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Stroke prevention with oral anticoagulants in patients with atrial fibrillation predisposes for bleeding. As a result, in select patient groups anticoagulation is withheld because of a perceived unfavorable risk-benefit ratio. Reasons for withholding anticoagulation can vary greatly between clinicians, often leading to discussion in daily clinical practice on the best approach. To guide clinical decision-making, we have reviewed available evidence on the most frequently reported reasons for withholding anticoagulation: previous bleeding, frailty and age, and an overall high bleeding risk. [ABSTRACT FROM AUTHOR]

A fast and accurate numerical method for the solution of scalar and matrix Wiener–Hopf (WH) problems is presented. The WH problems are formulated as Riemann–Hilbert problems on the real line, and a numerical approach developed for these problems is used. It is shown that the known far-field behaviour of the solutions can be exploited to construct numerical schemes providing spectrally accurate results. A number of scalar and matrix WH problems that generalize the classical Sommerfeld problem of diffraction of plane waves by a semi-infinite plane are solved using the approach. [ABSTRACT FROM AUTHOR]

Some properties of characteristic curves in connection with the viscosity solution of the Hamilton-Jacobi equation defined by the Hopf formula are studied. We are concerned with the points at which the solution u(t, x) is differentiable, and the strip of the form in the domain where u(t, x) is of class [ABSTRACT FROM AUTHOR]

Neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNC) play central roles in reward‐related behaviours. Nonhuman animal studies suggest that these neurons also process aversive events. However, our understanding of how the human VTA and SNC responds to such events is limited and has been hindered by the technical challenge of using functional magnetic resonance imaging (fMRI) to investigate a small structure where the signal is particularly vulnerable to physiological noise. Here we show, using methods optimized specifically for the midbrain (including high‐resolution imaging, a novel registration protocol, and physiological noise modelling), a BOLD (blood‐oxygen‐level dependent) signal to both financial gain and loss in the VTA and SNC, along with a response to nil outcomes that are better or worse than expected in the VTA. Taken together, these findings suggest that the human VTA and SNC are involved in the processing of both appetitive and aversive financial outcomes in humans. [ABSTRACT FROM AUTHOR]

Objects that promise rewards are prioritized for visual selection. The way this prioritization shapes sensory processing in visual cortex, however, is debated. It has been suggested that rewards motivate stronger attentional focusing, resulting in a modulation of sensory selection in early visual cortex. An open question is whether those reward-driven modulations would be independent of similar modulations indexing the selection of attended features that are not associated with reward. Here, we use magnetoencephalography in human observers to investigate whether the modulations indexing global color-based selection in visual cortex are separable for target- and (monetary) reward-defining colors. To assess the underlying global color-based activity modulation, we compare the event-related magnetic field response elicited by a color probe in the unattended hemifield drawn either in the target color, the reward color, both colors, or a neutral task-irrelevant color. To test whether target and reward relevance trigger separable modulations, we manipulate attention demands on target selection while keeping reward-defining experimental parameters constant. Replicating previous observations, we find that reward and target relevance produce almost indistinguishable gain modulations in ventral extratriate cortex contralateral to the unattended color probe. Importantly, increasing attention demands on target discrimination increases the response to the target-defining color, whereas the response to the rewarded color remains largely unchanged. These observations indicate that, although task relevance and reward influence the very same feature-selective area in extrastriate visual cortex, the associated modulations are largely independent. [ABSTRACT FROM AUTHOR]

We prove the equivalence of two presentations of the Yangian Y(g) of a simple Lie algebra g, and we also show the equivalence with a third presentation when g is either an orthogonal or a symplectic Lie algebra. As an application, we obtain an explicit correspondence between two versions of the classification theorem of finite-dimensional irreducible modules for orthogonal and symplectic Yangians. [ABSTRACT FROM AUTHOR]

We introduce a new family of thermostat flows on the unit tangent bundle of an oriented Riemannian two-manifold. Suitably reparametrised, these flows include the geodesic flow of metrics of negative Gauss curvature and the geodesic flow induced by the Hilbert metric on the quotient surface of divisible convex sets. We show that the family of flows can be parametrised in terms of certain weighted holomorphic differentials and investigate their properties. In particular, we prove that they admit a dominated splitting and we identify special cases in which the flows are Anosov. In the latter case, we study when they admit an invariant measure in the Lebesgue class and the regularity of the weak foliations. [ABSTRACT FROM AUTHOR]

