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3,020 results on '"Muñoz L."'

202. Daily tenofovir disoproxil fumarate/emtricitabine and hydroxychloroquine for pre-exposure prophylaxis of COVID-19: a double-blind placebo controlled randomized trial in healthcare workers

Author

Polo, R, primary, García-Albéniz, X, additional, Terán, C, additional, Morales, M, additional, Rial-Crestelo, D, additional, Garcinuño, MA, additional, García del Toro, M, additional, Hita, C, additional, Gómez-Sirvent, JL, additional, Buzón, L, additional, Díaz de Santiago, A, additional, Pérez Arellano, JL, additional, Sanz, J, additional, Bachiller, P, additional, Martínez Alfaro, E, additional, Díaz-Brito, V, additional, Masiá, M, additional, Hernández-Torres, A, additional, Guerra, J, additional, Santos, J, additional, Arazo, P, additional, Muñoz, L, additional, Arribas, JR, additional, Martínez de Salazar, P, additional, Moreno, S, additional, Hernán, MA, additional, and Del Amo, J, additional

Published
2022
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204. Differential levels of Neurofilament Light protein in cerebrospinal fluid in patients with a wide range of neurodegenerative disorders

Author

Delaby, Constance, Alcolea, Daniel, Carmona Iragui, María, Illán-Gala, Ignacio, Morenas Rodríguez, Estrella, Barroeta, Isabel, Altuna-Azkargorta, Miren, Estellés, T., Santos-Santos, M., Turon-Sans, J., Muñoz, L., Ribosa-Nogué, Roser, Sala-Matavera, I., Sánchez-Saudinós, María Belén, Subirana, A., Videla Toro, Laura, Benejam, Bessy, Sirisi Dolcet, Sonia, Lehmann, S., Belbin, Olivia, Clarimón, Jordi, Blesa, Rafael, Pagonabarraga Mora, Javier, Rojas-Garcia, Ricard, Fortea, Juan, Lleó, Alberto, Universitat Autònoma de Barcelona, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona (UAB), Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III [Madrid] (ISC), German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Ludwig-Maximilians-Universität München (LMU), CIBER de Enfermedades Raras (CIBERER), and Salvy-Córdoba, Nathalie

Subjects
0301 basic medicine, Male, Pathology, Neurology, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, MESH: Neurodegenerative Diseases, Cohort Studies, 0302 clinical medicine, Cerebrospinal fluid, Neurofilament Proteins, MESH: Early Diagnosis, Medicine, Amyotrophic lateral sclerosis, MESH: Neurofilament Proteins, MESH: Cohort Studies, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], MESH: Aged, Multidisciplinary, Neurodegeneration, Neurodegenerative Diseases, MESH: Follow-Up Studies, Disease Progression, Female, MESH: Disease Progression, Alzheimer's disease, Frontotemporal dementia, medicine.medical_specialty, Science, Neuroaxonal Dystrophies, Article, Progressive supranuclear palsy, 03 medical and health sciences, mental disorders, Humans, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Aged, MESH: Humans, business.industry, Dementia with Lewy bodies, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, medicine.disease, MESH: Neuroaxonal Dystrophies, MESH: Male, 030104 developmental biology, Early Diagnosis, MESH: Biomarkers, business, MESH: Female, 030217 neurology & neurosurgery, Biomarkers, Follow-Up Studies
Abstract

Altres ajuts: "Marató TV3" grant (20141210, 044412, 20143710). Cerebrospinal fluid (CSF) biomarkers are useful in the diagnosis and the prediction of progression of several neurodegenerative diseases. Among them, CSF neurofilament light (NfL) protein has particular interest, as its levels reflect neuroaxonal degeneration, a common feature in various neurodegenerative diseases. In the present study, we analyzed NfL levels in the CSF of 535 participants of the SPIN (Sant Pau Initiative on Neurodegeneration) cohort including cognitively normal participants, patients with Alzheimer disease (AD), Down syndrome (DS), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). We evaluated the differences in CSF NfL accross groups and its association with other CSF biomarkers and with cognitive scales. All neurogenerative diseases showed increased levels of CSF NfL, with the highest levels in patients with ALS, FTD, CBS and PSP. Furthermore, we found an association of CSF NfL levels with cognitive impairment in patients within the AD and FTD spectrum and with AD pathology in DLB and DS patients. These results have implications for the use of NfL as a marker in neurodegenerative diseases.

Published
2020

205. Both Subjective Emotional Distress and Visual Handicap Correlate with Belin ABCD Classification in the Worse Eye as Measured with the “Keratoconus End-Points Assessment Questionnaire” (KEPAQ)

Author

Balparda K, Herrera-Chalarca T, Silva-Quintero LA, Torres-Soto SA, Segura-Muñoz L, and Vanegas-Ramirez CM

Subjects
Ophthalmology, genetic structures, sense organs, RE1-994, eye diseases, keratoconus – quality of life – vision ocular
Abstract

Kepa Balparda,1,2 Tatiana Herrera-Chalarca,3 Laura Andrea Silva-Quintero,4 Sneider Alexander Torres-Soto,4 Laura Segura-Muñoz,5 Claudia Marcela Vanegas-Ramirez6 1Department of Cornea and Refractive Surgery, Black Mammoth Surgical, Medellín, Colombia; 2Predoctoral Research Group, Universidad de Valladolid, Valladolid, Spain; 3Department of Clinical Research, Black Mammoth Surgical, Medellín, Colombia; 4Medicarte, Medellín, Colombia; 5School of Medicine, Universidad Pontificia Bolivariana, Medellín, Colombia; 6Department of Ophthalmology, Universidad Pontificia Bolivariana, Medellín, ColombiaCorrespondence: Kepa Balparda Email kb@kepabalparda.comBackground: Keratoconus is a disease characterized by progressive corneal distortion and quality of vision. So far, no study using disease-specific scales has evaluated whether different stages of the disease correlate with higher quality of life (QoL) compromise.Methods: A total of 114 patients with a confirmed diagnosis of Keratoconus were included in this retrospective study. All patients underwent a clinical and a Pentacam evaluation. They were also administered the “Keratoconus End-Points Assessment Questionnaire” (KEPAQ). Belin ABCD criteria were used for Keratoconus classification. “Better eye” was defined as the eye with the lowest maximum keratometry value. Spearman Rank Order Correlation was used to determine the correlation between the different Belin criteria and the KEPAQ scores in both subscales.Results: Mean age was 28.13 ± 11.57 years, with 39.47% of patients being male. Mean score for the KEPAQ-E was 2.33 ± 3.40 Logit, while for the KEPAQ-F, it was 1.85 ± 3.61 Logit. Criteria A (anterior elevation), B (posterior elevation) and D (visual acuity) in the worse eye correlated significantly with a greater decrease in QoL (p < 0.05 for all correlations). No correlation could be found regarding the better eye.Conclusion: A greater corneal distortion in the worse eye, as determined by Belin ABCD, is associated with a greater decrease in patient’s QoL. Surgical improvement of the worse eye should probably be performed before surgery of the better eye, as it may provide a better response regarding the quality of life improvement.Keywords: Keratoconus, quality of life, vision ocular

Published
2020

206. El Aprendizaje-Servicio Universitario como promotor del compromiso social en el alumnado de Ciencias de la Actividad Física y el Deporte

Author

García-Rico, Luis, Martínez Muñoz, L. Fernando, and Santos-Pastor, Mª. Luisa

Abstract

To face the profound economic, social, political and cultural changes that are taking place worldwide, social responsibility is required. Acting responsibly from social commitment means acting autonomously, making decisions and being protagonists of the actions we undertake to achieve prosperous changes for society. The main objective of this research study is to know and analyze the impact of the University Service-Learning on the social responsibility of Physical Activity and Sports students. The research study has been developed following an interpretive-critical perspective with an intrinsic case study research design. The participants and main protagonists of this research are 145 students of the Degree in Physical Activity and Sports Sciences and the Degree in Primary Education Teacher with a mention in Physical Education from the Autonomous University of Madrid. Different techniques and instruments were used to collect the information: group interviews, focus groups, reflective questionnaires and the student portfolio. It is concluded that the experiences of University Service-Learning in Physical Activity and Sports seem to have a vital and coherent meaning with initial training and social progress, being considerably appropriate to train responsible citizens capable of generating social changes and favoring the inclusion of vulnerable social groups., Para afrontar los profundos cambios económicos, sociales, políticos y culturales que se están produciendo a nivel mundial requiere tomar conciencia y ser crítico ante los efectos sobre la sociedad. Es decir, actuar con responsabilidad desde el compromiso social, hacerlo con autonomía, tomando decisiones y siendo protagonistas de las acciones que se emprenden para lograr cambios prósperos para la sociedad. El presente estudio de investigación tiene como principal objetivo conocer y analizar la incidencia del Aprendizaje-Servicio Universitario sobre el compromiso social del alumnado universitario. El estudio de investigación se ha desarrollado siguiendo una perspectiva interpretativa-crítica mediante un estudio de casos intrínseco. Los participantes y principales protagonistas de esta investigación son 145 estudiantes del Grado en Ciencias de la Actividad Física y el Deporte y del Grado en Maestro/a en Educación Primaria con mención en Educación Física de la Universidad Autónoma de Madrid. Se emplearon distintas técnicas e instrumentos para la recogida de la información: entrevistas grupales en profundidad, grupos focales, cuestionarios reflexivos y portafolio del alumnado. Se concluye que las experiencias de Aprendizaje-Servicio Universitario en Actividad Física y Deporte tienen impacto sobre el compromiso social del alumnado durante su formación inicial, formar ciudadanos responsables, capaces de generar cambios sociales y favorecer la inclusión de colectivos sociales vulnerados.

