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202. Comorbidities, gender-differences and COPD severity: The French Palomb cohort

Author

Raherison, Chantal, primary, Berteaud, Emilie, additional, Bernady, Alain, additional, Casteigt, Julien, additional, Daoudi, Yannick, additional, Dupis, Jean-Michel, additional, Nocent-Eijnaini, Cecilia, additional, Falque, Laurent, additional, Le Guillou, Frédéric, additional, Blanchard, Elodie, additional, Jungmann, Helene, additional, Nguyen, Laurent, additional, Moinard, Jean, additional, Prudhomme, Anne, additional, Ozier, Annaig, additional, Roy, Christophe, additional, Sabatini, Marielle, additional, Sapene, Marc, additional, and Pellet, François, additional

Published
2015
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205. Social Sensing for Psychology

Author

Schmid Mast, Marianne, primary, Gatica-Perez, Daniel, additional, Frauendorfer, Denise, additional, Nguyen, Laurent, additional, and Choudhury, Tanzeem, additional

Published
2015
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207. Alteration of rat fetal cerebral cortex development after prenatal exposure to polychlorinated biphenyls

Author

Naveau, Elise, Pinson, Anneline, Gérard, Arlette, Nguyen, Laurent, Charlier, Corinne, Thomé, Jean-Pierre, Zoeller, R. Thomas, Bourguignon, Jean-Pierre, Parent, Anne-Simone, Naveau, Elise, Pinson, Anneline, Gérard, Arlette, Nguyen, Laurent, Charlier, Corinne, Thomé, Jean-Pierre, Zoeller, R. Thomas, Bourguignon, Jean-Pierre, and Parent, Anne-Simone

Abstract

Polychlorinated biphenyls (PCBs) are environmental contaminants that persist in environment and human tissues. Perinatal exposure to these endocrine disruptors causes cognitive deficits and learning disabilities in children. These effects may involve their ability to interfere with thyroid hormone (TH) action. We tested the hypothesis that developmental exposure to PCBs can concomitantly alter TH levels and TH-regulated events during cerebral cortex development: progenitor proliferation, cell cycle exit and neuron migration. Pregnant rats exposed to the commercial PCB mixture Aroclor 1254 ended gestation with reduced total and free serum thyroxine levels. Exposure to Aroclor 1254 increased cell cycle exit of the neuronal progenitors and delayed radial neuronal migration in the fetal cortex. Progenitor cell proliferation, cell death and differentiation rate were not altered by prenatal exposure to PCBs. Given that PCBs remain ubiquitous, though diminishing, contaminants in human systems, it is important that we further understand their deleterious effects in the brain., Funding Agency:Fonds de la Recherche Scientifique - FNRS, Grant Number: 3.4567.09Belgian Study Group for Pediatric Endocrinology

Published
2014
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209. New insights into the pharmacokinetics of intravenous busulfan in children with sickle cell anemia undergoing bone marrow transplantation

Author

Gaziev, Javid, primary, Isgrò, Antonella, additional, Mozzi, Alessia Francesca, additional, Petain, Aurèlie, additional, Nguyen, Laurent, additional, Ialongo, Cristiano, additional, Dinallo, Vincenzo, additional, Sodani, Pietro, additional, Marziali, Marco, additional, Andreani, Marco, additional, Testi, Manuela, additional, Paciaroni, Katia, additional, Gallucci, Cristiano, additional, De Angelis, Gioia, additional, Alfieri, Cecilia, additional, Ribersani, Michela, additional, and Lucarelli, Guido, additional

Published
2014
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211. Pharmacokinetics/Pharmacodynamic Relationship in Busulfan Conditioning Regimen: Results from a Large Pediatric Cohort Undergoing Hematopoietic Stem-Cell Transplantation

Author

Paci, Angelo, primary, Neven, Benedicte, additional, Poinsignon, Vianney, additional, Faivre, Laura, additional, Bourget, Philippe, additional, Broutin, Sophie, additional, Dufour, Christelle, additional, Dalle, Jean-Hugues, additional, Galambrun, Claire, additional, Devictor, Bénédicte, additional, Bleyzac, Nathalie, additional, Kemmel, Veronique, additional, De Berranger, Eva, additional, Gandemer, Virginie, additional, Vannier, Jean Pierre, additional, Ranarivelo, Jean Pierre, additional, Jubert, Charlotte, additional, Pétain, Aurélie, additional, Benhamou, Ellen, additional, Nguyen, Laurent, additional, Moshous, Despina, additional, and Vassal, Gilles, additional

