1,961 results on '"Nardiello, A."'
Search Results
202. A New Recognition Procedure for Palmprint Features Extraction from Ultrasound Images.
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Donatella Nardiello and Antonio Iula
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- 2017
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203. Students React to the Ongoing Conflict in Gaza - The Greyhound
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Nardiello, Andrew
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Israel-Arab conflicts ,News, opinion and commentary ,Sports and fitness - Abstract
Byline: Andrew Nardiello content'class='sno-story-body-content sno-no-cap'> Enrique Muchacho The conflict in Gaza continues on the battlefield, as does the heated debate at universities around the world, including Loyola. Raneem Odeh '26, [...]
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- 2023
204. Loyola's Response to The Morgan State Shooting Was a Systemic Failure - The Greyhound
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Nardiello, Andrew
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News, opinion and commentary ,Sports and fitness - Abstract
Byline: Andrew Nardiello content'class='sno-story-body-content sno-no-cap'> The following represents the opinion of the student reporter and does not represent the views of Loyola University Maryland, the Greyhound, or Loyola University's Department [...]
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- 2023
205. Milk authenticity by ion-trap proteomics following multi-enzyme digestion
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Nardiello, Donatella, Natale, Anna, Palermo, Carmen, Quinto, Maurizio, and Centonze, Diego
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- 2018
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206. Rapid method for the quantification of 13 sulphonamides in milk by conventional high-performance liquid chromatography with diode array ultraviolet detection using a column packed with core-shell particles
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Armentano, Antonio, Summa, Simona, Lo Magro, Sonia, Palermo, Carmen, Nardiello, Donatella, Centonze, Diego, and Muscarella, Marilena
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- 2018
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207. Metal content in the liver, kidney, and feathers of Northern gannets, Morus bassanus, sampled on the Spanish coast
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Nardiello, Veronica, Fidalgo, Luis Eusebio, López-Beceiro, Ana, Bertero, Alessia, Martínez-Morcillo, Salomé, Míguez, María Prado, Soler, Francisco, Caloni, Francesca, and Pérez-López, Marcos
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- 2019
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208. JWST unveils the brown dwarf sequence of 47 Tucanæ
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Domenico NARDIELLO, Luigi Bedin, and Massimo Griggio
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Astrophysics - Solar and Stellar Astrophysics ,Space and Planetary Science ,Astrophysics of Galaxies (astro-ph.GA) ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Solar and Stellar Astrophysics (astro-ph.SR) - Abstract
We have developed a technique to restore scientific usage in compromised (publicly-available) images collected with the James Webb Space Telescope (JWST) of the Galactic globular cluster NGC 104 (47 Tucanae). In spite of the degradation and limited data, we were able to recover photometry and astrometry for the coolest stellar objects ever observed within a globular cluster, possibly unveiling the brightest part of the brown dwarf (BD) sequence. This is supported by: (i) proper motion membership, derived by the comparison with positions obtained from Hubble Space Telescope archival early epochs; (ii) the predicted location of the BD sequence; and (iii) the mass function for low-mass stars derived from models. Future JWST observations will provide the necessary deep and precise proper motions to confirm the nature of the here-identified BD candidates belonging to this globular cluster., Comment: 7 pages, 4 figures (+1 bonus), 1 table. Accepted for publication in MNRAS Letter on February 9, 2023
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- 2023
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209. The HST Large Programme on NGC 6752 – II. Multiple populations at the bottom of the main sequence probed in NIR
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A P Milone, A F Marino, L R Bedin, J Anderson, D Apai, A Bellini, A Dieball, M Salaris, M Libralato, D Nardiello, P Bergeron, A J Burgasser, J M Rees, R M Rich, and H B Richer
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- 2019
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210. A deep view of a fossil relic in the Galactic bulge: the Globular Cluster HP 1
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L O Kerber, M Libralato, S O Souza, R A P Oliveira, S Ortolani, A Pérez-Villegas, B Barbuy, B Dias, E Bica, and D Nardiello
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- 2019
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211. The Interferometric Binary ϵ Cnc in Praesepe: Precise Masses and Age
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Leslie M. Morales, Eric L. Sandquist, Gail H. Schaefer, Christopher D. Farrington, Robert Klement, Luigi R. Bedin, Mattia Libralato, Luca Malavolta, Domenico Nardiello, Jerome A. Orosz, John D. Monnier, Stefan Kraus, Jean-Baptiste Le Bouquin, Narsireddy Anugu, Theo ten Brummelaar, Claire L. Davies, Jacob Ennis, Tyler Gardner, and Cyprien Lanthermann
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- 2022
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212. A new standardized data collection system for brain stereotactic external radiotherapy: the PRE.M.I.S.E project
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Silvia Chiesa, Barbara Tolu, Silvia Longo, Barbara Nardiello, Nikola Dino Capocchiano, Federica Rea, Luca Capone, Gerardina Stimato, Roberto Gatta, Alessandro Pacchiarotti, Mariangela Massaccesi, Giuseppe Minniti, Francesco Cellini, Andrea Damiani, Mario Balducci, Piercarlo Gentile, Vincenzo Valentini, and Federico Bianciardi
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big data ,brain ,personalized medicine ,predictive model ,stereotactic ,Medicine ,Medicine (General) ,R5-920 - Abstract
Background: In recent years, novel radiation therapy techniques have moved clinical practice toward tailored medicine. An essential role is played by the decision support system, which requires a standardization of data collection. The Aim of the Prediction Models In Stereotactic External radiotherapy (PRE.M.I.S.E.) project is the implementation of systems that analyze heterogeneous datasets. This article presents the project design, focusing on brain stereotactic radiotherapy (SRT). Materials & methods: First, raw ontology was defined by exploiting semiformal languages (block and entity relationship diagrams) and the natural language; then, it was transposed in a Case Report Form, creating a storage system. Results: More than 130 brain SRT’s variables were selected. The dedicated software Beyond Ontology Awareness (BOA-Web) was set and data collection is ongoing. Conclusion: The PRE.M.I.S.E. project provides standardized data collection for a specific radiation therapy technique, such as SRT. Future aims are: including other centers and validating an extracranial SRT ontology.
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- 2020
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213. Multifaceted Analyses of Isolated Mitochondria Establish the Anticancer Drug 2-Hydroxyoleic Acid as an Inhibitor of Substrate Oxidation and an Activator of Complex IV-Dependent State 3 Respiration
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Kumudesh Mishra, Mária Péter, Anna Maria Nardiello, Guy Keller, Victoria Llado, Paula Fernandez-Garcia, Ulf D. Kahlert, Dinorah Barasch, Ann Saada, Zsolt Török, Gábor Balogh, Pablo V. Escriba, Stefano Piotto, and Or Kakhlon
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2-hydroxyoleic acid ,mitochondria ,molecular dynamics ,respiration ,glycolysis ,shotgun lipidomics ,Cytology ,QH573-671 - Abstract
The synthetic fatty acid 2-hydroxyoleic acid (2OHOA) has been extensively investigated as a cancer therapy mainly based on its regulation of membrane lipid composition and structure, activating various cell fate pathways. We discovered, additionally, that 2OHOA can uncouple oxidative phosphorylation, but this has never been demonstrated mechanistically. Here, we explored the effect of 2OHOA on mitochondria isolated by ultracentrifugation from U118MG glioblastoma cells. Mitochondria were analyzed by shotgun lipidomics, molecular dynamic simulations, spectrophotometric assays for determining respiratory complex activity, mass spectrometry for assessing beta oxidation and Seahorse technology for bioenergetic profiling. We showed that the main impact of 2OHOA on mitochondrial lipids is their hydroxylation, demonstrated by simulations to decrease co-enzyme Q diffusion in the liquid disordered membranes embedding respiratory complexes. This decreased co-enzyme Q diffusion can explain the inhibition of disjointly measured complexes I–III activity. However, it doesn’t explain how 2OHOA increases complex IV and state 3 respiration in intact mitochondria. This increased respiration probably allows mitochondrial oxidative phosphorylation to maintain ATP production against the 2OHOA-mediated inhibition of glycolytic ATP production. This work correlates 2OHOA function with its modulation of mitochondrial lipid composition, reflecting both 2OHOA anticancer activity and adaptation to it by enhancement of state 3 respiration.
