lawrence, J., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., LeBohec, S., Lecoeuche, Y. K., Lee, E., Lee, H. M., Lee, H. W., Lee, K., Lee, R. -L., Lee, R., Lee, S., Legred, I. N., Lehmann, J., Lehner, L., Lemaître, A., Lenti, M., Leonardi, M., Leonova, E., Leroy, N., Letendre, N., Lethuillier, M., Levesque, C., Levin, Y., Leyde, K., Li, A. K. Y., Li, K. L., Li, T. G. F., Li, X., Lin, C. -Y., Lin, E. T., Lin, F-K., Lin, F-L., Lin, F., Lin, H. L., Lin, H., Lin, L. C. -C., Linde, F., Linker, S. D., Littenberg, T. B., Liu, A., Liu, G. C., Llamas, F., Lo, R. K. L., Lo, T., London, L. T., Longo, A., Lopez, D., Portilla, M. Lopez, Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lott, T. P., Lough, J. D., Loughlin, H. A., Lousto, C. O., Lovelace, G., Lowry, M. J., Lück, H., Lumaca, D., Lundgren, A. P., Lung, Y., Lussier, A. W., Lynam, J. E., Ma, L., Ma, S., Ma'arif, M., Macas, R., MacInnis, M., Macleod, D. M., MacMillan, I. A. O., Macquet, A., Hernandez, I. Magaña, Magazzù, C., Magee, R. M., Maggiore, R., Magnozzi, M., Mahesh, M., Mahesh, S., Maini, M., Majorana, E., Makarem, C. N., Maliakal, S., Malik, A., Man, N., Mandic, V., Mangano, V., Mannix, B., Mansell, G. L., Mansingh, G., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Pina, D. Marín, Marion, F., Márka, S., Márka, Z., Markakis, C., Markosyan, A. S., Markowitz, A., Maros, E., Marquina, A., Marsat, S., Martelli, F., Martin, I. W., Martin, R. M., Martinez, B. B., Martinez, M., Martinez, V. A., Martinez, V., Martinovic, K., Martynov, D. V., Marx, E. J., Masalehdan, H., Mason, K., Masserot, A., Reid, M. Masso, Mastrodicasa, M., Mastrogiovanni, S., Mateu-Lucena, M., Matiushechkina, M., Matsunaga, K., Mavalvala, N., McCarthy, R., McClelland, D. E., McClincy, P. K., McCormick, S., McCuller, L., McGhee, G. I., McGinn, J., McIsaac, C., McIver, J., McLeod, A., McRae, T., McWilliams, S. T., Meacher, D., Mehmet, M., Mehta, A. K., Meijer, Q., Melatos, A., Mendell, G., Menendez-Vazquez, A., Menoni, C. S., Mercer, R. A., Mereni, L., Merfeld, K., Merilh, E. L., Merritt, J. D., Merzougui, M., Messenger, C., Messick, C., Meyers, P. M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Michimura, Y., Middleton, H., Mihaylov, D. P., Miller, A., Miller, A. L., Miller, B., Miller, S., Millhouse, M., Mills, J. C., Milotti, E., Minenkov, Y., Mio, N., Mir, Ll. M., Miravet-Tenés, M., Mishra, A., Mishra, C., Mishra, T., Mistry, T., Mitchell, A. L., Mitra, S., Mitrofanov, V. 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A., Steinlechner, J., Steinlechner, S., Stergioulas, N., StPierre, M., Strang, L. C., Stratta, G., Strong, M. D., Strunk, A., Sturani, R., Stuver, A. L., Suchenek, M., Sudhagar, S., Sueltmann, N., Sugiyama, T., Suh, H. G., Sullivan, A. G., Summerscales, T. Z., Sun, L., Sunil, S., Sur, A., Suresh, J., Sutton, P. J., Suzuki, Takamasa, Suzuki, Takanori, Swinkels, B. L., Syx, A., Szczepańczyk, M. J., Szewczyk, P., Tacca, M., Tagoshi, H., Tait, S. C., Takahashi, H., Takahashi, R., Takamori, A., Takano, S., Takeda, H., Takeda, M., Talbot, C. J., Talbot, C., Tamaki, M., Tamanini, N., Tanabe, D., Tanaka, K., Tanaka, T., Tanasijczuk, A. J., Tanioka, S., Tanner, D. B., Tao, D., Tao, L., Tapia, R. D., Martín, E. N. Tapia San, Tarafder, R., Taranto, C., Taruya, A., Tasson, J. D., Teloi, M., Tenorio, R., Terhune, J. E. S., Terkowski, L., Themann, H., Thirugnanasambandam, M. P., Thomas, L. M., Thomas, M., Thomas, P., Thomas, S., Thompson, J. E., Thondapu, S. R., Thorne, K. 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S., Wilken, D., Willetts, K., Williams, D., Williams, M. J., Williamson, A. R., Willis, J. L., Willke, B., Wipf, C. C., Woan, G., Woehler, J., Wofford, J. K., Wong, D., Wong, H. T., Wong, I. C. F., Wright, M., Wu, C., Wu, D. S., Wu, H., Wysocki, D. M., Xiao, L., Xu, V. A., Yadav, N., Yamada, T., Yamamoto, H., Yamamoto, K., Yamamoto, M., Yamamoto, T., Yamamoto, T. S., Yamashita, K., Yamazaki, R., Yang, F. W., Yang, K. Z., Yang, Y. -C., Yap, M. J., Yeeles, D. W., Yelikar, A. B., Yeung, T. Y., Yokoyama, J., Yokozawa, T., Yoo, J., Yu, Hang, Yu, Haocun, Yuzurihara, H., Zadrożny, A., Zannelli, A. J., Zanolin, M., Zeeshan, M., Zeidler, S., Zelenova, T., Zendri, J. -P., Zevin, M., Zhang, J., Zhang, L., Zhang, R., Zhang, T., Zhang, Y., Zhao, C., Zhao, Yue, Zhao, Yuhang, Zheng, Y., Zhong, H., Zhou, R., Zhu, X. J., Zhu, Z. -H., Zimmerman, A. B., Zucker, M. E., and Zweizig, J.

Subjects
General Relativity and Quantum Cosmology
Abstract

The global network of gravitational-wave observatories now includes five detectors, namely LIGO Hanford, LIGO Livingston, Virgo, KAGRA, and GEO 600. These detectors collected data during their third observing run, O3, composed of three phases: O3a starting in April of 2019 and lasting six months, O3b starting in November of 2019 and lasting five months, and O3GK starting in April of 2020 and lasting 2 weeks. In this paper we describe these data and various other science products that can be freely accessed through the Gravitational Wave Open Science Center at https://gwosc.org. The main dataset, consisting of the gravitational-wave strain time series that contains the astrophysical signals, is released together with supporting data useful for their analysis and documentation, tutorials, as well as analysis software packages., Comment: 27 pages, 3 figures

Published
2023
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209. Observation of Acoustically Induced Dressed States of Rare-Earth Ions

Author

Ohta, Ryuichi, Lelu, Gregoire, Xu, Xuejun, Inaba, Tomohiro, Hitachi, Kenichi, Taniyasu, Yoshitaka, Sanada, Haruki, Ishizawa, Atsushi, Tawara, Takehiko, Oguri, Katsuya, Yamaguchi, Hiroshi, and Okamoto, Hajime

Subjects
Physics - Optics, Condensed Matter - Mesoscale and Nanoscale Physics, Quantum Physics
Abstract

Acoustically induced dressed states of long-lived erbium ions in a crystal are demonstrated. These states are formed by rapid modulation of two-level systems via strain induced by surface acoustic waves whose frequencies exceed the optical linewidth of the ion ensemble. Multiple sidebands and the reduction of their intensities appearing near the surface are evidence of a strong interaction between the acoustic waves and the ions. This development allows for on-chip control of long-lived ions and paves the way to highly coherent hybrid quantum systems with telecom photons, acoustic phonons, and electrons.

Published
2023
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210. Point Cloud-based Proactive Link Quality Prediction for Millimeter-wave Communications

Author

Ohta, Shoki, Nishio, Takayuki, Kudo, Riichi, Takahashi, Kahoko, and Nagata, Hisashi

Subjects
Computer Science - Networking and Internet Architecture, Computer Science - Artificial Intelligence, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning, Electrical Engineering and Systems Science - Image and Video Processing
Abstract

This study demonstrates the feasibility of point cloud-based proactive link quality prediction for millimeter-wave (mmWave) communications. Previous studies have proposed machine learning-based methods to predict received signal strength for future time periods using time series of depth images to mitigate the line-of-sight (LOS) path blockage by pedestrians in mmWave communication. However, these image-based methods have limited applicability due to privacy concerns as camera images may contain sensitive information. This study proposes a point cloud-based method for mmWave link quality prediction and demonstrates its feasibility through experiments. Point clouds represent three-dimensional (3D) spaces as a set of points and are sparser and less likely to contain sensitive information than camera images. Additionally, point clouds provide 3D position and motion information, which is necessary for understanding the radio propagation environment involving pedestrians. This study designs the mmWave link quality prediction method and conducts realistic indoor experiments, where the link quality fluctuates significantly due to human blockage, using commercially available IEEE 802.11ad-based 60 GHz wireless LAN devices and Kinect v2 RGB-D camera and Velodyne VLP-16 light detection and ranging (LiDAR) for point cloud acquisition. The experimental results showed that our proposed method can predict future large attenuation of mmWave received signal strength and throughput induced by the LOS path blockage by pedestrians with comparable or superior accuracy to image-based prediction methods. Hence, our point cloud-based method can serve as a viable alternative to image-based methods.

Published
2023
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211. Impedance-matched High-overtone Bulk Acoustic Resonator

Author

Kurosu, Megumi, Hatanaka, Daiki, Ohta, Ryuichi, Yamaguchi, Hiroshi, Taniyasu, Yoshitaka, and Okamoto, Hajime

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Applied Physics
Abstract

A high-overtone bulk acoustic resonator (HBAR), in which a piezoelectric transducer is set on an acoustic cavity, has been attracting attention in both fundamental research and RF applications due to its scalability, high frequency, and high quality factor. The acoustic impedance matching in HBARs is crucial for efficient acoustic power transfer from the piezoelectric transducer to the cavity. However, impedance mismatch remains in most HBARs due to the metal layer insertion between the piezoelectric layer and cavity substrate. In this study, we fabricated a nearly impedance-matched high-quality HBAR using an epitaxial AlN piezoelectric layer directly grown on a conductive SiC cavity substrate with no metal layer insertion. The small impedance mismatch was verified from the variation in the free spectral range (FSR), which is comparable to the best value in previously reported HBARs. The experimentally obtained FSR spectra was greatly reproduced by using the Mason model. Broadband phonon cavity modes up to the K-band (26.5 GHz) were achieved by reducing the thickness of the AlN layer from 800 to 200 nm. The high figure of merit of $f\times\text{Q} \sim 1.3\times 10^{13}\ \textrm{Hz}$ at 10 GHz was also obtained. Our nearly impedance-matched high-quality HBAR will enable the development of RF applications, such as low-phase noise oscillators and acoustic filters, as well as research on high-frequency acoustic systems hybridized with electric, optical, and magnetic systems.