Published
2014
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215. MicroRNA Targeting of CoREST Controls Polarization of Migrating Cortical Neurons

Author

Volvert, Marie-Laure, primary, Prévot, Pierre-Paul, additional, Close, Pierre, additional, Laguesse, Sophie, additional, Pirotte, Sophie, additional, Hemphill, James, additional, Rogister, Florence, additional, Kruzy, Nathalie, additional, Sacheli, Rosalie, additional, Moonen, Gustave, additional, Deiters, Alexander, additional, Merkenschlager, Matthias, additional, Chariot, Alain, additional, Malgrange, Brigitte, additional, Godin, Juliette D., additional, and Nguyen, Laurent, additional

Published
2014
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217. Calibration of financial models by relative entropy minimization and models with jumps

Author

Nguyen, Laurent, Ecole des Ponts ParisTech, Jourdain Benjamin, and PASTEL, Admin

Subjects
generalized I-projection, smile de volatilité, relative entropy, méthode de Monte-Carlo, [MATH] Mathematics [math], calibration de modèles, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Monte-Carlo method, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, volatility smile, contrôle optimal des processus de diffusion avec sauts, calibration of models, I-projection génralisée, moment problem, optimal control of jump diffusion processes, problème de moments, [INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation, [MATH]Mathematics [math], [SHS.ECO] Humanities and Social Sciences/Economics and Finance, entropie relative
Abstract

The smile observed in option markets is the evidence of the deficiency of the Black and Scholes model. With the necessity to find a more relevant model of financial assets comes the requirement of its calibration. This is the subjetc of the present work. A calibration technique of financial models, based on the minimization of relative entropy, has been recently suggested in the framework of Monte carlo. We have proved the convergence and stability of this technique and extended the results to criteria more general than relative entropy. The martingale constraint on the underlying necessary to insure No Free Lunch has been examined from the point of view of moment problems.In the second part we have considered a simple model of crashes by introducing jumps in the volatily process. The quadratic risk has benn computed and approximate close formulae of the smile have been obtained for the calibration.Finally we have used the relative entropy criterion to calibrate the jump intensity of a jump diffusion model. The stability of this method has been proved by means of optimal control techniques combined with the implicit function theorem., Le smile de volatilité implicite observé sur les marchés d'options traduit l'insuffisance du modèle de Black et Scholes. Avec la nécessité d'élaborer un modèle d'actif financier plus satisfaisant, vient celle de sa calibration, objet de cette thèse. La calibration de modèles financiers par minimisation de lentropie relative a été proposée récemment dans le cadre de la méthode de Monte Carlo. On a étudié la convergence et la stabilité de cette méthode et on a étendu les résultats à des critères plus généraux que lentropie relative. La prise en compte des contraintes sur le sous-jacent assurant labsence dopportunité darbitrage a été abordée sous langle dun problème de moments.Dans la seconde partie, on a considéré un modèle simple du phénomène de krach en introduisant en particulier des sauts dans la volatilité du sous-jacent. On a calculé le risque quadratique et effectué un développement approché du smile utile pour la calibration.Finalement, dans la troisième partie, on utilise lentropie relative pour calibrer lintensité des sauts dun modèle de diffusion avec sauts et volatilité locale. La stabilité de la méthode a été prouvée grâce à des techniques de contrôle optimal ainsi quau théorème des fonctions implicites.