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- 2022
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214. Data from the analytical performance of the Abaxis Piccolo Xpress point of care analyzer in whole blood, serum, and plasma
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Kazunori Murata, Laurel Glaser, Mary Nardiello, Lakshmi V. Ramanathan, and Dean C. Carlow
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Science (General) ,Q1-390 - Abstract
The objective of this study was to examine the analytical performance of 14 comprehensive metabolic panel analytes on the Abaxis Piccolo Xpress® Point of Care analyzer in serum, plasma, and whole blood. A method comparison was performed on all three specimen types intended for use on the Piccolo Xpress®: serum, heparinized plasma, and whole blood. This data is also presented in Murata et al. (2015) [1]. This article includes the actual Bland-Altman bias plots of the difference in results obtained for analytes in the comprehensive metabolic panel from the Abaxis Piccolo Xpress and the comparison instrument, the Ortho Vitros. Keywords: Clinical chemistry, Point-of care testing
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- 2018
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215. Morphofunctional Investigation in a Transgenic Mouse Model of Alzheimer’s Disease: Non-Reactive Astrocytes Are Involved in Aβ Load and Reactive Astrocytes in Plaque Build-Up
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Lana, Daniele, primary, Branca, Jacopo Junio Valerio, additional, Delfino, Giovanni, additional, Giovannini, Maria Grazia, additional, Casamenti, Fiorella, additional, Nardiello, Pamela, additional, Bucciantini, Monica, additional, Stefani, Massimo, additional, Zach, Petr, additional, Zecchi-Orlandini, Sandra, additional, and Nosi, Daniele, additional
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- 2023
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216. The GAPS Programme at TNG
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Sozzetti, A., primary, Pinamonti, M., additional, Damasso, M., additional, Desidera, S., additional, Biazzo, K., additional, Bonomo, A. S., additional, Nardiello, D., additional, Gratton, R., additional, Lanza, A. F., additional, Malavolta, L., additional, Giacobbe, P., additional, Affer, L., additional, Bignamini, A., additional, Borsa, F., additional, Boschin, W., additional, Brogi, M., additional, Cabona, L., additional, Claudi, R., additional, Covino, E., additional, Di Fabrizio, L., additional, Ghedina, A., additional, Harutyunyan, A., additional, Knapic, C., additional, Maldonado, J., additional, Maggio, A., additional, Mancini, L., additional, Mantovan, G., additional, Marzari, F., additional, Messina, S., additional, Micela, G., additional, Molinari, E., additional, Montalto, M., additional, Naponiello, L., additional, Pagano, I., additional, Pedani, M., additional, Piotto, G., additional, Poretti, E., additional, Scandariato, G., additional, Silvotti, R., additional, and Turrini, D., additional
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- 2023
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217. A super-massive Neptune-sized planet
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Naponiello, Luca, primary, Mancini, Luigi, additional, Sozzetti, Alessandro, additional, Bonomo, Aldo S., additional, Morbidelli, Alessandro, additional, Dou, Jingyao, additional, Zeng, Li, additional, Leinhardt, Zoe M., additional, Biazzo, Katia, additional, Cubillos, Patricio E., additional, Pinamonti, Matteo, additional, Locci, Daniele, additional, Maggio, Antonio, additional, Damasso, Mario, additional, Lanza, Antonino F., additional, Lissauer, Jack J., additional, Collins, Karen A., additional, Carter, Philip J., additional, Jensen, Eric L. N., additional, Bignamini, Andrea, additional, Boschin, Walter, additional, Bouma, Luke G., additional, Ciardi, David R., additional, Cosentino, Rosario, additional, Desidera, Silvano, additional, Dumusque, Xavier, additional, Fiorenzano, Aldo F. M., additional, Fukui, Akihiko, additional, Giacobbe, Paolo, additional, Gnilka, Crystal L., additional, Ghedina, Adriano, additional, Guilluy, Gloria, additional, Harutyunyan, Avet, additional, Howell, Steve B., additional, Jenkins, Jon M., additional, Lund, Michael B., additional, Kielkopf, John F., additional, Lester, Katie V., additional, Malavolta, Luca, additional, Mann, Andrew W., additional, Matson, Rachel A., additional, Matthews, Elisabeth C., additional, Nardiello, Domenico, additional, Narita, Norio, additional, Pace, Emanuele, additional, Pagano, Isabella, additional, Palle, Enric, additional, Pedani, Marco, additional, Seager, Sara, additional, Schlieder, Joshua E., additional, Schwarz, Richard P., additional, Shporer, Avi, additional, Twicken, Joseph D., additional, Winn, Joshua N., additional, Ziegler, Carl, additional, and Zingales, Tiziano, additional
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- 2023
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218. Photometry and astrometry with JWST – III. A NIRCam-Gaia DR3 analysis of the open cluster NGC 2506
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Nardiello, D, primary, Bedin, L R, additional, Griggio, M, additional, Salaris, M, additional, Scalco, M, additional, and Cassisi, S, additional
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- 2023
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219. The GAPS programme at TNG
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Rainer, M., primary, Desidera, S., additional, Borsa, F., additional, Barbato, D., additional, Biazzo, K., additional, Bonomo, A., additional, Gratton, R., additional, Messina, S., additional, Scandariato, G., additional, Affer, L., additional, Benatti, S., additional, Carleo, I., additional, Cabona, L., additional, Covino, E., additional, Lanza, A. F., additional, Ligi, R., additional, Maldonado, J., additional, Mancini, L., additional, Nardiello, D., additional, Sicilia, D., additional, Sozzetti, A., additional, Bignamini, A., additional, Cosentino, R., additional, Knapic, C., additional, Martínez Fiorenzano, A. F., additional, Molinari, E., additional, Pedani, M., additional, and Poretti, E., additional
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- 2023
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220. TOI-179: A young system with a transiting compact Neptune-mass planet and a low-mass companion in outer orbit
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Desidera, S., primary, Damasso, M., additional, Gratton, R., additional, Benatti, S., additional, Nardiello, D., additional, D’Orazi, V., additional, Lanza, A. F., additional, Locci, D., additional, Marzari, F., additional, Mesa, D., additional, Messina, S., additional, Pillitteri, I., additional, Sozzetti, A., additional, Girard, J., additional, Maggio, A., additional, Micela, G., additional, Malavolta, L., additional, Nascimbeni, V., additional, Pinamonti, M., additional, Squicciarini, V., additional, Alcalá, J., additional, Biazzo, K., additional, Bohn, A., additional, Bonavita, M., additional, Brooks, K., additional, Chauvin, G., additional, Covino, E., additional, Delorme, P., additional, Hagelberg, J., additional, Janson, M., additional, Lagrange, A.-M., additional, and Lazzoni, C., additional
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- 2023
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221. Experimental Evaluation of 3D Ultrasound Palmprint Recognition Techniques Based on Curvature Methods and Under Skin Principal Lines.
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Antonio Iula and Donatella Nardiello
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- 2016
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222. Combined use of peptide ion and normalized delta scores to evaluate milk authenticity by ion-trap based proteomics coupled with error tolerant searching
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Nardiello, Donatella, Natale, Anna, Palermo, Carmen, Quinto, Maurizio, and Centonze, Diego
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- 2017
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223. Nano-LC–MS/MS for the identification of proteins trapped in sorbent cartridges used for coupled plasma filtration-adsorption treatments of healthy pigs
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Nardiello, Donatella, Prattichizzo, Clelia, Rocchetti, Maria Teresa, Gesualdo, Loreto, and Centonze, Diego
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- 2017
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224. Overexpression of helper T cell type 2-related molecules in the skin of patients with eosinophilic dermatosis of hematologic malignancy
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Francesco De Logu, Pamela Nardiello, Romina Nassini, Emiliano Antiga, Roberto Maglie, Elena Del Bianco, Gianna Baroni, Elisa Pasqualini, Filippo Ugolini, Daniela Massi, and Sara Simi
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Chemokine CCL11 ,Pathology ,medicine.medical_specialty ,T cell ,Eosinophilic dermatosis ,Dermatology ,Th2 Cells ,Pemphigoid, Bullous ,medicine ,Humans ,Interleukin 4 ,Retrospective Studies ,Cluster of differentiation ,business.industry ,Interleukins ,Forkhead Transcription Factors ,T-Lymphocytes, Helper-Inducer ,medicine.disease ,medicine.anatomical_structure ,Interleukin 31 ,Hematologic Neoplasms ,Interleukin-4 ,Bullous pemphigoid ,CD5 ,business ,CD8 - Abstract
Background Eosinophilic dermatosis of hematologic malignancy (EDHM) is a rare dermatosis associated with blood tumors. Objective To characterize the expression of T-cell and B-cell markers and pruritogenic mediators in EDHM skin. Methods Immunohistochemical and immunofluorescence analysis were performed in 12 skin samples of EDHM, 11 samples of bullous pemphigoid (BP), and 5 samples from healthy controls (HC). Serum levels of interleukin (IL) 4 were analyzed in 11 patients with EDHM, 11 BP patients, and 5 HC by enzyme-linked immunosorbent assay. Results T-cell markers, including clusters of differentiation (CD) 3, CD4, CD8, and CD5 were significantly overexpressed in EDHM and BP skin compared to HC. A predominance of CD4+ over CD8+ cells and GATA3+ (helper T cell type 2 [Th2] marker) over T-bet+ (Th1 marker) cells were observed. FOXP3 expression was increased but the FOXP3/CD4 ratio was low. B-cell markers were under-represented, without significant differences between the 3 groups. IL-4 and IL-31 were significantly overexpressed in EDHM and BP compared to HC and colocalized with the Th2-associated marker GATA3. Eotaxin-1 was significantly overexpressed in EDHM compared to BP and HC. IL-4 serum concentration was significantly increased in EDHM and BP compared to HC. Limitations Small sample size; retrospective design. Conclusions Targeting Th2-related molecules, in particular IL-4, holds promise for EDHM management.
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- 2022
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225. Hydroxylated Fatty Acids: The Role of the Sphingomyelin Synthase and the Origin of Selectivity
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Lucia Sessa, Anna Maria Nardiello, Jacopo Santoro, Simona Concilio, and Stefano Piotto
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SMS ,2—hydroxy oleic acid ,metadynamics ,Chemical technology ,TP1-1185 ,Chemical engineering ,TP155-156 - Abstract
Sphingolipids are a class of lipids acting as key modulators of many physiological and pathophysiological processes. Hydroxylation patterns have a major influence on the biophysical properties of sphingolipids. In this work, we have studied the mechanism of action of hydroxylated lipids in sphingomyelin synthase (SMS). The structures of the two human isoforms, SMS1 and SMS2, have been generated through neural network supported homology. Furthermore, we have elucidated the reaction mechanism that allows SMS to recover the choline head from a phosphocholine (PC) and transfer it to ceramide, and we have clarified the role of the hydroxyl group in the interaction with the enzyme. Finally, the effect of partial inhibition of SMS on the levels of PC and sphingomyelin was calculated for different rate constants solving ordinary differential equation systems.
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- 2021
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226. Turning Point USA Stands For Everything Loyola Shouldn't - The Greyhound
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Nardiello, Andrew
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News, opinion and commentary ,Sports and fitness - Abstract
Byline: Andrew Nardiello content'class='sno-story-body-content sno-no-cap'> Andrew Nardiello The following represents the opinion of the student reporter and does not represent the views of Loyola University Maryland, the Greyhound, or Loyola [...]