Published
2022
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212. Search for subsolar-mass black hole binaries in the second part of Advanced LIGO's and Advanced Virgo's third observing run

Author

The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abbott, R., Abe, H., Acernese, F., Ackley, K., Adhicary, S., Adhikari, N., Adhikari, R. X., Adkins, V. K., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akutsu, T., Albanesi, S., Alfaidi, R. A., Alléné, C., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Ando, M., Andrade, T., Andres, N., Andrés-Carcasona, M., Andrić, T., Ansoldi, S., Antelis, J. M., Antier, S., Apostolatos, T., Appavuravther, E. Z., Appert, S., Apple, S. K., Arai, K., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Arogeti, M., Aronson, S. M., Arun, K. G., Asada, H., Ashton, G., Aso, Y., Assiduo, M., Melo, S. Assis de Souza, Aston, S. M., Astone, P., Aubin, F., AultONeal, K., Babak, S., Badaracco, F., Badger, C., Bae, S., Bae, Y., Bagnasco, S., Bai, Y., Baier, J. G., Baird, J., Bajpai, R., Baka, T., Ball, M., Ballardin, G., Ballmer, S. W., Baltus, G., Banagiri, S., Banerjee, B., Bankar, D., Barayoga, J. C., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Barton, M. A., Bartos, I., Basak, S., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Beirnaert, F., Bejger, M., Belahcene, I., Bell, A. S., Benedetto, V., Beniwal, D., Benoit, W., Bentley, J. D., BenYaala, M., Bera, S., Berbel, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Beroiz, M., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Beveridge, D., Bhandare, R., Bhandari, A. V., Bhardwaj, U., Bhatt, R., Bhattacharjee, D., Bhaumik, S., Bianchi, A., Bilenko, I. A., Bilicki, M., Billingsley, G., Bini, S., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boër, M., Bogaert, G., Boldrini, M., Bolingbroke, G. N., Bonavena, L. D., Bondarescu, R., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Bork, R., Boschi, V., Bose, N., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branch, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Bucci, F., Buchanan, J., Bulik, T., Bulten, H. J., Buonanno, A., Burtnyk, K., Buscicchio, R., Buskulic, D., Buy, C., Byer, R. L., Davies, G. S. Cabourn, Cabras, G., Cabrita, R., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Caneva, G., Cannavacciuolo, M., Cannon, K. C., Cao, H., Cao, Z., Capistran, L. A., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Carlassara, M., Carlin, J. 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K., Posnansky, C., Poulton, R., Powell, J., Pracchia, M., Pradier, T., Prajapati, A. K., Prasai, K., Prasanna, R., Pratten, G., Principe, M., Prodi, G. A., Prokhorov, L., Prosposito, P., Prudenzi, L., Puecher, A., Punturo, M., Puosi, F., Puppo, P., Pürrer, M., Qi, H., Quartey, N., Quetschke, V., Quinonez, P. J., Quitzow-James, R., Raab, F. J., Raaijmakers, G., Radkins, H., Radulesco, N., Raffai, P., Rail, S. X., Raja, S., Rajan, C., Ramirez, K. E., Ramirez, T. D., Ramos-Buades, A., Rana, D., Rana, J., Rangnekar, P. R., Rapagnani, P., Ray, A., Raymond, V., Raza, N., Razzano, M., Read, J., Regimbau, T., Rei, L., Reid, S., Reid, S. W., Reinhard, M., Reitze, D. H., Relton, P., Renzini, A., Rettegno, P., Revenu, B., Reyes, J., Reza, A., Rezac, M., Rezaei, A. S., Ricci, F., Richards, D., Richardson, J. W., Richardson, L., Riles, K., Rinaldi, S., Robertson, C., Robertson, N. A., Robie, R., Robinet, F., Rocchi, A., Rodriguez, S., Rolland, L., Rollins, J. G., Romanelli, M., Romano, R., Romel, C. L., Romero, A., Romero-Shaw, I. M., Romie, J. H., Ronchini, S., Roocke, T. J., Rosa, L., Rose, C. A., Rosińska, D., Ross, M. P., Rossello, M., Rowan, S., Rowlinson, S. J., Roy, Santosh, Roy, Soumen, Royzman, A., Rozza, D., Ruggi, P., Morales, E. Ruiz, Ruiz-Rocha, K., Ryan, K., Sachdev, S., Sadecki, T., Sadiq, J., Saffarieh, P., Saha, S., Saito, Y., Sakai, K., Sakellariadou, M., Sakon, S., Salafia, O. S., Salces-Carcoba, F., Salconi, L., Saleem, M., Salemi, F., Sallé, M., Samajdar, A., Sanchez, E. J., Sanchez, J. H., Sanchez, L. E., Sanchis-Gual, N., Sanders, J. R., Sanuy, A., Saravanan, T. R., Sarin, N., Sasli, A., Sassolas, B., Satari, H., Sathyaprakash, B. S., Sauter, O., Savage, R. L., Savant, V., Sawada, T., Sawant, H. L., Sayah, S., Schaetzl, D., Scheel, M., Scheuer, J., Schiworski, M. G., Schmidt, P., Schmidt, S., Schnabel, R., Schneewind, M., Schofield, R. M. S., Schönbeck, A., Schulte, B. W., Schutz, B. F., Schwartz, E., Scott, J., Scott, S. M., Seglar-Arroyo, M., Sekiguchi, Y., Sellers, D., Sengupta, A. S., Sentenac, D., Seo, E. G., Sequino, V., Sergeev, A., Servignat, G., Setyawati, Y., Shaffer, T., Shahriar, M. S., Shaikh, M. A., Shams, B., Shao, L., Sharma, A., Sharma, P., Shawhan, P., Shcheblanov, N. S., Sheela, A., Sheridan, E., Shikano, Y., Shikauchi, M., Shimizu, H., Shimode, K., Shinkai, H., Shishido, T., Shoda, A., Shoemaker, D. H., Shoemaker, D. M., ShyamSundar, S., Sieniawska, M., Sigg, D., Silenzi, L., Singer, L. P., Singh, D., Singh, M. K., Singh, N., Singha, A., Sintes, A. M., Sipala, V., Skliris, V., Slagmolen, B. J. J., Slaven-Blair, T. J., Smetana, J., Smith, J. R., Smith, L., Smith, R. J. E., Soldateschi, J., Somala, S. N., Somiya, K., Song, I., Soni, K., Soni, S., Sordini, V., Sorrentino, F., Sorrentino, N., Soulard, R., Souradeep, T., Spagnuolo, V., Spencer, A. P., Spera, M., Spinicelli, P., Srivastava, A. K., Srivastava, V., Stachie, C., Stachurski, F., Steer, D. A., Steinlechner, J., Steinlechner, S., Stergioulas, N., Stevenson, S., Stops, D. J., Strain, K. A., Strang, L. C., Stratta, G., Strong, M. D., Strunk, A., Sturani, R., Stuver, A. L., Suchenek, M., Sudhagar, S., Sugimoto, R., Suh, H. G., Sullivan, A. G., Summerscales, T. Z., Sun, L., Sunil, S., Sur, A., Suresh, J., Sutton, P. J., Suzuki, Takamasa, Suzuki, Takanori, Suzuki, Toshikazu, Swinkels, B. L., Syx, A., Szczepańczyk, M. J., Szewczyk, P., Tacca, M., Tagoshi, H., Tait, S. C., Takahashi, H., Takahashi, R., Takano, S., Takeda, H., Takeda, M., Talbot, C. J., Talbot, C., Tamanini, N., Tanaka, K., Tanaka, Taiki, Tanaka, Takahiro, Tanasijczuk, A. J., Tanioka, S., Tanner, D. B., Tao, D., Tao, L., Tapia, R. D., Martín, E. N. Tapia San, Taranto, C., Taruya, A., Tasson, J. D., Tenorio, R., Terhune, J. E. S., Terkowski, L., Themann, H., Thirugnanasambandam, M. P., Thomas, M., Thomas, P., Thomas, S., Thompson, D., Thompson, E. E., Thompson, J. E., Thondapu, S. R., Thorne, K. A., Thrane, E., Tiwari, Shubhanshu, Tiwari, Srishti, Tiwari, V., Toivonen, A. M., Tolley, A. E., Tomaru, T., Tomura, T., Tonelli, M., Torres-Forné, A., Torrie, C. I., Melo, I. Tosta e, Tournefier, E., Töyrä, D., Trapananti, A., Travasso, F., Traylor, G., Trenado, J., Trevor, M., Tringali, M. C., Tripathee, A., Troiano, L., Trovato, A., Trozzo, L., Trudeau, R. J., Tsai, D., Tsang, K. W., Tsang, T., Tsao, J-S., Tse, M., Tso, R., Tsuchida, S., Tsukada, L., Tsuna, D., Tsutsui, T., Turbang, K., Turconi, M., Turski, C., Tuyenbayev, D., Ubach, H., Ubhi, A. S., Uchikata, N., Uchiyama, T., Udall, R. P., Ueda, A., Uehara, T., Ueno, K., Ueshima, G., Unnikrishnan, C. S., Urban, A. L., Ushiba, T., Utina, A., Vahlbruch, H., Vaidya, N., Vajente, G., Vajpeyi, A., Valdes, G., Valentini, M., Vallero, S., Valsan, V., van Bakel, N., van Beuzekom, M., van Dael, M., Brand, J. F. J. van den, Broeck, C. Van Den, Vander-Hyde, D. C., Van de Walle, A., van Dongen, J., van Haevermaet, H., van Heijningen, J. V., Vanosky, J., van Putten, M. H. P. M., van Ranst, Z., van Remortel, N., Vardaro, M., Vargas, A. F., Varma, V., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venneberg, J., Venugopalan, G., Verdier, P., Verkindt, D., Verma, P., Verma, Y., Vermeulen, S. M., Veske, D., Vetrano, F., Viceré, A., Vidyant, S., Viets, A. D., Vijaykumar, A., Villa-Ortega, V., Vinet, J. -Y., Virtuoso, A., Vitale, S., Vocca, H., von Reis, E. R. G., von Wrangel, J. S. A., Vorvick, C., Vyatchanin, S. P., Wade, L. E., Wade, M., Wagner, K. J., Walet, R. C., Walker, M., Wallace, G. S., Wallace, L., Wang, J., Wang, J. Z., Wang, W. H., Ward, R. L., Warner, J., Was, M., Washimi, T., Washington, N. Y., Watada, K., Watarai, D., Watchi, J., Wayt, K. E., Weaver, B., Weaving, C. R., Webster, S. A., Weinert, M., Weinstein, A. J., Weiss, R., Weller, C. M., Weller, R. A., Wellmann, F., Wen, L., Weßels, P., Wette, K., Whelan, J. T., White, D. D., Whiting, B. F., Whittle, C., Wilk, O. S., Wilken, D., Williams, C. E., Williams, D., Williams, M. J., Williamson, A. R., Willis, J. L., Willke, B., Wipf, C. C., Woan, G., Woehler, J., Wofford, J. K., Wojtowicz, I. A., Wong, D., Wong, I. C. F., Wright, M., Wu, C., Wu, D. S., Wu, H., Wysocki, D. M., Xiao, L., Yadav, N., Yamada, T., Yamamoto, H., Yamamoto, K., Yamamoto, T., Yamashita, K., Yamazaki, R., Yang, F. W., Yang, K. Z., Yang, L., Yang, Y. -C., Yang, Y., Yang, Yang, Yap, M. J., Yeeles, D. W., Yeh, S. -W., Yelikar, A. B., Yokoyama, J., Yokozawa, T., Yoo, J., Yoshioka, T., Yu, Hang, Yu, Haocun, Yuzurihara, H., Zadrożny, A., Zanolin, M., Zeidler, S., Zelenova, T., Zendri, J. -P., Zevin, M., Zhan, M., Zhang, H., Zhang, J., Zhang, L., Zhang, R., Zhang, T., Zhang, Y., Zhao, C., Zhao, G., Zhao, Y., Zhao, Yue, Zheng, Y., Zhou, R., Zhu, X. J., Zhu, Z. -H., Zimmerman, A. B., Zucker, M. E., Zweizig, J., Shandera, S., and Jeong, D.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We describe a search for gravitational waves from compact binaries with at least one component with mass 0.2 $M_\odot$ -- $1.0 M_\odot$ and mass ratio $q \geq 0.1$ in Advanced LIGO and Advanced Virgo data collected between 1 November 2019, 15:00 UTC and 27 March 2020, 17:00 UTC. No signals were detected. The most significant candidate has a false alarm rate of 0.2 $\mathrm{yr}^{-1}$. We estimate the sensitivity of our search over the entirety of Advanced LIGO's and Advanced Virgo's third observing run, and present the most stringent limits to date on the merger rate of binary black holes with at least one subsolar-mass component. We use the upper limits to constrain two fiducial scenarios that could produce subsolar-mass black holes: primordial black holes (PBH) and a model of dissipative dark matter. The PBH model uses recent prescriptions for the merger rate of PBH binaries that include a rate suppression factor to effectively account for PBH early binary disruptions. If the PBHs are monochromatically distributed, we can exclude a dark matter fraction in PBHs $f_\mathrm{PBH} \gtrsim 0.6$ (at 90% confidence) in the probed subsolar-mass range. However, if we allow for broad PBH mass distributions we are unable to rule out $f_\mathrm{PBH} = 1$. For the dissipative model, where the dark matter has chemistry that allows a small fraction to cool and collapse into black holes, we find an upper bound $f_{\mathrm{DBH}} < 10^{-5}$ on the fraction of atomic dark matter collapsed into black holes., Comment: https://dcc.ligo.org/P2200139