Published
2003

218. Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells

Author

Defourny, Jean, Poirrier, Anne-Lise, Lallemend, Francois, Sanchez, Susana Mateo, Neef, Jakob, Vanderhaeghen, Pierre, Soriano, Eduardo, Peuckert, Christiane, Kullander, Klas, Fritzsch, Bernd, Nguyen, Laurent, Moonen, Gustave, Moser, Tobias, Malgrange, Brigitte, Defourny, Jean, Poirrier, Anne-Lise, Lallemend, Francois, Sanchez, Susana Mateo, Neef, Jakob, Vanderhaeghen, Pierre, Soriano, Eduardo, Peuckert, Christiane, Kullander, Klas, Fritzsch, Bernd, Nguyen, Laurent, Moonen, Gustave, Moser, Tobias, and Malgrange, Brigitte

Abstract

Hearing requires an optimal afferent innervation of sensory hair cells by spiral ganglion neurons in the cochlea. Here we report that complementary expression of ephrin-A5 in hair cells and EphA4 receptor among spiral ganglion neuron populations controls the targeting of type I and type II afferent fibres to inner and outer hair cells, respectively. In the absence of ephrin-A5 or EphA4 forward signalling, a subset of type I projections aberrantly overshoot the inner hair cell layer and invade the outer hair cell area. Lack of type I afferent synapses impairs neurotransmission from inner hair cells to the auditory nerve. By contrast, radial shift of type I projections coincides with a gain of presynaptic ribbons that could enhance the afferent signalling from outer hair cells. Ephexin-1, cofilin and myosin light chain kinase act downstream of EphA4 to induce type I spiral ganglion neuron growth cone collapse. Our findings constitute the first identification of an Eph/ephrin-mediated mutual repulsion mechanism responsible for specific sorting of auditory projections in the cochlea.

Published
2013
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219. Activation de la CDK4, clef de l'engagement du cycle cellulaire et carrefour des voies oncogéniques: évaluation de l'implication de la kinase activatrice des CDKs (CAK) et des phosphorylations de p21

Author

Roger, Pierre P., Vassart, Gilbert, Nguyen, Laurent, Sotiriou, Christos, Perret, Jason, Martiat, Philippe, Decottignies, Anabelle, Bisteau, Xavier, Roger, Pierre P., Vassart, Gilbert, Nguyen, Laurent, Sotiriou, Christos, Perret, Jason, Martiat, Philippe, Decottignies, Anabelle, and Bisteau, Xavier

Abstract

Confidentiel, Doctorat en Sciences biomédicales et pharmaceutiques, info:eu-repo/semantics/nonPublished

Published
2013

220. p27Kip1Modulates Axonal Transport by Regulating α-Tubulin Acetyltransferase 1 Stability

Author

Morelli, Giovanni, Even, Aviel, Gladwyn-Ng, Ivan, Le Bail, Romain, Shilian, Michal, Godin, Juliette D., Peyre, Elise, Hassan, Bassem A., Besson, Arnaud, Rigo, Jean-Michel, Weil, Miguel, Brône, Bert, and Nguyen, Laurent

Abstract

The protein p27Kip1plays roles that extend beyond cell-cycle regulation during cerebral cortex development, such as the regulation of neuronal migration and neurite branching via signaling pathways that converge on the actin and microtubule cytoskeletons. Microtubule-dependent transport is essential for the maturation of neurons and the establishment of neuronal connectivity though synapse formation and maintenance. Here, we show that p27Kip1controls the transport of vesicles and organelles along the axon of mice cortical projection neurons in vitro. Moreover, suppression of the p27Kip1ortholog, dacapo, in Drosophila melanogasterdisrupts axonal transport in vivo, leading to the reduction of locomotor activity in third instar larvae and adult flies. At the molecular level, p27Kip1stabilizes the α-tubulin acetyltransferase 1, thereby promoting the acetylation of microtubules, a post-translational modification required for proper axonal transport.

Published
2018
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223. Régulation du transport des mitochondries dans les neurones et expression des moteurs moléculaires dans le cortex humain: implication pour l'étude des anomalies du transport axoplasmique dans la maladie d'Alzheimer

Author

Brion, Jean Pierre, Gevenois, Pierre-Alain, Goldman, Serge, Pandolfo, Massimo, Vanderhaeghen, Pierre, Buée, Luc, Nguyen, Laurent, Morel, Marina, Brion, Jean Pierre, Gevenois, Pierre-Alain, Goldman, Serge, Pandolfo, Massimo, Vanderhaeghen, Pierre, Buée, Luc, Nguyen, Laurent, and Morel, Marina