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- 2023
227. Prevalence and features of delirium in older patients admitted to rehabilitation facilities: a multicenter study
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Sidoli, C, Zambon, A, Tassistro, E, Rossi, E, Mossello, E, Inzitari, M, Cherubini, A, Marengoni, A, Morandi, A, Bellelli, G, Tarasconi, A, Sella, M, Paterno, G, Faggian, G, Lucarelli, C, De Grazia, N, Alberto, C, Porcella, L, Nardiello, I, Chimenti, E, Zeni, M, Romairone, E, Minaglia, C, Ceccotti, C, Guerra, G, Mantovani, G, Monacelli, F, Candiani, T, Santolini, F, Rosso, M, Bono, V, Sibilla, S, Dal Santo, P, Ceci, M, Barone, P, Schirinzi, T, Formenti, A, Nastasi, G, Isaia, G, Gonella, D, Battuello, A, Casson, S, Calvani, D, Boni, F, Ciaccio, A, Rosa, R, Sanna, G, Manfredini, S, Cortese, L, Rizzo, M, Prestano, R, Greco, A, Lauriola, M, Gelosa, G, Piras, V, Arena, M, Cosenza, D, Bellomo, A, Lamontagna, M, Gabbani, L, Lambertucci, L, Perego, S, Parati, G, Basile, G, Gallina, V, Pilone, G, Giudice, C, Pietrogrande, L, Mosca, M, Corazzin, I, Rossi, P, Nunziata, V, D'Amico, F, Grippa, A, Giardini, S, Barucci, R, Cossu, A, Fiorin, L, Distefano, M, Lunardelli, M, Brunori, M, Ruffini, I, Abraham, E, Varutti, A, Fabbro, E, Catalano, A, Martino, G, Leotta, D, Marchet, A, Dell'Aquila, G, Scrimieri, A, Davoli, M, Casella, M, Cartei, A, Polidori, G, Brischetto, D, Motta, S, Saponara, R, Perrone, P, Russo, G, Del, D, Car, C, Pirina, T, Franzoni, S, Cotroneo, A, Ghiggia, F, Volpi, G, Menichetti, C, Bo, M, Panico, A, Calogero, P, Corvalli, G, Mauri, M, Lupia, E, Manfredini, R, Fabbian, F, March, A, Pedrotti, M, Veronesi, M, Strocchi, E, Borghi, C, Bianchetti, A, Crucitti, A, Difrancesco, V, Fontana, G, Geriatria, A, Bonanni, L, Barbone, F, Serrati, C, Ballardini, G, Simoncelli, M, Ceschia, G, Scarpa, C, Brugiolo, R, Fusco, S, Ciarambino, T, Biagini, C, Tonon, E, Porta, M, Venuti, D, Delsette, M, Poeta, M, Barbagallo, G, Trovato, G, Delitala, A, Arosio, P, Reggiani, F, Zuliani, G, Ortolani, B, Mussio, E, Girardi, A, Coin, A, Ruotolo, G, Castagna, A, Masina, M, Cimino, R, Pinciaroli, A, Tripodi, G, Cassadonte, F, Vatrano, M, Scaglione, L, Fogliacco, P, Muzzuilini, C, Romano, F, Padovani, A, Rozzini, L, Cagnin, A, Fragiacomo, F, Desideri, G, Liberatore, E, Bruni, A, Orsitto, G, Franco, M, Bonfrate, L, Bonetto, M, Pizio, N, Magnani, G, Cecchetti, G, Longo, A, Bubba, V, Marinan, L, Cotelli, M, Turla, M, Sessa, M, Abruzzi, L, Castoldi, G, Lovetere, D, Musacchio, C, Novello, M, Cavarape, A, Bini, A, Leonardi, A, Seneci, F, Grimaldi, W, Fimognari, F, Bambar, V, Saitta, A, Corica, F, Braga, M, Servi, Ettorre, E, Camellini Bellelli, C, Annoni, G, Crescenzo, A, Noro, G, Turco, R, Ponzetto, M, Giuseppe, L, Mazzei, B, Maiuri, G, Costaggiu, D, Damato, R, Formilan, M, Patrizia, G, Santuar, L, Gallucci, M, Paragona, M, Bini, P, Modica, D, Abati, C, Clerici, M, Barbera, I, Nigroimperiale, F, Manni, A, Votino, C, Castiglioni, C, Di, M, Degl'Innocenti, M, Moscatelli, G, Guerini, S, Casini, C, Dini, D, Denotariis, S, Bonometti, F, Paolillo, C, Riccardi, A, Tiozzo, A, Samysalamafahmy, A, Dibari, M, Vanni, S, Scarpa, A, Zara, D, Ranieri, P, Alessandro, M, Di, F, Pezzoni, D, Platto, C, D'Ambrosio, V, Ivaldi, C, Milia, P, Desalvo, F, Solaro, C, Strazzacappa, M, Cazzadori, M, Grasso, M, Troisi, E, Guerini, V, Bernardini, B, Corsini, C, Boffelli, S, Filippi, A, Delpin, K, Faraci, B, Bertoletti, E, Vannucci, M, Crippa, P, Malighetti, A, Caltagirone, C, Disant, S, Bettini, D, Maltese, F, Abruzzese, G, Cosimo, D, Azzini, M, Colombo, M, Procino, G, Fascendini, S, Barocco, F, Del, P, Mazzone, A, Cottino, M, Vezzadini, G, Avanzi, S, Brambilla, C, Orini, S, Sgrilli, F, Mello, A, Lombardi Muti, L, Dijk, B, Fenu, S, Pes, C, Gareri, P, Passamonte, M, Rigo, R, Locusta, L, Caser, L, Rosso, G, Cesarini, S, Cozzi, R, Santini, C, Carbone, P, Cazzaniga, I, Lovati, R, Cantoni, A, Ranzani, P, Barra, D, Pompilio, G, Dimori, S, Cernesi, S, Ricco, C, Piazzolla, F, Capittini, E, Rota, C, Gottardi, F, Merla, L, Barelli, A, Millul, A, De, G, Morrone, G, Bigolari, M, Macchi, M, Zambon, F, Pizzorni, C, Dicasaleto, G, Menculini, G, Marcacci, M, Catanese, G, Sprini, D, Dicasalet, T, Bocci, M, Borga, S, Caironi, P, Cat, C, Cingolani, E, Avalli, L, Greco, G, Citerio, G, Gandini, L, Cornara, G, Lerda, R, Brazzi, L, Simeone, F, Caciorgna, M, Alampi, D, Francesconi, S, Beck, E, Antonini, B, Vettoretto, K, Meggiolaro, M, Garofalo, E, Notaro, S, Varutti, R, Bassi, F, Mistraletti, G, Marino, A, Rona, R, Rondelli, E, Riva, I, Cortegiani, A, Pistidda, L, D'Andrea, R, Querci, L, Gnesin, P, Todeschini, M, Lugano, M, Castelli, G, Ortolani, M, Cotoia, A, Maggiore, S, Ditizio, L, Graziani, R, Testa, I, Ferretti, E, Castioni, C, Lombardi, F, Caserta, R, Pasqua, M, Simoncini, S, Baccarini, F, Rispoli, M, Grossi, F, Cancelliere, L, Carnelli, M, Puccini, F, Biancofiore, G, Siniscalchi, A, Laici, C, Torrini, M, Pasetti, G, Palmese, S, Oggioni, R, Mangani, V, Pini, S, Martelli, M, Rigo, E, Zuccala, F, Cherri, A, Spina, R, Calamai, I, Petrucci, N, Caicedo, A, Ferri, F, Gritti, P, Brienza, N, Fonnesu, R, Dessena, M, Fullin, G, Saggioro, D, Sidoli C., Zambon A., Tassistro E., Rossi E., Mossello E., Inzitari M., Cherubini A., Marengoni A., Morandi A., Bellelli G., Tarasconi A., Sella M., Paterno G., Faggian G., Lucarelli C., De Grazia N., Alberto C., Porcella L., Nardiello I., Chimenti E., Zeni M., Romairone E., Minaglia C., Ceccotti C., Guerra G., Mantovani G., Monacelli F., Candiani T., Santolini F., Rosso M., Bono V., Sibilla S., Dal Santo P., Ceci M., Barone P., Schirinzi T., Formenti A., Nastasi G., Isaia G., Gonella D., Battuello A., Casson S., Calvani D., Boni F., Ciaccio A., Rosa R., Sanna G., Manfredini S., Cortese L., Rizzo M., Prestano R., Greco A., Lauriola M., Gelosa G., Piras V., Arena M., Cosenza D., Bellomo A., LaMontagna M., Gabbani L., Lambertucci L., Perego S., Parati G., Basile G., Gallina V., Pilone G., Giudice C., Pietrogrande L., Mosca M., Corazzin I., Rossi P., Nunziata V., D'Amico F., Grippa A., Giardini S., Barucci R., Cossu A., Fiorin L., Distefano M., Lunardelli M., Brunori M., Ruffini I., Abraham E., Varutti A., Fabbro E., Catalano A., Martino G., Leotta D., Marchet A., Dell'Aquila G., Scrimieri A., Davoli M., Casella M., Cartei A., Polidori G., Brischetto D., Motta S., Saponara R., Perrone P., Russo G., Del D., Car C., Pirina T., Franzoni S., Cotroneo A., Ghiggia F., Volpi G., Menichetti C., Bo M., Panico A., Calogero P., Corvalli G., Mauri M., Lupia E., Manfredini R., Fabbian F., March A., Pedrotti M., Veronesi M., Strocchi E., Borghi C., Bianchetti A., Crucitti A., DiFrancesco V., Fontana G., Geriatria A., Bonanni L., Barbone F., Serrati C., Ballardini G., Simoncelli M., Ceschia G., Scarpa C., Brugiolo R., Fusco S., Ciarambino T., Biagini C., Tonon E., Porta M., Venuti D., DelSette M., Poeta M., Barbagallo G., Trovato G., Delitala A., Arosio P., Reggiani F., Zuliani G., Ortolani B., Mussio E., Girardi A., Coin A., Ruotolo G., Castagna A., Masina M., Cimino R., Pinciaroli A., Tripodi G., Cassadonte F., Vatrano M., Scaglione L., Fogliacco P., Muzzuilini C., Romano F., Padovani A., Rozzini L., Cagnin A., Fragiacomo F., Desideri G., Liberatore E., Bruni A., Orsitto G., Franco M., Bonfrate L., Bonetto M., Pizio N., Magnani G., Cecchetti G., Longo A., Bubba V., Marinan L., Cotelli M., Turla M., Sessa M., Abruzzi L., Castoldi G., LoVetere D., Musacchio C., Novello M., Cavarape A., Bini A., Leonardi A., Seneci F., Grimaldi W., Fimognari F., Bambar V., Saitta A., Corica F., Braga M., Ettorre E., Camellini Bellelli C. G., Annoni G., Crescenzo A., Noro G., Turco R., Ponzetto M., Giuseppe L., Mazzei B., Maiuri G., Costaggiu D., Damato R., Formilan M., Patrizia G., Santuar L., Gallucci M., Paragona M., Bini P., Modica D., Abati C., Clerici M., Barbera I., NigroImperiale F., Manni A., Votino C., Castiglioni C., Di M., Degl'Innocenti M., Moscatelli G., Guerini S., Casini C., Dini D., DeNotariis S., Bonometti F., Paolillo C., Riccardi A., Tiozzo A., SamySalamaFahmy A., DiBari M., Vanni S., Scarpa A., Zara D., Ranieri P., Alessandro M., Di F., Pezzoni D., Platto C., D'Ambrosio V., Ivaldi C., Milia P., DeSalvo F., Solaro C., Strazzacappa M., Cazzadori M., Grasso M., Troisi E., Guerini V., Bernardini B., Corsini C., Boffelli S., Filippi A., Delpin K., Faraci B., Bertoletti E., Vannucci M., Crippa P., Malighetti A., Caltagirone C., DiSant S., Bettini D., Maltese F., Abruzzese G., Cosimo D., Azzini M., Colombo M., Procino G., Fascendini S., Barocco F., Del P., Mazzone A., Cottino M., Vezzadini G., Avanzi S., Brambilla C., Orini S., Sgrilli F., Mello A., Lombardi Muti L. E., Dijk B., Fenu S., Pes C., Gareri P., Passamonte M., Rigo R., Locusta L., Caser L., Rosso G., Cesarini S., Cozzi R., Santini C., Carbone P., Cazzaniga I., Lovati R., Cantoni A., Ranzani P., Barra D., Pompilio G., Dimori S., Cernesi S., Ricco C., Piazzolla F., Capittini E., Rota C., Gottardi F., Merla L., Barelli A., Millul A., De G., Morrone G., Bigolari M., Macchi M., Zambon F., Pizzorni C., DiCasaleto G., Menculini G., Marcacci M., Catanese G., Sprini D., DiCasalet T., Bocci M., Borga S., Caironi P., Cat C., Cingolani E., Avalli L., Greco G., Citerio G., Gandini L., Cornara G., Lerda R., Brazzi L., Simeone F., Caciorgna M., Alampi D., Francesconi S., Beck E., Antonini B., Vettoretto K., Meggiolaro M., Garofalo E., Notaro S., Varutti R., Bassi F., Mistraletti G., Marino A., Rona R., Rondelli E., Riva I., Cortegiani A., Pistidda L., D'Andrea R., Querci L., Gnesin P., Todeschini M., Lugano M., Castelli G., Ortolani M., Cotoia A., Maggiore S., DiTizio L., Graziani R., Testa I., Ferretti E., Castioni C., Lombardi F., Caserta R., Pasqua M., Simoncini S., Baccarini F., Rispoli M., Grossi F., Cancelliere L., Carnelli M., Puccini F., Biancofiore G., Siniscalchi A., Laici C., Torrini M., Pasetti G., Palmese S., Oggioni R., Mangani V., Pini S., Martelli M., Rigo E., Zuccala F., Cherri A., Spina R., Calamai