Published
2022

207. Marketing motivations influencing food choice in 16 countries: segmentation and cluster analysis

Author

Henriques, C., Matos, A., Malva, M., Bartkiene, E., Djekić, I., Tarcea, M., Matek Sarić, M., Černelič-Bizjak, M., Dolar, V., EL- Kenawy, A., Ferreira, V., Klava, D., Korzeniowska, M., Vittadini, E., Leal, M., Frez-Muñoz, L., Papageorgiou, M., Szűcs, V., Correia, P.M.R. and Guiné, R.P.F.

Subjects
marketing segmentation, food consumption, eating motivation, cluster analysis
Abstract

Food behaviour is governed by different kinds of motivations, some of individual nature and others related with the external food environment. This study investigated the eating motivations in sixteen countries with respect to commercial and marketing influences on food choices. The questionnaire survey was developed between September 2017 and June 2018, via online tools, targeting a convenience sample of residents in sixteen countries (Argentina, Brazil, Croatia, Egypt, Greece, Hungary, Italy, Latvia, Lithuania, Netherlands, Poland, Portugal, Romania, Serbia, Slovenia and the United States of America). The number of valid responses received was 11, 919 participants. The data were treated using SPSS software, and the main statistical techniques used included exploratory factor analysis, evaluation of internal reliability through Cronbach’s alpha, cluster analysis (hierarchical and k-means) and logistic regression. The results obtained showed two groups of people: low motivated and notably motivated consumers. The results showed high asymmetries between countries, with highest percentage of highly motivated consumers in Egypt and the lowest percentage of highly motivated in Portugal. It was further observed that consumers more influenced by commercial and marketing aspects (the notably motivated) tend to be women, young, single, less educated, less likely to be professionally active, and those who live mostly in rural or suburban areas. Less exercise and overweight are also factors associated with greater propensity for commercial and marketing motivations. Furthermore, health problems such as shellfish or gluten intolerance, hypertension and high cholesterol confer less propensity to be in the segment of the notably motivated consumers. In conclusion, this work highlighted the role of geographic, sociodemographic and lifestyle factors as food choice determinants.

Published
2022

208. Marketing motivations influencing food choice in 16 countries: segmentation and cluster analysis

Author

Henriques, Carla, Matos, Ana, Malva, Madalena, Bartkiene, E., Djekic, I., Tarcea, M., Saric, M., Bizjak, M., Dolar, V., EL-Kenawy, A., Ferreira, V., Klava, D., Korzeniowska, M., Vittadini, E., Leal, M., Frez-Muñoz, L., Papageorgiou, M., and Guiné, Raquel

Subjects
food consumption, eating motivation, marketing segmentation, cluster analysis
Abstract

Food behaviour is governed by different kinds of motivations, some of individual nature and others related with the external food environment. This study investigated the eating motivations in sixteen countries with respect to commercial and marketing influences on food choices. The questionnaire survey was developed between September 2017 and June 2018, via online tools, targeting a convenience sample of residents in sixteen countries (Argentina, Brazil, Croatia, Egypt, Greece, Hungary, Italy, Latvia, Lithuania, Netherlands, Poland, Portugal, Romania, Serbia, Slovenia and the United States of America). The number of valid responses received was 11,919 participants. The data were treated using SPSS software, and the main statistical techniques used included exploratory factor analysis, evaluation of internal reliability through Cronbach’s alpha, cluster analysis (hierarchical and k-means) and logistic regression. The results obtained showed two groups of people: low motivated and notably motivated consumers. The results showed high asymmetries between countries, with highest percentage of highly motivated consumers in Egypt and the lowest percentage of highly motivated in Portugal. It was further observed that consumers more influenced by commercial and marketing aspects (the notably motivated) tend to be women, young, single, less educated, less likely to be professionally active, and those who live mostly in rural or suburban areas. Less exercise and overweight are also factors associated with greater propensity for commercial and marketing motivations. Furthermore, health problems such as shellfish or gluten intolerance, hypertension and high cholesterol confer less propensity to be in the segment of the notably motivated consumers. In conclusion, this work highlighted the role of geographic, sociodemographic and lifestyle factors as food choice determinants. info:eu-repo/semantics/publishedVersion

Published
2022

209. Differential attenuation in star-forming galaxies at 0.3 $\lesssim$ $z$ $\lesssim$ 1.5 in the SHARDS/CANDELS field

Author

Rodríguez-Muñoz, L., Rodighiero, G., Pérez-González, P. G., Talia, M., Baronchelli, I., Morselli, L., Renzini, A., Puglisi, A., Grazian, A., Zanella, A., Mancini, C., Feltre, A., Romano, M., García, A. Vidal, Franceschini, A., Pampliega, B. Alcalde, Cassata, P., Costantin, L., Sánchez, H. Domínguez, Espino-Briones, N., Iani, E., Koekemoer, A., Lumbreras-Calle, A., Rodríguez-Espinosa, J. M., Laboratoire de physique de l'ENS - ENS Paris (LPENS), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Sorbonne Université (SU)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Laboratoire de physique de l'ENS - ENS Paris (LPENS (UMR_8023)), École normale supérieure - Paris (ENS Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)

Subjects
Astrophysics of Galaxies (astro-ph.GA), FOS: Physical sciences, Astrophysics::Solar and Stellar Astrophysics, High Energy Physics::Experiment, Astrophysics::Earth and Planetary Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Astrophysics of Galaxies, Astrophysics::Galaxy Astrophysics
Abstract

We use a sample of 706 galaxies, selected as [OII]$\lambda$3727 ([OII]) emitters in the Survey for High-$z$ Absorption Red and Dead Sources (SHARDS) on the CANDELS/GOODS-N field, to study the differential attenuation of the nebular emission with respect to the stellar continuum. The sample includes only galaxies with a counterpart in the infrared and $\mathrm{log}_{10}(M_{*}/\mathrm{M}_{\odot})$ $>$ 9, over the redshift interval 0.3 $\lesssim$ $z$ $\lesssim$ 1.5. Our methodology consists in the comparison of the star formation rates inferred from [OII] and H$\alpha$ emission lines with a robust quantification of the total star-forming activity (${SFR}_{\mathrm{TOT}}$) that is independently estimated based on both infrared and ultraviolet (UV) luminosities. We obtain $f$$=$$E(B-V)_{\mathrm{stellar}}$/$E(B-V)_{\mathrm{nebular}}$ $=$ 0.69$^{0.71}_{0.69}$ and 0.55$^{0.56}_{0.53}$ for [OII] and H$\alpha$, respectively. Our resulting $f$-factors display a significant positive correlation with the UV attenuation and shallower or not-significant trends with the stellar mass, the $SFR_{\mathrm{TOT}}$, the distance to the main sequence, and the redshift. Finally, our results favour an average nebular attenuation curve similar in shape to the typical dust curve of local starbursts., Comment: 23 pages, 10 figures, 3 tables; accepted for publication in MNRAS

Published
2022

210. Daily tenofovir disoproxil fumarate/emtricitabine and hydroxychloroquine for pre-exposure prophylaxis of COVID-19: a double-blind placebo controlled randomized trial in healthcare workers

Author

Polo R, García-Albéniz X, Terán C, Morales M, Rial-Crestelo D, Garcinuño MA, García Del Toro M, Hita C, Gómez-Sirvent JL, Buzón L, Díaz de Santiago A, Pérez Arellano JL, Sanz J, Bachiller P, Martínez Alfaro E, Díaz-Brito V, Masiá M, Hernández-Torres A, Guerra J, Santos J, Arazo P, Muñoz L, Arribas JR, Martínez de Salazar P, Moreno S, Hernán MA, Del Amo J, Rosa Polo, Berenguer J, Martínez E, Hernán M, and García de Albéniz X

Abstract

OBJECTIVE: To assess the effect of hydroxychloroquine (HCQ) and Tenofovir disoproxil fumarate/Emtricitabine (TDF/FTC) as pre-exposure prophylaxis on COVID-19 risk. METHODS: EPICOS is a double-blind, placebo-controlled randomized trial conducted in Spain, Bolivia, and Venezuela. Healthcare workers with negative SARS-CoV-2 IgM/IgG test were randomly assigned to: daily TDF/FTC plus HCQ for 12 weeks, TDF/FTC plus HCQ placebo, HCQ plus TDF/FTC placebo and TDF/FTC placebo plus HCQ placebo. Randomization was performed in groups of four. Primary outcome was laboratory-confirmed, symptomatic COVID-19. We also studied any (symptomatic or asymptomatic) COVID-19. We compared group-specific 14-week risks via differences and ratios with 95% confidence intervals (CI). RESULTS: Of 1002 individuals screened, 926 (92.4%) were eligible and there were 14 cases of symptomatic COVID-19: 220 were assigned to the TDF/FTC plus HCQ group (3 cases), 231 to the TDF/FTC placebo plus HCQ group (3 cases), 233 to the TDF/FTC plus HCQ placebo group (3 cases), and 223 to the double placebo group (5 cases). Compared with the double placebo group, 14-week risk ratios (95% CI) of symptomatic COVID-19 were 0.39 (0.00, 1.98) for TDF+HCQ, 0.34 (0.00, 2.06) for TDF, and 0.49 (0.00, 2.29) for HCQ. Corresponding risk ratios of any COVID-19 were 0.51 (0.21, 1.00) for TDF+HCQ, 0.81 (0.44, 1.49) for TDF, and 0.73 (0.41, 1.38) for HCQ. Adverse events were generally mild. CONCLUSION: The target sample size was not met. Our findings are compatible with both benefit and harm of pre-exposure prophylaxis with TDF/FTC and HCQ, alone or in combination, compared with placebo.