Published
2022
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213. Extraordinary diversity of the CD28/CTLA4 family across jawed vertebrates

Author

Sylvie M. A. Quiniou, Thomas Clark, Eva Bengtén, Jonathan P. Rast, Yuko Ohta, Martin Flajnik, and Pierre Boudinot

Subjects
CD28, CTLA4, PD1, CD28H, ICOS, Immune checkpoints, Immunologic diseases. Allergy, RC581-607
Abstract

Members of the CD28 family are critical for the control of immune cell activation. While CD28 and CTLA4 were previously identified in teleost fish, most members of the CD28 family have been described only in tetrapods. Using a comparative genomics approach, we found (co)orthologs of all members of the CD28 family both in Chondrichthyes and basal Osteichthyes groups, but not in Agnathans. Four additional members of the family were identified, which were present in both Chondrichthyes and Osteichthyes, some even in the tetrapod lineage but all of them absent in human. Herein, we extend the composition of the jawed vertebrate CD28 family to nine members: CD28, CTLA4, ICOS, CD28H, CD28HL1, CD28HL2, CD28HL3, CD28X and PD-1. Each of these genes had a single extracellular IgSF V domain, and conserved motifs in the V and the cytoplasmic domain. While a genomic cluster of three consecutive genes like CD28/CTLA4/ICOS was conserved across jawed vertebrates except in teleosts, the other members of the CD28 family were located on multiple chromosomes. Our findings show that these co-stimulatory/co-inhibitory receptors likely arose in early jawed vertebrates, and diversified when the Ig/TCR/MHC-based adaptive immunity emerged, heralding the advent of complex regulatory networks controlling lymphocyte activation.

Published
2024
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214. SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption

Author

Yoshihisa Mimura, Tomoya Yasujima, Katsuhisa Inoue, Shogo Akino, Chitaka Namba, Hiroyuki Kusuhara, Yutaro Sekiguchi, Kinya Ohta, Takahiro Yamashiro, and Hiroaki Yuasa

Subjects
SLC35G1, intestinal absorption, citrate, highly chloride-sensitive, basolateral membrane, Medicine, Science, Biology (General), QH301-705.5
Abstract

The intestinal absorption of essential nutrients, especially those not readily biosynthesized, is a critical physiological process for maintaining homeostasis. Numerous studies have indicated that intestinal absorption is mediated by various membrane transporters. Citrate, a crucial bioactive compound produced as an intermediate in the Krebs cycle, is absorbed in the small intestine through carrier-mediated systems because of its high hydrophilicity. While the luminal absorption of citrate is mediated by Na+-dicarboxylate cotransporter 1 (NaDC1/SLC13A2), the mechanism governing the release of the transported citrate into the bloodstream remains unknown. Here, we explored the transporters responsible for intestinal citrate absorption at the basolateral membrane, focusing on highly expressed orphan transporters in the small intestine as candidates. Consequently, SLC35G1, originally identified as a partner of stromal interaction molecule 1, a cell surface transmembrane glycoprotein, was found to play a role in the intestinal absorption of citrate at the basolateral membrane. Furthermore, our results revealed that SLC35G1-mediated citrate transport was diminished by chloride ions at physiologically relevant extracellular concentrations. This suggests that SLC35G1, to our best knowledge, is the first transporter identified to be extremely sensitive to chloride ions among those functioning on the basolateral membrane of intestinal epithelial cells. This study provides valuable insights into the intestinal absorption of citrate and significantly contributes to elucidating the poorly understood molecular basis of the intestinal absorption system.

Published
2024
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215. Protein profile of mouse endolymph suggests a role in controlling cochlear homeostasis

Author

Masatoshi Fukuda, Hiroki Okanishi, Daisuke Ino, Kazuya Ono, Takeru Ota, Eri Wakai, Takashi Sato, Yumi Ohta, Yoshiaki Kikkawa, Hidenori Inohara, Yoshikatsu Kanai, and Hiroshi Hibino

Subjects
Biochemical analysis, Molecular physiology, Proteomics, Science
Abstract

Summary: The cochlea contains two extracellular fluids, perilymph and endolymph. Endolymph exhibits high potential of approximately +80 to +110 mV (depending on species), which sensitizes sensory hair cells. Other properties of this unique fluid remain elusive, owing to its minuscule volume in rodent cochlea. We therefore developed a technique to collect high-purity endolymph from mouse cochleae. Comprehensive proteomic analysis of sampled endolymph using liquid chromatography with mass spectrometry identified 301 proteins, dominated by molecules engaged in immunity and proteostasis. Approximately 30% of these proteins were undetectable in our perilymph. A combination of mass spectrometry and different approaches revealed that, compared to perilymph, endolymph was enriched with α2-macroglobulin, osteopontin, apolipoprotein D, apolipoprotein E, and apolipoprotein J/clusterin. In other cells or tissues, α2-macroglobulin, apolipoprotein E, and apolipoprotein J contribute to the clearance of degraded proteins from extracellular fluid. Altogether, with the proteins described here, endolymph may play a protective role in stabilizing cochlear homeostasis.

Published
2024
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216. Nontuberculous mycobacterial pulmonary disease caused by Mycobacterium seoulense

Author

Keitaro Nakamoto, Keiji Fujiwara, Kozo Morimoto, and Ken Ohta

Subjects
Mycobacterium seoulense, nontuberculous mycobacteria, treatment, Diseases of the respiratory system, RC705-779
Abstract

Abstract Mycobacterium seoulense was first isolated and reported in Korea in 2007. We report a rare case of nontuberculous mycobacterial (NTM) pulmonary disease caused by M. seoulense. A woman in her mid‐90s was referred to our hospital due to bloody sputum. She had medical histories of chronic heart failure and chemoradiotherapy for right small cell lung carcinoma. Chest computed tomography showed a consolidation on the mediastinal side of the right lung following radiotherapy and nodules with bronchiectasis of the right upper and middle lobes. Acid‐fast culture tests of sputum were positive for M. seoulense. We are currently treating her with tranexamic acid and carbazochrome sodium sulfonate and conducting careful follow‐up. M. seoulense infection may need to be recognized as one of the notable NTM pulmonary diseases presenting with respiratory symptoms and radiological findings.

Published
2024
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217. Somatic mutation rates scale with time not growth rate in long-lived tropical trees

Author

Akiko Satake, Ryosuke Imai, Takeshi Fujino, Sou Tomimoto, Kayoko Ohta, Mohammad Na'iem, Sapto Indrioko, Widiyatno Widiyatno, Susilo Purnomo, Almudena Molla Morales, Viktoria Nizhynska, Naoki Tani, Yoshihisa Suyama, Eriko Sasaki, and Masahiro Kasahara

Subjects
somatic mutation, mutational spectrum, genetic diversity, tropical ecosystems, shorea, Medicine, Science, Biology (General), QH301-705.5
Abstract

The rates of appearance of new mutations play a central role in evolution. However, mutational processes in natural environments and their relationship with growth rates are largely unknown, particular in tropical ecosystems with high biodiversity. Here, we examined the somatic mutation landscapes of two tropical trees, Shorea laevis (slow-growing) and S. leprosula (fast-growing), in central Borneo, Indonesia. Using newly constructed genomes, we identified a greater number of somatic mutations in tropical trees than in temperate trees. In both species, we observed a linear increase in the number of somatic mutations with physical distance between branches. However, we found that the rate of somatic mutation accumulation per meter of growth was 3.7-fold higher in S. laevis than in S. leprosula. This difference in the somatic mutation rate was scaled with the slower growth rate of S. laevis compared to S. leprosula, resulting in a constant somatic mutation rate per year between the two species. We also found that somatic mutations are neutral within an individual, but those mutations transmitted to the next generation are subject to purifying selection. These findings suggest that somatic mutations accumulate with absolute time and older trees have a greater contribution towards generating genetic variation.

