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4,650 results on '"Nakajima, S."'

204. On robust parameter estimation in brain-computer interfacing

Author

Samek, W., Nakajima, S., Kawanabe, M., Müller, K.-R., and Publica

Abstract

Objective. The reliable estimation of parameters such as mean or covariance matrix from noisy and high-dimensional observations is a prerequisite for successful application of signal processing and machine learning algorithms in brain-computer interfacing (BCI). This challenging task becomes significantly more difficult if the data set contains outliers, e.g. due to subject movements, eye blinks or loose electrodes, as they may heavily bias the estimation and the subsequent statistical analysis. Although various robust estimators have been developed to tackle the outlier problem, they ignore important structural information in the data and thus may not be optimal. Typical structural elements in BCI data are the trials consisting of a few hundred EEG samples and indicating the start and end of a task. Approach. This work discusses the parameter estimation problem in BCI and introduces a novel hierarchical view on robustness which naturally comprises different types of outlierness occurring in structured data. Furthermore, the class of minimum divergence estimators is reviewed and a robust mean and covariance estimator for structured data is derived and evaluated with simulations and on a benchmark data set. Main results. The results show that state-of-the-art BCI algorithms benefit from robustly estimated parameters. Significance. Since parameter estimation is an integral part of various machine learning algorithms, the presented techniques are applicable to many problems beyond BCI.

Published
2017

205. Single Molecular Resistive Switch Obtained via Sliding Multiple Anchoring Points and Varying Effective Wire Length

Author

Kiguchi, M., Ohto, T., Fujii, Shintaro, Sugiyasu, K., Nakajima, S., Takeuchi, M., and Nakamura, H.

Subjects
Resistive touchscreen, Chemistry, Anchoring, Conductance, Nanotechnology, General Chemistry, Biochemistry, Molecular physics, Catalysis, law.invention, Molecular wire, Colloid and Surface Chemistry, law, Distortion, Exponential decay, Scanning tunneling microscope, Break junction
Abstract

A single molecular resistive (conductance) switch via control of anchoring positions was examined by using a molecule consisting of more than two same anchors. For this purpose, we adopted the covered quaterthiophene (QT)-based molecular wire junction. The QT-based wire consisted of two thiophene ring anchors on each side; thus, shift of anchors was potentially possible without a change in the binding modes and distortion of the intramolecular structure. We observed three distinct conductance states by using scanning tunneling microscope-based break junction technique. A detailed analysis of the experimental data and first-principles calculations revealed that the mechanism of the resistive switch could be explained by standard length dependence (exponential decay) of conductance. Here, the length is the distance between the anchoring points, i.e., length of the bridged π-conjugated backbone. Most importantly, this effective tunneling length was variable via only controlling the anchoring positions in the same molecule. Furthermore, we experimentally showed the possibility of a dynamic switch of anchoring positions by mechanical control. The results suggested a distinct strategy to design functional devices via contact engineering.

Published
2014

209. First direct mass measurements of stored neutron-rich 129,130,131Cd isotopes with FRS-ESR

Author

Knöbel, R., Diwisch, M., Bosch, F., Boutin, D., Chen, L., Dimopoulou, C., Dolinskii, A., Franczak, B., Franzke, B., Geissel, H., Hausmann, M., Kozhuharov, C., Kurcewicz, J., Litvinov, S.A., Martinez-Pinedo, G., Matoš, M., Mazzocco, M., Münzenberg, G., Nakajima, S., Nociforo, C., Nolden, F., Ohtsubo, T., Ozawa, A., Patyk, Z., Plaß, W.R., Scheidenberger, C., Stadlmann, J., Steck, M., Sun, B., Suzuki, T., Walker, P.M., Weick, H., Wu, M.-R., Winkler, M., and Yamaguchi, T.