Published
2022

212. Evolución hacia la cerámica fotovoltaica

Author

Sánchez-Muñoz, L.

Subjects
traditional ceramics, advanced ceramics, photovoltaic ceramics, energy efficiency, cerámica tradicional, cerámica avanzada, energía fotovoltaica, eficiencia energética, Clay industries. Ceramics. Glass, TP785-869
Abstract

Nowadays there are two types of ceramic materials, i.e. traditional and advanced. The origin and development of the first one occurred before the revolutionary changes in Science and Technology of the nineteenth century, while the second one is its direct consequence. The traditional ceramics, which are related primarily to elementary human needs, in particular its constructions, is very homogeneous with respect to their formulations, being their diversity mainly linked to the decorative aspects of one surface. Advanced ceramics are characterized by a wide variety of materials with specific physical and chemical responses to radiation and electromagnetic fields, where major economic benefits are mainly related to secondary human needs such as telecommunications. As a result of the current global crisis, traditional buildings could be rehabilitated and/or replaced by energy efficient buildings, also called zero-energy buildings. In them there is a balance between energy consumed and produced “in situ”, and also using environmentally friendly materials. The direct consequence of this trend will be the evolution of ceramics by partial hybridization of its two ancestors, with special importance of semiconductor compounds, to the production of electrical energy as the basic objective, in this work called photovoltaic ceramics.Actualmente se distinguen dos tipos de cerámica, una tradicional y otra avanzada. El origen y desarrollo de la primera es anterior a los cambios revolucionarios en Ciencia y Tecnológica del siglo XIX, mientras que la segunda es su consecuencia directa. La cerámica tradicional, que está relacionada sobre todo con las necesidades humanas primarias y en particular a sus construcciones, es muy homogénea respecto a sus formulaciones, estando su diversidad ligada principalmente a los aspectos decorativos de una de sus superficies. La cerámica avanzada se caracteriza por una gran diversidad de materiales con respuestas físico-químicas específicas frente a las radiaciones y a los campos electromagnéticos, y sus principales beneficios económicos están ligados sobre todo con las necesidades humanas secundarias tales como las telecomunicaciones. Como consecuencia de la actual crisis de carácter global, las construcciones tradicionales pudieran ser rehabilitadas y/o sustituidas por edificios con eficiencia energética, también denominados edificios de energía cero. En ellos existe equilibrio entre la energía consumida y la producida “in situ”, y utilizan materiales respetuosos con el Medioambiente. La consecuencia directa de esta tendencia será la evolución de la cerámica por hibridación parcial de sus dos ancestros, con especial protagonismo de los semiconductores, hacia la producción de energía eléctrica, materiales a los que en este trabajo denominamos cerámica fotovoltaica.

Published
2011
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217. Differential attenuation in star-forming galaxies at 0.3 ≲ z ≲ 1.5 in the SHARDS/CANDELS field

Author

Rodríguez-Muñoz, L, primary, Rodighiero, G, additional, Pérez-González, P G, additional, Talia, M, additional, Baronchelli, I, additional, Morselli, L, additional, Renzini, A, additional, Puglisi, A, additional, Grazian, A, additional, Zanella, A, additional, Mancini, C, additional, Feltre, A, additional, Romano, M, additional, Vidal García, A, additional, Franceschini, A, additional, Alcalde Pampliega, B, additional, Cassata, P, additional, Costantin, L, additional, Domínguez Sánchez, H, additional, Espino-Briones, N, additional, Iani, E, additional, Koekemoer, A, additional, Lumbreras-Calle, A, additional, and Rodríguez-Espinosa, J M, additional

Published
2021
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218. Identification of Single Spectral Lines in Large Spectroscopic Surveys Using UMLAUT: an Unsupervised Machine-learning Algorithm Based on Unbiased Topology

Author

Baronchelli, I., primary, Scarlata, C. M., additional, Rodríguez-Muñoz, L., additional, Bonato, M., additional, Morselli, L., additional, Vaccari, M., additional, Carraro, R., additional, Barrufet, L., additional, Henry, A., additional, Mehta, V., additional, Rodighiero, G., additional, Baruffolo, A., additional, Bagley, M., additional, Battisti, A., additional, Colbert, J., additional, Dai, Y. S., additional, De Pascale, M., additional, Dickinson, H., additional, Malkan, M., additional, Mancini, C., additional, Rafelski, M., additional, and Teplitz, H. I., additional

Published
2021
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219. Massive Star Cluster Formation and Destruction in Luminous Infrared Galaxies in GOALS. II. An ACS/WFC3 Survey of Nearby LIRGs

Author

Linden, S. T., primary, Evans, A. S., additional, Larson, K., additional, Privon, G. C., additional, Armus, L., additional, Rich, J., additional, Díaz-Santos, T., additional, Murphy, E. J., additional, Song, Y., additional, Barcos-Muñoz, L., additional, Howell, J., additional, Charmandaris, V., additional, Inami, H., additional, U, V., additional, Surace, J. A., additional, Mazzarella, J. M., additional, and Calzetti, D., additional

Published
2021
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220. Adherence to Direct Oral Anticoagulants in Patients With Non-Valvular Atrial Fibrillation: A Cross-National Comparison in Six European Countries (2008–2015)

Author

Sabaté, M., primary, Vidal, X., additional, Ballarin, E., additional, Rottenkolber, M., additional, Schmiedl, S., additional, Grave, B., additional, Huerta, C., additional, Martin-Merino, E., additional, Montero, D., additional, Leon-Muñoz, L. M., additional, Gasse, C., additional, Moore, N., additional, Droz, C., additional, Lassalle, R., additional, Aakjær, M., additional, Andersen, M., additional, De Bruin, M. L., additional, Souverein, P., additional, Klungel, O. H., additional, Gardarsdottir, H., additional, and Ibáñez, L., additional

Published
2021
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229. CTA – the World’s largest ground-based gamma-ray observatory