Abstract

La maladie d’Alzheimer est la maladie neurodégénérative la plus fréquente dans le monde industrialisé. Sur le plan neuropathologique, cette maladie est caractérisée par deux types de lésions :les plaques séniles et les dégénérescences neurofibrillaires. Des observations morphologiques précédentes ont permis de mettre en évidence des anomalies du transport axoplasmique dans les neurones chez les patients atteints de la maladie d’Alzheimer. Les mécanismes menant à cette perturbation du transport axoplasmique ne sont pas encore bien établis. La glycogen synthase kinase-3β (GSK-3β) et la cyclin-dependent kinase 5 (Cdk5) associée à son activateur pathologique p25, sont deux kinases clés dont la dérégulation intervient dans la pathogenèse de la maladie d’Alzheimer (MA). Nous avons émis l'hypothèse que ces kinases pourraient jouer un rôle dans la perturbation du transport axoplasmique dans cette maladie.Dans la première partie de notre travail, nous nous sommes intéressés à l’effet de la GSK-3β et de Cdk5/p25 sur la croissance des neurites (un processus dépendant du transport axoplasmique) dans un modèle cellulaire, les PC12 différenciées prétraitées au NGF. La surexpression de GSK-3β et de p25 provoque une importante réduction de la croissance neuritique dans ces cellules. Par western blot, nous avons montré que cette réduction est associée à des modifications post-traductionnelles des protéines impliquées dans la régulation du cytosquelette. Ces modifications sont la phosphorylation de la protéine tau et des neurofilaments et l’acétylation de la tubuline α.Cette étude indique donc que la GSK-3β et la protéine p25 contrôlent négativement la croissance neuritique.Dans la deuxième partie de notre travail, afin d’étudier la relation entre ces kinases et le transport axoplasmique, nous avons analysé dans des neurones en culture l’effet d’une augmentation d’activité de la GSK-3β et de Cdk5/p25 sur le transport des mitochondries.Pour étudier le déplaceme, Doctorat en Sciences biomédicales et pharmaceutiques, info:eu-repo/semantics/nonPublished

Published
2011

224. Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate

Author

Westerlund, Nina, Zdrojewska, Justyna, Padzik, Artur, Komulainen, Emilia, Björkblom, Benny, Rannikko, Emmy, Tararuk, Tanya, Garcia-Frigola, Cristina, Sandholm, Jouko, Nguyen, Laurent, Kallunki, Tuula, Courtney, Michael J, Coffey, Eleanor T, Westerlund, Nina, Zdrojewska, Justyna, Padzik, Artur, Komulainen, Emilia, Björkblom, Benny, Rannikko, Emmy, Tararuk, Tanya, Garcia-Frigola, Cristina, Sandholm, Jouko, Nguyen, Laurent, Kallunki, Tuula, Courtney, Michael J, and Coffey, Eleanor T

Abstract

Cell migration is the consequence of the sum of positive and negative regulatory mechanisms. Although appropriate migration of neurons is a principal feature of brain development, the negative regulatory mechanisms remain obscure. We found that JNK1 was highly active in developing cortex and that selective inhibition of JNK in the cytoplasm markedly increased both the frequency of exit from the multipolar stage and radial migration rate and ultimately led to an ill-defined cellular organization. Moreover, regulation of multipolar-stage exit and radial migration in Jnk1−/− (also known as Mapk8) mice, resulted from consequential changes in phosphorylation of the microtubule regulator SCG10 (also called stathmin-2). Expression of an SCG10 mutant that mimics the JNK1-phosphorylated form restored normal migration in the brains of Jnk1−/− mouse embryos. These findings indicate that the phosphorylation of SCG10 by JNK1 is a fundamental mechanism that governs the transition from the multipolar stage and the rate of neuronal cell movement during cortical development.