This review is focused on planar chromatography hyphenated with mass‐spectrometric detection for analysis of low‐molecular‐mass solutes. Various kinds of hyphenations are discussed with attention paid to the preparation of thin layer plates suited both for the mass‐spectrometric detection of the resolved solutes direct from thin‐layer plates and for indirect mass‐spectrometric detection of the resolved solutes, performed by scraping, extracting, purifying, and concentrating the analyte from the thin‐layer chromatography plate. Plates with monolithic layers are relatively new for thin‐layer chromatography but they can successfully be combined with mass‐spectrometric technique in a pursuit of comprehensive local sample composition information. Preparation of monolithic layers of different porosity and structure based on organic, inorganic, and composite materials is illustrated together with examples of successful separation and detection of low‐molecular‐mass solutes by means of matrix‐assisted and surface‐assisted laser desorption mass spectrometry. [ABSTRACT FROM AUTHOR]

Metabolite-protein interactions define the output of metabolic pathways and regulate many cellular processes. Although diseases are often characterized by distortions in metabolic processes, efficient means to discover and study such interactions directly in cells have been lacking. A stringent implementation of proteome-wide Cellular Thermal Shift Assay (CETSA) was developed and applied to key cellular nucleotides, where previously experimentally confirmed protein-nucleotide interactions were well recaptured. Many predicted, but never experimentally confirmed, as well as novel protein-nucleotide interactions were discovered. Interactions included a range of different protein families where nucleotides serve as substrates, products, co-factors or regulators. In cells exposed to thymidine, a limiting precursor for DNA synthesis, both dose- and time-dependence of the intracellular binding events for sequentially generated thymidine metabolites were revealed. Interactions included known cancer targets in deoxyribonucleotide metabolism as well as novel interacting proteins. This stringent CETSA based strategy will be applicable for a wide range of metabolites and will therefore greatly facilitate the discovery and studies of interactions and specificities of the many metabolites in human cells that remain uncharacterized. [ABSTRACT FROM AUTHOR]

In this work, we provide the first generalized and critical analysis of data on the chemistry of malononitrile dimer (2-aminopropene-1,1,3-tricarbonitrile) - a multifunctional reagent that is widely used for the preparation of diverse heterocyclic systems. The majority of references are from the last 20-25 years. [ABSTRACT FROM AUTHOR]

The article evaluates the effect of pulsed-high-voltage energization upon three types of cylindrical electrostatic precipitators that might be installed on the exhaust pipe of household boilers. The three models are similar in that the corona discharge is generated between a thin copper wire (diameter 0.16 mm), coaxial with a 354 mm long aluminum cylinder (inner diameter: 40 mm) that is the collecting electrode. The first model is a "standard" constant cross-section precipitator. The other two models are characterized by the presence of a 17 mm long, reduced cross-section (diameter: 23 or 30 mm) intermediate sector, located at about 1/3 of the precipitator length, from the inlet. The reduced cross-section was achieved by a sleeve made of either aluminum or polyvinylchloride, so that to create, in the latter case, a dielectric-barrier discharge. Pulsed energization of the three models of electrostatic precipitators was provided by positive or negative DC high-voltage supplies and a mechanical rotary spark-gap. The frequency of the high-voltage pulses ranged between 120 and 280 Hz. The experimental results show that the collection efficiency was better for both negative and positive high-voltage pulses. The best collection performances were obtained with the hybrid corona and dielectric-barrier discharge precipitator. [ABSTRACT FROM AUTHOR]

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

We introduce two Hopf algebroids associated to a proper and holomorphic Lie group action on a complex manifold. We prove that the cyclic cohomology of each Hopf algebroid is equal to the Dolbeault cohomology of invariant differential forms. When the action is cocompact, we develop a generalized complex Hodge theory for the Dolbeault cohomology of invariant differential forms. We prove that every cyclic cohomology class of these two Hopf algebroids can be represented by a generalized harmonic form. This implies that the space of cyclic cohomology of each Hopf algebroid is finite dimensional. As an application of the techniques developed in this paper, we generalize the Serre duality and prove a Kodaira type vanishing theorem. [ABSTRACT FROM AUTHOR]