I., Petrucci N., Caicedo A., Ferri F., Gritti P., Brienza N., Fonnesu R., Dessena M., Fullin G., Saggioro D., Sidoli, C, Zambon, A, Tassistro, E, Rossi, E, Mossello, E, Inzitari, M, Cherubini, A, Marengoni, A, Morandi, A, Bellelli, G, Tarasconi, A, Sella, M, Paterno, G, Faggian, G, Lucarelli, C, De Grazia, N, Alberto, C, Porcella, L, Nardiello, I, Chimenti, E, Zeni, M, Romairone, E, Minaglia, C, Ceccotti, C, Guerra, G, Mantovani, G, Monacelli, F, Candiani, T, Santolini, F, Rosso, M, Bono, V, Sibilla, S, Dal Santo, P, Ceci, M, Barone, P, Schirinzi, T, Formenti, A, Nastasi, G, Isaia, G, Gonella, D, Battuello, A, Casson, S, Calvani, D, Boni, F, Ciaccio, A, Rosa, R, Sanna, G, Manfredini, S, Cortese, L, Rizzo, M, Prestano, R, Greco, A, Lauriola, M, Gelosa, G, Piras, V, Arena, M, Cosenza, D, Bellomo, A, Lamontagna, M, Gabbani, L, Lambertucci, L, Perego, S, Parati, G, Basile, G, Gallina, V, Pilone, G, Giudice, C, Pietrogrande, L, Mosca, M, Corazzin, I, Rossi, P, Nunziata, V, D'Amico, F, Grippa, A, Giardini, S, Barucci, R, Cossu, A, Fiorin, L, Distefano, M, Lunardelli, M, Brunori, M, Ruffini, I, Abraham, E, Varutti, A, Fabbro, E, Catalano, A, Martino, G, Leotta, D, Marchet, A, Dell'Aquila, G, Scrimieri, A, Davoli, M, Casella, M, Cartei, A, Polidori, G, Brischetto, D, Motta, S, Saponara, R, Perrone, P, Russo, G, Del, D, Car, C, Pirina, T, Franzoni, S, Cotroneo, A, Ghiggia, F, Volpi, G, Menichetti, C, Bo, M, Panico, A, Calogero, P, Corvalli, G, Mauri, M, Lupia, E, Manfredini, R, Fabbian, F, March, A, Pedrotti, M, Veronesi, M, Strocchi, E, Borghi, C, Bianchetti, A, Crucitti, A, Difrancesco, V, Fontana, G, Geriatria, A, Bonanni, L, Barbone, F, Serrati, C, Ballardini, G, Simoncelli, M, Ceschia, G, Scarpa, C, Brugiolo, R, Fusco, S, Ciarambino, T, Biagini, C, Tonon, E, Porta, M, Venuti, D, Delsette, M, Poeta, M, Barbagallo, G, Trovato, G, Delitala, A, Arosio, P, Reggiani, F, Zuliani, G, Ortolani, B, Mussio, E, Girardi, A, Coin, A, Ruotolo, G, Castagna, A, Masina, M, Cimino, R, Pinciaroli, A, Tripodi, G, Cassadonte, F, Vatrano, M, Scaglione, L, Fogliacco, P, Muzzuilini, C, Romano, F, Padovani, A, Rozzini, L, Cagnin, A, Fragiacomo, F, Desideri, G, Liberatore, E, Bruni, A, Orsitto, G, Franco, M, Bonfrate, L, Bonetto, M, Pizio, N, Magnani, G, Cecchetti, G, Longo, A, Bubba, V, Marinan, L, Cotelli, M, Turla, M, Sessa, M, Abruzzi, L, Castoldi, G, Lovetere, D, Musacchio, C, Novello, M, Cavarape, A, Bini, A, Leonardi, A, Seneci, F, Grimaldi, W, Fimognari, F, Bambar, V, Saitta, A, Corica, F, Braga, M, Servi, Ettorre, E, Camellini Bellelli, C, Annoni, G, Crescenzo, A, Noro, G, Turco, R, Ponzetto, M, Giuseppe, L, Mazzei, B, Maiuri, G, Costaggiu, D, Damato, R, Formilan, M, Patrizia, G, Santuar, L, Gallucci, M, Paragona, M, Bini, P, Modica, D, Abati, C, Clerici, M, Barbera, I, Nigroimperiale, F, Manni, A, Votino, C, Castiglioni, C, Di, M, Degl'Innocenti, M, Moscatelli, G, Guerini, S, Casini, C, Dini, D, Denotariis, S, Bonometti, F, Paolillo, C, Riccardi, A, Tiozzo, A, Samysalamafahmy, A, Dibari, M, Vanni, S, Scarpa, A, Zara, D, Ranieri, P, Alessandro, M, Di, F, Pezzoni, D, Platto, C, D'Ambrosio, V, Ivaldi, C, Milia, P, Desalvo, F, Solaro, C, Strazzacappa, M, Cazzadori, M, Grasso, M, Troisi, E, Guerini, V, Bernardini, B, Corsini, C, Boffelli, S, Filippi, A, Delpin, K, Faraci, B, Bertoletti, E, Vannucci, M, Crippa, P, Malighetti, A, Caltagirone, C, Disant, S, Bettini, D, Maltese, F, Abruzzese, G, Cosimo, D, Azzini, M, Colombo, M, Procino, G, Fascendini, S, Barocco, F, Del, P, Mazzone, A, Cottino, M, Vezzadini, G, Avanzi, S, Brambilla, C, Orini, S, Sgrilli, F, Mello, A, Lombardi Muti, L, Dijk, B, Fenu, S, Pes, C, Gareri, P, Passamonte, M, Rigo, R, Locusta, L, Caser, L, Rosso, G, Cesarini, S, Cozzi, R, Santini, C, Carbone, P, Cazzaniga, I, Lovati, R, Cantoni, A, Ranzani, P, Barra, D, Pompilio, G, Dimori, S, Cernesi, S, Ricco, C, Piazzolla, F, Capittini, E, Rota, C, Gottardi, F, Merla, L, Barelli, A, Millul, A, De, G, Morrone, G, Bigolari, M, Macchi, M, Zambon, F, Pizzorni, C, Dicasaleto, G, Menculini, G, Marcacci, M, Catanese, G, Sprini, D, Dicasalet, T, Bocci, M, Borga, S, Caironi, P, Cat, C, Cingolani, E, Avalli, L, Greco, G, Citerio, G, Gandini, L, Cornara, G, Lerda, R, Brazzi, L, Simeone, F, Caciorgna, M, Alampi, D, Francesconi, S, Beck, E, Antonini, B, Vettoretto, K, Meggiolaro, M, Garofalo, E, Notaro, S, Varutti, R, Bassi, F, Mistraletti, G, Marino, A, Rona, R, Rondelli, E, Riva, I, Cortegiani, A, Pistidda, L, D'Andrea, R, Querci, L, Gnesin, P, Todeschini, M, Lugano, M, Castelli, G, Ortolani, M, Cotoia, A, Maggiore, S, Ditizio, L, Graziani, R, Testa, I, Ferretti, E, Castioni, C, Lombardi, F, Caserta, R, Pasqua, M, Simoncini, S, Baccarini, F, Rispoli, M, Grossi, F, Cancelliere, L, Carnelli, M, Puccini, F, Biancofiore, G, Siniscalchi, A, Laici, C, Torrini, M, Pasetti, G, Palmese, S, Oggioni, R, Mangani, V, Pini, S, Martelli, M, Rigo, E, Zuccala, F, Cherri, A, Spina, R, Calamai, I, Petrucci, N, Caicedo, A, Ferri, F, Gritti, P, Brienza, N, Fonnesu, R, Dessena, M, Fullin, G, Saggioro, D, Sidoli C., Zambon A., Tassistro E., Rossi E., Mossello E., Inzitari M., Cherubini A., Marengoni A., Morandi A., Bellelli G., Tarasconi A., Sella M., Paterno G., Faggian G., Lucarelli C., De Grazia N., Alberto C., Porcella L., Nardiello I., Chimenti E., Zeni M., Romairone E., Minaglia C., Ceccotti C., Guerra G., Mantovani G., Monacelli F., Candiani T., Santolini F., Rosso M., Bono V., Sibilla S., Dal Santo P., Ceci M., Barone P., Schirinzi T., Formenti A., Nastasi G., Isaia G., Gonella D., Battuello A., Casson S., Calvani D., Boni F., Ciaccio A., Rosa R., Sanna G., Manfredini S., Cortese L., Rizzo M., Prestano R., Greco A., Lauriola M., Gelosa G., Piras V., Arena M., Cosenza D., Bellomo A., LaMontagna M., Gabbani L., Lambertucci L., Perego S., Parati G., Basile G., Gallina V., Pilone G., Giudice C., Pietrogrande L., Mosca M., Corazzin I., Rossi P., Nunziata V., D'Amico F., Grippa A., Giardini S., Barucci R., Cossu A., Fiorin L., Distefano M., Lunardelli M., Brunori M., Ruffini I., Abraham E., Varutti A., Fabbro E., Catalano A., Martino G., Leotta D., Marchet A., Dell'Aquila G., Scrimieri A., Davoli M., Casella M., Cartei A., Polidori G., Brischetto D., Motta S., Saponara R., Perrone P., Russo G., Del D., Car C., Pirina T., Franzoni S., Cotroneo A., Ghiggia F., Volpi G., Menichetti C., Bo M., Panico A., Calogero P., Corvalli G., Mauri M., Lupia E., Manfredini R., Fabbian F., March A., Pedrotti M., Veronesi M., Strocchi E., Borghi C., Bianchetti A., Crucitti A., DiFrancesco V., Fontana G., Geriatria A., Bonanni L., Barbone F., Serrati C., Ballardini G., Simoncelli M., Ceschia G., Scarpa C., Brugiolo R., Fusco S., Ciarambino T., Biagini C., Tonon E., Porta M., Venuti D., DelSette M., Poeta M., Barbagallo G., Trovato G., Delitala A., Arosio P., Reggiani F., Zuliani G., Ortolani B., Mussio E., Girardi A., Coin A., Ruotolo G., Castagna A., Masina M., Cimino R., Pinciaroli A., Tripodi G., Cassadonte F., Vatrano M., Scaglione L., Fogliacco P., Muzzuilini C., Romano F., Padovani A., Rozzini L., Cagnin A., Fragiacomo F., Desideri G., Liberatore E., Bruni A., Orsitto G., Franco M., Bonfrate L., Bonetto M., Pizio N., Magnani G., Cecchetti G., Longo A., Bubba V., Marinan L., Cotelli M., Turla M., Sessa M., Abruzzi L., Castoldi G., LoVetere D., Musacchio C., Novello M., Cavarape A., Bini A., Leonardi A., Seneci F., Grimaldi W., Fimognari F., Bambar V., Saitta A., Corica F., Braga M., Ettorre E., Camellini Bellelli C. G., Annoni G., Crescenzo A., Noro G., Turco R., Ponzetto M., Giuseppe L., Mazzei B., Maiuri G., Costaggiu D., Damato R., Formilan M., Patrizia G., Santuar L., Gallucci M., Paragona M., Bini P., Modica D., Abati C., Clerici M., Barbera I., NigroImperiale F., Manni A., Votino C., Castiglioni C., Di M., Degl'Innocenti M., Moscatelli G., Guerini S., Casini C., Dini D., DeNotariis S., Bonometti F., Paolillo C., Riccardi A., Tiozzo A., SamySalamaFahmy A., DiBari M., Vanni S., Scarpa A., Zara D., Ranieri P., Alessandro M., Di F., Pezzoni D., Platto C., D'Ambrosio V., Ivaldi C., Milia P., DeSalvo F., Solaro C., Strazzacappa M., Cazzadori M., Grasso M., Troisi E., Guerini V., Bernardini B., Corsini C., Boffelli S., Filippi A., Delpin K., Faraci B., Bertoletti E., Vannucci M., Crippa P., Malighetti A., Caltagirone C., DiSant S., Bettini D., Maltese F., Abruzzese G., Cosimo D., Azzini M., Colombo M., Procino G., Fascendini S., Barocco F., Del P., Mazzone A., Cottino M., Vezzadini G., Avanzi S., Brambilla C., Orini S., Sgrilli F., Mello A., Lombardi Muti L. E., Dijk B., Fenu S., Pes C., Gareri P., Passamonte M., Rigo R., Locusta L., Caser L., Rosso G., Cesarini S., Cozzi R., Santini C., Carbone P., Cazzaniga I., Lovati R., Cantoni A., Ranzani P., Barra D., Pompilio G., Dimori S., Cernesi S., Ricco C., Piazzolla F., Capittini E., Rota C., Gottardi F., Merla L., Barelli A., Millul A., De G., Morrone G., Bigolari M., Macchi M., Zambon F., Pizzorni C., DiCasaleto G., Menculini G., Marcacci M., Catanese G., Sprini D., DiCasalet T., Bocci M., Borga S., Caironi P., Cat C., Cingolani E., Avalli L., Greco G., Citerio G., Gandini L., Cornara G., Lerda R., Brazzi L., Simeone F., Caciorgna M., Alampi D., Francesconi S., Beck E., Antonini B., Vettoretto K., Meggiolaro M., Garofalo E., Notaro S., Varutti R., Bassi F., Mistraletti G., Marino A., Rona R., Rondelli E., Riva I., Cortegiani A., Pistidda L., D'Andrea R., Querci L., Gnesin P., Todeschini M., Lugano M., Castelli G., Ortolani M., Cotoia A., Maggiore S., DiTizio L., Graziani R., Testa I., Ferretti E., Castioni C., Lombardi F., Caserta R., Pasqua M., Simoncini S., Baccarini F., Rispoli M., Grossi F., Cancelliere L., Carnelli M., Puccini F., Biancofiore G., Siniscalchi A., Laici C., Torrini M., Pasetti G., Palmese S., Oggioni R., Mangani V., Pini S., Martelli M., Rigo E., Zuccala F., Cherri A., Spina R., Calamai I., Petrucci N., Caicedo A., Ferri F., Gritti P., Brienza N., Fonnesu R., Dessena M., Fullin G., and Saggioro D.