Published
2024
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218. Infraspinatus muscle necrosis in a cat with primary hyperaldosteronism

Author

Go Otani and Hiroshi Ohta

Subjects
Veterinary medicine, SF600-1100
Abstract

Case summary Persistent and progressive weakness secondary to hypokalaemia, that is, hypokalaemic polymyopathy, is one of the most common clinical signs of primary hyperaldosteronism (PHA). Herein, we report a case of PHA with infraspinatus muscle necrosis. A 5-year-old castrated male domestic shorthair cat presented with a history of polyuria and polydipsia, decreased activity, staggering gait, difficulty in jumping and inward rotation of both forelimbs. Blood examination revealed hypokalaemia, increased serum creatinine kinase activity and high serum aldosterone concentration. Abdominal ultrasonography and CT revealed an enlarged right adrenal gland. Post-contrast thoracic CT showed peripheral contrast enhancement and a non-enhanced centre in the bilateral infraspinatus muscles. From the day of initial presentation, the cat was started on oral potassium replacement therapy. On day 17, the right adrenal gland was surgically resected and the left infraspinatus muscle was biopsied. Histopathological examination confirmed the presence of an adrenocortical adenoma in the right adrenal gland and necrosis of the muscle fibres in the left infraspinatus muscle. On day 29, all clinical signs had disappeared, and the serum potassium concentration, creatinine kinase activity and aldosterone concentration had normalised. On day 57, atrophy of the bilateral infraspinatus muscles was noted, but there was no evidence of any posture or gait abnormalities. Relevance and novel information To the authors’ knowledge, this is the first report of possible infraspinatus muscle necrosis in a cat with PHA. It is also possible that the infrinatus muscle necrosis with hypokalaemic polymyopathy secondary to PHA was caused by compartment syndrome in the cat described here.

Published
2024
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219. miR‐4448/Girdin/Akt/AMPK axis inhibits EZH2‐mediated EMT and tumorigenesis in small‐cell lung cancer

Author

Nobuyuki Koyama, Yuichi Ishikawa, Hiromitsu Ohta, Takuya Aoki, Hiroyuki Kyoyama, Kazutetsu Aoshiba, and Kazutsugu Uematsu

Subjects
Akt, AMP‐activated protein kinase, epithelial‐mesenchymal transition, enhancer of zeste homolog 2, Girdin, miR‐4448, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Small‐cell lung cancer (SCLC) shows high enhancer of zeste homolog 2 (EZH2) expressions. EZH2‐mediated epigenetics promote epithelial‐mesenchymal transition (EMT), enhancing invasive and metastatic potential in malignancies. MicroRNAs (miRNAs), small noncoding RNAs, modulate EMT, determining tumor phenotypes. However, the association between miRNAs and EZH2 in SCLC remains to be clarified—we aimed to identify a novel tumorigenic mechanism through miRNAs, EZH2, and EMT in SCLC, leading to future therapeutic applications. Methods We analyzed EZH2 and E‐cadherin expressions in lung cancer cell lines and tumor tissues from 34 SCLC patients and confirmed EZH2 siRNA‐mediated EMT inhibition. miRNA expression profiles were compared between EZH2 knockdown SCLC cells and negative control SCLC cells using miRNA array. We identified a target miRNA of EZH2 showing expressional differences in EZH2‐knockdown cells and analyzed the impact of the miRNA on EZH2‐mediated EMT and tumorigenesis. Results All SCLC cells showed increased EZH2 and decreased E‐cadherin expressions. SCLC tissues had higher EZH2 and lower E‐cadherin expressions than other lung cancer tissues. miRNA array revealed that miR‐4448 expression increased in EZH2‐knockdown SCLC cells. miR‐4448 overexpression reduced tumor cell growth and prevented EMT. miR‐4448 bound to the 3′UTR of the girdin gene and suppressed its expression, thereby decreasing Akt phosphorylation at Ser473. Attenuated Akt phosphorylation resulted in AMP‐activated protein kinase (AMPK) phosphorylation at Thr172 and 183, enhancing EZH2 phosphorylation at Thr311. Conclusion SCLC characterized high EZH2 expression and promoted EMT, compared with non‐small cell lung cancer. miR‐4448 inhibited Girdin expression, reducing Akt phosphorylation, and enhancing AMPK and EZH2 phosphorylation. Eventually, miR‐4448 prevented EZH2‐mediated EMT and tumorigenesis by modulating the Girdin/Akt/AMPK axis in SCLC. miR‐4448 might be a potential SCLC inhibitor.

Published
2024
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221. Rational quinidine dosage regimen for atrial fibrillation in Thoroughbred racehorses based on population pharmacokinetics

Author

Taisuke Kuroda, Yohei Minamijima, Christopher Ken Kinman, Yuji Takahashi, Yusaku Ebisuda, Kaori Inoue, Hiroshi Ishikawa, Hiroshi Mita, Norihisa Tamura, Toshio Nukada, Pierre-Louis Toutain, and Minoru Ohta

Subjects
quinidine, atrial fibrillation, horse, population pharmacokinetics, dosage regimen, Veterinary medicine, SF600-1100
Abstract

IntroductionQuinidine (QND) sulfate is an effective treatment for atrial fibrillation (AF) in horses, and several dosage regimens have been proposed to address its wide variability in response and potential adverse effects. The purpose of this study was to analyze the variability in plasma quinidine concentrations using population pharmacokinetics to determine an effective and safe dosage regimen for Thoroughbred horses.MethodsSix healthy Thoroughbred horses were treated with 20 mg/kg quinidine sulfate dihydrate (16.58 mg/kg QND base) administered PO or 5 mg/kg quinidine hydrochloride monohydrate (4.28 mg/kg QND base) administered IV (single administration), and blood samples were taken regularly. Four healthy horses were treated with 20 mg/kg quinidine sulfate dihydrate administered twice (every 6 h) via PO route. For the other 19 Thoroughbred racehorses that developed AF, blood samples were taken during quinidine therapy. Quinidine concentrations were measured in all plasma samples using liquid chromatography with tandem mass spectrometry, and the data from 29 horses were modeled using a nonlinear mixed-effects model, followed by Monte Carlo simulations (MCS).ResultsThe median quinidine concentration for successful sinus rhythm conversion was 2.0 μg/mL (range: 0.5–2.7 μg/mL) in AF horses, while a median concentration of 3.8 μg/mL (range: 1.6–5.1 μg/mL) showed adverse effects. MCS predicted that plasma quinidine concentrations for quinidine sulfate dihydrate PO administration (loading dose: 30 mg/kg, maintenance dose: 6.5 mg/kg q 2 h) reached 1.4, 2.0 and 2.7 μg/mL in 90, 50 and 10% of the horse populations, respectively. Increasing the loading dose to 45 mg/kg and the maintenance dose to 9 mg/kg q 2 h, the plasma concentrations achieved were 1.9, 2.8, and 3.8 μg/mL in 90, 50, and 10% of horse populations, respectively.DiscussionUsing simulations, different empirical dosing regimens were proposed to achieve plasma quinidine concentrations immediately or progressively, representing a tradeoff between optimizing therapeutic effects and minimizing adverse effects. A combination of these dosing regimens is recommended to gradually increase the therapeutic concentration levels of quinidine for safe and effective treatment of AF in racehorses.

Published
2024
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222. Small-angle X-ray scattering analysis of poly(amic acid) dispersed in a liquid matrix to understand the size control of polyimide nanoparticles

Author

Satoshi Kuretani, Kazushige Hori, Tomoyasu Hirai, Noboru Ohta, Kan Hatakeyama-Sato, Teruaki Hayakawa, and Yuta Nabae

Subjects
polyimide, poly(amic acid), nanoparticle, precipitation, dispersant, SASX, Science
Abstract

Poly(amic ‍acid) ‍nanoparticles ‍prepared ‍by ‍‍precipitation ‍polymerization with a dispersant were evaluated by small-angle X-ray scattering (SAXS) and field-emission scanning electron microscopy (FE-SEM). The particle size evaluation of poly(amic acid) nanoparticles in the liquid phase by SAXS was performed to gain insight into the size control of poly(amic acid) nanoparticles, and showed good agreement with visual observation by FE-SEM, explaining the effect of the dispersant in obtaining polyimide nanoparticles with small particle size. This indicates that the particle size is maintained without change during the solvent evaporation process. The polyamide nanoparticles controlled by the dispersant effect maintained their size after imidization, and polyimide nanoparticles with a minimum radius of about 60 nm were prepared.

Published
2024
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223. Concurrent validity, cut‐offs and ability to change of patient‐reported outcome measures for rhinitis and asthma in MASK‐air®

Author

Jean Bousquet, Bernardo Sousa‐Pinto, Josep M. Anto, Anna Bedbrook, Wienczyslawa Czarlewski, Ignacio J. Ansotegui, Karl‐C. Bergmann, Fulvio Braido, Luisa Brussino, Lorenzo Cecchi, Claudia Chaves Loureiro, Alvaro A. Cruz, Philippe Devillier, Alessandro Fiocchi, Bilun Gemicioglu, Tari Haahtela, Juan Carlos Ivancevich, Ludger Klimek, Marek Kulus, Piotr Kuna, Maciej Kupczyk, Violeta Kvedariene, Desiree E. Larenas‐Linnemann, Gilles Louis, Renaud Louis, Michael Makris, Mario Morais‐Almeida, Marek Niedoszytko, Ken Ohta, Markus Ollert, Nikolaos Papadopoulos, Vincenzo Patella, Benoit Pétré, Oliver Pfaar, Francesca Puggioni, Santiago Quirce, Frederico S. Regateiro, Nicolas Roche, Philip W. Rouadi, Boleslaw Samolinski, Joaquin Sastre, Florence Schleich, Nicola Scichilone, Luis Taborda‐Barata, Sanna Toppila‐Salmi, Arunas Valiulis, Ilgim Vardaloglu Koyuncu, Maria Teresa Ventura, Arzu Yorgancioglu, Joao A. Fonseca, and Torsten Zuberbier

Subjects
asthma, digital health, EQ‐5D, rhinitis, visual analogue scale, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Patient‐reported outcome measures (PROMs) are used to assess a patient's health status at a particular point in time. They are essential in the development of person‐centred care. This paper reviews studies performed on PROMs for assessing AR and asthma control, in particular VAS scales that are included in the app MASK‐air® (Mobile Airways Sentinel networK) for asthma and rhinitis. VASs were initially developed on paper and pencil and tested for their criterion validity, cut‐offs and responsiveness. Then, a multicentric, multinational, double‐blind, placebo‐controlled, randomised control trial (DB‐PC‐RCT) using an electronic VAS form was carried out. Finally, with the development of MASK‐air® in 2015, previously validated VAS questions were adapted to the digital format and further methodologic evaluations were performed. VAS for asthma, rhinitis, conjunctivitis, work and EQ‐5D are included in the app. Additionally, two control‐medication scores for allergic symptoms of asthma (e‐DASTHMA) were validated for their criterion validity, cut‐offs and responsiveness.