Summary: We evaluated the association of Human Pegivirus (HPgV) viraemia with risk of developing lymphoma, overall and by major subtypes. Because this virus has also been associated with better prognosis in the setting of co‐infection with human immunodeficiency virus, we further assessed the association of HPgV with prognosis. We used risk factor data and banked plasma samples from 2094 lymphoma cases newly diagnosed between 2002 and 2009 and 1572 frequency‐matched controls. Plasma samples were tested for HPgV RNA by reverse transcription polymerase chain reaction (RT‐PCR), and those with RNA concentrations <5000 genome equivalents/ml were confirmed using nested RT‐PCR methods. To assess the role of HPgV in lymphoma prognosis, we used 2948 cases from a cohort study of newly diagnosed lymphoma patients (included all cases from the case‐control study). There was a positive association of HPgV viraemia with risk of lymphoma overall (Odds ratio = 2·14; 95% confidence interval [CI] 1·63–2·80; P < 0·0001), and for all major subtypes except Hodgkin lymphoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma, and this was not confounded by other lymphoma risk factors. In contrast, there was no association of HPgV viraemia with event‐free survival (Hazard ratio [HR] = 1·00; 95% CI 0·85–1·18) or overall survival (HR = 0·97; 95% CI 0·79–1·20) for lymphoma overall, or any of the subtypes. These data support the hypothesis for a role of HPgV in the aetiology of multiple lymphoma subtypes. [ABSTRACT FROM AUTHOR]

Introduction: To expedite the process of treatment, recovery of patients and prevention of medical adverse effects, dentists should be aware of prescription errors. This study aimed to investigate prescription behavior of dentists and common prescription errors by dentists in Razavi Khorasan Province. Materials & Methods: In this study, 1108 prescriptions by dentists in Razavi Khorasan Province from Fenruary 2016 to July 2016, from Social Security and Therapeutic Services insurance organizations were evaluated. To collect data, a list was prepared, consisting of drug forms, drug names, drug doses, intervals of administration, route of administration, drug interferences and the number of items in each prescription. Furthermore, the lack of date, dentist’s signature or seal, and illegibility of the prescription were recorded in the error list of the prescription. Data were analyzed using chi-squared and Fisher’s exact tests. Results: Most errors were related to incorrect drug form (17.3%), incorrect route of administration (10.9%) and incorrect dose (10.4%). The mean number of medications prescribed per patient was 2.36. Antibiotics (50.7%) and antiinflammatory drugs (33.5%) were respectively the most commonly prescribed medications. Conclusion: The results of the present study demonstrated that the performance of dentists in Razavi Khorasan Province was appropriate in terms of the number of drugs prescribed per patient; however, the number of prescribed antibiotics and nonsteroidal antiinflammatory drugs was higher than the reports in other countries. Given the high percentage of errors in prescriptions, it is highly recommended that the prescription behavior be included in the curricula of dentistry and be emphasized in continuous education programs for dentists. [ABSTRACT FROM AUTHOR]

This review is the eighth update of the original article published in 1999 on the application of Matrix‐assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2014. Topics covered in the first part of the review include general aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, fragmentation, and arrays. The second part of the review is devoted to applications to various structural types such as oligo‐ and poly‐ saccharides, glycoproteins, glycolipids, glycosides, and biopharmaceuticals. Much of this material is presented in tabular form. The third part of the review covers medical and industrial applications of the technique, studies of enzyme reactions, and applications to chemical synthesis. © 2018 Wiley Periodicals, Inc. Mass Spec Rev 37:353–491, 2018. [ABSTRACT FROM AUTHOR]

We provide a very brief review of the description of colored invariants for the Hopf link in terms of characters, which need to be taken at a peculiar deformation of the topological locus, depending on one of the two representations associated with the two components of the link. Most important, we extend the description of this locus to conjugate and, generically, to composite representations and also define the “adjoint” Schur functions emerging in the dual description. [ABSTRACT FROM AUTHOR]