Author

Zanin, Roberta, primary, Abdalla, H., additional, Abe, H., additional, Abe, S., additional, Abusleme, A., additional, Acero, F., additional, Acharyya, A., additional, Acin Portella, V., additional, Ackley, K., additional, Adam, R., additional, Adams, C., additional, Adhikari, S.S., additional, Aguado Ruesga, I., additional, Agudo, I., additional, Aguilera, R., additional, Aguirre Santaella, A., additional, Aharonian, F., additional, Alberdi, A., additional, Alfaro, R., additional, Alfaro, J., additional, Alispach, C., additional, Aloisio, R., additional, Alves Batista, R., additional, Amans, J.P., additional, Amati, L., additional, Amato, E., additional, Ambrogi, L., additional, Ambrosi, G., additional, Ambrosio, M., additional, Ammendola, R., additional, Anderson, J., additional, Anduze, M., additional, Anguner, E.O., additional, Antonelli, L.A., additional, Antonuccio, V., additional, Antoranz, P., additional, Anutarawiramkul, R., additional, Aragunde Gutierrez, J., additional, Aramo, C., additional, Araudo, A., additional, Araya, M., additional, Arbet Engels, A., additional, Arcaro, C., additional, Arendt, V., additional, Armand, C., additional, Armstrong, T., additional, Arqueros, F., additional, Arrabito, L., additional, Arsioli, B., additional, Artero, M., additional, Asano, K., additional, Ascasibar, Y., additional, Aschersleben, J., additional, Ashley, M., additional, Attina, P., additional, Aubert, P., additional, B. Singh, C., additional, Baack, D., additional, Babic, A., additional, Backes, M., additional, Baena, V., additional, Bajtlik, S., additional, Baktash, A., additional, Balazs, C., additional, Balbo, M., additional, Ballester, O., additional, Ballet, J., additional, Balmaverde, B., additional, Bamba, A., additional, Bandiera, R., additional, Baquero Larriva, A., additional, Barai, P., additional, Barbier, C., additional, Barbosa Martins, V., additional, Barcelo, M., additional, Barkov, M., additional, Barnard, M., additional, Baroncelli, L., additional, Barres de Almeida, U., additional, Barrio, J.A., additional, Bastieri, D., additional, Batista, P.I., additional, Batkovic, I., additional, Bauer, C., additional, Bautista González, R., additional, Baxter, J., additional, Becciani, U., additional, Becerra González, J., additional, Becherini, Y., additional, Beck, G., additional, Becker Tjus, J., additional, Bednarek, W., additional, Belfiore, A., additional, Bellizzi, L., additional, Belmont, R., additional, Benbow, W., additional, Berge, D., additional, Bernardini, E., additional, Bernardos, M.I., additional, Bernlöhr, K., additional, Berti, A., additional, Berton, M., additional, Bertucci, B., additional, Beshley, V., additional, Bhatt, N., additional, Bhattacharyya, S., additional, Bhattacharyya, W., additional, Bi, B. Y., additional, Bicknell, G., additional, Biederbeck, N., additional, Bigongiari, C., additional, Biland, A., additional, Bird, R., additional, Bissaldi, E., additional, Biteau, J., additional, Bitossi, M., additional, Blanch, O., additional, Blank, M., additional, Blazek, J., additional, Bobin, J., additional, Boccato, C., additional, Bocchino, F., additional, Boehm, C., additional, Bohacova, M., additional, Boisson, C., additional, Boix, J., additional, Bolle, J.P., additional, Bolmont, J., additional, Bonanno, G., additional, Bonavolontà, C., additional, Bonneau Arbeletche, L., additional, Bonnoli, G., additional, Bordas, P., additional, Borkowski, J., additional, Bose, R., additional, Bose, D., additional, Bosnjak, Z., additional, Bottacini, E., additional, Böttcher, Markus, additional, Botticella, M.T., additional, Boutonnet, C., additional, Bouyjou, F., additional, Bozhilov, V., additional, Bozzo, E., additional, Brahimi, L., additional, Braiding, C., additional, Brau Nogue, S., additional, Breen, S., additional, Bregeon, J., additional, Breuhaus, M., additional, Brill, A., additional, Brisken, W., additional, Brocato, E., additional, Brown, A.M., additional, Brügge, K., additional, Brun, P., additional, Brun, F., additional, Brunetti, L., additional, Brunetti, G., additional, Bruno, P., additional, Bruno, A., additional, Bruzzese, A., additional, Bucciantini, N., additional, Buckley, J. H., additional, Bühler, R., additional, Bulgarelli, A., additional, Bulik, T., additional, Bünning, M., additional, Bunse, M., additional, Burton, M., additional, Burtovoi, A., additional, Buscemi, M., additional, Buschjager, S., additional, Busetto, G., additional, Buss, J., additional, Byrum, K., additional, Caccianiga, A., additional, Cadoux, F., additional, Calanducci, A., additional, Calderon, C., additional, Calvo Tovar, J., additional, Cameron, R. A., additional, Campana, P., additional, Canestrari, R., additional, Cangemi, F., additional, Cantlay, B., additional, Capalbi, M., additional, Capasso, M., additional, Cappi, M., additional, Caproni, A., additional, Capuzzo Dolcetta, R., additional, Caraveo, P., additional, Cárdenas, V., additional, Cardiel, L., additional, Cardillo, M., additional, Carlile, C., additional, Caroff, S., additional, Carosi, R., additional, Carosi, A., additional, Carquin, E., additional, Carrere, M., additional, Casandjian, J.M., additional, Casanova, S., additional, Cassol, F., additional, Catalani, F., additional, Catalano, O., additional, Cauz, D., additional, Ceccanti, A., additional, Celestino Silva, C., additional, Cerny, K., additional, Cerruti, M., additional, Chabanne, E., additional, Chadwick, P., additional, Chai, Y., additional, Chambery, P., additional, Champion, C., additional, Chaty, S., additional, Chen, A., additional, Cheng, K., additional, Chernyakova, M., additional, Chiaro, G., additional, Chiavassa, A., additional, Chikawa, M., additional, Chitnis, V.R., additional, Chudoba, J., additional, Chytka, L., additional, Cikota, S., additional, Circiello, A., additional, Clark, P., additional, Colak, M., additional, Colombo, E., additional, Colonges, S., additional, Comastri, A., additional, Compagnino, A., additional, Conforti, V., additional, Congiu, E., additional, Coniglione, R., additional, Conrad, J., additional, Conte, F., additional, Contreras, J.L., additional, Coppi, P., additional, Cornat, R., additional, Coronado Blazquez, J., additional, Cortina, J., additional, Costa, A., additional, Costantini, H., additional, Cotter, G., additional, Courty, B., additional, Covino, S., additional, Crestan, S., additional, Cristofari, P., additional, Crocker, R., additional, Croston, J., additional, Cubuk, K., additional, Cuevas, O., additional, Cui, X., additional, Cusumano, G., additional, Cutini, S., additional, D'Amico, G., additional, D'Ammando, F., additional, D'Avanzo, P., additional, Da Vela, P., additional, Dadina, M., additional, Dai, S., additional, Dalchenko, M., additional, Dall'Ora, M., additional, Daniel, M.K., additional, Dauguet, J., additional, Davids, I., additional, Davies, J., additional, Dawson, B., additional, De Angelis, A., additional, de Araujo Carvalho, A.E., additional, de Bony de Lavergne, M., additional, De Cesare, G., additional, de Frondat, F., additional, de la Calle, I., additional, de Gouveia Dal Pino, E., additional, De Lotto, B., additional, De Luca, A., additional, De Martino, D., additional, de Naurois, M., additional, de Ona Wilhelmi, E., additional, De Palma Persio, F., additional, De Simone, N., additional, de Souza Valle, V., additional, Delagnes, E., additional, Deleglise Reznicek, G., additional, Delgado, C., additional, Delgado Giler, A.G., additional, Delgado Mengual Valle, J., additional, della Volpe, D., additional, Depaoli, D., additional, Devin, J., additional, Di Girolamo, T., additional, Di Giulio Pierro, C., additional, Di Venere, L., additional, Díaz, C., additional, Dib, C., additional, Diebold, S., additional, Digel, S., additional, Djannati Atai, A., additional, Djuvsland, J., additional, Dmytriiev, A., additional, Docher, K., additional, Domínguez, A., additional, Dominis Prester, D., additional, Donini, A., additional, Dorner, D., additional, Doro, M., additional, dos Anjos, Rita Cassia, additional, Dournaux, J.L., additional, Downes, T., additional, Drake, G., additional, Drass, H., additional, Dravins, D., additional, Duangchan, C., additional, Duara, A., additional, Dubus, G., additional, Ducci, L., additional, Duffy, C., additional, Dumora, D., additional, Dundas Mora, K., additional, Durkalec, A., additional, Dwarkadas, V.V., additional, Ebr, J., additional, Eckner, C., additional, Eder, J., additional, Edy, E., additional, Egberts, K., additional, Einecke, S., additional, Eleftheriadis, C., additional, Elsässer, D., additional, Emery, G., additional, Emmanoulopoulos, D., additional, Ernenwein, J.P., additional, Errando, M., additional, Escarate, P., additional, Escudero, J., additional, Espinoza, C., additional, Ettori, S., additional, Eungwanichayapant, A., additional, Evans, P., additional, Evoli, C., additional, Fairbairn, M., additional, Falceta Goncalves, D., additional, Falcone, A., additional, Fallah Ramazanı, V., additional, Falomo, R., additional, Farakos, K., additional, Fasola, G., additional, Fattorini, A., additional, Favre, Y., additional, Fedora, R., additional, Fedorova, E., additional, Feijen, K., additional, Feng, Q., additional, Ferrand, G., additional, Ferrara, G., additional, Ferreira, O., additional, Fesquet, M., additional, Fiandrini, E., additional, Fiasson, A., additional, Filipovic, M., additional, Fink, D., additional, Finley, J.P., additional, Fioretti, V., additional, Fiorillo, D.F.G., additional, Fiorini, M., additional, Flis, S., additional, Flores, H., additional, Foffano, L., additional, Fohr, C., additional, Fonseca, M.V., additional, Font, L., additional, Fontaine, G., additional, Fornieri, O., additional, Fortin, P., additional, Fortson, L., additional, Fouque, N., additional, Fraga, B., additional, Franceschini, A., additional, Franco, F.J., additional, Freixas