Published
2024
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224. Forced oscillation control with a wearable reaction wheel to assist human periodic arm swing

Author

Takuya Otani, Takahisa Kondo, Akira Itoh, Soma Sugiyama, Hina Ohta, and Atsuo Takanishi

Subjects
Electronics, TK7800-8360, Electronic computers. Computer science, QA75.5-76.95
Abstract

Rehabilitation for stroke patients includes periodic arm exercises, but these require assistance by caregivers at the start of the exercise, which is a burden for caregivers. In this study, we have developed a system with three reaction wheel mechanisms, which can generate not only moments in each direction but also a larger moment than the output of a single axis by interlocking the axes. In addition, by using forced oscillation control, it is possible to assist the movement of the wearer's periodic arm swing even if the weight and output moment of the reaction wheel is not large. Although a large torque of 2.65 Nm is required for the system to swing the arm, it was confirmed that the developed device can be used to increase the amplitude of arm oscillation and achieve an oscillation frequency equivalent to that of a human arm swing, even with a single reaction wheel exerting a torque of 0.4 Nm.

Published
2024
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225. Molecular mechanisms of avian immunoglobulin gene diversification and prospect for industrial applications

Author

Hidetaka Seo, Kouji Hirota, and Kunihiro Ohta

Subjects
gene conversion, somatic hypermutation, homologous recombination, DNA damage tolerance, monoclonal antibody, therapeutic antibody, Immunologic diseases. Allergy, RC581-607
Abstract

Poultry immunoglobulin genes undergo diversification through homologous recombination (HR) and somatic hypermutation (SHM). Most animals share a similar system in immunoglobulin diversification, with the rare exception that human and murine immunoglobulin genes diversify through V(D)J recombination. Poultry possesses only one functional variable gene for each immunoglobulin heavy (HC) and light chains (LC), with clusters of non-productive pseudogenes upstream. During the B cell development, the functional variable gene is overwritten by sequences from the pseudo-variable genes via a process known as gene conversion (GC), a kind of HR. Point mutations caused in the functional variable gene also contribute to immunoglobulin diversification. This review discusses the latest findings on the molecular mechanisms of antibody gene diversification in poultry, using chickens as a model. Additionally, it will outline how these basic research findings have recently been applied especially in the medical field.

Published
2024
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226. Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues

Author

Charoensawan, Varodom, Hon, Chung-Chau, Majumder, Partha P., Matangkasombut, Ponpan, Park, Woong-Yang, Prabhakar, Shyam, Shin, Jay W., Carninci, Piero, Chambers, John C., Loh, Marie, Pithukpakorn, Manop, Suktitipat, Bhoom, Yamamoto, Kazuhiko, Rajagopalan, Deepa, Rayan, Nirmala Arul, Sankaran, Shvetha, Chantaraamporn, Juthamard, Chatterjee, Ankita, Ghosh, Supratim, Han, Kyung Yeon, Jevapatarakul, Damita, Nguantad, Sarintip, Sarkar, Sumanta, Thungsatianpun, Narita, Abe, Mai, Furukawa, Seiko, Inoue, Gyo, Myouzen, Keiko, Oh, Jin-Mi, Suzuki, Akari, Ando, Yoshinari, Kojima, Miki, Kouno, Tsukasa, Lim, Jinyeong, Maitra, Arindam, Tan, Le Min, Venkatesh, Prasanna Nori, Choi, Murim, Park, Jong-Eun, Buyamin, Eliora Violain, Kock, Kian Hong, Xuan Lin, Quy Xiao, Moody, Jonathan, Sonthalia, Radhika, Ishigaki, Kazuyoshi, Nakano, Masahiro, Okada, Yukinori, Tomofuji, Yoshihiko, Ho Namkoong, Edahiro, Ryuya, Takano, Tomomi, Nishihara, Hiroshi, Shirai, Yuya, Sonehara, Kyuto, Tanaka, Hiromu, Azekawa, Shuhei, Mikami, Yohei, Lee, Ho, Hasegawa, Takanori, Okudela, Koji, Okuzaki, Daisuke, Motooka, Daisuke, Kanai, Masahiro, Naito, Tatsuhiko, Yamamoto, Kenichi, Wang, Qingbo S., Saiki, Ryunosuke, Ishihara, Rino, Matsubara, Yuta, Hamamoto, Junko, Hayashi, Hiroyuki, Yoshimura, Yukihiro, Tachikawa, Natsuo, Yanagita, Emmy, Hyugaji, Takayoshi, Shimizu, Eigo, Katayama, Kotoe, Kato, Yasuhiro, Morita, Takayoshi, Takahashi, Kazuhisa, Harada, Norihiro, Naito, Toshio, Hiki, Makoto, Matsushita, Yasushi, Takagi, Haruhi, Aoki, Ryousuke, Nakamura, Ai, Harada, Sonoko, Sasano, Hitoshi, Kabata, Hiroki, Masaki, Katsunori, Kamata, Hirofumi, Ikemura, Shinnosuke, Chubachi, Shotaro, Okamori, Satoshi, Terai, Hideki, Morita, Atsuho, Asakura, Takanori, Sasaki, Junichi, Morisaki, Hiroshi, Uwamino, Yoshifumi, Nanki, Kosaku, Uchida, Sho, Uno, Shunsuke, Nishimura, Tomoyasu, Ishiguro, Takashi, Isono, Taisuke, Shibata, Shun, Matsui, Yuma, Hosoda, Chiaki, Takano, Kenji, Nishida, Takashi, Kobayashi, Yoichi, Takaku, Yotaro, Takayanagi, Noboru, Ueda, Soichiro, Tada, Ai, Miyawaki, Masayoshi, Yamamoto, Masaomi, Yoshida, Eriko, Hayashi, Reina, Nagasaka, Tomoki, Arai, Sawako, Kaneko, Yutaro, Sasaki, Kana, Tagaya, Etsuko, Kawana, Masatoshi, Arimura, Ken, Takahashi, Kunihiko, Anzai, Tatsuhiko, Ito, Satoshi, Endo, Akifumi, Uchimura, Yuji, Miyazaki, Yasunari, Honda, Takayuki, Tateishi, Tomoya, Tohda, Shuji, Ichimura, Naoya, Sonobe, Kazunari, Sassa, Chihiro Tani, Nakajima, Jun, Nakano, Yasushi, Nakajima, Yukiko, Anan, Ryusuke, Arai, Ryosuke, Kurihara, Yuko, Harada, Yuko, Nishio, Kazumi, Ueda, Tetsuya, Azuma, Masanori, Saito, Ryuichi, Sado, Toshikatsu, Miyazaki, Yoshimune, Sato, Ryuichi, Haruta, Yuki, Nagasaki, Tadao, Yasui, Yoshinori, Hasegawa, Yoshinori, Mutoh, Yoshikazu, Kimura, Tomoki, Sato, Tomonori, Takei, Reoto, Hagimoto, Satoshi, Noguchi, Yoichiro, Yamano, Yasuhiko, Sasano, Hajime, Ota, Sho, Nakamori, Yasushi, Yoshiya, Kazuhisa, Saito, Fukuki, Yoshihara, Tomoyuki, Wada, Daiki, Iwamura, Hiromu, Kanayama, Syuji, Maruyama, Shuhei, Yoshiyama, Takashi, Ohta, Ken, Kokuto, Hiroyuki, Ogata, Hideo, Tanaka, Yoshiaki, Arakawa, Kenichi, Shimoda, Masafumi, Osawa, Takeshi, Tateno, Hiroki, Hase, Isano, Yoshida, Shuichi, Suzuki, Shoji, Kawada, Miki, Horinouchi, Hirohisa, Saito, Fumitake, Mitamura, Keiko, Hagihara, Masao, Ochi, Junichi, Uchida, Tomoyuki, Baba, Rie, Arai, Daisuke, Ogura, Takayuki, Takahashi, Hidenori, Hagiwara, Shigehiro, Nagao, Genta, Konishi, Shunichiro, Nakachi, Ichiro, Murakami, Koji, Yamada, Mitsuhiro, Sugiura, Hisatoshi, Sano, Hirohito, Matsumoto, Shuichiro, Kimura, Nozomu, Ono, Yoshinao, Baba, Hiroaki, Suzuki, Yusuke, Nakayama, Sohei, Masuzawa, Keita, Namba, Shinichi, Suzuki, Ken, Naito, Yoko, Liu, Yu-Chen, Takuwa, Ayako, Sugihara, Fuminori, Wing, James B., Sakakibara, Shuhei, Hizawa, Nobuyuki, Shiroyama, Takayuki, Miyawaki, Satoru, Kawamura, Yusuke, Nakayama, Akiyoshi, Matsuo, Hirotaka, Yuichi, Maeda, Nii, Takuro, Noda, Yoshimi, Niitsu, Takayuki, Adachi, Yuichi, Enomoto, Takatoshi, Amiya, Saori, Hara, Reina, Yamaguchi, Yuta, Murakami, Teruaki, Kuge, Tomoki, Matsumoto, Kinnosuke, Yamamoto, Yuji, Yamamoto, Makoto, Yoneda, Midori, Kishikawa, Toshihiro, Yamada, Shuhei, Kawabata, Shuhei, Kijima, Noriyuki, Takagaki, Masatoshi, Sasa, Noah, Ueno, Yuya, Suzuki, Motoyuki, Takemoto, Norihiko, Eguchi, Hirotaka, Fukusumi, Takahito, Imai, Takao, Fukushima, Munehisa, Kishima, Haruhiko, Inohara, Hidenori, Tomono, Kazunori, Kato, Kazuto, Takahashi, Meiko, Matsuda, Fumihiko, Hirata, Haruhiko, Takeda, Yoshito, Koh, Hidefumi, Manabe, Tadashi, Funatsu, Yohei, Ito, Fumimaro, Fukui, Takahiro, Shinozuka, Keisuke, Kohashi, Sumiko, Miyazaki, Masatoshi, Shoko, Tomohisa, Kojima, Mitsuaki, Adachi, Tomohiro, Ishikawa, Motonao, Takahashi, Kenichiro, Inoue, Takashi, Hirano, Toshiyuki, Kobayashi, Keigo, Takaoka, Hatsuyo, Watanabe, Kazuyoshi, Miyazawa, Naoki, Kimura, Yasuhiro, Sado, Reiko, Sugimoto, Hideyasu, Kamiya, Akane, Kuwahara, Naota, Fujiwara, Akiko, Matsunaga, Tomohiro, Sato, Yoko, Okada, Takenori, Hirai, Yoshihiro, Kawashima, Hidetoshi, Narita, Atsuya, Niwa, Kazuki, Sekikawa, Yoshiyuki, Nishi, Koichi, Nishitsuji, Masaru, Tani, Mayuko, Suzuki, Junya, Nakatsumi, Hiroki, Ogura, Takashi, Kitamura, Hideya, Hagiwara, Eri, Murohashi, Kota, Okabayashi, Hiroko, Mochimaru, Takao, Nukaga, Shigenari, Satomi, Ryosuke, Oyamada, Yoshitaka, Mori, Nobuaki, Baba, Tomoya, Fukui, Yasutaka, Odate, Mitsuru, Mashimo, Shuko, Makino, Yasushi, Yagi, Kazuma, Hashiguchi, Mizuha, Kagyo, Junko, Shiomi, Tetsuya, Fuke, Satoshi, Saito, Hiroshi, Tsuchida, Tomoya, Fujitani, Shigeki, Takita, Mumon, Morikawa, Daiki, Yoshida, Toru, Izumo, Takehiro, Inomata, Minoru, Kuse, Naoyuki, Awano, Nobuyasu, Tone, Mari, Ito, Akihiro, Nakamura, Yoshihiko, Hoshino, Kota, Maruyama, Junichi, Ishikura, Hiroyasu, Takata, Tohru, Odani, Toshio, Amishima, Masaru, Hattori, Takeshi, Shichinohe, Yasuo, Kagaya, Takashi, Kita, Toshiyuki, Ohta, Kazuhide, Sakagami, Satoru, Koshida, Kiyoshi, Hayashi, Kentaro, Shimizu, Tetsuo, Kozu, Yutaka, Hiranuma, Hisato, Gon, Yasuhiro, Izumi, Namiki, Nagata, Kaoru, Ueda, Ken, Taki, Reiko, Hanada, Satoko, Kawamura, Kodai, Ichikado, Kazuya, Nishiyama, Kenta, Muranaka, Hiroyuki, Nakamura, Kazunori, Hashimoto, Naozumi, Wakahara, Keiko, Koji, Sakamoto, Omote, Norihito, Ando, Akira, Kodama, Nobuhiro, Kaneyama, Yasunari, Shunsuke, Maeda, Kuraki, Takashige, Matsumoto, Takemasa, Yokote, Koutaro, Nakada, Taka-Aki, Abe, Ryuzo, Oshima, Taku, Shimada, Tadanaga, Harada, Masahiro, Takahashi, Takeshi, Ono, Hiroshi, Sakurai, Toshihiro, Shibusawa, Takayuki, Kimizuka, Yoshifumi, Kawana, Akihiko, Sano, Tomoya, Watanabe, Chie, Suematsu, Ryohei, Sageshima, Hisako, Yoshifuji, Ayumi, Ito, Kazuto, Takahashi, Saeko, Ishioka, Kota, Nakamura, Morio, Masuda, Makoto, Wakabayashi, Aya, Watanabe, Hiroki, Ueda, Suguru, Nishikawa, Masanori, Chihara, Yusuke, Takeuchi, Mayumi, Onoi, Keisuke, Shinozuka, Jun, Sueyoshi, Atsushi, Nagasaki, Yoji, Okamoto, Masaki, Ishihara, Sayoko, Shimo, Masatoshi, Tokunaga, Yoshihisa, Kusaka, Yu, Ohba, Takehiko, Isogai, Susumu, Ogawa, Aki, Inoue, Takuya, Fukuyama, Satoru, Eriguchi, Yoshihiro, Yonekawa, Akiko, Kan-o, Keiko, Matsumoto, Koichiro, Kanaoka, Kensuke, Ihara, Shoichi, Komuta, Kiyoshi, Inoue, Yoshiaki, Chiba, Shigeru, Yamagata, Kunihiro, Hiramatsu, Yuji, Kai, Hirayasu, Asano, Koichiro, Oguma, Tsuyoshi, Ito, Yoko, Hashimoto, Satoru, Yamasaki, Masaki, Kasamatsu, Yu, Komase, Yuko, Hida, Naoya, Tsuburai, Takahiro, Oyama, Baku, Takada, Minoru, Kanda, Hidenori, Kitagawa, Yuichiro, Fukuta, Tetsuya, Miyake, Takahito, Yoshida, Shozo, Ogura, Shinji, Abe, Shinji, Kono, Yuta, Togashi, Yuki, Takoi, Hiroyuki, Kikuchi, Ryota, Ogawa, Shinichi, Ogata, Tomouki, Ishihara, Shoichiro, Kanehiro, Arihiko, Ozaki, Shinji, Fuchimoto, Yasuko, Wada, Sae, Fujimoto, Nobukazu, Nishiyama, Kei, Terashima, Mariko, Beppu, Satoru, Yoshida, Kosuke, Narumoto, Osamu, Nagai, Hideaki, Ooshima, Nobuharu, Motegi, Mitsuru, Umeda, Akira, Miyagawa, Kazuya, Shimada, Hisato, Endo, Mayu, Ohira, Yoshiyuki, Watanabe, Masafumi, Inoue, Sumito, Igarashi, Akira, Sato, Masamichi, Sagara, Hironori, Tanaka, Akihiko, Ohta, Shin, Kimura, Tomoyuki, Shibata, Yoko, Tanino, Yoshinori, Nikaido, Takefumi, Minemura, Hiroyuki, Sato, Yuki, Yamada, Yuichiro, Hashino, Takuya, Shinoki, Masato, Iwagoe, Hajime, Takahashi, Hiroshi, Fujii, Kazuhiko, Kishi, Hiroto, Kanai, Masayuki, Imamura, Tomonori, Yamashita, Tatsuya, Yatomi, Masakiyo, Maeno, Toshitaka, Hayashi, Shinichi, Takahashi, Mai, Kuramochi, Mizuki, Kamimaki, Isamu, Tominaga, Yoshiteru, Ishii, Tomoo, Utsugi, Mitsuyoshi, Ono, Akihiro, Tanaka, Toru, Kashiwada, Takeru, Fujita, Kazue, Saito, Yoshinobu, Seike, Masahiro, Watanabe, Hiroko, Matsuse, Hiroto, Kodaka, Norio, Nakano, Chihiro, Oshio, Takeshi, Hirouchi, Takatomo, Makino, Shohei, Egi, Moritoki, Omae, Yosuke, Nannya, Yasuhito, Ueno, Takafumi, Katayama, Kazuhiko, Ai, Masumi, Fukui, Yoshinori, Kumanogoh, Atsushi, Sato, Toshiro, Hasegawa, Naoki, Tokunaga, Katsushi, Ishii, Makoto, Koike, Ryuji, Kitagawa, Yuko, Kimura, Akinori, Imoto, Seiya, Miyano, Satoru, Ogawa, Seishi, Kanai, Takanori, Fukunaga, Koichi, Takeshima, Yusuke, Tanaka, Kentaro, Koichi Matsuda, Yamanashi, Yuji, Furukawa, Yoichi, Morisaki, Takayuki, Murakami, Yoshinori, Kamatani, Yoichiro, Muto, Kaori, Nagai, Akiko, Nakamura, Yusuke, Obara, Wataru, Yamaji, Ken, Asai, Satoshi, Takahashi, Yasuo, Higashiue, Shinichi, Kobayashi, Shuzo, Yamaguchi, Hiroki, Nagata, Yasunobu, Wakita, Satoshi, Nito, Chikako, Iwasaki, Yu-ki, Murayama, Shigeo, Yoshimori, Kozo, Miki, Yoshio, Obata, Daisuke, Higashiyama, Masahiko, Masumoto, Akihide, Koga, Yoshinobu, Koretsune, Yukihiro, Yata, Tomohiro, Ogawa, Kotaro, Namkoong, Ho, Okuno, Tatsusada, Liu, Boxiang, Matsuda, Koichi, and Mochizuki, Hideki