- Abstract
Background: Delirium is thought to be common across various settings of care; however, still little research has been conducted in rehabilitation. Aim: We investigated the prevalence of delirium, its features and motor subtypes in older patients admitted to rehabilitation facilities during the three editions of the “Delirium Day project”. Methods: We conducted a cross-sectional study in which 1237 older patients (age ≥ 65 years old) admitted to 50 Italian rehabilitation wards during the three editions of the “Delirium Day project” (2015 to 2017) were included. Delirium was evaluated through the 4AT and its motor subtype with the Delirium Motor Subtype Scale. Results: Delirium was detected in 226 patients (18%), and the most recurrent motor subtype was mixed (37%), followed by hypoactive (26%), hyperactive (21%) and non-motor one (16%). In a multivariate Poisson regression model with robust variance, factors associated with delirium were: disability in basic (PR 1.48, 95%CI: 1.17–1.9, p value 0.001) and instrumental activities of daily living (PR 1.58, 95%CI: 1.08–2.32, p value 0.018), dementia (PR 2.10, 95%CI: 1.62–2.73, p value < 0.0001), typical antipsychotics (PR 1.47, 95%CI: 1.10–1.95, p value 0.008), antidepressants other than selective serotonin reuptake inhibitors (PR 1.3, 95%CI: 1.02–1.66, p value 0.035), and physical restraints (PR 2.37, 95%CI: 1.68–3.36, p value < 0.0001). Conclusion: This multicenter study reports that 2 out 10 patients admitted to rehabilitations had delirium on the index day. Mixed delirium was the most prevalent subtype. Delirium was associated with unmodifiable (dementia, disability) and modifiable (physical restraints, medications) factors. Identification of these factors should prompt specific interventions aimed to prevent or mitigate delirium.
- Published
- 2022
228. Hermetia illucens (L.) (Diptera: Stratiomyidae) Odorant Binding Proteins and Their Interactions with Selected Volatile Organic Compounds: An In Silico Approach
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Carmen Scieuzo, Marisa Nardiello, Donatella Farina, Andrea Scala, Jonathan A. Cammack, Jeffery K. Tomberlin, Heiko Vogel, Rosanna Salvia, Krishna Persaud, and Patrizia Falabella
- Subjects
black soldier fly ,next generation sequencing ,expression analysis ,VOCs ,OBPs ,molecular docking ,Science - Abstract
The black soldier fly (BSF), Hermetia illucens (Diptera: Stratiomyidae), has considerable global interest due to its outstanding capacity in bioconverting organic waste to insect biomass, which can be used for livestock, poultry, and aquaculture feed. Mass production of this insect in colonies requires the development of methods concentrating oviposition in specific collection devices, while the mass production of larvae and disposing of waste may require substrates that are more palatable and more attractive to the insects. In insects, chemoreception plays an essential role throughout their life cycle, responding to an array of chemical, biological and environmental signals to locate and select food, mates, oviposition sites and avoid predators. To interpret these signals, insects use an arsenal of molecular components, including small proteins called odorant binding proteins (OBPs). Next generation sequencing was used to identify genes involved in chemoreception during the larval and adult stage of BSF, with particular attention to OBPs. The analysis of the de novo adult and larval transcriptome led to the identification of 27 and 31 OBPs for adults and larvae, respectively. Among these OBPs, 15 were common in larval and adult transcriptomes and the tertiary structures of 8 selected OBPs were modelled. In silico docking of ligands confirms the potential interaction with VOCs of interest. Starting from the information about the growth performance of H. illucens on different organic substrates from the agri-food sector, the present work demonstrates a possible correlation between a pool of selected VOCs, emitted by those substrates that are attractive for H. illucens females when searching for oviposition sites, as well as phagostimulants for larvae. The binding affinities between OBPs and selected ligands calculated by in silico modelling may indicate a correlation among OBPs, VOCs and behavioural preferences that will be the basis for further analysis.
- Published
- 2021
- Full Text
- View/download PDF
229. Solanum nigrum Extract and Solasonine Affected Hemolymph Metabolites and Ultrastructure of the Fat Body and the Midgut in Galleria mellonella
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Marta Spochacz, Szymon Chowański, Monika Szymczak-Cendlak, Paweł Marciniak, Filomena Lelario, Rosanna Salvia, Marisa Nardiello, Carmen Scieuzo, Laura Scrano, Sabino A. Bufo, Zbigniew Adamski, and Patrizia Falabella
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Galleria mellonella ,glycoalkaloids ,Solanum nigrum extract ,solasonine ,hemolymph ,polyols ,Medicine - Abstract
Glycoalkaloids, secondary metabolites abundant in plants belonging to the Solanaceae family, may affect the physiology of insect pests. This paper presents original results dealing with the influence of a crude extract obtained from Solanum nigrum unripe berries and its main constituent, solasonine, on the physiology of Galleria mellonella (Lepidoptera) that can be used as an alternative bioinsecticide. G. mellonella IV instar larvae were treated with S. nigrum extract and solasonine at different concentrations. The effects of extract and solasonine were evaluated analyzing changes in carbohydrate and amino acid composition in hemolymph by RP-HPLC and in the ultrastructure of the fat body cells by TEM. Both extract and solasonine changed the level of hemolymph metabolites and the ultrastructure of the fat body and the midgut cells. In particular, the extract increased the erythritol level in the hemolymph compared to control, enlarged the intracellular space in fat body cells, and decreased cytoplasm and lipid droplets electron density. The solasonine, tested with three concentrations, caused the decrease of cytoplasm electron density in both fat body and midgut cells. Obtained results highlighted the disturbance of the midgut and the fat body due to glycoalkaloids and the potential role of hemolymph ingredients in its detoxification. These findings suggest a possible application of glycoalkaloids as a natural insecticide in the pest control of G. mellonella larvae.
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- 2021
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230. Pesticides Contamination of Cereals and Legumes: Monitoring of Samples Marketed in Italy as a Contribution to Risk Assessment
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Valeria Nardelli, Valeria D’Amico, Mariateresa Ingegno, Ines Della Rovere, Marco Iammarino, Francesco Casamassima, Anna Calitri, Donatella Nardiello, Donghao Li, and Maurizio Quinto
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pesticides ,cereals ,legumes ,food safety ,food contamination ,gas-chromatography and mass spectrometry (GC-MS) ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The evaluation of cereal-based product contamination by pesticide residues is a topic of worldwide importance, and reliable analytical methods for official check analyses and monitoring studies are required for multi-residue analysis at trace levels. In this work, a validated multi-residual analytical method by gas-chromatography and tandem mass spectrometry coupled with a rapid QuEChERS procedure was used for the determination of 37 pesticides (pyrethroids, organophosphorus and organochlorine compounds) in 209 commercially available samples of cereals and 11 legumes, placed on the Italian market in 2018 and 2019, coming from different regions of Italy, eastern Europe, and some non-European countries. No pesticide traces were observed in the analyzed legume samples. A total of 18 cereal samples were found to be contaminated by at least one pesticide, with a concentration level higher than the corresponding quantification limit, but never exceeding the maximum level fixed in the European Regulations. This work is the first part of a surveillance study for pesticide control in food samples.