Aims: In patients with atrial fibrillation, catheter ablation and cardioversion carry a risk of peri-procedural thromboembolic events; current guidelines recommend anticoagulation in these settings. This study aimed to report the baseline demographics and clinical characteristics of patients enrolled in the prospective, observational XANTUS study who underwent catheter ablation or cardioversion, and adverse outcomes with each of these procedures in patients treated with rivaroxaban.Methods and results: Data collected included information on catheter ablation and cardioversion, and adverse outcomes occurring within 30 days of these procedures: incidence of treatment-emergent adjudicated symptomatic thromboembolic events and major bleeding; and cardiovascular and all-cause death. Incidence of these adverse outcomes at 42 days after cardioversion was also analysed. Patients undergoing either procedure had significantly lower mean CHA2DS2-VASc and HAS-BLED scores than those who did not, and were more frequently hospitalized at study baseline. Within a period of 30 days after intervention, symptomatic thromboembolic events were reported in 1.2% and 0.6% of patients undergoing ablation or cardioversion, respectively; major bleeding events were reported in 2.9% and 0.4% of patients undergoing ablation or cardioversion, respectively. No patients died within 30 days of intervention. Incidence of symptomatic thromboembolic and major bleeding events remained low at 42 days after cardioversion.Conclusion: Similar to the results of prospective and non-interventional studies, the low rates of symptomatic thromboembolic events and major bleeding in patients with atrial fibrillation undergoing ablation or cardioversion and treated with rivaroxaban in XANTUS suggest that its use is associated with an acceptable benefit-risk profile in this setting.Trial registration number: Clinicaltrials.gov: NCT01606995. [ABSTRACT FROM AUTHOR]

When the so-called eek effect emerges while shifting a vehicle shift gearbox, car drivers perceive audible noise and vibrations of drivetrain components. Some physical approaches have been provided in order to explain the effect as well as to search for countermeasures. In Jehle and Fidlin (ZAMM J Appl Math Mech 94(11):911-916 (2014), the interaction of sliding clutch disk and gears is addressed in a rigid body model. The clutch disk’s non-conservative follower forces in combination with geometric coupling in gears imply the action of non-symmetric restoring- and velocity-proportional forces. The desired motion of gearbox components can therefore undergo a mode-coupling flutter instability, out of which vibrations emerge with exponentially growing amplitudes. As the contacts in clutch and gears hold non-smooth transitions such as the possibility of sticking and opening, dynamic solutions are both limited and complex. In this contribution, first of all model details concerning the gear formulation are revised: rigid and viscoelastic normal contact are compared, which imply differences in the nature of the solution and method of stability analysis. Nevertheless the two approaches are shown to converge. Finally, the dynamics behind the loss of stability of the desired motion is investigated. [ABSTRACT FROM AUTHOR]

Copyright of Review of Medicine / Przeglad Lekarski is the property of Wydawnictwo Przegld Lekarski / Publisher Medicine Review and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The area of reaction mechanism discovery simulation has taken considerable strides in recent years. Novel methods that make hypotheses for elementary steps and complementary means for reaction path and transition state (TS) optimization are lowering the amount of chemical intuition and user effort required to explore reaction networks. The resulting networks lead from reactants to reactive intermediates and products, and are becoming closer representations of physical mechanisms involved in experiments. This review describes several of these approaches, which are categorized based on their overarching TS finding strategies. Future advances are discussed that may revolutionize the ability of simulation to fully predict not just the reaction mechanism but reaction outcomes. WIREs Comput Mol Sci 2018, 8:e1354. doi: 10.1002/wcms.1354 This article is categorized under: Structure and Mechanism > Reaction Mechanisms and Catalysis Software > Quantum Chemistry Software > Simulation Methods [ABSTRACT FROM AUTHOR]

The stabilization height of a fiber surface in the 3-sphere is the minimal number of Hopf plumbing operations needed to attain a stable fiber surface from the initial surface. We show that families of fiber surfaces related by iterated Stallings twists have unbounded stabilization height. [ABSTRACT FROM AUTHOR]

In this paper, we investigate hypergroups which arise from association schemes in a canonical way; this class of hypergroups is called realizable. We first study basic algebraic properties of realizable hypergroups. Then we prove that two interesting classes of hypergroups (partition hypergroups and linearly ordered hypergroups) are realizable. Along the way, we prove that a certain class of projective geometries is equipped with a canonical association scheme structure which allows us to link three objects; association schemes, hypergroups, and projective geometries (see, Section 1.2 for details). [ABSTRACT FROM AUTHOR]