Coromina, L., additional, Fresnillo, L., additional, Fugazza, D., additional, Fujita, Y., additional, Fukami, S., additional, Fukazawa, Y., additional, Fulla, D., additional, Funk, S., additional, Furniss, A., additional, Gabici, S., additional, Gaggero, D., additional, Galanti, G., additional, Galdemard, P., additional, Gallant, Y. A., additional, Galloway, D., additional, Gallozzi, S., additional, Gammaldi, V., additional, Garcia, R., additional, García-Muñoz, L. E., additional, Garcia Lopez, E., additional, Gargano, F., additional, Gargano, C., additional, Garozzo, S., additional, Gascon, D., additional, Gasparetto, T., additional, Gasparrini, D., additional, Gasparyan, H., additional, Gaug, M., additional, Geffroy, N., additional, Gent, A., additional, Germani, S., additional, Ghalumyan, A., additional, Ghedina, A., additional, Ghirlanda, G., additional, Gianotti, F., additional, Giarrusso, S., additional, Giarrusso, M., additional, Giavitto, G., additional, Giebels, B., additional, Giglietto, N., additional, Gika, V., additional, Gillardo, F., additional, Gimenes, R., additional, Giordano, F., additional, Giro, E., additional, Giroletti, M., additional, Giuliani, Andrea, additional, Gjaja, M., additional, Glicenstein, J.F., additional, Gliwny, P., additional, Goksu, H., additional, Goldoni, P., additional, Gomez, J.L., additional, Gonzalez, M.M., additional, Gonzalez, J.M., additional, Gothe, K.S., additional, Gotz Coelho, D., additional, Grabarczyk, T., additional, Graciani, R., additional, Grandi, P., additional, Grasseau, G., additional, Grasso, D., additional, Green, D., additional, Green, J., additional, Greenshaw, T., additional, Grespan, P., additional, Grillo, A., additional, Grondin, M.H., additional, Grube, J., additional, Guarino, V., additional, Guest, B., additional, Gueta, O., additional, Günduz, M., additional, Gunji, S., additional, Gyuk, G., additional, Hackfeld, J., additional, Hadasch, D., additional, Hagge, L., additional, Hahn, A., additional, Hajlaoui, J.E., additional, Halim, A., additional, Hamal, P., additional, Hanlon, W., additional, Harada, Y., additional, Hardcastle, M.J., additional, Harvey Collado, M., additional, Haubold, T., additional, Haupt, A., additional, Havelka, M., additional, Hayashi, K., additional, Hayashida, M., additional, He, H., additional, Heckmann, L., additional, Heller, M., additional, Henault, F., additional, Henri, Gilles, additional, Hermann, G., additional, Hernández Cadena, S., additional, Herrera Llorente, J., additional, Hervet, O., additional, Hinton, J., additional, Hiramatsu, A., additional, Hirotani, K., additional, Hnatyk, B., additional, Hnatyk, R., additional, Hoang, J.K., additional, Hoffmann, D. H.H., additional, Hoischen, C., additional, Holder, J., additional, Holler, M., additional, Hona, B., additional, Horan, D., additional, Horns, Dieter, additional, Horvath, P., additional, Houles, J., additional, Hrabovsky, M., additional, Hrupec, D., additional, Huang, Y., additional, Huet, J.‑M., additional, Hughes, G., additional, Hull, G., additional, Humensky, T.B., additional, Hütten, M., additional, Iarlori, M., additional, Illa, J.M., additional, Imazawa, R., additional, Inada, T., additional, Incardona, F., additional, Ingallinera, A., additional, Inoue, S., additional, Inoue, T., additional, Inoue, Y., additional, Iocco, F., additional, Ioka, K., additional, Ionica, M., additional, Iovenitti, S., additional, Iriarte, A., additional, Ishio, K., additional, Ishizaki, W., additional, Iwamura, Y., additional, Jacquemier, J., additional, Jacquemont, M., additional, Jamrozy, M., additional, Janecek, P., additional, Jankowsky, F., additional, JardinBlicq, A., additional, Jarnot, C., additional, Jean Martínez, P., additional, Jocou, L., additional, Jordana, N., additional, Josselin, M., additional, JungRichardt, I., additional, Junqueira, F.J.P.A., additional, Juramy Gilles, C., additional, Kaaret, P., additional, Kadowaki, L.H.S., additional, Kagaya, M., additional, Kankanyan, R., additional, Kantzas, D., additional, Karas, V., additional, Karastergiou, A., additional, Karkar, S., additional, Kasperek, J., additional, Katagiri, H., additional, Kataoka, J., additional, Katarzynski, K., additional, Katsuda, S., additional, Kawanaka, N., additional, Kazanas, D., additional, Kerszberg, D., additional, Khélifi, B., additional, Kherlakian, M.C., additional, Kian, T.P., additional, Kieda, D.B., additional, Kihm, T., additional, Kim, S., additional, Kisaka, S., additional, Kissmann, R., additional, Kleijwegt, R., additional, Kluge, G., additional, Kluźniak, W., additional, Knapp, J., additional, Kobakhidze, A., additional, Kobayashi, Y., additional, Koch, B., additional, Kocot, J., additional, Kohri, K., additional, Komin, N., additional, Kong, A., additional, Kosack, K., additional, Krack, F., additional, Krause, M., additional, Krennrich, F., additional, Kubo, H., additional, Kudryavtsev, V. N., additional, Kunwar, S., additional, Kushida, J., additional, Kushwaha, P., additional, Parola, Barbera, additional, La Rosa, G., additional, Lahmann, R., additional, Lamastra, A., additional, Landoni, M., additional, Landriu, D., additional, Lang, R.G., additional, Lapington, J., additional, Laporte, P., additional, Lason, P., additional, Lasuik, J., additional, Lazendic Galloway, J., additional, Le Flour, T., additional, Le Sidaner, P., additional, Leach, S., additional, Lee, S.H., additional, Lee, W.H., additional, Lee Oliveira, S., additional, Lemiere, A., additional, Lemoine Goumard, M., additional, Lenain, J.P., additional, Leone, F., additional, Leray, V., additional, Leto, G., additional, Leuschner, F., additional, Lindemann, R., additional, Lindfors, E., additional, Linhoff, L., additional, Liodakis, I., additional, Lipniacka, A., additional, Lobo, M., additional, Lohse, Thomas, additional, Lombardi, S., additional, Lopez, A., additional, Lopez, M., additional, Lopez Coto, R., additional, Louis, F., additional, Louys, M., additional, Lucarelli, F., additional, Ludwig Boudi, H., additional, Luque Escamilla, P.L., additional, Maccarone, M.C., additional, Mach, E., additional, Maciejewski, A.J., additional, Mackey, J., additional, Maeght, P., additional, Maggio, C., additional, Maier, G., additional, Majumdar, P., additional, Makariev, M., additional, Mallamaci, M., additional, Malta Nunes de Almeida, R., additional, Malyshev, D., additional, Mandat, D., additional, Maneva, G., additional, Manganaro, M., additional, Manigot, P., additional, Mannheim, K., additional, Maragos, N., additional, Marano, D., additional, Marconi, M., additional, Marcowith, A., additional, Marculewicz, M., additional, Marcun, B., additional, Marin, J., additional, Marinello, N., additional, Marinos, P., additional, Markoff, S., additional, Marquez, P., additional, Marsella, G., additional, Martin, J. M., additional, Martin, P. G., additional, Martinez, M., additional, Martinez, G., additional, Martinez, O., additional, Martinez Huerta, H., additional, Marty, C., additional, Marx, R., additional, Masetti, N., additional, Massimino, P., additional, Matsumoto, H., additional, Matthews, N., additional, Maurin, G., additional, Max Moerbeck, W., additional, Maxted, N., additional, Mazziotta, M.N., additional, Mazzola, S.M., additional, Mbarubucyeye, J.D., additional, Mc Comb, L., additional, McHardy, I., additional, McKeague, S., additional, McMuldroch, S., additional, Medina, E., additional, Medina Miranda, D., additional, Melandri, A., additional, Melioli, C., additional, Melkumyan, D., additional, Menchiari, S., additional, Mereghetti, S., additional, Merino Arevalo, G., additional, Mestre, E., additional, Meunier, J.L., additional, Meures, T., additional, Micanovic, S., additional, Miceli, M., additional, Michailidis, M., additional, Michalowski, J., additional, Miener, T., additional, Mievre, I., additional, Miller, J. D., additional, Mineo, T., additional, Minev, M., additional, Miranda, J.M., additional, Mitchell, A., additional, Mizuno, T., additional, Mode, B. A., additional, Moderski, R., additional, Mohrmann, L., additional, Molinari, E., additional, Montaruli, T., additional, Monteiro, I., additional, Moore, C., additional, Moralejo, A., additional, Morcuende Parrilla, D., additional, Moretti, E., additional, Mori, K., additional, Moriarty, P., additional, Morik, K., additional, Morris, P., additional, Morselli, A., additional, Mosshammer, K., additional, Mukherjee, R., additional, Muller, J., additional, Mundell, C., additional, Mundet, J., additional, Murach, T., additional, Muraczewski, A., additional, Muraishi, H., additional, Musella, I., additional, Musumarra, A., additional, Nagai, A., additional, Nagataki, S., additional, Naito, T., additional, Nakamori, T., additional, Nakashima, K., additional, Nakayama, K., additional, Nakhjiri, N., additional, Naletto, G., additional, Naumann, D., additional, Nava, L., additional, Nawaz, M.A., additional, Ndiyavala, H., additional, Neise, D., additional, Nellen, L., additional, Nemmen, R., additional, Neyroud, N., additional, Ngernphat, K., additional, Nguyen Trung, T., additional, Nicastro, L., additional, Nickel, L., additional, Niemiec, J., additional, Nieto, D., additional, Nigro, C., additional, Nikołajuk, M., additional, Ninci, D., additional, Noda, K., additional, Nogami, Y., additional, Nolan, S., additional, Norris, R. P., additional, Nosek, D., additional, Nöthe, M., additional, Novotny, V., additional, Nozaki, S., additional, Nunio, F., additional, O'Brien, P., additional, Obara, K., additional, Ohira, Y., additional, Ohishi, M., additional, Ohm, S., additional, Oka, T., additional, Okazaki, N., additional, Okumura, A., additional, Oliver, C., additional, Olivera, G., additional, Olmi, B., additional, Orienti, M., additional, Orito, R., additional, Orlandini, M., additional, Orlando, E., additional, Osborne, J.P., additional, Ostrowski, M., additional, Otte, N., additional, Ovcharov, E., additional, Owen, E., additional, Oya, I., additional, Ozieblo, A., additional, Padovani, M., additional, Pagliaro, A., additional, Paizis, A., additional, Palatiello, M., additional, Palatka, M., additional, Palazzi, E., additional, Panazol, J.