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- 2021
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231. Outliers: multicolour photometry guiding the search for evolved binary systems in the globular cluster 47 Tucanae
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Fabíola Campos, I Pelisoli, S Kamann, T-O Husser, S Dreizler, A Bellini, E L Robinson, D Nardiello, G Piotto, S O Kepler, A G Istrate, D E Winget, M H Montgomery, and A Dotter
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- 2018
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232. The Hubble Space Telescope UV legacy survey of galactic globular clusters – XVI. The helium abundance of multiple populations
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A P Milone, A F Marino, A Renzini, F D’Antona, J Anderson, B Barbuy, L R Bedin, A Bellini, T M Brown, S Cassisi, G Cordoni, E P Lagioia, D Nardiello, S Ortolani, G Piotto, A Sarajedini, M Tailo, R P van der Marel, and E Vesperini
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- 2018
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233. Standardisation of oxygen exposure in the development of mouse models for bronchopulmonary dysplasia
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Claudio Nardiello, Ivana Mižíková, Diogo M. Silva, Jordi Ruiz-Camp, Konstantin Mayer, István Vadász, Susanne Herold, Werner Seeger, and Rory E. Morty
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BPD ,Hyperoxia ,Alveolarisation ,Structure ,Animal model ,Medicine ,Pathology ,RB1-214 - Abstract
Progress in developing new therapies for bronchopulmonary dysplasia (BPD) is sometimes complicated by the lack of a standardised animal model. Our objective was to develop a robust hyperoxia-based mouse model of BPD that recapitulated the pathological perturbations to lung structure noted in infants with BPD. Newborn mouse pups were exposed to a varying fraction of oxygen in the inspired air (FiO2) and a varying window of hyperoxia exposure, after which lung structure was assessed by design-based stereology with systemic uniform random sampling. The efficacy of a candidate therapeutic intervention using parenteral nutrition was evaluated to demonstrate the utility of the standardised BPD model for drug discovery. An FiO2 of 0.85 for the first 14 days of life decreased total alveoli number and concomitantly increased alveolar septal wall thickness, which are two key histopathological characteristics of BPD. A reduction in FiO2 to 0.60 or 0.40 also caused a decrease in the total alveoli number, but the septal wall thickness was not impacted. Neither a decreasing oxygen gradient (from FiO2 0.85 to 0.21 over the first 14 days of life) nor an oscillation in FiO2 (between 0.85 and 0.40 on a 24 h:24 h cycle) had an appreciable impact on lung development. The risk of missing beneficial effects of therapeutic interventions at FiO2 0.85, using parenteral nutrition as an intervention in the model, was also noted, highlighting the utility of lower FiO2 in selected studies, and underscoring the need to tailor the model employed to the experimental intervention. Thus, a state-of-the-art BPD animal model that recapitulates the two histopathological hallmark perturbations to lung architecture associated with BPD is described. The model presented here, where injurious stimuli have been systematically evaluated, provides a most promising approach for the development of new strategies to drive postnatal lung maturation in affected infants.
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- 2017
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234. The Action of VIRKON No Foam on the Hepatitis B Virus
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Scioli, D., Pizzella, T., Vollaro, L., Nardiello, S., and De Feo, L.
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- 1997
235. X-Ray and Ultraviolet Emission of the Young Planet-hosting Star V1298 Tau from Coordinated Observations with XMM-Newton and Hubble Space Telescope
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Maggio, A., primary, Pillitteri, I., additional, Argiroffi, C., additional, Benatti, S., additional, Sanz-Forcada, J., additional, D’Orazi, V., additional, Biazzo, K., additional, Borsa, F., additional, Cabona, L., additional, Claudi, R., additional, Desidera, S., additional, Locci, D., additional, Nardiello, D., additional, Mancini, L., additional, Micela, G., additional, Rainer, M., additional, Spinelli, R., additional, Bignamini, A., additional, and Damasso, M., additional
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- 2023
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236. Exploring the origin of the extended main-sequence turn-off in M37 through the white dwarf cooling sequence
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Griggio, M, primary, Salaris, M, additional, Nardiello, D, additional, Bedin, L R, additional, Cassisi, S, additional, and Anderson, J, additional
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- 2023
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237. The GAPS programme at TNG
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Maldonado, J., primary, Petralia, A., additional, Mantovan, G., additional, Rainer, M., additional, Lanza, A. F., additional, Di Maio, C., additional, Colombo, S., additional, Nardiello, D., additional, Benatti, S., additional, Borsato, L., additional, Carleo, I., additional, Desidera, S., additional, Micela, G., additional, Nascimbeni, V., additional, Malavolta, L., additional, Damasso, M., additional, Sozzetti, A., additional, Affer, L., additional, Biazzo, K., additional, Bignamini, A., additional, Bonomo, A. S., additional, Borsa, F., additional, Lund, M. B., additional, Mancini, L., additional, Molinari, E., additional, and Molinaro, M., additional
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- 2023
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238. Hyades Member K2-136c: The Smallest Planet in an Open Cluster with a Precisely Measured Mass
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Mayo, Andrew W., primary, Dressing, Courtney D., additional, Vanderburg, Andrew, additional, Fortenbach, Charles D., additional, Lienhard, Florian, additional, Malavolta, Luca, additional, Mortier, Annelies, additional, Núñez, Alejandro, additional, Richey-Yowell, Tyler, additional, Turtelboom, Emma V., additional, Bonomo, Aldo S., additional, Latham, David W., additional, López-Morales, Mercedes, additional, Shkolnik, Evgenya, additional, Sozzetti, Alessandro, additional, Agüeros, Marcel A., additional, Borsato, Luca, additional, Charbonneau, David, additional, Cosentino, Rosario, additional, Douglas, Stephanie T., additional, Dumusque, Xavier, additional, Ghedina, Adriano, additional, Gibson, Rose, additional, Granata, Valentina, additional, Harutyunyan, Avet, additional, Haywood, R. D., additional, Lacedelli, Gaia, additional, Lorenzi, Vania, additional, Magazzù, Antonio, additional, Martinez Fiorenzano, A. F., additional, Micela, Giuseppina, additional, Molinari, Emilio, additional, Montalto, Marco, additional, Nardiello, Domenico, additional, Nascimbeni, Valerio, additional, Pagano, Isabella, additional, Piotto, Giampaolo, additional, Pino, Lorenzo, additional, Poretti, Ennio, additional, Scandariato, Gaetano, additional, Udry, Stephane, additional, and Buchhave, Lars A., additional
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- 2023
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239. P54 RIGHT SINGLE CORONARY ARTERY AS AN INCIDENTAL FINDING IN ACUTE PERICARDIAL DISEASE
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Nunziata, L, primary, Terracciano, F, additional, Maresca, G, additional, Granata, F, additional, Falato, S, additional, Ambrosino, S, additional, Carbone, L, additional, Ruggiero, V, additional, Laezza, A, additional, Prisco, A, additional, Nardiello, V, additional, Miele, R, additional, Sena, L, additional, America, R, additional, Volpicelli, M, additional, Muto, C, additional, Capasso, M, additional, and Caliendo, L, additional
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- 2023
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240. The GAPS Programme at TNG
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Damasso, M., primary, Locci, D., additional, Benatti, S., additional, Maggio, A., additional, Nardiello, D., additional, Baratella, M., additional, Biazzo, K., additional, Bonomo, A. S., additional, Desidera, S., additional, D'Orazi, V., additional, Mallonn, M., additional, Lanza, A. F., additional, Sozzetti, A., additional, Marzari, F., additional, Borsa, F., additional, Maldonado, J., additional, Mancini, L., additional, Poretti, E., additional, Scandariato, G., additional, Bignamini, A., additional, Borsato, L., additional, Capuzzo Dolcetta, R., additional, Cecconi, M., additional, Claudi, R., additional, Cosentino, R., additional, Covino, E., additional, Fiorenzano, A., additional, Harutyunyan, A., additional, Mann, A. W., additional, Micela, G., additional, Molinari, E., additional, Molinaro, M., additional, Pagano, I., additional, Pedani, M., additional, Pinamonti, M., additional, Piotto, G., additional, and Stoev, H., additional
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- 2023
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241. Photometric follow-up of the 20 Myr old multi-planet host star V1298 Tau with CHEOPS and ground-based telescopes
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Damasso, M., Scandariato, G., Nascimbeni, V., Nardiello, D., Mancini, L., Marino, G., Bruno, G., Brandeker, Alexis, Leto, G., Marzari, F., Lanza, A. F., Benatti, S., Desidera, S., Béjar, V. J. S., Biagini, A., Borsato, L., Cabona, L., Claudi, R., Lodieu, N., Maggio, A., Mallorquín, M., Messina, S., Micela, G., Ricci, D., Sozzetti, A., Mascareño, A. Suárez, Turrini, D., Osorio, M. R. Zapatero, Damasso, M., Scandariato, G., Nascimbeni, V., Nardiello, D., Mancini, L., Marino, G., Bruno, G., Brandeker, Alexis, Leto, G., Marzari, F., Lanza, A. F., Benatti, S., Desidera, S., Béjar, V. J. S., Biagini, A., Borsato, L., Cabona, L., Claudi, R., Lodieu, N., Maggio, A., Mallorquín, M., Messina, S., Micela, G., Ricci, D., Sozzetti, A., Mascareño, A. Suárez, Turrini, D., and Osorio, M. R. Zapatero
- Abstract