Cell-based assays for compound screening and profiling are fundamentally important in life sciences, chemical biology and pharmaceutical research. Most cell assays measure the amount of a single reporter molecule or cellular endpoint, and require the use of fluorescence or other labeled materials. Consequently, there is high demand for label-free technologies that enable multiple biomolecules or endpoints to be measured simultaneously. Here, we describe how to develop, optimize and validate MALDI-TOF mass spectrometry (MS) cell assays that can be used to measure cellular uptake of transporter substrates, to monitor cellular drug target engagement or to discover cellular drug-response markers. In uptake assays, intracellular accumulation of a transporter substrate and its inhibition by test compounds is measured. In drug response assays, changes to multiple cellular metabolites or to abundant posttranslational protein modifications are monitored as reporters of drug activity. We detail a ten-part optimization protocol with every part taking 1-2 d that leads to a final 2 d optimized procedure, which includes cell treatment, transfer, MALDI MS-specific sample preparation, quantification using stable-isotope-labeled standards, MALDI-TOF MS data acquisition, data processing and analysis. Key considerations for validation and automation of MALDI-TOF MS cell assays are outlined. Overall, label-free MS cell-based assays offer speed, sensitivity, accuracy and versatility in drug research., (© 2021. The Author(s), under exclusive licence to Springer Nature Limited.)

Purpose: This study aims to validate major bleeding (MB) cases within a cohort of new users of direct oral anticoagulants (DOACs) in Electronic health records (EHRs) from primary care in Spain (BIFAP), introducing more efficient techniques and automating the process of validation in the pharmacoepidemiologic research with EHR data as much as possible., Methods: Registered bleedings were identified in a cohort of new users of DOACs in BIFAP using ICPC 2 and ICD 9 codes; we ascertained these bleedings as MB through a validation strategy based on the MB definition from the International Society on Thrombosis and Hemostasis, which used hospitalization and critical localization as proxies. We assessed hospitalization with hospital discharge information (only available for some years and regions) and a free text-based algorithm created to identify hospitalization in EHR's clinical notes. Incidence rates (IR) of MB were evaluated by bleeding type., Results: The study cohort included 104 614 patients, with 274521.5 p-y of follow up. There were 6143 registered bleedings during the study period (519 intracranial bleeding - ICB, 4606 gastrointestinal bleeding - GIB, 1018 extracranial bleeding - ECB), from which 1679 were confirmed as MB (416 ICB, 1086 GIB, and 177 ECB). The free text-based semi-automatic algorithm had moderate recall (0.59), but high specificity (0.99), and precision (0.94)., Conclusion: The combination of hospitalization and critical localization is a valid approach to validate MB in EHRs with incomplete information. The use of more automatic methods for case validation instead of manual review of clinical notes is favored., (© 2021 John Wiley & Sons Ltd.)

Abstract: Lipids, which have a core function in energy storage, signalling and biofilm structures, play important roles in a variety of cellular processes because of the great diversity of their structural and physiochemical properties. Lipidomics is the large‐scale profiling and quantification of biogenic lipid molecules, the comprehensive study of their pathways and the interpretation of their physiological significance based on analytical chemistry and statistical analysis. Lipidomics will not only provide insight into the physiological functions of lipid molecules but will also provide an approach to discovering important biomarkers for diagnosis or treatment of human diseases. Mass‐spectrometry‐based analytical techniques are currently the most widely used and most effective tools for lipid profiling and quantification. In this review, the field of mass‐spectrometry‐based lipidomics was discussed. Recent progress in all essential steps in lipidomics was carefully discussed in this review, including lipid extraction strategies, separation techniques and mass‐spectrometry‐based analytical and quantitative methods in lipidomics. We also focused on novel resolution strategies for difficult problems in determining C=C bond positions in lipidomics. Finally, new technologies that were developed in recent years including single‐cell lipidomics, flux‐based lipidomics and multiomics technologies were also reviewed. [ABSTRACT FROM AUTHOR]

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and it leads to significant morbidity and mortality, predominantly from ischemic stroke. Vitamin K antagonists, mainly warfarin, have been used for decades to prevent ischemic stroke in AF, but their use is limited due to interactions with food and other drugs, as well as the requirement for regular monitoring of the international normalized ratio. Rivaroxaban, a direct factor Xa inhibitor and the most commonly used non-vitamin K oral anticoagulant, avoids many of these challenges and is being prescribed with increasing frequency for stroke prevention in non-valvular AF. Randomized controlled trial (RCT) data from the ROCKET-AF(Rivaroxaban once daily oral direct Factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation) trial have shown rivaroxaban to be non-inferior to warfarin in preventing ischemic stroke and systemic embolism and to have comparable overall bleeding rates. Applicability of the RCT data to real-world practice can sometimes be limited by complex clinical scenarios or multiple comorbidities not adequately represented in the trials. Available real-world evidence in non-valvular AF patients with comorbidities - including renal impairment, acute coronary syndrome, diabetes mellitus, malignancy, or old age - supports the use of rivaroxaban as safe and effective in preventing ischemic stroke in these subgroups, though with some important considerations required to reduce bleeding risk. Patient perspectives on rivaroxaban use are also considered. Real-world evidence indicates superior rates of drug adherence with rivaroxaban when compared with vitamin K antagonists and with alternative non-vitamin K oral anticoagulants - perhaps, in part, due to its once-daily dosing regimen. Furthermore, self-reported quality of life scores are highest among patients compliant with rivaroxaban therapy. The generally high levels of patient satisfaction with rivaroxaban therapy contribute to overall favorable clinical outcomes. [ABSTRACT FROM AUTHOR]