Published
2024
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236. Exploring Tissues-Bias DNA Methylation of Two Sex-Related Genes (Cyp19a1 and Dmrt1) in Correlation with Gene Expression in Japanese Anchovy (Engraulis Japonicus)

Author

Dam, Anh Tuan, Galotta, Mariel, Eto, Yuhei, Mohapatra, Sipra, Matsuyama, Michiya, Chakraborty, Tapas, Ohta, Kohei, Wakayama, Masato, Editor-in-Chief, Anderssen, Robert S., Series Editor, Baryshnikov, Yuliy, Series Editor, Bauschke, Heinz H., Series Editor, Broadbridge, Philip, Series Editor, Cheng, Jin, Series Editor, Chyba, Monique, Series Editor, Cottet, Georges-Henri, Series Editor, Cuminato, José Alberto, Series Editor, Ei, Shin-ichiro, Series Editor, Fukumoto, Yasuhide, Series Editor, Hosking, Jonathan R. M., Series Editor, Jofré, Alejandro, Series Editor, Kimura, Masato, Series Editor, Landman, Kerry, Series Editor, McKibbin, Robert, Series Editor, Parmeggiani, Andrea, Series Editor, Pipher, Jill, Series Editor, Polthier, Konrad, Series Editor, Saeki, Osamu, Series Editor, Schilders, Wil, Series Editor, Shen, Zuowei, Series Editor, Toh, Kim Chuan, Series Editor, Verbitskiy, Evgeny, Series Editor, Yoshida, Nakahiro, Series Editor, Ta, Ton Viet, editor, and Nguyen, Linh Thi Hoai, editor

Published
2024
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237. Cold Tolerance in the Nematode Caenorhabditis elegans

Author

Kuhara, Atsushi, Takagaki, Natsune, Okahata, Misaki, Ohta, Akane, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Rosenhouse-Dantsker, Avia, Editorial Board Member, Tominaga, Makoto, editor, and Takagi, Masahiro, editor

Published
2024
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239. Automatic Extraction of User-Centric Aspects for Tourist Spot Recommender Systems Using Reviews in Japanese

Author

Uwano, Fumito, Kobayashi, Ran’u, Ohta, Manabu, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, van Leeuwen, Jan, Series Editor, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Kobsa, Alfred, Series Editor, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Nierstrasz, Oscar, Series Editor, Pandu Rangan, C., Editorial Board Member, Sudan, Madhu, Series Editor, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Deshpande, R.D., Series Editor, Vardi, Moshe Y, Series Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Mori, Hirohiko, editor, and Asahi, Yumi, editor

Published
2024
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242. HyperPIE: Hyperparameter Information Extraction from Scientific Publications

Author

Saier, Tarek, Ohta, Mayumi, Asakura, Takuto, Färber, Michael, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Goharian, Nazli, editor, Tonellotto, Nicola, editor, He, Yulan, editor, Lipani, Aldo, editor, McDonald, Graham, editor, Macdonald, Craig, editor, and Ounis, Iadh, editor

Published
2024
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243. The Emergence, Development, and Future Mission of Hydrogen Medicine and Biology

Author

Ohta, Shigeo, Dhalla, Naranjan S., Series Editor, Bolli, Roberto, Editorial Board Member, Goyal, Ramesh, Editorial Board Member, Kartha, Chandrasekharan, Editorial Board Member, Kirshenbaum, Lorrie, Editorial Board Member, Makino, Naoki, Editorial Board Member, Mehta, Jawahar L. L., Editorial Board Member, Ostadal, Bohuslav, Editorial Board Member, Pierce, Grant N., Editorial Board Member, Slezak, Jan, Editorial Board Member, Varro, Andras, Editorial Board Member, Werdan, Karl, Editorial Board Member, Weglicki, William B., Editorial Board Member, and Kura, Branislav, editor