Published
2011
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225. Etude de l'expression du gène EphA7 et de son ligand ephrine-A5 dans le cortex en développement

Author

Vanderhaeghen, Pierre, Parmentier, Marc, de Kerchove d'Exaerde, Alban, Rijli, Filippo F.M., Brion, Jean Pierre, Nguyen, Laurent, Pandolfo, Massimo, Pietri, Sandra, Vanderhaeghen, Pierre, Parmentier, Marc, de Kerchove d'Exaerde, Alban, Rijli, Filippo F.M., Brion, Jean Pierre, Nguyen, Laurent, Pandolfo, Massimo, and Pietri, Sandra

Abstract

Le cortex cérébral constitue l’une des structures les plus évoluées et complexes de notre cerveau. Sa surface est divisée en de nombreuses aires fonctionnelles. La mise en place des aires corticales dépend à la fois de facteurs intrinsèques comme la sécrétion de morphogènes ou l’expression en gradient de différents facteurs de transcription, mais elle dépend aussi de facteurs extrinsèques au cortex, en particulier l'innervation par le thalamus. Les ephrines et leurs récepteurs Eph constituent une famille multigénique de facteurs de signalisation impliqués dans divers événements clé du développement cortical où ils sont exprimés selon des profils spatio-temporels complexes. Aux stades tardifs du développement, EphA7 et l’ephrine-A5 sont exprimés en gradients complémentaires au sein de chaque territoire des aires présomptives, constituant ainsi les marqueurs les plus précoces de ces aires corticales. Par la combinaison d’approches in-vitro utilisant la technique d’électroporation focale de tranches corticales embryonnaires, puis in-vivo en utilisant la technique de transgénèse d’addition, nous avons identifié une séquence régulatrice de EphA7 appelée pA7, capable de mimer l’expression endogène de EphA7 au sein du télencéphale dorsal en développement. La lignée de souris pA7-GFP ainsi générée exprime la GFP spécifiquement au sein du télencéphale dorsal durant les stades précoces. Aux stades périnataux cette expression se régionalise au sein de la plaque corticale de chacune des aires présomptives selon des gradients récapitulant ceux observés pour EphA7. Nous avons ensuite purifié des neurones exprimant différents niveaux d’EphA7 par la technique de FACS «Fluorescence-Activated Cell Sorting » et l’analyse de leur transcriptome nous a permis de trouver un grand nombre de gènes différentiellement exprimés. Tous ceux testés par la technique d’hybridation in situ sont exprimés selon un gradient latéral fort et médial faible dans le cortex pariétal, similaire à celui, Doctorat en Sciences biomédicales et pharmaceutiques, info:eu-repo/semantics/nonPublished

Published
2010

226. Period 2 regulates neural stem/progenitor cell proliferation in the adult hippocampus

Author

Borgs, Laurence, Beukelaers, Pierre, Vandenbosch, Renaud, Nguyen, Laurent, Moonen, Gustave, Maquet, Pierre, Albrecht, Urs, Belachew, Shibeshih, Malgrange, Brigitte, Borgs, Laurence, Beukelaers, Pierre, Vandenbosch, Renaud, Nguyen, Laurent, Moonen, Gustave, Maquet, Pierre, Albrecht, Urs, Belachew, Shibeshih, and Malgrange, Brigitte

Abstract

Background: Newborn granule neurons are generated from proliferating neural stem/progenitor cells and integrated into mature synaptic networks in the adult dentate gyrus of the hippocampus. Since light/dark variations of the mitotic index and DNA synthesis occur in many tissues, we wanted to unravel the role of the clock-controlled Period2 gene (mPer2) in timing cell cycle kinetics and neurogenesis in the adult DG.Results: In contrast to the suprachiasmatic nucleus, we observed a non-rhythmic constitutive expression of mPER2 in the dentate gyrus. We provide evidence that mPER2 is expressed in proliferating neural stem/progenitor cells (NPCs) and persists in early post-mitotic and mature newborn neurons from the adult DG. In vitro and in vivo analysis of a mouse line mutant in the mPer2 gene (Per2Brdm1), revealed a higher density of dividing NPCs together with an increased number of immature newborn neurons populating the DG. However, we showed that the lack of mPer2 does not change the total amount of mature adult-generated hippocampal neurons, because of a compensatory increase in neuronal cell death.Conclusion: Taken together, these data demonstrated a functional link between the constitutive expression of mPER2 and the intrinsic control of neural stem/progenitor cells proliferation, cell death and neurogenesis in the dentate gyrus of adult mice