Families of vector-like deformed relativistic quantum phase spaces and corresponding realizations are analyzed. A method for a general construction of the star product is presented. The corresponding twist, expressed in terms of phase space coordinates, in the Hopf algebroid sense is presented. General linear realizations are considered and corresponding twists, in terms of momenta and Poincaré-Weyl generators or $$\mathfrak {gl}(n)$$ generators are constructed and R-matrix is discussed. A classification of linear realizations leading to vector-like deformed phase spaces is given. There are three types of spaces: (i) commutative spaces, (ii) $$\kappa $$ -Minkowski spaces and (iii) $$\kappa $$ -Snyder spaces. The corresponding star products are (i) associative and commutative (but non-local), (ii) associative and non-commutative and (iii) non-associative and non-commutative, respectively. Twisted symmetry algebras are considered. Transposed twists and left-right dual algebras are presented. Finally, some physical applications are discussed. [ABSTRACT FROM AUTHOR]

Background: Non-vitamin K dependent oral anticoagulants (NOACs) significantly decrease overall major bleeding rates compared with vitamin K antagonists (VKAs) but there is conflicting evidence regarding the relative risk of gastrointestinal bleeding. Since data regarding the types, the management, and the outcome of NOAC-associated gastrointestinal bleeding are scarce, we aimed to fill this gap by comparing cases of gastrointestinal bleeding associated with NOAC, VKA, or antiplatelet therapy.Methods: All major gastrointestinal bleeding events documented in the prospective Dresden NOAC registry were identified, and bleeding location, lesion type, endoscopic treatment, use of blood and coagulation factor transfusion, length of stay, and in-hospital mortality were compared with historical data from a large cohort of consecutive gastrointestinal bleeding patients.Results: In the 143 NOAC therapy cases, upper gastrointestinal tract bleeding was seen in 44.1%, lower gastrointestinal tract bleeding was seen in 42.0%, and no lesion could be identified in the remaining 14.0%. In contrast, upper gastrointestinal tract bleeding was commoner in the 185 VKA therapy cases (53.0%) and in the 711 antiplatelet therapy cases (68.1%). Among cases with upper gastrointestinal tract bleeding during VKA or antiplatelet therapy, 54.1% and 61.4% respectively presented with ulcers, compared with 27.0% for NOAC therapy. In contrast, hemorrhoid bleeding was the predominant lesion type for lower gastrointestinal tract bleeding with NOAC therapy, with a rate of 33.3%, compared with 10.6% with VKA therapy and 8.7% with antiplatelet therapy. NOAC-associated gastrointestinal bleeding resulted in comparatively low resource consumption, shorter hospitalization, and low in-hospital mortality (1.6%) compared with gastrointestinal bleeding historically seen with use of VKAs (in-hospital mortality 5.6%) or antiplatelet agents (in-hospital mortality 11.9%).Conclusions: Gastrointestinal bleeding in NOAC recipients is different from that seen with VKA or antiplatelet therapy and has a better short-term prognosis. [ABSTRACT FROM AUTHOR]

This paper analyzes the existence of Hopf bifurcation and establishes the conditions under which the equilibrium path converges toward periodic solutions in a one-sector optimal growth model with delay. We establish the limits and the possibilities of nonlinear dynamics (i.e., cycles) vis-à-vis delays. In particular, we formulate a new method to further comprehend the root distribution of the characteristic equation of a standard optimal growth model with delayed investment structure. We show that nonmonotonic dynamics (limit cycles, persistent oscillations) occurs when the delayed investment causes permanent adjustment failures among the economic variables in the economy. [ABSTRACT FROM AUTHOR]