Published
2016
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212. 555 Integrating serum and skin biomarkers to assess disease extent beyond clinical scores, advancing precision therapeutics

Author

Malik, K., primary, Czarnowicki, T., additional, Wen, H., additional, Noda, S., additional, Pavel, A.B., additional, Nakajima, S., additional, Honda, T., additional, Shin, J.U., additional, Lee, H., additional, Krueger, J.G., additional, Lee, K., additional, Kabashima, K., additional, and Guttman-Yassky, E., additional

Published
2018
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215. Paradoxical Reaction of Tuberculosis in a Heart Transplant Recipient During Antituberculosis Therapy: A Case Report

Author

Wakamiya, A., primary, Seguchi, O., additional, Shionoiri, A., additional, Kumai, Y., additional, Kuroda, K., additional, Nakajima, S., additional, Yanase, M., additional, Matsuda, S., additional, Wada, K., additional, Matsumoto, Y., additional, Fukushima, S., additional, Fujita, T., additional, Kobayashi, J., additional, and Fukushima, N., additional

Published
2018
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223. Laparoscopic Training Using the Human “Mirror Neuron System”

Author

Oyama, K., primary, Kanno, K., additional, Ichikawa, F., additional, Nimura, R., additional, Matsumoto, T., additional, Kojima, R., additional, Shirane, A., additional, Yanai, S., additional, Nakajima, S., additional, Ebisawa, K., additional, Hada, T., additional, Ota, Y., additional, and Andou, M., additional

Published
2017
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224. Exome analysis of autosomal recessive or sporadic cases of cerebellar ataxia and spastic paraplegia

Author

Doi, H., primary, Shigeru, K., additional, Misako, K., additional, Miyatake, S., additional, Nakajima, S., additional, Shunta, H., additional, Shingo, I., additional, Shun, K., additional, Noriko, H., additional, Yuki, O., additional, Keita, T., additional, Kenichi, T., additional, Mikiko, T., additional, Hideyuki, T., additional, Naomichi, M., additional, and Fumiaki, T., additional

Published
2017
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232. Cortical Amyloid β Deposition and Current Depressive Symptoms in Alzheimer Disease and Mild Cognitive Impairment

Author

Chung, JK, Plitman, E, Nakajima, S, Chakravarty, MM, Caravaggio, F, Gerretsen, P, Iwata, Y, Graff-Guerrero, A, and Alzheimer’s Disease Neuroimaging Initiative

Subjects
Cerebral Cortex, Male, Depressive Disorder, Major, Aniline Compounds, Amyloid beta-Peptides, Depression, Neuroimaging, Alzheimer’s Disease Neuroimaging Initiative, Middle Aged, Alzheimer Disease, Positron-Emission Tomography, Humans, Ethylene Glycols, Female, Cognitive Dysfunction, Aged
Abstract

Depressive symptoms are frequently seen in patients with dementia and mild cognitive impairment (MCI). Evidence suggests that there may be a link between current depressive symptoms and Alzheimer disease (AD)-associated pathological changes, such as an increase in cortical amyloid-β (Aβ). However, limited in vivo studies have explored the relationship between current depressive symptoms and cortical Aβ in patients with MCI and AD. Our study, using a large sample of 455 patients with MCI and 153 patients with AD from the Alzheimer's disease Neuroimaging Initiatives, investigated whether current depressive symptoms are related to cortical Aβ deposition. Depressive symptoms were assessed using the Geriatric Depression Scale and Neuropsychiatric Inventory-depression/dysphoria. Cortical Aβ was quantified using positron emission tomography with the Aβ probe(18)F-florbetapir (AV-45).(18)F-florbetapir standardized uptake value ratio (AV-45 SUVR) from the frontal, cingulate, parietal, and temporal regions was estimated. A global AV-45 SUVR, defined as the average of frontal, cingulate, precuneus, and parietal cortex, was also used. We observed that current depressive symptoms were not related to cortical Aβ, after controlling for potential confounds, including history of major depression. We also observed that there was no difference in cortical Aβ between matched participants with high and low depressive symptoms, as well as no difference between matched participants with the presence and absence of depressive symptoms. The association between depression and cortical Aβ deposition does not exist, but the relationship is highly influenced by stressful events in the past, such as previous depressive episodes, and complex interactions of different pathways underlying both depression and dementia.

