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646 results on '"Muller, I"'

211. Basic research and clinical applications of non-hematopoietic stem cells, 4-5 April 2008, Tubingen, Germany.

Author

Schäfer, R., Dominici, M., Muller, I., Horwitz, E., Asahara, T., Bulte, J. W. M., Bieback, K., Le Blanc, K., Bühring, H. J., Capogrossi, M. C., Dazzi, F., Gorodetsky, R., Henschler, R., Handgretinger, R., Kajstura, J., Kluger, P. J., Lange, C., von Luettichau, I., Mertsching, H., and Schrezenmeier, H.

Subjects
HEMATOPOIETIC stem cells, MEDICAL imaging systems, CANCER treatment, BLOOD cells
Abstract

From 4 to 5 April 2008, international experts met for the second time in Tubingen, Germany, to present and discuss the latest proceedings in research on non-hematopoietic stem cells (NHSC). This report presents issues of basic research including characterization, isolation, good manufacturing practice (GMP)-like production and imaging as well as clinical applications focusing on the regenerative and immunomodulatory capacities of NHSC. [ABSTRACT FROM AUTHOR]

Published
2009
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213. Pre-harvest application of soybean oil alters epicuticular wax crystallisation patterns and resistance to weight loss in `Golden Delicious' apples during storage.

Author

Muller, I. and Fellman, J. K.

Subjects
APPLES, SOY oil, CRYSTALLIZATION, FRUIT storage
Abstract

The effect of field-applied soybean oil emulsion on weight loss during storage, development of cuticular cracks, and epicuticular wax crystallisation patterns in apples was studied using three orchard locations in Washington State, USA. Three single treatments (mid-season, 21 d before harvest, and 3 d before harvest) of soybean oil emulsion [1% (v/v) food grade soybean oil; 0.1% (v/v) emulsifier Latron B-1956®] were administered to 'Golden Delicious' apples. Apples were harvested at commercial maturity and stored for up to 180 d at 0.5°C in refrigerated air or under controlled atmosphere storage conditions (2 kPa O2 and 0.2 kPa CO2). The rate of weight loss decreased in all soybean oil-treated apples. Orchard location and humidity conditions during storage also influenced the amount of weight loss seen for all oil-treatment timings. As observed by scanning electron microscopy, 'Golden Delicious' apples developed cracks that intensified with maturity. Crack development was also influenced by orchard location. Pre-harvest application of soybean oil emulsion decreased the occurrence and severity of cuticular cracks in susceptible cultivars such as 'Golden Delicious', with treatments applied closer to harvest being most beneficial. The rate of weight loss during storage was directly related to the development of cracks. All apples showed altered wax crystallisation patterns after the application of soybean oil. [ABSTRACT FROM AUTHOR]

Published
2007

217. Acalypha purpurascens

Author

C. Muller & I. Johnston, C. Muller & I. Johnston, C. Muller & I. Johnston, and C. Muller & I. Johnston

Abstract

Angiosperms, http://name.umdl.umich.edu/IC-HERB00IC-X-1156743%5DMICH-V-1156743, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1156743/MICH-V-1156743/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Published
1940

218. Commissioning of the Metrology Light Source.

Author

Abo-Bakr, M., Birke, T., Borninkhof, J., Budz, P., Burkmann-Gehrlein, K., Daum, R., Dressler, O., Durr, V., Falkenstern, F., Feikes, J., Glass, H., Hoberg, H.G., Kolbe, J., Kuszynski, J., Lange, R., Muller, I., Muller, R., Rahn, J., Schindhelm, G., and Schneegans, T.

Published
2007
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226. Application of Cell Culture for the Production of Bioactive Compounds from Sponges:  Synthesis of Avarol by Primmorphs from Dysidea avara

Author

Muller, W. E. G., Bohm, M., Batel, R., Rosa, S. De, Tommonaro, G., Muller, I. M., and Schroder, H. C.

Abstract

Among all metazoan phyla, sponges are known to produce the largest number of bioactive compounds. However, until now, only one compound, arabinofuranosyladenine, has been approved for application in humans. One major obstacle is the limited availability of larger quantities of defined sponge starting material. Recently, we introduced the in vitro culture of primmorphs from Suberites domuncula, which contain proliferating cells. Now we have established the primmorph culture also from the marine sponge Dysidea avara and demonstrate that this special form of sponge cell aggregates produces avarol, a sesquiterpenoid hydroquinone, known to display strong cytostatic activity especially against mammalian cells. If dissociated sponge cells are transferred into Ca2+- and Mg2+-containing seawater, they form after a period of two to three days round-shaped primmorphs (size of 1 to 3 mm). After longer incubation, the globular primmorphs fuse and form meshes of primmorphs that adhere to the bottom of the incubation chamber. Later, during incubation, freely floating mesh-primmorphs are formed. No bacterial rRNA could be detected in the primmorphs. We were able to prove that the primmorphs produce avarol. Levels (1.4 μg of avarol/100 μg of protein) close to those identified in specimens from the field (1.8 μg/100 μg) are reached. Avarol was extracted from the cells with EtOAc and subsequently purified by HPLC. The identification was performed spectrophotometrically and by thin-layer chromatography. Single cells apparently do not have the potency to produce this secondary metabolite. It is concluded that the primmorph model is a suitable system for the synthesis of bioactive compounds in vitro.

Published
2000

239. X-ray structure determination of a chiral synthon, essential for the synthesis of 25-2H-stigmasterol

Author

Marsan, M. P., Muller, I., Milon, A., Warnock, W., Nakatani, Y., Ourisson, G., and Jaud, J.

Abstract

Synthesis of sterols with varying side chains, including deuterium labeled stigmasterol and sitosterol may be performed via the Wittig-Horner coupling of a 22 aldehyde derived from stigmasterol and a suitable sulfoxide derivative of the side chain. The X-ray structure determination of this synthon have been performed since it is a crucial step in order to know the absolute configuration of the chiral carbon atoms. Crystallographic data were as follows:a=7.437(2),b=10.103(4),c=10.274(3)Å, ß=100.32(6)o,=759.4 Å3, space group P21 (No.4),Z=2,Dc=1.239 g cm-3.

Published
1995
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