‑L., additional, Paneque, D., additional, Panny, S., additional, Pantaleo, F.R., additional, Panter, M., additional, Paolillo, M., additional, Papitto, A., additional, Paravac, A., additional, Paredes, J.M., additional, Pareschi, G., additional, Parmiggiani, N., additional, Parsons, R.D., additional, Paśko, P., additional, Patel, S. R., additional, Patricelli, B., additional, Pavletic, L., additional, Pavy, S., additional, Peer, A., additional, Pecimotika, M., additional, Pellegriti, M.G., additional, Peñil Del Campo, P., additional, Pepato, A., additional, Perard, S., additional, Perennes, C., additional, Peresano, M., additional, Perez Aguilera, A., additional, Perez Romero, J., additional, Perez Torres, M.A., additional, Persic, M., additional, Petrucci, P. O., additional, Petruk, O., additional, Peyaud, B., additional, Pfrang, K., additional, Pian, E., additional, Piatteli, P., additional, Pietropaolo, E., additional, Pillera, R., additional, Pimentel, D., additional, Pintore, F., additional, Pio Garcia, C., additional, Pirola, G., additional, Piron, F., additional, Pita, S., additional, Pohl, M., additional, Poireau, V., additional, Pollo, A., additional, Polo, M., additional, Pongkitivanichkul, C., additional, Porthault, J., additional, Powell, J., additional, Pozo, D., additional, Prado, R.R., additional, Prandini, E., additional, Prast, J., additional, Pressard, K., additional, Principe, G., additional, Produit, N., additional, Prokhorov, D., additional, Prokoph, H., additional, Przybilski, H., additional, Pueschel, E., additional, Pühlhofer, G., additional, Puljak, I., additional, Pumo, M.L., additional, Punch, M., additional, Queiroz, F., additional, Quinn, J., additional, Quirrenbach, A., additional, Rajda, P.J., additional, Rando, R., additional, Razzaque, S., additional, Recchia, S., additional, Reichherzer, P., additional, Reimer, O., additional, Reisenegger, A., additional, Remy, Q., additional, Renaud, M., additional, Reposeur, T., additional, Reville, B., additional, Reymond, J.M., additional, Reynolds, J., additional, Ribeiro, D., additional, Ribo, M., additional, Richards, G., additional, Rico, J., additional, Rieger, F., additional, Riitano, L., additional, Riquelme, M., additional, Riquelme, D., additional, Rivoire, S., additional, Rizi, V., additional, Roache, E., additional, Roche, M., additional, Rodriguez, J., additional, Rodriguez Fernandez, G., additional, Rodriguez Ramirez, J.C., additional, Rodriguez Vazquez, J.J., additional, Rojas, G., additional, Romano, P., additional, Romeo Lobato, G., additional, Romoli, C., additional, Roncadelli, M., additional, Rosado, J., additional, Rosales de Leon, A., additional, Rowell, G., additional, Rugliancich, A., additional, Ruiz del Mazo, J.E., additional, Rulten, C., additional, Russell, C., additional, Russo Hatlen, F., additional, Safi Harb, S., additional, Saha, L., additional, Sahakian, V., additional, Sailer, S., additional, Saito, T., additional, Sakaki, N., additional, Sakurai, S., additional, Salina, G., additional, Salzmann, H., additional, Sanchez, D., additional, Sandaker, H., additional, Sandoval, A., additional, Sangiorgi, P., additional, Sanguillon, M., additional, Sano, H., additional, Santander, M., additional, Santangelo, A., additional, Santos Lima, R., additional, Sanuy, A., additional, Sapozhnikov, L., additional, Saric, T., additional, Sarkar, S., additional, Sasaki, H., additional, Sasaki, N., additional, Sato, Y., additional, Saturni, F.G., additional, Sawada, M., additional, Schaefer, J., additional, Scherer, A., additional, Scherpenberg, J., additional, Schipani, P., additional, Schleicher, B., additional, Schmoll, J., additional, Schneider, M., additional, Schoorlemmer, H., additional, Schovanek, P., additional, Schussler, F., additional, Schwab, B., additional, Schwanke, U., additional, Schwarz, J., additional, Sciacca, E., additional, Scuderi, S., additional, Seglar Arroyo, M., additional, Seitenzahl, I., additional, Semikoz, D., additional, Sergijenko, O., additional, Serna Franco, J.E., additional, Seweryn, Karol, additional, Sguera, V., additional, Shalchi, A., additional, Shang, R.Y., additional, Sharma, P., additional, Sidoli, L., additional, Sieiro, J., additional, Siejkowski, H., additional, Sillanpaa, A., additional, Singh, B.B., additional, Singh, K.K., additional, Sinha, A., additional, Siqueira, C., additional, Sitarek, J., additional, Sizun, P., additional, Sliusar, V., additional, Sobczynska, D., additional, Sobrinho, R.W., additional, Sol, H., additional, Sottile, G., additional, Spackman, H., additional, Spencer, S., additional, Spengler, G., additional, Spiga, D., additional, Springer, W., additional, Stamerra, A., additional, Stanic, S., additional, Starling, R., additional, Stawarz, Ł., additional, Stefanik, Stanislav, additional, Stegmann, C., additional, Steiner, A., additional, Steinmassl, S., additional, Stella, C., additional, Sternberger, R., additional, Sterzel, M., additional, Stevens, C., additional, Stevenson, B., additional, Stolarczyk, T., additional, Stratta, G., additional, Straumann, U., additional, Striskovic, J., additional, Strzys, M., additional, Stuik, R., additional, Suchenek, M., additional, Sunada, Y., additional, Suomijarvi, T., additional, Suric, T., additional, Suzuki, H., additional, Swierk, P., additional, Szepieniec, T., additional, Tachihara, K., additional, Tagliaferri, G., additional, Tajima, H., additional, Tajima, N., additional, Tak, D., additional, Takahashi, H., additional, Takahashi, M., additional, Takata, J., additional, Takeishi, R., additional, Tam, T., additional, Tanaka, M., additional, Tanaka, T., additional, Tanaka, S., additional, Tavani, M., additional, Tavecchio, F., additional, Tavernier, T., additional, Taylor, A. Russ, additional, Tejedor, L.A., additional, Temnikov, P., additional, Terauchi, K., additional, Terrazas, J.C., additional, Terrier, R., additional, Terzic, T., additional, Teshima, M., additional, Thibaut, D., additional, Thocquenne, F., additional, Tian, W., additional, Tibaldo, L., additional, Tiengo, A., additional, Tluczykont, M., additional, Todero Peixoto, C.J., additional, Toma, K., additional, Tomankova, L., additional, Tomastik, J., additional, Tornikoski, M., additional, Torres, D.F., additional, Torresi, E., additional, Tosti, G., additional, Tosti, L., additional, Tothill, N., additional, Toussenel, F., additional, Tovmassian, G., additional, Trichard, C., additional, Trifoglio, M., additional, Trois, A., additional, Truzzi, S., additional, Tsiahina, A., additional, Turk, B., additional, Tutone, A., additional, Uchiyama, Y., additional, Utayarat, P., additional, Vaclavek, L., additional, Vacula, M., additional, Vagelli, V., additional, Vagnetti, F., additional, Valdivia, J.A., additional, Valentino, M., additional, Valio, A., additional, Vallage, B., additional, Vallania Quispe, P., additional, van den Berg, A.M., additional, van Driel, W., additional, van Eldik, C., additional, van Rensburg, C., additional, van Soelen, Brian, additional, Vandenbroucke, J., additional, Vasileiadis, G., additional, Vassiliev, V., additional, Vazquez Acosta, M., additional, Vecchi, M., additional, Vega, A., additional, Veh, J., additional, Veitch, P., additional, Venter, C., additional, Ventura, S., additional, Vercellone, S., additional, Verguilov, V., additional, Verna, G., additional, Vernetto, S., additional, Verzi, V., additional, Vettolani, G.P., additional, Veyssiere, C., additional, Viale, I., additional, Viana, A., additional, Viaux, N., additional, Vignatti, J., additional, Vigorito, C.F., additional, Villanueva, J., additional, Vitale, V., additional, Vittorini, V., additional, Vodeb, V., additional, Vogel, N., additional, Voisin, V., additional, Vorobiov, S., additional, Vrastil, M., additional, Vuillaume, T., additional, Wagner, S.J., additional, Wagner, P., additional, Wakazono, K., additional, Wakely, S.P., additional, Ward, M., additional, Warren, D., additional, Watson, J., additional, Wechakama, M., additional, Wegner, P., additional, Weinstein, A., additional, Weniger, C., additional, Werner, F., additional, Wetteskind, H., additional, White, M. L., additional, Wierzcholska, A., additional, Wiesand, S., additional, Wijers, R., additional, Wilkinson, M., additional, Will, M., additional, Williams, J., additional, Williamson, T. J., additional, Wolter, A., additional, Wong, Y.W., additional, Wood, M., additional, Yamamoto, T., additional, Yamamoto, H., additional, Yamane, Y., additional, Yamazaki, R., additional, Yanagita, S., additional, Yang, L., additional, Yoo, S., additional, Yoshida, T., additional, Yoshikoshi, T., additional, Yu, P., additional, Yusafzai, A., additional, Zacharias, Michael, additional, Zaldivar, B., additional, Zampieri, L., additional, Zanin, R., additional, Zanmar Sanchez, R., additional, Zaric, D., additional, Zavrtanik, M., additional, Zavrtanik, D., additional, Zdziarski, Andrzej, additional, Zech, A., additional, Zechlin, H., additional, Zenin, A., additional, Zerwekh, A., additional, Ziętara, K., additional, Zink, A., additional, Ziolkowski, J., additional, Zivec, M., additional, and Zmija, A., additional