Published
2009

229. Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells

Author

Defourny, Jean, primary, Poirrier, Anne-Lise, additional, Lallemend, François, additional, Mateo Sánchez, Susana, additional, Neef, Jakob, additional, Vanderhaeghen, Pierre, additional, Soriano, Eduardo, additional, Peuckert, Christiane, additional, Kullander, Klas, additional, Fritzsch, Bernd, additional, Nguyen, Laurent, additional, Moonen, Gustave, additional, Moser, Tobias, additional, and Malgrange, Brigitte, additional

Published
2013
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231. Optimization of sono-electrochemical oxidation of ibuprofen in wastewater.

Author

Tran, Nam, Drogui, Patrick, Nguyen, Laurent, and Brar, Satinder K.

Subjects
ELECTROCHEMICAL analysis, IBUPROFEN, WASTEWATER treatment
Abstract

The decomposition of ibuprofen in synthetic solution and in municipal wastewater effluent was investigated using an electro-sonochemical reactor. The concept of coupling ultrasonication and electrooxidation (EO–US) treatment for ibuprofen removal was demonstrated. The degree of synergy was 5.26%. Several factors such as current intensity, ultrasound power, treatment time were investigated. A factorial experimental design was used for determining the influent parameters on the ibuprofen degradation. The current intensity and treatment time were the main influent parameters on the degradation rate. Using a 2 3 factorial matrix, the best performance of ibuprofen degradation (77% of removal) was obtained by selecting 40 W of ultrasound power, a current intensity of 5.0 A and a treatment time of 120 min. Subsequently, the optimal experimental parameters for ibuprofen degradation have been investigated by using a central composite methodology. Under these, optimal conditions determined by this method, EO–US can be applied to oxidize ibuprofen in municipal wastewater effluent (up to 90% of degradation) while using a current intensity of 4.09 A for a period of 110 min and by applying 20 W of ultrasound power. [ABSTRACT FROM AUTHOR]

Published
2015
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235. Phase II study of vinorelbine and continuous low doses cyclophosphamide in children and young adults with a relapsed or refractory malignant solid tumour: Good tolerance profile and efficacy in rhabdomyosarcoma – A report from the Société Française des Cancers et leucémies de l’Enfant et de l’adolescent (SFCE)

Author

Minard-Colin, Véronique, primary, Ichante, Jean-Laurent, additional, Nguyen, Laurent, additional, Paci, Angelo, additional, Orbach, Daniel, additional, Bergeron, Christophe, additional, Defachelles, Anne-Sophie, additional, André, Nicolas, additional, Corradini, Nadège, additional, Schmitt, Claudine, additional, Tabone, Marie-Dominique, additional, Blouin, Pascale, additional, Sirvent, Nicolas, additional, Goma, Gisele, additional, Geoerger, Birgit, additional, and Oberlin, Odile, additional

Published
2012
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236. p27Kip1 Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration

Author

Godin, Juliette D., primary, Thomas, Noémie, additional, Laguesse, Sophie, additional, Malinouskaya, Lina, additional, Close, Pierre, additional, Malaise, Olivier, additional, Purnelle, Audrey, additional, Raineteau, Olivier, additional, Campbell, Kenneth, additional, Fero, Matthew, additional, Moonen, Gustave, additional, Malgrange, Brigitte, additional, Chariot, Alain, additional, Metin, Christine, additional, Besson, Arnaud, additional, and Nguyen, Laurent, additional

Published
2012
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237. DERP6 (ELP5) and C3ORF75 (ELP6) Regulate Tumorigenicity and Migration of Melanoma Cells as Subunits of Elongator

Author

Close, Pierre, primary, Gillard, Magali, additional, Ladang, Aurélie, additional, Jiang, Zheshen, additional, Papuga, Jessica, additional, Hawkes, Nicola, additional, Nguyen, Laurent, additional, Chapelle, Jean-Paul, additional, Bouillenne, Fabrice, additional, Svejstrup, Jesper, additional, Fillet, Marianne, additional, and Chariot, Alain, additional

Published
2012
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239. Pharmacokinetic Behavior and Appraisal of Intravenous Busulfan Dosing in Infants and Older Children