Context. The 20 Myr old star V1298 Tau hosts at least four planets. Since its discovery, this system has been a target of intensive photometric and spectroscopic monitoring. To date, the characterisation of its architecture and planets’ fundamental properties has been very challenging. Aims. The determination of the orbital ephemeris of the outermost planet V1298 Tau e remains an open question. Only two transits have been detected so far by Kepler/K2 and TESS, allowing for a grid of reference periods to be tested with new observations, without excluding the possibility of transit timing variations. Observing a third transit would allow for better constraints to be set on the orbital period and would also help in determining an accurate radius for V1298 Tau e because the previous transits showed different depths. Methods. We observed V1298 Tau with the CHaracterising ExOPlanet Satellite (CHEOPS) to search for a third transit of planet e within observing windows selected to test three of the shortest predicted orbital periods. We also collected ground-based observations to verify the result found with CHEOPS. We reanalysed Kepler/K2 and TESS light curves to test how the results derived from these data are affected by alternative photometric extraction and detrending methods. Results. We report the CHEOPS detection of a transit-like signal that could be attributed to V1298 Tau e. If so, that result would imply that the orbital period calculated from fitting a linear ephemeris to the three available transits is close to ~45 days. Results from the ground-based follow-up marginally support this possibility. We found that i) the transit observed by CHEOPS has a longer duration compared to that of the transits observed by Kepler/K2 and TESS; and ii) the transit observed by TESS is >30% deeper than that of Kepler/K2 and CHEOPS, and it is also deeper than the measurement previously reported in the literature, according to our reanalysis. Conclusions. If the new transit det
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- 2023
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242. A large topographic feature on the surface of the trans-Neptunian object (307261) 2002 MS4 measured from stellar occultations
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Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Rommel, F.L., Braga-Ribas, F., Ortiz Moreno, José Luis, Sicardy, B., Santos Sanz, Pablo, Desmars, Josselin, Camargo, J.I.B., Vieira-Martins, R., Assafin, M., Morgado, B.E., Boufleur, R.C., Burwitz, V., Waldemar Sybilski, P., Bykowski, W., Müller, Thomas G., Ogloza, W., Gonçalves, R., Ferreira, J.F., Ferreira, M., Bento, M., Urbaník, M., Di Sora, M., Souami, Damya, Canales-Moreno, O., Meister, S., Bagiran, M.N., Tekeş, M., Marciniak, Anna, Moravec, Z., Delinčák, P., Gianni, G., Casalnuovo, G.B., Isopi, G., Tsamis, V., Boutet, M., Sanchez, J., Trigo-Rodríguez, Josep M., Duffard, René, Renner, S., Rousselot, L., Margoti, G., Kubánek, J., André, P., Krugly, Yurij, Colazo, C., Spagnotto, J., Sickafoose, A.A., Hueso, R., Sánchez-Lavega, A., Fisher, R.S., Conjat, M., Lecacheux, J., Rengstorf, A.W., Perelló, C., Slyusarev, I., Vara-Lubiano, M., Dascalu, M., Castro-Tirado, Alberto J., Tigani, K., Sioulas, Nick, Lekkas, G., Bertesteanu, D.N., Bachini, M., Dumitrescu, V., Wilberger, A.J., Chiorny, V., Barnes, J.W., Fieber-Beyer, S.K., Swaney, R.L., Fuentes, C., Hudin, L., Plouvier, J.L., Mendez, R.A., Dumitru, B.D., Succi, G., Flynn, R.L., Mikuz, H., Wake, D.A., Morales, Nicolás, Maury, Alain, Fabrega, J., Ceravolo, P., Jehin, Emmanuel, Madiedo, J.M., Albanese, D., Mariey, H., Stoian, L., Bacci, P., Cikota, S., Ruždjak, D., Cikota, A., Szakáts, Róbert, Baba Aissa, D., Gringahcene, Z., Kashuba, V., Koshkin, N., Anghel, R.M., Zhukov, V., Maestripieri, M., Juravle, A., Fişek, S., Çakir, O., Özer, S., Schnabel, C., Schnabel, M., Signoret, F., Morrone, L., Santana-Ros, Toni, Pereira, C.L., Grazia, M.D., Calvo-Fernández, J.F., Carosati, D., Emilio, M., Burdanov, A.Y., de Wit, J., Barkaoui, K., Gillon, M., Leto, G., Frasca, A., Catanzaro, G., Carrillo, J., Zanmar Sanchez, R., Tagliaferri, U., Gowe, B., Valvasori, A., Klemt, B., de la Cueva, I., Guido, E., Yuste-Moreno, M., Ciabattari, F., Kozhukhov, O.M., Serra-Ricart, M., Alarcon, Miguel R., Licandro, Javier, Masi, G., Bacci, Roberto, Wuensche, N., Kamoun, S., Bosch, Josep M., Behem, R., Gherase, R.M., Prost, J.-P., Altan, M., Zheleznyak, A.P., Montigiani, N., Foster, C.R., Mannucci, M., Burzynski, W., Ruocco, Nello, Cuevas, F., Di Marcantonio, P., Coretti, I., Iafrate, G., Baldini, V., Gazeas, K., Fafet, R., Collins, M., Pál, András, Borkowski, M., Csák, B., Fernández-García, Emilio, Benedetti-Rossi, G., Sánchez-González, M., Curelaru, L., Vîntdevară, C.D., Danescu, C.A., de Santana, T., Gout, J.-F., Schmitz, C.J., Serrau, M., Sota, Alfredo, Belskaya, Irina, Rodríguez-Marco, M., Kilic, Y., Gomes-Júnior, A.R., Frappa, E., Klotz, A., Lavayssière, M., Sfair, R., Marques Oliveira, J., Dangl, G., Popescu, Marcel, Mammana, L.A., Fernández-Lajús, E., Schmidt, M., Hopp, U., Komžík, R., Fernández-Valenzuela, Estela, Pribulla, T., Tomko, D., Winter, O.C., Klös, O., Husárik, Marek, Erece, O., Eryilmaz, S., Buzzi, Luca, Gährken, B., Nardiello, D., Hornoch, Kamil, Sonbas, E., Holler, B.J., Er, H., Weber, C., Kalkan, S., Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Rommel, F.L., Braga-Ribas, F., Ortiz Moreno, José Luis, Sicardy, B., Santos Sanz, Pablo, Desmars, Josselin, Camargo, J.I.B., Vieira-Martins, R., Assafin, M., Morgado, B.E., Boufleur, R.C., Burwitz, V., Waldemar Sybilski, P., Bykowski, W., Müller, Thomas G., Ogloza, W., Gonçalves, R., Ferreira, J.F., Ferreira, M., Bento, M., Urbaník, M., Di Sora, M., Souami, Damya, Canales-Moreno, O., Meister, S., Bagiran, M.N., Tekeş, M., Marciniak, Anna, Moravec, Z., Delinčák, P., Gianni, G., Casalnuovo, G.B., Isopi, G., Tsamis, V., Boutet, M., Sanchez, J., Trigo-Rodríguez, Josep M., Duffard, René, Renner, S., Rousselot, L., Margoti, G., Kubánek, J., André, P., Krugly, Yurij, Colazo, C., Spagnotto, J., Sickafoose, A.A., Hueso, R., Sánchez-Lavega, A., Fisher, R.S., Conjat, M., Lecacheux, J., Rengstorf, A.W., Perelló, C., Slyusarev, I., Vara-Lubiano, M., Dascalu, M., Castro-Tirado, Alberto J., Tigani, K., Sioulas, Nick, Lekkas, G., Bertesteanu, D.N., Bachini, M., Dumitrescu, V., Wilberger, A.J., Chiorny, V., Barnes, J.W., Fieber-Beyer, S.K., Swaney, R.L., Fuentes, C., Hudin, L., Plouvier, J.L., Mendez, R.A., Dumitru, B.D., Succi, G., Flynn, R.L., Mikuz, H., Wake, D.A., Morales, Nicolás, Maury, Alain, Fabrega, J., Ceravolo, P., Jehin, Emmanuel, Madiedo, J.M., Albanese, D., Mariey, H., Stoian, L., Bacci, P., Cikota, S., Ruždjak, D., Cikota, A., Szakáts, Róbert, Baba Aissa, D., Gringahcene, Z., Kashuba, V., Koshkin, N., Anghel, R.M., Zhukov, V., Maestripieri, M., Juravle, A., Fişek, S., Çakir, O., Özer, S., Schnabel, C., Schnabel, M., Signoret, F., Morrone, L., Santana-Ros, Toni, Pereira, C.L., Grazia, M.D., Calvo-Fernández, J.F., Carosati, D., Emilio, M., Burdanov, A.Y., de Wit, J., Barkaoui, K., Gillon, M., Leto, G., Frasca, A., Catanzaro, G., Carrillo, J., Zanmar Sanchez, R., Tagliaferri, U., Gowe, B., Valvasori, A., Klemt, B., de la Cueva, I., Guido, E., Yuste-Moreno, M., Ciabattari, F., Kozhukhov, O.M., Serra-Ricart, M., Alarcon, Miguel R., Licandro, Javier, Masi, G., Bacci, Roberto, Wuensche, N., Kamoun, S., Bosch, Josep M., Behem, R., Gherase, R.M., Prost, J.-P., Altan, M., Zheleznyak, A.P., Montigiani, N., Foster, C.R., Mannucci, M., Burzynski, W., Ruocco, Nello, Cuevas, F., Di Marcantonio, P., Coretti, I., Iafrate, G., Baldini, V., Gazeas, K., Fafet, R., Collins, M., Pál, András, Borkowski, M., Csák, B., Fernández-García, Emilio, Benedetti-Rossi, G., Sánchez-González, M., Curelaru, L., Vîntdevară, C.D., Danescu, C.A., de Santana, T., Gout, J.-F., Schmitz, C.J., Serrau, M., Sota, Alfredo, Belskaya, Irina, Rodríguez-Marco, M., Kilic, Y., Gomes-Júnior, A.R., Frappa, E., Klotz, A., Lavayssière, M., Sfair, R., Marques Oliveira, J., Dangl, G., Popescu, Marcel, Mammana, L.A., Fernández-Lajús, E., Schmidt, M., Hopp, U., Komžík, R., Fernández-Valenzuela, Estela, Pribulla, T., Tomko, D., Winter, O.C., Klös, O., Husárik, Marek, Erece, O., Eryilmaz, S., Buzzi, Luca, Gährken, B., Nardiello, D., Hornoch, Kamil, Sonbas, E., Holler, B.J., Er, H., Weber, C., and Kalkan, S.
- Abstract
Context. The physical characterization of trans-Neptunian objects is essential for improving our understanding of the formation and evolution of our Solar System. Stellar occultation is a ground-based technique that can be successfully used to determine some of the TNOs’ fundamental physical properties with high precision, such as size and shape. Aims. This work is aimed at constraining the size, shape, and geometric albedo of the dwarf planet candidate (307261) 2002 MS4 through the analysis of nine stellar occultation events. Using multichord detection, we also study the object’s topography by analyzing the obtained limb and residuals between the observed chords and the best-fit ellipse. Metods. We predicted and organized the observational campaigns of nine stellar occultations by 2002 MS4 between 2019 and 2022, resulting in two single-chord events, four double-chord detections, and three events with between 3 and 61 positive chords. We derived the occultation light curves using differential aperture photometry, from which the star ingress and egress instants were calculated. Using 13 selected chords from the 8 August 2020 event, we determined the global elliptical limb of 2002 MS4. The best-fit ellipse, combined with the object’s rotational information from the literature, sets constraints on the object’s size, shape, and albedo. Additionally, we developed a new method to characterize the topography features on the object’s limb. Results. The global limb has a semi-major axis of a′ = 412 ± 10 km, a semi-minor axis of b′= 385 ± 17 km, and the position angle of the minor axis is 121° ± 16°. From this instantaneous limb, we obtained 2002 MS4’s geometric albedo of pV = 0.1 ± 0.025, using HV = 3.63 ± 0.05 mag and a projected area-equivalent diameter of 796 ± 24 km. Significant deviations from the fitted ellipse in the northernmost limb were detected from multiple sites, highlighting three distinct topographic features: one 11 km depth depression, followed by a 25−5+4 k
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- 2023
243. TOI-179 : A young system with a transiting compact Neptune-mass planet and a low-mass companion in outer orbit
- Author
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Desidera, S., Damasso, M., Gratton, R., Benatti, S., Nardiello, D., D'Orazi, V., Lanza, A. F., Locci, D., Marzari, F., Mesa, D., Messina, S., Pillitteri, I., Sozzetti, A., Girard, J., Maggio, A., Micela, G., Malavolta, L., Nascimbeni, V., Pinamonti, M., Squicciarini, V., Alcala, J., Biazzo, K., Bohn, A., Bonavita, M., Brooks, K., Chauvin, G., Covino, E., Delorme, P., Hagelberg, J., Janson, Markus, Lagrange, A. -M., Lazzoni, C., Desidera, S., Damasso, M., Gratton, R., Benatti, S., Nardiello, D., D'Orazi, V., Lanza, A. F., Locci, D., Marzari, F., Mesa, D., Messina, S., Pillitteri, I., Sozzetti, A., Girard, J., Maggio, A., Micela, G., Malavolta, L., Nascimbeni, V., Pinamonti, M., Squicciarini, V., Alcala, J., Biazzo, K., Bohn, A., Bonavita, M., Brooks, K., Chauvin, G., Covino, E., Delorme, P., Hagelberg, J., Janson, Markus, Lagrange, A. -M., and Lazzoni, C.