We introduce Hopf polyads in order to unify Hopf monads and group actions on monoidal categories. A polyad is a lax functor from a small category (its source) to the bicategory of categories, and a Hopf polyad is a comonoidal polyad whose fusion operators are invertible. The main result states that the normalization of a Hopf polyad is a strong (co)monoidal action-type polyad (or strong monoidal pseudofunctor). The normalization of a polyad is a new polyad having simpler structure but the same category of modules. We show that, under certain assumptions, a Hopf polyad can be 'wrapped up' into a Hopf monad. This generalizes the fact that finite group actions on tensor categories can be seen as Hopf monads. Hopf categories in the sense of Batista, Caenepeel and Vercruysse can be viewed as Hopf polyads in a braided setting via the notion of Hopf polyalgebras. As a special case of the main theorem, we generalize a description of the center of graded fusion category due to Turaev and Virelizier to tensor categories: if $\mathcal {C}$ is a G-graded (locally bounded) tensor category, then G acts on the relative center of $\mathcal {C}$ with respect to the degree one part $\mathcal {C}_{1}$ , and the equivariantization of this action is the center of $\mathcal {C}$ . [ABSTRACT FROM AUTHOR]

We introduce the generalized twisted $$\Gamma \times \mathbb {T}^{n}$$ -equivariant degree with n free parameters, where $$\Gamma $$ is a nonabelian finite group, present a computational formulae based on the reduction to $$\mathbb {T}^{n}$$ -equivariant maps and reduction of parameters techniques. This twisted equivariant degree can be effectively applied to study Hopf bifurcation with symmetries from relative equilibria. We give an example of such bifurcation in a system of ODEs. [ABSTRACT FROM AUTHOR]

This study focused on the potential toxicity of silver nanoparticles (AgNPs) on cardiac electrophysiology which is rarely investigated. We found that AgNPs (10−9–10−6 g/ml) concentration-dependently depolarized the resting potential, diminished the action potential, and finally led to loss of excitability in mice cardiac papillary muscle cellsin vitro. In cultured neonatal mice cardiomyocytes, AgNPs (10−9–10−7 g/ml) concentration-dependently decreased the Na+currents (INa), accelerated the activation, and delayed the inactivation and recovery of Na+channels from inactivation within 5 min. AgNPs at 10−8 g/ml also rapidly decreased the inwardly rectifying K+currents (IK1) and delayed the activation ofIK1channels. Intravenous injection of AgNPs at 3 mg/kg only decreased the heart rate, while at ≥4 mg/kg sequentially induced sinus bradycardia, complete atrio-ventricular conduction block, and cardiac asystole. AgNPs at 10−10–10−6 g/ml did not increase reactive oxygen species (ROS) generation and only at 10−6 g/ml mildly induced lactate dehydrogenase (LDH) release in the cardiomyocytes within 5 min. Endocytosis of AgNPs by cardiomyocytes was not observed within 5 min, but was observed 1 h after exposing to AgNPs. Comparative Ag+(≤0.02% of the AgNPs) could not induce above toxicities. We conclude that AgNPs exert rapid toxic effects on myocardial electrophysiology and induce lethal bradyarrhythmias. These acute toxicities are likely due to direct effects of AgNPs on ion channels at the nano-scale level, but not caused by Ag+, ROS, and membrane injury. These findings provide warning to the nanomedical practice using AgNPs. [ABSTRACT FROM PUBLISHER]

We introduce a family of braided Hopf algebras that (in characteristic zero) generalizes the rank 1 Hopf algebras introduced by Krop and Radford and we study its cleft extensions. [ABSTRACT FROM PUBLISHER]

The present study examines the hydrogen peroxide scavenging, anticoagulant and thrombolytic activities of silver nanoparticles (AgNPs) that were biosynthesized using extracts obtained from spider cobweb (CB), pod (KP), seed (KS) and seed shell (KSS) of kolanut ( Cola nitida). The nearly spherical shaped AgNPs, with surface plasmon resonance of 431.5-457.5 nm, were polydispersed having sizes of 3-50, 12-80, 8-50, and 5-40 nm for CB, KP, KS and KSS-AgNPs respectively. Hydrogen peroxide scavenging activities of 77-99.8% were obtained using 1-20 µg/ml of AgNPs. The particles prevented the coagulation of blood, and also showed thrombolytic activities of 55.76-89.83%, with KSS-AgNPs having the highest activity. Microscopic examination of the lyzed blood clot supported the thrombolytic activities. On the other hand, silver nitrate solution showed negligible activity of 1.92%, while thrombolysis of 7.55, 8.70, 8.93 and 30.19% were obtained for the extracts of KSS, CB, KS and KP respectively. The results herein presented showed potential biomedical applications of the biosynthesized AgNPs to scavenge free radicals and for the management of blood coagulation disorders and thrombotic diseases. [ABSTRACT FROM AUTHOR]