Author

Paci, Angelo, primary, Vassal, Gilles, additional, Moshous, Despina, additional, Dalle, Jean-Hugues, additional, Bleyzac, Nathalie, additional, Neven, Bénédicte, additional, Galambrun, Claire, additional, Kemmel, Véronique, additional, Abdi, Zeinab D., additional, Broutin, Sophie, additional, Pétain, Aurélie, additional, and Nguyen, Laurent, additional

Published
2012
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241. Cdk6-Dependent Regulation of G1 Length Controls Adult Neurogenesis

Author

Beukelaers, Pierre, primary, Vandenbosch, Renaud, additional, Caron, Nicolas, additional, Nguyen, Laurent, additional, Belachew, Shibeshih, additional, Moonen, Gustave, additional, Kiyokawa, Hiroaki, additional, Barbacid, Mariano, additional, Santamaria, David, additional, and Malgrange, Brigitte, additional

Published
2011
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242. Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate

Author

Westerlund, Nina, primary, Zdrojewska, Justyna, additional, Padzik, Artur, additional, Komulainen, Emilia, additional, Björkblom, Benny, additional, Rannikko, Emmy, additional, Tararuk, Tanya, additional, Garcia-Frigola, Cristina, additional, Sandholm, Jouko, additional, Nguyen, Laurent, additional, Kallunki, Tuula, additional, Courtney, Michael J, additional, and Coffey, Eleanor T, additional

Published
2011
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243. Weight-based strategy of dose administration in children using intravenous busulfan: Clinical and pharmacokinetic results

Author

Michel, Gérard, primary, Valteau-Couanet, Dominique, additional, Gentet, Jean-Claude, additional, Esperou, Hélène, additional, Socié, Gérard, additional, Méchinaud, Françoise, additional, Doz, François, additional, Neven, Bénédicte, additional, Bertrand, Yves, additional, Galambrun, Claire, additional, Demeocq, François, additional, Yakouben, Karima, additional, Bordigoni, Pierre, additional, Frappaz, Didier, additional, Nguyen, Laurent, additional, and Vassal, Gilles, additional

Published
2011
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244. Screening for Potential Covariates Influencing the Pharmacokinetics of Intravenous Busulfan: Results From a Large Pediatric Cohort Undergoing Hematopoietic Stem-Cell Transplantation

Author

Abdi, Zeinab Daher, primary, Paci, Angelo, additional, Moshous, Despina, additional, Dalle, Jean-Hugues, additional, Bleyzac, Nathalie, additional, Neven, Benedicte, additional, Galambrun, Claire, additional, Kemmel, Véronique, additional, Pétain, Aurélie, additional, Broutin, Sophie, additional, Nguyen, Laurent, additional, and Vassal, Gilles, additional

Published
2010
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247. Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis

Author

Godin, Juliette D., primary, Colombo, Kelly, additional, Molina-Calavita, Maria, additional, Keryer, Guy, additional, Zala, Diana, additional, Charrin, Bénédicte C., additional, Dietrich, Paula, additional, Volvert, Marie-Laure, additional, Guillemot, François, additional, Dragatsis, Ioannis, additional, Bellaiche, Yohanns, additional, Saudou, Frédéric, additional, Nguyen, Laurent, additional, and Humbert, Sandrine, additional

Published
2010
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248. Novel pharmacokinetic behavior of intravenous busulfan in children with thalassemia undergoing hematopoietic stem cell transplantation: a prospective evaluation of pharmacokinetic and pharmacodynamic profile with therapeutic drug monitoring

Author

Gaziev, Javid, primary, Nguyen, Laurent, additional, Puozzo, Christian, additional, Mozzi, Alessia Francesca, additional, Casella, Marialuisa, additional, Perrone Donnorso, Michela, additional, Gravina, Paolo, additional, Sodani, Pietro, additional, Marziali, Marco, additional, Isgrò, Antonella, additional, Simone, Maria Domenica, additional, Andreani, Marco, additional, Formosa, Amanda, additional, Testi, Manuela, additional, Federici, Giorgio, additional, Bernardini, Sergio, additional, and Lucarelli, Guido, additional

Published
2010
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