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300 results on '"Naoki, Takano"'

216. 536 Mechanical Analysis of Trabecular Bone of Vertebra for Osteoporosis Patients : Computational Analysis by Homogenization Method

Author

Kunio Takaoka, Takayoshi Nakano, Mitsuhiro Kawagai, Hiroyoshi Iwaki, Naoki Takano, Takatoshi Enokimoto, Akio Kobayashi, Taiji Adachi, Daisuke Tawara, and Yukichi Umakoshi

Subjects
Trabecular bone, Materials science, medicine.anatomical_structure, Osteoporosis, medicine, Computational analysis, medicine.disease, Vertebra, Biomedical engineering, Homogenization (biology)
Published
2006
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226. A213 Computational mechanics approach to osteoporosis diagnosis by means of multi-scale stress analysis of trabecular bone

Author

Mitsuhiro Kawagai, Takayoshi Nakano, Taiji Adachi, Naoki Takano, Takatoshi Enokimoto, Atsushi Sando, Noriyuki Kushida, and Yukichi Umakoshi

Subjects
Stress (mechanics), Trabecular bone, Scale (ratio), business.industry, Computer science, Computational mechanics, Osteoporosis, medicine, Structural engineering, business, medicine.disease
Published
2005
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246. F407 Practical Monte Carlo Simulation for Highly Non-Linear Problem

Author

Naoki Takano, Kohta Okamoto, and Yuta Shimizu

Subjects
Hybrid Monte Carlo, Mathematical optimization, Computer science, Quantum Monte Carlo, Monte Carlo method, Dynamic Monte Carlo method, Applied mathematics, Monte Carlo method in statistical physics, Monte Carlo integration, Quasi-Monte Carlo method, Monte Carlo molecular modeling
Published
2011
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250. Formation of polymer microneedle arrays using soft lithography

Author

Hiroto Tachikawa, Norihisa Miki, Naoki Takano, and Yoshimichi Ami

Subjects
Materials science, integumentary system, Polydimethylsiloxane, Mechanical Engineering, Nanotechnology, Photoresist, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Soft lithography, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Stratum corneum, medicine, Electrical and Electronic Engineering, Composite material, Photomask, Lithography, Microfabrication, Transdermal
Abstract

We demonstrate the fabrication of polymer microneedle arrays using soft lithography. A photomask was designed to use Fresnel diffraction of UV light to create sharp, tapered hollows in SU-8, a negative photoresist, after development. Polymer microneedles were formed using these SU-8 structures as a mold. These polymer needles may be applicable as flexible electrodes in brain-machine interfaces because they are more likely to survive movement of the skin than conventional brittle silicon needles. Similar needles, made from medicinal substances, could be used for transdermal drug administration. For these applications, the needles must be long, sharp, and stiff enough to penetrate the stratum corneum (∼20 μm in thickness) and reach the viable epidermis (200-300 μm in thickness), but must not reach the dermis, which contains sensitive nerve endings. We successfully manufactured 20×20 microneedle arrays of polydimethylsiloxane with a needle length of 200 μm. We experimentally verified that these manufactured electrodes successfully penetrated the stratum corneum of a cultured skin.

Published
2011
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