- Abstract
Context. Transiting planets around young stars are key benchmarks for our understanding of planetary systems. One such candidate, TOI-179, was identified around the K dwarf HD 18599 by TESS.Aims. We present the confirmation of the transiting planet and the characterization of the host star and of the TOI-179 system over a broad range of angular separations.Methods. We exploited the TESS photometric time series, intensive radial velocity monitoring performed with HARPS, and deep high-contrast imaging observations obtained with SPHERE and NACO at VLT. The inclusion of Gaussian process regression analysis was effective to properly model the magnetic activity of the star and identify the Keplerian signature of the transiting planet.Results. The star, with an age of 400 & PLUSMN;100 Myr, is orbited by a transiting planet with period 4.137436 days, mass 24 & PLUSMN;7 M-& OPLUS;, radius 2.62(-0.12)(+0.15) R-& OPLUS;, and significant eccentricity (0.34(-0.09)(+0.07)). Adaptive optics observations identified a low-mass companion at the boundary between brown dwarfs and very low-mass stars (mass derived from luminosity 83(-6)(+4) M-J) at a very small projected separation (84.5 mas, 3.3 au at the distance of the star). Coupling the imaging detection with the long-term radial velocity trend and the astrometric signature, we constrained the orbit of the low-mass companion, identifying two families of possible orbital solutions.Conclusions. The TOI-179 system represents a high-merit laboratory for our understanding of the physical evolution of planets and other low-mass objects and of how the planet properties are influenced by dynamical effects and interactions with the parent star.
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- 2023
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244. Hyades Member K2-136c:The Smallest Planet in an Open Cluster with a Precisely Measured Mass
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Mayo, Andrew W., Dressing, Courtney D., Vanderburg, Andrew, Fortenbach, Charles D., Lienhard, Florian, Malavolta, Luca, Mortier, Annelies, Núñez, Alejandro, Richey-Yowell, Tyler, Turtelboom, Emma V., Bonomo, Aldo S., Latham, David W., López-Morales, Mercedes, Shkolnik, Evgenya, Sozzetti, Alessandro, Agüeros, Marcel A., Borsato, Luca, Charbonneau, David, Cosentino, Rosario, Douglas, Stephanie T., Dumusque, Xavier, Ghedina, Adriano, Gibson, Rose, Granata, Valentina, Harutyunyan, Avet, Haywood, R. D., Lacedelli, Gaia, Lorenzi, Vania, Magazzù, Antonio, Martinez Fiorenzano, A. F., Micela, Giuseppina, Molinari, Emilio, Montalto, Marco, Nardiello, Domenico, Nascimbeni, Valerio, Pagano, Isabella, Piotto, Giampaolo, Pino, Lorenzo, Poretti, Ennio, Scandariato, Gaetano, Udry, Stephane, Buchhave, Lars A., Mayo, Andrew W., Dressing, Courtney D., Vanderburg, Andrew, Fortenbach, Charles D., Lienhard, Florian, Malavolta, Luca, Mortier, Annelies, Núñez, Alejandro, Richey-Yowell, Tyler, Turtelboom, Emma V., Bonomo, Aldo S., Latham, David W., López-Morales, Mercedes, Shkolnik, Evgenya, Sozzetti, Alessandro, Agüeros, Marcel A., Borsato, Luca, Charbonneau, David, Cosentino, Rosario, Douglas, Stephanie T., Dumusque, Xavier, Ghedina, Adriano, Gibson, Rose, Granata, Valentina, Harutyunyan, Avet, Haywood, R. D., Lacedelli, Gaia, Lorenzi, Vania, Magazzù, Antonio, Martinez Fiorenzano, A. F., Micela, Giuseppina, Molinari, Emilio, Montalto, Marco, Nardiello, Domenico, Nascimbeni, Valerio, Pagano, Isabella, Piotto, Giampaolo, Pino, Lorenzo, Poretti, Ennio, Scandariato, Gaetano, Udry, Stephane, and Buchhave, Lars A.
- Abstract
K2-136 is a late-K dwarf (0.742 ± 0.039 M ⊙) in the Hyades open cluster with three known, transiting planets and an age of 650 ± 70 Myr. Analyzing K2 photometry, we found that planets K2-136b, c, and d have periods of 8.0, 17.3, and 25.6 days and radii of 1.014 ± 0.050 R ⊕, 3.00 ± 0.13 R ⊕, and 1.565 ± 0.077 R ⊕, respectively. We collected 93 radial velocity (RV) measurements with the High-Accuracy Radial-velocity Planet Searcher for the Northern hemisphere (HARPS-N) spectrograph (Telescopio Nazionale Galileo) and 22 RVs with the Echelle SPectrograph for Rocky Exoplanets and Stable Spectroscopic Observations (ESPRESSO) spectrograph (Very Large Telescope). Analyzing HARPS-N and ESPRESSO data jointly, we found that K2-136c induced a semi-amplitude of 5.49 ± 0.53 m s−1, corresponding to a mass of 18.1 ± 1.9 M ⊕. We also placed 95% upper mass limits on K2-136b and d of 4.3 and 3.0 M ⊕, respectively. Further, we analyzed Hubble Space Telescope and XMM-Newton observations to establish the planetary high-energy environment and investigate possible atmospheric loss. K2-136c is now the smallest planet to have a measured mass in an open cluster and one of the youngest planets ever with a mass measurement. K2-136c has ∼75% the radius of Neptune but is similar in mass, yielding a density of 3.69 − 0.56 + 0.67 g cm−3 (∼2-3 times denser than Neptune). Mass estimates for K2-136b (and possibly d) may be feasible with more RV observations, and insights into all three planets’ atmospheres through transmission spectroscopy would be challenging but potentially fruitful. This research and future mass measurements of young planets are critical for investigating the compositions and characteristics of small exoplanets at very early stages of their lives and providing insights into how exoplanets evolve with time.
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- 2023
245. Successful Brain Delivery of Andrographolide Loaded in Human Albumin Nanoparticles to TgCRND8 Mice, an Alzheimer’s Disease Mouse Model
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Anna Rita Bilia, Pamela Nardiello, Vieri Piazzini, Manuela Leri, Maria Camilla Bergonzi, Monica Bucciantini, and Fiorella Casamenti
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andrographolide ,blood-brain barrier ,human albumin nanoparticles ,TgCRND8 mice ,step-down inhibitory avoidance test ,object recognition test ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Andrographolide (AG) was encapsulated in human albumin nanoparticles (AG NPs), and their crossing properties of the blood-brain barrier (BBB), brain distribution, and effects in TgCRND8 mice were evaluated. The development of appropriate NP formulations is mandatory because of the scarce BBB permeability properties of AG. Developed NPs had proper size (mean size: 159.2 ± 4.5 nm), size distribution (PDI nearby 0.12 ± 0.01), and ζ potential (-24.8 ± 1.2 mV), which were not affected by sodium fluorescein (NAF) loading. When AG was loaded to NPs, it slightly affected their size (210.4 ± 3.2 nm) and ζ potential (-20.3 ± 1.5) but not the PDI. Both NAF and AG had a remarkable encapsulation efficiency (more than 99%). The in vitro release of AG from the NPs reached the highest percentage (48%) after 24 h, and the Higuchi’s equation was found to be the best fitting model (R2 = 0.9635). Both AG and AG NPs did not alter the viability of N2a murine neuroblastoma cells when compared with the untreated control cells. In the step-down inhibitory avoidance test, AG NPs administered to TgCRND8 mice significantly improved their performance (P < 0.0001), reaching levels comparable to those displayed by wild-type mice. In the object recognition test, treated and untreated animals showed no deficiencies in exploratory activity, directional movement toward objects, and locomotor activity. No cognitive impairments (discrimination score) were detected in TgCRND8 mice (P < 0.0001) treated with AG NPs. After acute intravenous administration (200 µl), NPs loaded with the probe NAF were detected in the brain parenchyma of TgCRND8 mice. Immunofluorescent analyses evidenced the presence of NPs both in the pE3-Aβ plaque surroundings and inside the pE3-Aβ plaque, indicative of the ability of these NPs to cross the BBB and to penetrate in both undamaged and damaged brain tissues. Furthermore, the immunohistochemical analysis of GFAP-positive astrocytes in the hippocampus of Tg mice evidenced the anti-inflammatory activity of AG when AG NPs were intraperitoneally administered. AG was not effective in counteracting amyloid Aβ aggregation and the resulting toxicity but significantly decreased the oxidative stress levels. In conclusion, AG NPs have extraordinary versatility, nontoxicity, nonimmunogenicity, strong biocompatibility, high biodegradability, and astonishing loading capacity of drug.
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- 2019
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246. Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties
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Monica Bucciantini, Manuela Leri, Pamela Nardiello, Fiorella Casamenti, and Massimo Stefani
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EVOO polyphenols ,oxidative stress ,inflammation ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Oxidative stress and inflammation triggered by increased oxidative stress are the cause of many chronic diseases. The lack of anti-inflammatory drugs without side-effects has stimulated the search for new active substances. Plant-derived compounds provide new potential anti-inflammatory and antioxidant molecules. Natural products are structurally optimized by evolution to serve particular biological functions, including the regulation of endogenous defense mechanisms and interaction with other organisms. This property explains their relevance for infectious diseases and cancer. Recently, among the various natural substances, polyphenols from extra virgin olive oil (EVOO), an important element of the Mediterranean diet, have aroused growing interest. Extensive studies have shown the potent therapeutic effects of these bioactive molecules against a series of chronic diseases, such as cardiovascular diseases, diabetes, neurodegenerative disorders and cancer. This review begins from the chemical structure, abundance and bioavailability of the main EVOO polyphenols to highlight the effects and the possible molecular mechanism(s) of action of these compounds against inflammation and oxidation, in vitro and in vivo. In addition, the mechanisms of inhibition of molecular signaling pathways activated by oxidative stress by EVOO polyphenols are discussed, together with their possible roles in inflammation-mediated chronic disorders, also taking into account meta-analysis of population studies and clinical trials.
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- 2021
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247. A New Recognition Procedure for Palmprint Features Extraction from Ultrasound Images
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Nardiello, Donatella, primary and Iula, Antonio, additional
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- 2018
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248. Fever of unknown origin (FUO): which are the factors influencing the final diagnosis? A 2005–2015 systematic review
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Fusco, Francesco Maria, Pisapia, Raffaella, Nardiello, Salvatore, Cicala, Stefano Domenico, Gaeta, Giovanni Battista, and Brancaccio, Giuseppina
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- 2019
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249. Targeting miR‐34a/Pdgfra interactions partially corrects alveologenesis in experimental bronchopulmonary dysplasia
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Ruiz‐Camp, Jordi, Quantius, Jennifer, Lignelli, Ettore, Arndt, Philipp F, Palumbo, Francesco, Nardiello, Claudio, Surate Solaligue, David E, Sakkas, Elpidoforos, Mižíková, Ivana, Rodríguez‐Castillo, José Alberto, Vadász, István, Richardson, William D, Ahlbrecht, Katrin, Herold, Susanne, Seeger, Werner, and Morty, Rory E
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- 2019
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250. Supplementary Figures S1-S3 from MAGE-A Inhibits Apoptosis in Proliferating Myeloma Cells through Repression of Bax and Maintenance of Survivin
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Nardiello, Tricia, primary, Jungbluth, Achim A., primary, Mei, Anna, primary, DiLiberto, Maurizio, primary, Huang, Xiangao, primary, Dabrowski, Ania, primary, Andrade, Valéria C.C., primary, Wasserstrum, Rebecca, primary, Ely, Scott, primary, Niesvizky, Ruben, primary, Pearse, Roger, primary, Coleman, Morton, primary, Jayabalan, David S., primary, Bhardwaj, Nina, primary, Old, Lloyd J., primary, Chen-Kiang, Selina, primary, and Cho, Hearn Jay, primary
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- 2023
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