Published
2024
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245. The International Linear Collider: Report to Snowmass 2021

Author

Aryshev, Alexander, Behnke, Ties, Berggren, Mikael, Brau, James, Craig, Nathaniel, Freitas, Ayres, Gaede, Frank, Gessner, Spencer, Gori, Stefania, Grojean, Christophe, Heinemeyer, Sven, Jeans, Daniel, Kruger, Katja, List, Benno, List, Jenny, Liu, Zhen, Michizono, Shinichiro, Miller, David W., Moult, Ian, Murayama, Hitoshi, Nakada, Tatsuya, Nanni, Emilio, Nojiri, Mihoko, Padamsee, Hasan, Perelstein, Maxim, Peskin, Michael E., Poeschl, Roman, Posen, Sam, Robson, Aidan, Strube, Jan, Suehara, Taikan, Tian, Junping, Titov, Maxim, Vos, Marcel, White, Andrew, Wilson, Graham, Yokoya, Kaoru, Zarnecki, Aleksander Filip, Adachi, Ichiro, Agashe, Kaustubh, Jovin, Tatjana Agatonovic, Aihara, Hiroaki, Altmannshofer, Wolfgang, Alves, Daniele, Anguiano, Justin, Aoki, Ken-Ichi, Aoki, Masato, Aoki, Toshihiro, Aoki, Yumi, Arai, Yasuo, Araki, Hayato, Asada, Haruka, Asai, Kento, Asai, Shoji, Attie, David, Baer, Howard, Bagger, Jonathan, Bai, Yang, Bailey, Ian, Barrue, Ricardo, Bartoldus, Rainer, Barzi, Emanuela, Basso, Matthew, Bauerdick, Lothar, Baum, Sebastian, Bellerive, Alain, Belomestnykh, Sergey, Antequera, Jorge Berenguer, Beyer, Jakob, Bhat, Pushpalatha, Bilki, Burak, Black, Kevin, Bloom, Kenneth, Bodwin, Geoffrey, Boisvert, Veronique, Boran, Fatma, Boudry, Vincent, Boughezal, Radja, Boveia, Antonio, Bozovic-Jelisavcic, Ivanka, Brient, Jean-Claude, Brodsky, Stanley, Brunetti, Laurent, Buesser, Karsten, Bulyak, Eugene, Burrows, Philip N., Burt, Graeme C., Cai, Yunhai, Cairo, Valentina, Canepa, Anadi, Celiberto, Francesco Giovanni, Cenni, Enrico, Chacko, Zackaria, Chaikovska, Iryna, Checchin, Mattia, Chen, Lisong, Chen, Thomas Y., Cheng, Hsin Chia, Cho, Gi-Chol, Choudhary, Brajesh, Clarke, Jim, Cline, James, Co, Raymond, Cohen, Timothy, Colas, Paul, Damerell, Chris, Das, Arindam, Dasu, Sridhara, Dawson, Sally, de Blas, Jorge, de Lima, Carlos Henrique, Deandrea, Aldo, Dehmelt, Klaus, Delayen, Jean, Demarteau, Marcel, Denisov, Dmitri, Dermisek, Radovan, Dieguez, Angel, Dohmae, Takeshi, Dopke, Jens, Dort, Katharina, Du, Yong, Dudar, Bohdan, Dutta, Bhaskar, Dutta, Juhi, Einhaus, Ulrich, Elsen, Eckhard, Endo, Motoi, Eremeev, Grigory, Eren, Engin, Erler, Jens, Esarey, Eric, Everett, Lisa, Golfe, Angeles Faus, Garcia, Marcos Fernandez, Foster, Brian, Fourches, Nicolas, Fouz, Mary-Cruz, Fujii, Keisuke, Fujimoto, Junpei, Torregrosa, Esteban Fullan, Furukawa, Kazuro, Fusayasu, Takahiro, Fuster, Juan, Ganjour, Serguei, Gao, Yuanning, Gaur, Naveen, Geng, Rongli, Georgi, Howard, Gherghetta, Tony, Goldstein, Joel, Goncalves, Dorival, Gonski, Julia, Gonzalo, Tomas, Goto, Takeyoshi, Goto, Toru, Graf, Norman, Grames, Joseph, Grannis, Paul, Gray, Lindsey, Grohsjean, Alexander, Gu, Jiayin, Guler, Yalcin, Gutierrez, Phillip, Haba, Junji, Haber, Howard, Hallford, John, Hamaguchi, Koichi, Han, Tao, Hara, Kazuhiko, Harada, Daisuke, Hashimoto, Koji, Hashino, Katsuya, Hayashi, Masahito, Heinrich, Gudrun, Hidaka, Keisho, Higuchi, Takeo, Hinode, Fujio, Hioki, Zenro, Hirose, Minoru, Hiroshima, Nagisa, Hisano, Junji, Hollik, Wolfgang, Homiller, Samuel, Hong, Sungwoo, Hook, Anson, Horii, Yasuyuki, Hoshina, Hiroki, Hristova, Ivana, Huitu, Katri, Hyakutake, Yoshifumi, Iijima, Toru, Ikematsu, Katsumasa, Ilderton, Anton, Inami, Kenji, Irles, Adrian, Ishikawa, Akimasa, Ishiwata, Koji, Ito, Hayato, Ivanov, Igor, Iwamoto, Sho, Iwamoto, Toshiyuki, Iwasaki, Masako, Iwashita, Yoshihisa, Jia, Haoyi, Morales, Fabricio Jimenez, Joshi, Prakash, Jung, Sunghoon, Kacarevic, Goran, Kagan, Michael, Kakizaki, Mitsuru, Kalinowski, Jan, Kaminski, Jochen, Kanaya, Kazuyuki, Kanemura, Shinya, Kanno, Hayato, Kano, Yuya, Kashiwagi, Shigeru, Kato, Yukihiro, Kawada, Nanami, Kawada, Shin-ichi, Kawagoe, Kiyotomo, Khoze, Valery, Kichimi, Hiromichi, Kim, Doojin, Kitahara, Teppei, Kitano, Ryuichiro, Klamka, Jan, Komamiya, Sachio, Kong, K. C., Konomi, Taro, Kotera, Katsushige, Kou, Emi, Kravchenko, Ilya, Kubo, Kiyoshi, Kubo, Takayuki, Kumaoka, Takuya, Kumar, Ashish, Kumar, Nilanjana, Kunath, Jonas, Kundu, Saumyen, Kunitomo, Hiroshi, Kurata, Masakazu, Kuriki, Masao, Kusenko, Alexander, Lagouri, Theodota, Lankford, Andrew J., Lastovicka-Medin, Gordana, Diberder, Francois Le, Lee, Claire, Liepe, Matthias, Linacre, Jacob, Liptak, Zachary, Lomte, Shivani, Low, Ian, Ma, Yang, Maalouf, Hani, MacFarlane, David, Madison, Brendon, Madlener, Thomas, Maeda, Tomohito, Malek, Paul, Mandal, Sanjoy, Markiewicz, Thomas, Marshall, John, Martens, Aurelien, Martin, Victoria, Martinello, Martina, Rivero, Celso Martinez, Maru, Nobuhito, Matheson, John, Matsumoto, Shigeki, Matsunaga, Hiroyuki, Matsuo, Yutaka, Mawatari, Kentarou, Mbagwu, Johnpaul, McIntosh, Peter, McKeown, Peter, Meade, Patrick, Mekala, Krzysztof, Merkel, Petra, Mihara, Satoshi, Miralles, Víctor, Lopez, Marcos Miralles, Mishima, Go, Mishima, Satoshi, Mistlberger, Bernhard, Mitov, Alexander, Miyabayashi, Kenkichi, Miyamoto, Akiya, Mohanty, Gagan, Monaco, Laura, Mondragon, Myriam, Montgomery, Hugh E., Moortgat-Pick, Gudrid, Morange, Nicolas, Llacer, María Moreno, Moretti, Stefano, Mori, Toshinori, Morii, Toshiyuki, Moroi, Takeo, Morrissey, David, Nachman, Benjamin, Nagano, Kunihiro, Nakajima, Jurina, Nakamura, Eiji, Narita, Shinya, Nath, Pran, Nelson, Timothy, Newbold, David, Niki, Atsuya, Nishimura, Yasuhiro, Nishiyama, Eisaku, Nomura, Yasunori, Nowak, Kacper, Nozaki, Mitsuaki, de Vera, María Teresa Nunez Pardo, Ochoa, Ines, Ogata, Masahito, Ohashi, Satoru, Ohta, Hikaru, Ohta, Shigemi, Ohuchi, Norihito, Oide, Hideyuki, Okada, Nobuchika, Okada, Yasuhiro, Okawa, Shohei, Okayasu, Yuichi, Okugawa, Yuichi, Okugi, Toshiyuki, Okui, Takemichi, Okuyama, Yoshitaka, Omet, Mathieu, Omori, Tsunehiko, Ono, Hiroaki, Onoe, Tomoki, Ootani, Wataru, Otono, Hidetoshi, Ozawa, Shuhei, Griso, Simone Pagan, Papa, Alessandro, Paparella, Rocco, Park, Eun-Kyung, Perez, Gilad, Perez-Lorenzana, Abdel, Peters, Yvonne, Petriello, Frank, Piedra, Jonatan, Porod, Werner, Potter, Christopher, Price, Alan, Radkhorrami, Yasser, Reina, Laura, Reuter, Juergen, Richard, Francois, Riemann, Sabine, Rimmer, Robert, Rizzo, Thomas, Robens, Tania, Ruber, Roger, Jimeno, Alberto Ruiz, Saeki, Takayuki, Saha, Ipsita, Saito, Tomoyuki, Sakaguchi, Makoto, Sakai, Tadakatsu, Sakaki, Yasuhito, Sakurai, Kodai, Salvatico, Riccardo, Salvatore, Fabrizio, San, Yik Chuen, Sandick, Pearl, Sanuki, Tomoyuki, Sasikumar, Kollassery Swathi, Schaefer, Oliver, Schaefer, Ruth, Schneekloth, Uwe, Schoerner-Sadenius, Thomas, Schroeder, Carl, Schuster, Philip, Schwartzman, Ariel, Schwienhorst, Reinhard, Sefkow, Felix, Seiya, Yoshihiro, Sekiguchi, Motoo, Sekizawa, Kazuyuki, Senyo, Katsumi, Sert, Hale, Sertore, Danielev, Settles, Ronald, Shafi, Qaisar, Shahdara, Tetsuo, Haghi, Barmak Shams Es, Sharma, Ashish, Shelton, Jessie, Shepherd-Themistocleous, Claire, Shibuya, Hiroto, Shidara, Tetsuo, Shimomura, Takashi, Shindou, Tetsuo, Shoji, Yutaro, Shu, Jing, Sievers, Ian, Simon, Frank, Singh, Rajeev, Soreq, Yotam, Stanitzki, Marcel, Stapnes, Steinar, Steinhebel, Amanda, Stupak, John, Su, Shufang, Suekane, Fumihiko, Sugamoto, Akio, Sugawara, Yuji, Sugimoto, Satoru, Sugimoto, Yasuhiro, Sugiyama, Hiroaki, Sumino, Yukinari, Sundrum, Raman, Suzuki, Atsuto, Suzuki, Shin, Swiatlowski, Maximilian, Tait, Tim M. P., Takahashi, Shota, Takahashi, Tohru, Takeshita, Tohru, Takeuchi, Michihisa, Takubo, Yosuke, Tanabe, Tomohiko, Tanedo, Philip, Tanimoto, Morimitsu, Tao, Shuichiro, Tata, Xerxes, Tauchi, Toshiaki, Taylor, Geoffrey, Terada, Takahiro, Terunuma, Nobuhiro, Thaler, Jesse, Thea, Alessandro, Tillinger, Finn, Timmermans, Jan, Tobioka, Kohsaku, Toda, Kouichi, Tokiyasu, Atsushi, Toma, Takashi, Torndal, Julie, Tosun, Mehmet, Tsai, Yu-Dai, Tseng, Shih-Yen, Tsumura, Koji, Tuckler, Douglas, Uchida, Yoshiki, Uchiyama, Yusuke, Ueda, Daiki, Ukegawa, Fumihiko, Umemori, Kensei, Urakawa, Junji, Vallee, Claude, Vega, Roberto, Velasco, Liliana, Verdu-Andres, Silvia, Vernieri, Caterina, Vila, Anna, Alvarez, Ivan Vila, Vossebeld, Joost, Vsrms, Raghava, Vukasinovic, Natasa, Wackeroth, Doreen, Wakida, Moe, Wang, Liantao, Washio, Masakazu, Watanabe, Takashi, Watson, Nigel, Watts, Gordon, Weiglein, Georg, Wells, James D., Wenskat, Marc, Westhoff, Susanne, White, Glen, Williams, Ciaran, Willocq, Stephane, Wing, Matthew, Winter, Alasdair, Winter, Marc, Wu, Yongcheng, Xie, Keping, Xu, Tao, Yakovlev, Vyacheslav, Yamada, Shuei, Yamamoto, Akira, Yamamoto, Hitoshi, Yamamoto, Kei, Yamamoto, Yasuchika, Yamanaka, Masato, Yamashita, Satoru, Yamatani, Masahiro, Yamatsu, Naoki, Yasui, Shigehiro, Yoda, Takuya, Yonamine, Ryo, Yoshihara, Keisuke, Yoshioka, Masakazu, Yoshioka, Tamaki, Yuasa, Fukuko, Yumino, Keita, Zerwas, Dirk, Zheng, Ya-Juan, Zhou, Jia, Zhu, Hua Xing, Zobov, Mikhail, and Zomer, Fabian