Complex materials are ubiquitous in science, engineering and nature. One important parameter for characterising their morphology is the degree of anisotropy. Magnetic resonance imaging offers non-invasive methods for quantitative measurements of the materials anisotropy, most commonly via diffusion tensor imaging and the subsequent extraction of the spatially resolved fractional anisotropy (FA) value. Here, we propose an alternative way of determining the FA as a sample average for cases where spatially resolved methods are not needed or not applicable. It is based on a particular diffusion-diffusion correlation spectroscopy protocol, allowing for the extraction of the mean (i.e. sample averaged) FA value. We demonstrate that mean FA values obtained from three anisotropic biological tissues are consistent with those extracted using diffusion tensor imaging. Moreover, we show that differences of mean FA values in healthy and tumour-bearing mouse brains allow to distinguish these tissue types. We anticipate that the proposed method will be beneficial in the wider context of medical and material science. [ABSTRACT FROM AUTHOR]

A depth-first search version of Dhar's burning algorithm is used to give a bijection between the parking functions of a graph and labeled spanning trees, relating the degree of the parking function with the number of inversions of the spanning tree. Specializing to the complete graph solves a problem posed by R. Stanley. [ABSTRACT FROM AUTHOR]

Background: Rivaroxaban is a member of the novel targetspecific oral anticoagulants (TSOACs) family of drugs recently approved for the prevention and treatment of venous thromboembolism events. A major drawback of the drug is its potential for causing severe hemorrhagic events, which may be difficult to treat in an emergency setting due to lack of effective antidote. Here, we describe a case of acute gastrointestinal (GI) hemorrhage leading to complete colon obstruction in a patient treated with rivaroxaban. Summary and Key Messages: The case presented here demonstrates a chain of events originating from an unprovoked intramural bleeding in a patient using rivaroxaban, leading to an organized giant clot formation, and to complete colon obstruction. In the available literature, the specific site of the GI bleeding has not been discussed. A further study is recommended and re-examination of bleeding events and exploration of new cases due to the use of TSOACs can help predict the course and the outcomes of such complications. [ABSTRACT FROM AUTHOR]

Cheri Pearce, runner up at the BJN Awards 2019, describes the work she and her team did to be shortlsted [ABSTRACT FROM AUTHOR]

It is crucial for humans to coordinate between behavioural tendencies that can lead to reward but are in conflict with each other. This response conflict can be measured in a reward-modulated Simon task, in which a discriminative response to the identity of a lateral target is required and the target is associated with either high- or low-reward. Critically, the lateral target is presented either congruent or incongruent with the location of the responding hand. It has been shown that relative to the low-reward target, the high-reward target induced a larger response conflict when the target was incongruent with the position of the task-required, reward-obtaining hand. Here we investigated how this response conflict is resolved by acquiring 24 healthy participants' electromyography (EMG) signals from both the task-required responding hand (i.e., goal-directed effector) and the alternative hand (i.e., inappropriate effector). During the coping with the response conflict, motor inhibition (indexed by reduction in EMG signals between conditions) was observed not only at the inappropriate effector but also at the goal-directed effector. Individuals who showed stronger inhibition on the inappropriate effector suffered less from the inhibition on the goal-directed effector, and had more efficient implementation of the reward-obtaining response. Our findings suggest a global motor inhibition that may function to increase the signal-noise ratio in the motor system so as to implement reward-guided behavior., (© 2021 Society for Psychophysiological Research.)

We introduce a novel harmonic superspace for $${3d \mathcal{N}=6}$$ superconformal field theories that is tailor made for the study of correlation functions of BPS operators. We calculate a host of two- and three-point functions in full generality and put strong constraints on the form of four-point functions of some selected BPS multiplets. For the four-point function of $${\frac{1}{2}}$$ -BPS operators we obtain the associated Ward identities by imposing the absence of harmonic singularities. The latter imply the existence of a solvable subsector in which the correlator becomes topological. This mechanism can be explained by cohomological reduction with respect to a special nilpotent supercharge. [ABSTRACT FROM AUTHOR]