Published
2021
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239. HCV eradication with IFN-based therapy does not completely restore gene expression in PBMCs from HIV/HCV-coinfected patients

Author

Brochado Kith, Óscar, Martínez, Isidoro, Berenguer, Juan, Medrano, Luz María, González-García, Juan, Jiménez-Sousa, María Ángeles, Carrero, Ana, Hontañón Antoñana, Víctor, Navarro, Jordi, Guardiola Tey, Jose Maria, Fernández-Rodríguez, Amanda, Resino, Salvador, Miralles, P., López, J.C., Parras, F., Padilla, B., Aldámiz-Echevarría, T, Tejerina, F., Díez, C., Pérez-Latorre, L., Fanciulli, C., Gutiérrez, I., Ramírez, M., Carretero, S., Bellón, J.M., Bermejo, Javier, Arribas, J. R., Montes, M.L., Bernardino, I., Pascual, J.F., Zamora, Francisco, Peña, J.M., Arnalich, F., Díaz, M., Domingo, Pere, Van den Eynde, E., Pérez, M., Ribera, E., Crespo, M., Casado, J.L., Dronda, F., Moreno, A., Pérez-Elías, M.J., Sanfrutos, M.A., Moreno, S., Quereda, C., Arranz, A., Casas, E., de Miguel, J., Schroeder, S., Sanz, J., Santos, I., Bustinduy, M.J., Iribarren, J.A., Rodríguez-Arrondo, F., Von-Wichmann, M.A., Vergas, J., Téllez, M.J., Vinuesa, D., Muñoz, L., Hernández-Quero, J., Ferrer, A., Galindo, M.J., Ortiz, L., Ortega, E., Montero, M., Blanes, M., Cuellar, S., Lacruz, J., Salavert, M., López-Aldeguer, J., Pérez, G., Gaspar, G., Yllescas, M., Crespo, P., Aznar, E., Esteban, H., Instituto de Salud Carlos III, European Regional Development Fund (ERDF/FEDER), Ministerio de Ciencia e Innovación, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Ministerio de Ciencia e Innovación (España), Institut Català de la Salut, [Brochado Ó, Martínez I, Medrano L, Jiménez-Sousa MÁ] Unidad de Infección Viral E Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III (Campus Majadahonda), Madrid, Spain. [Berenguer J] Unidad de Enfermedades Infecciosas/VIH, Hospital General Universitario 'Gregorio Marañón', Madrid, Spain. Instituto de Investigación Sanitaria del Gregorio Marañón, Madrid, Spain. [González-García J] Unidad de VIH, Servicio de Medicina Interna, Hospital Universitario 'La Paz', Madrid, Spain. Instituto de Investigacion Sanitaria La Paz (IdiPAZ), Madrid, Spain. [Navarro J] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Male, 0301 basic medicine, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, lcsh:Medicine, Gene Expression, HIV Infections, Hepacivirus, medicine.disease_cause, 0302 clinical medicine, Interferon, Medicine, Pharmacology (medical), Other subheadings::/therapeutic use [Other subheadings], Interferon therapy, Coinfection, virus diseases, Genetic Phenomena::Gene Expression [PHENOMENA AND PROCESSES], General Medicine, Hepatitis C, Middle Aged, Interferó - Ús terapèutic, Hepatocellular carcinoma, Female, 030211 gastroenterology & hepatology, medicine.drug, Adult, Hepatitis C virus, Peripheral blood mononuclear cell, Virus, HCV clearance, aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intercelular::citocinas::interferones [COMPUESTOS QUÍMICOS Y DROGAS], 03 medical and health sciences, Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interferons [CHEMICALS AND DRUGS], Immune system, Humans, Molecular Biology, Virus Diseases::Coinfection [DISEASES], Otros calificadores::/uso terapéutico [Otros calificadores], business.industry, virosis::coinfección [ENFERMEDADES], Research, lcsh:R, Biochemistry (medical), HIV, Cell Biology, medicine.disease, Expressió gènica, HIV/HCV coinfection, 030104 developmental biology, Virosis, PBMCs, Immunology, Leukocytes, Mononuclear, Gene expression, Interferons, business, fenómenos genéticos::expresión génica [FENÓMENOS Y PROCESOS]
Abstract

Coinfecció pel VIH/VHC; Sistema immunitari; Teràpia amb interferó Coinfección por VIH/VHC; Sistema inmunitario; Terapia con interferón HIV/HCV coinfection; Immune system; Interferon therapy Objective To evaluate the impact of hepatitis C virus (HCV) elimination via interferon (IFN)-based therapy on gene expression profiles related to the immune system in HIV/HCV-coinfected patients. Methods We conducted a prospective study in 28 HIV/HCV-coinfected patients receiving IFN-based therapy at baseline (HIV/HCV-b) and week 24 after sustained virological response (HIV/HCV-f). Twenty-seven HIV-monoinfected patients (HIV-mono) were included as a control. RNA-seq analysis was performed on peripheral blood mononuclear cells (PBMCs). Genes with a fold-change (FC) ≥ 1.5 (in either direction) and false discovery rate (FDR) ≤ 0.05 were identified as significantly differentially expressed (SDE). Results HIV/HCV-b showed six SDE genes compared to HIV-mono group, but no significantly enriched pathways were observed. For HIV/HCV-f vs. HIV/HCV-b, we found 58 SDE genes, 34 upregulated and 24 downregulated in the HIV/HCV-f group. Of these, the most overexpressed were CXCL2, PDCD6IP, ATP5B, IGSF9, RAB26, and CSRNP1, and the most downregulated were IFI44 and IFI44L. These 58 SDE genes revealed two significantly enriched pathways (FDR

Published
2021

240. Guia de Consenso para a Prática Clínica sobre Boas Práticas nos Cuidados em Fim de Vida, das Sociedades Espanhola e Portuguesa de Medicina Interna

Author

Díez-Manglanoa, J., Sánchez Muñoz, L. A., García Fenoll, R., Freire, E., Isasi De Isasmendi Pérez, S., Carneiro, A. H., and Torres Bonafonte, O.

Subjects
Nursing, Steering committee, Good clinical practice, language, Delphi method, Portuguese, Psychology, Palliative sedation, language.human_language
Abstract

Objetivo: Estabelecer recomendações de consenso sobre boas práticas clínicas no acompanhamento de doentes em fim de vida. Métodos: Uma comissão de 12 peritos espanhóis e portugueses propôs 37 recomendações. Realizou-se um processo Delphi em 2 rondas, com a participação dum painel com105 membros, englobando internistas, outros clínicos, enfermeiros, doentes, juristas, especialistas em bioética, gestores de saúde, políticos e jornalistas. Para cada recomendação, foi enviado um questionário com uma escala de Likert com 5 categorias por questão. Definiu-se consenso forte quando > 95% das respostas estavam totalmente de acordo ou > 90% estavam de acordo e totalmente de acordo; consenso fraco quando > 90% estavam totalmente de acordo ou > 80% estavam de acordo e totalmente de acordo. Resultados: O painel abordou sete áreas específicas com 37 recomendações que abarcam: Identificação do doente; Conhecimento dos valores e preferências do doente; Informação; Necessidades do doente; Acompanhamento e cuidados; Sedação paliativa e Cuidados pós-morte. Conclusões: Um Processo Delphi, com participação multidisciplinar, permitiu estabelecer, normas de boas práticas clínicas para os cuidados em fim de vida com envolvimento de doentes, agentes sociais e profissionais de saúde., Medicina Interna, Vol. 28 N.º 1 (2021): Janeiro - Março

Published
2021
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241. Patrones de progresión de la actividad física en pacientes con EPOC

Author

Koreny, M, Demeyer, H, Benet, M, Arbillaga-Etxarri, A, Balcells, E, Barberan-Garcia, A, Gimeno-Santos, E, Hopkinson, NS, De Jong, C, Karlsson, N, Louvaris, Z, Polkey, MI, Puhan, MA, Rabinovich, RA, Rodríguez-Roisin, R, Vall-Casas, P, Vogiatzis, I, Troosters, T, Garcia-Aymerich, J, Urban Training Study Group and PROactive Consortium members, Urban Training Study Group, Delgado, A, Torrent-Pallicer, J, Vilaró, J, Chiaradía, DAR, Marín, A, Ortega, P, Celorrio, N, Teagudo, MM, Montellà, N, Muñoz, L, Toran, P, Simonet, P, Jané, C, Martín-Cantera, C, Borrell, E, PROactive Consortium members, Ivanoff, N, Corriol-Rohou, S, Jarrod, I, Erzen, D, Brindicci, C, Higenbottam, T, Scuri, M, McBride, P, Kamel, N, Tabberer, M, Dobbels, F, De Boer, P, Kulich, K, Glendenning, A, Rudell, K, Wilson, FJ, Nikai, E, Van der Molen, T, MacNee, B, Frei, A, Groningen Research Institute for Asthma and COPD (GRIAC), and EU/IMI Joint Undertaking

Subjects
Male, PROactive Consortium members, Respiratory System, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Medicine and Health Sciences, Pooled data, Determinants, COPD, biology, Patrones de progresión, General Medicine, Lama, Análisis de conglomerados, Respiratory Function Tests, MPOC, Female, EPOC, Determinantes, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Patrons de progressió, Physical activity, 616.2, 03 medical and health sciences, FEV1/FVC ratio, Cluster analysis, Multinomial logistic regression model, Internal medicine, Urban Training Study Group, medicine, Humans, Anàlisi de clústers, In patient, Exercise, Patterns of progression, business.industry, 1103 Clinical Sciences, medicine.disease, biology.organism_classification, C600, Urban Training Study Group and PROactive Consortium members, B900, Dyspnea, 030228 respiratory system, Usual care, Actividad física, Sedentary Behavior, Activitat física, business
Abstract