Published
2016

235. [Successful treatment with acyclovir and a corticosteroid for lower cranial polyneuropathy in zoster sine herpete: a case report]

Author

Taniguchi D, Nakazato T, Furukawa Ph D Y, Nakajima S, Mikasa M, and Nakahara Ph D T

Subjects
medicine.medical_specialty, viruses, Acyclovir, medicine.disease_cause, Antiviral Agents, Methylprednisolone, Zoster Sine Herpete, Lesion, Neuritis, Paralysis, medicine, Humans, business.industry, Cranial nerves, Varicella zoster virus, virus diseases, Middle Aged, medicine.disease, Cranial Nerve Diseases, Surgery, medicine.anatomical_structure, Treatment Outcome, Anesthesia, Drug Therapy, Combination, Female, Neurology (clinical), medicine.symptom, business, Polyneuropathy, Meningitis, Jugular foramen, medicine.drug
Abstract

A 62-year-old woman developed meningitis as well as acute paralysis of glossopharyngeal, vagus, and accessory nerves on the right side and also had dysfunction of the left hypoglossal nerve. Although there was no evidence of a typical cutaneous or mucosal herpetic lesion, PCR detection of varicella zoster virus (VZV)-DNA in cerebrospinal fluid confirmed the clinical diagnosis of polyneuritis cranialis due to VZV infection and zoster sine herpete. After starting intravenous acyclovir and methylprednisolone, her hypoglossal nerve palsy disappeared within a day and all other symptoms and signs dramatically improved. A rapid improvement observed in our patient suggests that the right cranial polyneuropathy could be caused by inflammation associated with epineurial edema (where the ninth, tenth, and eleventh cranial nerves pass through the right jugular foramen), whereas the exact mechanism of the twelfth cranial nerve involvement on the contralateral side is unknown. Our clinical findings indicate that acute lower cranial polyneuropathy in patients with zoster sine herpete should be treated immediately with combined administration of acyclovir and an anti-inflammatory corticosteroid.

Published
2015

236. Poster discussions

Author

Ikeda, K., Ikeda, T., Sugi, M., Ishii, N., Mikoshiba, M., Nakajima, S., Hukuda, T., Hasue, M., Kvetan, V., Hino, H., Lu, G., Lis, R. J., Nagashima, H., McKeating, E. G., Mascia, L., Signorini, D. F., Andrews, P. J. D., Himmelseher, S., Stahl, B., Pfenninger, E., Georgieff, M., Kolbitsch, Ch., Hörmann, Ch., Schmidauer, Ch., and Benzer, A.

Published
1996
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241. Three-dimensional evaluation of subclinical extension of extramammary Paget disease: visualization of the histological border and its comparison to the clinical border

Author

Murata, T., primary, Honda, T., additional, Egawa, G., additional, Kitoh, A., additional, Dainichi, T., additional, Otsuka, A., additional, Nakajima, S., additional, Kore-eda, S., additional, Kaku, Y., additional, Nakamizo, S., additional, Endo, Y., additional, Fujisawa, A., additional, Miyachi, Y., additional, and Kabashima, K., additional

Published
2017
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243. 298 RNA-seq profiling highlights the robust inflammation and Th17-skewing of the non-lesional Asian atopic dermatitis phenotype

Author

Wen, H., primary, Malik, K., additional, Noda, S., additional, Ungar, B., additional, Suprun, M., additional, Nakajima, S., additional, Honda, T., additional, Lee, H., additional, Suarez-Farinas, M., additional, Krueger, J.G., additional, Kabashima, K., additional, Lee, K., additional, and Guttman-Yassky, E., additional

Published
2017
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245. Japanese Experience of Heartmate II Left Ventricular Assist Device: Does Low Pump Speed Really Matter? Experience of Heartmate II Left Ventricular Assist Device:Does Low Pump Speed Really Matter?

Author

Seguchi, O., primary, Kuroda, K., additional, Nakajima, S., additional, Sunami, H., additional, Sato, T., additional, Yanase, M., additional, Matsumoto, Y., additional, Hata, H., additional, Fujita, T., additional, Kobayashi, J., additional, and Fukushima, N., additional

Published
2017
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246. Incidence of Gastrointestinal Bleeding and Acquired von Willebrand Syndrome in Japanese Recipients of Continuous-Flow Left Ventricular Assist Devices -Comparison Between Axial and Centrifugal-Flow Pumps

Author

Nakajima, S., primary, Kuroda, K., additional, Sunami, H., additional, Sato, T., additional, Seguchi, O., additional, Yanase, M., additional, Matsumoto, Y., additional, Hata, H., additional, Fujita, T., additional, Kobayashi, J., additional, and Fukushima, N., additional

Published
2017
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