Subjects
Physics - Accelerator Physics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

The International Linear Collider (ILC) is on the table now as a new global energy-frontier accelerator laboratory taking data in the 2030s. The ILC addresses key questions for our current understanding of particle physics. It is based on a proven accelerator technology. Its experiments will challenge the Standard Model of particle physics and will provide a new window to look beyond it. This document brings the story of the ILC up to date, emphasizing its strong physics motivation, its readiness for construction, and the opportunity it presents to the US and the global particle physics community., Comment: 356 pages, Large pdf file (40 MB) submitted to Snowmass 2021; v2 references to Snowmass contributions added, additional authors; v3 references added, some updates, additional authors

Published
2022

246. First-in-human trial of Stabilizer device in neuroendovascular therapy.

Author

Sakai, Chiaki, Sakai, Nobuyuki, Takayanagi, Ariel, Imamura, Hirotoshi, Ohta, Tsuyoshi, Koyanagi, Masaomi, Goto, Masanori, Fukumitsu, Ryu, Sunohara, Tadashi, Fukui, Nobuyuki, Matsumoto, Shirabe, Akiyama, Tomoaki, Takano, Yuki, Haruyama, Hironori, Go, Koichi, Kajiura, Shinji, Shigeyasu, Masashi, Asakura, Kento, Horii, Ryo, Naramoto, Yuji, Nishii, Rikuo, Yamamoto, Yasuhiro, Teranishi, Kunimasa, Kawade, Satohiro, Imahori, Taichiro, Kaneko, Naoki, and Tateshima, Satoshi

Subjects
Anchor technique, Clinical trial, Device navigation, Exchange method, First-in-human, Stent, Clinical Trials and Supportive Activities, Bioengineering, Patient Safety, Cardiovascular, Neurosciences, Clinical Research, Assistive Technology, First -in -human
Abstract

ObjectivesFlow diverter or stent implantation to intracranial target lesion requires large inner diameter microcatheter navigation. The exchange method using stiff long wire is often necessary if it is difficult to navigate over the regular guidewire. However, this method has an intrinsic risk of vessel damage and may cause severe complications. We investigated the safety and efficacy of a new device, the Stabilizer device for navigation in a first-in-human clinical trial under the Certified Review Board agreement.Materials and methodsThe Stabilizer is a 320 cm length exchange wire with a stent for anchoring and is compatible with a 0.0165" microcatheter. The trial design is a prospective single-arm open-label registry. Inclusion criteria are elective flow diverter treatment or stent-assisted coiling, expected to be difficult to navigate a microcatheter with a regular micro guidewire, and obtained documented consent. The primary endpoint of the study was a hemorrhagic complication.ResultsFive patients were enrolled in this trial. The median age is 52 years, ranges from 41 to 70, and all patients were female. Three aneurysms were located on the internal carotid artery, one on the vertebral artery, and one on the basilar artery. Basilar artery aneurysm was treated by stent-assisted coiling and others were treated by flow diverter deployment. All cases successfully navigate microcatheter for the treatment by the trial method using Stabilizer device without any adverse event.ConclusionsThe results from this first-in-human consecutive five cases show the safety of the Stabilizer device in neuro-endovascular therapy for navigation of devices to the intracranial target lesion.

Published
2023

247. Isovector nucleon form factors from 2+1-flavor dynamical domain-wall lattice QCD at the physical mass

Author

Ohta, Shigemi

Subjects
High Energy Physics - Lattice
Abstract

Nucleon isovector form factors calculated on a 2+1-flavor domain-wall-fermions ensemble with strange and degenerate up and down quarks at physical mass and lattice cut off, $a^{-1}$, of about 1.730(4) GeV, are reported. The ensemble was generated jointly by RBC and UKQCD collaborations with a spatial extent of $48a$ or about 5.5 fm. The form factors are calculated in collaboration with LHP collaboration as well. The resulting shape parameters of the form factors, such as vector-charge mean squared radius, $\langle r_1^2\rangle$, or anomalous magnetic moment, $F_2(0)$ appear less dependent on possible excited-state contaminations than the corresponding charges. Preliminary estimates are $\langle r_1^2\rangle \sim 0.142(13)\, \mbox{fm}^2$ and $F_2(0) \sim 3.22(8)$., Comment: 10 pages, 7 figures, talk presented at the 39th International Symposium on Lattice Field Theory - LATTICE2022, 8th-13th August 2022, Rheinische Friedrich-Wilhelms-Universit\"at Bonn, Bonn, Germany

Published
2022

248. Statistical Study of the Star Formation Efficiency in Bars: Is Star Formation Suppressed in Gas-Rich Bars?

Author

Maeda, Fumiya, Egusa, Fumi, Ohta, Kouji, Fujimoto, Yusuke, and Habe, Asao

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

The dependence of star formation efficiency (SFE) on galactic structures, especially whether the SFE in the bar region is lower than those in the other regions, has recently been debated. We report the SFEs of 18 nearby gas-rich massive star-forming barred galaxies with a large apparent bar major axis ($\geqq 75^{\prime\prime}$). We statistically measure the SFE by distinguishing the center, bar-end, and bar regions for the first time. The molecular gas surface density is derived from archival CO(1-0) and/or CO(2-1) data by assuming a constant CO-to-H$_2$ conversion factor ($\alpha_{\rm CO}$), and the star formation rate surface density is derived from a linear combination of far-ultraviolet and mid-infrared intensities. The angular resolution is $15^{\prime\prime}$, which corresponds to $0.3 - 1.8~\rm kpc$. We find that the ratio of the SFE in the bar to that in the disk was systematically lower than unity (typically $0.6-0.8$), which means that the star formation in the bar is systematically suppressed. Our results are inconsistent with similar recent statistical studies that reported that SFE tends to be independent of galactic structures. This inconsistency can be attributed to the differences in the definition of the bar region, spatial resolution, $\alpha_{\rm CO}$, and sample galaxies. Furthermore, we find a negative correlation between SFE and velocity width of the CO spectrum, which is consistent with the idea that the large dynamical effects, such as strong shocks, large shear, and fast cloud-cloud collisions caused by the noncircular motion of the bar, result in a low SFE., Comment: 27 pages, 11 figures, accepted for publication in ApJ

Published
2022
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249. Study of Staggered Magnetization in the Spin-$S$ Square-Lattice Heisenberg Model Using Spiral Boundary Conditions

Author

Kadosawa, Masahiro, Nakamura, Masaaki, Ohta, Yukinori, and Nishimoto, Satoshi

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We propose an efficient numerical method to obtain local order parameter in two-dimensional systems using spiral boundary conditions. As a benchmark, we first estimate the magnitude of staggered magnetization for the $S=1/2$ XXZ Heisenberg model on a square lattice in the whole range of the XXZ anisotropy by density-matrix renormalization group technique. The validity of our method is confirmed by comparing our results with the previous analytical and numerical studies. Then, as further demonstration, we apply our method to obtain the staggered magnetization for the higher-spin cases from $S=1$ to $S=6$. The accuracy of the obtained results is validated using the series expansion and the spin-wave theory., Comment: 5 pages, 5 figures, supplemental material

Published
2022
Full Text
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250. Barycenters and a law of large numbers in Gromov hyperbolic spaces

Author

Ohta, Shin-ichi

Subjects
Mathematics - Metric Geometry, Mathematics - Optimization and Control, Mathematics - Probability
Abstract

We investigate barycenters of probability measures on Gromov hyperbolic spaces, toward development of convex optimization in this class of metric spaces. We establish a contraction property (the Wasserstein distance between probability measures provides an upper bound of the distance between their barycenters), a deterministic approximation of barycenters of uniform distributions on finite points, and a kind of law of large numbers. These generalize the corresponding results on CAT(0)-spaces, up to additional terms depending on the hyperbolicity constant., Comment: 22 pages; v2: minor revisions

Published
2022

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