Introduction: Although mean physical activity in COPD patients declines by 400–500 steps/day annually, it is unknown whether the natural progression is the same for all patients. We aimed to identify distinct physical activity progression patterns using a hypothesis-free approach and to assess their determinants. Methods: We pooled data from two cohorts (usual care arm of Urban Training [NCT01897298] and PROactive initial validation [NCT01388218] studies) measuring physical activity at baseline and 12 months (Dynaport MoveMonitor). We identified clusters (patterns) of physical activity progression (based on levels and changes of steps/day) using k-means, and compared baseline sociodemographic, interpersonal, environmental, clinical and psychological characteristics across patterns. Results: In 291 COPD patients (mean ± SD 68 ± 8 years, 81% male, FEV1 59 ± 19%pred) we identified three distinct physical activity progression patterns: Inactive (n = 173 [59%], baseline: 4621 ± 1757 steps/day, 12-month change (Δ): −487 ± 1201 steps/day), Active Improvers (n = 49 [17%], baseline: 7727 ± 3275 steps/day, Δ: + 3378 ± 2203 steps/day) and Active Decliners (n = 69 [24%], baseline: 11 267 ± 3009 steps/day, Δ: −2217 ± 2085 steps/day). After adjustment in a mixed multinomial logistic regression model using Active Decliners as reference pattern, a lower 6-min walking distance (RRR [95% CI] 0.94 [0.90–0.98] per 10 m, P = .001) and a higher mMRC dyspnea score (1.71 [1.12–2.60] per 1 point, P = .012) were independently related with being Inactive. No baseline variable was independently associated with being an Active Improver. Conclusions: The natural progression in physical activity over time in COPD patients is heterogeneous. While Inactive patients relate to worse scores for clinical COPD characteristics, Active Improvers and Decliners cannot be predicted at baseline. Introducción: Aunque la actividad física en pacientes con EPOC declina una media anual de 400-500 pasos/día, se desconoce si esta progresión es igual en todos los pacientes. Este estudio pretendió identificar los patrones de progresión de la actividad física mediante métodos libres de hipótesis y evaluar sus determinantes. Métodos: Se estudiaron 291 pacientes con EPOC estable (media ± DE: 68 ± 8 años, 81% hombres, VEMS 59 ± 19%pred) de dos cohortes europeas con actividad física basal y a 12 meses (acelerómetro Dynaport MoveMonitor). Se identificaron conglomerados (patrones) de progresión de actividad física basados en los niveles y cambios de pasos/día usando k-means, y se compararon entre patrones las características sociodemográficas, interpersonales, ambientales, clínicas y psicosociales basales. Resultados: Se identificaron tres patrones: inactivo (n = 173 [59%], basal: 4.621 ± 1.757 pasos/día, cambio en 12 meses (Δ): −487 ± 1.201 pasos/día), activo que aumenta (n = 49 [17%], basal: 7.727 ± 3.275 pasos/día, Δ: +3.378 ± 2.203 pasos/día) y activo que reduce (n = 69 [24%], basal: 11.267 ± 3.009 pasos/día, Δ: −2.217 ± 2.085 pasos/día). La distancia en la prueba de la marcha de 6 minutos (6MWD) y la disnea se asociaron independientemente con ser inactivo: RRR [IC 95%] 0,94 [0,90-0,98] por cada 10 m de 6MWD (p = 0,001) y 1,71 [1,12-2,60] por cada punto en la escala mMRC (p = 0,012), respectivamente, en comparación con el patrón activo que reduce. No se encontraron variables basales independientemente asociadas con ser activo que aumenta. Conclusiones: La progresión natural de la actividad física en pacientes con EPOC es heterogénea. Mientras que el patrón de pacientes inactivo se relaciona con peores características clínicas de EPOC, no se pudo predecir la evolución de los activos a aumentar o reducir. info:eu-repo/semantics/acceptedVersion

Published
2021

244. A Comparison between Nuclear Ring Star Formation in LIRGs and in Normal Galaxies with the Very Large Array

Author

Song, Y., primary, Linden, S. T., additional, Evans, A. S., additional, Barcos-Muñoz, L., additional, Privon, G. C., additional, Yoon, I., additional, Murphy, E. J., additional, Larson, K. L., additional, Díaz-Santos, T., additional, Armus, L., additional, Mazzarella, Joseph M., additional, Howell, J., additional, Inami, H., additional, Torres-Albà, N., additional, U, V., additional, Charmandaris, V., additional, McKinney, J., additional, Kunneriath, D., additional, and Momjian, E., additional

Published
2021
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245. A hard X-ray view of luminous and ultra-luminous infrared galaxies in GOALS – I. AGN obscuration along the merger sequence

Author

Ricci, C, primary, Privon, G C, additional, Pfeifle, R W, additional, Armus, L, additional, Iwasawa, K, additional, Torres-Albà, N, additional, Satyapal, S, additional, Bauer, F E, additional, Treister, E, additional, Ho, L C, additional, Aalto, S, additional, Arévalo, P, additional, Barcos-Muñoz, L, additional, Charmandaris, V, additional, Diaz-Santos, T, additional, Evans, A S, additional, Gao, T, additional, Inami, H, additional, Koss, M J, additional, Lansbury, G, additional, Linden, S T, additional, Medling, A, additional, Sanders, D B, additional, Song, Y, additional, Stern, D, additional, U, V, additional, Ueda, Y, additional, and Yamada, S, additional

Published
2021
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249. CON-quest

Author

Falstad, N., primary, Aalto, S., additional, König, S., additional, Onishi, K., additional, Muller, S., additional, Gorski, M., additional, Sato, M., additional, Stanley, F., additional, Combes, F., additional, González-Alfonso, E., additional, Mangum, J. G., additional, Evans, A. S., additional, Barcos-Muñoz, L., additional, Privon, G. C., additional, Linden, S. T., additional, Díaz-Santos, T., additional, Martín, S., additional, Sakamoto, K., additional, Harada, N., additional, Fuller, G. A., additional, Gallagher, J. S., additional, van der Werf, P. P., additional, Viti, S., additional, Greve, T. R., additional, García-Burillo, S., additional, Henkel, C., additional, Imanishi, M., additional, Izumi, T., additional, Nishimura, Y., additional, Ricci, C., additional, and Mühle, S., additional

Published
2021
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250. Patterns of Physical Activity Progression in Patients With COPD [Patrones de progresión de la actividad física en pacientes con EPOC]

Author

Koreny, M. Demeyer, H. Benet, M. Arbillaga-Etxarri, A. Balcells, E. Barberan-Garcia, A. Gimeno-Santos, E. Hopkinson, N.S. De Jong, C. Karlsson, N. Louvaris, Z. Polkey, M.I. Puhan, M.A. Rabinovich, R.A. Rodríguez-Roisin, R. Vall-Casas, P. Vogiatzis, I. Troosters, T. Garcia-Aymerich, J. Delgado, A. Torrent-Pallicer, J. Vilaró, J. Rodriguez-Roisín, R. Chiaradía, D.A.R. Marín, A. Ortega, P. Celorrio, N. Monteagudo, M. Montellà, N. Muñoz, L. Toran, P. Simonet, P. Jané, C. Martín-Cantera, C. Borrell, E. Ivanoff, N. Corriol-Rohou, S. Jarrod, I. Erzen, D. Brindicci, C. Higenbottam, T. Scuri, M. McBride, P. Kamel, N. Tabberer, M. Dobbels, F. de Boer, P. Kulich, K. Glendenning, A. Rudell, K. Wilson, F.J. Hopkinson, N.S. Nikai, E. van der Molen, T. MacNee, B. Frei, A. The Urban Training Study Group PROactive Consortium members The Urban Training Study Group The PROactive Consortium members

Abstract

Introduction: Although mean physical activity in COPD patients declines by 400–500 steps/day annually, it is unknown whether the natural progression is the same for all patients. We aimed to identify distinct physical activity progression patterns using a hypothesis-free approach and to assess their determinants. Methods: We pooled data from two cohorts (usual care arm of Urban Training [NCT01897298] and PROactive initial validation [NCT01388218] studies) measuring physical activity at baseline and 12 months (Dynaport MoveMonitor). We identified clusters (patterns) of physical activity progression (based on levels and changes of steps/day) using k-means, and compared baseline sociodemographic, interpersonal, environmental, clinical and psychological characteristics across patterns. Results: In 291 COPD patients (mean ± SD 68 ± 8 years, 81% male, FEV1 59 ± 19%pred) we identified three distinct physical activity progression patterns: Inactive (n = 173 [59%], baseline: 4621 ± 1757 steps/day, 12-month change (Δ): −487 ± 1201 steps/day), Active Improvers (n = 49 [17%], baseline: 7727 ± 3275 steps/day, Δ: + 3378 ± 2203 steps/day) and Active Decliners (n = 69 [24%], baseline: 11 267 ± 3009 steps/day, Δ: −2217 ± 2085 steps/day). After adjustment in a mixed multinomial logistic regression model using Active Decliners as reference pattern, a lower 6-min walking distance (RRR [95% CI] 0.94 [0.90–0.98] per 10 m, P =.001) and a higher mMRC dyspnea score (1.71 [1.12–2.60] per 1 point, P =.012) were independently related with being Inactive. No baseline variable was independently associated with being an Active Improver. Conclusions: The natural progression in physical activity over time in COPD patients is heterogeneous. While Inactive patients relate to worse scores for clinical COPD characteristics, Active Improvers and Decliners cannot be predicted at baseline. © 2020 SEPAR

Published
2021

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